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Résultats pour
 brevets
1.
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Method for biocatalytic synthesis of Sitagliptin and intermediate thereof
| Numéro d'application |
17054135 |
| Numéro de brevet |
11459549 |
| Statut |
Délivré - en vigueur |
| Date de dépôt |
2018-07-27 |
| Date de la première publication |
2021-04-29 |
| Date d'octroi |
2022-10-04 |
| Propriétaire |
- China Fortune Way Company (Chine)
- Nanjing Redwood Fine Chemical Co., Ltd. (Chine)
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| Inventeur(s) |
- Wu, Fahao
- Yang, Wen
- Li, Gang
- Shi, Hongwei
- Gao, Yangzhe
- Liu, Lili
- Yuan, Zhifa
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Abrégé
Provided is a method for biocatalytic synthesis of Sitagliptin and intermediates thereof, in particular, provided are compounds of Formula (I) and Formula (II), or pharmaceutically acceptable salts thereof, a polypeptide capable of catalyzing conversion of a compound of Formula (I) to a compound of Formula (II), a nucleic acid encoding the polypeptide, a vector and a cell comprising the nucleic acid. In addition, also provided are a method for producing a compound of Formula (II) and Sitagliptin by using the polypeptide and the compound of Formula (I), and a method for preparing the polypeptide.
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2.
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METHOD FOR BIOCATALYTIC SYNTHESIS OF SITAGLIPTIN AND INTERMEDIATE THEREOF
| Numéro d'application |
CN2018097354 |
| Numéro de publication |
2019/214084 |
| Statut |
Délivré - en vigueur |
| Date de dépôt |
2018-07-27 |
| Date de publication |
2019-11-14 |
| Propriétaire |
- CHINA SINOPHARM INTERNATIONAL CORPORATION (Chine)
- NANJING REDWOOD FINE CHEMICAL CO., LTD (Chine)
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| Inventeur(s) |
- Wu, Fahao
- Yang, Wen
- Li, Gang
- Shi, Hongwei
- Gao, Yangzhe
- Liu, Lili
- Yuan, Zhifa
|
Abrégé
Provided is a method for biocatalytic synthesis of Sitagliptin and intermediates thereof, in particular, provided are compounds of Formula (I) and Formula (II), or pharmaceutically acceptable salts thereof, a polypeptide capable of catalyzing conversion of a compound of Formula (I) to a compound of Formula (II), a nucleic acid encoding the polypeptide, a vector and a cell comprising the nucleic acid. In addition, also provided are a method for producing a compound of Formula (II) and Sitagliptin by using the polypeptide and the compound of Formula (I), and a method for preparing the polypeptide.
Classes IPC ?
- C07D 233/56 - Composés hétérocycliques contenant des cycles diazole-1, 3 ou diazole-1, 3 hydrogéné, non condensés avec d'autres cycles comportant deux liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec uniquement des atomes d'hydrogène ou des radicaux ne contenant que des atomes d'hydrogène et de carbone, liés aux atomes de carbone du cycle
- C07D 295/182 - Radicaux dérivés d'acides carboxyliques
- C12N 9/10 - Transférases (2.)
- C12N 15/54 - Transférases (2)
- C12P 13/00 - Préparation de composés organiques contenant de l'azote
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