CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (France)
INSTITUT FRANCAIS DE RECHERCHE POUR L EXPLOITATION DE LA MER (France)
Inventeur(s)
Breton, Gildas
Larvol, Lionel
Harrault, Loïc
Soudant, Philippe
Le Grand, Fabienne
Corvaisier, Rudolph
Abrégé
The present invention relates to a method for authenticating and detecting adulteration of an oil of marine origin, characterised in that the method comprises: obtaining molecular data including: - determining the fatty acid and/or unsaponifiable compound composition of said oil; obtaining isotopic data including: - determining the ratio of the stable isotopes of carbon (13C/12C) of fatty acids and/or of unsaponifiables, - obtaining a profile of said oil on the basis of the data, - comparing the profile obtained with reference profiles of oils of determined marine origin, - concluding that the oil to be identified has a profile substantially identical to one of the reference profiles and therefore indicating the origin, if, at the end of the comparison, the profile corresponds to a recorded profile and, otherwise, concluding that the oil is a mixture or of different origin than a pure fish oil or a pure microorganism oil, and estimating the proportions of this mixture.
A61K 35/56 - Substances provenant d’animaux autres que les mammifères
A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
A61P 31/14 - Antiviraux pour le traitement des virus ARN
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
A61K 35/64 - Insectes, p. ex. abeilles, guêpes ou puces
A61K 39/39 - Préparations médicinales contenant des antigènes ou des anticorps caractérisées par les additifs immunostimulants, p. ex. par les adjuvants chimiques
3.
DISUBSTITUTED FERROCENE COMPOUNDS AND THEIR THERAPEUTIC USE
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
CENTRE DE COOPÉRATION INTERNATIONALE EN RECHERCHE AGRONOMIQUE POUR LE DÉVELOPPEMENT (France)
Inventeur(s)
Nouvel, Philippe
Louche, Hervé
Coillot, Christophe
Clair, Bruno
Do, Frédéric
Plagellat-Penarier, Annick
Abrégé
The invention relates to a portable apparatus (100) for measuring at least one flow of sap in a plant, the plant having an outer casing, the apparatus (100) comprising: - a microwave emitter (10) for emitting a microwave electromagnetic flux towards a first portion of the outer casing of the plant so as to heat an inner portion of the plant; - a thermal sensor (20) arranged to capture thermal radiation from the plant over time; - a processing unit (30) configured to determine, from the thermal radiation captured by the thermal sensor, a movement of the heat front over time in the plant and to estimate, on the basis of the movement of the heat front, the flow of sap.
G01F 1/58 - Mesure du débit volumétrique ou du débit massique d'un fluide ou d'un matériau solide fluent, dans laquelle le fluide passe à travers un compteur par un écoulement continu en utilisant des effets électriques ou magnétiques par débitmètres électromagnétiques
G01F 1/68 - Mesure du débit volumétrique ou du débit massique d'un fluide ou d'un matériau solide fluent, dans laquelle le fluide passe à travers un compteur par un écoulement continu en utilisant des effets thermiques
G01F 1/704 - Mesure du débit volumétrique ou du débit massique d'un fluide ou d'un matériau solide fluent, dans laquelle le fluide passe à travers un compteur par un écoulement continu utilisant des zones marquées ou non homogènes de l’écoulement de fluide, p. ex. des variations statistiques d'un paramètre du fluide
C07K 14/195 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries
A23L 33/135 - Bactéries ou leurs dérivés, p. ex. probiotiques
A61K 8/99 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des produits de constitution indéterminée ou leurs dérivés à base de micro-organismes autres que des algues ou des champignons, p. ex. à base de protozoaires ou de bactéries
C12N 15/74 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes procaryotes autres que E. coli, p. ex. Lactobacillus, Micromonospora
C12P 1/04 - Préparation de composés ou de compositions, non prévue dans les groupes , utilisant des micro-organismes ou des enzymesProcédés généraux de préparation de composés ou de compositions utilisant des micro-organismes ou des enzymes utilisant des bactéries
C12Q 1/02 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des micro-organismes viables
C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique
C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
6.
BUTYROPHILIN (BTN) 3A ACTIVATING ANTIBODIES FOR USE IN METHODS FOR TREATING INFECTIOUS DISORDERS
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) (France)
UNIVERSITÉ D'AIX-MARSEILLE (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
INSTITUT JEAN PAOLI & IRENE CALMETTES (France)
ASSISTANCE PUBLIQUE HOPITAUX DE MARSEILLE (France)
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (France)
Inventeur(s)
Olive, Daniel
Mezouar, Soraya
Mege, Jean-Louis
Frohna, Paul
Truneh, Alemseged
Gay, Laetitia
Abrégé
The present disclosure relates to methods for treating infectious disorders. In particular, the disclosure provides BTN3A activating antibodies, and their use in treating infectious disorders in a human subject in need thereof, such as disorders caused by SARS-Cov2 or Coxiella burnetii infection.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (France)
INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM) (France)
Inventeur(s)
Extramiana, Fabrice
Prifti, Edi
Fall, Ahmad
Salem, Joe-Elie
Denjoy, Isabelle
Zucker, Jean-Daniel
Leenhardt, Antoine
Abrégé
The invention relates to the detection of the risk for a patient with a congenital Long QT (LQT) condition for having a torsades-de-pointes event, and the mechanisms underlying such risk, in particular via the use of neural networks.
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (France)
UNIVERSITE DE LA REUNION (France)
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (France)
Inventeur(s)
Apel, Cécile
Roussi, Fanny
El Kalamouni, Chaker
Litaudon, Marc
Haddad, Juliano
Desrat, Sandy
Abrégé
The present invention relates to a compound of the formula (I): (I). The present invention further relates to the process for extracting it, to the medicament or pharmaceutical composition containing it and to its use in therapy, in particular in the prevention and/or treatment of cancer and virus infections.
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
CPE LYON (France)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (France)
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (France)
UNIVERSITE CLAUDE BERNARD LYON 1 (France)
UNIVERSITE DE LA REUNION (France)
TROPICAL BIOCONTROL (France)
Inventeur(s)
Andrianjafy, Mbolatiana Tovo
Vestalys, Voahangy
Lemaire, Marc
Mavingui, Patrick
Ramiharimanana, Fenia Diane
Lamare, Saholy
Abrégé
Disclosed is the use of a compound with the following formula (I):
Disclosed is the use of a compound with the following formula (I):
Disclosed is the use of a compound with the following formula (I):
R is a linear or branched alkyl group including from 2 to 20 carbon atoms, the compound being in the form of a racemic mixture, an enantiomer (R) or an enantiomer (S), as an attractant or repellent for blood-sucking, biting invertebrates.
A01N 43/16 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un ou plusieurs atomes d'oxygène ou de soufre comme uniques hétéro-atomes du cycle avec un hétéro-atome des cycles à six chaînons avec l'oxygène comme hétéro-atome du cycle
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (IRD) (France)
HYPERTHERMICS AS (Norvège)
Inventeur(s)
Erauso, Gaël
Combet-Blanc, Yannick
Davidson, Sylvain
Prime, Anne-Hélène
Strick, Maximilian
Miller, Stefan
Nordal, Harald
Abrégé
The present invention relates to new thermophilic anaerobic bacteria strains to produce hydrogen gas in acidic conditions and a method for producing hydrogen by culturing these thermophilic bacteria strains.
METHOD FOR MEASURING THE OXIDATION POTENTIAL OF SAMPLES, IN PARTICULAR AEROSOLS, EQUIPMENT FOR THE IMPLEMENTION THEREOF AND USE OF SAME FOR ON-LINE ANALYSIS OF AIR QUALITY
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
INSTITUT POLYTECHNIQUE DE GRENOBLE (France)
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (France)
UNIVERSITE GRENOBLE ALPES (France)
Inventeur(s)
Uzu, Gaëlle
Jaffrezo, Jean-Luc
Freche, Guilhem
Abrégé
The present application relates to a method for the on-line and real-time automatic determination of the oxidization potential of an environment, enabling the air quality and/or the toxicity of the vapors emitted by various appliances or facilities to be analyzed.
The present application relates to a method for the on-line and real-time automatic determination of the oxidization potential of an environment, enabling the air quality and/or the toxicity of the vapors emitted by various appliances or facilities to be analyzed.
Figure for the abstract: None
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Education; training; entertainment; sporting and cultural
activities; information with respect to entertainment;
information with respect to education; vocational
retraining; tutoring; organization and conducting of
workshops [training]; book publishing and lending of books,
magazines and teaching material; electronic publishing of
books, periodicals and teaching material online; providing
non-downloadable films via video-on-demand services; news
reporter services; production of motion pictures, of videos;
photography services; organization of competitions
(education or entertainment); organization and conducting of
colloquiums; organization and conducting of conferences;
organization and conducting of congresses; organization of
exhibitions for cultural or educational purposes; electronic
publication of books and journals online. Technical evaluations concerning design (engineers'
services); scientific research; research in natural sciences
and in earth sciences; technical research; conducting of
technical project studies; quality control; scientific and
technical expertise; design of computers for third parties;
computer development; design, development and implementation
of software; computer system analysis; computer system
design; consultant services with respect to computer
hardware design and development; digitization of documents;
Software as a Service (SaaS); advice regarding information
technology; server hosting; energy auditing; electronic data
storage; research and development of new products for third
parties.
13.
METHODS FOR THE TREATMENT OF CORONAVIRUS INFECTIONS
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (France)
UNIVERSITÉ D'AIX MARSEILLE (France)
ASSISTANCE PUBLIQUE HÔPITAUX DE MARSEILLE (France)
ECOLE NORMALE SUPÉRIEURE DE LYON (France)
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (France)
UNIVERSITÉ CLAUDE BERNARD - LYON 1 (France)
Inventeur(s)
Vidalain, Pierre-Olivier
Nougairede, Antoine
Touret, Franck
Andre, Patrice
Lotteau, Vincent
Lamballerie, Xavier Nicolas
Janin, Yves Louis
Abrégé
Coronaviridae is a family of enveloped, positive-sense, single-stranded RNA viruses. The emergence of a new beta-coronavirus SARS-CoV-2 has led to a major health-related crisis associated with a significant mortality in intensive care units, due to the pulmonary complications of COVID-19. The inventors showed that BAY-2402234 is suitable for inhibiting replication of coronavirus and thus would be suitable for the treatment of infections mediated by said type of virus.
INSERM (Institut National de la Santé et de la Recherche Médicale) (France)
UNIVERSITÉ D'AIX MARSEILLE (France)
ASSISTANCE PUBLIQUE HÔPITAUX DE MARSEILLE (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (France)
ECOLE NORMALE SUPÉRIEURE DE LYON (France)
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (IRD) (France)
UNIVERSITÉ CLAUDE BERNARD - LYON 1 (France)
Inventeur(s)
Vidalain, Pierre-Olivier
Lotteau, Vincent
Andre, Patrice
Touret, Franck
De Lamballerie, Xavier Nicolas
Nougairede, Antoine
Abrégé
Coronaviridae is a family of enveloped, positive-sense, single-stranded RNA viruses. The emergence of a new betacoronavirus SARS-CoV-2 has led to a major health-related crisis associated with a significant mortality in intensive care units, due to the pulmonary complications of COVID-19. The inventors showed that Vidofludimus is suitable for inhibiting replication of coronavirus and thus would be suitable for the treatment of infections mediated by said type of virus.
A61K 31/196 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe amino le groupe amino étant lié directement à un cycle, p. ex. acide anthranilique, acide méfénamique, diclofénac, chlorambucil
A61P 31/14 - Antiviraux pour le traitement des virus ARN
A61K 31/53 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec trois azote comme seuls hétéro-atomes d'un cycle, p. ex. chlorazanil, mélamine
15.
BUTYROPHILIN (BTN) 3A ACTIVATING ANTIBODIES FOR USE IN METHODS FOR TREATING INFECTIOUS DISORDERS
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) (France)
UNIVERSITÉ D'AIX-MARSEILLE (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
INSTITUT JEAN PAOLI & IRENE CALMETTES (France)
ASSISTANCE PUBLIQUE HOPITAUX DE MARSEILLE (France)
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (IRD) (France)
Inventeur(s)
Olive, Daniel
Mezouar, Soraya
Mege, Jean-Louis
Frohna, Paul
Truneh, Alemseged
Gay, Laetitia
Abrégé
The present disclosure relates to methods for treating infectious disorders. In particular, the disclosure provides BTN3A activating antibodies, and their use in treating infectious disorders in a human subject in need thereof, such as disorders caused by SARS-Cov2 or Coxiella burnetii infection.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (France)
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (IRD) (France)
UNIVERSITE DE LA REUNION (La Reunion)
TORSKAL (La Reunion)
Inventeur(s)
Despres, Philippe
Gadea, Gilles
Viranaicken, Wildriss
Andries, Jessica
Morel, Anne-Laure
Ben Haddada, Maroua
Abrégé
616-6441138-11691138-1169616-644616-6441138-1169616-6441138-11691138-1169 have ability to react as antibody epitopes in relation to a BNT162b2 recipient serum and thus can be used for diagnostic and vaccine purposes.
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (France)
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (IRD) (France)
INSTITUT POLYTECHNIQUE DE BORDEAUX (France)
ABYSS INGREDIENTS (France)
INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER - IFREMER (France)
INSTITUT NATIONAL DE LA RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT (France)
Inventeur(s)
Guerard, Fabienne
Oroy, Cloé
Lepoudere, Anne
Chataigner, Mathilde
Allaume, Patrick
Dinel, Anne-Laure
Joffre, Corinne
Pallet, Véronique
Le Grand, Fabienne
Abrégé
A protein hydrolysate obtained from at least one protein source from bluefish having (i) a degree of hydrolysis (DH) of at least 10%, (ii) at least 80% water-soluble protein with a molecular weight of less than 1000 Da, (iii) at least 0.3% phospholipids, and (iv) at least 0.5% DHA and EPA.
A23J 1/04 - Préparation des compositions à base de protéines pour l'alimentationOuverture des œufs par grandes quantités et séparation du jaune du blanc à partir du poisson ou d'autres animaux marins
A61K 31/202 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe carboxyle lié à une chaîne acyclique d'au moins sept atomes de carbone, p. ex. acides stéarique, palmitique ou arachidique ayant au moins trois doubles liaisons, p. ex. acide linolénique
A61K 35/60 - Poissons, p. ex. hippocampesŒufs de poisson
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
CPE LYON (France)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (France)
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (France)
UNIVERSITE CLAUDE BERNARD LYON 1 (France)
UNIVERSITE DE LA REUNION (France)
TROPICAL BIOCONTROL (France)
Inventeur(s)
Andrianjafy, Mbolatiana Tovo
Vestalys, Voahangy
Lemaire, Marc
Mavingui, Patrick
Ramiharimanana, Fenia Diane
Lamare, Saholy
Abrégé
The present invention relates to the use of a compound of formula (I) where R represents a linear or branched alkyl group comprising from 2 to 20 carbon atoms, said compound being in the form of a racemic mixture, of an enantiomer (R) or an enantiomer (S), as an attractant or repellent for blood-sucking, biting invertebrates.
A01N 43/16 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un ou plusieurs atomes d'oxygène ou de soufre comme uniques hétéro-atomes du cycle avec un hétéro-atome des cycles à six chaînons avec l'oxygène comme hétéro-atome du cycle
INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM) (France)
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (France)
SORBONNE UNIVERSITÉ (France)
Inventeur(s)
Salem, Joe-Elie
Prifti, Edi
Pulini, Alfredo Aram
Zucker, Jean-Daniel
Funck-Brentano, Christian
Leenhardt, Antoine
Denjoy, Isabelle
Extramiana, Fabrice
Abrégé
The invention relates to methods and devices for the detection and prediction of the risk for a patient to have a torsade de pointe event, and causes thereof, in particular via the use of neural networks.
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
20.
N-HETEROCYCLIC CARBENE LIGANDS AND USE THEREOF AS THERAPEUTIC AGENTS
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
UNIVERSITE PAUL SABATIER TOULOUSE III (France)
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (France)
Inventeur(s)
Gornitzka, Heinz
Valentin, Alexis
Bourgeade-Delmas, Sandra
Hemmert, Catherine
Abrégé
The present invention relates to a complex of cationic or neutral gold (I) with fluorinated NHC ligands, as well as the uses thereof as an anti-oxidant, anti-cancer, anti-bacterial and/or anti-parasitic agent and, in particular, an anti-leishmanial agent.
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (France)
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (IRD) (France)
UNIVERSITE DE LA REUNION SAINT DENIS (La Reunion)
Inventeur(s)
Despres, Philippe
Gadea, Gilles
Vanwalscappel, Bénédicte
Abrégé
ZikaApoptosis M PeptideApoptosis M Peptide) (SEQ ID NO:l) to confer pro-apoptotic activity to a tumor-associated antigen such as MPF opens up new attractive perspectives for ZAMP as innovative anti-cancer agent.
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
METHOD FOR MEASURING THE OXIDATION POTENTIAL OF SAMPLES, IN PARTICULAR AEROSOLS, EQUIPMENT FOR THE IMPLEMENTION THEREOF AND USE OF SAME FOR ON-LINE ANALYSIS OF AIR QUALITY
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
INSTITUT POLYTECHNIQUE DE GRENOBLE (France)
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (France)
UNIVERSITE GRENOBLE ALPES (France)
Inventeur(s)
Uzu, Gaëlle
Jaffrezo, Jean-Luc
Freche, Guilhem
Abrégé
The present application relates to a method for the on-line and real-time automatic determination of the oxidization potential of a medium, enabling the air quality and/or the toxicity of the vapors emitted by various appliances or facilities to be analyzed.
G01N 33/84 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des composés inorganiques ou le pH
09 - Appareils et instruments scientifiques et électriques
38 - Services de télécommunications
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Scientific measuring apparatus and instruments; connected
environmental-measurement station particularly for measuring
air quality, humidity levels and temperature; air analysis
apparatus; hygrometers; thermo-hygrometers; meteorological
instruments; digital weather stations; air quality
micro-sensor; humidity micro-sensor; temperature
micro-sensor; environmental measurement micro-sensors;
apparatus and instruments for data recording, transmission,
reproduction or processing; software [recorded programs] for
use in environmental-measurement stations; downloadable
electronic publications. Providing access to databases; data dissemination and
transmission services by electronic means. Education; training; organization and conducting of training
workshops; organization and conducting of conferences;
practical training [demonstration]; organization and
conducting of non-virtual educational forums; providing
information with respect to education; publication of texts
other than advertising texts; online publication of
specialized electronic journals; providing non-downloadable
electronic publications online. Scientific and technological services as well as research
and design services relating thereto; conducting of
technical project studies; surveying [engineering work];
providing software for collecting data concerning air
quality; air quality assessment, monitoring and analysis
services; research and providing scientific information in
the field of climate change; computer platform as a service
[PaaS].
24.
USE OF CARNOSOL FOR INCREASING MUSCLE PROTEIN SYNTHESIS
Centre National De La Recherche Scientifique (France)
Universite De Montpellier (France)
Institut National De La Sante Et De La Recherche Medicale (INSERM) (France)
Universite Paul-Valery Montpellier 3 (France)
Ecole Pratique Des Hautes Etudes (EPHE) (France)
Institut De Recherche Pour Le Developpement (France)
Inventeur(s)
Carnac, Gilles
Saint, Nathalie
Morel, Sylvie
Rapior, Sylvie
Vitou, Manon
Abrégé
The present invention relates to the use of carnosol or of a composition comprising carnosol for increasing muscle protein synthesis and/or for reducing the muscle protein degradation in a subject.
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (France)
UNIVERSITÉ D'AIX MARSEILLE (France)
ASSISTANCE PUBLIQUE HÔPITAUX DE MARSEILLE (France)
ECOLE NORMALE SUPÉRIEURE DE LYON (France)
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (IRD) (France)
UNIVERSITÉ CLAUDE BERNARD - LYON 1 (France)
Inventeur(s)
Vidalain, Pierre-Olivier
Nougairede, Antoine
Touret, Franck
Andre, Patrice
Lotteau, Vincent
De Lamballerie, Xavier Nicolas
Janin, Yves Louis
Abrégé
CoronaviridaeCoronaviridae is a family of enveloped, positive-sense, single-stranded RNA viruses. The emergence of a new betacoronavirus SARS-CoV-2 has led to a major health-related crisis associated with a significant mortality in intensive care units, due to the pulmonary complications of COVID-19. The inventors showed that BAY-2402234 is suitable for inhibiting replication of coronavirus and thus would be suitable for the treatment of infections mediated by said type of virus.
A61K 31/427 - Thiazoles non condensés et contenant d'autres hétérocycles
A61K 31/4706 - 4-Aminoquinoléines8-Aminoquinoléines, p. ex. chloroquine, primaquine
A61K 31/513 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime ayant des groupes oxo liés directement à l'hétérocycle, p. ex. cytosine
A61K 31/706 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p. ex. nucléosides, nucléotides contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
A61P 31/14 - Antiviraux pour le traitement des virus ARN
A61K 31/685 - Diesters d'acide du phosphore avec deux composés hydroxyle, p. ex. phosphatidylinositols un des composés hydroxylés ayant des atomes d'azote, p. ex. phosphatidylsérine, lécithine
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) (France)
UNIVERSITÉ D'AIX MARSEILLE (France)
ASSISTANCE PUBLIQUE HÔPITAUX DE MARSEILLE (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (France)
ECOLE NORMALE SUPÉRIEURE DE LYON (France)
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (IRD) (France)
UNIVERSITÉ CLAUDE BERNARD - LYON 1 (France)
Inventeur(s)
Vidalain, Pierre-Olivier
Lotteau, Vincent
Andre, Patrice
Touret, Franck
De Lamballerie, Xavier Nicolas
Nougairede, Antoine
Abrégé
CoronaviridaeCoronaviridae is a family of enveloped, positive-sense, single-stranded RNA viruses. The emergence of a new betacoronavirus SARS-CoV-2 has led to a major health-related crisis associated with a significant mortality in intensive care units, due to the pulmonary complications of COVID-19. The inventors showed that Vidofludimus is suitable for inhibiting replication of coronavirus and thus would be suitable for the treatment of infections mediated by said type of virus.
A61K 31/192 - Acides carboxyliques, p. ex. acide valproïque ayant des groupes aromatiques, p. ex. sulindac, acides 2-aryl-propioniques, acide éthacrynique
A61P 31/20 - Antiviraux pour le traitement des virus ADN
27.
AEROSOLIZATION OF HDL FOR THE TREATMENT OF LUNG INFECTIONS
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (France)
UNIVERSITE DE LA REUNION SAINT DENIS (France)
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (IRD) (France)
Inventeur(s)
Meilhac, Olivier
Mavingui, Patrick
Lambert, Gilles
Abrégé
Lung infections remain a substantial concern, even in wealthy countries. For instance, the emergence of a new betacoronavirus SARS-CoV-2 has led to a major health-related crisis associated with a significant mortality in intensive care units, due to the pulmonary complications of COVID-19. The inventors aim at developing a new therapeutic approach based on the local delivery of apolipoprotein A1 nanoparticles into the lung by aerosolization. These particles may display antiviral properties that could be improved by loading them with small interference RNAs specifically targeting SARS-CoV2 genome and antiviral drugs (such as the hydrophobic chloroquine). Their preliminary results have shown in preclinical mouse models that aerosolization allowed apoA1 nanoparticle uptake and persistence (up to 72h) in pulmonary cells. In addition to the potential intrinsic antiviral activity of apoA1, these particle display important anti-inflammatory effects that may limit the excessive immuno-inflammatory host response that is deleterious for the lung. Thus, the present invention relates to aerosolization of HDL for the treatment of lung infections.
A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
A61K 31/661 - Acides du phosphore ou leurs esters n'ayant pas de liaison P-C, p. ex. fosfosal, dichlorvos, malathion
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) (France)
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (IRD) (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (France)
UNIVERSITE DE LA REUNION SAINT DENIS (La Reunion)
Inventeur(s)
Despres, Philippe
Viranaicken, Wildriss
Frumence, Etienne
Gadea, Gilles
Abrégé
The present invention relates to the field of vaccination against flaviviruses, and in particular against Zika virus. The invention further relates to methods for producing or selecting antibodies directed against said flaviviruses. The invention further relates to isolated polypeptides, recombinant cells, and attenuated viruses, suitable for eliciting an immune response. The inventors have shown that a 20-mer peptide GSQHSGMTVNDIGYETDENR representing the glycan-loop (GL) of the Zika virus (ZIKV) strain MR766 is antigenic in a peptide-based ELISA format. To the knowledge of the inventors, this is the first report demonstrating the antigenicity of a fragment of the Envelope protein of a flavivirus, within Domain I (E-DI), which explicitly includes the glycan-loop itself.
A61Q 19/08 - Préparations contre le vieillissement
A61K 8/35 - Cétones, p. ex. quinones, benzophénone
A61K 31/352 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à six chaînons avec un oxygène comme seul hétéro-atome d'un cycle condensés avec des carbocycles, p. ex. cannabinols, méthanthéline
A61P 17/00 - Médicaments pour le traitement des troubles dermatologiques
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (France)
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (IRD) (France)
INSTITUT POLYTECHNIQUE DE BORDEAUX (France)
ABYSS INGREDIENTS (France)
INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER - IFREMER (France)
INSTITUT NATIONAL DE RECHERCHE POUR L’AGRICULTURE, L’ALIMENTATION ET L’ENVIRONNEMENT (France)
Inventeur(s)
Guerard, Fabienne
Oroy, Cloé
Lepoudere, Anne
Chataigner, Mathilde
Allaume, Patrick
Dinel, Anne-Laure
Joffre, Corinne
Pallet, Véronique
Le Grand, Fabienne
Abrégé
The invention relates to a protein hydrolysate which is obtained from at least one protein source derived from blue-backed fish and which comprises (i) a degree of hydrolysis (DH) of at least 10%, (ii) at least 80% water-soluble proteins having a molecular weight of less than 1000 Da, (iii) at least 0.3% phospholipids, and (iv) at least 0.5% DHA and EPA.
A61K 31/202 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe carboxyle lié à une chaîne acyclique d'au moins sept atomes de carbone, p. ex. acides stéarique, palmitique ou arachidique ayant au moins trois doubles liaisons, p. ex. acide linolénique
INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM) (France)
UNIVERSITÉ DE PARIS (France)
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (France)
SORBONNE UNIVERSITÉ (France)
Inventeur(s)
Salem, Joe-Elie
Prifti, Edi
Pulini, Alfredo Aram
Zucker, Jean-Daniel
Funck-Brentano, Christian
Leenhardt, Antoine
Denjoy, Isabelle
Extramiana, Fabrice
Abrégé
The invention relates to methods and devices for the detection and prediction of the risk for a patient to have a torsade de pointe event, and causes thereof, in particular via the use of neural networks.
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
Centre National de la Recherche Scientifique (CNRS) (USA)
Ecole Nationale Superieure de Chimie (USA)
Institut de Recherche Pour le Developpement (IRD) (USA)
Universite D'Aix-Marseille (USA)
Université Côte d'Azur (USA)
Inventeur(s)
Crauste, Céline
Vercauteren, Joseph
Veas, Francisco
Durand, Thierry
Blondeau, Nicolas
Abrégé
The present invention relates to compound of formula (I):
3 or
for use in prevention and/or treatment of a disease or disorder linked to an exacerbated vascular, lymphatic or mucosal permeability.
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
INSTITUT POLYTECHNIQUE DE GRENOBLE (France)
Inventeur(s)
Biron, Romain
Rabatel, Antoine
Abrégé
The invention relates to the field of glaciology and more particularly to a device (1) for measuring the surface melting of a glacier, comprising: - a measurement module for measuring the surface melting of the glacier; - a remote transmission system; - a support; and - a battery; characterized in that the measurement module comprises a cable (110), a winder capable of winding the cable (110) so as to keep said cable taut, an encoder wheel configured so as to be rotated when the cable is wound by the winder; the winder and the encoder wheel being arranged such that the surface melting of the glacier causes the cable to be wound by the winder and the encoder wheel to rotate correspondingly; the remote transmission system then being capable of transmitting a measured signal proportional to the surface melting of the glacier.
G01W 1/02 - Instruments pour indiquer des conditions atmosphériques par mesure de plusieurs variables, p. ex. humidité, pression, température, nébulosité ou vitesse du vent
35.
USE OF CARNOSOL FOR INCREASING MUSCLE PROTEIN SYNTHESIS
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
UNIVERSITE DE MONTPELLIER (France)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (France)
UNIVERSITE PAUL-VALERY MONTPELLIER 3 (France)
ECOLE PRATIQUE DES HAUTES ETUDES (EPHE) (France)
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (France)
Inventeur(s)
Carnac, Gilles
Saint, Nathalie
Morel, Sylvie
Rapior, Sylvie
Vitou, Manon
Abrégé
The present invention relates to the use of carnosol or of a composition comprising carnosol for increasing muscle protein synthesis and/or for reducing the muscle protein degradation in a subject.
C07K 7/02 - Peptides linéaires contenant au moins une liaison peptidique anormale
C07K 5/02 - Peptides ayant jusqu'à quatre amino-acides dans une séquence entièrement déterminéeLeurs dérivés contenant au moins une liaison peptidique anormale
C07D 277/56 - Atomes de carbone comportant trois liaisons à des hétéro-atomes avec au plus une liaison à un halogène
A61K 38/00 - Préparations médicinales contenant des peptides
A61K 31/00 - Préparations médicinales contenant des ingrédients actifs organiques
37.
TAXODIONE FOR ITS USE FOR PROTECTING MUSCLE AND MEAT FROM OXIDATION
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
UNIVERSITE DE MONTPELLIER (France)
INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (France)
ECOLE PRATIQUE DES HAUTES ETUDES (France)
UNIVERSITE MONTPELLIER III PAUL VALERY (France)
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (France)
Inventeur(s)
Saint, Nathalie
Rapior, Sylvie
Vitou, Manon
Bouguet, Guillaume
Carnac, Gilles
Morel, Sylvie
Abrégé
The present invention relates to the abietane diterpene taxodione and to rosemary stem extract containing taxodione for their use in treating a muscle wasting diseases and/or disorders; it also relates to the use of taxodione as natural meat preserver.
DEVICE FOR OBSERVATION AND IN SITU CHARACTERISATION OF SAMPLES UNDER EXTREME TEMPERATURE AND PRESSURE CONDITIONS, AND INSTALLATION COMPRISING SUCH DEVICE
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
SORBONNE UNIVERSITÉ (France)
UNIVERSITÉ DE LIMOGES (France)
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (IRD) (France)
Inventeur(s)
Rosier, Philippe
Munsch, Pascal
Abrégé
The object of the present invention is a device (1) for the observation and in situ characterisation of a sample (2) subjected to very high pressure and heated to a temperature of between 1300K and 1900K, comprising a DAC (3) with diamond anvils (31, 32) arranged on seats (51, 52) which is resistant to high pressure and serves as a high temperature thermal insulator, wherein said DAC (3) is associated with an inductive heating mode (7) having at least one coil (730).
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) (France)
UNIVERSITE DE LA REUNION SAINT DENIS (France)
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (IRD) (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (France)
Inventeur(s)
El Kalamouni, Chaker
Despres, Philippe
Abrégé
Flaviviruses are largely pathogenic to humans and other mammals and mostly are transmitted by mosquitoes. To combat flavivirus infections, it is urgent to propose safe and effective anti-viral compounds not only to impair the virus spread but also to mitigate the associated morbidities. Despite the development of antiviral agents from synthetic sources, a novel antiviral approach (economical, simple and environmentally friendly) is to use natural sources such as nutraceutical as preventive treatments against viral infections. The inventors demonstrated that flavonoid isoquercitrin exerts antiviral activity against African historical and Asian epidemic strains of ZIKV in human hepatoma, epithelial and neuroblastoma cell lines. They showed that isoquercitrin acts on ZIKV entry by preventing the internalization of virus particles into the host cell. Next the inventors demonstrated that Q3G exert antiviral activity against Yellow Fever Virus (YFV). These results suggest that Q3G represents a potential prophylactic agent targeting the entry of two medically relevant flavivirus and could thus be used to prevent flavivirus infection. Accordingly, the the present invention relates to use of quercetin-3 -O-glucoside for the treatment of flavivirus infections.
A61K 31/7048 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'oxygène comme hétéro-atome d'un cycle, p. ex. leucoglucosane, hespéridine, érythromycine, nystatine
A61P 31/14 - Antiviraux pour le traitement des virus ARN
41.
Vaccine compositions comprising an attenuated mutant Zika virus
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (France)
UNIVERSITE DE LA REUNION SAINT DENIS (France)
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (IRD) (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS (France)
Inventeur(s)
Despres, Philippe
Gadea, Gilles
Mavingui, Patrick
Viranaicken, Wildriss
Abrégé
The present invention relates to vaccine compositions comprising an attenuated mutant Zika virus. The inventors have introduced mutations at very specific positions that abrogate the N-glycosylation site on the E protein of the epidemic strain which will prevent the generation of auto-antibodies responsible for Guillain-Barre syndrome. The inventors have also produced additional mutations of the virus that result to a dramatic reduction of the cytopathic effects without affecting the capacity to produce high titers of virus. In particular, the present invention relates to an attenuated mutant Zika virus comprising a protein E of the epidemic strain wherein at least one amino acid residue at position 152, 156 or 158 is mutated.
C12N 7/00 - Virus, p. ex. bactériophagesCompositions les contenantLeur préparation ou purification
C07K 14/005 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de virus
A61K 39/39 - Préparations médicinales contenant des antigènes ou des anticorps caractérisées par les additifs immunostimulants, p. ex. par les adjuvants chimiques
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (France)
Inventeur(s)
Ben Hania, Wajdi
Brugere, Jean-François
Fardeau, Marie-Laure
Ollivier, Bernard
Abrégé
The present invention concerns a method for isolating an archaebacterium of order Methanomassiliicoccales of the commensal clade, the use of a culture and/or isolation medium comprising a sterile extract of a bacterial culture of a bacterium of the Eggerthella genus, for isolating and/or culturing an archaebacterium of order Methanomassiliicoccales of the commensal clade, and a pure isolated Methanomethylophilus alvus Mx-05 archaebacterium. It also concerns a method for culturing an archaebacterium of order Methanomassiliicoccales of the commensal clade.
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (France)
ECOLE NATIONALE SUPERIEURE DE CHIMIE (France)
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (IRD) (France)
UNIVERSITE D'AIX MARSEILLE (France)
COMMUNAUTE UNIVERSITES ET ETABLISSEMENTS UNIVERSITE COTE D AZUR (France)
Inventeur(s)
Crauste, Céline
Vercauteren, Joseph
Veas, Fransisco
Durand, Thierry
Blondeau, Nicolas
Abrégé
31216121112112161121112121)alkenyl group, or its pharmaceutically acceptable salts, racemates, diastereoisomers, enantiomers, or mixtures thereof, for use in prevention and/or treatment of a disease or disorder linked to an exacerbated vascular, lymphatic or mucosal permeability.
A61K 31/23 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides carboxyliques d'acides acycliques, p. ex. pravastatine d'acides ayant un groupe carboxyle lié à une chaîne d'au moins sept atomes de carbone
A61K 31/231 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides carboxyliques d'acides acycliques, p. ex. pravastatine d'acides ayant un groupe carboxyle lié à une chaîne d'au moins sept atomes de carbone ayant une ou deux doubles liaisons
A61K 31/232 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides carboxyliques d'acides acycliques, p. ex. pravastatine d'acides ayant un groupe carboxyle lié à une chaîne d'au moins sept atomes de carbone ayant au moins trois doubles liaisons, p. ex. étrétinate
C07C 69/22 - Esters d'acides acycliques monocarboxyliques saturés dont le groupe carboxyle est lié à un atome de carbone acyclique ou à l'hydrogène avec au moins trois atomes de carbone dans la partie acide
C07C 69/587 - Esters d'acides monocarboxyliques avec plusieurs liaisons doubles carbone-carbone
A61P 9/14 - VasoprotecteursAntihémorroïdauxMédicaments pour le traitement des varicesStabilisateurs capillaires
44.
DEVICE FOR FERMENTATION IN SOLID MEDIUM AND ASSOCIATED METHOD OF USE
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (IRD) (France)
Inventeur(s)
Roussos, Sevastianos
Tranier, Marie-Stéphane
Abrégé
The invention relates to a device for fermentation in solid medium, comprising a basal portion (10) forming a ventilation system, and a fermentation chamber (20) formed on the basal portion (10), the basal portion (10) comprising a plurality of ventilation openings (110) towards the fermentation chamber (20) and at least one inlet opening (12) intended for being connected to a gas source, the fermentation chamber (20) comprising at least one outlet opening (21) allowing a discharge of gas contained in said fermentation chamber (20), characterised in that the basal portion (10) and the fermentation chamber (20) are made of the same flexible material, the basal portion (10) being formed from a plurality of ventilation channels (11) arranged parallel to one another through which the plurality of ventilation openings (110) towards the fermentation chamber (20) are formed, a micro-perforated screen (30) also being attached to the basal portion (10) arranged on the ventilation channels (11) between the ventilation openings (110) and the fermentation chamber (20).
INSTITUT DE RECHERCHE POUR LE DEVELOPPMENT (IRD) (France)
Inventeur(s)
Point, David
Gautier, Anthony
Abrégé
Disclosed is a device for detecting at least one chemical species in a medium to be analyzed including a chemical sensor, the chemical sensor including: a substrate; a functionalized carrier intended for capturing and accumulating the chemical species and attached to a side of the substrate. The device also includes a unit for diffusion between the medium to be analysed and the functionalised carrier. The diffusion unit includes a vibration generating system connected to the chemical sensor in order to subject the chemical sensor to controlled vibrations.
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) (France)
UNIVERSITE DE LA REUNION SAINT DENIS (France)
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (IRD) (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (France)
Inventeur(s)
Gadea, Gilles
Girardot, Michael
Despres, Philippe
Abrégé
The present invention relates to a genomic sequences encoding for an attenuated mutant Zika virus. The inventors have introduced some specific substitutions at very specific positions in the epidemic genomic sequence for restoring some fixation sites for miR-4279 that were originally present in the endemic genomic sequence. Moreover the inventors have additionally introduced mutation leading to the abrogation of the N-glycosylation site on the E protein which will prevent the generation of auto-antibodies responsible for Guillain-Barre syndrome. The inventors have produced additional mutations of the virus that result to a dramatic reduction of the cytopathic effects without affecting the capacity to produce high titers of virus. In particular the present invention relates to a genomic sequence characterized by the sequence represented by SEQ ID NO:1 wherein at least one site of fixation for miR-4279 is restored.
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) (France)
UNIVERSITE DE LA REUNION SAINT DENIS (France)
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (IRD) (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (France)
Inventeur(s)
Despres, Philippe
Gadea, Gilles
Mavingui, Patrick
Viranaicken, Wildriss
Abrégé
The present invention relates to vaccine compositions comprising an attenuated mutant Zika virus. The inventors have introduced mutations at very specific positions that abrogate the N-glycosylation site on the E protein of the epidemic strain which will prevent the generation of auto-antibodies responsible for Guillain-Barre syndrome. The inventors have also produced additional mutations of the virus that result to a dramatic reduction of the cytopathic effects without affecting the capacity to produce high titers of virus. In particular, the present invention relates to an attenuated mutant Zika virus comprising a protein E of the epidemic strain wherein at least one amino acid residue at position 152, 156 or 158 is mutated.
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (I.R.D.) (France)
INSTITUT NATIONAL SCIENCES APPLIQUEES TECHNOLOGIE (INSAT) (Tunisie)
Inventeur(s)
Ollivier, Bernard
Fardeau, Marie-Laure
Ben Hania, Wajdi
Hamdi, Moktar
Fadhlaoui, Khaled
Abrégé
The present invention concerns a process for the co-culture of an anaerobic mesophilic bacterium pertaining to the genus Mesotoga with at least one hydrogenotrophic sulfate-reducing bacterium.
C12P 1/04 - Préparation de composés ou de compositions, non prévue dans les groupes , utilisant des micro-organismes ou des enzymesProcédés généraux de préparation de composés ou de compositions utilisant des micro-organismes ou des enzymes utilisant des bactéries
CENTRE HOSPITALIER UNIVERSITAIRE DE BORDEAUX (France)
UNIVERSITE LIBRE DE BRUXELLES (Belgique)
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (France)
Inventeur(s)
Vincendeau, Philippe
Lemesre, Jean-Loup
Pays, Etienne
Abrégé
The present invention relates to methods and compositions for preventing, treating and diagnosing infection by trypanosomes. The invention also relates to the use of excreted/secreted antigens (exoantigens, secretome) and specifically to the identification of a protein excreted/secreted by the trypanosomes, the inhibition of which makes it possible to provide effective protection, mainly by vaccination, against infection by trypanosomes or the development or spread thereof. The invention relates to use of the protein, the derivatives thereof, a nucleotide sequence derived from said protein, or an extract enriched with said protein, and to the use of antibodies directed against said trypanosomes for immunotherapy, diagnosis, and monitoring of infections by trypanosomes.
A61K 31/7105 - Acides ribonucléiques naturels, c.-à-d. contenant uniquement des riboses liés à l'adénine, la guanine, la cytosine ou l'uracile et ayant des liaisons 3'-5' phosphodiester
C07K 16/00 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
A61P 33/02 - Antiprotozoaires, p. ex. pour le traitement de la leishmaniose, de la trichomonase, de la toxoplasmose
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (France)
Inventeur(s)
Ladram, Ali
Sereno, Denis
Foulon, Thierry
Oury, Bruno
Abrégé
The present invention relates to novel antimicrobial peptides, pharmaceutical compositions comprising said peptides, and the uses thereof, in particular as antimicrobial drugs, disinfectants, pesticides or preservatives. The present invention also relates to a transgenic plant expressing said novel peptides.
C07K 14/46 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés
A61K 38/00 - Préparations médicinales contenant des peptides
51.
METHODS FOR ON DEMAND PRE-EXPOSURE PROPHYLACTIC TREATMENT OF HIV INFECTION
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) (France)
UNIVERSITÉ PARIS DIDEROT - PARIS 7 (France)
UNIVERSITÉ PARIS-SUD (France)
UNIVERSITÉ D'AIX-MARSEILLE (France)
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (IRD) (France)
ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS (France)
COMMISSARIAT À L'ÉNERGIE ATOMIQUE (France)
Inventeur(s)
Molina, Jean-Michel
Delfraissy, Jean-François
Spire, Bruno
Aboulker, Jean-Pierre
Abrégé
The present invention relates to methods for on demand pre-exposure prophylactic treatment of HIV infection. In particular, the present invention relates to a method for on demand pre-exposure prophylactic treatment of a subject at substantial risk for HIV infection comprising administering orally the subject with a combination of a therapeutically effective amount of emtricitabine and tenofovir prior and after to exposure to a potential source of HIV.
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (IRD) (France)
Inventeur(s)
Point, David
Gautier, Anthony
Abrégé
The invention relates to a device (1) for detecting at least one chemical species in a medium to be analyzed. Said device includes a chemical sensor (2). The chemical sensor (2) includes: - a substrate (4); and - a functionalized carrier (5) intended for detecting and accumulating the chemical species and attached to a surface of the substrate (4). The device also includes means for diffusion between the medium to be analyzed and the functionalized carrier (5). The device (1) is characterized in that the diffusion means include a vibration generating system (3) connected to the chemical sensor (2) in order to subject the chemical sensor (2) to controlled vibrations.
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
53.
SYSTEM AND METHOD FOR AUTOMATED IDENTIFICATION OF HAEMATOPHAGOUS DIPTERA
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (France)
Inventeur(s)
Sereno, Denis
Cannet, Arnaud
Akhoundi, Mohammad
Romain, Olivier
Histache, Aymeric
Abrégé
The invention concerns a system and a method for the automated identification of haematophagous Diptera that are vectors of infectious diseases. The system according to the invention comprises: - a database containing reference image data of wings of a plurality of species of haematophagous Diptera that are vectors of infectious diseases, said image data being obtained from optical interference patterns of said wings; a portable device comprising means for acquiring images of a wing removed from a captured Diptera specimen; - a support for holding the wing removed from the captured Diptera specimen; - means for transmitting image data of the removed wing to the database; and - means for comparing the image data of the removed wing with the reference image data of the database and for identifying the captured Diptera with a view to determining if said Diptera is a haematophagous Diptera that is a vector of infectious diseases. The invention applies to the identification of haematophagous Diptera that are vectors of infectious diseases.
G06F 19/00 - Équipement ou méthodes de traitement de données ou de calcul numérique, spécialement adaptés à des applications spécifiques (spécialement adaptés à des fonctions spécifiques G06F 17/00;systèmes ou méthodes de traitement de données spécialement adaptés à des fins administratives, commerciales, financières, de gestion, de surveillance ou de prévision G06Q;informatique médicale G16H)
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (France)
ECOLE NORMALE SUPERIEURE DE LYON (France)
HYDRO REUNION (France)
Inventeur(s)
Boussarie, Germain
Teichert, Nils
Ponton, Dominique
Lagarde, Raphaël
Abrégé
The invention concerns a method for counting aquatic species passing through a container (1, 2, 3) provided with a camera (7) having a field of view, said method comprising a step of acquiring images originating from said camera, and a measurement step during which the objects appearing on an image are measured. The method is remarkable in that it further comprises a marking step in order to associate each object with the length of same, a monitoring step for monitoring the progress of an object in said container by means of successive images, a counting step for incrementing a counter by one unit when an object has left the field of the camera (7), or in other words when it no longer appears on the current image.
G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (IRD) (France)
Inventeur(s)
Serra-Wittling, Claire
Cleyet-Marel, Jean-Claude
Abrégé
The present invention relates to a fabaceae/gramineae plant combination, inoculated with symbiotic microorganisms. The plant combination may be in the form of seeds or in the form of strips of turf. The invention also relates to the use of the plant combination for turfing urban environments with strong water and thermal constraints and the grassing of vineyards and orchards.
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (France)
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (IRD) (France)
Inventeur(s)
Carletti, Isabelle
Massiot, Georges
Abrégé
6) alkyl group. The invention also relates to the method for preparing said compound, to a pharmaceutical composition containing same, and to the use thereof as a drug, particularly for cancer treatment.
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (I.R.D.) (France)
SOCIETE INTEROLEAGINEUSE D'ASSISTANCE ET DE DEVELOPPEMENT (SIA) (France)
Inventeur(s)
Ollivier, Bernard
Ben Hania, Wajdi
Thevenieau, France
Hedi, Abdeljabbar
Fardeau, Marie-Laure
Abrégé
The invention relates to a novel hyperhalophilic strain and the use thereof for the degradation of carbon substrates, allowing, in particular, the production of novel polymers.
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (IRD) (France)
Inventeur(s)
Becquart, Pierre Jean
Leroy, Eric Maurice
Abrégé
The invention relates to immunogenic peptide, characterized in that it consists of 15 to 25 amino acids of an EBOV protein and that it comprises a sequence of 15 aminoacids selected in the group comprising sequences SEQ ID N° 1 - 61.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
C07H 21/02 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le ribosyle comme radical saccharide
C07H 21/04 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le désoxyribosyle comme radical saccharide
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
61.
Use of 4-phenylbutyric acid for improving the tolerance of plants to harmful biological organisms
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (IRD) (France)
Inventeur(s)
Cacas, Jean-Luc
Champion, Antony
Abrégé
The present invention relates to the use of 4-phenylbutyric acid, or one of the salts thereof, for improving the resistance of plants to harmful biological organisms, in particular to bacteria, viruses and nematodes, and for inhibiting hypersensitive cell death induced by such harmful biological organisms. The present invention also relates to the use of 4-phenylbutyric acid, or one of the salts thereof, as an antimicrobial agent for preventing or treating plant diseases caused by phytopathogens.
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (IRD) (France)
Inventeur(s)
Detournay, Olivier
Lorquin, Jean
Gault, Frederic
Abrégé
The invention relates to a pharmaceutical composition intended for use in the prevention and/or treatment of leukaemia in a subject, said composition comprising palytoxin (PLTX) and a pharmaceutically acceptable carrier. The application also relates to other medical uses of palytoxin and a method for its extraction from Palythoa clavata polyps. It is also described a method for isolating the symbiodinium dinoflagellate from Palythoa clavata.
A61K 31/357 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant plusieurs atomes d'oxygène dans le même cycle, p. ex. éthers en couronne, guanadrel
A61P 35/02 - Agents anticancéreux spécifiques pour le traitement de la leucémie
INSTITUT DE LA RECHERCHE POUR LE DEVELOPPEMENT (IRD) (France)
VIRBAC (France)
Inventeur(s)
Lemesre, Jean-Loup
Papierok, Gérard-Marie
Bras Goncalves, Rachel Elise
Petitdidier-Lesin, Elodie
Abrégé
The invention relates to the use, as a vaccine molecule in a mammal, of a PSA, such as a Leishmania PSA, or a part of said PSA having immunogenic properties. Said PSA, hereinafter referred to as "ES PSAr", is in a soluble, native, recombinant form. The invention also relates to a vaccine composition for preventing and/or treating Leishmaniases containing an ES PSAr protein.
C07K 14/44 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de protozoaires
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (IRD) (France)
UNIVERSITE GRENOBLE ALPES (UGA) (France)
Inventeur(s)
Gratiot, Nicolas
Mercier, Bernard
Legout, Cédric
Wendling, Valentin
Coulaud, Catherine
Mora, Henri
Abrégé
A unit for measuring the falling speed of particles in suspension in a fluid comprises a sealed container (6) having an opening (9) and defining an open compartment (15) comprising the opening and intended to contain the fluid, and a sealed compartment (16), sealing means separating the open compartment from the sealed compartment, and means for measuring the falling speed placed in the sealed compartment and comprising at least three electromagnetic radiation emitters distributed along a longitudinal axis (L) of the open compartment, each emitter being oriented according to a radiation axis crossing the open compartment at different heights along the longitudinal axis, an equal number of receivers distributed along the longitudinal axis, each receiver being placed in the radiation axis of a corresponding emitter, means for controlling the emitters and the receivers, and a system for acquiring data connected to the receivers, the acquired data being used to obtain the falling speed of the particles and the change of same as a function of the height in the open compartment and as a function of time, said change quantifying the flocculation of the particles.
G01N 15/04 - Recherche de la sédimentation des suspensions de particules
G01N 15/00 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (France)
Inventeur(s)
Garcia, André
Nuel, Grégory Nicolas Michel
Hammami, Imen
Abrégé
The invention concerns a counting device (1) for counting elements (W, X, Y, Z) during an analysis consisting of recognising and counting at least one type (3w, 3x, 3y, 3z) of defined material element in a defined material medium (3), the counting of the elements of the defined type resulting from observations, in particular visual observations, of a human operator (2) in a predefined observation field (4) of the medium (3) that can contain said elements (W, X, Y, Z), said observations consisting, for the operator, of visually recognising the elements of the defined type or types and the counting consisting, for the operator, of incrementing (5, 5'), by one, a counter (10, 10') of the counting device for counting elements of the corresponding type each time an element of said defined type that has not yet been counted is recognised, said element counter comprising a means (5, 5') of incrementing per type of element. According to the invention, the counting device further comprises a means (9) for measuring time and means for combining at least one item of time data with the incrementations, the counting device comprising electronic circuits having a microprocessor programmed with memory for storing the counting data and time data. A calculation means makes it possible to use the incrementation and time data to determine a result of the analysis of said data by calculation.
G04F 1/00 - Appareils pouvant être mis en marche et arrêtés pour mesurer des intervalles de temps prédéterminés ou choisis à volonté, sans mécanisme moteur, p. ex. sabliers
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) (France)
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (France)
Inventeur(s)
Ladram, Ali
Sereno, Denis
Foulon, Thierry
Oury, Bruno
Abrégé
The present invention relates to novel antimicrobial peptides, to pharmaceutical compositions comprising said peptides,and to the uses thereof, in particular as antimicrobial drugs, disinfectants, pesticides or preservatives. The present invention also relates to a transgenic plant expressing said novel peptides.
C07K 14/46 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés
67.
NEW COMPOUNDS FOR THE TREATMENT AND/OR PREVENTION OF PARASITIC DISEASES AND METHOD OF PRODUCTION OF THEREOF
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (I.R.D.) (France)
UNIVERSITE DE MONTPELLIER (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
Inventeur(s)
Sereno, Denis
Labesse, Gilles
Guichou, Jean-François Alexandre
Loeuillet, Corinne
Garcia, Déborah Isabelle
Delbecq, Stéphane
Abrégé
The present invention relates to new compounds for treating, preventing or inhibiting a parasitic disease, preferably toxoplasmosis in a subject, the method for preparing thereof.
C07C 259/10 - Composés contenant des groupes carboxyle, un atome d'oxygène d'un groupe carboxyle étant remplacé par un atome d'azote, cet atome d'azote étant lié de plus à un atome d'oxygène et ne faisant pas partie de groupes nitro ou nitroso sans remplacement de l'autre atome d'oxygène du groupe carboxyle, p. ex. acides hydroxamiques ayant des atomes de carbone de groupes hydroxamique liés à des atomes de carbone de cycles aromatiques à six chaînons
C07C 311/19 - Sulfonamides ayant des atomes de soufre de groupes sulfonamide liés à des atomes de carbone de cycles aromatiques à six chaînons ayant l'atome d'azote d'au moins un des groupes sulfonamide lié à des atomes d'hydrogène ou à un atome de carbone acyclique à un atome de carbone acyclique d'un radical hydrocarboné substitué par des groupes carboxyle
C07C 311/21 - Sulfonamides ayant des atomes de soufre de groupes sulfonamide liés à des atomes de carbone de cycles aromatiques à six chaînons ayant l'atome d'azote d'au moins un des groupes sulfonamide lié à un atome de carbone d'un cycle aromatique à six chaînons
C07D 277/30 - Radicaux substitués par des atomes de carbone comportant trois liaisons à des hétéro-atomes, avec au plus une liaison à un halogène, p. ex. radicaux ester ou nitrile
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (France)
UNIVERSIDAD PERUANA CAYETANO HEREDIA (Pérou)
Inventeur(s)
Arevalo, Jorge
Deharo, Eric
Privat-Maldonado, Angela
Abrégé
The present invention relates to peptides and methods for the detection of anti-leishmanial antibodies in individuals suspected of infection with the protozoan parasite of the genus Leishmania, especially infection with a South American strain causing the American Tegumentary Leishmaniasis (ATL).
G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
69.
INTERNAL DNA STANDARDS FOR ASSAYS USING MICRO-ELECTROPHORESIS
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S) (France)
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (France)
UNIVERSITE D'AIX-MARSEILLE (France)
Inventeur(s)
Viallat, Annie Madeleine Jeanne
Combet-Blanc, Yannick Aman Baptiste
Cosentino, Katia
De Meo, Michel
Abrégé
The present invention relates to capsules enclosing nucleic acid fragments of variable controlled sizes suitable to be used as an internal standard in micro-electrophoresis assays, such as single cell micro-electrophoresis assays.
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
G01N 33/96 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir un étalon de contrôle du sang ou du sérum
70.
AEDES AEGYPTI PROTEIN USABLE AS A TARGET FOR PREVENTING OR TREATING A DENGUE INFECTION
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (IRD) (France)
Inventeur(s)
Misse Brumas, Marthe Dorothée
Surasombatpattana, Pornapat
Hamel, Rodolphe
Abrégé
The invention relates to a use for preventing or treating a dengue infection, consisting of a putative 34 kDa family secreted salivary protein (GenBank accession number Q1HRW0 AEDAE) of Aedes aegypti.
A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (France)
Inventeur(s)
Aldana Moraza, Ignacio
Blair Trujillo, Silvia
Deharo, Eric
Garavito, Giovanny
Mendoza Lizaldez, Adela
Perez-Silanes, Silvia
Abrégé
The present invention relates to new arylaminoalcohol derivatives of formula (I), and to a method for the preparation of such compounds: The invention also relates to the use of these compounds as medicaments, and in particular for the prevention and/or the treatment of parasitic diseases caused by apicomplexan parasites such as malaria and toxoplasmosis. Finally, the invention relates to pharmaceutical compositions containing such compounds of formula (I) as active principles.
C07D 409/06 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne carbonée contenant uniquement des atomes de carbone aliphatiques
C07D 211/70 - Composés hétérocycliques contenant des cycles pyridiques hydrogénés, non condensés avec d'autres cycles avec uniquement des atomes d'hydrogène et de carbone liés directement à l'atome d'azote du cycle comportant une liaison double entre chaînons cycliques ou entre chaînon cyclique et chaînon non cyclique avec uniquement des atomes d'hydrogène, des radicaux hydrocarbonés ou des radicaux hydrocarbonés substitués, liés directement aux atomes de carbone du cycle
A61K 31/44 - Pyridines non condenséesLeurs dérivés hydrogénés
A61K 31/551 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole ayant deux atomes d'azote comme hétéro-atomes d'un cycle, p. ex. clozapine, dilazèpe
A61P 31/18 - Antiviraux pour le traitement des virus ARN du HIV
A61P 33/02 - Antiprotozoaires, p. ex. pour le traitement de la leishmaniose, de la trichomonase, de la toxoplasmose
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (France)
Inventeur(s)
Aldana Moraza, Ignacio
Blair Trujillo, Silvia Victoria
Deharo, Eric
Garavito, Giovanny
Mendoza Lizaldez, Adela
Perez-Silanes, Silvia
Abrégé
The present invention relates to new arylaminoalcohol derivatives of formula (I), and to a method for the preparation of such compounds: I The invention also relates to the use of these compounds as medicaments, and in particular for the prevention and/or the treatment of parasitic diseases caused by apicomplexan parasites such as malaria and toxoplasmosis. Finally, the invention relates to pharmaceutical compositions containing such compounds of formula (I) as active principles.
C07D 409/06 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne carbonée contenant uniquement des atomes de carbone aliphatiques
C07D 211/70 - Composés hétérocycliques contenant des cycles pyridiques hydrogénés, non condensés avec d'autres cycles avec uniquement des atomes d'hydrogène et de carbone liés directement à l'atome d'azote du cycle comportant une liaison double entre chaînons cycliques ou entre chaînon cyclique et chaînon non cyclique avec uniquement des atomes d'hydrogène, des radicaux hydrocarbonés ou des radicaux hydrocarbonés substitués, liés directement aux atomes de carbone du cycle
A61K 31/44 - Pyridines non condenséesLeurs dérivés hydrogénés
A61K 31/551 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole ayant deux atomes d'azote comme hétéro-atomes d'un cycle, p. ex. clozapine, dilazèpe
A61P 31/18 - Antiviraux pour le traitement des virus ARN du HIV
73.
SOLID STATE FERMENTATION DEVICE AND PRODUCTS OBTAINED
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (IRD) (France)
Inventeur(s)
Roussos, Sevastianos
Labrousse, Yoan Jean-Charles
Lakhtar, Hicham
Tranier, Marie Stéphane
Abrégé
The invention concerns a solid state fermentation (SSF) device, characterised in that it comprises - a rigid outer mould (1) - an inner portion forming a removable single-use fermentation chamber (2) formed from a flexible material and comprising 2 portions, - the lower portion (8), or lower chamber, which is harder and has a shape almost identical to that of the container (3), - the upper portion (10) or upper chamber intended to enclose the material that is to be fermented, formed from a more flexible material, the useful volume thereof being greater than that of the lower portion, - aeration means being provided between these two portions.
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (France)
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (IRD) (France)
Inventeur(s)
Carletti, Isabelle
Massiot, Georges
Abrégé
The present invention relates to a compound of the following formula (I) or to a salt, hydrate, or pharmaceutically acceptable solvate thereof, in which R is a monosaccharide or disaccharide residue. The hydroxyl functions of the monosaccharide or disaccharide residue are, independently, optionally substituted for a (C1-C6) alkyl or -C(O)NH- (C1-C6) alkyl group. The invention also relates to the method for preparing said compound, to a pharmaceutical composition containing same, and to the use thereof as a drug, particularly for cancer treatment.
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (IRD) (France)
Inventeur(s)
Tuikue Ndam, Nicaise
Deloron, Philippe
Doritchamou, Justin
Abrégé
The present invention relates to combinations of polypeptides or of polynucleotides corresponding to a specific region of the N-terminal portion of the VAR2CSA protein of different parasitic families or lines of Plasmodium falciparum, and to their use in the prevention of pregnancy-associated malaria. The invention also relates to immunogenic compositions and to vaccines useful for preventing malaria in pregnant women.
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (IRD) (France)
Inventeur(s)
Papierok, Gérard-Marie
Lemesre, Jean-Loup
Gueguen, Sylvie
Bras Goncalves, Rachel, Elise
Petitdidier-Lesin, Elodie
Abrégé
The invention relates to monoepitopic or polyepitopic peptidic compounds of sequence SEQ ID N° 1 to 16 and to the analogous, mutein and homologous derivatives thereof, for the prevention and treatment of Leishmaniases in mammals and especially in humans, canines, felines and equines. The invention especially relates to vaccines comprising said peptidic compounds in conditions ensuring immunisation leading to effective protection of the vaccinated human or animal against at least one Leishmania.
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) (France)
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (IRD) (France)
UNIVERSITE PAUL SABATIER TOULOUSE III (France)
Inventeur(s)
Coste, Agnès
Dardenne, Christophe
Pipy, Bernard
Abrégé
The present invention relates to acetylsalicylic acid or a salt thereof, at a concentration comprised between 200 and 4800 μΜ, for use in the prevention and/or treatment of diabetic wounds.
A61P 9/14 - VasoprotecteursAntihémorroïdauxMédicaments pour le traitement des varicesStabilisateurs capillaires
A61P 9/10 - Médicaments pour le traitement des troubles du système cardiovasculaire des maladies ischémiques ou athéroscléreuses, p. ex. médicaments antiangineux, vasodilatateurs coronariens, médicaments pour le traitement de l'infarctus du myocarde, de la rétinopathie, de l'insuffisance cérébro-vasculaire, de l'artériosclérose rénale
78.
MOLECULAR MARKERS AND METHODS FOR IDENTIFYING DATE PALM GENOTYPES
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (IRD) (France)
LABORATOIRE DE GÉNÉTIQUE MOLÉCULAIRE, IMMUNOLOGIE ET BIOTECHNOLOGIE LABB02 DE LA FACULTÉ DES SCIENCES MATHÉMATIQUES, PHYSIQUES ET NATURELLES DE TUNIS (Tunisie)
Inventeur(s)
Aberlenc-Bertossi, Frédérique
Pintaud, Jean-Christophe
Chabrillange, Nathalie
Cherif, Emira
Castillo-Perez, Karina
Zehdi, Salwa
Abrégé
The present invention concerns two sets of mini- and micro-satellite molecular markers, and the use thereof to study the genetic diversity and/or identify the genotypes of date palms. The invention also concerns method for identifying date palm cultivars using these sets of molecular markers, and kits for implementing these methods.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
79.
TOOLS AND METHOD FOR THE DETECTION AND QUANTIFICATION OF GENETICALLY DIVERSE HIV-1,SIVCPZ AND SIV GOR VIRUSES
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (IRD) (France)
Inventeur(s)
Peeters, Martine
Etienne, Lucie
Abrégé
The invention relates to the oligonucleotide of sequence SEQ ID N°1 : 5'- CTAGAGATCCCTCAGA - 3 ', and the complementary sequence thereof of sequence SEQ ID N° 2: 5 '- TCTGAGGGATCTCT AG - 3 ' useful as probes to detect and quantify all HIV-1 circulating forms and their precursors SIVcpz/SIVgor.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
80.
PROGNOSTIC OF DIET IMPACT ON OBESITY-RELATED CO-MORBIDITIES
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (France)
UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) (France)
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (IRD) (France)
Inventeur(s)
Ehrlich, Stanislav
Dore, Joël
Le Chatelier (epouse Janniere), Emmanuelle
Clement (epouse Lausch), Karine
Zucker, Jean-Daniel
Abrégé
The present invention relates to a method for determining whether an overweight subject has a reduced gut bacterial diversity. The said method comprises detecting the presence or absence in a gut DNA sample of at least one gene of at least one bacterial species of Table 1 or Table 2, respectively.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
81.
MOLECULAR MARKERS AND METHODS FOR EARLY SEX DETERMINATION IN DATE PALMS
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (IRD) (France)
LABORATOIRE DE GENETIQUE MOLECULAIRE (Tunisie)
Inventeur(s)
Aberlenc, Frédéric
Cherif, Emira
Abrégé
The present invention relates to molecular markers and to the use thereof for distinguishing male date palm plants from female date palm plants. The invention also relates to a method for identifying the sex of date palm plants using these molecular markers, and to a kit for carrying out the method.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
82.
USE OF 4-PHENYLBUTYRIC ACID FOR IMPROVING THE TOLERANCE OF PLANTS TO HARMFUL BIOLOGICAL ORGANISMS
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (IRD) (France)
Inventeur(s)
Cacas, Jean-Luc
Champion, Antony
Abrégé
The present invention relates to the use of 4-phenylbutyric acid, or one of the salts thereof, for improving the resistance of plants to harmful biological organisms, in particular to bacteria, viruses, and nematodes, and for inhibiting the cell death of the hypersensitive response induced by such harmful biological organisms. The present invention also relates to the use of 4-phenylbutyric acid, or one of the salts thereof, as an antimicrobial agent for preventing or treating plant diseases caused by phytopathogens.
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (I.R.D.) (France)
CENTRE DE COOPERATION INTERNATIONALE EN RECHERCHE AGRONOMIQUE POUR LE DEVELOPPEMENT (CIRAD) (France)
UNIVERSITE CADI AYYAD-FACULTE DES SCIENCES SEMLALIA, MARRAKECH-MAROC (Maroc)
Inventeur(s)
Duponnois, Robin
Prin, Yves
Hafidi, Mohamed
Ouahmane, Lahcen
Boumezzough, Ali
Abrégé
The present invention concerns the use of at least one seed or plant chosen from the Lamiaceae family and precultured in an area of ground for revegetation, in particular an area of ground for revegetation having a volume of approximately 0.5L, in particular for approximately 3 to 6 months, in particular 5 months, to produce a precultured plant, said precultured plant being uprooted from the area of ground after said precultivation, for the multiplication of mycorrhizal fungi and for improving the growth of at least one seed or plant of forest and/or fruit species in said ground for revegetation.
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (IRD) (France)
Inventeur(s)
De Kochko, Alexandre
Hamon, Perla
Hatt, Clémence
Poncet, Valérie
Hamon, Serge
Guyot, Romain
Tranchant-Dubreuil, Christine
Abrégé
The present invention relates to Clem2, the first active LTR retrotransposon identified in the coffee plant, and its use in the clonal and/or varietal identification of coffee plants. The invention provides PCR primers, kits comprising such PCR primers, and methods using such kits and/or PCR primers for the clonal and/or varietal identification of several coffee species. The primers, kits and methods are particularly useful for coffee certification and traceability.
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (France)
Inventeur(s)
Rojas Duran, Rosario Elena
Shiva Ramayoni, Carlos Martín
Kalinowski Echegaray, Juan
Villavicencio Gallarday, Christian Alejandro
Sauvain, Michel Henri Auguste
Abrégé
The invention relates to a composition of lemon peel essential oil useful as a growth promoter in poultry, said composition comprises at least 16.84 to 46.12 % d-limonene; 5.67 to 19.86 % y-terpinene; 4.27 to 12.13 % terpinolene; 4.60 to 14.75 % p-menth-1-3n-8-ol; among other components. The invention also relates to a food supplement for poultry, which comprises 1 kg per metric ton of feed of the said essential oil composition.
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (IRD) (France)
Inventeur(s)
Champion, Antony
Abrégé
La present invention relates to the use of a nucleic sequence allowing the synthesis of Gh ERF-IIa, Gh ERF-IIb or Gh ERF-IIc in a plant in order to induce, in the plant, an overproduction or accumulation of jasmonic acid and/or OPDA. The accumulation of jasmonic acid and/or OPDA confers, in particular, to the transformed plant an improved resistance to bioagressors. The nucleic sequences, transformation methods and transformed plants according to the invention may also been used for the production of pharmaceutically important secondary metabolites whose synthesis is induced by jasmonates.
A01H 5/00 - Angiospermes, c.-à-d. plantes à fleurs, caractérisées par leurs parties végétalesAngiospermes caractérisées autrement que par leur taxonomie botanique
C12N 15/82 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules végétales
A01N 63/02 - Substances produites par, ou obtenues à partir de micro-organismes ou d'animaux
88.
PROTECTIVE DEVICE FOR PROTECTING A FISH CAUGHT ON A HOOK AND FISHING SYSTEM INCLUDING SUCH A PROTECTIVE DEVICE
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (IRD) (France)
Inventeur(s)
Bach, Pascal
Rabearisoa, Njaratiana
Cotel, Pascal
Lamoureux, Jean-Pierre
Abrégé
The invention relates to a protective device (15) for protecting a fish (2) caught on a hook, said protective device (15) comprising a body (16) and a plurality of elongate protective elements (17), wherein the plurality of protective elements (17) includes first protective elements (17a) having a first buoyancy for being deployed by moving away from the body (16) above the hook and second protective elements (17b) having a second buoyancy, which is less than the first buoyancy, for surrounding the hook.
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (IRD) (France)
Inventeur(s)
Migot-Nabias, Florence
Dechavanne, Célia
Guillonneau, François
Dugoujon, Jean-Michel
Lefranc, Marie-Paule
Abrégé
The present invention provides a method for determining the amino acid polymorphisms of heavy gamma chain of immunoglobulins G by a proteomic approach. This method distinguishes the immunoglobulins of the mother and those of the newborn in a blood sample obtained during the first months of the child's life. The invention also relates to the use of this method in the early diagnosis of vertically transmitted diseases in the neonate. The invention also provides peptides distinctive of G3m and IGHG3 alleles, and a kit comprising said peptides.
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
90.
DEVICE FOR MEASUREMENT COUPLED WITH WATER PARAMETERS OF SOIL
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (IRD) (France)
Inventeur(s)
Bellier, Gérard
Braudeau, Erik
Abrégé
The invention relates to an apparatus for physically analyzing soil or another natural, organized medium, comprising a sample changer (100) capable of receiving at least two soil-sample holders (1), said sample changer having a means for placing each sample holder and the sample (2) thereof in a measurement area, in turns, according to a cycle repeated over time, the apparatus including: a means for measuring the size of said samples; a means for measuring the potential of said samples containing water; and a means for measuring the weight of said samples, wherein all of said measuring means are grouped together in said measurement area so as to be simultaneously used implemented for a given sample when the latter is placed in said measurement area. The shrinkage curve and the water potential curve, which are obtained from said measurements, represent the change, over time, in the status of the water and structure of the soil sample during the drying thereof, and can be used to determine the hydrostructural characteristics of the soil.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
91.
METHOD OF DETERMINING THE HYDROSTRUCTURAL PARAMETERS OF A SOIL
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (IRD) (France)
Inventeur(s)
Braudeau, Erik
Boukcim, Hassan
Abrégé
A method of quantitative characterisation of an organised natural medium such as a soil, comprising steps consisting of: • a) - taking a sample of said natural medium; • b) - saturating the sample with water; • c) - placing the sample in an recipient at a set temperature suitable for causing gradual desiccation, from the saturated state to the dry state of said sample, and measuring the dimensions, water potential, and mass thereof, said measurements being taken from the sample simultaneously and repeated at predetermined time intervals throughout the desiccation period; • d) - plotting the shrinkage curve (V, W) and the water potential curve (h, W); and • e) - analysing all of said curves {V, W) and {h, W) in order to determine the parameters characterising the thermodynamic balance status of said structured medium with any water content, said analysis comprising at least one operation of adjusting said measured curves with the theoretical curves corresponding to the thermodynamic equations of the system as a function of water content W. The method provides a reliable and generic tool for predicting the long-term impact of industrial products on soils and for managing natural resources appropriately.
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (I.R.D.) (France)
Inventeur(s)
Darriet, Frédéric
Zumbo, Betty
Corbel, Vincent, Bernard, Camille
Chandre, Fabrice, Philippe, Pierre
Abrégé
Composition for anti-mosquito use comprising the combination of at least one fertilizer of NPK type with at least one anti-mosquito larvicide compound.
A01N 59/00 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des éléments ou des composés inorganiques
A01N 59/08 - Chlorures des métaux alcalinsChlorures des métaux alcalino-terreux
A01N 43/22 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un ou plusieurs atomes d'oxygène ou de soufre comme uniques hétéro-atomes du cycle avec un hétéro-atome des cycles à plus de six chaînons
A01N 43/40 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un atome d'azote comme unique hétéro-atome du cycle des cycles à six chaînons
A01N 47/34 - Urées ou thiourées contenant les groupes N—CO—N ou N—CS—N contenant les groupes p. ex. biuretLeurs thio-analoguesProduits de condensation urée-aldéhyde
A01N 49/00 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés comportant le groupe dans lequel m + n ≥ 1, les deux X ensemble peuvent aussi représenter —Y— ou une liaison directe carbone-carbone, et les atomes de carbone marqués d'un astérisque ne font partie d'aucun système cyclique à l'exception de celui qui peut être formé avec les atomes X, les atomes de carbone placés entre crochets font partie d'une structure acyclique ou cyclique quelconque, ou le groupe dans lequel A représente un atome de carbone ou Y, n ≥ 0, et pas plus d'un de ces atomes de carbone n'est un chaînon du même système cyclique, p. ex. hormones juvéniles des insectes ou substances ayant le même effet
A01N 63/00 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des micro-organismes, des virus, des champignons microscopiques, des animaux ou des substances produites par, ou obtenues à partir de micro-organismes, de virus, de champignons microscopiques ou d'animaux, p. ex. enzymes ou produits de fermentation
93.
THERAPEUTIC VACCINE COMPOSITIONS INDUCING TOLERANCE TO HIV FOR TREATING HIV INFECTIONS IN HUMANS
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (IRD) (France)
Inventeur(s)
Andrieu, Jean-Marie
Lu, Louis
Abrégé
The present invention is related to a therapeutic mucosal or intradermal or intraepithelial vaccine composition for use in a method for treating an infection by a HIV virus in a human in need thereof, comprising: - an antigen made of inactivated autologous HIV virus; and - a tolerogenic adjuvant which, when combined to said antigen in said therapeutic vaccine composition, induces and, preferably, maintains immunotolerance to said HIV virus in said human, thereby treating said infection in said human. More precisely, the therapeutic vaccine compositions of the present invention produce a virus-specific non-cytotoxic MHC-lb/E-restricted suppressive CD8+ T cell- induced immunotolerance ("Ts" immunotolerance for "T suppressive" immunotolerance) upon mucosal or intradermal or intraepithelial administration to humans. "Ts" immunotolerance is associated with the suppression of viral replication. The present invention also relates to a method for treating an infection by a HIV virus in a human in need thereof, comprising at least the step of mucosally or intradermally or intraepithelial administering a therapeutic vaccine composition as defined above to said human.
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (IRD) (France)
Inventeur(s)
Andrieu, Jean-Marie
Lu, Louis
Abrégé
The present invention relates to pharmaceutical compositions comprising a mixture of a specific HIV antigen and a non-pathogenic living bacterium. Said specific HIV antigen comprises one or more epitopes from Gag and/or Pol proteins and is preferably under a particulate form. Said bacterium is preferably Lactobacillus plantarum. These compositions are useful for preventing and/or treating an HIV disease in humans.
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (IRD) (France)
Inventeur(s)
Ponton, Dominique
Cornubert, Ondine
Abrégé
Underwater device (10) providing propulsion and capturing images of a seabed, comprising a hydrodynamic thruster (3) fitted with handles (39) held by a diver (90), a support (2) fixed to the hydrodynamic thruster, a photo/video camera device (4; 7) for capturing images and which is fixed to said support and aimed towards the seabed, said support being equipped with at least two generators of laser beams (5; 5') aimed at the field of view of the photo/video camera device, each generator being designed to generate a laser beam (51; 53, 54) that produces a light spot on the seabed.
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (I.R.D.) (France)
UNIVERSITE CADI AYYAD-FACTULTE DES SCIENCES SEMLALIA, MARRAKECH-MAROC (Maroc)
CENTRE DE COOPERATION INTERNATIONALE EN RECHERCHE AGRONOMIQUE POUR LE DEVELOPPEMENT (CIRAD) (France)
Inventeur(s)
Duponnois, Robin
Hafidi, Mohamed
Prin, Yves
Ouhdouch, Yadir
Abrégé
The present invention relates to novel fungal inocula compositions, to the method for preparing same, and to the use thereof for enhancing culture growth. (No drawings)
A01N 25/26 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, caractérisés par leurs formes, ingrédients inactifs ou modes d'applicationSubstances réduisant les effets nocifs des ingrédients actifs vis-à-vis d'organismes autres que les animaux nuisibles sous forme de particules revêtues
A01P 21/00 - Régulateurs de croissance des végétaux
C05F 11/08 - Engrais organiques comportant l'addition de cultures bactériennes, de mycélium ou similaires
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (I.R.D) (France)
Inventeur(s)
Sereno, Denis
Gazanion, Elodie
Vergnes, Baptiste
Guichou, Jean-François
Labesse, Gilles
Abrégé
The present invention relates to a method of treating, preventing or inhibiting parasitic disease, in particular leishmaniasis or trypanosomiasis in a subject, by a compound of formula (1): R2-A-R1 wherein: - A represents a group chosen from a phenyl, a triazolyl, and a thienyl, - R1 represents -CO-CH2OH or -CO-NHOH, - R2 is chosen from H, triazolyl, methyltriazolyl, -CONHR3, -CH2-CONHR3, - 'NHS02NHR3, -CH2-NHSO2NHR3, wherein R3 represents H, a (C1-C8) alkyl group, an aryl group, a (C3-C8) cycloalkyl group, a heterocyclic group, or a heteroaryl group. Or a pharmaceutically acceptable salt thereof.
C07C 49/172 - Composés saturés comportant des groupes cétone liés à des atomes de carbone acycliques contenant des groupes hydroxyle contenant des cycles
C07C 235/34 - Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des atomes d'oxygène ayant des atomes de carbone de groupes carboxamide liés à des atomes de carbone acycliques et des atomes d'oxygène, liés par des liaisons simples, liés au même squelette carboné le squelette carboné contenant des cycles aromatiques à six chaînons ayant les atomes d'azote des groupes carboxamide liés à des atomes d'hydrogène ou à des atomes de carbone acycliques
A61P 33/02 - Antiprotozoaires, p. ex. pour le traitement de la leishmaniose, de la trichomonase, de la toxoplasmose
A61K 31/165 - Amides, p. ex. acides hydroxamiques ayant des cycles aromatiques, p. ex. colchicine, aténolol, progabide
C07C 259/10 - Composés contenant des groupes carboxyle, un atome d'oxygène d'un groupe carboxyle étant remplacé par un atome d'azote, cet atome d'azote étant lié de plus à un atome d'oxygène et ne faisant pas partie de groupes nitro ou nitroso sans remplacement de l'autre atome d'oxygène du groupe carboxyle, p. ex. acides hydroxamiques ayant des atomes de carbone de groupes hydroxamique liés à des atomes de carbone de cycles aromatiques à six chaînons
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (IRD) (France)
Inventeur(s)
Tuikue Ndam, Nicaise
Deloron, Philippe
Gnidéhou, Sédami Ursula Alix Carine
Quiviger, Mickaël
Bigey, Pascal
Scherman, Daniel
Abrégé
The present invention relates to specific regions of the N-terminal portion of the VAR2CSA protein and to the use of such specific regions in the prevention of pregnancy-associated malaria. The invention also provides immunogenic compositions and vaccines that are useful for preventing malaria in pregnant women.
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
A61K 39/015 - Antigènes d'Hemosporidia, p. ex. antigènes de Plasmodium
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (France)
INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (IRD) (France)
Inventeur(s)
Champion, Antony
Nicole, Michel
Doumas, Patrick
Abrégé
The present invention relates to methods for obtaining a transgenic plant that overproduces jasmonic acid, and optionally OPDA, a jasmonic acid precursor. Said methods include transforming the plant using a nucleic acid encoding ORA47. The accumulation of jasmonic acid confers in particular to the transformed plant an improved resistance to pathogenic agents. The transgenic plants obtained may also be used for the production of pharmaceutically important secondary metabolites whose synthesis is induced by jasmonates.