wherein the rotation element and/or the base element comprise one or more raised portions (4) and/or one or more lowered portions (5) over which portions the one or more bearings (3) pass in order to periodically increase and decrease axial distance between the rotation element (1) and the base element (2) as rotation occurs, thereby imparting an oscillatory axial motion to the rotation element (1) relative to the base element (2).
E21B 7/24 - Forage utilisant des moyens vibrants ou oscillants, p. ex. des masses déséquilibrées
E21B 28/00 - Dispositions pour la génération de vibrations pour les trous de forage ou les puits, p. ex. pour activer la production
B06B 1/10 - Procédés ou appareils pour produire des vibrations mécaniques de fréquence infrasonore, sonore ou ultrasonore utilisant l'énergie mécanique
B06B 1/12 - Procédés ou appareils pour produire des vibrations mécaniques de fréquence infrasonore, sonore ou ultrasonore utilisant l'énergie mécanique fonctionnant avec des systèmes impliquant des masses en mouvement alternatif
Provided is a device for converting rotary motion into oscillatory axial motion, which device comprises: (a) a rotation element (1); (b) a base element (2); and (c) one or more bearings (3) for facilitating rotary motion of the rotation element relative to the base element; wherein the rotation element and/or the base element comprise one or more raised portions (4) and/or one or more lowered portions (5) over which portions the one or more bearings (3) pass in order to periodically increase and decrease axial distance between the rotation element (1) and the base element (2) as rotation occurs, thereby imparting an oscillatory axial motion to the rotation element (1) relative to the base element (2).
E21B 28/00 - Dispositions pour la génération de vibrations pour les trous de forage ou les puits, p. ex. pour activer la production
B06B 1/10 - Procédés ou appareils pour produire des vibrations mécaniques de fréquence infrasonore, sonore ou ultrasonore utilisant l'énergie mécanique
E21B 7/24 - Forage utilisant des moyens vibrants ou oscillants, p. ex. des masses déséquilibrées
Provided is a device for converting rotary motion into oscillatory axial motion, which device comprises: (a) a rotation element (1); (b) a base element (2); and (c) one or more bearings (3) for facilitating rotary motion of the rotation element relative to the base element; wherein the rotation element and/or the base element comprise one or more raised portions (4) and/or one or more lowered portions (5) over which portions the one or more bearings (3) pass in order to periodically increase and decrease axial distance between the rotation element (1) and the base element (2) as rotation occurs, thereby imparting an oscillatory axial motion to the rotation element (1) relative to the base element (2).
E21B 28/00 - Dispositions pour la génération de vibrations pour les trous de forage ou les puits, p. ex. pour activer la production
B06B 1/10 - Procédés ou appareils pour produire des vibrations mécaniques de fréquence infrasonore, sonore ou ultrasonore utilisant l'énergie mécanique
E21B 7/24 - Forage utilisant des moyens vibrants ou oscillants, p. ex. des masses déséquilibrées
E21B 7/24 - Forage utilisant des moyens vibrants ou oscillants, p. ex. des masses déséquilibrées
E21B 49/00 - Test pour déterminer la nature des parois des trous de forageEssais de couchesProcédés ou appareils pour prélever des échantillons du terrain ou de fluides en provenance des puits, spécialement adaptés au forage du sol ou aux puits
E21B 44/00 - Systèmes de commande automatique spécialement adaptés aux opérations de forage, c.-à-d. systèmes à fonctionnement autonome ayant pour rôle d'exécuter ou de modifier une opération de forage sans l'intervention d'un opérateur humain, p. ex. systèmes de forage commandés par ordinateurSystèmes spécialement adaptés à la surveillance de plusieurs variables ou conditions de forage
E21B 41/00 - Matériel ou accessoires non couverts par les groupes
E21B 10/46 - Trépans caractérisés par des parties résistant à l'usure, p. ex. des diamants rapportés
E21B 44/04 - Commande automatique de l'avance de l'outil en réponse au couple fourni par le moyen d'entraînement
G06F 17/13 - Opérations mathématiques complexes pour la résolution d'équations d'équations différentielles
E21B 44/00 - Systèmes de commande automatique spécialement adaptés aux opérations de forage, c.-à-d. systèmes à fonctionnement autonome ayant pour rôle d'exécuter ou de modifier une opération de forage sans l'intervention d'un opérateur humain, p. ex. systèmes de forage commandés par ordinateurSystèmes spécialement adaptés à la surveillance de plusieurs variables ou conditions de forage
E21B 44/02 - Commande automatique de l'avance de l'outil
G06K 9/66 - Méthodes ou dispositions pour la reconnaissance utilisant des moyens électroniques utilisant des comparaisons ou corrélations simultanées de signaux images avec une pluralité de références, p.ex. matrice de résistances avec des références réglables par une méthode adaptative, p.ex. en s'instruisant
E21B 41/00 - Matériel ou accessoires non couverts par les groupes
G05B 13/02 - Systèmes de commande adaptatifs, c.-à-d. systèmes se réglant eux-mêmes automatiquement pour obtenir un rendement optimal suivant un critère prédéterminé électriques
E21B 6/00 - Moyens d'entraînement pour forage avec action combinée de percussion et de rotation
E21B 49/00 - Test pour déterminer la nature des parois des trous de forageEssais de couchesProcédés ou appareils pour prélever des échantillons du terrain ou de fluides en provenance des puits, spécialement adaptés au forage du sol ou aux puits
(c) at least one drill bit steering insert, capable of extending and retracting so as to change the cutting characteristics of the drill bit and thereby change the direction of drilling.
Further provided is a method of directional drilling, employing the apparatus of the invention.
Provided is a method for controlling a resonance enhanced rotary drill comprising a drilling module and a control system for controlling one or more drilling parameters of the drilling module, which method comprises: (a) employing one or more initial characteristics of the material being drilled, and/or one or more initial drilling parameters to control the drilling module; (b) measuring one or more current drilling parameters to obtain one or more measured drilling parameters; (c) employing the one or more measured drilling parameters as an input in the control system, in order to obtain an output from the control system, which output comprises one or more calculated characteristics of the material being drilled; (d) employing the one or more calculated characteristics of the material being drilled, and/or the one or more measured drilling parameters, as an input in the control system, in order to obtain an output from the control system, which output comprises one or more calculated drilling parameters; (e) optionally applying the one or more calculated drilling parameters to the drilling module; (f) optionally repeating steps (b), (c) (d) and (e).
E21B 44/00 - Systèmes de commande automatique spécialement adaptés aux opérations de forage, c.-à-d. systèmes à fonctionnement autonome ayant pour rôle d'exécuter ou de modifier une opération de forage sans l'intervention d'un opérateur humain, p. ex. systèmes de forage commandés par ordinateurSystèmes spécialement adaptés à la surveillance de plusieurs variables ou conditions de forage
E21B 44/02 - Commande automatique de l'avance de l'outil
E21B 45/00 - Mesure du temps de forage ou de la vitesse de pénétration
G05D 17/02 - Commande d'un coupleCommande de la puissance mécanique caractérisée par l'utilisation de moyens électriques
Provided is an apparatus for use in resonance enhanced drilling, which apparatus comprises a drilling module comprising a drill-bit, wherein the apparatus further comprises: a sensor for measuring one or more parameters relating to the interaction of the drill-bit and the material being drilled; and a sensor for measuring one or more motions of the drill-bit.
E21B 44/00 - Systèmes de commande automatique spécialement adaptés aux opérations de forage, c.-à-d. systèmes à fonctionnement autonome ayant pour rôle d'exécuter ou de modifier une opération de forage sans l'intervention d'un opérateur humain, p. ex. systèmes de forage commandés par ordinateurSystèmes spécialement adaptés à la surveillance de plusieurs variables ou conditions de forage
E21B 47/013 - Dispositifs spécialement adaptés pour supporter des instruments de mesure sur des trépans de forage
E21B 7/24 - Forage utilisant des moyens vibrants ou oscillants, p. ex. des masses déséquilibrées
Provided is a method for controlling a resonance enhanced rotary drill comprising a drilling module and a control system for controlling one or more drilling parameters of the drilling module, which method comprises: (a) employing one or more initial characteristics of the material being drilled, and/or one or more initial drilling parameters to control the drilling module; (b) measuring one or more current drilling parameters to obtain one or more measured drilling parameters; (c) employing the one or more measured drilling parameters as an input in the control system, in order to obtain an output from the control system, which output comprises one or more calculated characteristics of the material being drilled; (d) employing the one or more calculated characteristics of the material being drilled, and/or the one or more measured drilling parameters, as an input in the control system, in order to obtain an output from the control system, which output comprises one or more calculated drilling parameters; (e) optionally applying the one or more calculated drilling parameters to the drilling module; (f) optionally repeating steps (b), (c) (d) and (e).
G05B 13/02 - Systèmes de commande adaptatifs, c.-à-d. systèmes se réglant eux-mêmes automatiquement pour obtenir un rendement optimal suivant un critère prédéterminé électriques
G06K 9/66 - Méthodes ou dispositions pour la reconnaissance utilisant des moyens électroniques utilisant des comparaisons ou corrélations simultanées de signaux images avec une pluralité de références, p.ex. matrice de résistances avec des références réglables par une méthode adaptative, p.ex. en s'instruisant
10.
RESONANCE ENGHANCED ROTARY DRILLING APPARATUS AND METHOD
Provided is an apparatus for use in resonance enhanced drilling, which apparatus comprises a drilling module comprising a drill-bit, wherein the apparatus further comprises: a sensor for measuring one or more parameters relating to the interaction of the drill-bit and the material being drilled; and a sensor for measuring one or more motions of the drill-bit.
An active heterodyne detection system comprises a continuously tuneable laser source (1) emitting infra-red radiation, means (8) to split the infra-red radiation into a first part and a second part, means (4) to provide a frequency shift between the first part and the second part, means (8, 9) to direct the first part of the infra-red radiation to a target (2), means (4) to provide the second part of the infra-red radiation as a local oscillator, means (8, 9) to collect a scattered component of the first part of the infra-red light from the target (2), and means (5) to mix the scattered component and the local oscillator and route them to a detector (3) for heterodyne detection over a continuous spectral range. A method of active heterodyne detection over a continuous spectral range is also disclosed.
G01N 21/49 - Dispersion, c.-à-d. réflexion diffuse dans un corps ou dans un fluide
G01S 17/32 - Systèmes déterminant les données relatives à la position d'une cible pour mesurer la distance uniquement utilisant la transmission d'ondes continues, soit modulées en amplitude, en fréquence ou en phase, soit non modulées
G01S 17/95 - Systèmes lidar, spécialement adaptés pour des applications spécifiques pour la météorologie
H01S 5/34 - Structure ou forme de la région activeMatériaux pour la région active comprenant des structures à puits quantiques ou à superréseaux, p. ex. lasers à puits quantique unique [SQW], lasers à plusieurs puits quantiques [MQW] ou lasers à hétérostructure de confinement séparée ayant un indice progressif [GRINSCH]
H01S 5/024 - Dispositions pour la gestion thermique
The present invention provides a tubular article (10), such as may be used as an oil and gas pipeline, having a longitudinal axis X comprising inner and outer separate strips (12, 14) of spirally wound overlapping material each having a longitudinal axis L and first and second edges (16, 18, 16′, 18′), in which each strip (12, 14) comprises two or more longitudinally extending ridges (20, 22, 20′, 22′), each of which extends along said longitudinally extending axis L in parallel to each other and in which said ridges (20, 22, 20′, 22′) each comprise asymmetric ridges having a leading edge (24, 24′) forming a contact portion (28, 28′) and wherein said leading edges (24, 24′) are each in contact with each other and further comprising a non-contact trailing edge portion (26, 26′) which are spaced from each other by an amount G.
F16L 11/16 - Manches, c.-à-d. tuyaux flexibles en un matériau rigide, p. ex. en métal ou en matériaux plastiques durs faites d'enroulements de bandes ou de lanières profilées
The invention relates to a method and apparatus for reducing speckle noise in a system comprising a sensor for detecting electro-magnetic radiation backscattered from a target, comprising: illuminating the target with a first illuminating beam having a first optical path; illuminating the target with a second illuminating beam having a second optical path different to the first optical path; capturing at the sensor first and second backscattered radiation components associated with respectively the first and second illuminating beams, each of the backscattered radiation components comprising a speckle pattern; and taking a time-averaged measurement of the intensities of the first and second backscattered radiation components; wherein the capturing step is carried out within an integration time t of the sensor, such that the time-averaged intensity measurement results in a decrease in speckle noise present in a signal representing the backscattered radiation.
G01D 5/28 - Moyens mécaniques pour le transfert de la grandeur de sortie d'un organe sensibleMoyens pour convertir la grandeur de sortie d'un organe sensible en une autre variable, lorsque la forme ou la nature de l'organe sensible n'imposent pas un moyen de conversion déterminéTransducteurs non spécialement adaptés à une variable particulière utilisant des moyens optiques, c.-à-d. utilisant de la lumière infrarouge, visible ou ultraviolette avec déviation des rayons lumineux, p. ex. pour une indication optique directe
G02B 27/48 - Systèmes optiques utilisant la granulation produite par laser
wherein the upper load-cell is positioned above the vibration isolation unit and the lower load-cell is positioned between the vibration transmission unit and the drill-bit, and wherein the upper and lower load-cells are connected to a controller in order to provide down-hole closed loop real time control of the oscillator.
wherein the upper load-cell positioned above the vibration isolation unit and the lower load-cell is positioned between the oscillator and the drill-bit wherein the upper and lower load-cells are connected to a controller in order to provide down-hole closed loop real time control of the oscillator.
E21B 44/00 - Systèmes de commande automatique spécialement adaptés aux opérations de forage, c.-à-d. systèmes à fonctionnement autonome ayant pour rôle d'exécuter ou de modifier une opération de forage sans l'intervention d'un opérateur humain, p. ex. systèmes de forage commandés par ordinateurSystèmes spécialement adaptés à la surveillance de plusieurs variables ou conditions de forage
An apparatus for use in resonance enhanced rotary drilling. The apparatus comprising one or both of: (a) a vibration isolation unit; and (b) a vibration transmission unit. The vibration isolation unit and/or the vibration transmission unit typically comprising a spring system comprising two or more frusto-conical springs arranged in series.
E21B 17/07 - Joints télescopiques permettant de faire varier les longueurs de trains de tigesAmortisseurs
E21B 7/24 - Forage utilisant des moyens vibrants ou oscillants, p. ex. des masses déséquilibrées
E21B 44/00 - Systèmes de commande automatique spécialement adaptés aux opérations de forage, c.-à-d. systèmes à fonctionnement autonome ayant pour rôle d'exécuter ou de modifier une opération de forage sans l'intervention d'un opérateur humain, p. ex. systèmes de forage commandés par ordinateurSystèmes spécialement adaptés à la surveillance de plusieurs variables ou conditions de forage
Provided is an apparatus for use in directional drilling, which apparatus comprises: (a) a drill bit; (b) at least one steering actuator capable of exerting a longitudinal force on the drill bit, so as to change the direction of drilling; and/or (c) at least one drill bit steering insert, capable of extending and retracting so as to change the cutting characteristics of the drill bit and thereby change the direction of drilling. Further provided is a method of directional drilling, employing the apparatus of the invention.
Provided is an apparatus for use in directional drilling, which apparatus comprises: (a) a drill bit; (b) at least one steering actuator capable of exerting a longitudinal force on the drill bit, so as to change the direction of drilling; and/or (c) at least one drill bit steering insert, capable of extending and retracting so as to change the cutting characteristics of the drill bit and thereby change the direction of drilling. Further provided is a method of directional drilling, employing the apparatus of the invention.
Provided herein are methods for the assembly of a polynucleic acid sequence that is at least partially carried out on a microfluidic device; methods for the preparation of a library of polynucleic acid sequences; microfluidic devices; methods for designing nucleic acid sequences; methods for planning the assembly of a polynucleic acid sequence from a plurality of nucleic acid sequences; systems comprising components for carrying out these methods; computer programs which, when run on a computer, implements these methods; and computer readable medium or carrier signals encoding such a computer program.
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
C12N 15/66 - Méthodes générales pour insérer un gène dans un vecteur pour former un vecteur recombinant, utilisant le clivage et la ligatureUtilisation de linkers non fonctionnels ou d'adaptateurs, p. ex. linkers contenant la séquence pour une endonucléase de restriction
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
B01L 7/00 - Appareils de chauffage ou de refroidissementDispositifs d'isolation thermique
An active heterodyne detection system comprises a continuously tuneable laser source (1) emitting infra-red radiation, means (8) to split the infra-red radiation into a first part and a second part,, means (4) to provide a frequency shift between the first part and the second part, means (8, 9) to direct the first part of the infra-red radiation to a target (2), means (4) to provide the second part of the infra-red radiation as a local oscillator, means (8, 9) to collect a scattered component of the first part of the infra-red light from the target (2), and means (5) to mix the scattered component and the local oscillator and route them to a detector (3) for heterodyne detection over a continuous spectral range. A method of active heterodyne detection over a continuous spectral range is also disclosed.
G01S 17/95 - Systèmes lidar, spécialement adaptés pour des applications spécifiques pour la météorologie
H01L 23/38 - Dispositifs de refroidissement utilisant l'effet Peltier
H01S 5/024 - Dispositions pour la gestion thermique
H01S 5/34 - Structure ou forme de la région activeMatériaux pour la région active comprenant des structures à puits quantiques ou à superréseaux, p. ex. lasers à puits quantique unique [SQW], lasers à plusieurs puits quantiques [MQW] ou lasers à hétérostructure de confinement séparée ayant un indice progressif [GRINSCH]
An active heterodyne detection system comprises a continuously tuneable laser source (1) emitting infra-red radiation, means (8) to split the infra-red radiation into a first part and a second part,, means (4) to provide a frequency shift between the first part and the second part, means (8, 9) to direct the first part of the infra-red radiation to a target (2), means (4) to provide the second part of the infra-red radiation as a local oscillator, means (8, 9) to collect a scattered component of the first part of the infra-red light from the target (2), and means (5) to mix the scattered component and the local oscillator and route them to a detector (3) for heterodyne detection over a continuous spectral range. A method of active heterodyne detection over a continuous spectral range is also disclosed.
G01S 17/95 - Systèmes lidar, spécialement adaptés pour des applications spécifiques pour la météorologie
G01S 17/32 - Systèmes déterminant les données relatives à la position d'une cible pour mesurer la distance uniquement utilisant la transmission d'ondes continues, soit modulées en amplitude, en fréquence ou en phase, soit non modulées
H01L 23/38 - Dispositifs de refroidissement utilisant l'effet Peltier
H01S 5/024 - Dispositions pour la gestion thermique
H01S 5/34 - Structure ou forme de la région activeMatériaux pour la région active comprenant des structures à puits quantiques ou à superréseaux, p. ex. lasers à puits quantique unique [SQW], lasers à plusieurs puits quantiques [MQW] ou lasers à hétérostructure de confinement séparée ayant un indice progressif [GRINSCH]
Provided is a method for detecting analyte in a sample, which method comprises: (a) contacting the sample with a peptide nucleic acid (PNA) probe; (b) performing an electrochemical impedance spectrometry (EIS) measurement on the sample; (c) determining the presence, absence, quantity and/or identity of the analyte from the EIS measurement; wherein the analyte comprises nucleic acid; and wherein the quantity of analyte in the sample when the sample is taken is substantially the same as the quantity of analyte in the sample when the sample is subjected to the EIS measurement.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
G01N 27/02 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
The present invention provides a tubular article (10),such as may be used as an oil and gas pipeline, having a longitudinal axis X comprising inner and outer separate strips (12,14) of spirally wound overlapping material each having a longitudinal axis L and first and second edges (16, 18, 16', 18'), in which each strip (12,14) comprises two or more longitudinally extending ridges (20, 22, 20', 22'), each of which extends along said longitudinally extending axis L in parallel to each other and in which said ridges (20, 22, 20', 22') each comprise asymmetric ridges having a leading edge (24, 24') forming a contact portion (28, 28') and wherein said leading edges (24, 24') are each in contact with each other and further comprising a non-contact trailing edge portion (26, 26') which are spaced from each other by an amount G.
F16L 11/16 - Manches, c.-à-d. tuyaux flexibles en un matériau rigide, p. ex. en métal ou en matériaux plastiques durs faites d'enroulements de bandes ou de lanières profilées
23.
BINDING INHIBITORS OF THE BETA.TRANSDUCIN REPEAT - CONTAINING PROTEIN
The present invention relates to compounds which bind to Beta Trans-ducin repeat-containing protein (PTrCP), and modulate the activity of l3TrCP. In particular, the invention relates to compounds which demonstrate optimised binding to PTrCP. The invention also relates to pharmaceutical compositions comprising such compounds and the use of such compounds as medicaments, specifically for the treatment of disorders associated with aberrant protein degradation, such as cancer. The preferred binding inhibitors are peptides derived from the motive DSGXXS, e.g. DEGFWE, DDGFWD and Succinyl-EGFWE.
C07K 7/06 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 5 à 11 amino-acides
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
24.
Apparatus for and method of manufacturing helically wound structures
An apparatus (50) for and method of manufacturing helically wound tubular structures (116) includes a rotating faceplate (74) upon which are mounted a plurality of diameter defining rollers (78) which, in operation, cause a strip material (80) to be plastically deformed into a helical winding which may be lain down in abutting or self-overlapping relationship to form said tubular structure (116).
Provided is an apparatus for testing a resonance enhanced rotary drilling module, which apparatus comprises: (i) a resonance enhanced rotary drilling module comprising an oscillator; (ii) a fixed frame for fixing the apparatus to a base surface; (iii) a movable frame for moving the rotary drilling module in an axial direction relative to a sample; (iv) a means for generating relative rotary motion between the drilling module and a sample; and (v) a torsion restraint unit for reducing the torsional loading on the oscillator.
Provided is apparatus for use in resonance enhanced rotary drilling, which apparatus comprises: (i) an upper load-cell for measuring static and dynamic axial loading; (ii) a vibration isolation unit; (iii) optionally an oscillator back mass; (iv) an oscillator for applying axial oscillatory loading to the rotary drill-bit; (v) a vibration transmission unit; (vi) a lower load-cell for measuring static and dynamic axial loading; (vii) a drill-bit connector; and (viii) a drill-bit, wherein the upper load-cell is positioned above the vibration isolation unit and the lower load-cell is positioned between the vibration transmission unit and the drill-bit, and wherein the upper and lower load-cells are connected to a controller in order to provide down-hole closed loop real time control of the oscillator.
Provided is an apparatus for use in resonance enhanced rotary drilling, which apparatus comprises one or both of: (a) a vibration isolation unit; and (b) a vibration transmission unit. typically wherein the vibration isolation unit and/or the vibration transmission unit comprise a spring system comprising two or more frusto-conical springs arranged in series.
Provided is apparatus for use in resonance enhanced rotary drilling, which apparatus comprises: • (i) an upper load-cell for measuring static and dynamic axial loading; • (ii) a vibration isolation unit; • (iii) optionally an oscillator back mass; • (iv) an oscillator for applying axial oscillatory loading to the rotary drill-bit; • (v) a vibration transmission unit; • (vi) a lower load-cell for measuring static and dynamic axial loading; • (vii) a drill-bit connector; and • (viii) a drill-bit, wherein the upper load-cell is positioned above the vibration isolation unit and the lower load-cell is positioned between the vibration transmission unit and the drill-bit, and wherein the upper and lower load-cells are connected to a controller in order to provide down-hole closed loop real time control of the oscillator.
Provided is an apparatus for use in resonance enhanced rotary drilling, which apparatus comprises one or both of: (a) a vibration isolation unit; and (b) a vibration transmission unit. typically wherein the vibration isolation unit and/or the vibration transmission unit comprise a spring system comprising two or more frusto-conical springs arranged in series.
The present invention provides a method for the assembly of a polynucleic acid sequence from a plurality of nucleic acid sequences in which the polynucleic acid sequence is of a formula Nn+1, in which N represents a nucleic acid sequence and where n is 1 or greater than 1 and each N may be the same or a different nucleic acid sequence, in which the method comprises: (i) providing a first nucleic acid sequence N1 which has an oligonucleotide linker sequence L13' at the 3'-end of the nucleic acid sequence; (ii) providing a second nucleic acid sequence N2 which optionally has an oligonucleotide linker sequence L23 at the 3'-end of the nucleic acid sequence and which has an oligonucleotide linker sequence L25 at the 5'-end of the nucleic acid sequence, wherein the 5'-end linker sequence L25 of nucleic acid sequence N2 is complementary to the 3'-end linker sequence L13 of nucleic acid sequence N1; (iii) optionally providing one or more additional nucleic acid sequences N, wherein nucleic acid sequence N2 has an oligonucleotide linker sequence L23at the 3'-end of the nucleic acid sequence, and wherein said one or more additional nucleic acid sequences N comprises a terminal additional nucleic acid sequence NZ, and wherein each additional nucleic acid sequence N has an oligonucleotide linker sequence at its 3'-end, wherein said terminal additional nucleic acid sequence NZ optionally lacks an oligonucleotide linker sequence at its 3'-end and wherein each additional nucleic acid sequence N has an oligonucleotide linker sequence at its 5'-end, wherein for the first additional nucleic acid sequence N3 the 5'-end linker sequence L35 is complementary to the 3'-end linker sequence L23' of nucleic acid sequence N2 and for each second and subsequent additional nucleic acid sequence N the 5'-end linker sequence is complementary to the 3'-end linker sequence of the respective preceding additional nucleic acid sequence; and (iv) ligating said nucleic acid sequences to form said polynucleic acid sequence; wherein at least step (iv) is carried out on a microfluidic device.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
32.
A METHOD FOR ASSEMBLING A POLYNUCLEIC ACID ON A MICROFLUIDIC DEVICE
The present invention provides a method for the assembly of a polynucleic acid sequence from a plurality of nucleic acid sequences in which the polynucleic acid sequence is of a formula Nn+1, in which N represents a nucleic acid sequence and where n is 1 or greater than 1 and each N may be the same or a different nucleic acid sequence, in which the method comprises: (i) providing a first nucleic acid sequence N1 which has an oligonucleotide linker sequence L13' at the 3'-end of the nucleic acid sequence; (ii) providing a second nucleic acid sequence N2 which optionally has an oligonucleotide linker sequence L23 at the 3'-end of the nucleic acid sequence and which has an oligonucleotide linker sequence L25 at the 5'-end of the nucleic acid sequence, wherein the 5'-end linker sequence L25 of nucleic acid sequence N2 is complementary to the 3'-end linker sequence L13 of nucleic acid sequence N1; (iii) optionally providing one or more additional nucleic acid sequences N, wherein nucleic acid sequence N2 has an oligonucleotide linker sequence L23at the 3'-end of the nucleic acid sequence, and wherein said one or more additional nucleic acid sequences N comprises a terminal additional nucleic acid sequence NZ, and wherein each additional nucleic acid sequence N has an oligonucleotide linker sequence at its 3'-end, wherein said terminal additional nucleic acid sequence NZ optionally lacks an oligonucleotide linker sequence at its 3'-end and wherein each additional nucleic acid sequence N has an oligonucleotide linker sequence at its 5'-end, wherein for the first additional nucleic acid sequence N3 the 5'-end linker sequence L35 is complementary to the 3'-end linker sequence L23' of nucleic acid sequence N2 and for each second and subsequent additional nucleic acid sequence N the 5'-end linker sequence is complementary to the 3'-end linker sequence of the respective preceding additional nucleic acid sequence; and (iv) ligating said nucleic acid sequences to form said polynucleic acid sequence; wherein at least step (iv) is carried out on a microfluidic device.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
C07H 21/00 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
C40B 40/06 - Bibliothèques comprenant des nucléotides ou des polynucléotides ou leurs dérivés
C40B 50/00 - Procédés de création de bibliothèques, p. ex. synthèse combinatoire
C40B 50/06 - Procédés biochimiques, p. ex. utilisant des enzymes ou des micro-organismes viables entiers
The use of compounds or pharmaceutically acceptable derivatives thereof which are ubiquitin modulators, in methods of treating cancer, inflammatory diseases, neurodegenerative diseases and/or cardiovascular diseases is described.
A61K 31/34 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à cinq chaînons avec un oxygène comme seul hétéro-atome d'un cycle, p. ex. isosorbide
A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
A61P 9/00 - Médicaments pour le traitement des troubles du système cardiovasculaire
The present application relates to a method of assaying ubiquitination in a sample by combining ubiquitin together with a substrate in a sample containing UBEl, UbcH3, Skp2-isoform 1, Skpl, Cull, Rbxl, Cksl, CDK2 and Cyclin El under conditions suitable for ubiquitination to take place, exposing the sample to a labelled binding partner which is specific for the ubiquitin, and measuring the amount of ubiquitin bound to the substrate.
C12Q 1/37 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase faisant intervenir une peptidase ou une protéinase
G01N 33/542 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec formation d'un complexe immunologique en phase liquide avec inhibition stérique ou modification du signal, p. ex. extinction de fluorescence
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
The present invention related to a method of assaying ubiquitination in a sample by combining ubiquitin and two or more of El, E2, E3 and a substrate protein in a sample under conditions suitable for ubiquitination to take place, exposing the sample with a labelled binding partner which is specific for the ubiquitin and measuring the amount of labelled ubiquitin bound to any one of the components in the sample, wherein one or more of the components in the sample comprises an immobilisation tag which facilitates its immobilisation onto a solid surface.
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
The present invention is directed to assays to measure the level of poly-ubiquitin present in a sample. The invention also relates to assays to measure the activity of ubiquitination enzymes, the use of such assays in screening for agents that modulate this activity and kits containing the components required to perform this assays.
G01N 33/573 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour enzymes ou isoenzymes
C12Q 1/25 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des enzymes qui ne peuvent pas être classées dans les groupes
This invention relates to structures for mounting LEDs, said structures being suitable for use in the manufacture of light guide devices. This invention also relates to light guide devices comprising said structures and methods of manufacture of the aforementioned. The light guide devices are suitable for use in a range of applications, particularly in connection with the backlighting of displays, for example, liquid crystal displays.
G02B 6/00 - Guides de lumièreDétails de structure de dispositions comprenant des guides de lumière et d'autres éléments optiques, p. ex. des moyens de couplage
F21V 8/00 - Utilisation de guides de lumière, p. ex. dispositifs à fibres optiques, dans les dispositifs ou systèmes d'éclairage
38.
ENCAPSULATED LED ARRAY AND EDGE LIGHT GUIDE DEVICE COMPRISING SUCH AN LED ARRAY
This invention relates to structures for mounting LEDs, said structures being suitable for use in the manufacture of light guide devices. This invention also relates to light guide devices comprising said structures and methods of manufacture of the aforementioned. The light guide devices are suitable for use in a range of applications, particularly in connection with the backlighting of displays, for example, liquid crystal displays.
G02B 6/00 - Guides de lumièreDétails de structure de dispositions comprenant des guides de lumière et d'autres éléments optiques, p. ex. des moyens de couplage
F21V 8/00 - Utilisation de guides de lumière, p. ex. dispositifs à fibres optiques, dans les dispositifs ou systèmes d'éclairage
H01L 33/54 - Encapsulations ayant une forme particulière
H01L 33/62 - Dispositions pour conduire le courant électrique vers le corps semi-conducteur ou depuis celui-ci, p.ex. grille de connexion, fil de connexion ou billes de soudure
The application is directed to the impedimetric determination of analyte binding, eg. DNA hybridisation using electrochemical impedance spectrometry (EIS). In one embodiment, simultaneous multi-frequency excitation is used, followed by FFT. In another, a differential method is used to monitor the rate of change of EIS variables, especially the electron transfer resistance, Ret. Combining EIS with labels allows the multiplex determination of a plurality of analytes. Also, kinetic monitoring of enzyme activity, especially of protease in wound healing, becomes possible.
G01N 27/02 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance
G01N 33/487 - Analyse physique de matériau biologique de matériau biologique liquide
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
This invention relates to light guide devices and methods of manufacture. The light guide device is suitable for use in a range of applications, particularly in connection with the backlighting of displays, for example, liquid crystal displays.
G02B 6/00 - Guides de lumièreDétails de structure de dispositions comprenant des guides de lumière et d'autres éléments optiques, p. ex. des moyens de couplage
Provided is a microfluidic mixing system comprising a loop system for transferring one or more fluids, wherein the loop system comprises a plurality of sub loops, each sub loop formed from one or more common channels shared with at least one other sub loop and completed by an outer channel portion that is not shared by any other sub loop, and wherein the outer channel portion of each sub loop comprises one or more valves such that the sub loop is capable of isolation from all other sub loops and each common channel comprises one or more valves such that the common channel is capable of isolation from the remainder of the loop system, and wherein one or more sub loops in the system comprise valves that are configured to enable peristaltic mixing.
Provided is a microfluidic or nanofluidic apparatus which comprises: (a) a reservoir for one or more fluids; (b) a mixing device configured to mix the one or more fluids within the reservoir; and (c) a microfluidic or nanofluidic device in fluid connection with the reservoir; wherein the reservoir is suitable for containing a total volume of fluid of from 100 microliters to 100 milliliters. Also provided is a method of manufacturing the apparatus and the use of the apparatus to detect an analyte in a fluid.
A notation enhancement system and method are disclosed. The system comprises a parsing unit, a reasoning unit and a data repository. The data repository is arranged to store data on at least components of notations of a first notation type and a second notation type and linking said components of the first notation type to a corresponding notation of the second notation type. The parsing unit is arranged to parse computer program source code to identify notations of the first type in said source code. The reasoning unit is arranged to communicate with the parsing unit and the data repository and is responsive upon identification of a notation of the first type by the parsing unit to construct a notation of the second type from one or more of said components in the data repository and insert said constructed notation in the computer program source code, the constructed notation corresponding to the identified notation of the first type.
A method for controlling a resonance enhanced rotary drill comprising a rotary drill bit and an oscillator for applying axial oscillatory loading to the rotary drill bit, the method comprising: controlling frequency (f) of the oscillator in the resonance enhanced rotary drill whereby the frequency (f) is maintained in the range (D2 Us/(8000pAm))1/2 = f = Sf(D2 Us/(8000pAm))1/2 where D is diameter of the rotary drill bit, Us is compressive strength of material being drilled, A is amplitude of vibration, m is vibrating mass, and Sf is a scaling factor greater than 1; and controlling dynamic force (Fd) of the oscillator in the resonance enhanced rotary drill whereby the dynamic force (Fd) is maintained in the range [(p/4)D2 effUs] = Fd = SFd[(p/4)D2 effUs] where Deff is an effective diameter of the rotary drill bit, Us is a compressive strength of material being drilled, and SFd is a scaling factor greater than 1, wherein the frequency (f) and the dynamic force (Fd) of the oscillator are controlled by monitoring signals representing the compressive strength (Us) of the material being drilled and adjusting the frequency (f) and the dynamic force (Fd) of the oscillator using a closed loop real-time feedback mechanism according to changes in the compressive strength (Us) of the material being drilled.
A method for controlling a resonance enhanced rotary drill comprising a rotary drill bit and an oscillator for applying axial oscillatory loading to the rotary drill bit, the method comprising: controlling frequency (f) of the oscillator in the resonance enhanced rotary drill whereby the frequency (f) is maintained in the range (D2 Us/(8000πAm))1/2 ≤ f ≤ Sf(D2 Us/(8000πAm))1/2 where D is diameter of the rotary drill bit, Us is compressive strength of material being drilled, A is amplitude of vibration, m is vibrating mass, and Sf is a scaling factor greater than 1; and controlling dynamic force (Fd) of the oscillator in the resonance enhanced rotary drill whereby the dynamic force (Fd) is maintained in the range [(π/4)D2effUs] ≤ Fd ≤ SFd[(π/4)D2effUs] where Deff is an effective diameter of the rotary drill bit, Us is a compressive strength of material being drilled, and SFd is a scaling factor greater than 1, wherein the frequency (f) and the dynamic force (Fd) of the oscillator are controlled by monitoring signals representing the compressive strength (Us) of the material being drilled and adjusting the frequency (f) and the dynamic force (Fd) of the oscillator using a closed loop real-time feedback mechanism according to changes in the compressive strength (Us) of the material being drilled.
The present invention provides a loading element for reversibly coupling a microfluidic or nanofluidic cartridge to a processing apparatus wherein the loading element comprises: (a) a first connector part comprising a first set of air inlet ports and a first set of air outlet ports; (b) a second connector part comprising a second set of air inlet ports and a second set of air outlet ports; and (c) a guide part configured to guide the cartridge into reversible coupling with the loading element.
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
Provided is a processing apparatus for enabling a plurality of processes to be conducted on a sample within a microfluidic or nanofluidic cartridge, the apparatus comprising: a) a plurality of processing modules for facilitating the processes conducted on the sample within the cartridge; b) a coupling means for reversibly coupling the cartridge to the apparatus; c) a transport means capable of bringing the cartridge coupled to the coupling means into communication with each of the processing modules; wherein the plurality of processing modules includes a component isolation module capable of facilitating a separation process within the cartridge, a manipulator module capable of facilitating the movement of fluids within the cartridge; and an optical module capable of interacting optically with the cartridge.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
An automatic debugging system and method for automatically identifying a source of a run- time error in a computer system is disclosed. The debugging system comprises a static analysis system, an instrumentation system and a post-execution analysis system. The static analysis system is arranged to generate static analysis data on computer program code for the computer system, the static analysis data including information on possible behaviours of the computer program code when executed. The instrumentation system is arranged to instrument the computer program code by inserting marker triggers into the computer program code, the marker triggers being arranged to generate a marker associated with each of a number of predetermined points in the computer program code that would be reached during execution of the computer program code, each marker being uniquely identifiable and the points being determined in dependence on the static analysis data. The post execution analysis system is arranged to process data on a run-time error produced by execution of said instrumented computer program code, the generated markers and the static analysis data to identify the source of the run-time error.
This invention relates to film layer which is suitable for use in a light guide plate and methods of forming said film layer and light guide plate. The invention also relates to the light guide plate and light guide devices made therefrom. The film and light guide plate are suitable for use in a range of applications, particularly in connection with the backlighting of displays, for example, liquid crystal displays.
G02F 1/13 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p. ex. commutation, ouverture de porte ou modulationOptique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur basés sur des cristaux liquides, p. ex. cellules d'affichage individuelles à cristaux liquides
G02F 1/1335 - Association structurelle de cellules avec des dispositifs optiques, p. ex. des polariseurs ou des réflecteurs
F21V 7/22 - Réflecteurs pour sources lumineuses caractérisés par les matériaux, traitements de surface ou revêtements
B41M 1/12 - Impression au stencilImpression à trame de soie
This invention relates to light guide devices and methods of manufacture. The light guide device is suitable for use in a range of applications, particularly in connection with the backlighting of displays, for example, liquid crystal displays.
G02B 6/00 - Guides de lumièreDétails de structure de dispositions comprenant des guides de lumière et d'autres éléments optiques, p. ex. des moyens de couplage
This invention relates to light guide devices and methods of manufacture. The light guide device is suitable for use in a range of applications, particularly in connection with the backlighting of displays, for example, liquid crystal displays.
G02B 6/00 - Guides de lumièreDétails de structure de dispositions comprenant des guides de lumière et d'autres éléments optiques, p. ex. des moyens de couplage
Provided is a flow control element for a microfluidic or nanofluidic device, comprising: a) a fluid source; and b) a flow restriction component; wherein the flow restriction component is situated downstream from the fluid source, and the flow restriction component has a hydrodynamic resistance at least 5 times higher than the hydrodynamic resistance of the device. Also provided is an apparatus comprising at least one flow control element and further comprising a microfluidic or nanofluidic device. Additionally provided is the use of the flow control element or apparatus. Further provided is a method of regulating the flow rate of a fluid entering or within a microfluidic or nanofluidic device, which method comprises altering the pressure applied to a fluid within a fluid source of a flow control element or apparatus as defined in any preceding claim.
A harness (100) for an animal comprises a flexible member (101 ) for fitting to and against a part of the animal. Electrodes (105_1, 105_2, 1O5_3, 105_5, 105_6, 105_7) located at predetermined locations on the flexible member (101 ) are provided. At least one guide means (not shown) is also provided for positioning the flexible member (101 ) relative to at least one anatomical part of the animal such that the electrodes (105_1 to 1O5_8) are located at predetermined anatomical zones on and against the animal.
The invention provides methods for reversibly inhibiting stem cell differentiation wherein a compound of formula (I) is contacted with a stem cell. The invention further provides a method for preparing a culture medium, a culture medium supplement and a composition comprising a compound of formula (I).
A winding apparatus for and method of manufacturing helically wound tubular structures (116) includes a rotating inner faceplate (74) upon which are mounted a forming station for forming a supply of strip material before it is wound into a desired structure and a plurality of inner supports in the form of rollers (110) mounted for rotation about an axis and with said inner faceplate and a plurality of outer driven rollers (92) provided on an outer faceplate (118). The inner rollers (110) are mounted for radial movement relative to the inner faceplate (74). In operation, the inner rollers (110) act to support an inner portion S1 of strip material wound thereon whilst allowing it to be supplied from an inner diameter thereof to said forming station and the outer rollers (92) act to support an outer portion S2 of said strip. Said outer rollers are driven as and when necessary to transfer material to the inner portion S1 and the radial position of the inner rollers increases as strip material is consumed from an inner diameter, thereby to maintain support of the strip supply regardless of the amount that has been consumed.
B21C 37/12 - Fabrication de tubes ou de tuyaux métalliques à jonction hélicoïdale
B21C 49/00 - Dispositifs pour accumuler temporairement les matériaux
B29C 53/68 - Enroulement et assemblage, p. ex. enroulement en spirale hélicoïdal en utilisant des surfaces de formage internes, p. ex. des mandrins avec un élément d'alimentation d'enroulement rotatif
B65H 20/26 - Mécanismes pour faire avancer les bandes vers les bobines ou depuis l'intérieur de celles-ci
56.
APPARATUS FOR AND METHOD OF MANUFACTURING A HELICALLY WOUND TUBULAR STRUCTURE
A winding apparatus for and method of manufacturing helically wound tubular structures (116) includes a rotating faceplate (74) upon which are mounted a forming station for forming a supply of strip material before it is wound into a desired structure, a plurality of inner supports in the form of rollers (110) mounted for rotation about an axis and with said inner faceplate and a plurality of outer driven rollers (92) provided on an outer faceplate (118). In operation, the inner rollers act to support an inner portion S1 of strip material wound thereon whilst allowing it to be supplied from an inner diameter thereof to said forming station and the outer rollers (92) act to support an outer portion S2 of said strip. Said outer rollers are driven as and when necessary to transfer material to the inner portion S1.
B21C 37/12 - Fabrication de tubes ou de tuyaux métalliques à jonction hélicoïdale
B21C 49/00 - Dispositifs pour accumuler temporairement les matériaux
B29C 53/68 - Enroulement et assemblage, p. ex. enroulement en spirale hélicoïdal en utilisant des surfaces de formage internes, p. ex. des mandrins avec un élément d'alimentation d'enroulement rotatif
B65H 20/26 - Mécanismes pour faire avancer les bandes vers les bobines ou depuis l'intérieur de celles-ci
57.
A WINDING APPARATUS FOR AND METHOD OF MANUFACTURING HELICALLY WOUND TUBULAR STRUCTURES
A winding apparatus for and method of manufacturing helically wound tubular structures (116) includes: a rotating inner faceplate (74) upon which are mounted a forming station for forming a supply of strip material before it is wound into a desired structure; a plurality of inner supports in the form of inner support rollers (110) mounted for radial displacement and rotation about an axis; an outer faceplate (118) having a plurality of outer support rollers (92) mounted for radial displacement and rotation about an axis. In operation, the inner support rollers act to support an inner portion S1 of strip material wound thereon whilst allowing it to be supplied from an inner diameter thereof to said forming station and the outer support rollers (92) act to support an outer portion S2 of said strip. The inner support rollers (110) and outer support rollers (92) are adapted to move radially to maintain support of said strip material as it is consumed.
An apparatus (50) for and method of manufacturing helically wound tubular structures (116) includes coaxial rotating face plates (74, 89, 97), capable of rotation at different angular speeds. A plurality of forming rollers (76) and diameter defining rollers (78) are mounted on the inner faceplate (74, 89), which, in operation, cause a strip material (80) to be plastically deformed into a helical winding which may be lain down in abutting or self -overlapping relationship to form said tubular structure (116). A plurality of support rollers are mounted in a circle on the inner faceplate (74, 89) at a distance from the axis exceeding that of the outermost forming roller and serve to support the stock of strip material.
B21C 37/12 - Fabrication de tubes ou de tuyaux métalliques à jonction hélicoïdale
B21C 49/00 - Dispositifs pour accumuler temporairement les matériaux
B29C 53/68 - Enroulement et assemblage, p. ex. enroulement en spirale hélicoïdal en utilisant des surfaces de formage internes, p. ex. des mandrins avec un élément d'alimentation d'enroulement rotatif
B65H 20/26 - Mécanismes pour faire avancer les bandes vers les bobines ou depuis l'intérieur de celles-ci
59.
TITANIUM COMPOSITE ELECTRODES AND METHODS THEREFORE
The present invention provides composite electrodes that comprise a titanium metal filler and a polymeric material. Advantageously the composite electrodes of the present invention do not suffer from the problems of carbon degradation, are thermally stable, are easily shaped, which demonstrate high power densities and which are relatively inexpensive to produce.
The present invention provides a method for the assembly of a polynucleic acid sequence from a plurality of nucleic acid sequences in which the polynucleic acid sequence is of a formula Nn+ 1, in which N represents a nucleic acid sequence and where n is 1 or greater than 1 and each N may be the same or a different nucleic acid sequence, in which the method comprises: (i) providing a first nucleic acid sequence N1 which has an oligonucleotide linker sequence L13 at the 3'-end of the nucleic acid sequence; (ii) providing a second nucleic acid sequence N2 which optionally has an oligonucleotide linker sequence L23' at the 3'-end of the nucleic acid sequence and which has an oligonucleotide linker sequence L25' at the 5 '-end of the nucleic acid sequence, wherein the 5' -end linker sequence L25' of nucleic acid sequence N2 is complementary to the 3'-end linker sequence L13' of nucleic acid sequence N1; (iii) optionally providing one or more additional nucleic acid sequences N, wherein nucleic acid sequence N2 has an oligonucleotide linker sequence L23' at the 3 '-end of the nucleic acid sequence, and wherein said one or more additional nucleic acid sequences N comprises a terminal additional nucleic acid sequence NZ, and wherein each additional nucleic acid sequence N has an oligonucleotide linker sequence at its 3'-end, wherein said terminal additional nucleic acid sequence NZ optionally lacks an oligonucleotide linker sequence at its 3'-end and wherein each additional nucleic acid sequence N has an oligonucleotide linker sequence at its 5'-end, wherein for the first additional nucleic acid sequence N3 the 5 '-end linker sequence L35' is complementary to the 3 '-end linker sequence L23' of nucleic acid sequence N2 and for each second and subsequent additional nucleic acid sequence N the 5 '-end linker sequence is complementary to the 3 '-end linker sequence of the respective preceding additional nucleic acid sequence; and (iv) ligating said nucleic acid sequences to form said polynucleic acid sequence.
The present invention provides a method for the assembly of a polynucleic acid sequence from a plurality of nucleic acid sequences in which the polynucleic acid sequence is of a formula N n+ 1, in which N represents a nucleic acid sequence and where n is 1 or greater than 1 and each N may be the same or a different nucleic acid sequence, in which the method comprises: (i) providing a first nucleic acid sequence N1 which has an oligonucleotide linker sequence L13 at the 3'-end of the nucleic acid sequence; (ii) providing a second nucleic acid sequence N2 which optionally has an oligonucleotide linker sequence L23' at the 3'-end of the nucleic acid sequence and which has an oligonucleotide linker sequence L25' at the 5 '-end of the nucleic acid sequence, wherein the 5' -end linker sequence L2' of nucleic acid sequence N2 is complementary to the 3'-end linker sequence L1' of nucleic acid sequence N1; (iii) optionally providing one or more additional nucleic acid sequences N, wherein nucleic acid sequence N2 has an oligonucleotide linker sequence L2' at the 3 '-end of the nucleic acid sequence, and wherein said one or more additional nucleic acid sequences N comprises a terminal additional nucleic acid sequence NZ, and wherein each additional nucleic acid sequence N has an oligonucleotide linker sequence at its 3'-end, wherein said terminal additional nucleic acid sequence NZ optionally lacks an oligonucleotide linker sequence at its 3'-end and wherein each additional nucleic acid sequence N has an oligonu-cleotide linker sequence at its 5'-end, wherein for the first additional nucleic acid sequence N3 the 5 '-end linker sequence L35' is complementary to the 3 '-end linker sequence L2' of nucleic acid sequence N2 and for each second and subsequent additional nucleic acid sequence N the 5 '-end linker sequence is complementary to the 3 '-end linker sequence of the respective preceding additional nucleic acid sequence; and (iv) ligating said nucleic acid sequences to form said polynucleic acid sequence.
Provided is a method for the calibration and/or control of an assay for an analyte, wherein the calibration and/or control method comprises at least; (a) a first calibration and/or control process for calibration and/or control of a first assay process or assay sub-process; and (b) a second calibration and/or control process for calibration and/or control of a second assay process or assay sub-process; wherein the analyte is employed in either the first or the second calibration and/or control process, but is not employed in the other calibration and/or control process, and wherein the calibration and/or control process not employing the analyte is integrated with the assay, and wherein: the first calibration and/or control process is for calibration and/or control of an assay process, and the second calibration and/or control process is for calibration and/or control of a sub-process of the assay process; or wherein the first and second calibration and/or control processes are for calibration and/or control of two different assay processes and/or sub-processes from different assay processes.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
A quadrature oscillator circuit (300) comprising first and second oscillator stages (301, 303), each of said first and second oscillator stages having a controllable amplitude, an output (309, 311, 321, 323) of each of said first and second oscillator stages (301, 303) being fed back via an automatic amplitude control circuit (319,325) to control the gain of each cascaded oscillator circuit (301, 303).
H03B 27/00 - Générateurs fournissant plusieurs oscillations de même fréquence, mais de phases différentes, autres qu'en simple opposition de phase
H03L 5/00 - Commande automatique de la tension, du courant ou de la puissance
H03B 5/12 - Éléments déterminant la fréquence comportant des inductances ou des capacités localisées l'élément actif de l'amplificateur étant un dispositif à semi-conducteurs
64.
METHOD AND APPARATUS FOR GENERATING A SWITCHING WAVEFORM
A switching waveform is generated for driving LED chains for a LCD backlight. The spectral energy of the waveform is distributed by modulating (305) a switching waveform having a desired brightness level with the output of a synthesiser (301) to output (307) a switching waveform in which a temporal characteristic, such as transition timing of a PWM waveform or the pattern of a PDM waveform, is modified to spread its spectrum more evenly with lower harmonic amplitudes to drive (309) a LED array (311) used to backlight a LCD display.
G09G 3/34 - Dispositions ou circuits de commande présentant un intérêt uniquement pour l'affichage utilisant des moyens de visualisation autres que les tubes à rayons cathodiques pour la présentation d'un ensemble de plusieurs caractères, p. ex. d'une page, en composant l'ensemble par combinaison d'éléments individuels disposés en matrice en commandant la lumière provenant d'une source indépendante
H05B 33/08 - Circuits pour faire fonctionner des sources lumineuses électroluminescentes
65.
CIRCUITS FOR GENERATING A CURRENT SINK AND A CURRENT REFERENCE AND A METHOD FOR GENERATING A CURRENT SINK
A current sink circuit (200) comprises a plurality of current sinks (213_1, 213_2, 213_3, 213_4) connected in parallel. Each of the plurality of current sinks (213_1, 213_2, 213_3, 213_4) are connected to a switch (211_1, 211_2, 211_3, 211_4) each of the plurality of current sinks (213_1, 213_2, 213_3, 213_4) are switched to output a first current. The circuit (200) further comprises a summing node (215) for outputting a second current, second current being a sum of the plurality of the first currents.
H03K 17/687 - Commutation ou ouverture de porte électronique, c.-à-d. par d'autres moyens que la fermeture et l'ouverture de contacts caractérisée par l'utilisation de composants spécifiés par l'utilisation, comme éléments actifs, de dispositifs à semi-conducteurs les dispositifs étant des transistors à effet de champ
The brightness of a LCD backlight, comprising a plurality of LEDs or LED chains (221_1 to 221_n), is controlled by a processor (203) for calculating the number of LEDs of a plurality of LEDs to be illuminated for a determined brightness and selecting the calculated number of LEDs or LED chains to form a spatial distribution pattern; and drivers (219_1 to 219_n) for illuminating the calculated number of LEDs in a random or pseudo-random sequence.
G09G 3/34 - Dispositions ou circuits de commande présentant un intérêt uniquement pour l'affichage utilisant des moyens de visualisation autres que les tubes à rayons cathodiques pour la présentation d'un ensemble de plusieurs caractères, p. ex. d'une page, en composant l'ensemble par combinaison d'éléments individuels disposés en matrice en commandant la lumière provenant d'une source indépendante
This invention relates to a light guide plate and methods of manufacture. The light guide plate is suitable for use in a range of applications, particularly those which require backlighting for display units, for example, liquid crystal displays. The light guide plate comprises a combination of light guide layers and one or more scattering features.
The present invention provides a convenient process for making lithium-containing transition metal sulfides involving heating at least one transition metal sulfide with a lithium-containing compound, wherein the lithium-containing compound is selected from one or more of lithium oxide, lithium sulfate, lithium carbonate, anhydrous lithium hydroxide, lithium hydroxide monohydrate, lithium oxalate, lithium nitrate, and any material that is a precursor for any of these lithium-containing compounds.
H01M 4/58 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs de composés inorganiques autres que les oxydes ou les hydroxydes, p. ex. sulfures, séléniures, tellurures, halogénures ou LiCoFyEmploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs de structures polyanioniques, p. ex. phosphates, silicates ou borates
69.
LITHIUM CONTAINING TRANSITION METAL SULFIDE COMPOUNDS
The present invention provides compositions comprising at least one lithium-containing transition metal sulfide and carbon, wherein particles of the carbon are dispersed at the microscopic level on individual particles of the lithium-containing transition metal sulfide.
H01M 4/58 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs de composés inorganiques autres que les oxydes ou les hydroxydes, p. ex. sulfures, séléniures, tellurures, halogénures ou LiCoFyEmploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs de structures polyanioniques, p. ex. phosphates, silicates ou borates
The present invention provides a convenient process for making lithium-containing transition metal sulfides involving heating at least one transition metal sulfide with lithium sulfate or any material that is a precursor for lithium sulfate, under reducing reaction conditions, wherein the oxidation state of the transition metal is not reduced during the reaction process.
H01M 4/58 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs de composés inorganiques autres que les oxydes ou les hydroxydes, p. ex. sulfures, séléniures, tellurures, halogénures ou LiCoFyEmploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs de structures polyanioniques, p. ex. phosphates, silicates ou borates
The present invention provides a convenient process for making lithium sulfide involving heating one or more lithium-containing compounds and sulfur, wherein the heating step is performed at a temperature of 600 to 1500°C.
H01M 4/58 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs de composés inorganiques autres que les oxydes ou les hydroxydes, p. ex. sulfures, séléniures, tellurures, halogénures ou LiCoFyEmploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs de structures polyanioniques, p. ex. phosphates, silicates ou borates
Light guide devices comprising an intermediate layer of low refractive index between higher refractive index elements are described. The light guide devices are suitable for use in backlights.
The present invention provides a polymeric article formed from oriented polymeric strands (52) made using a hot compaction process and in which layers of said strands are lain one-on-top of the other and the bond therebetween is improved by the inclusion of a plurality of particles (108) spread across the confronting surfaces prior to bonding. The particles have a higher melting point than the oriented polymeric strands. The particles may be embedded in a polymer layer (54) prior to insertion between said surfaces.
B29C 43/00 - Moulage par pressage, c.-à-d. en appliquant une pression externe pour faire couler la matière à moulerAppareils à cet effet
B29C 70/64 - Façonnage de matières composites, c.-à-d. de matières plastiques comprenant des renforcements, des matières de remplissage ou des parties préformées, p. ex. des inserts comprenant uniquement des matières de remplissage les matières de remplissage ayant une influence sur les caractéristiques de surface du matériau, p. ex. en se concentrant près de la surface ou en étant enfoncées de force dans la surface
B29C 37/00 - Éléments constitutifs, détails, accessoires ou opérations auxiliaires non couverts par le groupe ou
B32B 5/16 - Produits stratifiés caractérisés par l'hétérogénéité ou la structure physique d'une des couches caractérisés par le fait qu'une des couches est formée de particules, p. ex. de copeaux, de fibres hachées, de poudre
B32B 27/20 - Produits stratifiés composés essentiellement de résine synthétique caractérisée par l'emploi d'additifs particuliers utilisant des charges, des pigments, des agents thixotropiques
B32B 37/04 - Procédés ou dispositifs pour la stratification, p. ex. par polymérisation ou par liaison à l'aide d'ultrasons caractérisés par la fusion partielle d'au moins une couche
Provided is a method for the separation of blood cells from a blood sample, which method comprises: (a) contacting the blood sample with an agent having a binding component that binds blood cells to form bound blood cells; and (b) separating the bound blood cells from the blood, wherein the agent is capable of binding a plurality of different blood cell types, and wherein the binding component is capable of binding to a protein expressed on a surface of the blood cells. Also provided is a method for the separation of red blood cells from a blood sample, which method comprises: (a) providing a sample collection vessel comprising an agent having a binding component that binds red blood cells; (b) collecting a blood sample in the sample collection vessel such that red blood cells bind to the agent; (c) removing the blood sample from the collection vessel such that red blood cells remain in the vessel; wherein the vessel or the agent comprises a means for retaining the red blood cells in the vessel on removal of the blood sample.
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
A microfluidic system comprising a 1st reaction zone, a 2nd reaction zone, a reagent delivery channel configured to deliver one or more reagents to the 1st reaction zone, a waste channel to remove waste from the 2nd reaction zone, a 1st sample delivery channel configured to deliver a sample to the 1st reaction zone and a 2nd sample delivery channel configured to deliver a sample to the 2nd reaction zone; wherein the microfluidic system comprises a means for retaining one or more reagents in each reaction zone; and wherein the 1st reaction zone and 2nd reaction zone are connected in series by a reaction zone channel.
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
The invention provides new culture media and methods for pluripotent stem cells, in particular human embryonic stem (hES) cells, which provide significant advantages over known culture media and methods. The culture media of the invention comprise, amongst other ingredients, a nuclear hormone receptor agonist, in particular a farnesoid X receptor (FXR) agonist, a retinoid X receptor (RXR) or retinoic acid receptor (RAR) agonist, a peroxisome proliferator-activated receptor (PPAR) agonist, and/or a thyroid hormone receptor (THR) agonist. The invention also provides related culture medium supplements, compositions and uses.
C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
Provided is a device for assaying one or more analytes, said device comprising an electrode, a means for optical detection; and a means for electrochemical detection, wherein the device is configured such that the electrode is capable of promoting transport of an analyte when a field is applied to the analyte via the electrode, and wherein the means for electrochemical detection employs the electrode and the means for optical detection employs the electrode, and wherein the device is configured to carry out dielectrophoresis. Further provided is the use of the device of the present invention for promoting transport of an analyte, detecting the optical properties of the analyte and detecting the electrochemical properties of the analyte. Also provided is method for assaying one or more analytes, which method comprises the steps of: promoting transport of an analyte, performing an optical measurement of the analyte and performing an electrochemical measurement of the analyte, which method employs the device of the present invention.
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
G01N 33/48 - Matériau biologique, p. ex. sang, urineHémocytomètres
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
C12Q 1/00 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
78.
A CLAMPING SYSTEM AND SELF ADVANCING SUPPORT PLATFORM
Clamp for clamping an article including a plurality of pads (10) which may be arranged in a circle around a support frame (90) and pivotally connected thereto by pivot arms (26) pivotable about an axis parallel to the axis of an article (92) to which the pads (10) are to be clamped. The pads (10) are supported on the arms (26) by ball-joints or universal joints (48) such as to ensure any off-center load L is passed through said pads (10) as a vertical load having no radial component.
B66C 1/42 - Organes de saisie engageant uniquement les faces externes ou internes des objets
B66C 1/62 - Éléments ou dispositifs de prise de la charge adjoints aux mécanismes de levage, de descente ou de halage, ou adaptés pour être utilisés avec ces mécanismes et transmettant les efforts à des articles ou à des groupes d'articles par moyens mécaniques comportant des organes de saisie ayant une forme complémentaire de celle des objets à manipuler
F03D 1/00 - Mécanismes moteurs à vent avec axe de rotation sensiblement parallèle au flux d'air pénétrant dans le rotor
The present invention provides an imaging method for obtaining an image of a patient by means of a contrast agent wherein the method comprises subjecting the patient to an imaging method for which the contrast agent is suitable, wherein the contrast agent comprises: (a) a binding moiety; and (b) a recognition moiety capable of targeting the contrast agent to a site within the body of the patient, and wherein the binding moiety comprises a metal-binding protein, polypeptide or peptide which is bound to or encapsulates a magnetic or magnetisable substance.
Provided is a vector for use in delivering a therapy to or removing a therapy from a site within a patient, wherein the vector comprises: a) a binding moiety; and b) a therapeutic agent, wherein the binding moiety comprises a metal-binding protein, polypeptide or peptide which is bound to or encapsulates a magnetic or magnetisable substance, and wherein the vector is to be administered using a device comprising an electromagnet and an element suitable for bringing the therapeutic agent into proximity with the site.
A61K 41/00 - Préparations médicinales obtenues par traitement de substances par énergie ondulatoire ou par rayonnement corpusculaire
A61K 47/48 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. supports, additifs inertes l'ingrédient non actif étant chimiquement lié à l'ingrédient actif, p.ex. conjugués polymère-médicament
A61K 49/08 - Préparations de contraste pour la résonance magnétique nucléaire [RMN]Préparations de contraste pour l'imagerie par résonance magnétique [IRM] caractérisées par le support
A61K 49/18 - Préparations de contraste pour la résonance magnétique nucléaire [RMN]Préparations de contraste pour l'imagerie par résonance magnétique [IRM] caractérisées par un aspect physique particulier, p. ex. émulsions, microcapsules, liposomes
Provided is a label for an analyte, which label is attached to a magnetic or magnetisable substance, the label comprising: (a) a recognition moiety for attaching the label to the analyte; and (b) a moiety for binding or encapsulating the magnetic or magnetisable substance; wherein the moiety for binding or encapsulating the magnetic or magnetisable substance comprises a metal-binding protein, polypeptide, or peptide.
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
82.
EFFICIENT INSERTION OF DNA INTO EMBRYONIC STEM CELLS
The present invention relates, in general, to a method for introducing a heterologous replacement gene sequence into a host embryonic stem cell to replace an endogenous host gene target sequence. In particular, the invention relates to a method for inserting large pieces of DNA into embryonic stem cells with improved efficiency, by first deleting the endogenous host gene target sequence, and subsequently utilising two proximally positioned site-specific recombinase target (RT) sites to insert a heterologous replacement gene sequence into the host chromosome.
Provided is a sample collection container comprising one or more reagent bodies, wherein each body comprises one or more reagents confined by a restraining agent, wherein the restraining agent is capable of being broken down to release the one or more reagents, and wherein the one or more reagents are dispersed through the restraining agent. Further provided is a cartridge system comprising: (a) a reagent component for storing one or more reagents; and (b) a processing component for processing the one or more reagents in an assay; wherein one or more of the components comprise one or more reagent bodies, wherein each body comprises one or more reagents confined by a restraining agent, wherein the restraining agent is capable of being broken down to release the one or more reagents, and wherein the one or more reagents are dispersed through the restraining agent; and further wherein the reagent component and the processing component are configured to be coupled together to form a cartridge, and wherein the reagent component and/or the processing component comprise at least one compartment configured to accept waste from the assay, the reagent component not taking part in processing the reagents in the assay, except to accept waste from the processing component.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
Provided is a method of attaching a substance to a surface, which method comprises contacting a surface comprising amine reactive groups with a substance labelled with a peptide tag such that the substance is covalently attached to the surface via the peptide tag, wherein the peptide tag comprises one or more histidine residues, one of which is a terminal histidine residue having a free N-terminal amino group. Also provided is a method of processing or analysis which comprises a method of attaching a substance to a surface as detailed above and comprises one or more further steps of processing or analysing the substance. The present invention farther provides a method of processing or analysis comprising the steps of: a) attaching a substance to a surface by a method as defined above b) contacting the surface with a sample comprising an analyte in order that the analyte in the sample binds to the substance attached to the surface; and c) processing and/or analysing the analyte
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
Provided is a method for processing a sample, which method comprises: a) contacting a binding phase, which binding phase is capable of binding an analyte, with the sample in the presence of a medium; b) applying across the medium a first alternating field composed of a plurality of pulses and having a first frequency, a first pulse duration and a first pulse rise time; c) optionally applying across the medium a second alternating field; and d) thereby influencing the sample and/or the binding phase in the medium.
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
G01N 33/48 - Matériau biologique, p. ex. sang, urineHémocytomètres
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
C12Q 1/00 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
The invention relates to a method for screening for the effects of non-genotoxic carcinogens in an animal model. The invention also relates to animal models that are suitable for use in such a method, and cell lines derived from these animals for in vitro screening purposes. More specifically, the invention relates to a transgenic rodent animal which has been humanised for the nuclear transcription factors CAR, PXR and PPARα, and in which the endogenous equivalent genes have been rendered inoperable.
An implementation tool for generating an implementation of a first data structure, wherein the first data structure comprises a plurality of linked structural components, and wherein the first data structure represents meaningful components of a given system and a parent set of interrelationships between those meaningful components, the tool comprising: first-data-structure input means, operable to receive a said first data structure, or a description thereof; and processing means operable to generate an implementation of the received first data structure, the implementation comprising: a second data structure, or a description thereof, corresponding to said first data structure, wherein said second data structure is defined by a subset of the parent set of interrelationships; and implementation rules which allow the parent set of interrelationships to be enforced during a subsequent processing operation which utilises said implementation.
The present invention provides a multi-layered corrugated cylindrical tubular structure formed from a strip (10) of material having one edge reduced in diameter by a step portion (16) and reduced in length by corrugations (18). Said strip maybe formed on a forming arrangement comprising confronting corrugating rollers (74, 76) having regions formed with corrugating undulations of differing height and an un-corrugated portion.
B21C 37/12 - Fabrication de tubes ou de tuyaux métalliques à jonction hélicoïdale
B21D 13/04 - Opérations permettant d'obtenir des tôles, barres ou profilés, à surface ondulée ou sinueuse par laminage
F16L 9/16 - Tuyaux rigides faits d'enroulements de feuilles ou de bandes, avec ou sans armature
F16L 11/16 - Manches, c.-à-d. tuyaux flexibles en un matériau rigide, p. ex. en métal ou en matériaux plastiques durs faites d'enroulements de bandes ou de lanières profilées
A method of assigning an identifier to a mention of an entity in a document carried out by computing apparatus including a display and one or more user operable input devices. A plurality of candidate identifiers are received from a term identification module in respect of a mention of an entity in a document, each candidate identifier being a reference to an entity in connection with which entity property data is stored in one or more entity databases. A list is displayed in a first region of the display, the list having a plurality of user-selectable entries, each entry in the list concerning the entity referred to by one of the said plurality of candidate identifiers, each entry comprising properties of the respective entity. At least one of the said properties is retrieved from the said one or more entity databases. In response to the selection by a user of an entry in the list, additional properties of the entity which the selected entry concerns are displayed in a second region of the display, the additional properties being retrieved at least in part from the one or more said databases. Responsive to an identifier assignment instruction received from a user in connection with a selected entity which a list entry concerns, an identifier of the selected entity is assigned as identifier of the mention of the entity. Filters are provided to enable a user to restrict the entities in connection with which a list entry is provided to those which fulfil user specified criteria. The properties which are displayed in the first and second region of the display are customisable for different domains and applications.
A brand protection feature/taggant reader and/or writer instrument comprising a secure processing environment and a non-secure processing environment, the instrument being operable to execute a process that is split between the secure and non-secure environments in accordance with pre-defined criteria.
G06F 21/14 - Protection des logiciels exécutables contre l’analyse de logiciel ou l'ingénierie inverse, p. ex. par masquage
G06F 21/53 - Contrôle des utilisateurs, des programmes ou des dispositifs de préservation de l’intégrité des plates-formes, p. ex. des processeurs, des micrologiciels ou des systèmes d’exploitation au stade de l’exécution du programme, p. ex. intégrité de la pile, débordement de tampon ou prévention d'effacement involontaire de données par exécution dans un environnement restreint, p. ex. "boîte à sable" ou machine virtuelle sécurisée
The present invention provides a strip (10) and a tubular article (74) formed form said strip (10) which may, for example, be used in the oil and gas industry for transporting fluids which may be volatile fluids or corrosive fluids and which may be at elevated temperatures and / or pressure. The strip (10) includes a plurality of combined step (joggle) and rib arrangements In the finished assembled article, the strip (10) is wound in helically self-overlapping relationship such as to allow corresponding step portions to sit one within the other. The step effectively provides the dual function of a joggle and a rib as known in the art and does so in a manner that reduces the forming stresses in the material and increases the strength of the final article.
This invention relates to a light guide device and methods of manufacture. The light guide device is suitable for use in a range of applications, particularly in connection with the backlighting of displays, for example, liquid crystal displays. The light guide device comprises a combination of guide layers and one or more scattering structures in order to mask the appearance of one or more light sources.
This invention relates to film layer which is suitable for use in a light guide plate and methods of forming said film layer and light guide plate. The invention also relates to the light guide plate and light guide devices made therefrom. The film and light guide plate are suitable for use in a range of applications, particularly in connection with the backlighting of displays, for example, liquid crystal displays.
Disclosed is a computer-implemented method of presenting data which has been automatically extracted from a digital representation of a document to a curator for review, the extracted data comprising annotation entity data concerning one or more instances of entities which have been identified in the digital representation of a document, the annotation entity data comprising data specifying the location of the identified instances of entities within the digital representation of a document, the method comprising the steps of (i) displaying in a first region of a display screen a user selectable portion of the digital representation of a document with said instances of entities which are specified by the annotation entity data as being located within the displayed portion of the digital representation of a document highlighted at the location specified by the annotation entity data; (ii) displaying in a second region of the display screen a list of a plurality of instances of entities which have been identified in the digital representation of a document, at least one of the listed instances of an entity having a user selectable user interface element associated therewith; and (iii) responsive to a user selecting the user selectable user interface element associated with an instance of an entity, adjusting the portion of the digital representation of a document which is displayed in the first region to include the location within the digital representation of a document where the instance of an entity associated with the selected user interface element is located.
The invention relates to the generation of mouse models of drug metabolism in which clusters of genes that are involved in drug metabolism have been knocked out. The development of new drugs and chemicals for therapeutic use or for other purposes is extremely complex. Of particular importance is the understanding of how these chemical agents are handled in the body, whether they have appropriate pharmacokinetics and whether, as a consequence of metabolism, any safety issues arise. Many of the proteins that are involved in the metabolism, disposition and elimination of drugs are members of multigene families that exhibit very marked species differences in gene number, function and regulation. For these reasons, experiments carried out in laboratory animals to establish routes of metabolism or toxicity can be severely compromised and, as a consequence, do not faithfully represent the human situation. One example of this complexity is reflected in the mammalian cytochrome P450 system, where the sizes of multigene families of proteins which carry out particular metabolic functions vary enormously between species.
C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales
A01K 67/027 - Nouvelles races ou races modifiées de vertébrés
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
Automatic information extraction apparatus for extracting data for review by a human curator from digital representations of documents comprising natural language text, the automatic information extraction apparatus having a plurality of selectable operating modes in which the automatic information extraction apparatus is operable to extract different data for review by a human curator. In the different operating modes, the information extraction apparatus may extract data with a different balance between recall and precision.
There is provided an antenna element for use in an ultra wideband network, the antenna element comprising a radiating element, for radiating signals over a range of frequencies in response to a signal received at a feed point; and a frequency shaping device located near the feed point of the radiating element for acting as a broad- banding device for the radiating element. A plurality of antenna elements may be formed into an antenna array.
H01Q 9/30 - Antennes résonnantes avec alimentation à l'extrémité d'un élément actif allongé, p. ex. unipôle
H01Q 15/00 - Dispositifs pour la réflexion, la réfraction, la diffraction ou la polarisation des ondes rayonnées par une antenne, p. ex. dispositifs quasi optiques
H01Q 19/32 - Combinaisons d'éléments actifs primaires d'antennes avec des dispositifs secondaires, p. ex. avec des dispositifs quasi optiques, pour donner à une antenne une caractéristique directionnelle désirée utilisant un dispositif secondaire constitué par plusieurs éléments conducteurs sensiblement rectilignes l'élément actif primaire étant alimenté par son extrémité et allongé
H01Q 21/20 - Réseaux d'unités d'antennes, de même polarisation, excitées individuellement et espacées entre elles les unités étant espacées le long d'un trajet curviligne ou adjacent à celui-ci
A decentralised, distributed approach to performing authorisation involves receiving an authorisation request at a service providing device, for example 'Carol', and then retrieving trust information from other peer devices in the network. The gathered information is used by the device 'Carol' to make a well-informed authorisation decision.
The application describes anti-tamper techniques for protecting a program code portion against tampering. According to the described techniques, a sequence of code segments having a root-code segment and a plurality of sub-code segments is defined. Each sub-code segment is provided with an integrity checking portion for checking the integrity of a target code segment. At runtime, the integrity checking portion of a given sub-code segment carries out a checking procedure on the respective target code segment to obtain a runtime result which is compared with a reference result to verify that the target portion of the program has not been tampered with.
G06F 21/54 - Contrôle des utilisateurs, des programmes ou des dispositifs de préservation de l’intégrité des plates-formes, p. ex. des processeurs, des micrologiciels ou des systèmes d’exploitation au stade de l’exécution du programme, p. ex. intégrité de la pile, débordement de tampon ou prévention d'effacement involontaire de données par ajout de routines ou d’objets de sécurité aux programmes
Authentication in an ad-hoc network is established between a first device (for example a service-requesting device) and a second device (for example a service-providing device) using a third device (a peer device). An authentication request is transmitted from the first device to the second device. The second device transmits a query message to at least one third device (i.e. peer device). If the peer device has previously been authenticated with the first device, the peer device sends an authentication credential, for example an authentication key, to the first and second devices. Upon receiving the authentication credential, the first device sends the authentication credential to the second device. The second device then compares the authentication credential received from the first device with the authentication credential received from the third device, and authenticates the first device with the second device if the authentication credentials match. Preferably the authentication credential from the third (peer) device to the first device is encrypted.
brevets
