A composition comprising a solution comprising an active pharmaceutical ingredient comprising an anticholinergic agent, such as ipratropium bromide, and a propellant comprising HFA-152a, HFO-1234ze(E), or both. A metered dose inhaler comprising a metering valve a canister; and an actuator comprising an actuator nozzle; wherein the canister comprises said composition.
A61K 31/40 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil
A61K 31/439 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle le cycle formant une partie d'un système cyclique ponté, p. ex. quinuclidine
A61K 31/5386 - 1,4-Oxazines, p. ex. morpholine condensées en spiro ou formant une partie de systèmes cycliques pontés
A61K 47/06 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite
A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
A metered dose inhaler comprising a metering valve, a canister, an actuator comprising an actuator nozzle, wherein the canister comprises a formulation, the formulation comprising greater than 70% by weight of propellant HFO-1234ze(E), and at least one active pharmaceutical ingredient dissolved in the formulation to form a solution, said active pharmaceutical ingredient preferably selected from beclomethasone, formoterol or tiotropium.
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 31/137 - Arylalkylamines, p. ex. amphétamine, épinéphrine, salbutamol, éphédrine
A61K 31/55 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole
A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone substitués en position 21, p. ex. cortisone, dexaméthasone, prednisone ou aldostérone
A61K 47/06 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite
A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
A61K 47/12 - Acides carboxyliquesLeurs sels ou anhydrides
An inhaler (100) has an actuator (118) configured to interact with a container (110) to selectively release a substance for inhalation. A controller (112) is provided and configured to switch the inhaler between a locked and an unlocked condition. A motion sensor (114) is attached to the inhaler. The controller (112) is configured to store a predetermined motion sequence, and upon detection of the predetermined motion sequence by the motion sensor, the controller is configured to switch the inhaler from the locked condition to the unlocked condition.
A metered dose inhaler comprising: a metering valve; a canister; and an actuator comprising an actuator nozzle; wherein the canister comprises a formulation, the formulation comprising greater than 70% by weight of HFO-1234ze(E); and at least one active pharmaceutical ingredient suspended in the formulation; wherein the metered dose inhaler delivers at least 0.5 milligram (mg) of the at least one active pharmaceutical ingredient per actuation. A metered dose inhaler comprising: a metering valve; a canister; and an actuator comprising an actuator nozzle; wherein the canister comprises a formulation, the formulation comprising greater than 70% by weight of HF A-152a; and at least one active pharmaceutical ingredient suspended in the formulation; wherein the metered dose inhaler delivers at least 0.5 milligram (mg) of the at least one active pharmaceutical ingredient per actuation.
A61K 31/58 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes contenant des hétérocycles, p. ex. danazol, stanozolol, pancuronium ou digitogénine
A61K 31/352 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à six chaînons avec un oxygène comme seul hétéro-atome d'un cycle condensés avec des carbocycles, p. ex. cannabinols, méthanthéline
A61K 31/137 - Arylalkylamines, p. ex. amphétamine, épinéphrine, salbutamol, éphédrine
A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p. ex. rifampine, thiothixène ou sparfloxacine
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
Various embodiments of a metered dose inhaler are disclosed. The inhaler includes a metering valve, a canister, and an actuator having an actuator nozzle. The canister includes a formulation having a propellant including HFA-152a, at least 1% of ethanol by weight, and one or more cannabinoids, wherein the one or more cannabinoids is dissolved in the formulation to form a solution. In one or more embodiments, the cannabinoid includes tetrahydrocannabinol (THC) and/or cannabidiol (CBD).
Various embodiments of a metered dose inhaler are disclosed. The inhaler includes a metering valve, a canister, and an actuator having an actuator nozzle. The canister includes a formulation having a propellant including HFO-1234ze(E), at least 1% of ethanol by weight, and one or more cannabinoids, wherein the one or more cannabinoids is dissolved in the formulation to form a solution. In one or more embodiments, the cannabinoid includes tetrahydrocannabinol (THC) and/or cannabidiol (CBD).
Various embodiments of a metered dose inhaler are disclosed. The inhaler includes a metering valve, a canister, and an actuator having an actuator nozzle. The canister includes a formulation having greater than 70% by weight of HFO-1234ze(E), and at least one active pharmaceutical ingredient suspended in the formulation to form a suspension.
A61K 31/165 - Amides, p. ex. acides hydroxamiques ayant des cycles aromatiques, p. ex. colchicine, aténolol, progabide
A61K 31/57 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone
A61K 31/58 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes contenant des hétérocycles, p. ex. danazol, stanozolol, pancuronium ou digitogénine
Methods of making components for a medicinal delivery device are described, in which a base composition comprising a polysulphone is applied to the surface of a component to create a base layer, a primer composition comprising a silane having two or more reactive silane groups separated by an organic linker group is applied to the base layer to create primed surface, and a coating composition comprising an at least partially fluorinated compound is applied to the primed surface. Corresponding coated components and a medicinal delivery device are disclosed.
B05D 7/00 - Procédés, autres que le flocage, spécialement adaptés pour appliquer des liquides ou d'autres matériaux fluides, à des surfaces particulières, ou pour appliquer des liquides ou d'autres matériaux fluides particuliers
B05D 7/14 - Procédés, autres que le flocage, spécialement adaptés pour appliquer des liquides ou d'autres matériaux fluides, à des surfaces particulières, ou pour appliquer des liquides ou d'autres matériaux fluides particuliers à du métal, p. ex. à des carrosseries de voiture
C08G 65/336 - Polymères modifiés par post-traitement chimique avec des composés organiques contenant du silicium
Various embodiments of a drug delivery device (10, 200, 300) are disclosed. The device includes a backing layer (12, 312) having a first major surface (14, 314) and a second major surface (15) and a plurality of discrete arrays (16, 216, 316) disposed on the first major surface of the backing layer. The plurality of discrete arrays includes a first discrete array (18, 318) that has a first substrate (20, 220, 320) and first microneedles (22, 322) disposed on the first substrate, and a second discrete array (24, 216, 324) that has a second substrate (26, 220, 326) and second microneedles (28, 328) disposed on the second substrate.
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
A61B 5/15 - Dispositifs de prélèvement d'échantillons de sang
Various embodiments of a metered dose inhaler are disclosed. The inhaler includes a container and a metering valve connected to the container. The metering valve includes a valve housing having first and second ends and a metering valve stem that extends through the first end, a metering chamber, and the second end of the valve housing. A first portion of the metering valve stem is disposed through a diaphragm opening of a diaphragm that is disposed at least partially within the first end of the housing and forms a dynamic seal with the diaphragm, and a second portion of the metering valve stem is disposed through a tank seal opening of a tank seal that is disposed at least partially within the second end of the housing and forms a dynamic seal with the tank seal. At least one of the diaphragm or tank seal includes a polytetrafluoroethylene material.
B65D 83/14 - Récipients pour distribuer des contenus liquides ou semi-liquides par pression interne de gaz, c.-à-d. réceptacles aérosols contenant un propulseur
Various embodiments of a microneedle array applicator (12) are disclosed. The applicator includes an applicator body (16) and an opening (22) extending through the body, an actuator (26) configured to slidably engage with the applicator body between an unprimed configuration and an actuated configuration of the applicator, and a plunger (32) disposed at least partially within the opening of the applicator body. The plunger includes a latch (36) configured to engage a slot (40) disposed in an upper portion (18) of the applicator body to retain the plunger at least partially within the opening of the applicator body when the applicator is in the unprimed configuration. The applicator further includes a stored energy device (42). Axially compressing the actuator and the applicator body manipulates the applicator from the unprimed configuration to the actuated configuration, causing the actuator to inwardly deflect the latch and disengage the latch from the slot of the applicator body to release the plunger.
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
13.
METERED DOSE INHALER CANISTER WITH IMPROVED SEALING ARRANGEMENT
A metered dose inhaler valve (26) has a reservoir portion (37) for assembly with a canister (14) for receiving a pressurised formulation of medicament and propellant, a metering valve body (96) defining a metering chamber, and a metering valve stem (24) having an outlet (56) and being axially moveable within the body. The stem moves between a first position in which the chamber is in fluid communication with the canister, and a second position in which the chamber is in fluid communication with the valve stem outlet. A metering valve seal is defined by the valve body and includes an opening through which the stem passes to form a dynamic seal between the stem and at least one of the outside atmosphere and the pressurized canister, where the opening is adapted to be stretched wider by the stem passing through it than it would be absent the valve stem.
Various embodiments of a storage and dispensing apparatus for a pressurised metered dose inhaler and a method of utilizing such apparatus are disclosed. The apparatus includes a canister containing a mixture of a propellant and a therapeutic agent, an electronically actuated valve, and a controller configured to control the valve. The controller is further configured to actuate the valve to agitate the mixture within the canister, and actuate the valve to release a dose of the agitated mixture from the canister, where actuating the valve to agitate and actuating the valve to release a dose are discrete.
Various embodiments of a device for delivery of a medicament and a method of utilizing such device are disclosed. The device can include a canister and an actuator. The actuator includes a housing receiving the canister; a valve block receiving a metering valve of the canister, the valve block defining an expansion chamber for passage of propellant and medicament expelled from the canister; and a nosepiece for insertion into a user's nostril, the nosepiece including a fluid passage and a delivery opening for expulsion of the propellant and medicament into the user's nostril. A flow path is defined through the actuator for passage of propellant and medicament from the canister and includes the expansion chamber, the fluid passage and the delivery opening. Further, the cross-sectional area of the flow path is greater than the lowest cross-sectional area of the metering valve at all points along the flow path.
A device (100) for delivery of a medicament is disclosed. The device includes a canister (102) that includes a container containing a pressurised propellant and the medicament; and a metering valve configured to release a predetermined amount of the pressurised propellant and the medicament. The device (100) further includes an actuator (104) that includes a valve block receiving the metering valve, the valve block defining a chamber for passage of propellant and medicament expelled from the canister; and a delivery tube for insertion into a user's nostril. The delivery tube includes an elongate, flexible fluid conduit in fluid communication with the valve block, the flexible fluid conduit defining at least one delivery opening for delivery of the medicament to the inside of a human or animal nasal cavity in use. The delivery tube includes a positioning element (184) attached to the flexible fluid conduit.
Various embodiments of a metered dose inhaler that includes a metering valve are disclosed. The inhaler includes a reservoir containing a pressurized formulation of medicament and carbon dioxide. The metering valve includes a metering chamber, a metering valve stem, and a metering valve stem seal having an opening through which the metering valve stem passes to form a dynamic seal between the metering valve stem and outside atmosphere. The metering valve stem seal has a Shore D hardness of 45 to 80 and its opening is adapted to be stretched wider by the metering valve stem passing through it than it would be absent the valve stem.
Various embodiments of a drug delivery device and a method of using such device are disclosed. The drug delivery device includes a backing layer having a first major surface and a second major surface, and an array of patch segments defined by segment separation lines disposed in the backing layer. Each segment separation line is adapted to enhance separation of one or more patch segments from the array of patch segments. Further, a patch segment of the array of patch segments includes a polygonal shape.
A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone substitués en position 21, p. ex. cortisone, dexaméthasone, prednisone ou aldostérone
An actuator (100) for an inhaler includes a sleeve (106) having a first end (102) and a second end (104). The sleeve is substantially hollow and defines a longitudinal axis (110) along its length. A base (108) is formed at the first end of the sleeve. A mouthpiece (112) is joined to the sleeve and the base. The mouthpiece is substantially hollow and defines a delivery opening (114). The actuator includes a cover (116) removably attached to the mouthpiece for covering the delivery opening. The actuator further includes a retaining member for retaining the cover to the sleeve upon removal of the cover from the mouthpiece. The retaining member includes a ring (120) disposed around the sleeve. The ring is at least selectively rotatable about the longitudinal axis and slidable along the longitudinal axis relative to the sleeve. The retaining member further includes a strap (122) extending from the ring and attached to the cover.
Various embodiments of an adhesive article and a method of forming such article are disclosed. The adhesive article includes an active pharmaceutical ingredient; a substrate having a first surface and a second surface including a first area and a second area; and a first adhesive layer disposed on the first area of the second surface of the substrate. The active pharmaceutical ingredient is present in the first adhesive layer at a first concentration. The adhesive article also includes a second adhesive layer having a first portion that is in contact with the first adhesive layer and a second portion that is disposed in the second area of the substrate. The active pharmaceutical ingredient is present in the second adhesive layer at a second concentration. The second concentration is less than the first concentration.
An inhaler (100) has an actuator (118) configured to interact with a container (110) to selectively release a substance for inhalation. A controller (112) is provided and configured to switch the inhaler between a locked and an unlocked condition. A motion sensor (114) is attached to the inhaler. The controller (112) is configured to store a predetermined motion sequence, and upon detection of the predetermined motion sequence by the motion sensor, the controller is configured to switch the inhaler from the locked condition to the unlocked condition.
An inhaler (100) has an actuator (118) configured to interact with a container (110) to selectively release a substance for inhalation. A controller (112) is provided and configured to switch the inhaler between a locked and an unlocked condition. A motion sensor (114) is attached to the inhaler. The controller (112) is configured to store a predetermined motion sequence, and upon detection of the predetermined motion sequence by the motion sensor, the controller is configured to switch the inhaler from the locked condition to the unlocked condition.
A composition comprising a solution comprising an active pharmaceutical ingredient comprising an anticholinergic agent, such as ipratropium bromide, and a propellant comprising HFA-152a, HFO-1234ze(E), or both. A metered dose inhaler comprising a metering valve a canister; and an actuator comprising an actuator nozzle; wherein the canister comprises said composition.
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 31/137 - Arylalkylamines, p. ex. amphétamine, épinéphrine, salbutamol, éphédrine
A61K 31/40 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil
A61K 31/439 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle le cycle formant une partie d'un système cyclique ponté, p. ex. quinuclidine
A61K 31/46 - Aza-8-bicyclo[3.2.1]octaneSes dérivés, p. ex. atropine, cocaïne
A61K 31/56 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes
A61K 31/58 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes contenant des hétérocycles, p. ex. danazol, stanozolol, pancuronium ou digitogénine
A61K 47/06 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite
A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
A61K 47/12 - Acides carboxyliquesLeurs sels ou anhydrides
An inhaler comprising a valve having a valve volume of no more than 40 micro liters and a valve having a first layer comprising a silane and a second layer comprising a polyfluoropolyether silane—and albuterol.
A metered dose inhaler comprising a metering valve, a canister, an actuator comprising an actuator nozzle, wherein the canister comprises a formulation, the formulation comprising greater than 70% by weight of propellant HFO-1234ze(E), and at least one active pharmaceutical ingredient dissolved in the formulation to form a solution, said active pharmaceutical ingredient preferably selected from beclomethasone, formoterol or tiotropium.
A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
A61K 47/06 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite
A61K 31/137 - Arylalkylamines, p. ex. amphétamine, épinéphrine, salbutamol, éphédrine
A61K 31/56 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes
A61K 31/58 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes contenant des hétérocycles, p. ex. danazol, stanozolol, pancuronium ou digitogénine
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 31/167 - Amides, p. ex. acides hydroxamiques ayant des cycles aromatiques, p. ex. colchicine, aténolol, progabide ayant l'atome d'azote d'un groupe carboxamide lié directement au cycle aromatique, p. ex. lidocaïne, paracétamol
A61K 31/439 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle le cycle formant une partie d'un système cyclique ponté, p. ex. quinuclidine
A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone substitués en position 21, p. ex. cortisone, dexaméthasone, prednisone ou aldostérone
A61K 47/12 - Acides carboxyliquesLeurs sels ou anhydrides
26.
PROPELLANTS FOR ANTICHOLINERGIC AGENTS IN PRESSURIZED METERED DOSE INHALERS
A composition comprising a solution comprising an active pharmaceutical ingredient comprising an anticholinergic agent, such as ipratropium bromide, and a propellant comprising HFA-152a, HFO-1234ze(E), or both. A metered dose inhaler comprising a metering valve a canister; and an actuator comprising an actuator nozzle; wherein the canister comprises said composition.
A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
A61K 47/06 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite
A61K 31/137 - Arylalkylamines, p. ex. amphétamine, épinéphrine, salbutamol, éphédrine
A61K 31/56 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes
A61K 31/58 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes contenant des hétérocycles, p. ex. danazol, stanozolol, pancuronium ou digitogénine
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 31/40 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil
A61K 31/439 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle le cycle formant une partie d'un système cyclique ponté, p. ex. quinuclidine
A61K 31/46 - Aza-8-bicyclo[3.2.1]octaneSes dérivés, p. ex. atropine, cocaïne
A61K 47/12 - Acides carboxyliquesLeurs sels ou anhydrides
A metered dose inhaler comprising a metering valve, a canister, an actuator comprising an actuator nozzle, wherein the canister comprises a formulation, the formulation comprising greater than 70% by weight of propellant HFO-1234ze(E), and at least one active pharmaceutical ingredient dissolved in the formulation to form a solution, said active pharmaceutical ingredient preferably selected from beclomethasone, formoterol or tiotropium.
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 31/137 - Arylalkylamines, p. ex. amphétamine, épinéphrine, salbutamol, éphédrine
A61K 31/167 - Amides, p. ex. acides hydroxamiques ayant des cycles aromatiques, p. ex. colchicine, aténolol, progabide ayant l'atome d'azote d'un groupe carboxamide lié directement au cycle aromatique, p. ex. lidocaïne, paracétamol
A61K 31/439 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle le cycle formant une partie d'un système cyclique ponté, p. ex. quinuclidine
A61K 31/56 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes
A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone substitués en position 21, p. ex. cortisone, dexaméthasone, prednisone ou aldostérone
A61K 31/58 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes contenant des hétérocycles, p. ex. danazol, stanozolol, pancuronium ou digitogénine
A61K 47/06 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite
A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
A61K 47/12 - Acides carboxyliquesLeurs sels ou anhydrides
A metered dose inhaler comprising a metering valve; a canister; and an actuator comprising an actuator nozzle; wherein the canister comprises a formulation, the formulation comprising greater than 70% by weight of propellant HFO-1234ze(E); ethanol; and at least one active pharmaceutical ingredient suspended in the formulation to form a suspension. A metered dose inhaler comprising a metering valve; a canister; and an actuator comprising an actuator nozzle; wherein the canister comprises a formulation, the formulation comprising a propellant comprising HFO-1234ze(E); ethanol; and an active pharmaceutical ingredient comprising fluticasone, salbutamol or mometasone or pharmaceutically acceptable salts or esters thereof, said ingredients are suspended in the formulation to form a suspension.
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 31/137 - Arylalkylamines, p. ex. amphétamine, épinéphrine, salbutamol, éphédrine
A61K 31/56 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes
A61K 31/58 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes contenant des hétérocycles, p. ex. danazol, stanozolol, pancuronium ou digitogénine
A61K 47/06 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite
A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
A metered dose inhaler comprising a metering valve; a canister; and an actuator comprising an actuator nozzle; wherein the canister comprises a formulation, the formulation comprising greater than 70% by weight of propellant HFO-1234ze(E); ethanol; and at least one active pharmaceutical ingredient suspended in the formulation to form a suspension. A metered dose inhaler comprising a metering valve; a canister; and an actuator comprising an actuator nozzle; wherein the canister comprises a formulation, the formulation comprising a propellant comprising HFO-1234ze(E); ethanol; and an active pharmaceutical ingredient comprising fluticasone, salbutamol or mometasone or pharmaceutically acceptable salts or esters thereof, said ingredients are suspended in the formulation to form a suspension.
A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
A61K 47/06 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite
A61K 31/137 - Arylalkylamines, p. ex. amphétamine, épinéphrine, salbutamol, éphédrine
A61K 31/56 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes
A61K 31/58 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes contenant des hétérocycles, p. ex. danazol, stanozolol, pancuronium ou digitogénine
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A pressurized medicinal composition comprising at least 40%, by weight, of liquid carbon dioxide, a fluid that forms a homogeneous solution with liquid carbon dioxide, and at least one active pharmaceutical ingredient dissolved or suspended in the composition. The composition may have a liquid to supercritical transition temperature greater than 40° C. Also, metered dose inhalers comprising an actuator, and a canister equipped with a metering valve, wherein the canister houses a reservoir comprising a pressurized carrier fluid mixture for dissolving or suspending at least one active pharmaceutical ingredient, the carrier fluid mixture comprising liquid carbon dioxide and a second component that is a liquid at room temperature and pressure.
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 31/137 - Arylalkylamines, p. ex. amphétamine, épinéphrine, salbutamol, éphédrine
A61K 31/56 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes
A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone substitués en position 21, p. ex. cortisone, dexaméthasone, prednisone ou aldostérone
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
Pressurized canisters coated with poly(fluoroalkylene) polymer or a copolymer of poly(fluoralkylenes) and containing a formulation comprising one or more active pharmaceutical ingredients comprising umeclidinium or a salt thereof, vilanterol or a salt thereof, or a combination of two or more of the foregoing, poly(ethylene glycol), and a propellant, inhalers comprising the pressurized canister, as well as methods of using the pressurized canisters and inhalers.
A61K 31/439 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle le cycle formant une partie d'un système cyclique ponté, p. ex. quinuclidine
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 31/137 - Arylalkylamines, p. ex. amphétamine, épinéphrine, salbutamol, éphédrine
Film-forming gel compositions, useful in creating conformable and flexible gel bandages, can be formulate from a film-forming polymer, an amine-rich adhesion promoter, and a volatile solvent. The gel compositions form relatively thick films when dried on tissue, and can exhibit enhanced breathability to promote wound healing. In some cases, the film-forming gel composition can include lidocaine.
A microarray carrier (200) for use with a microarray applicator (100) is provided. The microarray carrier (200) includes a body (202) defining a cavity (210). The microarray carrier (200) also includes a plurality of tabs (220, 222, 224, 226) disposed on the body (202) and extending into the cavity (210). Each of the plurality of tabs (220, 222, 224, 226) defines a contour line along a length thereof extending from a proximal end of the tab adjacent the body to a support surface (228, 230, 232, 234) spaced apart from the body. The support surface (228, 230, 232, 234) is inclined with respect to the contour line where the contour line intersects the support surface (228, 230, 232, 234). A projected area of each of the plurality of tabs (220, 222, 224, 226) onto a horizontal plane (HP) of the cavity (210) is greater than an area of the support surface (228, 230, 232, 234). The support surface (228, 230, 232, 234) is aligned non-perpendicular to the horizontal plane (HP).
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
A61M 35/00 - Dispositifs pour appliquer des agents, p. ex. des remèdes, sur le corps humain
34.
AEROSOL FORMULATION, CANISTER, AND INHALER CONTAINING THE FORMULATION, AND METHOD OF USE
A pressurized canister coated with poly(fluoroalkylene) polymer or a copolymer of poly(fluoralkylenes) and containing a formulation comprising one or more active pharmaceutical ingredients, PVP, and a propellant, as well as methods of using the same.
A61K 31/439 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle le cycle formant une partie d'un système cyclique ponté, p. ex. quinuclidine
A61K 31/137 - Arylalkylamines, p. ex. amphétamine, épinéphrine, salbutamol, éphédrine
A61K 47/32 - Composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. carbomères
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
An inhaler for delivering a medicament to a patient includes an actuator housing for holding the medicament. The actuator housing includes an air inlet for receiving air flow. The actuator housing further defines an air flow path into which the medicament is dispensed. The inhaler also includes a sensor disposed proximal to the air inlet. The sensor is configured to detect an obstruction of the air inlet and to generate an output signal indicative of the obstruction. The inhaler further includes a feedback device configured to receive the output signal from the sensor and to generate a feedback signal. The feedback signal indicates an obstruction of the air inlet.
A system for use with an inhaler includes an actuator housing. The system includes a loudspeaker disposed within the actuator housing. The loudspeaker is configured to emit an acoustic pulse during use of the inhaler by a patient. The system also includes a microphone disposed within the actuator housing. The microphone is configured to receive reflected sound generated in response to the acoustic pulse. The system further includes a controller communicably coupled to the microphone. The controller is configured to determine a parameter of the oral cavity of the patient based on the reflected sound.
A warning system for use with an inhaler includes an operating mechanism that is configured to be actuated to a reset state, a primed state, and a fired state. The inhaler dispenses a metered dose of a medicament upon actuation of the operating mechanism from the primed state to the fired state. The warning system includes a control circuit that is activated upon actuation of the operating mechanism from the primed state to the fired state. The warning system also includes an alert device communicably coupled to the control circuit and configured to generate a warning. Further, the control circuit is configured to control the alert device to generate the warning until the operating mechanism has been actuated from the fired state to the reset state.
Various embodiments of a storage and dispensing apparatus for a pressurised metered dose inhaler and a method of utilizing such apparatus are disclosed. The apparatus includes a canister containing a mixture of a propellant and a therapeutic agent, an electronically actuated valve, and a controller configured to control the valve. The controller is further configured to actuate the valve to agitate the mixture within the canister, and actuate the valve to release a dose of the agitated mixture from the canister, where actuating the valve to agitate and actuating the valve to release a dose are discrete.
Various embodiments of a storage and dispensing apparatus for a pressurised metered dose inhaler and a method of utilizing such apparatus are disclosed. The apparatus includes a canister containing a mixture of a propellant and a therapeutic agent, an electronically actuated valve, and a controller configured to control the valve. The controller is further configured to actuate the valve to agitate the mixture within the canister, and actuate the valve to release a dose of the agitated mixture from the canister, where actuating the valve to agitate and actuating the valve to release a dose are discrete.
B65D 77/00 - Paquets réalisés en enfermant des objets ou des matériaux dans des réceptacles préformés, p. ex. des boîtes, des cartons, des sacs ou des sachets
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
B65D 75/00 - Paquets comportant des objets ou matériaux partiellement ou complètement enfermés dans des bandelettes, des feuilles, des flans, des tubes ou des bandes en matériau souple mince, p. ex. dans des enveloppes pliées
B65D 81/26 - Adaptations pour empêcher la détérioration ou l'altération du contenuApplications au réceptacle ou au matériau d'emballage d'agents de conservation des aliments, de fongicides, d'insecticides ou de produits repoussant les animaux avec dispositifs pour évacuer ou absorber les fluides, p. ex. s'écoulant du contenuEmploi de produits empêchant la corrosion ou de dessiccateurs
41.
DEVICE FOR DELIVERY OF A COMPOUND TO SPECIFIC REGIONS OF THE NASAL CAVITY
Various embodiments of a device for delivery of a medicament and a method of utilizing such device are disclosed. The device can include a canister and an actuator. The actuator includes a housing receiving the canister; a valve block receiving a metering valve of the canister, the valve block defining an expansion chamber for passage of propellant and medicament expelled from the canister; and a nosepiece for insertion into a user's nostril, the nosepiece including a fluid passage and a delivery opening for expulsion of the propellant and medicament into the user's nostril. A flow path is defined through the actuator for passage of propellant and medicament from the canister and includes the expansion chamber, the fluid passage and the delivery opening. Further, the cross-sectional area of the flow path is greater than the lowest cross-sectional area of the metering valve at all points along the flow path.
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61M 11/02 - Pulvérisateurs ou vaporisateurs spécialement destinés à des usages médicaux agissant par pression d'air sur les liquides à pulvériser ou vaporiser
A61M 15/08 - Dispositifs d'inhalation placés dans le nez
B05B 1/04 - Buses, têtes de pulvérisation ou autres dispositifs de sortie, avec ou sans dispositifs auxiliaires tels que valves, moyens de chauffage agencés pour produire un jet, un pulvérisat ou tout autre écoulement de forme ou de nature particulière, p. ex. sous forme de gouttes individuelles de forme plane, p. ex. en forme d'éventail, en forme de lame
B05B 1/32 - Buses, têtes de pulvérisation ou autres dispositifs de sortie, avec ou sans dispositifs auxiliaires tels que valves, moyens de chauffage agencés pour commander un débit, p. ex. à l'aide de conduits de section réglable dans lesquels un élément de valve fait partie de l'orifice de sortie
42.
DEVICE FOR DELIVERY OF A COMPOUND TO SPECIFIC REGIONS OF THE NASAL CAVITY
Various embodiments of a device for delivery of a medicament and a method of utilizing such device are disclosed. The device can include a canister and an actuator. The actuator includes a housing receiving the canister; a valve block receiving a metering valve of the canister, the valve block defining an expansion chamber for passage of propellant and medicament expelled from the canister; and a nosepiece for insertion into a user's nostril, the nosepiece including a fluid passage and a delivery opening for expulsion of the propellant and medicament into the user's nostril. A flow path is defined through the actuator for passage of propellant and medicament from the canister and includes the expansion chamber, the fluid passage and the delivery opening. Further, the cross-sectional area of the flow path is greater than the lowest cross-sectional area of the metering valve at all points along the flow path.
A61M 15/08 - Dispositifs d'inhalation placés dans le nez
A61M 11/02 - Pulvérisateurs ou vaporisateurs spécialement destinés à des usages médicaux agissant par pression d'air sur les liquides à pulvériser ou vaporiser
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
B05B 1/04 - Buses, têtes de pulvérisation ou autres dispositifs de sortie, avec ou sans dispositifs auxiliaires tels que valves, moyens de chauffage agencés pour produire un jet, un pulvérisat ou tout autre écoulement de forme ou de nature particulière, p. ex. sous forme de gouttes individuelles de forme plane, p. ex. en forme d'éventail, en forme de lame
B05B 1/32 - Buses, têtes de pulvérisation ou autres dispositifs de sortie, avec ou sans dispositifs auxiliaires tels que valves, moyens de chauffage agencés pour commander un débit, p. ex. à l'aide de conduits de section réglable dans lesquels un élément de valve fait partie de l'orifice de sortie
Various embodiments of a drug delivery device and a method of using such device are disclosed. The drug delivery device includes a backing layer having a first major surface and a second major surface, and an array of patch segments defined by segment separation lines disposed in the backing layer. Each segment separation line is adapted to enhance separation of one or more patch segments from the array of patch segments. Further, a patch segment of the array of patch segments includes a polygonal shape.
A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone substitués en position 21, p. ex. cortisone, dexaméthasone, prednisone ou aldostérone
Various embodiments of a drug delivery device and a method of using such device are disclosed. The drug delivery device includes a backing layer having a first major surface and a second major surface, and an array of patch segments defined by segment separation lines disposed in the backing layer. Each segment separation line is adapted to enhance separation of one or more patch segments from the array of patch segments. Further, a patch segment of the array of patch segments includes a polygonal shape.
A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone substitués en position 21, p. ex. cortisone, dexaméthasone, prednisone ou aldostérone
45.
DRUG DELIVERY DEVICE FOR DELIVERY OF CLOBETASOL PROPIONATE
A drug delivery device generally includes a substrate that includes a film cured under an atmospheric-pressure nitrogen dielectric barrier discharge, a reservoir disposed on at least a portion of the substrate, and a release liner disposed on at least a portion of the reservoir. The reservoir generally includes an adhesive composition and clobetasol propionate.
A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone substitués en position 21, p. ex. cortisone, dexaméthasone, prednisone ou aldostérone
46.
UMECLIDINIUM AND VILANTEROL FORMULATION AND INHALER
A composition comprising particulate umeclidinium or a pharmaceutically acceptable salt or solvate thereof, particulate vilanterol or a pharmaceutically acceptable salt or solvate thereof, and 1,1-difluoroethane.
A61K 31/439 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle le cycle formant une partie d'un système cyclique ponté, p. ex. quinuclidine
A61K 47/06 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite
A61K 31/137 - Arylalkylamines, p. ex. amphétamine, épinéphrine, salbutamol, éphédrine
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
An inhaler having an air inlet, a medicament source, and an outlet for delivering an air and medicament admixture to a user, the inhaler including a primary power supply for powering the controller and a sensor for detecting a recent shake event, wherein, the sensor is independent of the primary power source and, in use, the sensor provides the controller with a signal indicative of any recent shake event upon the powering up of the controller prior to use of the inhaler.
Provided herein are methods for treating osteoporosis and increasing bone mass density, that includes administering once a day, for about 5 minutes, a transdermal patch loaded with about 300 μg of abaloparatide, and ZnCl2 at a molar ratio of 2.2:1 of ZnCl2:abaloparatide. Also provided are the single-use transdermal patches loaded with about 300 μg of abaloparatide, and ZnCl2 at a molar ratio of 2.2:1 of ZnCl2:abaloparatide.
Transdermal patch having at least one pharmaceutically active ingredient and a tamper-evidencing element, as well as methods of making and using the same.
A61M 35/00 - Dispositifs pour appliquer des agents, p. ex. des remèdes, sur le corps humain
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
An actuator (100) for an inhaler includes a sleeve (106) having a first end (102) and a second end (104). The sleeve is substantially hollow and defines a longitudinal axis (110) along its length. A base (108) is formed at the first end of the sleeve. A mouthpiece (112) is joined to the sleeve and the base. The mouthpiece is substantially hollow and defines a delivery opening (114). The actuator includes a cover (116) removably attached to the mouthpiece for covering the delivery opening. The actuator further includes a retaining member for retaining the cover to the sleeve upon removal of the cover from the mouthpiece. The retaining member includes a ring (120) disposed around the sleeve. The ring is at least selectively rotatable about the longitudinal axis and slidable along the longitudinal axis relative to the sleeve. The retaining member further includes a strap (122) extending from the ring and attached to the cover.
B65D 41/00 - Capuchons, p. ex. couvercles à rebords ou capsules à sertissage, c.-à-d. éléments ayant des parties prenant sur la périphérie extérieure d'un col ou d'une paroi limitant une ouverture de versement ou de déchargeCouvercles de protection en forme de capuchons pour les éléments de fermeture, p. ex. couvercles décoratifs en feuille de métal ou en papier
B65D 55/16 - Dispositifs empêchant la perte des éléments de fermeture amovibles
B65D 47/14 - Fermetures avec dispositifs de décharge autres que des pompes avec goulottes ou tubes de déversementFermetures avec dispositifs de décharge autres que des pompes avec tuyères ou passages pour la décharge ayant des fermetures amovibles et des moyens de retenir la fermeture
Various embodiments of an adhesive article and a method of forming such article are disclosed. The adhesive article includes an active pharmaceutical ingredient; a substrate having a first surface and a second surface including a first area and a second area; and a first adhesive layer disposed on the first area of the second surface of the substrate. The active pharmaceutical ingredient is present in the first adhesive layer at a first concentration. The adhesive article also includes a second adhesive layer having a first portion that is in contact with the first adhesive layer and a second portion that is disposed in the second area of the substrate. The active pharmaceutical ingredient is present in the second adhesive layer at a second concentration. The second concentration is less than the first concentration.
A composition comprising particulate fluticasone or a pharmaceutically acceptable salt or solvate thereof, particulate vilanterol or a pharmaceutically acceptable salt or solvate thereof, and 1,1-difluoroethane.
An inhaler comprising a valve having a valve volume of no more than 40 micro liters and a valve having a first layer comprising a silane and a second layer comprising a polyfluoropolyether silane - and albuterol.
B05D 5/08 - Procédés pour appliquer des liquides ou d'autres matériaux fluides aux surfaces pour obtenir des effets, finis ou des structures de surface particuliers pour obtenir une surface antifriction ou anti-adhésive
B05D 7/00 - Procédés, autres que le flocage, spécialement adaptés pour appliquer des liquides ou d'autres matériaux fluides, à des surfaces particulières, ou pour appliquer des liquides ou d'autres matériaux fluides particuliers
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 31/137 - Arylalkylamines, p. ex. amphétamine, épinéphrine, salbutamol, éphédrine
05 - Produits pharmaceutiques, vétérinaires et hygièniques
06 - Métaux communs et minerais; objets en métal
10 - Appareils et instruments médicaux
Produits et services
Drug delivery agents in the form of transdermal patches, creams, gels, lotions, ointments, capsules, liquids, tablets, and oral transmucosals that facilitate the delivery of pharmaceutical and biological preparations; transdermal drug delivery patches for use in pain management; transdermal drug delivery patches for use in the treatment of osteoporosis, cardiac disorders, coronary artery disease, diabetes, menopausal symptoms, and central nervous system disorders; drug delivery devices, sold filled, for the subcutaneous and intradermal administration of pharmaceutical and biological preparations for the treatment of a wide variety of conditions and that are developed by or in collaboration with the distributors of the filled devices; inhalers sold filled with aerosol inhalation products for the treatment of a wide variety of conditions and that are developed by or in collaboration with the distributors of the filled devices; pharmaceutical and biological preparations for inhalation for use in treatment of respiratory diseases and disorders; pharmaceutical and biological preparations for inhalation for use in treatment of cancer; pharmaceutical and biological preparations for use in the treatment of diabetes, osteoporosis, autoimmune disorders, and cancer; pharmaceutical and biological preparations for use with vaccinations; drug delivery systems composed of microneedles in the nature of needle-shaped microstructures sold with pharmaceutical and biological preparations filling or coating the microneedles intended for the treatment of a wide variety of conditions and that are developed by or in collaboration with the distributors of the filled devices Metal canisters, sold empty, for use in conjunction with inhalers Inhalers for therapeutic and medical uses; chambers for inhalers; spacers for inhalers; medical apparatus for facilitating the inhalation of pharmaceutical preparations, namely, dose counters, dose indicators for medical purposes, and metal canisters being a component of inhalers; instruments and apparatus provided empty for the inhalation of pharmaceutical and biological preparations; drug delivery systems composed of microneedles in the nature of needle-shaped microstructures, sold empty, for use in delivery of pharmaceutical and biological preparations
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Custom manufacture of pharmaceutical preparations, biological preparations, drug delivery systems, and drug delivery agents for others Research and development in the fields of biologics, pharmaceuticals, and medicine; research and development of new products for others; research and development of pharmaceutical preparations; research and development of biological preparations; research and development of drug delivery systems and devices; design for others in the field of pharmaceutical preparations; design for others in the field of biological preparations; design for others in the field of drug delivery systems and devices; testing of pharmaceutical preparations; testing of biological preparations; testing of drug delivery systems and devices
A metered dose inhaler equipped with a metering valve and having an aerosol canister containing a pharmaceutical composition comprising propellant, ethanol, citric acid, and tiotropium or a pharmaceutically acceptable salt or solvate thereof dissolved in the composition, wherein the aerosol canister has an internal surface that is a non-metal material that is in contact with the pharmaceutical composition.
A61K 31/5386 - 1,4-Oxazines, p. ex. morpholine condensées en spiro ou formant une partie de systèmes cycliques pontés
A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
A61K 47/12 - Acides carboxyliquesLeurs sels ou anhydrides
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 47/24 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant des atomes autres que des atomes de carbone, d'hydrogène, d'oxygène, d'halogènes, d'azote ou de soufre, p. ex. cyclométhicone ou phospholipides
57.
MEDICINAL COMPOSITIONS FOR CARBON DIOXIDE BASED METERED DOSE INHALERS
A pressurized medicinal composition comprising at least 40%, by weight, of liquid carbon dioxide, a fluid that forms a homogeneous solution with liquid carbon dioxide, and at least one active pharmaceutical ingredient dissolved or suspended in the composition. The composition may have a liquid to supercritical transition temperature greater than 40ºC. Also, metered dose inhalers comprising an actuator, and a canister equipped with a metering valve, wherein the canister houses a reservoir comprising a pressurized carrier fluid mixture for dissolving or suspending at least one active pharmaceutical ingredient, the carrier fluid mixture comprising liquid carbon dioxide and a second component that is a liquid at room temperature and pressure.
A61K 9/72 - Préparations médicinales caractérisées par un aspect particulier à fumer ou inhaler
A61K 31/137 - Arylalkylamines, p. ex. amphétamine, épinéphrine, salbutamol, éphédrine
A61K 31/167 - Amides, p. ex. acides hydroxamiques ayant des cycles aromatiques, p. ex. colchicine, aténolol, progabide ayant l'atome d'azote d'un groupe carboxamide lié directement au cycle aromatique, p. ex. lidocaïne, paracétamol
A61K 31/194 - Acides carboxyliques, p. ex. acide valproïque ayant plusieurs groupes carboxyle, p. ex. acides succinique, maléique ou phtalique
A61K 31/40 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil
A61K 31/56 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes
A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone substitués en position 21, p. ex. cortisone, dexaméthasone, prednisone ou aldostérone
A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
58.
MEDICINAL COMPOSITIONS FOR CARBON DIOXIDE BASED METERED DOSE INHALERS
A pressurized medicinal composition comprising at least 40%, by weight, of liquid carbon dioxide, a fluid that forms a homogeneous solution with liquid carbon dioxide, and at least one active pharmaceutical ingredient dissolved or suspended in the composition. The composition may have a liquid to supercritical transition temperature greater than 40ºC. Also, metered dose inhalers comprising an actuator, and a canister equipped with a metering valve, wherein the canister houses a reservoir comprising a pressurized carrier fluid mixture for dissolving or suspending at least one active pharmaceutical ingredient, the carrier fluid mixture comprising liquid carbon dioxide and a second component that is a liquid at room temperature and pressure.
A61K 31/137 - Arylalkylamines, p. ex. amphétamine, épinéphrine, salbutamol, éphédrine
A61K 31/167 - Amides, p. ex. acides hydroxamiques ayant des cycles aromatiques, p. ex. colchicine, aténolol, progabide ayant l'atome d'azote d'un groupe carboxamide lié directement au cycle aromatique, p. ex. lidocaïne, paracétamol
A61K 31/40 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil
A61K 31/56 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes
A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone substitués en position 21, p. ex. cortisone, dexaméthasone, prednisone ou aldostérone
A process of making a microneedle array comprising providing a microneedle array having a plurality of microneedles of a desired shape, illuminating at least a portion of said microneedle array that comprises at least one microneedle, capturing an observed image of said at least one microneedle using an optical device, electronically processing said observed image and determining at least one shape parameter for said at least one microneedle, accepting said microneedle array if said at least one shape parameter is within an acceptable range, thereby providing a microneedle array that comprises a known shape of the plurality of microneedles.
G06T 7/50 - Récupération de la profondeur ou de la forme
G01N 21/84 - Systèmes spécialement adaptés à des applications particulières
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
G01B 11/06 - Dispositions pour la mesure caractérisées par l'utilisation de techniques optiques pour mesurer la longueur, la largeur ou l'épaisseur pour mesurer l'épaisseur
G01N 21/95 - Recherche de la présence de criques, de défauts ou de souillures caractérisée par le matériau ou la forme de l'objet à analyser
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Drug delivery agents in the form of transdermal patches,
creams, gels, lotions, ointments, capsules, liquids,
tablets, and oral transmucosals that facilitate the delivery
of pharmaceutical and biological preparations; transdermal
drug delivery patches for use in pain management;
transdermal drug delivery patches for use in the treatment
of osteoporosis, cardiac disorders, coronary artery disease,
diabetes, menopausal symptoms, and central nervous system
disorders; drug delivery devices, sold filled, for the
subcutaneous and intradermal administration of
pharmaceutical and biological preparations developed by or
in collaboration with the distributors of the filled
devices; inhalers sold filled with aerosol inhalation
products, developed by or in collaboration with the
distributors of the filled devices; pharmaceutical and
biological preparations for inhalation for use in treatment
of respiratory diseases and disorders; pharmaceutical and
biological preparations for inhalation for use in treatment
of cancer; pharmaceutical and biological preparations for
use in the treatment of diabetes, osteoporosis, autoimmune
disorders, and cancer; pharmaceutical and biological
preparations for use with vaccinations; drug delivery
systems composed of microneedles in the nature of
needle-shaped microstructures sold filled with
pharmaceutical and biological preparations developed by or
in collaboration with the distributors of the filled
devices. Inhalers for therapeutic and medical uses; chambers for
inhalers; spacers for inhalers; apparatus for facilitating
the inhalation of pharmaceutical preparations, namely dose
counters, dose indicators, and metal canisters for use in
inhalers; instruments and apparatus provided empty for the
inhalation of pharmaceutical and biological preparations;
drug delivery systems composed of microneedles in the nature
of needle-shaped microstructures for use in delivery of
pharmaceutical and biological preparations. Custom manufacture of pharmaceutical preparations,
biological preparations, drug delivery systems, and drug
delivery agents for others. Research and development in the fields of biologics,
pharmaceuticals, and medicine; research and development of
new products for others; research and development of
pharmaceutical preparations; research and development of
biological preparations; research and development of drug
delivery systems and devices; design for others in the field
of pharmaceutical preparations; design for others in the
field of biological preparations; design for others in the
field of drug delivery systems and devices; testing of
pharmaceutical preparations; testing of biological
preparations; testing of drug delivery systems and devices.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical preparations for human use; pharmaceutical preparations for treating respiratory diseases. Medical and surgical apparatus and instruments; inhalers; parts and fittings for all the aforesaid goods.
Microarray applicator (10000), a method of using the same and a kit. The microarray applicator comprising a housing (2000), a microarray holder (8100) and a plunger (7000). The plunger comprising a first ridge (7310) and a second ridge (7320), both engagable to a notch (2320). Microarray applicator does not uses springs or pre-biased mechanisms to reduce costs.
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
Various embodiments of a metered dose inhaler that includes a metering valve are disclosed. The inhaler includes a reservoir containing a pressurized formulation of medicament and carbon dioxide. The metering valve includes a metering chamber, a metering valve stem, and a metering valve stem seal having an opening through which the metering valve stem passes to form a dynamic seal between the metering valve stem and outside atmosphere. The metering valve stem seal has a Shore D hardness of 45 to 80 and its opening is adapted to be stretched wider by the metering valve stem passing through it than it would be absent the valve stem.
Various embodiments of a metered dose inhaler that includes a metering valve are disclosed. The inhaler includes a reservoir containing a pressurized formulation of medicament and carbon dioxide. The metering valve includes a metering chamber, a metering valve stem, and a metering valve stem seal having an opening through which the metering valve stem passes to form a dynamic seal between the metering valve stem and outside atmosphere. The metering valve stem seal has a Shore D hardness of 45 to 80 and its opening is adapted to be stretched wider by the metering valve stem passing through it than it would be absent the valve stem.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical preparations for human use; pharmaceutical preparations for treating respiratory diseases. Medical and surgical apparatus and instruments; inhalers; parts and fittings for all the aforesaid goods.
66.
Method for making medicinal delivery device having multi-layer coating
Methods of making components for a medicinal delivery device are described, in which a base composition comprising a polysulphone is applied to the surface of a component to create a base layer, a primer composition comprising a silane having two or more reactive silane groups separated by an organic linker group is applied to the base layer to create primed surface, and a coating composition comprising an at least partially fluorinated compound is applied to the primed surface. Corresponding coated components and a medicinal delivery device are disclosed.
B05D 7/14 - Procédés, autres que le flocage, spécialement adaptés pour appliquer des liquides ou d'autres matériaux fluides, à des surfaces particulières, ou pour appliquer des liquides ou d'autres matériaux fluides particuliers à du métal, p. ex. à des carrosseries de voiture
B05D 7/00 - Procédés, autres que le flocage, spécialement adaptés pour appliquer des liquides ou d'autres matériaux fluides, à des surfaces particulières, ou pour appliquer des liquides ou d'autres matériaux fluides particuliers
C08G 65/336 - Polymères modifiés par post-traitement chimique avec des composés organiques contenant du silicium
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Drug delivery agents in the form of transdermal patches,
creams, gels, lotions, ointments, capsules, liquids,
tablets, and oral transmucosals that facilitate the delivery
of pharmaceutical and biological preparations; transdermal
drug delivery patches for use in pain management;
transdermal drug delivery patches for use in the treatment
of osteoporosis, cardiac disorders, coronary artery disease,
diabetes, menopausal symptoms, and central nervous system
disorders; pharmaceutical and biological preparations for
inhalation for use in treatment of respiratory diseases and
disorders; pharmaceutical and biological preparations for
inhalation for use in treatment of cancer; pharmaceutical
and biological preparations for use in the treatment of
diabetes, osteoporosis, autoimmune disorders, and cancer;
pharmaceutical and biological preparations for use with
vaccinations; microneedle drug delivery systems (term
considered too vague by the International Bureau - Rule 13
(2) (b) of the Regulations); microsystems for delivery of
pharmaceutical and biological preparations (term considered
too vague by the International Bureau - Rule 13 (2) (b) of
the Regulations). Inhalers for therapeutic and medical uses; chambers for
inhalers; spacers for inhalers; apparatus for facilitating
the inhalation of pharmaceutical preparations, namely dose
counters, dose indicators, and metal canisters for use in
inhalers; instruments and apparatus provided empty for the
inhalation of pharmaceutical and biological preparation;
inhalers filled with aerosol inhalation products;
subcutaneous and intradermal drug delivery devices sold
filled with pharmaceutical and biological preparations. Custom manufacture of pharmaceutical preparations,
biological preparations, drug delivery systems, and drug
delivery agents for others. Research and development in the fields of biologics,
pharmaceuticals, and medicine; research and development of
new products for others; research and development of
pharmaceutical preparations; research and development of
biological preparations; research and development of drug
delivery systems and devices; design for others in the field
of pharmaceutical preparations; design for others in the
field of biological preparations; design for others in the
field of drug delivery systems and devices; testing of
pharmaceutical preparations; testing of biological
preparations; testing of drug delivery systems and devices.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Drug delivery agents in the form of transdermal patches,
creams, gels, lotions, ointments, capsules, liquids,
tablets, and oral transmucosals that facilitate the delivery
of pharmaceutical and biological preparations; transdermal
drug delivery patches for use in pain management;
transdermal drug delivery patches for use in the treatment
of osteoporosis, cardiac disorders, coronary artery disease,
diabetes, menopausal symptoms, and central nervous system
disorders; drug delivery devices, sold filled, for the
subcutaneous and intradermal administration of
pharmaceutical and biological preparations developed by or
in collaboration with the distributors of the filled
devices; inhalers sold filled with aerosol inhalation
products, developed by or in collaboration with the
distributors of the filled devices; pharmaceutical and
biological preparations for inhalation for use in treatment
of respiratory diseases and disorders; pharmaceutical and
biological preparations for inhalation for use in treatment
of cancer; pharmaceutical and biological preparations for
use in the treatment of diabetes, osteoporosis, autoimmune
disorders, and cancer; pharmaceutical and biological
preparations for use with vaccinations; drug delivery
systems composed of microneedles in the nature of
needle-shaped microstructures sold filled with
pharmaceutical and biological preparations developed by or
in collaboration with the distributors of the filled
devices. Inhalers for therapeutic and medical uses; chambers for
inhalers; spacers for inhalers; apparatus for facilitating
the inhalation of pharmaceutical preparations, namely dose
counters, dose indicators, and metal canisters for use in
inhalers; instruments and apparatus provided empty for the
inhalation of pharmaceutical and biological preparations;
drug delivery systems composed of microneedles in the nature
of needle-shaped microstructures for use in delivery of
pharmaceutical and biological preparations. Custom manufacture of pharmaceutical preparations,
biological preparations, drug delivery systems, and drug
delivery agents for others. Research and development in the fields of biologics,
pharmaceuticals, and medicine; research and development of
new products for others; research and development of
pharmaceutical preparations; research and development of
biological preparations; research and development of drug
delivery systems and devices; design for others in the field
of pharmaceutical preparations; design for others in the
field of biological preparations; design for others in the
field of drug delivery systems and devices; testing of
pharmaceutical preparations; testing of biological
preparations; testing of drug delivery systems and devices.
69.
APPLICATION FOR APPLYING A MICRONEEDLE DEVICE TO SKIN
An applicator and method for applying a microneedle device to skin. The applicator can include a housing and a reciprocating support structure slidably engaged with the housing. The reciprocating support structure can have a plurality of alignment feet. The applicator can have a lockout mechanism that prevents actuation if the alignment feet are not evenly aligned. The applicator can include a device life indicator that is capable of counting the number of use cycles that the applicator has undergone and providing feedback to the user. The applicator can include a dose timer capable of determining the time that has elapsed after actuation of the device and providing feedback to the user.
A61M 5/50 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras avec des moyens pour empêcher la réutilisation ou pour indiquer si le dispositif est défectueux, usagé, non stérile ou si l'on a tenté de l'utiliser
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
70.
AEROSOL FORMULATION, CANISTER AND INHALER CONTAINING THE FORMULATION, AND METHOD OF USE
A pressurized canister coated with poly(fluoroalkylene) polymer or a copolymer of poly(fluoralkylenes) and containing a formulation comprising one or more active pharmaceutical ingredients, PVP, and a propellant, as well as methods of using the same.
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 47/32 - Composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. carbomères
71.
AEROSOL FORMULATION, CANISTER AND INHALER CONTAINING THE FORMULATION, AND METHOD OF USE
Pressurized canisters coated with poly(fluoroalkylene) polymer or a copolymer of poly(fluoralkylenes) and containing a formulation comprising one or more active pharmaceutical ingredients comprising umeclidinium or a salt thereof, vilanterol or a salt thereof, or a combination of two or more of the foregoing, poly(ethylene glycol), and a propellant, inhalers comprising the pressurized canister, as well as methods of using the pressurized canisters and inhalers.
A61K 31/138 - Aryloxyalkylamines, p. ex. propranolol, tamoxifène, phénoxybenzamine
A61K 31/439 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle le cycle formant une partie d'un système cyclique ponté, p. ex. quinuclidine
Microarray applicator (10000) including a microarray carrier (8000), which is retained within a housing (2000) by virtue of microarray carrier (8100) being engaged withholder (2400). Microarray patch (8200) and flexible backing (8220) are positioned such that the central portion (8210) has microneedles (8211) protrude in the direction opposite from the bottom (7200) of plunger (7000). Plunger (7000) is in a first position, having first notch (7310) engaged with ridge (2320). After activation, wherein plunger (7000) is in a second position such that second notch (7320) is engaged with ridge (2320). Here, bottom (7200) of plunger (7000) extends below first major surface (2100) of housing (2000) and has ejected microarray patch (8200).
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
A microarray carrier (200) for use with a microarray applicator (100) is provided. The microarray carrier (200) includes a body (202) defining a cavity (210). The microarray carrier (200) also includes a plurality of tabs (220, 222, 224, 226) disposed on the body (202) and extending into the cavity (210). Each of the plurality of tabs (220, 222, 224, 226) defines a contour line along a length thereof extending from a proximal end of the tab adjacent the body to a support surface (228, 230, 232, 234) spaced apart from the body. The support surface (228, 230, 232, 234) is inclined with respect to the contour line where the contour line intersects the support surface (228, 230, 232, 234). A projected area of each of the plurality of tabs (220, 222, 224, 226) onto a horizontal plane (HP) of the cavity (210) is greater than an area of the support surface (228, 230, 232, 234). The support surface (228, 230, 232, 234) is aligned non-perpendicular to the horizontal plane (HP).
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
A drive mechanism for a medicinal inhaler, the inhaler comprising: a patient port; a canister actuable by the drive mechanism to deliver a dose of medicament to the patient port, the drive mechanism comprising: a follower which moves between a first position in which the mechanism is primed for use and a second position in which the follower engages the canister to deliver a dose of medicament to the patient port, the follower being carried on a rocker plate which pivots as the follower moves between its first and second position, wherein the rocker plate engages a switch when the follower is in its second position to indicate that a dose of medicament has been delivered to the patient port.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
(1) Drug delivery agents in the form of transdermal patches, creams, gels, lotions, ointments, capsules, liquids, tablets, and oral transmucosals that facilitate the delivery of pharmaceutical and biological preparations; transdermal drug delivery patches for use in pain management; transdermal drug delivery patches for use in the treatment of osteoporosis, cardiac disorders, coronary artery disease, diabetes, menopausal symptoms, and central nervous system disorders; drug delivery devices, sold filled, for the subcutaneous and intradermal administration of pharmaceutical and biological preparations developed by or in collaboration with the distributors of the filled devices; inhalers sold filled with aerosol inhalation products, developed by or in collaboration with the distributors of the filled devices; pharmaceutical and biological preparations for inhalation for use in treatment of respiratory diseases and disorders; pharmaceutical and biological preparations for inhalation for use in treatment of cancer; pharmaceutical and biological preparations for use in the treatment of diabetes, osteoporosis, autoimmune disorders, and cancer; pharmaceutical and biological preparations for use with vaccinations; drug delivery systems composed of microneedles in the nature of needle-shaped microstructures sold filled with pharmaceutical and biological preparations developed by or in collaboration with the distributors of the filled devices.
(2) Inhalers for therapeutic and medical uses; chambers for inhalers; spacers for inhalers; apparatus for facilitating the inhalation of pharmaceutical preparations, namely dose counters, dose indicators, and metal canisters for use in inhalers; instruments and apparatus provided empty for the inhalation of pharmaceutical and biological preparations; drug delivery systems composed of microneedles in the nature of needle-shaped microstructures for use in delivery of pharmaceutical and biological preparations. (1) Custom manufacture of pharmaceutical preparations, biological preparations, drug delivery systems, and drug delivery agents for others.
(2) Research and development in the fields of biologics, pharmaceuticals, and medicine; research and development of new products for others; research and development of pharmaceutical preparations; research and development of biological preparations; research and development of drug delivery systems and devices; design for others in the field of pharmaceutical preparations; design for others in the field of biological preparations; design for others in the field of drug delivery systems and devices; testing of pharmaceutical preparations; testing of biological preparations; testing of drug delivery systems and devices.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
(1) Drug delivery agents in the form of transdermal patches, creams, gels, lotions, ointments, capsules, liquids, tablets, and oral transmucosals that facilitate the delivery of pharmaceutical and biological preparations; transdermal drug delivery patches for use in pain management; transdermal drug delivery patches for use in the treatment of osteoporosis, cardiac disorders, coronary artery disease, diabetes, menopausal symptoms, and central nervous system disorders; drug delivery devices, sold filled, for the subcutaneous and intradermal administration of pharmaceutical and biological preparations developed by or in collaboration with the distributors of the filled devices; inhalers sold filled with aerosol inhalation products, developed by or in collaboration with the distributors of the filled devices; pharmaceutical and biological preparations for inhalation for use in treatment of respiratory diseases and disorders; pharmaceutical and biological preparations for inhalation for use in treatment of cancer; pharmaceutical and biological preparations for use in the treatment of diabetes, osteoporosis, autoimmune disorders, and cancer; pharmaceutical and biological preparations for use with vaccinations; drug delivery systems composed of microneedles in the nature of needle-shaped microstructures sold filled with pharmaceutical and biological preparations developed by or in collaboration with the distributors of the filled devices.
(2) Inhalers for therapeutic and medical uses; chambers for inhalers; spacers for inhalers; apparatus for facilitating the inhalation of pharmaceutical preparations, namely dose counters, dose indicators, and metal canisters for use in inhalers; instruments and apparatus provided empty for the inhalation of pharmaceutical and biological preparations; drug delivery systems composed of microneedles in the nature of needle-shaped microstructures for use in delivery of pharmaceutical and biological preparations. (1) Custom manufacture of pharmaceutical preparations, biological preparations, drug delivery systems, and drug delivery agents for others.
(2) Research and development in the fields of biologics, pharmaceuticals, and medicine; research and development of new products for others; research and development of pharmaceutical preparations; research and development of biological preparations; research and development of drug delivery systems and devices; design for others in the field of pharmaceutical preparations; design for others in the field of biological preparations; design for others in the field of drug delivery systems and devices; testing of pharmaceutical preparations; testing of biological preparations; testing of drug delivery systems and devices.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
(1) Drug delivery agents in the form of transdermal patches, creams, gels, lotions, ointments, capsules, liquids, tablets, and oral transmucosals that facilitate the delivery of pharmaceutical and biological preparations; transdermal drug delivery patches for use in pain management; transdermal drug delivery patches for use in the treatment of osteoporosis, cardiac disorders, coronary artery disease, diabetes, menopausal symptoms, and central nervous system disorders; pharmaceutical and biological preparations for inhalation for use in treatment of respiratory diseases and disorders; pharmaceutical and biological preparations for inhalation for use in treatment of cancer; pharmaceutical and biological preparations for use in the treatment of diabetes, osteoporosis, autoimmune disorders, and cancer; pharmaceutical and biological preparations for use with vaccinations; microneedle drug delivery systems (term considered too vague by the International Bureau - Rule 13 (2) (b) of the Regulations); microsystems for delivery of pharmaceutical and biological preparations (term considered too vague by the International Bureau - Rule 13 (2) (b) of the Regulations).
(2) Inhalers for therapeutic and medical uses; chambers for inhalers; spacers for inhalers; apparatus for facilitating the inhalation of pharmaceutical preparations, namely dose counters, dose indicators, and metal canisters for use in inhalers; instruments and apparatus provided empty for the inhalation of pharmaceutical and biological preparation; inhalers filled with aerosol inhalation products; subcutaneous and intradermal drug delivery devices sold filled with pharmaceutical and biological preparations. (1) Custom manufacture of pharmaceutical preparations, biological preparations, drug delivery systems, and drug delivery agents for others.
(2) Research and development in the fields of biologics, pharmaceuticals, and medicine; research and development of new products for others; research and development of pharmaceutical preparations; research and development of biological preparations; research and development of drug delivery systems and devices; design for others in the field of pharmaceutical preparations; design for others in the field of biological preparations; design for others in the field of drug delivery systems and devices; testing of pharmaceutical preparations; testing of biological preparations; testing of drug delivery systems and devices.
78.
Microneedle injection and infusion apparatus and method of using same
A microneedle injection and infusion apparatus, and a method of using same. The apparatus can include a housing, a microneedle array holder for holding a microneedle array, and a shuttle that holds a cartridge (e.g., that contains an active agent). The microneedle array holder can be movable between a retracted position and an extended position. The shuttle can be movable between a first position in which the cartridge is not in fluid communication with a fluid path and a second position in which the cartridge is in fluid communication with the fluid path. The apparatus can further include an actuator movable between a first position and a second position. The method can include moving the actuator to its second position to allow the shuttle to move toward its second position, wherein movement of the shuttle toward its second position allows the microneedle array holder to move to its extended position.
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
A61M 5/142 - Perfusion sous pression, p. ex. utilisant des pompes
A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles
79.
Dose release firing systems and medicinal inhalers comprising same
A dose release firing system (101) for use in a medicinal inhaler (100). The firing system can include a plunger (103), and a stored energy device (109) configured to drive the plunger from a first position to a second position. The firing system can further include a guideway (121) and a projection (114) dimensioned to be received in the guideway, the guideway or the projection being fixedly coupled to the plunger. At least a portion of the guideway can have a helical shape, including a first portion with a first helix angle, and a second portion with a second helix angle, the second helix angle being less than the first helix angle. The projection and the guideway can be movable with respect to one another to cause the projection to be cammed along the guideway when the stored energy device drives the plunger to move from the first position to the second position.
An applicator and method for applying a microneedle array to skin. The applicator can include a body having a first portion and a second portion defining a cavity, the second portion having a slot presented on an outside surface for insertion of the microneedle array into the cavity. The first portion and the second portion are slidable relative to one other along an axis enabling the body to be in an unprimed configuration and a primed configuration. The applicator further includes a door operable with the second portion, the door being movable from a first door position to a second door position, wherein when the device is in the unprimed configuration, the door at least partially obstructs the slot and access into the cavity. When the device is in the primed configuration, the door does not obstruct the slots and enables access into the cavity.
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
81.
TRANSDERMAL SYSTEM FOR THE DELIVERY OF ABALOPARATIDE AND METHOD OF USE
Provided herein are methods for treating osteoporosis and increasing bone mass density, that includes administering once a day, for about 5 minutes, a transdermal patch loaded with about 300 µg of abaloparatide, and ZnCl2 at a molar ratio of 2.2:1 of ZnCl2:abaloparatide. Also provided are the single-use transdermal patches loaded with about 300 µg of abaloparatide, and ZnCl2 at a molar ratio of 2.2:1 of ZnCl2:abaloparatide.
Disclosed are abaloparatide formulations for transdermal delivery of a therapeutically effective amount of abaloparatide, as well as transdermal patches prepared using these formulations, methods of preparing the disclosed formulations and patches, and methods of using these formulations and patches to treat osteoporosis, osteopenia, osteoarthritis, and/or bone fracture, improve bone mineral density (BMD), improve trabecular bone score (TBS), and treat, prevent, and/or reduce bone fractures.
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Custom manufacture of pharmaceutical preparations, biological preparations, drug delivery systems, and drug delivery agents for others Research and development in the fields of biologics, pharmaceuticals, and medicine; research and development of new products for others; research and development of pharmaceutical preparations; research and development of biological preparations; research and development of drug delivery systems and devices; design for others in the field of pharmaceutical preparations; design for others in the field of biological preparations; design for others in the field of drug delivery systems and devices; testing of pharmaceutical preparations; testing of biological preparations; testing of drug delivery systems and devices
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Custom manufacture of pharmaceutical preparations, biological preparations, drug delivery systems, and drug delivery agents for others Research and development in the fields of biologics, pharmaceuticals, and medicine; research and development of new products for others; research and development of pharmaceutical preparations; research and development of biological preparations; research and development of drug delivery systems and devices; design for others in the field of pharmaceutical preparations; design for others in the field of biological preparations; design for others in the field of drug delivery systems and devices; testing of pharmaceutical preparations; testing of biological preparations; testing of drug delivery systems and devices
05 - Produits pharmaceutiques, vétérinaires et hygièniques
06 - Métaux communs et minerais; objets en métal
10 - Appareils et instruments médicaux
Produits et services
Drug delivery agents in the form of transdermal patches, creams, gels, lotions, ointments, capsules, liquids, tablets, and oral transmucosals that facilitate the delivery of pharmaceutical and biological preparations; transdermal drug delivery patches for use in pain management; transdermal drug delivery patches for use in the treatment of osteoporosis, cardiac disorders, coronary artery disease, diabetes, menopausal symptoms, and central nervous system disorders; drug delivery devices, sold filled, for the subcutaneous and intradermal administration of pharmaceutical and biological preparations for the treatment of a wide variety of conditions and that are developed by or in collaboration with the distributors of the filled devices; inhalers sold filled with aerosol inhalation products for the treatment of a wide variety of conditions and that are developed by or in collaboration with the distributors of the filled devices; pharmaceutical and biological preparations for inhalation for use in treatment of respiratory diseases and disorders; pharmaceutical and biological preparations for inhalation for use in treatment of cancer; pharmaceutical and biological preparations for use in the treatment of diabetes, osteoporosis, autoimmune disorders, and cancer; pharmaceutical and biological preparations for use with vaccinations; drug delivery systems composed of microneedles in the nature of needle-shaped microstructures sold with pharmaceutical and biological preparations filling or coating the microneedles intended for the treatment of a wide variety of conditions and that are developed by or in collaboration with the distributors of the filled devices Metal canisters, sold empty, for use in conjunction with inhalers Inhalers for therapeutic and medical uses; chambers for inhalers; spacers for inhalers; medical apparatus for facilitating the inhalation of pharmaceutical preparations, namely, dose counters, dose indicators for medical purposes, and metal canisters being a component of inhalers; instruments and apparatus provided empty for the inhalation of pharmaceutical and biological preparations; drug delivery systems composed of microneedles in the nature of needle-shaped microstructures, sold empty, for use in delivery of pharmaceutical and biological preparations
05 - Produits pharmaceutiques, vétérinaires et hygièniques
06 - Métaux communs et minerais; objets en métal
10 - Appareils et instruments médicaux
Produits et services
Drug delivery agents in the form of transdermal patches, creams, gels, lotions, ointments, capsules, liquids, tablets, and oral transmucosals that facilitate the delivery of pharmaceutical and biological preparations; transdermal drug delivery patches for use in pain management; transdermal drug delivery patches for use in the treatment of osteoporosis, cardiac disorders, coronary artery disease, diabetes, menopausal symptoms, and central nervous system disorders; drug delivery devices, sold filled, for the subcutaneous and intradermal administration of pharmaceutical and biological preparations for the treatment of a wide variety of conditions and that are developed by or in collaboration with the distributors of the filled devices; inhalers sold filled with aerosol inhalation products for the treatment of a wide variety of conditions and that are developed by or in collaboration with the distributors of the filled devices; pharmaceutical and biological preparations for inhalation for use in treatment of respiratory diseases and disorders; pharmaceutical and biological preparations for inhalation for use in treatment of cancer; pharmaceutical and biological preparations for use in the treatment of diabetes, osteoporosis, autoimmune disorders, and cancer; pharmaceutical and biological preparations for use with vaccinations; drug delivery systems composed of microneedles in the nature of needle-shaped microstructures sold with pharmaceutical and biological preparations filling or coating the microneedles intended for the treatment of a wide variety of conditions and that are developed by or in collaboration with the distributors of the filled devices Metal canisters, sold empty, for use in conjucntion with inhalers Inhalers for therapeutic and medical uses; chambers for inhalers; spacers for inhalers; medical apparatus for facilitating the inhalation of pharmaceutical preparations, namely, dose counters, dose indicators for medical purposes, and metal canisters being a component of inhalers; instruments and apparatus provided empty for the inhalation of pharmaceutical and biological preparations; drug delivery systems composed of microneedles in the nature of needle-shaped microstructures, sold empty, for use in delivery of pharmaceutical and biological preparations
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Custom manufacture of pharmaceutical preparations, biological preparations, drug delivery systems, and drug delivery agents for others Research and development in the fields of biologics, pharmaceuticals, and medicine; research and development of new products for others; research and development of pharmaceutical preparations; research and development of biological preparations; research and development of drug delivery systems and devices; design for others in the field of pharmaceutical preparations; design for others in the field of biological preparations; design for others in the field of drug delivery systems and devices; testing of pharmaceutical preparations; testing of biological preparations; testing of drug delivery systems and devices
05 - Produits pharmaceutiques, vétérinaires et hygièniques
06 - Métaux communs et minerais; objets en métal
10 - Appareils et instruments médicaux
Produits et services
Drug delivery agents in the form of transdermal patches, creams, gels, lotions, ointments, capsules, liquids, tablets, and oral transmucosals that facilitate the delivery of pharmaceutical and biological preparations; transdermal drug delivery patches for use in pain management; transdermal drug delivery patches for use in the treatment of osteoporosis, cardiac disorders, coronary artery disease, diabetes, menopausal symptoms, and central nervous system disorders; drug delivery devices, sold filled, for the subcutaneous and intradermal administration of pharmaceutical and biological preparations for the treatment of a wide variety of conditions and that are developed by or in collaboration with the distributors of the filled devices; inhalers sold filled with aerosol inhalation products for the treatment of a wide variety of conditions and that are developed by or in collaboration with the distributors of the filled devices; pharmaceutical and biological preparations for inhalation for use in treatment of respiratory diseases and disorders; pharmaceutical and biological preparations for inhalation for use in treatment of cancer; pharmaceutical and biological preparations for use in the treatment of diabetes, osteoporosis, autoimmune disorders, and cancer; pharmaceutical and biological preparations for use with vaccinations; drug delivery systems composed of microneedles in the nature of needle-shaped microstructures sold with pharmaceutical and biological preparations filling or coating the microneedles intended for the treatment of a wide variety of conditions and that are developed by or in collaboration with the distributors of the filled devices Metal canisters, sold empty, for use in conjunction with inhalers Inhalers for therapeutic and medical uses; chambers for inhalers; spacers for inhalers; medical apparatus for facilitating the inhalation of pharmaceutical preparations, namely, dose counters, dose indicators for medical purposes, and metal canisters being a component of inhalers; instruments and apparatus provided empty for the inhalation of pharmaceutical and biological preparations; drug delivery systems composed of microneedles in the nature of needle-shaped microstructures, sold empty, for use in delivery of pharmaceutical and biological preparations
An inhaler (60) has a breath actuated trigger mechanism (100) reactive to an inhalation flow to trigger the release of a substance to be inhaled. The inhaler (60) has an inspiration flow which is subject to a higher degree of flow governing post-triggering than pre-triggering. This allows the triggering flow rate to be closer to, or even higher than, the governing flow rate of the inhaler.
Formulations containing pharmaceutical active agent, propellant, and water at least partially adsorbed on or absorbed within one or more nylon pellets or nylon components of, for example, an inhaler such as a metered dose inhaler. Canisters, typically sealed canisters, containing such formulations. Inhalers, such as metered dose inhalers, containing such canisters. Methods of making and using the same.
A61K 31/137 - Arylalkylamines, p. ex. amphétamine, épinéphrine, salbutamol, éphédrine
A61K 31/46 - Aza-8-bicyclo[3.2.1]octaneSes dérivés, p. ex. atropine, cocaïne
A61K 47/06 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite
A61K 47/34 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyesters, acides polyaminés, polysiloxanes, polyphosphazines, copolymères de polyalkylène glycol ou de poloxamères
92.
Medicinal inhaler comprising a lockout override mechanism
A refill assembly configured to be removably coupled to a reusable assembly of a medicinal inhaler is disclosed and includes a patient port, a canister actuable by the reusable assembly to deliver a dose of medicament to the patient port, and a sleeve which is selectively actuable by a user independently of the reusable assembly so as to act on the canister to deliver a dose of medicament. The refill assembly further includes an override element which engages the sleeve, the override element being moveable from a first position in which the sleeve is retained in a first position by the override element and a second position in which the sleeve is permitted to move to a second position upon depression of the sleeve by a user to cause a dose of medicament to be delivered to the patient port.
A valved-container inhaler (150) has a mechanical return assembly with a spring (214) and a transfer (212) configured to transfer stored potential energy from the spring to a canister (51) and a clutch (208, 210) in a load path of the force between the spring and the transfer, the clutch being rotatable between a first condition in which load is transferred from the spring to the transfer, and a second condition in which the spring and the transfer can move relative to one another to interrupt the load path and thereby allow the canister to resile after actuation.
An inhaler has a housing having a patient port and a cover rotatable about a cover axis between a closed position in which the cover covers the patient port, and an open position in which the patient port is accessible, a spring surrounding a medicament container in which the cover axis intersects the container, and in which the cover is configured to drive the resilient structure to store energy therein upon rotation from the closed position towards the open position.
A breath-responsive metered dose inhaler having a trigger mechanism for triggering delivery of a medicament and a trigger mechanism chassis for locating the trigger mechanism within the inhaler, the trigger mechanism including a breath responsive member moveable upon inhalation of the user from a primed position in which the inhaler is prevented from delivering medicament, to a triggered position in which the medicament is delivered to the user, a spring which is flexible along its longitudinal axis, wherein the spring is configured to bias the breath responsive member from its triggered position to its primed position by flexure along its longitudinal axis.
A breath-responsive inhaler having a trigger mechanism for triggering delivery of a medicament to a user, the trigger mechanism including a medicament source, having a primed position in which the inhaler is primed for use and an actuated position in which the medicament source is actuated to dispense a dose of medicament, a toggle mechanism for selectively permitting movement of the source from its primed position to its actuated position, the toggle mechanism comprising a vane positioned in the air flow path, the vane being pivoted about a vane pivot, and wherein the trigger mechanism is triggered by movement of the vane upon inhalation of the user to move the toggle mechanism between a primed condition in which the medicament source is maintained in its primed position by cooperation with the toggle mechanism and an actuated condition in which the toggle mechanism is disengaged from cooperation with the medicament source.
The present disclosure provides a method of preparing a pharmaceutical composition. The method includes transferring a predetermined quantity of an excipient mixture from a second vessel to a first vessel. The excipient mixture transferred from the second vessel includes a liquid-state second quantity of a hydrofluoroalkane propellant and a first solubilized excipient comprising a low-molecular weight poly(ethylene oxide) polymer. The method further includes contacting at least one pharmaceutically-active compound with the excipient mixture under conditions that facilitate forming an intermixture comprising the propellant, the polymer, and the compound. Before transferring the excipient mixture, the first vessel contains a vapor-phase first quantity of the hydrofluoroalkane propellant and an effective amount of the at least one pharmaceutically-active compound.
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
A61K 47/32 - Composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. carbomères
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
A61K 9/46 - Pilules, pastilles ou comprimés effervescents
A61K 31/137 - Arylalkylamines, p. ex. amphétamine, épinéphrine, salbutamol, éphédrine
A61K 31/167 - Amides, p. ex. acides hydroxamiques ayant des cycles aromatiques, p. ex. colchicine, aténolol, progabide ayant l'atome d'azote d'un groupe carboxamide lié directement au cycle aromatique, p. ex. lidocaïne, paracétamol
A61K 31/58 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes contenant des hétérocycles, p. ex. danazol, stanozolol, pancuronium ou digitogénine
A61K 47/06 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite
B65B 31/00 - Emballage d'objets ou de matériaux dans des conditions atmosphériques ou gazeuses particulièresAddition de propergols à des réceptacles pour aérosols
99.
Article comprising a microneedle and methods of use
An article comprising at least one microneedle is provided. The article can comprises a first side and a second side opposite the first side. The first side comprises a central cavity portion and a platform portion, with at least one microneedle extending therefrom, wherein the platform portion is not coplanar with the central cavity portion. The platform portion substantially surrounds the central cavity portion. The at least one microneedle comprises a body comprising an outer surface; a base segment having a base and a first shape; a tip segment having a tip and a second shape, wherein the second shape is distinct from the first shape; a transition plane that delineates the base segment and the tip segment; and a central axis. Methods of using the article are also provided.
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
100.
Formulations of abaloparatide, transdermal patches thereof, and uses thereof
Disclosed are abaloparatide formulations for transdermal delivery of a therapeutically effective amount of abaloparatide, as well as transdermal patches prepared using these formulations, methods of preparing the disclosed formulations and patches, and methods of using these formulations and patches to treat osteoporosis, osteopenia, osteoarthritis, and/or bone fracture, improve bone mineral density (BMD), improve trabecular bone score (TBS), and treat, prevent, and/or reduce bone fractures.
