A controller communicatively coupled to an ultrasound transducer obtains image data of one or more subregions of the target region; determines a tissue type, a vasculature characteristic, or a microbubble concentration associated with each of the one or more subregions based on the image data; determines an acoustic treatment parameter for each of the one or more subregions based on the tissue type, the vasculature characteristic, or the microbubble concentration respectively associated with each of the one or more subregions; and causes the ultrasound transducer to sonicate the one or more subregions according to the acoustic treatment parameters respectively corresponding to each of the one or more subregions.
Various approaches for microbubble-enhanced ultrasound treatment of target tissue include retrieving a treatment plan stored in memory; causing administration of an exogenous agent in accordance with the treatment plan; causing, in accordance with the treatment plan, an ultrasound transducer to transmit ultrasound waves to the target tissue and generate a focus therein in the presence of administered exogenous agent; receiving, from a monitoring system, a measured parameter value indicating a treatment condition in response to administration of the exogenous agent and transmission of the ultrasound waves during treatment; and adjusting the treatment plan based at least in part on the measured parameter value.
A61M 37/00 - Autres appareils pour introduire des agents dans le corps; Percutanisation, c. à d. introduction de médicaments dans le corps par diffusion à travers la peau
A61M 37/00 - Autres appareils pour introduire des agents dans le corps; Percutanisation, c. à d. introduction de médicaments dans le corps par diffusion à travers la peau
4.
CONTROL OF ULTRASOUND PROCEDURES BY MONITORING MICROBUBBLE RESPONSE
An ultrasound transducer sonicates a target volume to change tissue properties by transmitting a sequence of acoustic pulses to the target volume, while at least one acoustic detector detects an ultrasound reflection signal from the target volume following each acoustic pulse, and a controller (i) estimates an activity of the contrast agent at the target volume based on a comparison between values of a signal parameter in the reflection signals following successive acoustic pulses, and (ii) controls the ultrasound transducer based on the estimated activity so as to change the tissue properties.
A system controllably causes tissue death in a target internal anatomic region. The system includes an ultrasound transducer for sonicating a target region in the presence of a contrast agent therein to cause sufficient damage to blood vessels to kill or change functionality of the tissue supplied by the damaged blood vessels; an acoustic detection system comprising at least one detector for detecting ultrasound reflection signals from the target region following each acoustic pulse; and a controller configured to: (i) control the ultrasound transducer to deliver a series of acoustic pulses to the target region; (ii) receive data from the acoustic detection system characterizing the detected reflection signals; and (iii) based at least in part on the received data from the acoustic detection system, determine a degree of damage to vascular tissue within the target region.
A histotripsy procedure controllably causes tissue destruction in a target internal anatomic region by: sonicating a target region with a series of acoustic pulses; detecting ultrasound reflection signals from the target region; controlling an ultrasound transducer to deliver, to the target region, a sequence of acoustic pulses with sufficient amplitude to induce sufficient cavitation to mechanically rupture tissue therein; receiving data characterizing the detected reflection signals; based on the data, computationally estimating a level or a location of acoustic activity or an acoustic field distribution at the target region; and based on a plurality of acoustic activity level estimations or acoustic field distribution estimations: stopping delivery of the acoustic pulses; continuing delivery of the acoustic pulses at a constant power level; increasing a power level for delivery of the acoustic pulses; or decreasing a power level for delivery of the acoustic pulses.
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
Downloadable software for use in medical screening,
diagnostics, and medical therapy, namely, for conducting
guided ultrasound; downloadable computer software, namely,
for the management and operation of medical ultrasound
systems sold as a component of an ultrasound apparatus for
therapeutic and diagnostic medical purposes; downloadable
software for use in the treatment of neurological,
oncological, gynecological, and urological disease by means
of guided ultrasound; downloadable computer software for use
in the treatment of central nervous system disorders,
neurodegenerative disease, neuro-oncological disease,
neuropsychiatric and behavioral disorders, movement
disorders, prostate cancer, uterine fibroids and bone
metastases by means of guided ultrasound sold as a component
of an ultrasound apparatus for therapeutic and diagnostic
medical purposes. Medical ultrasound apparatus; ultrasound diagnostic
apparatus and user manuals sold as a unit therewith;
ultrasound apparatus for therapeutic and diagnostic medical
procedures in the fields of neurology, oncology, gynecology
and urology; ultrasound apparatus for therapeutic and
diagnostic medical procedures with respect to central
nervous system disorders, neurodegenerative disease,
neuro-oncological disease, neuropsychiatric and behavioral
disorders, movement disorders, prostate cancer, uterine
fibroids and bone metastases; ultrasound apparatus for
therapeutic and diagnostic medical procedures, namely, for
use in the ablation of tissue, sonication of tissue, and
disruption of the blood brain barrier, by itself or in
combination with other therapies.
Compound material containing resonators to be used in connection with medical ultrasound apparatus to facilitate lowering of the blood brain barrier; Compound material containing resonators to be used in connection with ultrasound apparatus for therapeutic and diagnostic medical procedures in the fields of neurology, oncology, gynecology and urology; Compound material containing resonators to be used in connection with ultrasound apparatus for therapeutic and diagnostic medical procedures with respect to central nervous system disorders, neurodegenerative disease, neuro-oncological disease, neuropsychiatric and behavioral disorders, movement disorders, prostate cancer, uterine fibroids and bone metastases; Compound material containing resonators to be used in connection with ultrasound apparatus for therapeutic and diagnostic medical procedures, namely, for use in the ablation of tissue, sonication of tissue, and disruption of the blood brain barrier
Compound material containing resonators to be used in connection with medical ultrasound apparatus to facilitate lowering of the blood brain barrier; Compound material containing resonators to be used in connection with ultrasound apparatus for therapeutic and diagnostic medical procedures in the fields of neurology, oncology, gynecology and urology; Compound material containing resonators to be used in connection with ultrasound apparatus for therapeutic and diagnostic medical procedures with respect to central nervous system disorders, neurodegenerative disease, neuro-oncological disease, neuropsychiatric and behavioral disorders, movement disorders, prostate cancer, uterine fibroids and bone metastases; Compound material containing resonators to be used in connection with ultrasound apparatus for therapeutic and diagnostic medical procedures, namely, for use in the ablation of tissue, sonication of tissue, and disruption of the blood brain barrier
An ultrasound transducer includes a plurality of regions, wherein each region of the plurality of regions comprises an active portion including one or more transducer elements placed in random or non-regular positions with respect to transducer elements included in neighboring regions, and an inactive portion including one or more inactive transducer elements or an area with no transducer elements. A controller is configured to: (a) select a first subset of transducer elements of a first plurality of the active portions of the plurality of regions; and (b) drive the first subset of transducer elements to generate a first focal zone of acoustic energy at a first target region.
G10K 11/34 - Procédés ou dispositifs pour transmettre, conduire ou diriger le son pour focaliser ou pour diriger le son, p.ex. balayage par commande électrique de systèmes de transducteurs, p.ex. en dirigeant un faisceau acoustique
Various approaches of focusing an ultrasound transducer having multiple transducer elements to a target region include generating at least one acoustic reflector in the target region; transmitting ultrasound waves to the acoustic reflector; measuring reflections off the acoustic reflector; and based at least in part on the measured reflections, adjusting the parameter value associated with the transducer element(s).
A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
A61B 8/08 - Détection de mouvements ou de changements organiques, p.ex. tumeurs, kystes, gonflements
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets
A61B 17/22 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets pour l'élimination non prévue ailleurs des obstructions dans les vaisseaux sanguins
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p.ex. pour le traitement de la luxation ou pour la protection de bords de blessures
Various approaches for focusing an ultrasound transducer having multiple transducer elements include causing the transducer elements to transmit ultrasound waves to a first one or more target regions and measure reflections of the ultrasound waves off the first one or more target regions; and based at least in part on the measured reflections, determining a parameter value associated with at least one of the transducer elements so as to generate an ultrasound focus at a second target region, different from the first one or more target regions.
A61B 8/08 - Détection de mouvements ou de changements organiques, p.ex. tumeurs, kystes, gonflements
A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiques; Mesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p.ex. formation d'images par résonance magnétique
Various approaches for computationally generating a protocol for treatment of one or more target BBB regions within a tissue region of interest using a source of focused ultrasound include specifying (i) settings of sonication parameters for applying one or more sequence of sonications to the target BBB region using the source of focused ultrasound and (ii) a characteristic of microbubbles selected to be administered into the target BBB region; electronically simulating treatment in accordance with the protocol at least in part by computationally executing the sequence(s) of sonications and computationally administering the microbubbles having the characteristic; and computationally predicting a tissue disruption effect of the target BBB region resulting from the treatment.
A61N 5/10 - Radiothérapie; Traitement aux rayons gamma; Traitement par irradiation de particules
A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
A61B 34/10 - Planification, simulation ou modélisation assistées par ordinateur d’opérations chirurgicales
A61M 37/00 - Autres appareils pour introduire des agents dans le corps; Percutanisation, c. à d. introduction de médicaments dans le corps par diffusion à travers la peau
Systems and methods for treating target tissue include generating a priming sequence of sonication pulses for delivering acoustic energy to the target tissue; pausing generation of the sonication pulses for a delay interval; and generating a series of treatment sequences of sonication pulses for delivering acoustic energy to the target tissue, the treatment sequences having sonication intervals therebetween and the delay interval being larger than the largest sonication interval by a predetermined factor.
A system (100) for controlling drug delivery through a tissue barrier includes an ultrasound transducer (104) and a controller (108). The ultrasound transducer is for sonicating a target volume to cause disruption of the tissue barrier and thereby increase a permeability thereof. The controller is configured to receive a specification of a target molecule, where the specification includes a pharmacokinetic parameter of the target molecule or a molecular size of the target molecule. The controller is also configured to operate the ultrasound transducer in accordance with the specification to permit passage of the target molecule through the tissue barrier in a manner that traps a target fraction of the target molecule behind the tissue barrier for a predetermined time period.
A61M 37/00 - Autres appareils pour introduire des agents dans le corps; Percutanisation, c. à d. introduction de médicaments dans le corps par diffusion à travers la peau
16.
SYSTEMS AND METHODS FOR REGISTERING IMAGES OBTAINED USING DIFFERENT IMAGING MODALITIES
Different imaging modalities are registered to a common coordinate reference frame or to each other by utilizing transient or clinically harmless tissue disruptions created at a known anatomic location. These are visualized by both imaging systems, enabling their registration.
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p.ex. pour le traitement de la luxation ou pour la protection de bords de blessures
A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiques; Mesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p.ex. formation d'images par résonance magnétique
17.
MULTIPARAMETRIC OPTIMIZATION FOR ULTRASOUND PROCEDURES
Focused-ultrasound systems and methods involve simultaneously determining multiple ultrasound parameters (e.g., applied acoustic power, frequency, phases, position, activation pattern, beam shape, wave shape, etc.) associated with the transducer array for generating optimal treatment effects both at the target region (e.g., causing a sufficient temperature increase for tissue necrosis to occur) and non-target region (e.g., having a clinically insignificant temperature increase to avoid damage to the non-target tissue). A computational model may simulate the treatment effects (e.g., the temperature, peak intensity, focus shape, location of the hot spot, etc.) of these ultrasound parameters on the target and/or non-target regions. Based on the simulation results, the computational model may simultaneously determine the optimal values of the multiple ultrasound parameters—i.e., the values that, while not necessarily optimal for each individual parameter considered in isolation, nonetheless produce optimal overall treatment effects at the target and non-target
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p.ex. pour le traitement de la luxation ou pour la protection de bords de blessures
A61B 34/10 - Planification, simulation ou modélisation assistées par ordinateur d’opérations chirurgicales
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
Downloadable software for use in medical screening, diagnostics, and medical therapy, namely, for conducting guided ultrasound; downloadable computer software, namely, for the management and operation of medical ultrasound systems sold as a component of an ultrasound apparatus for therapeutic and diagnostic medical purposes; downloadable software for use in the treatment of neurological, oncological, gynecological, and urological disease by means of guided ultrasound; downloadable computer software for use in the treatment of central nervous system disorders, neurodegenerative disease, neuro-oncological disease, neuropsychiatric and behavioral disorders, movement disorders, prostate cancer, uterine fibroids and bone metastases by means of guided ultrasound sold as a component of an ultrasound apparatus for therapeutic and diagnostic medical purposes Medical ultrasound apparatus; ultrasound diagnostic apparatus and user manuals sold as a unit therewith; ultrasound apparatus for therapeutic and diagnostic medical procedures in the fields of neurology, oncology, gynecology and urology; ultrasound apparatus for therapeutic and diagnostic medical procedures with respect to central nervous system disorders, neurodegenerative disease, neuro-oncological disease, neuropsychiatric and behavioral disorders, movement disorders, prostate cancer, uterine fibroids and bone metastases; ultrasound apparatus for therapeutic and diagnostic medical procedures, namely, for use in the ablation of tissue, sonication of tissue, and disruption of the blood brain barrier, by itself or in combination with other therapies
19.
COMPOSITE STRUCTURAL ADHESIVE COMPOSITIONS AND RELATED METHODS
The various implementations described herein include adhesive compositions for high- voltage focused ultrasound applications. In one aspect, an ultrasound transducer comprises a plurality of tiles. Each tile includes a first electrically conductive layer, a second electrically conductive layer, a plurality of transducer elements disposed between the first electrically conductive layer and the second electrically conductive layer, and a composite structural adhesive (a) disposed between the first electrically conductive layer and the second electrically conductive layer and (b) disposed between respective adjacent transducer elements of the plurality of transducer elements. The composite structural adhesive includes an epoxy resin, fumed silica, and a powder selected from the group consisting of: (i) micronized mica, (ii) bioactive glass powder, and (iii) micronized mica and bioactive glass powder.
B06B 1/06 - Procédés ou appareils pour produire des vibrations mécaniques de fréquence infrasonore, sonore ou ultrasonore utilisant l'énergie électrique fonctionnant par effet piézo-électrique ou par électrostriction
20.
MONITORING TISSUE PERMEABILITY DURING ULTRASOUND PROCEDURES
The disclosure relates, in part, to targeted drug delivery using an ultrasound procedure and, more particularly, to systems and methods for the measurement of levels of drug delivery and certain aspects of metabolism, such as drug metabolism, in the brain tissue.
A61M 37/00 - Autres appareils pour introduire des agents dans le corps; Percutanisation, c. à d. introduction de médicaments dans le corps par diffusion à travers la peau
A61B 17/22 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets pour l'élimination non prévue ailleurs des obstructions dans les vaisseaux sanguins
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets
Conformal ultrasound transducer arrangements and supporting registration systems and methods enable automated mapping of transducer elements to the internal anatomy of a patient. Once established, the mapping remains valid despite patient movements, and can be used to select transducer elements and their relative phases so as to create a high-energy focus at an internal target of interest without damage to intervening non-target tissue.
A61B 90/90 - Moyens d’identification pour les patients ou les instruments, p.ex. étiquettes
A61B 90/96 - Moyens d’identification pour les patients ou les instruments, p.ex. étiquettes utilisant des symboles, p.ex. du texte utilisant des codes-barres
A61B 90/94 - Moyens d’identification pour les patients ou les instruments, p.ex. étiquettes utilisant des symboles, p.ex. du texte
22.
Systems and Methods for Selective, Targeted Tissue Disruption
Systems and methods for temporarily altering a tissue characteristic at a target region, such as the blood-brain barrier, include causing an ultrasound transducer to transmit acoustic energy to the target region at a transmission frequency; acquiring a cumulative harmonic response from at least the target region; and operating the transducer based at least in part on the acquired cumulative harmonic response.
A61M 37/00 - Autres appareils pour introduire des agents dans le corps; Percutanisation, c. à d. introduction de médicaments dans le corps par diffusion à travers la peau
A61K 41/00 - Préparations médicinales obtenues par traitement de substances par énergie ondulatoire ou par rayonnement corpusculaire
Sonodynamic therapy systems and methods use short, high-pressure ultrasound pulses that produce small (and therefore clinically safe) increases (up to 1-2 °C) in tissue temperature but nonetheless activate sonodynamic agents, allowing isolated single-cavitation events to produce therapeutically beneficial effects (e.g., cytotoxicity) on diseased tissue. An escalating sonication strategy may be employed whereby the focal pressure is gradually increased until maximum clinically tolerable parameters such as the degree of heating of intervening tissue (e.g., the skull when treating brain cancer) or undesired induced cavitation effects are reached.
Systems and methods are provided for initializing an ultrasound procedure for a target region. The method includes determining a distribution of vessel diameters of vasculature in a target region. The method also includes providing, at the target region, microbubbles having a size distribution related to the distribution of vessel diameters.
In an ultrasound system, echo focusing is performed to align ultrasound pulse peaks, establishing the phase delay required for each ultrasound transducer element, and the temporal displacements among pulses are determined using, for example, time-of-flight (ToF) measurements. The combined approach aligns the phases and the envelopes of pulses delivered by the active transducer elements that contribute energy during treatment. Moreover, it permits long pulses to be used for phase alignment in the preparatory stage and perfectly aligned short pulses in the sonication stage.
Transducer elements have one or more asymmetric features that give rise to multiple natural resonance frequencies. The feature(s) can be discrete (e.g., steps, bars, or gemstone-like facets) or continuous across one or more dimensions of the transducer element (e.g., a triangular prism). A transducer element can be driven at more than one resonance frequency; multiple frequencies will excite more than one feature in parallel, each producing an output emission with a characteristic frequency and phase. An optimal frequency—i.e., one that maximizes the peak acoustic intensity or acoustic power at the target—within a certain frequency range may be determined, and a plurality of asymmetric transducer elements may be driven at a center frequency that coincides with or is close to this optimal frequency.
A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
A61B 8/08 - Détection de mouvements ou de changements organiques, p.ex. tumeurs, kystes, gonflements
B06B 1/02 - Procédés ou appareils pour produire des vibrations mécaniques de fréquence infrasonore, sonore ou ultrasonore utilisant l'énergie électrique
27.
VARIABLE-BANDWIDTH TRANSDUCERS WITH ASYMMETRIC FEATURES
Transducer elements have one or more asymmetric features that give rise to multiple natural resonance frequencies. The feature(s) can be discrete (e.g., steps, bars, or gemstone-like facets) or continuous across one or more dimensions of the transducer element (e.g., a triangular prism). A transducer element can be driven at more than one resonance frequency; multiple frequencies will excite more than one feature in parallel, each producing an output emission with a characteristic frequency and phase. An optimal frequency — i.e., one that maximizes the peak acoustic intensity or acoustic power at the target — within a certain frequency range may be determined, and a plurality of asymmetric transducer elements may be driven at a center frequency that coincides with or is close to this optimal frequency.
B06B 1/06 - Procédés ou appareils pour produire des vibrations mécaniques de fréquence infrasonore, sonore ou ultrasonore utilisant l'énergie électrique fonctionnant par effet piézo-électrique ou par électrostriction
28.
DIFFERENTIAL PREDICTION OF ABERRATION CORRECTIONS FOR ULTRASOUND THERAPY
Various approaches for delivering ultrasound energy to a target region during a therapeutic or diagnostic procedure includes implementing an adjustment mechanism having a machine-learning model that has been trained, based on input vectors corresponding to a difference and/or a ratio of parameter values between multiple transducer elements, to generate, for each of the transducer elements, one or more parameter value to compensate for expected beam aberration resulting for an intervening tissue; and activating the transducer elements in accordance with the corresponding parameter values so as to generate an optimized focal zone at the target region during the therapeutic or diagnostic procedure.
A61M 37/00 - Autres appareils pour introduire des agents dans le corps; Percutanisation, c. à d. introduction de médicaments dans le corps par diffusion à travers la peau
Approaches for performing magnetic resonance (MR) imaging of an anatomic region in conjunction with an ultrasound operation on the anatomic region include transmitting multiple ultrasound waves or pulses having a fundamental frequency and multiple harmonics to the anatomic region; transmitting an MR pulse sequence to the anatomic region and receiving, therefrom, MR signals within a band of frequencies; and causing the band of frequencies to be located between two adjacent frequencies of the harmonics.
Approaches for focusing an ultrasound transducer having multiple transducer elements include generating the first sonication to one or more target regions and measuring the first set of reflection signals resulting from the first sonication; based on the first set of reflection signals, determining whether a target number or a target occurrence rate of focusing events has been reached; if not, generating the second sonication at an adjusted acoustic power to the target region(s) and measuring the second set of reflection signals resulting from the second sonication; and based at least in part on the second set of reflection signals, adjusting a parameter value associated with one or more transducer elements so as to improve an ultrasound focus at the target region(s).
Various approaches for computationally characterizing tissue in an anatomic target region include generating multiple sonications to transient acoustic reflectors at or proximate to the target region; measuring reflection signals of the sonications off the transient acoustic reflectors; based on the measurements, identifying the reflection signals originating from single transient acoustic reflectors; and based at least in part on the identified reflection signals, generating a digital map including a tissue characteristic.
G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides
34.
ABERRATION CORRECTIONS FOR DYNAMICALLY CHANGING MEDIA DURING ULTRASOUND THERAPY
Various approaches to delivering ultrasound energy to a target region include, prior to delivery of the ultrasound energy, populating a data structure relating multiple real-time parameter values to corresponding correction values for one or more ultrasound parameter values associated with one or more transducer elements for generating a focal zone of acoustic energy in at least the first portion of the target region; and during the treatment, (i) predicting or causing measurement of at least one of the real-time parameter values in the second portion of the target region or the non-target region; (ii) based at least in part on the predicted or measured real-time parameter value(s) and contents of the data structure, determine the correction value(s) for the ultrasound parameter value(s); and (iii) activate the transducer element(s) based at least in part on the determined correction value(s) for the ultrasound parameter value(s) so as to generate the focal zone in the second portion of the target region.
G16H 20/30 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p.ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies ou des activités physiques, p.ex. la physiothérapie, l’acupression ou les exercices
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
35.
Magnetic resonance (MR) performance in MR-guided ultrasound systems
− field distribution in an MRI apparatus to improve the signal sensitivity and homogeneity at a region of interest. Approaches employed include strategic placement of field-altering features such as slots and/or dipoles along the exterior surface or, in some cases, the interior of the transducer. In various embodiments, the field-altering features are (or behave as) passive resonators.
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p.ex. pour le traitement de la luxation ou pour la protection de bords de blessures
G01R 33/341 - Systèmes d'excitation ou de détection, p.ex. utilisant des signaux radiofréquence - Détails de structure, p.ex. résonateurs comprenant des bobines de surface
Systems and methods provide accelerated MR thermometry utilizing prior knowledge about the images to be reconstructed from incomplete k-space data, thereby facilitating accurate reconstruction. In various embodiments, missing data is computationally estimated using a machine learning algorithm such as a neural network, and an image is generated based on iteratively updated estimated missing information.
G01V 3/00 - Prospection ou détection électrique ou magnétique; Mesure des caractéristiques du champ magnétique de la terre, p.ex. de la déclinaison ou de la déviation
A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiques; Mesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p.ex. formation d'images par résonance magnétique
G01R 33/50 - Systèmes d'imagerie RMN basés sur la détermination des temps de relaxation
G01R 33/56 - Amélioration ou correction de l'image, p.ex. par des techniques de soustraction ou d'établissement de moyenne
G01R 33/561 - Amélioration ou correction de l'image, p.ex. par des techniques de soustraction ou d'établissement de moyenne par réduction du temps de balayage, c.à d. systèmes d'acquisition rapide, p.ex. utilisant des séquences d'impulsions écho-planar
Focused-ultrasound systems and methods involve simultaneously determining multiple ultrasound parameters (e.g., applied acoustic power, frequency, phases, position, activation pattern, beam shape, wave shape, etc.) associated with the transducer array for generating optimal treatment effects both at the target region (e.g., causing a sufficient temperature increase for tissue necrosis to occur) and non-target region (e.g., having a clinically insignificant temperature increase to avoid damage to the non-target tissue). A computational model may simulate the treatment effects (e.g., the temperature, peak intensity, focus shape, location of the hot spot, etc.) of these ultrasound parameters on the target and/or non-target regions. Based on the simulation results, the computational model may simultaneously determine the optimal values of the multiple ultrasound parameters — i.e., the values that, while not necessarily optimal for each individual parameter considered in isolation, nonetheless produce optimal overall treatment effects at the target and non-target regions (e.g., maximal energy absorption and highest intensity (or energy density) at the target and minimal energy deposition at the non-target region).
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p.ex. pour le traitement de la luxation ou pour la protection de bords de blessures
A61B 34/10 - Planification, simulation ou modélisation assistées par ordinateur d’opérations chirurgicales
Various approaches for focusing an ultrasound transducer include introducing at least one transient acoustic reflector located in proximity to at least one target region; generating multiple sonications to the at least one target region; measuring a reflection signal of each of the sonications off the at least one transient acoustic reflector; selecting the measured reflection signals, and based at least in part on the selected reflection signals, adjusting a parameter value associated with at least one of the transducer elements so as to improve an ultrasound focus at the target region.
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Computer software for use in medical screening, diagnostics,
and medical therapy; computer software, namely, for the
management and operation of medical ultrasound systems;
computer software for use in the treatment of neurological,
oncological, gynecological, and urological disease; computer
software for use in the treatment of central nervous system
disorders, neurodegenerative disease, neuro-oncological
disease, neuropsychiatric and behavioral disorders, movement
disorders, prostate cancer, uterine fibroids and bone
metastases. Medical ultrasound apparatus and related accessories;
ultrasound apparatus and related accessories for therapeutic
and diagnostic medical procedures, and user manuals sold as
a unit therewith; ultrasound apparatus and related
accessories for therapeutic and diagnostic medical
procedures in the fields of neurology, oncology, gynecology
and urology; ultrasound apparatus and related accessories
for therapeutic and diagnostic medical procedures with
respect to central nervous system disorders,
neurodegenerative disease, neuro-oncological disease,
neuropsychiatric and behavioral disorders, movement
disorders, prostate cancer, uterine fibroids and bone
metastases; ultrasound apparatus and related accessories for
therapeutic and diagnostic medical procedures, including
through the ablation of tissue, sonication of tissue, and
disruption of the blood brain barrier, by itself or in
combination with other therapies. Providing online medical information; providing online
medical information regarding ultrasound treatment;
providing medical information via a website in the fields of
neurology, oncology, gynecology, and urology; providing
medical information, consultancy, and advisory services in
the fields of neurology, oncology, gynecology, and urology;
providing medical information, consultancy, and advisory
services with respect to ultrasound treatment of central
nervous system disorders, neurodegenerative disease,
neuro-oncological disease, neuropsychiatric and behavioral
disorders, movement disorders, prostate cancer, uterine
fibroids and bone metastases.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
35 - Publicité; Affaires commerciales
Produits et services
Pharmaceuticals for use in disrupting the blood brain
barrier; pharmaceuticals for use in the treatment and
diagnosis of neurological and oncological disease;
pharmaceuticals for use with respect to ultrasound treatment
and diagnosis of neurodegenerative disease and cancer. Sale and distribution of pharmaceuticals of others for use
with ultrasound treatment and diagnosis in the fields of
neurology, neurosurgery and oncology; sale and distribution
of pharmaceuticals for use with ultrasound treatment and
diagnosis of neurodegenerative disease and cancer.
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
Computer software for use in medical screening, diagnostics,
and medical therapy; computer software, namely, for the
management and operation of medical ultrasound systems;
computer software for use in the treatment of neurological,
oncological, gynecological, and urological disease; computer
software for use in the treatment of central nervous system
disorders, neurodegenerative disease, neuro-oncological
disease, neuropsychiatric and behavioral disorders, movement
disorders, prostate cancer, uterine fibroids and bone
metastases. Medical ultrasound apparatus and related accessories;
ultrasound apparatus and related accessories for therapeutic
and diagnostic medical procedures, and user manuals sold as
a unit therewith; ultrasound apparatus and related
accessories for therapeutic and diagnostic medical
procedures in the fields of neurology, oncology, gynecology
and urology; ultrasound apparatus and related accessories
for therapeutic and diagnostic medical procedures with
respect to central nervous system disorders,
neurodegenerative disease, neuro-oncological disease,
neuropsychiatric and behavioral disorders, movement
disorders, prostate cancer, uterine fibroids and bone
metastases; ultrasound apparatus and related accessories for
therapeutic and diagnostic medical procedures, including
through the ablation of tissue, sonication of tissue, and
disruption of the blood brain barrier, by itself or in
combination with other therapies.
42.
DIFFERENTIAL PREDICTION OF ABERRATION CORRECTIONS FOR ULTRASOUND THERAPY
Various approaches for delivering ultrasound energy to a target region during a therapeutic or diagnostic procedure includes implementing an adjustment mechanism having a machine-learning model that has been trained, based on input vectors corresponding to a difference and/or a ratio of parameter values between multiple transducer elements, to generate, for each of the transducer elements, one or more parameter value to compensate for expected beam aberration resulting for an intervening tissue; and activating the transducer elements in accordance with the corresponding parameter values so as to generate an optimized focal zone at the target region during the therapeutic or diagnostic procedure.
Various approaches for heating a target region substantially uniformly include identifying one or more locations of one or more hot spots in the target region and/or surrounding regions of the target region during an ultrasound sonication process; computing a temporal variation to an output parameter of at least one of the transducer elements based at least in part on the identified location(s) of the hot spot(s); and operating the at least one transducer element to achieve the temporal variation of the output parameter so as to minimize the hot spot(s).
A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiques; Mesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p.ex. formation d'images par résonance magnétique
A61B 8/08 - Détection de mouvements ou de changements organiques, p.ex. tumeurs, kystes, gonflements
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
(1) Downloadable software for use in medical screening, diagnostics, and medical therapy, namely, for conducting guided ultrasound; downloadable computer software, namely, for the management and operation of medical ultrasound systems sold as a component of an ultrasound apparatus for therapeutic and diagnostic medical purposes; downloadable software for use in the treatment of neurological, oncological, gynecological, and urological disease by means of guided ultrasound; downloadable computer software for use in the treatment of central nervous system disorders, neurodegenerative disease, neuro-oncological disease, neuropsychiatric and behavioral disorders, movement disorders, prostate cancer, uterine fibroids and bone metastases by means of guided ultrasound sold as a component of an ultrasound apparatus for therapeutic and diagnostic medical purposes.
(2) Medical ultrasound apparatus; ultrasound diagnostic apparatus and user manuals sold as a unit therewith; ultrasound apparatus for therapeutic and diagnostic medical procedures in the fields of neurology, oncology, gynecology and urology; ultrasound apparatus for therapeutic and diagnostic medical procedures with respect to central nervous system disorders, neurodegenerative disease, neuro-oncological disease, neuropsychiatric and behavioral disorders, movement disorders, prostate cancer, uterine fibroids and bone metastases; ultrasound apparatus for therapeutic and diagnostic medical procedures, namely, for use in the ablation of tissue, sonication of tissue, and disruption of the blood brain barrier, by itself or in combination with other therapies.
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
(1) Downloadable software for use in medical screening, diagnostics, and medical therapy, namely, for conducting guided ultrasound; downloadable computer software, namely, for the management and operation of medical ultrasound systems sold as a component of an ultrasound apparatus for therapeutic and diagnostic medical purposes; downloadable software for use in the treatment of neurological, oncological, gynecological, and urological disease by means of guided ultrasound; downloadable computer software for use in the treatment of central nervous system disorders, neurodegenerative disease, neuro-oncological disease, neuropsychiatric and behavioral disorders, movement disorders, prostate cancer, uterine fibroids and bone metastases by means of guided ultrasound sold as a component of an ultrasound apparatus for therapeutic and diagnostic medical purposes.
(2) Medical ultrasound apparatus; ultrasound apparatus for therapeutic and diagnostic medical procedures, and user manuals sold as a unit therewith; ultrasound apparatus for therapeutic and diagnostic medical procedures in the fields of neurology, oncology, gynecology and urology; ultrasound apparatus for therapeutic and diagnostic medical procedures with respect to central nervous system disorders, neurodegenerative disease, neuro-oncological disease, neuropsychiatric and behavioral disorders, movement disorders, prostate cancer, uterine fibroids and bone metastases; ultrasound apparatus for therapeutic and diagnostic medical procedures, namely, the ablation of tissue, sonication of tissue, and disruption of the blood brain barrier, by itself or in combination with other therapies. (1) Providing online medical information; providing online medical information regarding ultrasound treatment; providing medical information via a website in the fields of neurology, oncology, gynecology, and urology; providing medical information, consultancy, and advisory services in the fields of neurology, oncology, gynecology, and urology; providing medical information, consultancy, and advisory services with respect to ultrasound treatment of central nervous system disorders, neurodegenerative disease, neuro-oncological disease, neuropsychiatric and behavioral disorders, movement disorders, prostate cancer, uterine fibroids and bone metastases.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
35 - Publicité; Affaires commerciales
Produits et services
(1) Pharmaceuticals for use in disrupting the blood brain barrier; pharmaceuticals for use in the treatment and diagnosis of oncological disease; pharmaceuticals for use in the treatment and diagnosis of neurological disease, namely Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, ALS, Cerebral Palsy, Neurogenetic Deficiencies, Neurodegenerative Disease, Neuropsychiatric Disease, Neuro-Oncology, including primary and secondary brain tumors, Glioma/Glioblastoma, DMG/DIPG, Medullobastoma, Brain Metatases; pharmaceuticals for use with respect to ultrasound treatment and diagnosis of neurodegenerative disease and cancer. (1) Sale and distribution of pharmaceuticals of others for use with ultrasound treatment and diagnosis in the fields of neurology, neurosurgery and oncology; sale and distribution of pharmaceuticals for use with ultrasound treatment and diagnosis of neurodegenerative disease and cancer.
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Downloadable software for use in medical screening, diagnostics, and medical therapy, namely, for conducting guided ultrasound; downloadable computer software, namely, for the management and operation of medical ultrasound systems sold as a component of an ultrasound apparatus for therapeutic and diagnostic medical purposes; downloadable software for use in the treatment of neurological, oncological, gynecological, and urological disease by means of guided ultrasound; downloadable computer software for use in the treatment of central nervous system disorders, neurodegenerative disease, neuro-oncological disease, neuropsychiatric and behavioral disorders, movement disorders, prostate cancer, uterine fibroids and bone metastases by means of guided ultrasound sold as a component of an ultrasound apparatus for therapeutic and diagnostic medical purposes Medical ultrasound apparatus; ultrasound apparatus for therapeutic and diagnostic medical procedures, and user manuals sold as a unit therewith; ultrasound apparatus for therapeutic and diagnostic medical procedures in the fields of neurology, oncology, gynecology and urology; ultrasound apparatus for therapeutic and diagnostic medical procedures with respect to central nervous system disorders, neurodegenerative disease, neuro-oncological disease, neuropsychiatric and behavioral disorders, movement disorders, prostate cancer, uterine fibroids and bone metastases; ultrasound apparatus for therapeutic and diagnostic medical procedures, namely, the ablation of tissue, sonication of tissue, and disruption of the blood brain barrier, by itself or in combination with other therapies Providing online medical information; providing online medical information regarding ultrasound treatment; providing a website featuring medical information in the fields of neurology, oncology, gynecology, and urology via the internet; providing medical information, consultancy, and advisory services in the fields of neurology, oncology, gynecology, and urology; providing medical information, consultancy, and advisory services with respect to ultrasound treatment of central nervous system disorders, neurodegenerative disease, neuro-oncological disease, neuropsychiatric and behavioral disorders, movement disorders, prostate cancer, uterine fibroids and bone metastases
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
Downloadable software for use in medical screening, diagnostics, and medical therapy, namely, for conducting guided ultrasound; downloadable computer software, namely, for the management and operation of medical ultrasound systems sold as a component of an ultrasound apparatus for therapeutic and diagnostic medical purposes; downloadable software for use in the treatment of neurological, oncological, gynecological, and urological disease by means of guided ultrasound; downloadable computer software for use in the treatment of central nervous system disorders, neurodegenerative disease, neuro-oncological disease, neuropsychiatric and behavioral disorders, movement disorders, prostate cancer, uterine fibroids and bone metastases by means of guided ultrasound sold as a component of an ultrasound apparatus for therapeutic and diagnostic medical purposes Medical ultrasound apparatus; ultrasound diagnostic apparatus and user manuals sold as a unit therewith; ultrasound apparatus for therapeutic and diagnostic medical procedures in the fields of neurology, oncology, gynecology and urology; ultrasound apparatus for therapeutic and diagnostic medical procedures with respect to central nervous system disorders, neurodegenerative disease, neuro-oncological disease, neuropsychiatric and behavioral disorders, movement disorders, prostate cancer, uterine fibroids and bone metastases; ultrasound apparatus for therapeutic and diagnostic medical procedures, namely, for use in the ablation of tissue, sonication of tissue, and disruption of the blood brain barrier, by itself or in combination with other therapies
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Downloadable software for use in medical screening, diagnostics, and medical therapy, namely, for conducting guided ultrasound; downloadable computer software, namely, for the management and operation of medical ultrasound systems sold as a component of an ultrasound apparatus for therapeutic and diagnostic medical purposes; downloadable software for use in the treatment of neurological, oncological, gynecological, and urological disease by means of guided ultrasound; downloadable computer software for use in the treatment of central nervous system disorders, neurodegenerative disease, neuro-oncological disease, neuropsychiatric and behavioral disorders, movement disorders, prostate cancer, uterine fibroids and bone metastases by means of guided ultrasound sold as a component of an ultrasound apparatus for therapeutic and diagnostic medical purposes Medical ultrasound apparatus; ultrasound apparatus for therapeutic and diagnostic medical procedures, and user manuals sold as a unit therewith; ultrasound apparatus for therapeutic and diagnostic medical procedures in the fields of neurology, oncology, gynecology and urology; ultrasound apparatus for therapeutic and diagnostic medical procedures with respect to central nervous system disorders, neurodegenerative disease, neuro-oncological disease, neuropsychiatric and behavioral disorders, movement disorders, prostate cancer, uterine fibroids and bone metastases; ultrasound apparatus for therapeutic and diagnostic medical procedures, namely, the ablation of tissue, sonication of tissue, and disruption of the blood brain barrier, by itself or in combination with other therapies Providing online medical information; providing online medical information regarding ultrasound treatment; providing a website featuring medical information in the fields of neurology, oncology, gynecology, and urology via the internet; providing medical information, consultancy, and advisory services in the fields of neurology, oncology, gynecology, and urology; providing medical information, consultancy, and advisory services with respect to ultrasound treatment of central nervous system disorders, neurodegenerative disease, neuro-oncological disease, neuropsychiatric and behavioral disorders, movement disorders, prostate cancer, uterine fibroids and bone metastases
05 - Produits pharmaceutiques, vétérinaires et hygièniques
35 - Publicité; Affaires commerciales
Produits et services
Pharmaceutical preparations for use in disrupting the blood brain barrier for the treatment of neurological and oncological disease; pharmaceutical preparations for use in the treatment and diagnosis of neurological and oncological disease; pharmaceutical preparations for use with respect to ultrasound treatment and diagnosis of neurodegenerative disease and cancer Wholesale and retail distributorships featuring pharmaceuticals of others for use with ultrasound treatment and diagnosis in the fields of neurology, neurosurgery and oncology; wholesale and retail distributorships featuring pharmaceuticals for use with ultrasound treatment and diagnosis of neurodegenerative disease and cancer
05 - Produits pharmaceutiques, vétérinaires et hygièniques
35 - Publicité; Affaires commerciales
Produits et services
Pharmaceutical preparations for use in disrupting the blood brain barrier for the treatment of neurological and oncological disease; pharmaceutical preparations for use in the treatment and diagnosis of neurological and oncological disease; pharmaceutical preparations for use with respect to ultrasound treatment and diagnosis of neurodegenerative disease and cancer Wholesale and retail distributorships featuring pharmaceuticals of others for use with ultrasound treatment and diagnosis in the fields of neurology, neurosurgery and oncology; wholesale and retail distributorships featuring pharmaceuticals for use with ultrasound treatment and diagnosis of neurodegenerative disease and cancer
54.
Focused ultrasound system with optimized monitoring of cavitation
Various approaches for generating an ultrasound focus at a target region and receiving signals therefrom using an ultrasound transducer having multiple transducer elements include acquiring multiple images of the target region and one or more path zones located on beam paths between the transducer elements and the target region; determining one or more tissue characteristics associated with the target region based on the acquired images; determining multiple profile parameters associated with each of the transducer elements based at least in part on the determined tissue characteristic; based at least in part on the profile parameters, operating at least first ones of the transducer elements to collectively transmit an ultrasound beam to the target region so as to create a focus thereon with desired properties; and based at least in part on the profile parameters, operating at least second ones of the transducer elements to receive acoustic signals from the target region and, in response thereto, adjusting operation of the at least first ones of the transducer elements to thereby improve the focus at the target region.
A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
G01S 15/89 - Systèmes sonar, spécialement adaptés à des applications spécifiques pour la cartographie ou la représentation
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p.ex. pour le traitement de la luxation ou pour la protection de bords de blessures
Various approaches for focusing an ultrasound transducer having multiple transducer elements include causing the transducer elements to transmit ultrasound waves to a target region and measure reflections of the ultrasound waves off the target region; for each of at least some of the transducer elements, adjusting a parameter value associated with said each transducer element based at least in part on parameter values associated with multiple measuring transducer elements weighted by signal quality metrics associated with the reflections measured by the measuring transducer elements so as to improve an ultrasound focus at the target region.
A61B 8/08 - Détection de mouvements ou de changements organiques, p.ex. tumeurs, kystes, gonflements
A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiques; Mesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p.ex. formation d'images par résonance magnétique
Various approaches for computationally characterizing tissue in an anatomic target region include generating multiple sonications to transient acoustic reflectors at or proximate to the target region; measuring reflection signals of the sonications off the transient acoustic reflectors; based on the measurements, identifying the reflection signals originating from single transient acoustic reflectors; and based at least in part on the identified reflection signals, generating a digital map including a tissue characteristic.
Approaches for focusing an ultrasound transducer having multiple transducer elements include generating the first sonication to one or more target regions and measuring the first set of reflection signals resulting from the first sonication; based on the first set of reflection signals, determining whether a target number or a target occurrence rate of focusing events has been reached; if not, generating the second sonication at an adjusted acoustic power to the target region(s) and measuring the second set of reflection signals resulting from the second sonication; and based at least in part on the second set of reflection signals, adjusting a parameter value associated with one or more transducer elements so as to improve an ultrasound focus at the target region(s).
Approaches for performing magnetic resonance (MR) imaging of an anatomic region in conjunction with an ultrasound operation on the anatomic region include transmitting multiple ultrasound waves or pulses having a fundamental frequency and multiple harmonics to the anatomic region; transmitting an MR pulse sequence to the anatomic region and receiving, therefrom, MR signals within a band of frequencies; and causing the band of frequencies to be located between two adjacent frequencies of the harmonics.
A61B 8/08 - Détection de mouvements ou de changements organiques, p.ex. tumeurs, kystes, gonflements
A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiques; Mesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p.ex. formation d'images par résonance magnétique
A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
G01R 33/28 - Dispositions ou appareils pour la mesure des grandeurs magnétiques faisant intervenir la résonance magnétique - Détails des appareils prévus dans les groupes
Various approaches to stimulating neural activity in one or more target regions associated with one or more brain diseases or disorders include transmitting the first sequence of ultrasound pulses to the target region(s); measuring a physiological parameter indicative of the neural activity at the target region(s) resulting from the ultrasound pulses; and based at least in part on the measurement, adjusting a parameter value associated with one or more transducer elements so as to achieve a target objective of the neural activity.
Various approaches to focusing an ultrasound transducer includes causing the ultrasound transducer to transmit ultrasound waves to the target region; causing the detection system to indirectly measure the focusing properties; and based at least in part on the indirectly measured focusing properties, adjusting a parameter value associated with at least one of the transducer elements so as to achieve a target treatment power at the target region.
A61M 37/00 - Autres appareils pour introduire des agents dans le corps; Percutanisation, c. à d. introduction de médicaments dans le corps par diffusion à travers la peau
Various approaches for enhancing treatment of target tissue using a source of focused ultrasound while limiting damage to non-target tissue include selecting a frequency of ultrasound waves transmitted from the source of focused ultrasound for generating a focus in the target tissue; providing microbubbles having the first size distribution such that at least 50% of the microbubbles have a radius smaller than a critical radius corresponding to a resonance frequency matching the selected frequency of ultrasound waves; and applying the ultrasound waves at the selected frequency to treat the target tissue.
A61B 34/10 - Planification, simulation ou modélisation assistées par ordinateur d’opérations chirurgicales
A61M 37/00 - Autres appareils pour introduire des agents dans le corps; Percutanisation, c. à d. introduction de médicaments dans le corps par diffusion à travers la peau
A61B 6/12 - Dispositifs pour détecter ou localiser des corps étrangers
Various approaches for disrupting target tissue for treatment include identifying a target volume of the target tissue; causing disruption of the target tissue in a region corresponding to the target volume so as to increase tissue permeability therein; computationally generating a tissue permeability map of the target volume; and based on the tissue permeability map, computationally evaluating the disruption of the target tissue within the target volume.
A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
A61B 34/10 - Planification, simulation ou modélisation assistées par ordinateur d’opérations chirurgicales
A61M 37/00 - Autres appareils pour introduire des agents dans le corps; Percutanisation, c. à d. introduction de médicaments dans le corps par diffusion à travers la peau
A61N 5/10 - Radiothérapie; Traitement aux rayons gamma; Traitement par irradiation de particules
Systems and methods for treating target tissue include generating a priming sequence of sonication pulses for delivering acoustic energy to the target tissue; pausing generation of the sonication pulses for a delay interval; and generating a series of treatment sequences of sonication pulses for delivering acoustic energy to the target tissue, the treatment sequences having sonication intervals therebetween and the delay interval being larger than the largest sonication interval by a predetermined factor.
Embodiments of the present invention provide systems and methods to detect a moving anatomic feature during a treatment sequence based on a computed and/or a measured shortest distance between the anatomic feature and at least a portion of an imaging system.
A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiques; Mesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p.ex. formation d'images par résonance magnétique
A61B 6/12 - Dispositifs pour détecter ou localiser des corps étrangers
A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
A61B 8/08 - Détection de mouvements ou de changements organiques, p.ex. tumeurs, kystes, gonflements
A61B 6/00 - Appareils pour diagnostic par radiations, p.ex. combinés avec un équipement de thérapie par radiations
A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
G06T 7/70 - Détermination de la position ou de l'orientation des objets ou des caméras
G06T 7/32 - Détermination des paramètres de transformation pour l'alignement des images, c. à d. recalage des images utilisant des procédés basés sur la corrélation
G06T 3/00 - Transformation géométrique de l'image dans le plan de l'image
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p.ex. pour le traitement de la luxation ou pour la protection de bords de blessures
65.
ABERRATION CORRECTIONS FOR DYNAMICALLY CHANGING MEDIA DURING ULTRASOUND THERAPY
Various approaches to delivering ultrasound energy to a target region include, prior to delivery of the ultrasound energy, populating a data structure relating multiple real-time parameter values to corresponding correction values for one or more ultrasound parameter values associated with one or more transducer elements for generating a focal zone of acoustic energy in at least the first portion of the target region; and during the treatment, (i) predicting or causing measurement of at least one of the real-time parameter values in the second portion of the target region or the non-target region; (ii) based at least in part on the predicted or measured real-time parameter value(s) and contents of the data structure, determine the correction value(s) for the ultrasound parameter value(s); and (iii) activate the transducer element(s) based at least in part on the determined correction value(s) for the ultrasound parameter value(s) so as to generate the focal zone in the second portion of the target region.
A focused-ultrasound or other procedure for treating a target within a tissue region can be planned iteratively by creating a treatment plan specifying a treatment location pattern and stimuli applied thereto, simulating the treatment, computationally predicting an effect of the simulated treatment, comparing the predicted effect against one or more treatment constraints (such as efficacy and/or safety thresholds), and, if a constraint is violated, repeating the simulation for an adjusted treatment plan.
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p.ex. pour le traitement de la luxation ou pour la protection de bords de blessures
67.
Control of exogenous agent characteristics in microbubble-mediated ultrasound procedures
Various approaches for microbubble-enhanced ultrasound treatment of target tissue include retrieving a treatment plan stored in memory; causing administration of an exogenous agent in accordance with the treatment plan; causing, in accordance with the treatment plan, an ultrasound transducer to transmit ultrasound waves to the target tissue and generate a focus therein in the presence of administered exogenous agent; receiving, from a monitoring system, a measured parameter value indicating a treatment condition in response to administration of the exogenous agent and transmission of the ultrasound waves during treatment; and adjusting the treatment plan based at least in part on the measured parameter value.
A61M 37/00 - Autres appareils pour introduire des agents dans le corps; Percutanisation, c. à d. introduction de médicaments dans le corps par diffusion à travers la peau
11 +11 - field distribution in an MRI apparatus to improve the signal sensitivity and homogeneity at a region of interest. Approaches employed include strategic placement of field-altering features such as slots and/or dipoles along the exterior surface or, in some cases, the interior of the transducer. In various embodiments, the field-altering features are (or behave as) passive resonators.
A61B 90/14 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p.ex. pour le traitement de la luxation ou pour la protection de bords de blessures pour la chirurgie stéréotaxique, p.ex. système stéréotaxique à cadre - Détails de construction des fixateurs, p.ex. broches
Systems and methods provide accelerated MR thermometry utilizing prior knowledge about the images to be reconstructed from incomplete k-space data, thereby facilitating accurate reconstruction. In various embodiments, missing data is computationally estimated using a machine learning algorithm such as a neural network, and an image is generated based on iteratively updated estimated missing information.
G01R 33/56 - Amélioration ou correction de l'image, p.ex. par des techniques de soustraction ou d'établissement de moyenne
A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiques; Mesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p.ex. formation d'images par résonance magnétique
G01R 33/561 - Amélioration ou correction de l'image, p.ex. par des techniques de soustraction ou d'établissement de moyenne par réduction du temps de balayage, c.à d. systèmes d'acquisition rapide, p.ex. utilisant des séquences d'impulsions écho-planar
70.
Systems and methods for regulating microbubbles in ultrasound procedures
Various approaches for regulating microbubbles in a treatment procedure for a target include generating a tissue-sensitivity map including multiple regions, at least one of the regions being outside the target region, the tissue-sensitivity map assigning, to each of the regions, a sensitivity level indicative of tissue sensitivity to the interaction between the microbubbles and an acoustic beam; select one or more interaction regions based at least in part on the tissue-sensitivity map; and activating the ultrasound transducer so as to generate the acoustic beam for interacting with the microbubbles in the selection interaction region(s) in the tissue-sensitivity map, thereby indirectly changing a characteristic of the microbubbles at the target region.
Various approaches for regulating microbubbles in a treatment procedure for a target include generating a tissue-sensitivity map including multiple regions, at least one of the regions being outside the target region, the tissue-sensitivity map assigning, to each of the regions, a sensitivity level indicative of tissue sensitivity to the interaction between the microbubbles and an acoustic beam; select one or more interaction regions based at least in part on the tissue-sensitivity map; and activating the ultrasound transducer so as to generate the acoustic beam for interacting with the microbubbles in the selection interaction region(s) in the tissue-sensitivity map, thereby indirectly changing a characteristic of the microbubbles at the target region.
A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
A61B 8/08 - Détection de mouvements ou de changements organiques, p.ex. tumeurs, kystes, gonflements
A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiques; Mesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p.ex. formation d'images par résonance magnétique
Systems and methods for predicting a phase correction of ultrasound waves transmitted from one or more transducer elements and traversing a patient's skull into a target region utilizing data of the patient's skull include predicting a first beam path of the ultrasound waves traversing the skull based at least in part on the target location; computationally determining structural characteristics of the skull along the first beam path based on the acquired imaging data; and predicting a second beam path of the ultrasound waves traversing the skull based at least in part on the determined structural characteristics, thereby accounting for refraction resulting from the skull.
Various approaches for calibrating the geometry of an ultrasound transducer having multiple transducer elements include providing an acoustic reflector spanning an area traversing by multiple beam paths of ultrasound waves transmitted from all (or at least some) transducer elements to a focal zone; causing the transducer elements to transmit the ultrasound waves to the focal zone; measuring reflections of the ultrasound waves off the acoustic reflector; and based at least in part on the measured reflections, determining optimal geometric parameters associated with the transducer elements.
G01N 29/30 - Dispositions pour l'étalonnage ou la comparaison, p.ex. avec des objets standard
A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
G01S 7/52 - DÉTERMINATION DE LA DIRECTION PAR RADIO; RADIO-NAVIGATION; DÉTERMINATION DE LA DISTANCE OU DE LA VITESSE EN UTILISANT DES ONDES RADIO; LOCALISATION OU DÉTECTION DE LA PRÉSENCE EN UTILISANT LA RÉFLEXION OU LA RERADIATION D'ONDES RADIO; DISPOSITIONS ANALOGUES UTILISANT D'AUTRES ONDES - Détails des systèmes correspondant aux groupes , , de systèmes selon le groupe
G01F 1/66 - Mesure du débit volumétrique ou du débit massique d'un fluide ou d'un matériau solide fluent, dans laquelle le fluide passe à travers un compteur par un écoulement continu en mesurant la fréquence, le déphasage, le temps de propagation d'ondes électromagnétiques ou d'autres types d'ondes, p.ex. en utilisant des débitmètres à ultrasons
G01N 29/07 - Analyse de solides en mesurant la vitesse de propagation ou le temps de propagation des ondes acoustiques
A61B 8/08 - Détection de mouvements ou de changements organiques, p.ex. tumeurs, kystes, gonflements
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets
74.
Optimization of transducer configurations in ultrasound procedures
Various approaches to delivering ultrasound energy to a target region include an ultrasound transducer having multiple transducer elements for generating a focal zone of acoustic energy at the target region, wherein one or more transducer elements are partitioned into multiple contiguous sub-regions having a common directionality; one or more driver circuits connected to the transducer element(s); a switch matrix having multiple switches for switchably connecting the sub-regions to the driver circuit(s), each of the sub-regions being associated with one of the switches; and a controller configured to (i) determine an optimal sonication frequency for maximizing a peak acoustic intensity in the focal zone; and (ii) based at least in part on the determined optimal sonication frequency, activate one or more switches in the switch matrix for causing the corresponding sub-region(s) to transmit ultrasound pulses to the target region.
Various approaches to delivering ultrasound energy to a target region include an ultrasound transducer having multiple transducer elements for generating a focal zone of acoustic energy at the target region, wherein one or more transducer elements are partitioned into multiple contiguous sub-regions having a common directionality; one or more driver circuits connected to the transducer element(s); a switch matrix having multiple switches for switchably connecting the sub-regions to the driver circuit(s), each of the sub-regions being associated with one of the switches; and a controller configured to (i) determine an optimal sonication frequency for maximizing a peak acoustic intensity in the focal zone; and (ii) based at least in part on the determined optimal sonication frequency, activate one or more switches in the switch matrix for causing the corresponding sub-region(s) to transmit ultrasound pulses to the target region.
Various approaches for focusing an ultrasound transducer include introducing at least one transient acoustic reflector located in proximity to at least one target region; generating multiple sonications to the at least one target region; measuring a reflection signal of each of the sonications off the at least one transient acoustic reflector; selecting the measured reflection signals, and based at least in part on the selected reflection signals, adjusting a parameter value associated with at least one of the transducer elements so as to improve an ultrasound focus at the target region.
A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
G01S 7/52 - DÉTERMINATION DE LA DIRECTION PAR RADIO; RADIO-NAVIGATION; DÉTERMINATION DE LA DISTANCE OU DE LA VITESSE EN UTILISANT DES ONDES RADIO; LOCALISATION OU DÉTECTION DE LA PRÉSENCE EN UTILISANT LA RÉFLEXION OU LA RERADIATION D'ONDES RADIO; DISPOSITIONS ANALOGUES UTILISANT D'AUTRES ONDES - Détails des systèmes correspondant aux groupes , , de systèmes selon le groupe
A61B 8/08 - Détection de mouvements ou de changements organiques, p.ex. tumeurs, kystes, gonflements
G01S 15/89 - Systèmes sonar, spécialement adaptés à des applications spécifiques pour la cartographie ou la représentation
A system for maintaining coherence of ultrasound waves emitted by multiple transducer arrays includes multiple retention arms, each for receiving one of the transducer arrays; a connecting frame for receiving and mechanically retaining the arms in fixed angular relation to each other; and a processor configured to determine relative locations of the transducer arrays with respect to one another and the connecting frame; determine a location of the connecting frame relative to an anatomic region of interest; determine a spatial arrangement of the transducer elements in each transducer array with respect to the anatomic region of interest; and adjust a transmission configuration of the transducer elements in the transducer arrays to achieve a desired focusing property with respect to the anatomic region of interest while maintaining coherence therebetween.
A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiques; Mesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p.ex. formation d'images par résonance magnétique
A61B 34/20 - Systèmes de navigation chirurgicale; Dispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p.ex. pour la stéréotaxie sans cadre
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p.ex. pour le traitement de la luxation ou pour la protection de bords de blessures
A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
G10K 11/35 - Procédés ou dispositifs pour transmettre, conduire ou diriger le son pour focaliser ou pour diriger le son, p.ex. balayage utilisant la commande mécanique de transducteurs
Various approaches for computationally generating a protocol for treatment of one or more target BBB regions within a tissue region of interest using a source of focused ultrasound include specifying (i) settings of sonication parameters for applying one or more sequence of sonications to the target BBB region using the source of focused ultrasound and (ii) a characteristic of microbubbles selected to be administered into the target BBB region; electronically simulating treatment in accordance with the protocol at least in part by computationally executing the sequence(s) of sonications and computationally administering the microbubbles having the characteristic; and computationally predicting a tissue disruption effect of the target BBB region resulting from the treatment.
A61M 37/00 - Autres appareils pour introduire des agents dans le corps; Percutanisation, c. à d. introduction de médicaments dans le corps par diffusion à travers la peau
Systems and methods for performing magnetic resonance (MR) thermometry include a magnetic resonance imaging (MRI) unit (100) and a controller (124) in communication with the MRI unit (100) and configured to cause the MRI unit (100) to acquire one or more baseline phase images of an imaging region (110) and one or more treatment phase images of the imaging region (110) subsequent to a temperature change of a subregion within the imaging region (110), electronically generate a thermal map pixelwise indicating the temperature change of the subregion based at least in part on the acquired baseline phase image and treatment phase image, computationally predict the temperature change of the subregion based at least in part on energy deposited in the subregion during treatment without reference to the generated thermal map, and determine whether the thermal map is inaccurate based at least in part on the temperature change of the subregion indicated by the thermal map and the predicted temperature change of the subregion.
A61B 5/01 - Mesure de la température de parties du corps
A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiques; Mesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p.ex. formation d'images par résonance magnétique
80.
Systems and methods for correcting measurement artifacts in MR thermometry
Systems and methods for performing magnetic resonance (MR) thermometry include a magnetic resonance imaging (MRI) unit and a controller in communication with the MRI unit and configured to cause the MRI unit to acquire one or more baseline phase images of an imaging region and one or more treatment phase images of the imaging region subsequent to a temperature change of a subregion within the imaging region, electronically generate a thermal map pixelwise indicating the temperature change of the subregion based at least in part on the acquired baseline phase image and treatment phase image, computationally predict the temperature change of the subregion based at least in part on energy deposited in the subregion during treatment without reference to the generated thermal map, and determine whether the thermal map is inaccurate based at least in part on the temperature change of the subregion indicated by the thermal map and the predicted temperature change of the subregion.
Systems and methods for applying ultrasound sonication to temporarily disrupt a patient's blood-brain barrier (BBB) include storing threshold values of an acoustic response level, an acoustic response dose and a tissue response dose associated with a target BBB region and its surrounding regions based on anatomical characteristics thereof; causing the ultrasound transducer to transmit one or more pulses/waves; measuring the acoustic response level, the acoustic response dose, and/or the tissue response dose associated with the target BBB region and/or its surrounding regions; comparing the measurement with a corresponding stored threshold value; and operating the transducer based at least in part on the comparison.
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p.ex. pour le traitement de la luxation ou pour la protection de bords de blessures
82.
MEMS-switched ultrasonic transducer array with improved reliability
Various approaches for improving reliability in an ultrasound system having transducer elements, phase transmission lines, and a switch matrix having beamforming switches for connecting the phase transmission lines to the transducer elements involve operating the beamforming switches to avoid “hot” switching as the activation pattern of the transducers changes.
B06B 1/06 - Procédés ou appareils pour produire des vibrations mécaniques de fréquence infrasonore, sonore ou ultrasonore utilisant l'énergie électrique fonctionnant par effet piézo-électrique ou par électrostriction
B06B 1/02 - Procédés ou appareils pour produire des vibrations mécaniques de fréquence infrasonore, sonore ou ultrasonore utilisant l'énergie électrique
Various approaches for improving reliability in an ultrasound system having transducer elements, phase transmission lines, and a switch matrix having beamforming switches for connecting the phase transmission lines to the transducer elements involve operating the beamforming switches to avoid "hot" switching as the activation pattern of the transducers changes.
G01S 7/52 - DÉTERMINATION DE LA DIRECTION PAR RADIO; RADIO-NAVIGATION; DÉTERMINATION DE LA DISTANCE OU DE LA VITESSE EN UTILISANT DES ONDES RADIO; LOCALISATION OU DÉTECTION DE LA PRÉSENCE EN UTILISANT LA RÉFLEXION OU LA RERADIATION D'ONDES RADIO; DISPOSITIONS ANALOGUES UTILISANT D'AUTRES ONDES - Détails des systèmes correspondant aux groupes , , de systèmes selon le groupe
G01S 15/89 - Systèmes sonar, spécialement adaptés à des applications spécifiques pour la cartographie ou la représentation
G10K 11/34 - Procédés ou dispositifs pour transmettre, conduire ou diriger le son pour focaliser ou pour diriger le son, p.ex. balayage par commande électrique de systèmes de transducteurs, p.ex. en dirigeant un faisceau acoustique
84.
ULTRASOUND FOCUSING UTILIZING A 3D-PRINTED SKULL REPLICA
Various approaches to transmitting an ultrasound beam include creating a 3D tissue replica representing tissue intervening between the ultrasound transducer and a target anatomic region; transmitting a ultrasound beam to the target region; measuring the ultrasound beam traversing the 3D tissue replica and arriving at the target region; and based at least in part on the measured first ultrasound beam, estimating a parameter value associated with one or more of the transducer elements for improving ultrasound beam shaping.
Various approaches to stimulating neural activity in one or more target regions associated with one or more brain diseases or disorders include transmitting the first sequence of ultrasound pulses to the target region(s); measuring a physiological parameter indicative of the neural activity at the target region(s) resulting from the ultrasound pulses; and based at least in part on the measurement, adjusting a parameter value associated with one or more transducer elements so as to achieve a target objective of the neural activity.
Various approaches for focusing an ultrasound transducer having multiple transducer elements include causing the transducer elements to transmit ultrasound waves to a target region and measure reflections of the ultrasound waves off the target region; for each of at least some of the transducer elements, adjusting a parameter value associated with said each transducer element based at least in part on parameter values associated with multiple measuring transducer elements weighted by signal quality metrics associated with the reflections measured by the measuring transducer elements so as to improve an ultrasound focus at the target region.
Various approaches for generating an ultrasound focus at a target region and receiving signals therefrom using an ultrasound transducer having multiple transducer elements include acquiring multiple images of the target region and one or more path zones located on beam paths between the transducer elements and the target region; determining one or more tissue characteristics associated with the target region based on the acquired images; determining multiple profile parameters associated with each of the transducer elements based at least in part on the determined tissue characteristic; based at least in part on the profile parameters, operating at least first ones of the transducer elements to collectively transmit an ultrasound beam to the target region so as to create a focus thereon with desired properties; and based at least in part on the profile parameters, operating at least second ones of the transducer elements to receive acoustic signals from the target region and, in response thereto, adjusting operation of the at least first ones of the transducer elements to thereby improve the focus at the target region.
A61B 6/00 - Appareils pour diagnostic par radiations, p.ex. combinés avec un équipement de thérapie par radiations
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p.ex. pour le traitement de la luxation ou pour la protection de bords de blessures
During a magnetic resonance guided focused-ultrasound (MRgFUS) treatment or other non-invasive procedure, following an adaptive k- space sampling scheme only partial k-space image data are acquired and images of the target region are updated with partial image data encompassing only the regions of change. In one embodiment the image data correspond to MR thermometry or MR temperature imaging and serve tracking of various changing characteristics (e.g. position and/or temperature) such that in treatment procedure the therapeutic energy beam is guided onto the target and/or around other, non-target tissues and organs.
G01R 33/561 - Amélioration ou correction de l'image, p.ex. par des techniques de soustraction ou d'établissement de moyenne par réduction du temps de balayage, c.à d. systèmes d'acquisition rapide, p.ex. utilisant des séquences d'impulsions écho-planar
G01R 33/483 - Systèmes d'imagerie RMN avec sélection de signaux ou de spectres de régions particulières du volume, p.ex. spectroscopie in vivo
A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiques; Mesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p.ex. formation d'images par résonance magnétique
Skull inhomogeneity may be quantified in accordance with the skull density measured in skull images acquired using a conventional imager; the quantified inhomogeneity may then be used to determine whether the patient is suitable for ultrasound treatment and/or determine parameters associated with the ultrasound transducer for optimizing transskull ultrasound treatment.
Various approaches for operating an ultrasound transducer having multiple transducer elements include acquiring one or more measurements of anatomical regions through which ultrasound waves emitted from the transducer elements travel; for each of the anatomical regions, determining values of characteristics based at least in part on the measurement(s); computationally predicting aberrations of the ultrasound waves traveling through the anatomical regions by using the first values as input to a predictor that has been computationally trained to predict ultrasound aberrations based on values of the characteristics; and driving the transducer elements to compensate for the predicted aberrations.
A61B 8/08 - Détection de mouvements ou de changements organiques, p.ex. tumeurs, kystes, gonflements
A61B 6/00 - Appareils pour diagnostic par radiations, p.ex. combinés avec un équipement de thérapie par radiations
A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p.ex. pour le traitement de la luxation ou pour la protection de bords de blessures
Various approaches of focusing an ultrasound transducer having multiple transducer elements to a target region include generating at least one acoustic reflector in the target region; transmitting ultrasound waves to the acoustic reflector; measuring reflections off the acoustic reflector; and based at least in part on the measured reflections, adjusting the parameter value associated with the transducer element(s).
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets
A61B 17/22 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets pour l'élimination non prévue ailleurs des obstructions dans les vaisseaux sanguins
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p.ex. pour le traitement de la luxation ou pour la protection de bords de blessures
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
Computer software for controlling and operating image-guided
focussed ultrasound systems, and user manuals sold as a unit
therewith. Image-guided focussed ultrasound diagnostic apparatus for
therapeutic and diagnostic medical procedures, and user
manuals sold as a unit therewith.
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
Computer software for use in image-guided focussed
ultrasound systems, and user manuals sold as a unit
therewith. Image-guided focussed ultrasound diagnostic apparatus for
therapeutic and diagnostic medical procedures, and user
manuals sold as a unit therewith.
Treatment of target tissue in a target volume having multiple target regions includes causing an ultrasound transducer to transmit a first series of ultrasound waves having a first frequency to a first one of target regions; and causing the ultrasound transducer to transmit a second series of ultrasound waves having a second frequency, different from the first frequency, to a second one of the target regions, different from the first one of the target regions, based on one or more different anatomical characteristics (such as focal lengths) between the first and second ones of the target regions.
Various approaches for calibrating the geometry of an ultrasound transducer having multiple transducer elements include providing an acoustic reflector spanning an area traversing by multiple beam paths of ultrasound waves transmitted from all (or at least some) transducer elements to a focal zone; causing the transducer elements to transmit the ultrasound waves to the focal zone; measuring reflections of the ultrasound waves off the acoustic reflector; and based at least in part on the measured reflections, determining optimal geometric parameters associated with the transducer elements.
Various approaches to generating and maintaining an ultrasound focus at a target region include configuring a controller to cause transmission of treatment ultrasound pulses from a transducer having multiple transducer elements; cause the transducer to transmit focusing ultrasound pulses to the target region and generate an acoustic reflector therein; measure reflections of the focusing ultrasound pulses from the acoustic reflector; based at least in part on the measured reflections, adjust a parameter value associated with one or more transducer elements so as to maintain and/or improve the ultrasound focus at the target region.
A61B 8/08 - Détection de mouvements ou de changements organiques, p.ex. tumeurs, kystes, gonflements
A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiques; Mesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p.ex. formation d'images par résonance magnétique
G01S 7/52 - DÉTERMINATION DE LA DIRECTION PAR RADIO; RADIO-NAVIGATION; DÉTERMINATION DE LA DISTANCE OU DE LA VITESSE EN UTILISANT DES ONDES RADIO; LOCALISATION OU DÉTECTION DE LA PRÉSENCE EN UTILISANT LA RÉFLEXION OU LA RERADIATION D'ONDES RADIO; DISPOSITIONS ANALOGUES UTILISANT D'AUTRES ONDES - Détails des systèmes correspondant aux groupes , , de systèmes selon le groupe
A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
Various approaches to focusing an ultrasound transducer includes causing the ultrasound transducer to transmit ultrasound waves to the target region; causing the detection system to indirectly measure the focusing properties; and based at least in part on the indirectly measured focusing properties, adjusting a parameter value associated with at least one of the transducer elements so as to achieve a target treatment power at the target region.
Various approaches for microbubble-enhanced ultrasound treatment of target tissue include receiving a desired characteristic of the microbubbles for treating the target tissue; causing the microbubbles to be dispensed from the administration device; and comparing a characteristic of the dispensed microbubbles to the desired characteristic so as to validate a match therebetween.
A61M 37/00 - Autres appareils pour introduire des agents dans le corps; Percutanisation, c. à d. introduction de médicaments dans le corps par diffusion à travers la peau
A61K 49/22 - Préparations pour échographie; Préparations pour imagerie par ultrasons
A61B 34/10 - Planification, simulation ou modélisation assistées par ordinateur d’opérations chirurgicales
A61K 41/00 - Préparations médicinales obtenues par traitement de substances par énergie ondulatoire ou par rayonnement corpusculaire
A61B 8/08 - Détection de mouvements ou de changements organiques, p.ex. tumeurs, kystes, gonflements
99.
CONTROL OF EXOGENOUS AGENT CHARACTERISTICS IN MICROBUBBLE-MEDIATED ULTRASOUND PROCEDURES
Various approaches for microbubble-enhanced ultrasound treatment of target tissue include retrieving a treatment plan stored in memory; causing administration of an exogenous agent in accordance with the treatment plan; causing, in accordance with the treatment plan, an ultrasound transducer to transmit ultrasound waves to the target tissue and generate a focus therein in the presence of administered exogenous agent; receiving, from a monitoring system, a measured parameter value indicating a treatment condition in response to administration of the exogenous agent and transmission of the ultrasound waves during treatment; and adjusting the treatment plan based at least in part on the measured parameter value.
Various approaches to generating and maintaining an ultrasound focus at a target region include configuring a controller to cause transmission of treatment ultrasound pulses from a transducer having multiple transducer elements; cause the transducer to transmit focusing ultrasound pulses to the target region and generate an acoustic reflector therein; measure reflections of the focusing ultrasound pulses from the acoustic reflector; based at least in part on the measured reflections, adjust a parameter value associated with one or more transducer elements so as to maintain and/or improve the ultrasound focus at the target region.
A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
A61B 8/08 - Détection de mouvements ou de changements organiques, p.ex. tumeurs, kystes, gonflements
G01S 15/89 - Systèmes sonar, spécialement adaptés à des applications spécifiques pour la cartographie ou la représentation
G01S 7/52 - DÉTERMINATION DE LA DIRECTION PAR RADIO; RADIO-NAVIGATION; DÉTERMINATION DE LA DISTANCE OU DE LA VITESSE EN UTILISANT DES ONDES RADIO; LOCALISATION OU DÉTECTION DE LA PRÉSENCE EN UTILISANT LA RÉFLEXION OU LA RERADIATION D'ONDES RADIO; DISPOSITIONS ANALOGUES UTILISANT D'AUTRES ONDES - Détails des systèmes correspondant aux groupes , , de systèmes selon le groupe
A61B 5/01 - Mesure de la température de parties du corps
A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiques; Mesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p.ex. formation d'images par résonance magnétique
A61B 17/22 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets pour l'élimination non prévue ailleurs des obstructions dans les vaisseaux sanguins
A61B 34/10 - Planification, simulation ou modélisation assistées par ordinateur d’opérations chirurgicales
