Abrégé

Methods and systems for identifying and detecting DNA methylation-based biomarkers for cancer in cell-free DNA in liquid biopsy, more specifically, to methods and systems for identifying methylation-based biomarkers for hepatocellular carcinoma and detecting hepatocellular carcinoma, using bioinformatic tools.

Classes IPC  ?

• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
• G16B 20/20 - Détection d’allèles ou de variantes, p. ex. détection de polymorphisme d’un seul nucléotide
• G12Q 1/6837 -

Abrégé

The present invention relates to nanobodies and nanobody constructs capable of recognizing and binding EGFR, and related methods that use thereof, for example methods of diagnosis, treatment and theragnosis that comprise the use of said nanobodies and nanobody constructs.

Classes IPC  ?

• C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
• A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps

Abrégé

The present invention relates to bioinformatic tools for identifying DNA methylation- based biomarkers and methods for detecting these biomarkers in blood samples of colorectal cancer (CRC) patients. Accordingly, the present invention provides an algorithm for selecting methylation biomarkers and a hemi-probe system for detection of multiple methylation biomarkers in liquid biopsy from CRC patients using restriction enzyme-based amplification. The present invention further discloses a colorectal cancer detection panel comprising CpG sites of 15 methylated-based biomarkers.

Classes IPC  ?

• G16B 20/20 - Détection d’allèles ou de variantes, p. ex. détection de polymorphisme d’un seul nucléotide
• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
• C12N 9/12 - Transférases (2.) transférant des groupes contenant du phosphore, p. ex. kinases (2.7)
• C12N 9/22 - Ribonucléases
• C12Q 1/6813 - Tests d’hybridation
• C12Q 1/6851 - Amplification quantitative
• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer

Abrégé

The present invention describes a fertilizer composition comprising phosphate nanoparticles and at least two nitrogen sources selected from a group consisting of urea, nitrate, ammonium and their combinations; and a process for obtaining said composition. In addition, it is described a method for stimulating crop growth that includes the use of the fertilizer composition, which allows increasing yield and the nitrogen use efficiency.

Classes IPC  ?

• C05C 1/00 - Engrais de nitrate d'ammonium
• C05G 3/90 - Mélanges d'un ou plusieurs engrais avec des additifs n'ayant pas une activité spécifique d'engrais pour influer sur la nitrification des composés d’ammonium ou de l’urée dans le sol
• C05C 9/00 - Engrais contenant de l'urée ou ses composés
• C05G 5/20 - Engrais liquides
• A01C 21/00 - Méthodes de fertilisation

Abrégé

An isoform of the TGF beta receptor II having a sequence of about of 80 amino acids and lacking a transmembrane domain. The isoform having the amino acid sequence set forth in SEQ ID No. 12. The isoform may have the amino acid sequence set forth in SEQ ID No. 2 or sequences having at least 85% sequence identity to the sequence set forth in SEQ ID No. 2. A fusion peptide is provided having an isoform of the TGF beta II receptor fused to a ligand, wherein a vector having the fusion peptide is used to treat cancer and/or hepatic fibrosis. An antibody binding the soluble isoform of the TGF beta II receptor is provided. The antibody binds the amino acid sequence shown in SEQ ID No. 12 and is used in in vitro methods.

Classes IPC  ?

• C07K 14/71 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire pour des facteurs de croissanceRécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire pour des régulateurs de croissance
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 9/51 - Nanocapsules
• A61K 38/00 - Préparations médicinales contenant des peptides
• A61P 1/16 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des troubles de la vésicule biliaire ou du foie, p. ex. protecteurs hépatiques, cholagogues, cholélitholytiques
• A61P 35/00 - Agents anticancéreux
• C07K 16/00 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux
• C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
• C12N 7/00 - Virus, p. ex. bactériophagesCompositions les contenantLeur préparation ou purification
• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

Lipid nanoparticles that can be used as active molecule carriers for ophthalmic, dermatological, and/or cosmetic applications. The nanoparticles have an average particle size of less than 80 nm and a permeation enhancer that provides high therapeutic efficacy when applied via ophthalmic or cutaneous routes. The lipid nanoparticles may comprise solid lipids -at room temperature- such as cocoa butter and glyceryl distearate, liquid lipids such as Linoleoyl Polyoxyl-6 glycerides and/or Oleoyl Polyoxyl-6 glycerides, and non-ionic surfactants such as Polyethylene glycol 660 12-hydroxystearate and Polysorbate 80. The lipid nanoparticles can be loaded with active molecules, such as dexamethasone, triamcinolone, prednisolone, betamethasone, dexamethasone sodium phosphate, curcumin, cisplatin, mesalamine, doxorubicin, indomethacin, celecoxib, N- palmitoyl-ethanolamine, timolol maleate, flurbiprofen, ibuprofen, levofloxacin, tobramycin, among others. Moreover, the procedure for obtaining the lipid nanoparticles is carried out without the use of organic solvents and by applying low energy.

Classes IPC  ?

• A61K 8/14 - Liposomes
• A61K 9/51 - Nanocapsules
• A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone substitués en position 21, p. ex. cortisone, dexaméthasone, prednisone ou aldostérone
• A61K 47/14 - Esters d’acides carboxyliques, p. ex. acides gras monoglycérides, triglycérides à chaine moyenne, parabènes ou esters d’acide gras de PEG
• A61P 27/02 - Agents ophtalmiques
• A61P 35/00 - Agents anticancéreux
• B82B 1/00 - Nanostructures formées par manipulation d’atomes ou de molécules, ou d’ensembles limités d’atomes ou de molécules un à un comme des unités individuelles
• B82B 3/00 - Fabrication ou traitement des nanostructures par manipulation d’atomes ou de molécules, ou d’ensembles limités d’atomes ou de molécules un à un comme des unités individuelles

Abrégé

P. pastorisP. pastoris. Among others, the amino acid sequence of the RBD domain may be the sequence set forth in SEQ ID NO. 1 or SEQ ID NO. 2, wherein the vaccine may further comprise one or more adjuvants.

Classes IPC  ?

• A61K 39/215 - Coronaviridae, p. ex. virus de la bronchite infectieuse aviaire
• A61K 39/39 - Préparations médicinales contenant des antigènes ou des anticorps caractérisées par les additifs immunostimulants, p. ex. par les adjuvants chimiques
• C12N 7/00 - Virus, p. ex. bactériophagesCompositions les contenantLeur préparation ou purification

Abrégé

A detector of thermal neutrons, fast neutrons and gamma photons that is based on a Cherenkov radiation detector in water and that allows large active volumes of detection at a relatively low cost and higher intensity signals, wherein said detector comprises a container comprising at least a lid; a photon reflective and diffusive coating inside the container; an aqueous solution contained in the container, which comprises sodium chloride (NaCl); and a light sensing device optically coupled to the aqueous solution.

Classes IPC  ?

• G01T 1/22 - Mesure de l'intensité de radiation avec des détecteurs Cerenkov
• G01T 3/00 - Mesure de flux de neutrons

Abrégé

A bioabsorbable membrane for tissue regeneration comprising: poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), polyvinylpyrrolidone-vinyl acetate (PVP) and poly(lactide-co-glycolide (PLGA). The membrane comprises from 65 to 80 wt% of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), from 4 to 15 wt% of polyvinylpyrrolidone-vinyl acetate (PVP) copolymer and from 0.5 to 10 wt% of poly(lactide-co-glycolide (PLGA) and from 4 to 10 wt% of a surfactant.

Classes IPC  ?

• A61C 8/02 - Moyens pour la transfixation des dents naturelles
• A61F 2/28 - Os
• A61L 27/06 - Titane ou alliages de titane

Abrégé

The present invention describes a method to improve the agronomic characteristics of plants that comprises genetically transforming said plant with a nucleic acid sequence encoding RAMOSA1 transcription factor, where said plant is selected from the group consisting of gramineous monocotyledons of the BOP clade, monocotyledons-non-grasses and dicotyledons. In addition, sequences of DNA, cDNA, protein, cells, uses, genetic transformation method of plants and transformed plants are described.

Classes IPC  ?

• C12N 15/82 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules végétales
• C12N 5/14 - Cellules végétales
• C12N 5/04 - Cellules ou tissus végétaux
• C12N 15/29 - Gènes codant pour des protéines végétales, p. ex. thaumatine
• C12N 15/70 - Vecteurs ou systèmes d'expression spécialement adaptés à E. coli
• A01H 1/00 - Procédés de modification des génotypes

Abrégé

A method of treating Triple Negative Breast Cancer in a subject, which comprises delivering a nucleic acid sequence encoding a mutant Erb B-2 polypeptide in an amount effective to inhibit cancer cell proliferation, wherein the mutant Erb B-2 lacks a functional nuclear localization signal, cannot translocate to the nucleus of the cell in which it is present, and functions as a dominant-negative inhibitor of endogenous Erb B-2 by inhibiting nuclear translocation of endogenous Erb B-2 in the cell in which the mutant is present, wherein the mutant Erb B-2 polypeptide retains intrinsic tyrosine kinase activity and does not inhibit endogenous Erb B-2 tyrosine kinase activity.

Classes IPC  ?

• A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
• A61K 38/45 - Transférases (2)
• A61P 35/00 - Agents anticancéreux
• A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique
• A61K 31/704 - Composés ayant des radicaux saccharide liés à des composés non-saccharide par des liaisons glycosidiques liés à un composé carbocyclique, p. ex. phloridzine liés à un système carbocyclique condensé, p. ex. sennosides, thiocolchicosides, escine, daunorubicine, digitoxine

Abrégé

A thermal neutron, fast neutron and gamma photon detector based on a water Cherenkov detector and which allows large active detection volumes at a relatively low cost and higher-intensity signals, wherein said detector comprises a receptacle which comprises at least one lid; a coating that reflects and diffuses photons in the interior of the receptacle; an aqueous solution contained in the receptacle which comprises sodium chloride (NaCl); and a light sensor device optically coupled to the aqueous solution.

Classes IPC  ?

• G01T 1/20 - Mesure de l'intensité de radiation avec des détecteurs à scintillation
• G01T 3/06 - Mesure de flux de neutrons avec des détecteurs à scintillation
• G01T 1/22 - Mesure de l'intensité de radiation avec des détecteurs Cerenkov
• G01T 3/00 - Mesure de flux de neutrons

Abrégé

A method for modulating angiogenesis in a cancer or tumor refractory to anti-VEGF, including identifying a cancer cell as being referactory to anti-VEGF, and then contacting the cancer cell refractory to anti-VEGF with an effective amount of an agent that modulates interaction between Gal1 or a Gal1 fragment and the natural binding partner of Gal1 or the Gal1 fragment to thereby modulate angiogenesis.

Classes IPC  ?

• A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
• C07K 16/18 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains
• C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
• C07K 16/22 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des facteurs de croissance
• C07K 16/30 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire provenant de cellules de tumeurs
• A61K 35/00 - Préparations médicinales contenant des substances ou leurs produits de réaction de constitution non déterminée
• A61P 35/00 - Agents anticancéreux
• A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps

Abrégé

2 with at least one acid. The method allows achieving an economically viable complete recycling process with low environmental impact.

Classes IPC  ?

• B09B 3/00 - Destruction de déchets solides ou transformation de déchets solides en quelque chose d'utile ou d'inoffensif
• C22B 26/12 - Obtention du lithium
• C22B 3/16 - Extraction de composés métalliques par voie humide à partir de minerais ou de concentrés par lixiviation dans des solutions organiques
• H01M 10/54 - Récupération des parties utiles des accumulateurs usagés
• C22B 1/00 - Traitement préliminaire de minerais ou de débris ou déchets métalliques
• C22B 7/00 - Mise en œuvre de matériaux autres que des minerais, p. ex. des rognures, pour produire des métaux non ferreux ou leurs composés
• C22B 3/00 - Extraction de composés métalliques par voie humide à partir de minerais ou de concentrés

Abrégé

Galectin-1 polypeptide variants that include a mutation of the histidine residue corresponding to position 52 of the full-length amino acid sequence of native human Gal-1 as shown in SEQ ID NO: 1, the mutation being a substitution of the histidine to tyrosine or asparagine, providing resistance to acidosis otherwise resulting in deactivation of the native human Gal-1. The Galectin-1 polypeptide variants may include one or more additional mutation(s) of the cysteine residue corresponding to a position selected from 2, 16, 88, or combinations thereof of the full-length amino acid sequence of native human Gal-1 as shown in SEQ ID NO: 1, the additional mutation being a substitution of the cysteine to serine, and providing resistance to oxidation.

Classes IPC  ?

• A61K 38/00 - Préparations médicinales contenant des peptides
• C07K 14/705 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire

Abrégé

The invention relates to a single-needle device for the treatment of deep tumours by means of electrochemotherapy, the device comprising an electrically insulated central needle with an electrically conductive plate or electrode on each side, wherein the electrodes are connected to an electroporator. The device allows the treatment of deep tumours, using a single needle, which minimises the invasion of the tissue, keeps both electrodes parallel, allows the field applied to be predicted, and the device can be guided by ecography, tomography or magnetic resonance. All this contributes to the considerable simplifcation of the treatment.

Classes IPC  ?

• A61N 1/04 - Électrodes
• A61N 1/32 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents

Abrégé

A detector of thermal and subthermal neutrons with high spatial resolution in two dimensions, based on an electronic image forming sensor (for example a CCD or CMOS device). The detector possesses as small size, low consumption, is portable and of very low cost. The detector does not utilize the scarce and expensive 3He isotope, and be mass-produced. It can be used for defense, security, and control posts in borders and traffic, detecting the presence of fissile materials, such as plutonium or uranium; in dosimetry in radiotherapy treatments based on the use of neutrons; and in various techniques which employ neutron beams for numerous basic and applied studies, among other applications. It also has environmental applications, controlling contamination by materials that emit thermal neutrons, inspection of materials by neutron radiography (imaging using neutrons) and in general in physics and engineering of reactors and nuclear physics and engineering.

Classes IPC  ?

• G01T 3/08 - Mesure de flux de neutrons avec des détecteurs à semi-conducteurs

Abrégé

A process for producing propylene glycol from glycerol including a catalyst of Cu and Ce at concentrations of up to 15% of each metal. In addition, it is described a catalyst of Cu and Ce to perform the selective reduction of glycerol and the process of production of such catalyst.

Classes IPC  ?

• B01J 23/10 - Catalyseurs contenant des métaux, oxydes ou hydroxydes métalliques non prévus dans le groupe des terres rares
• B01J 23/83 - Catalyseurs contenant des métaux, oxydes ou hydroxydes métalliques non prévus dans le groupe du cuivre ou des métaux du groupe du fer en combinaison avec des métaux, oxydes ou hydroxydes prévus dans les groupes avec des terres rares ou des actinides
• B01J 37/02 - Imprégnation, revêtement ou précipitation
• C07C 29/60 - Préparation de composés comportant des groupes hydroxyle ou O-métal liés à un atome de carbone ne faisant pas partie d'un cycle aromatique à six chaînons par élimination de groupes hydroxyle, p. ex. par déshydratation
• B01J 35/02 - Catalyseurs caractérisés par leur forme ou leurs propriétés physiques, en général solides
• B01J 37/08 - Traitement thermique
• B01J 35/00 - Catalyseurs caractérisés par leur forme ou leurs propriétés physiques, en général
• B01J 23/00 - Catalyseurs contenant des métaux, oxydes ou hydroxydes métalliques non prévus dans le groupe

Abrégé

A method is disclosed for producing spherical particles of mesoporous metal oxides having a controlled composition, surface area and porosity, comprising the preparation of a stable dispersion (sol) of transition metal oxide precursor species in a water-based solvent system, followed by aerosol drying and a controlled thermal treatment.

Classes IPC  ?

• C01G 23/047 - Dioxyde de titane
• C01G 25/02 - Oxydes
• C01B 13/34 - Méthodes de préparation des oxydes ou hydroxydes en général par oxydation ou hydrolyse de solutions pulvérisées ou atomisées
• C01F 17/00 - Composés des métaux des terres rares

Abrégé

An electronic device to automate an electric wheelchair, where the wheelchair is capable of accepting commands coming from a computer and moving according to these commands. The device of the invention emulates the commands sent by a wheelchair joystick. Thus, a commercial wheelchair with joystick can be driven by speed and direction digital commands coming from a computer. On the computer, Human-Machine Interfaces can be implemented, useful to help people with disabilities who cannot command a wheelchair by means of a joystick but are able to take decisions regarding the direction and speed they want to apply to the chair. The device comprises at least four modules, a main module controlled by a microcontroller, a digital/analogic conversion module, a module for communication between a computer and said microcontroller, and a module responsible of actuating joystick switches.

Classes IPC  ?

• A61G 5/04 - Fauteuils ou moyens de transport personnels spécialement adaptés pour des personnes handicapées, p. ex. fauteuils roulants à moteur
• B60L 15/00 - Procédés, circuits ou dispositifs pour commander la propulsion des véhicules à traction électrique, p. ex. commande de la vitesse des moteurs de traction en vue de réaliser des performances désiréesAdaptation sur les véhicules à traction électrique de l'installation de commande à distance à partir d'un endroit fixe, de différents endroits du véhicule ou de différents véhicules d'un même train
• A61G 5/10 - Parties constitutives, détails ou accessoires

Abrégé

The invention relates to a multiple-friction device for dissipating energy, which can be used to control the dynamic response in terms of displacements and accelerations, and which comprises at least one column surrounded by a set of multiple-friction members which are in contact with same and are secured together by means of securing pins. The device further comprises at least one axial load adjuster mounted on a plurality of compression springs, the adjuster being secured by means of high-strength screws. The device does not have the disadvantages of the implementation of traditional friction dissipators, and can be used in both new and renovated structures.

Classes IPC  ?

• E04H 9/02 - Bâtiments, groupes de bâtiments ou abris conçus pour résister à des situations extérieures anormales, p. ex. à des bombardements, à des séismes ou à des climats extrêmes, ou pour se protéger de ces situations résistant aux séismes ou à l'effondrement du sol

Abrégé

The invention relates to a device for studying the evolution of the magnetic and structural properties of soft amorphous and nanocrystalline magnetic materials, said device being characterised in that it comprises at least one first group of windings for determining hysteresis cycles, at least one second group of windings for determining magnetic permeability, an arrangement for holding the sample in the form of a belt, an energy source for the annealed products, a current and/or voltage amplifier, an associated hardware and a software. The invention relates to a method for studying the evolution of the magnetic and structural properties of soft amorphous and nanocrystalline magnetic materials, which, combined with the use of the device, allows the almost simultaneous measurement of various properties (currently we can mention three magnetic properties and one electrical one at ambient temperature and at high temperature almost simultaneously).

Classes IPC  ?

• G01R 33/12 - Mesure de propriétés magnétiques des articles ou échantillons de solides ou de fluides
• G01R 33/14 - Mesure ou tracé par points des courbes d'hystérésis
• G01R 33/16 - Mesure de la susceptibilité
• G01R 33/18 - Mesure des propriétés de magnétostriction

Abrégé

The invention relates to a method for the acid dissolution of the LiCoO2 contained in the cathode of lithium-ion batteries, using acetic acid or tartaric acid as a leaching agent, the method being characterised in that it comprises a first step and a second step, where said first step comprises the separation of the components from the cathode, while the second step comprises the dissolution of the pure LiCoO2 with at least one acid. The method allows the achievement of a complete recycling process which has a low environmental impact and is economically viable.

Classes IPC  ?

• H01M 10/54 - Récupération des parties utiles des accumulateurs usagés
• B09B 3/00 - Destruction de déchets solides ou transformation de déchets solides en quelque chose d'utile ou d'inoffensif
• C22B 1/00 - Traitement préliminaire de minerais ou de débris ou déchets métalliques
• C22B 7/00 - Mise en œuvre de matériaux autres que des minerais, p. ex. des rognures, pour produire des métaux non ferreux ou leurs composés
• C22B 26/12 - Obtention du lithium

Abrégé

Reinforced and isolated resin panel for protection of structures against near field blast loadings, the panel comprising at least a first stratum, at least a second stratum, at least a third stratum and a separating means, where the first stratum is a resin plate, the at least one second stratum is a metallic mesh, the at least one third stratum is a metallic plate jacket and the separating means defines a separation zone between the panel and a structure to be protected. The panel may be installed as independent layers, so as to produce strong collisions between the different resin layers and increasing fracture surfaces. The panel is particularly useful for protecting columns of buildings exposed to intentional or accidental blasts, where the focus of the blast loading is located very near the column and consequently the building could be exposed to progressive collapse. The panel system can be adapted to any type of column cross section and it also allows for the protection of masonry walls, and concrete shear walls and slabs.

Classes IPC  ?

• F41H 5/04 - Structure des plaques composées de plus d'une couche
• F41H 5/24 - BlindagePlaques de blindageBoucliers à usage statique, p. ex. dans les fortifications

Abrégé

A method for modulating angiogenesis in a cancer or tumor refractory to anti-VEGF, including identifying a cancer cell as being referactory to anti-VEGF, and then contacting the cancer cell refractory to anti-VEGF with an effective amount of an agent that modulates interaction between Gal1 or a Gal1 fragment and the natural binding partner of Gal1 or the Gal1 fragment to thereby modulate angiogenesis.

Classes IPC  ?

• C07K 16/30 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire provenant de cellules de tumeurs
• C07K 16/22 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des facteurs de croissance
• C07K 16/18 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains
• A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
• C07K 16/26 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des hormones
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps

Abrégé

The invention relates to a structural colouration method for colouring an aluminium substrate, which comprises forming a nano structure of one-dimensional photonic crystals by means of a process of periodic current pulse anodisation, the colour obtained depending on the application time of the maximum and/or minimum current density of the pulse, and the colour varying with the angle of observation.

Classes IPC  ?

• C25D 11/02 - Anodisation
• C25D 11/08 - Anodisation de l'aluminium ou de ses alliages caractérisée par les électrolytes utilisés contenant des acides inorganiques
• C25D 11/10 - Anodisation de l'aluminium ou de ses alliages caractérisée par les électrolytes utilisés contenant des acides organiques
• C25D 11/12 - Anodisation en plusieurs étapes, p. ex. dans différents bains
• C25D 11/16 - Prétraitement
• C25D 11/20 - Post-traitement électrolytique
• C25D 11/22 - Post-traitement électrolytique pour produire des couches colorées
• C25D 11/14 - Production de couches colorées en totalité

Abrégé

The invention relates to a system for the non-invasive measurement of blood glucose levels. The system is based on a sensor of the invention. The user presses their finger on said sensor, which is stimulated by means of a radiofrequency sweep generator. The magnitude and phase responses according to the frequency of the reflected wave are measured by an amplitude and phase detector. Said magnitudes are acquired by two analog-to-digital converters of a microcontroller, which, in turn, can transmit the magnitudes to other devices such as, for example, a computer or a smartphone.

Classes IPC  ?

• A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
• A61B 5/05 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus

Abrégé

Process for obtaining lithium compounds and intermediate compounds, comprising the following steps: a) contacting aluminosilicate particles, for example α-spodumene, with at least one fluorine compound, for example HF, NaF or others; b) stirring the mixture increasing the temperature until reaching an appropriate temperature; c) carrying out at least a precipitation and filtration process of the mixture of step b), and, d) recovering the lithium compound. The process may comprise using HF at a concentration between 5 and 30% v/v or NaF at a concentration between 5 and 30% w/v; a solid/liquid ratio of step a) between 0.9 and 14.4% w/v; a particle size of between 29 and 200 μm. The final lithium product of the process may be lithium carbonate or lithium fluoride.

Classes IPC  ?

• C01D 15/08 - CarbonatesBicarbonates
• C01D 15/04 - Halogénures
• C22B 3/06 - Extraction de composés métalliques par voie humide à partir de minerais ou de concentrés par lixiviation dans des solutions inorganiques acides
• C22B 3/12 - Extraction de composés métalliques par voie humide à partir de minerais ou de concentrés par lixiviation dans des solutions inorganiques alcalines

Abrégé

Disclosed is an ionising-particle detector which uses, for detection, a CMOS image sensor based on active-pixel sensors, the detector comprising a CMOS image sensor and an image processing unit, wherein the image processing unit eliminates fixed pattern noise (FPN), detects contiguous pixels with values above the threshold, calculates the charge generated, and emits the quantity of total charge as a result. The particle detector is based on an FPN-resistant technique. The technique allows any APS-based CMOS image sensor to be used to detect ionising particles, with a very low number of false detections caused by FPN.

Classes IPC  ?

• G01T 1/24 - Mesure de l'intensité de radiation avec des détecteurs à semi-conducteurs

Abrégé

A chimeric polypeptide containing a fragment of MSA-2c antigen bound to a fragment of RAP-1 antigen bound to a fragment of HSP20 antigen, where the antigens are antigens of a Babesia genus parasite. For example, the chimeric polypeptide may be represented by an amino acid sequence which contains at least 89% identity in relation to SEQ ID N° 1. It shows a composition for a vaccine against babesiosis, immunization methods and detection methods.

Classes IPC  ?

• C07K 14/44 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de protozoaires
• A61K 39/018 - Antigènes de Babesia, p. ex. antigènes de Theileria

Abrégé

Galectin-1 polypeptide variants that include a mutation of the histidine residue corresponding to position 52 of the full-length amino acid sequence of native human Gal-1 as shown in SEQ ID NO: 1, the mutation being a substitution of the histidine to tyrosine or asparagine, providing resistance to acidosis otherwise resulting in deactivation of the native human Gal-1. The Galectin-1 polypeptide variants may include one or more additional mutation(s) of the cysteine residue corresponding to a position selected from 2, 16, 88, or combinations thereof of the full-length amino acid sequence of native human Gal-1 as shown in SEQ ID NO: 1, the additional mutation being a substitution of the cysteine to serine, and providing resistance to oxidation.

Classes IPC  ?

• A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
• A61P 37/02 - Immunomodulateurs
• A61P 37/06 - Immunosuppresseurs, p. ex. médicaments pour le traitement du rejet de greffe
• A61P 37/08 - Agents antiallergiques
• C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
• C12N 5/078 - Cellules du sang ou du système immunitaire
• C12N 15/12 - Gènes codant pour des protéines animales

Abrégé

Galectin-1 polypeptide variants that include a mutation of the histidine residue corresponding to position 52 of the full-length amino acid sequence of native human Gal-1 as shown in SEQ ID NO: 1, the mutation being a substitution of the histidine to tyrosine or asparagine, providing resistance to acidosis otherwise resulting in deactivation of the native human Gal-1. The Galectin-1 polypeptide variants may include one or more additional mutation(s) of the cysteine residue corresponding to a position selected from 2, 16, 88, or combinations thereof of the full-length amino acid sequence of native human Gal-1 as shown in SEQ ID NO: 1, the additional mutation being a substitution of the cysteine to serine, and providing resistance to oxidation.

Classes IPC  ?

• A61K 38/16 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés
• A61K 35/16 - Plasma sanguinSérum sanguin
• A61P 37/06 - Immunosuppresseurs, p. ex. médicaments pour le traitement du rejet de greffe
• A61P 37/08 - Agents antiallergiques

Abrégé

Bi-structured matrix for purification and handling of solid reactants, which comprises at least a solid polymer carrier coated with at least one hydrosoluble polymer, and production methods. The solid carrier may be, inter alia, cross-linked polyurethane foam or a micropipette tip. The hydrosoluble polymer may be, inter alia, polyvinylalcohol, agarose, hydroxyethylcellulose or combinations thereof. The matrix may further comprise a polymer produced from glycidyl metacrylate (GMA), dimethyl acrylamide (DMAAm), 2-hydroxyethyl metacrylate, metacrylic acid, or combinations thereof.

Classes IPC  ?

• B01J 20/32 - Imprégnation ou revêtement
• B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques
• C07H 1/06 - SéparationPurification

Abrégé

The invention relates to the identification of Secreted Protein, Acidic and Rich in Cysteine (SPARC) as a new therapeutic target in patients with fulminant hepatitis and allows the development of a strategy destined to protect the liver form damage. The invention relates to the treatment of acute liver failure or fulminant hepatitis by administering to a subject in need thereof an agent that inhibits at least partially the expression of SPARC and/or interferes with its biological function.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• C07K 14/78 - Peptides du tissu connectif, p. ex. collagène, élastine, laminine, fibronectine, vitronectine ou globuline insoluble à froid [CIG]
• C07K 16/18 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains
• C12N 15/86 - Vecteurs viraux

Abrégé

The invention relates to a process for the production of propylene glycol from glycerol, comprising a Cu and Ce catalyst having concentrations of up to 15% of each metal. The invention also relates to a Cu and Ce catalyst used to perform the selective reduction of the glycerol and to the method for the production of said catalyst.

Classes IPC  ?

• B01J 37/02 - Imprégnation, revêtement ou précipitation
• B01J 23/83 - Catalyseurs contenant des métaux, oxydes ou hydroxydes métalliques non prévus dans le groupe du cuivre ou des métaux du groupe du fer en combinaison avec des métaux, oxydes ou hydroxydes prévus dans les groupes avec des terres rares ou des actinides
• C07C 29/60 - Préparation de composés comportant des groupes hydroxyle ou O-métal liés à un atome de carbone ne faisant pas partie d'un cycle aromatique à six chaînons par élimination de groupes hydroxyle, p. ex. par déshydratation

Abrégé

The invention relates to a process for the purification of crude biodiesel obtained by reacting triacylglycerol with an alcohol in the presence of a catalyst, comprising a series of water-washing operations in order to reduce the total amount of contaminants and, in particular, sterol glucosides and monoacylglycerides. The invention is characterised by the addition of water to the system before the glycerol phase is separated from the biodiesel phase.

Classes IPC  ?

• C07C 67/58 - SéparationPurificationStabilisationEmploi d'additifs par traitement liquide-liquide
• C10L 1/02 - Combustibles carbonés liquides à base essentielle de composants formés uniquement de carbone, d'hydrogène et d'oxygène
• C11C 1/02 - Préparation des acides gras à partir de graisses, huiles ou ciresRaffinage des acides gras à partir de graisses ou huiles
• C11C 1/08 - Raffinage
• C11C 3/00 - Graisses, huiles ou acides gras obtenus par transformation chimique des graisses, huiles ou acides gras, p. ex. ozonolyse

Abrégé

A process for obtaining vegetable oil rich in 1,3- diacylglycerols with at least 10% by weight of 1,3- diacylglycerols comprising a transesterification reaction of triacylglycerol and glycerin in the presence of a solid catalyst is provided. A vegetable oil rich in 1,3- diacylglycerols containing 20 to 40% by weight of 1,3- diacylglycerols is also provided.

Classes IPC  ?

• C11C 3/06 - Graisses, huiles ou acides gras obtenus par transformation chimique des graisses, huiles ou acides gras, p. ex. ozonolyse par estérification des graisses ou des huiles avec la glycérine
• C12P 7/64 - GraissesHuilesCires de type esterAcides gras supérieurs, c.-à-d. ayant une chaîne continue d'au moins sept atomes de carbone liée à un groupe carboxyleHuiles ou graisses oxydées

Abrégé

The invention relates to a process for the industrial production of lipids from organic residues, comprising cultivating strains of the Rhodococcus genus, using organic residues as sources of nutrients. Preferably, the process of the invention is carried out at a pH of between 5 and 11 and at a temperature of between 20 and 30°C, and the Rhodococcus genus strains are selected from those belonging to the following species: R. fascians, R. erythropolis, R. wratislaviensis, R. opacus and R. jostii.

Classes IPC  ?

• C12P 7/64 - GraissesHuilesCires de type esterAcides gras supérieurs, c.-à-d. ayant une chaîne continue d'au moins sept atomes de carbone liée à un groupe carboxyleHuiles ou graisses oxydées

Abrégé

A fruit harvesting device, of those that generate pulses of air and cause the detachment of said fruits by breaking their stems is provided, comprising at least two rotating elements: a first rotating element that generates a stream of air and a second rotating element that generates said pulses of air, contained in a housing, wherein said housing comprises an air entry sector, wherein said first rotating element is located, which is tapered at a taper angle of between 10° and 25°; and a control system of the frequency of said pulses of air. In preferred embodiments, said second rotating element has openings of varying size; said housing further comprises a suction lip which decreases the vena contracta effect; and pivoting means which give the device movement relative to a vertical axis and relative to a horizontal axis.

Classes IPC  ?

• A01D 46/00 - Cueillette de fruits, légumes, houblon ou de produits similairesDispositifs pour secouer les arbres ou les arbustes

Abrégé

B. parapertussis. The vaccine can comprise adjuvants, for example, aluminum hydroxide and other immunogens such as tetanus toxoid, diphtheria toxoid, or combinations thereof. B. parapertussis. The adjuvant can be aluminum hydroxide and other immunogens such as tetanus toxoid, diphtheria toxoid, or combinations thereof. The Tdap vaccine exhibits cross activity.

Classes IPC  ?

• A61K 39/10 - BrucellaBordetella, p. ex. Bordetella pertussis
• A61K 39/02 - Antigènes bactériens
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps

Abrégé

A molecular sensing method based on luminescence modulation by specific nanoparticle heating, wherein the method comprises the use of specific nanoparticle heating mechanisms to distinguish specific contributions from background contributions. This new mechanism allows obtaining sub-nanomolar sensitivity when detecting analytes in a homogeneous system (1 phase) or in an inhomogeneous system (several phases or including segregation steps before measurement). The sensing and quantification mechanism can be applied to the detection of any molecule of interest (for example, protein) having at least one recognition entity (for example antibody). This mechanism for detecting the presence of and/or for quantifying the concentration of proteins or metabolites in solution is applicable to any clinical diagnostic analysis, as well as to other non-medical quantitative analysis.

Classes IPC  ?

• G01N 21/64 - FluorescencePhosphorescence
• G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
• G01N 21/17 - Systèmes dans lesquels la lumière incidente est modifiée suivant les propriétés du matériau examiné

Abrégé

The invention relates to a method for monitoring, quantifying and evaluating grazing and rumination activities of ruminants on the basis of the detection and quantification of mastication periods, and to a device for implementing said method.

Classes IPC  ?

• A01K 29/00 - Autres appareils pour l'élevage

Abrégé

A small integrated electronic module (IEM) for polarization and pulse processing of neutron and radiation detectors, wherein the module comprises at least one high voltage submodule, an analog pulse processing submodule, a supply submodule and a control submodule. The integrated electronic module offers a basic design which can be fitted according to the user's or application's needs. This flexibility to meet different uses and users includes the use of high voltage supplies with different maximum values, which can reach + 3kV, supply voltage values, and/or for field applications, a redesign of the geometry and/or connectors. The device prototype is manufactured with aluminum and electronics are on a parallelepiped of 11 cm x 9 cm x 4 cm and 360 grams.

Classes IPC  ?

• G01T 1/17 - Dispositions de circuits non adaptés à un type particulier de détecteur
• G01T 3/00 - Mesure de flux de neutrons

Abrégé

Process for obtaining lithium compounds and intermediate compounds, comprising the following steps: a) contacting aluminosilicate particles, for example α- spodumene, with at least one fluorine compound, for example HF, Na F or others; b) stirring the mixture increasing the temperature until reaching an appropriate temperature; c) carrying out at least a precipitation and filtration process of the mixture of step b), and, d) recovering the lithium compound. The process may comprise using HF at a concentration between 5 and 30% v/v or Na F at a concentration between 5 and 30% w/v; a solid/liquid ratio of step a) between 0.9 and 14.4% w/v; a particle size of between 29 and 200 µm. The final lithium product of the process may be lithium carbonate or lithium fluoride.

Classes IPC  ?

• C22B 3/00 - Extraction de composés métalliques par voie humide à partir de minerais ou de concentrés
• C22B 3/06 - Extraction de composés métalliques par voie humide à partir de minerais ou de concentrés par lixiviation dans des solutions inorganiques acides
• C22B 3/10 - Acide chlorhydrique

Abrégé

An isoform of the TGF beta receptor II comprising a sequence of about of 80 amino acids and lacking a transmembrane domain; wherein the isoform is a TGFp-1 agonist. The isoform comprises the amino acid sequence set forth in SEQ ID No. 12. The isoform may have the amino acid sequence set forth in SEQ ID No. 2 or sequences having at least 85 % sequence identity to the sequence set forth in SEQ ID No. 2.

Classes IPC  ?

• A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
• C07K 14/71 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire pour des facteurs de croissanceRécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire pour des régulateurs de croissance
• C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales

Abrégé

A method for modulating angiogenesis in a cancer or tumor refractory to anti-VEGF, including identifying a cancer cell as being referactory to anti-VEGF, and then contacting the cancer cell refractory to anti-VEGF with an effective amount of an agent that modulates interaction between Gal1 or a Gal1 fragment and the natural binding partner of Gal1 or the Gal1 fragment to thereby modulate angiogenesis.

Classes IPC  ?

• A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
• A61P 35/00 - Agents anticancéreux
• C07K 16/18 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains

Abrégé

The present invention provides aptamers against the Myelin Basic Protein (MBP), as well as the application thereof as neuroprotective agents in Multiple Sclerosis patients and as MBP detection agents.

Classes IPC  ?

• C12N 15/115 - Aptamères, c.-à-d. acides nucléiques liant spécifiquement une molécule cible avec une haute affinité sans s'y hybrider
• A61K 31/7088 - Composés ayant au moins trois nucléosides ou nucléotides
• C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques

Abrégé

A method of treating a solid tumor in a mammal by inhibiting angiogenesis, including administering to the mammal which has a solid tumor selected from the group consisting of breast carcinoma, lung carcinoma, prostate carcinoma, colon carcinoma, ovarian carcinoma, neuroblastoma, central nervous system tumor, multiform glioblastoma and melanoma; a composition including brassinosteroids of general formula (I) can be a single or double bond and the configurations of carbon atoms C22 and C23 respectively linked to the substituents HO are S for both carbon atoms and a pharmaceutically acceptable additive.

Classes IPC  ?

• A61K 31/575 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne d'au moins trois atomes de carbone, p. ex. cholane, cholestane, ergostérol, sitostérol
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
• C07J 9/00 - Stéroïdes normaux contenant du carbone, de l'hydrogène, un halogène ou de l'oxygène, substitués en position 17bèta par une chaîne de plus de deux atomes de carbone, p. ex. cholane, cholestane, coprostane

Abrégé

The present application is directed to compositions and methods for treating a subject with cancer and/or increasing migration of a mesenchymal stromal cells (MSCs) stimulated with a recombinant autocrine motility factor (rAMF) to a tumor or a tumor cell, e.g. hepatocellular carcinoma (HCC). In addition, methods for increasing adhesion of MSCs to endothelial cells with rAMF are disclosed. In some embodiments, the MSCs comprise a therapeutic agent, e.g., an anti-tumor agent.

Classes IPC  ?

• G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer

Abrégé

An automated optomechanical platform for molecular detection by surface plasmon resonance allows working with the particular conditions necessary to excite the plasmon resonance. This makes it possible to optimize parameters to maximize sensitivity and improve detection of different analytes immersed in different matrices. For example, the detection of chemicals in water requires a different equipment configuration than that necessary for toxin detection in bovine milk. The platform comprises a light source, opticfal fibers, a pair of goniometers, a sensor,and an automated microfluidic device.

Classes IPC  ?

• G01N 21/55 - Réflexion spéculaire
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes

Abrégé

The invention relates to the identification of Secreted Protein, Acidic and Rich in Cysteine (SPARC) as a new therapeutic target in patients with fulminant hepatitis and allows the development of a strategy destined to protect the liver form damage. The invention relates to the treatment of acute liver failure or fulminant hepatitis by administering to a subject in need thereof an agent that inhibits at least partially the expression of SPARC and/or interferes with its biological function.

Classes IPC  ?

• C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• C07K 16/18 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains

Abrégé

A biocidal compound characterized in that it comprises the following molecule (Figure 2): wherein: R1 is selected from the group comprised of methyl and propylene, and R2 is selected from the group comprised of C12H25, C15H25 and C11F17H6 A process for making it, and a wood preservative composition comprising it.

Classes IPC  ?

• A01N 33/12 - Composés d'ammonium quaternaire
• C07C 211/63 - Composés d'ammonium quaternaire ayant des atomes d'azote quaternisés liés à des atomes de carbone acycliques

Abrégé

A vaccine for the prevention of infections with Bordetella, comprising at least outer membrane vesicles (OMVs) of B. parapertussis, excipients and/or adjuvants. Bordetella may be, for example, B. pertussis or B. parapertussis. The vaccine can comprise adjuvants, for example, aluminum hydroxide and other immunogens such as tetanus toxoid, diphtheria toxoid, or combinations thereof. In another preferred embodiment, the vaccine for the prevention of infections with Bordetella comprises at least outer membrane vesicles (OMVs) of B. pertussis and the lipopolysaccharide of B. parapertussis, excipients and/or adjuvants. The vaccine can comprise between 3 to 20 μg per dose of OMVs from B. pertussis and between the amount equivalent to 107 and 1010 bacteria per dose of lipopolysaccharide of B. parapertussis. The adjuvant can be aluminum hydroxide and other immunogens such as tetanus toxoid, diphtheria toxoid, or combinations thereof. The Tdap vaccine exhibits cross activity.

Classes IPC  ?

• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps

Abrégé

The present disclosure provides engineered microorganisms, engineered biosynthetic pathways, methods of producing lipid compounds using genetically engineered microorganisms, and the products synthesized by those organisms. In particular, the disclosure provides genetically engineered microorganisms for the production of multi-methyl branched fatty acids (MMBFAs) and MMBFA esters (wax esters) derived from these fatty acids. In addition, the disclosure provides methods for producing acylglycerols with one of more of their acyl substituents being an MMBFA, and methods for producing alcohols derived from MMBFAs (fatty alcohols).

Classes IPC  ?

• C12P 7/64 - GraissesHuilesCires de type esterAcides gras supérieurs, c.-à-d. ayant une chaîne continue d'au moins sept atomes de carbone liée à un groupe carboxyleHuiles ou graisses oxydées
• C12N 1/00 - Micro-organismes, p. ex. protozoairesCompositions les contenantProcédés de culture ou de conservation de micro-organismes, ou de compositions les contenantProcédés de préparation ou d'isolement d'une composition contenant un micro-organismeLeurs milieux de culture
• C12N 1/20 - BactériesLeurs milieux de culture

Abrégé

Mutated polypeptide, strains comprising it and methods to detect metallic cations, for example Au, Cu, Ag, Hg, Pb, Cd, Co and Zn, in samples simultaneously, wherein the polypeptide comprises a substitution of serine with cysteine in position 77 of SEQ ID NO: 1 or SEQ ID NO: 2; and wherein said protein has activity of transcriptional regulator, for example GolS or CueR. The polypeptide detects the metals as monovalent and divalent metallic cations.

Classes IPC  ?

• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
• C07K 14/255 - Salmonella (G)
• C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
• C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN

Abrégé

The present invention provides isolated LNK polypeptides and nucleic acids encoding the same. Also provided are methods of introducing a nucleic acid encoding LNK polypeptides and/or LNK antagonists into a plant cell, plant part or plant, e.g., to increase tolerance to abiotic stress, to delay development and/or prolong the life span of a plant, and/or to increase yield from the plant. Also provided are transformed plants, plant tissues, plant cells and plant seed comprising the nucleic acids, expression cassettes and vectors of the invention.

Classes IPC  ?

• C12P 21/06 - Préparation de peptides ou de protéines préparés par hydrolyse d'une liaison peptidique, p. ex. hydrolysats

Abrégé

Antimicrobial peptides such as, for example, the peptides shown in SEQ ID N° 1, SEQ ID N° 2, SEQ ID N° 3, SEQ ID N° 4 or SEQ ID N° 5. The peptides have activity against Gram positive bacteria and against Gram negative bacteria. A bactericidal composition is also provided, which may comprise an amount between 0.5 μg/mL and 1024 μg/mL of the peptides; and excipients.

Classes IPC  ?

• A61P 31/00 - Agents anti-infectieux, c.-à-d. antibiotiques, antiseptiques, chimiothérapeutiques
• A61K 38/00 - Préparations médicinales contenant des peptides

Abrégé

An efficient and low environmental impact method is disclosed for the recovery of lithium from aqueous solution, for example., brines from high altitude salt lakes. The method comprises the use of an electrochemical reactor with electrodes which are highly selective for lithium, where lithium ions are inserted in the crystal structure of manganese oxide in the cathode, and extracted from the crystal structure of manganese oxide in the anode. Also disclosed are three-dimensional carbon electrodes embedded in manganese oxides formed by impregnating a porous support, for example a carbon felt, with a manganese oxide/carbon black slurry.

Classes IPC  ?

• B01J 47/02 - Procédés sur colonne ou sur lit
• B01J 47/06 - Procédés sur colonne ou sur lit durant lesquels la substance échangeur d'ions est soumise à un traitement physique, p. ex. à la chaleur, à un courant électrique, à une irradiation ou à une vibration
• C01D 15/00 - Composés du lithium

Abrégé

Lysozyme amyloid fibers, wherein the lysozyme is self-assembled forming fibrous complexes (biological nanotubes) which secondary structure comprises at least one cross-beta structure, since the native lysozyme lacks said structures. The lysozyme amyloid fibers lack biological and enzymatic activity. The support for protein binding comprises lysozyme amyloid fibers, and the biocatalyst comprises at least one enzyme bound to the lysozyme amyloid fibers support by a photosensitizing method. The immobilized protein can be an enzyme, for example a lipase. The process significantly increases enzymatic stability of the immobilized biological product.

Classes IPC  ?

• C12N 11/10 - Enzymes ou cellules microbiennes immobilisées sur ou dans un support organique le support étant un hydrate de carbone

Abrégé

A process for obtaining turbo biofuel from castor oil wherein the oil, methanol and sodium hydroxide previously diluted in said methanol, are reacted by transesterification at a temperature less than 40°C and for a maximum time of 60 minutes; it is decanted; formed glycerin, is removed; it is neutralized with acid; it is washed with water in at least two steps; the aqueous phase from the last washing is removed to obtain raw biodiesel; the remaining water and methanol are eliminated by vacuum distillation and raw, dry biodiesel is obtained, which is diluted with JP A1 turbo fuel at a concentration of biodiesel of between 5 and 30% w/w, a 50% mixture of C1-C3 light alcohol with water is added; this mixture is kept at -29°C for 12 hours; it is centrifuged; it is filtered through a filter of 20 microns; it is filtered through a filter of 1 micron.

Classes IPC  ?

• C10L 1/04 - Combustibles carbonés liquides à base essentielle de mélanges d'hydrocarbures
• C10L 1/10 - Combustibles carbonés liquides contenant des additifs
• C10L 1/18 - Composés organiques contenant de l'oxygène

Abrégé

The present invention provides isolated HaHB11 polypeptides and nucleic acids encoding the same. Also provided are methods of introducing a nucleic acid encoding HaHB11 polypeptides into a plant cell, plant part or plant, e.g., to increase tolerance to abiotic stress, to delay development and/or prolong the life span of a plant, and/or to increase yield from the plant. The invention also provides nucleic acids comprising HaHB11 promoter sequences and methods for expressing a nucleotide sequence of interest operab.lv associated vvith the HaHB11 promoters of the invention in a plant cell, plant part, or plant. Also provided are transformed plants, plant tissues, plant cells and plant seed comprising the nucleic acids, expression cassettes and vectors of the invention.

Classes IPC  ?

• C12N 15/82 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules végétales
• A01H 5/00 - Angiospermes, c.-à-d. plantes à fleurs, caractérisées par leurs parties végétalesAngiospermes caractérisées autrement que par leur taxonomie botanique
• C12N 5/04 - Cellules ou tissus végétaux
• C12N 15/00 - Techniques de mutation ou génie génétiqueADN ou ARN concernant le génie génétique, vecteurs, p. ex. plasmides, ou leur isolement, leur préparation ou leur purificationUtilisation d'hôtes pour ceux-ci

Abrégé

The present invention provides isolated HaHB11 polypeptides and nucleic acids encoding the same. Also provided are methods of introducing a nucleic acid encoding HaHB11 polypeptides into a plant cell, plant part or plant, e.g., to increase tolerance to abiotic stress, to delay development and/or prolong the life span of a plant, and/or to increase yield from the plant. The invention also provides nucleic acids comprising HaHB11 promoter sequences and methods for expressing a nucleotide sequence of interest operab.lv associated vvith the HaHB11 promoters of the invention in a plant cell, plant part, or plant. Also provided are transformed plants, plant tissues, plant cells and plant seed comprising the nucleic acids, expression cassettes and vectors of the invention.

Classes IPC  ?

• A01H 5/00 - Angiospermes, c.-à-d. plantes à fleurs, caractérisées par leurs parties végétalesAngiospermes caractérisées autrement que par leur taxonomie botanique
• A01H 5/10 - Graines
• C07K 14/415 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de végétaux
• C12N 5/10 - Cellules modifiées par l'introduction de matériel génétique étranger, p. ex. cellules transformées par des virus
• C12N 15/29 - Gènes codant pour des protéines végétales, p. ex. thaumatine
• C12N 15/82 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules végétales

Abrégé

A method of treating a solid tumor in a mammal by inhibiting angiogenesis, comprising administering to the mammal which has a solid tumor selected from the group consisting of breast carcinoma, lung carcinoma, prostate carcinoma, colon carcinoma, ovarian carcinoma, neuroblastoma, central nervous system tumor, multiform glioblastoma and melanoma; a composition comprising brassinosteroids of general formula (I), wherein (I) can be a single or double bond and the configurations of carbon atoms C22 and C23 respectively linked to the substituents HO are S for both carbon atoms and a pharmaceutically acceptable additive.

Classes IPC  ?

• A61K 31/575 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne d'au moins trois atomes de carbone, p. ex. cholane, cholestane, ergostérol, sitostérol
• A61P 35/00 - Agents anticancéreux

Abrégé

The present invention relates to novel fusion proteins. More specifically, the present invention relates to a fusion protein comprising proinsulin fused via a peptide bond to thioredoxin, useful in the detection of anti-proinsulin (PAA) and/or anti-insulin (IAA). The present invention also relates to a method for producing the fusion protein, to DNA sequences encoding the fusion protein of Thioredoxin-Proinsulin, to expression vectors containing such DNA sequences, to cells transformed with said expression vector, to a process for producing proinsulin, to a process for producing insulin, and to methods for detecting and characterizing anti-proinsulin autoantibodies (PAA) and/or anti-insulin autoantibodies (IAA).

Classes IPC  ?

• C07K 14/62 - Insulines
• C12N 15/62 - Séquences d'ADN codant pour des protéines de fusion
• G01N 33/564 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour complexes immunologiques préexistants ou maladies auto-immunes

Abrégé

Recombinant bacterial strains comprising heterologous nif genes in its genome, and capable of fixing nitrogen. The strain may be, for example, a recombinant Pseudomonas fluorescens strain comprising heterologous nif genes in its genome. An inoculum and a method for increasing plant productivity are further described.

Classes IPC  ?

• C12N 1/21 - BactériesLeurs milieux de culture modifiés par l'introduction de matériel génétique étranger
• C12N 9/02 - Oxydoréductases (1.), p. ex. luciférase
• C07K 14/21 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries provenant de Pseudomonadaceae (F)
• A01N 63/00 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des micro-organismes, des virus, des champignons microscopiques, des animaux ou des substances produites par, ou obtenues à partir de micro-organismes, de virus, de champignons microscopiques ou d'animaux, p. ex. enzymes ou produits de fermentation
• C12R 1/39 - Pseudomonas fluorescens

Abrégé

The present invention relates to prevention or treatment of diseases related to abnormal cell proliferation, such as cancer, by administering meta- or orto-tyorosine to a subject in need thereof, for instance a human subject. More specifically, the present invention provides isomers of tyrosine for its use in the prevention or treatment of a disease and in the preparation of pharmaceutical compositions, methods of for treating or preventing diseases, such as cancer and cancer metastases, and pharmaceutical compositions containing meta- and/or orto-tyorosine.

Classes IPC  ?

• A61K 31/198 - Alpha-amino-acides, p. ex. alanine ou acide édétique [EDTA]
• A61P 35/00 - Agents anticancéreux
• A61P 35/04 - Agents anticancéreux spécifiques pour le traitement des métastases

Abrégé

Low-cost and easily-operated microviscometer suitable for medical diagnosis clinical studies and other fluid tests. The equipment consists of a microchannel (2) formed by concatenated microchannels made by micro-manufacturing techniques, and a fluid column position detector inside the microchannel. The microchannels are open at one end and closed at the other end and are made of a single biocompatible material. When a liquid drop is put into the inlet of the microchannel (2), the fluid enters by capillary until the compressed air pressure equals the capillary pressure plus atmospheric pressure. The fluid transient movement from entering the channel until stopping at its balance position is analyzed thus obtaining as a result the viscosity and the capillary pressure of the liquid tested.

Classes IPC  ?

• G01N 11/04 - Recherche des propriétés d'écoulement des matériaux, p. ex. la viscosité, la plasticitéAnalyse des matériaux en déterminant les propriétés d'écoulement en mesurant l'écoulement du matériau à travers un passage étroit, p. ex. un tube, une ouverture

Abrégé

A formulation that promotes targeted pollination of melliferous bees to sunflower crops that comprises Sabinene, beta-Pinene and Limonene. The formulation can be administered dissolved in a sweetened solution.

Classes IPC  ?

• A01N 27/00 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des hydrocarbures
• A23K 1/18 - spécialement conçus pour des animaux déterminés
• A23K 1/16 - additionnés d'éléments nutritifs accessoires; Blocs de sel
• A01K 47/06 - Autres détails des ruches, p. ex. dispositifs d'aération, entrées de ruches, dispositifs de sûreté, séparations ou issues pour les abeilles

Abrégé

A formulation that promotes targeted pollination of melliferous bees to apple crops that comprises Citral, Benzaldehyde and Limonene. The formulation can be administered dissolved in a sweetened solution.

Classes IPC  ?

• A01N 27/00 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des hydrocarbures
• A01N 35/02 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques comportant un atome de carbone possédant deux liaisons à des hétéro-atomes, avec au plus une liaison à un halogène, p. ex. un radical aldéhyde contenant des groupes aldéhyde ou cétone, ou leurs thio-analogues, liés aliphatiquementLeurs dérivés, p. ex. acétals
• A01N 35/04 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques comportant un atome de carbone possédant deux liaisons à des hétéro-atomes, avec au plus une liaison à un halogène, p. ex. un radical aldéhyde contenant des groupes aldéhyde ou cétone, ou leurs thio-analogues, liés directement à un système cyclique aromatique, p. ex. acétophénoneLeurs dérivés, p. ex. acétals
• A23K 1/18 - spécialement conçus pour des animaux déterminés
• A23K 1/16 - additionnés d'éléments nutritifs accessoires; Blocs de sel
• A01K 47/06 - Autres détails des ruches, p. ex. dispositifs d'aération, entrées de ruches, dispositifs de sûreté, séparations ou issues pour les abeilles

Abrégé

Brucella genus. The adjuvant may be a modified polypeptide or may be, for example, the Omp19S polypeptide or the Omp16S polypeptide, parts or mixtures of the two. In a preferred embodiment, the adjuvant is the non-lipidated polypeptide included in SEQ ID No: 1, or parts thereof. In a further preferred embodiment, the adjuvant is the non-lipidated polypeptide included in SEQ ID No: 2 or parts thereof.

Classes IPC  ?

• A61K 39/39 - Préparations médicinales contenant des antigènes ou des anticorps caractérisées par les additifs immunostimulants, p. ex. par les adjuvants chimiques
• C12N 5/10 - Cellules modifiées par l'introduction de matériel génétique étranger, p. ex. cellules transformées par des virus
• C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales
• C07K 14/23 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries provenant de Brucella (G)
• A61P 37/04 - Immunostimulants
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps

Abrégé

A biodegradable, biocompatible and non-toxic material is disclosed, which may be used to isolate and/or to protect a product from the environment, wherein said material comprises a matrix composed by starch, glycerol and starch nano-crystals dispersed in said matrix. The material may be used in the form of foils, sheets, films, coatings, gels, etc, to isolate and/or to protect a product from the environment. The material may be used to isolate and or to protect food, pharmaceutical, cosmetic and cleaning products.

Classes IPC  ?

• C08L 3/00 - Compositions contenant de l'amidon, de l'amylose ou de l'amylopectine ou leurs dérivés ou leurs produits de dégradation
• C08J 5/18 - Fabrication de bandes ou de feuilles
• C08L 3/02 - AmidonSes produits de dégradation, p. ex. dextrine
• A23L 1/00 - Aliments ou produits alimentaires; Leur préparation ou traitement (leur conservation en général A23L 3/00)
• C08K 5/053 - Alcools polyhydroxyliques
• C08K 5/00 - Emploi d'ingrédients organiques

Abrégé

Vaccine against neoplastic or cancerous lesions caused by human papillomavirus (HPV), which comprises E7 peptide spherical particles and, as an option, an adjuvant, where spherical particles may be oligomeric. The oligomeric spherical particles may have a diameter in the vicinity of 50 nm and a molecular weight in the vicinity of 700 kDa. The vaccine may be helpful to prevent or treat human papillomavirus (HPV)-related lesions or do both things at the same time.

Classes IPC  ?

• A61K 39/39 - Préparations médicinales contenant des antigènes ou des anticorps caractérisées par les additifs immunostimulants, p. ex. par les adjuvants chimiques
• A61K 31/675 - Composés du phosphore ayant l'azote comme hétéro-atome d'un cycle, p. ex. phosphate de pyridoxal
• A61K 31/445 - Pipéridines non condensées, p. ex. pipérocaïne
• A61K 31/721 - Dextranes
• A61P 35/00 - Agents anticancéreux

Abrégé

Adjuvant for vaccines that comprises a non-lipidated bacterial outer-membrane polypeptide (Omp), in which the bacteria may be those of the Brucella genus. The adjuvant may be a modified polypeptide or may, for example, be the Omp19S or Omp16S polypeptide, parts thereof or mixtures of the two. In a preferred embodiment, the adjuvant is the non-lipidated polypeptide included in SEQ ID No: 1, or parts thereof. In a further preferred embodiment, the adjuvant is the non-lipidated polypeptide included in SEQ ID No: 2, or parts thereof.

Classes IPC  ?

• A61K 38/00 - Préparations médicinales contenant des peptides
• A61K 39/10 - BrucellaBordetella, p. ex. Bordetella pertussis
• A61K 39/39 - Préparations médicinales contenant des antigènes ou des anticorps caractérisées par les additifs immunostimulants, p. ex. par les adjuvants chimiques
• A61P 31/04 - Agents antibactériens
• C07K 14/23 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries provenant de Brucella (G)
• C12N 5/12 - Cellules fusionnées, p. ex. hybridomes
• C12N 15/01 - Préparation de mutants sans introduction de matériel génétique étrangerProcédés de criblage à cet effet

Abrégé

Adjuvant for vaccines that comprises a non-lipidated bacterial outer-membrane polypeptide (Omp), in which the bacteria may be those of the Brucella genus. The adjuvant may be a modified polypeptide or may, for example, be the Omp19S or Omp16S polypeptide, parts thereof or mixtures of the two. In a preferred embodiment, the adjuvant is the non-lipidated polypeptide included in SEQ ID No: 1, or parts thereof. In a further preferred embodiment, the adjuvant is the non-lipidated polypeptide included in SEQ ID No: 2, or parts thereof.

Classes IPC  ?

• A61K 39/10 - BrucellaBordetella, p. ex. Bordetella pertussis
• A61K 38/00 - Préparations médicinales contenant des peptides
• A61K 39/39 - Préparations médicinales contenant des antigènes ou des anticorps caractérisées par les additifs immunostimulants, p. ex. par les adjuvants chimiques
• C07K 14/23 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries provenant de Brucella (G)
• C12N 15/01 - Préparation de mutants sans introduction de matériel génétique étrangerProcédés de criblage à cet effet
• C12N 5/12 - Cellules fusionnées, p. ex. hybridomes
• C12N 1/20 - BactériesLeurs milieux de culture
• A61P 31/04 - Agents antibactériens

Abrégé

A device for diagnosis of physiologic status and/or selection of best spermatozoa of a semen sample based on chemotaxis, and the procedure of thereof, enabling by a simple and inexpensive device the diagnosis and selection of the best spermatozoa in only one step. Only needed are: the present device, a regular light microscope, and personnel with elementary knowledge of laboratory management. The device is of the type having two communicated compartments (1a, 1b), and where said compartments (1a, 1b) communication occurs through a duct or bridge (2) located in the lower part, and above the lower level of mentioned compartments (1a, 1b); in the entrances of said compartments (1a, 1b) appropriate closing means (3, 4) and appropriate air output ducts (5) are placed communicating the top end of compartments (1a, 1b) with the exterior.

Classes IPC  ?

• C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
• C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet

Abrégé

Brassinosteriods, illustrated by the following exemplary compounds, are disclosed: The compounds have anti-inflammatory and antiviral activity. In pharmaceutical compositions, the compounds are useful in ophthalmic pharmaceuticals for treatment of diseases caused by adenovirus, such as epidemic keratoconjunctivitis, and herpes simplex type 1, such as herpetic stromal keratitis.

Classes IPC  ?

• A61K 31/575 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne d'au moins trois atomes de carbone, p. ex. cholane, cholestane, ergostérol, sitostérol
• C07J 9/00 - Stéroïdes normaux contenant du carbone, de l'hydrogène, un halogène ou de l'oxygène, substitués en position 17bèta par une chaîne de plus de deux atomes de carbone, p. ex. cholane, cholestane, coprostane

Abrégé

Procedure and device to estimate organoleptic parameters of tissues of animal origin, i.e. meat allowing to measure toughness, tenderness, or muscle tone for situations where qualification is required. It is based on the measurement of dielectric permittivity in a frequency spectrum and in computing muscle bidirectional electrical anisotropy index (BEAI). The device has a specially designed cell where the muscle sample (2, 7) is placed and is put in contact with the metallic electrodes (8) forming an impedance measurement system (4-6; 9-12) in the frequency range of 0.1 Hz to 10 MHz, and the permittivity (ε) value is thus calculated along with the bidirectional electrical anisotropy index. The bidirectional electrical anisotropy index is displayed or communicated to a PC (11) for monitoring and telemetry functions. The advantage of this device over the alternatives suggested in the literature is the insensibility to muscle conductivity changes. The bidirectional electrical anisotropy index then correlates with organoleptic tenderness, as determined by a sensorial evaluation panel.

Classes IPC  ?

• G01N 33/12 - Viande Poisson
• G01N 27/02 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance
• G01N 27/22 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance en recherchant la capacité

Abrégé

A method for the identification of genes involved in neurodegenerative processes, detectable by the late onset of a phenotype associated with neurodegeneration, by means of a genetic screen of deregulated genes, which comprises the measurement of sleep-wake cycle activity schemes in different stages of life, young and adult, of individuals of an animal model, such as Drosophila. A mutant fly whose genome comprises a disruption in its enabled gene, with decrease of the enabled gene expression, and exhibiting a late onset neurodegenerative phenotype in adulthood.

Classes IPC  ?

• C12N 15/12 - Gènes codant pour des protéines animales
• C12N 15/00 - Techniques de mutation ou génie génétiqueADN ou ARN concernant le génie génétique, vecteurs, p. ex. plasmides, ou leur isolement, leur préparation ou leur purificationUtilisation d'hôtes pour ceux-ci
• C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques

Abrégé

A microapparatus (11) implantable in the eye (13) includes a cuasi-bistable microvalve (21) commanded by an intraocular pressure sensor (23) in situ. The microvalve mechanism includes a diaphragm (27) made of a conjugated polymer (29) that shows high deformation and biocompatibility capabilities and which volume depends from the electric potential applied by its pair of electrodes (31). The sensor and actuator-valve are coupled to a drainage conduit (15), the first to deform by the pressure in the ocular globe and the second in a position of buckling to normally close the drainage conduit. The sensor has a membrane of conductive polymeric material with these same properties and whose ohmic resistance varies with the mechanical deformation produced by the ocular pressure.

Classes IPC  ?

• A61F 2/14 - Parties d'yeux, p. ex. cristallins ou implants de cornéeYeux artificiels
• A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras

Abrégé

Transglutaminases binding fusion protein, compositions comprising thereof, micro-spheres comprising thereof, uses and methods. The fusion protein might comprise a transglutaminases binding domain, for example the cementoin domain and a serine proteases inhibitor, for example the secretory leucocitary proteases inhibitor (SLPI). The fusion proteins are useful for the preparation of medicaments for the treatment of, for example, autoimmune diseases, inflammatory disorders, cancer, infections and healing of wounds.

Classes IPC  ?

• C07K 14/81 - Inhibiteurs de protéase
• A61K 47/48 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. supports, additifs inertes l'ingrédient non actif étant chimiquement lié à l'ingrédient actif, p.ex. conjugués polymère-médicament

Abrégé

A process for preparing attenuated viral strains, comprising to contact, at least one sulphated polymer and a virus susceptible to the inhibition of said polymer, via successive passages of the virus with increasing polymeric concentrations, where said amenable virus is characterized by the method of reducing viral plates and where the strain resulting from the attenuated virus has stable phenotypic and genotypic characteristics, different from that of the virus strain in wild state that generated thereto. The process comprises to contact the sulphated polymer (s) with the virus susceptible to the inhibition of said polymer via about 15 or more successive passages with increasing concentrations of said sulphated polymer (s). According to the inventive process, the concentration of said at least one sulphated polymer in the first passage should be less than the IC50 of said polymer for the amenable virus when it is found in wild state. Use of the attenuated viral strains through the above mentioned process in the preparation of vaccines and pharmaceutical compositions.

Classes IPC  ?

• C12N 7/08 - Inactivation ou atténuationProduction de parties élémentaires de virus par passages successifs de virus

Abrégé

Modified Thomsen-Friedenreich disaccharide (TFD) immunogen, preparation procedure, compositions containing it, uses, and treatment methods. More specif ically, the present invention refers to a immunogen obtained by modifying TFD, and comprising the general formula D-TFD- Lys(n)-C, wherein D is a hydrophobic terminal residue, TFD is disaccharide Galβ3GalNAcα; Lys(n) is a lysine connector, and n is an integer between 1 and 5, and C is a carrier. In a preferred embodiment, the modified invention immunogen comprises the general formula BzlαTFD-Lys5-KLHs, wherein BzI is benzyl, TFD is disaccharide Galβ3GalNAcα; Lys5 is penta-lysine, and KLHs is succinilated Keyhole limpets hemocyanin.

Classes IPC  ?

• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61K 39/385 - Haptènes ou antigènes, liés à des supports

Abrégé

A process for the production of catalysts useful for hydrocarbon decomposition comprising the stages of : a) -f orming a mixed urea solution comprising soluble salts of metal ion selected from the group consisting in: a group I transition divalent metal (Me (II) ) selected between Co, Ni, Cu, and Zn; Al (III), and Mn(II), at pH between 3 and 6, b) -ageing the mixed solution containing urea-Me(II)- magnesium ( II ) -aluminum ( III ) at a temperature between 70 and 100° C; c) - precipitating from the aged solution a double laminar hydroxide (HDL) consisting of said divalent metal (Me (II) ), magnesium, and aluminum, in order to form a catalyst precursor, d) -activating the catalyst precursor obtained in stage c) by reduction in an atmosphere containing hydrogen at atmospheric pressure, and at a temperature between 600 and 750° C. Catalysts obtained by said process, and a hydrogen and syngas production process employing said catalysts are also disclosed.

Classes IPC  ?

• B01J 23/00 - Catalyseurs contenant des métaux, oxydes ou hydroxydes métalliques non prévus dans le groupe
• B01J 23/06 - Catalyseurs contenant des métaux, oxydes ou hydroxydes métalliques non prévus dans le groupe du zinc, du cadmium ou du mercure
• B01J 23/78 - Catalyseurs contenant des métaux, oxydes ou hydroxydes métalliques non prévus dans le groupe du cuivre ou des métaux du groupe du fer en combinaison avec des métaux, oxydes ou hydroxydes prévus dans les groupes avec des métaux alcalins ou alcalino-terreux ou du béryllium
• B01J 37/03 - PrécipitationCo-précipitation
• B01J 37/18 - Réduction avec des gaz contenant de l'hydrogène libre

Abrégé

An air pulse generating fruit harvesting device that causes the oscillation and detaching of said fruits by fatigue and breakage of the stems of the same, that comprises at least two rotating elements: a first rotating element that generates an air current and a second rotating element that movably guides said pulses of air; and also comprises static blades that guide said air current. A process to harvest fruits with said device.

Classes IPC  ?

• A01D 46/00 - Cueillette de fruits, légumes, houblon ou de produits similairesDispositifs pour secouer les arbres ou les arbustes

Abrégé

The present invention refers to a compound having anti-inflammatory and antiviral activity according to the following structural formula (I): wherein, R1 and R3 are selected from H, HO-, R5-O-, HCOO-, R5- COO-, -OOC-R6-COO-, p-toluene sulphonate, phosphate, tartrate, maléate, sulphate, fluorine, chlorine, bromine, iodine and methanesulphonate, R2 is selected from H, HO-, R5-O-, HCOO-, R5-COO-, -OOC- R6-COO-, p-toluene sulphonate, phosphate, tartrate, maléate, sulphate, fluorine, chlorine, bromine and iodine, or -R1 and -R2 can be together -O-, ( CH3 ) 2- ( CO )2 - (6-- (CH3-CH2 )2-( CO)2- R4 and R5 are selected from H and linear or branched C1-C4 alkyl, R6 is -(CH2)n- wherein n equals to 1, 2 ó 3, and, formula (II) can be a single bond or double bond, to the pharmaceutical compositions comprising the same, to a process for preparing the same and to the use of the same for preparing pharmaceutical compositions. Particularly, the compounds of the invention are particularly useful for preparing ophthalmic pharmaceuticals for the treatment of diseases caused by adenovirus and preferably, epidemic keratocon junctivitis. Also, the compounds of the invention are particularly useful for preparing ophthalmic pharmaceuticals for the treatment of diseases caused by the herpes simplex type 1 (HSV-1) and preferably, herpetic stromal keratitis (HK).

Classes IPC  ?

• C07J 9/00 - Stéroïdes normaux contenant du carbone, de l'hydrogène, un halogène ou de l'oxygène, substitués en position 17bèta par une chaîne de plus de deux atomes de carbone, p. ex. cholane, cholestane, coprostane

Abrégé

The invention provides promoters inducible by reactive oxygen species (ROS), capable of driving the expression of a gene of interest, particularly in a tumor cell. More particularly, it refers to promoters inducible by reactive oxygen species, that may be used to drive the expression of a gene of interest, such as a therapeutic gene, or a reporter gene for use in image diagnosis. The promoters comprise at least a fragment of a promoter sequence responsive to said reactive oxygen species, and corresponding to a gene highly expressed in cancer cells, wherein the fragment of the promoter sequence responsive to reactive oxygen species (ROS) is selected from the group of: the VE element of the VEGF promoter, the E6 element of the promoter of the EGR-1 gene, the MMP-1 element and a chimeric promoter containing an E6 element and a VE element. It also provides vectors carrying a human therapeutic or non therapeutic gene of interest, operably linked to said promoter sequence and compositions comprising the same.

Classes IPC  ?

• C07H 21/04 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le désoxyribosyle comme radical saccharide
• C12N 15/00 - Techniques de mutation ou génie génétiqueADN ou ARN concernant le génie génétique, vecteurs, p. ex. plasmides, ou leur isolement, leur préparation ou leur purificationUtilisation d'hôtes pour ceux-ci

Abrégé

CeIl lines, compositions comprising them for the treatment of melanomas, procedures to prepare the compositions, and treatment methods. More particularly, the invention relates to diverse human melanoma cell lines for the treatment of malignant diseases, wherein the cell lines are: (a) MeI-XYl (deposited at German Collection of Microorganisms and Cell Cultures DSMZ under access number DSM ACC2830), (b) Mel-XY2 (deposited at Germán Collection of Microorganisms and Cell Cultures DSMZ under access number DSM ACC2831), (c) Mel-XY3 (deposited at Germán Collection of Microorganisms and Cell Cultures DSMZ under access number DSM ACC2832), (d) Mel-XX4 (deposited at Germán Collection of Microorganisms and Cell Cultures DSMZ under access number DSM ACC2829), or (e) sub-populations thereof. The cell lines may be irradiated, thus obtaining populations with apoptotic phenotype, and populations with necrotic phenotype of such lines. The compositions may comprise adjuvants and/or immuno-modif iers, and/or autologous dendritic cells.

Classes IPC  ?

• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61P 35/00 - Agents anticancéreux
• C12N 5/09 - Cellules tumorales

Abrégé

A method and device to decrease separation losses in a harvester, wherein grain separation losses or harvest yield are detected and controlled changes are introduced to the advance speed of the harvester in a way that can be previously defined by the producer without overriding the contribution of the operator driving the machine. Instead of connecting the accelerator cable (37) to the accelerator pedal (25), it is physically connected to an electrical motor (31). On the other hand, the pedal is connected to a positioning sensor (29) that is read by a processor (43), which delivers a control signal to the electric motor to control the fuel passage to optimize the harvester advance speed (11), seeking for the best balance between separation losses and harvest time.

Classes IPC  ?

• A01D 41/127 - Dispositions pour la commande ou la mesure spécialement adaptées aux moissonneuses-batteuses

Abrégé

CeIl lines, compositions comprising them for the treatment of melanomas, procedures to prepare the compositions, and treatment methods. More particularly, the invention relates to diverse human melanoma cell lines for the treatment of malignant diseases, wherein the cell lines are: (a) MeI-XYl (deposited at German Collection of Microorganisms and Cell Cultures DSMZ under access number DSM ACC2830), (b) Mel-XY2 (deposited at Germán Collection of Microorganisms and Cell Cultures DSMZ under access number DSM ACC2831), (c) Mel-XY3 (deposited at Germán Collection of Microorganisms and Cell Cultures DSMZ under access number DSM ACC2832), (d) Mel-XX4 (deposited at Germán Collection of Microorganisms and Cell Cultures DSMZ under access number DSM ACC2829), or (e) sub-populations thereof. The cell lines may be irradiated, thus obtaining populations with apoptotic phenotype, and populations with necrotic phenotype of such lines. The compositions may comprise adjuvants and/or immuno-modif iers, and/or autologous dendritic cells.

Classes IPC  ?

• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• C12N 5/06 -

Abrégé

A highly sensitive bolometric sensor (1) capable of being prepared with tnicro-manuf acturing techniques, wherein such sensor may be placed in a bi-dimensional array, with high degree of filling. It is constituted by at least one platform (2) to capture electromagnetic radiation, by defining a channel in the central part capable of locating inside at least two bars (4) linked to such platform by one end, and by the remaining ends to respective anchoring elements (5) to a substrate located below such platform (2). Such bars (4) possess at least one section reduction (6, I)I where preferably such section reductions (6, 7) are two on each bar, and located on the ends thereof.

Classes IPC  ?

• G01J 5/38 - Pyrométrie des radiations, p. ex. thermométrie infrarouge ou optique en utilisant l'allongement ou la dilatation de solides ou de fluides

Abrégé

The invention consists in a patent structure as a 'blanket' constituted by blocks preferably of concrete linked (in orthogonal directions) between each other through chords, wires, strings made of materials resistant to strengths, and the chemical environment wherein it is placed, all in order to resist hydraulic actions. The blocks basically constitute a body formed by two truncated-conic linked by their bases and located (bonded) one beside the other in a same plane, allowing the blanket to intimately adapt to the shape of the underlying surface. This layout allows the blankets to pile up one upon the other, since the block hemi-bodies fit in the empty spaces of the blankets. This geometrical advantage allows the distribution of hydraulic forces in the three directions of space, where de layers behave as a sole flexible structure. This latter aspect is the fundamental innovation (vertical fitting), like the block geometry, with disposition thereof upon a resistant mesh (articulations).

Classes IPC  ?

• E02B 3/12 - Revêtement de berges, barrages, lits de cours d'eau ou analogues

Abrégé

A microapparatus (11) implantable in the eye (13) comprises a cuasi-bistable microvalve (21) commanded by an intraocular pressure sensor (23) in situ. The microvalve mechanism includes a diaphragm (27) made of a conjugated polymer (29) that shows high deformation and biocompatibility capabilities and which volume depends from the electric potential applied by its pair of electrodes (31). The sensor and actuator-valve are coupled to a drainage conduit (15), the first to deform by the pressure in the ocular globe and the second in a position of buckling to normally close the drainage conduit. The sensor us a membrane of conductive polymeric material with these same properties and whose ohmic resistance varies with the mechanical deformation produced by the ocular pressure.

Classes IPC  ?

• A61F 9/007 - Procédés ou dispositifs pour la chirurgie de l'œil

Abrégé

A passive stream regulating system applicable to air-flue gas or water-flue gas heat exchangers, preferably natural gas balanced flue or natural flue home heaters and home boilers, which allows to attain non-over oxygenated stoichiometric mixture conditions. The system is comprised by small diameter tubes or other geometric systems formed by small channels, to produce a strong laminarization of the aerodynamic flow established within the venting tube, which are located in sections of the conduit or passage of incoming cold air to the combustion chamber of the exchanger or in sections of the conduit or passage of hot flue gases released to the environment.

Classes IPC  ?

• F23L 17/04 - Dispositifs d'équilibrage des conduits de circulation, c.-à-d. dispositifs qui combinent l'entrée d'air dans l'appareil de combustion avec la sortie des fumées

Abrégé

The system records the movement of tiny organisms housed in closed micro plates traversed by an infrared beam generating a signal as a function of the diffraction caused by the body of the microorganism. The behavior detection procedure includes processing the diffraction signal to discriminate the locomotor activity of the microorganism. The invention may be used in the chronobiological field, longevity, toxicity and pharmacology studies.

Classes IPC  ?

• A61B 5/11 - Mesure du mouvement du corps entier ou de parties de celui-ci, p. ex. tremblement de la tête ou des mains ou mobilité d'un membre

Abrégé

A method for detecting deglutition in infants and a suction, deglutition and respiration coordination diagnosis and recording device during milk ingestion of preterm infants using the same. The method allows diagnosing and recording when the preterm infant is capable of co-i ordinating respiration and deglutition, providing a document of the measurements recorded, such as in case of an electrocardiogram or electroencephalogram, with a certain and incontrovertible legal value.

Classes IPC  ?

• A61B 5/11 - Mesure du mouvement du corps entier ou de parties de celui-ci, p. ex. tremblement de la tête ou des mains ou mobilité d'un membre
• A61B 7/00 - Instruments d'auscultation
• A61B 5/0488 - Electromyographie

Abrégé

A sunroof, which is adapted to provide either home passive heating by solar accumulation or passive refrigeration due to its particular structure that additionally provides insulation conditions from the external environment. The sunroof is comprised of structural sheets (4, preferable metallic) over which substantially parallel first and second transparent laminar elements (2, 5) are positioned, defining between said sheets (4) and the second laminar elements (5) a first chamber (6), and forming between first and second laminar elements a second watertight chamber(7); the first chamber is capable of being filled with water as the external and upper surface of the second transparent laminar element, which is filled with water or opaque and/or reflective liquids. Preferably, a stationary reflective cover (1) is positioned over said laminar elements.

Classes IPC  ?

• F24J 2/04 - Collecteurs de chaleur solaire avec fluide vecteur circulant à travers le collecteur
• F24J 2/46 - Parties constitutives, détails ou accessoires de collecteurs de chaleur solaire