Abrégé

The invention relates to an apparatus for the thermal treatment of samples contained in sample containers (9), said apparatus comprising: a sample block (4) with a receiving region for the sample containers (9); a first temperature-control device which is thermally coupled to the sample block (4) and is designed to set a temperature of the sample block (4); a cover plate (2) for sample containers (9) arranged in the receiving region of the sample block (4); a second temperature-control device which is thermally coupled to the cover plate (2) and is designed to set a temperature of the cover plate (2); and a control unit (13) which is connected to the first and the second temperature-control device and is designed to control the first and the second temperature-control device, the control unit (13) being designed to control the temperature of the sample block (4) and the temperature of the cover plate (2) by means of the first and the second temperature-control device so that said temperatures are coordinated with one another. The invention also relates to a method for the thermal treatment of samples contained in sample containers.

Classes IPC  ?

• B01L 7/00 - Appareils de chauffage ou de refroidissementDispositifs d'isolation thermique
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes

Abrégé

The present invention relates to an atomic absorption spectrometer (1) for analyzing a sample, comprising a radiation-sources unit (2) for generating a measuring beam (3), an atomization unit (4) for atomizing the sample such that the atomized sample is located in a beam path of the measuring beam (3), and a detecting unit (5) for detecting absorption of the measuring beam (3). The radiation-sources unit (2) comprises at least one light-emitting diode (9). According to the invention, the detection unit (5) comprises a polychromator arrangement, in particular a high-resolution polychromator arrangement, as a spectrometric arrangement (6).

Classes IPC  ?

• G01J 3/42 - Spectrométrie d'absorptionSpectrométrie à double faisceauSpectrométrie par scintillementSpectrométrie par réflexion
• G01N 21/31 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique
• G01J 3/10 - Aménagements de sources lumineuses spécialement adaptées à la spectrométrie ou à la colorimétrie
• G01J 3/02 - SpectrométrieSpectrophotométrieMonochromateursMesure de la couleur Parties constitutives
• G01J 3/18 - Production du spectreMonochromateurs en utilisant des éléments diffractants, p. ex. réseaux
• G01J 3/20 - Spectromètres à cercle de Rowland
• G01J 3/22 - Spectromètres à miroir de Littrow

Abrégé

The invention relates to a filtering method for isolating and/or quantifying, from a sample, at least one substance to be investigated, comprising: - introducing, via a sample inlet (3a), a first quantity of the sample into a filter module (2) which has a housing (3) with a first opening forming the sample inlet (3a) and a second opening which is covered by a filter (4) and forms a sample outlet (3b), wherein the filter (4) is designed to hold back a first portion of the sample and to allow a second portion of the sample to pass through; - conducting the sample from the sample inlet (3a) through the filter (4) and the sample outlet (3b) by applying a pressure difference between a side of the filter (4) facing the sample inlet (3a) and a side of the filter (4) facing away from the sample inlet (3a), wherein the second portion of the sample leaves the filter module (2) through the sample outlet (3b) as a filtrate; - while the sample is being conducted from the sample inlet (3A) through the filter (4) to the sample outlet (3b), detecting a series of temporally sequentially recorded measurement values of a measurement variable which represents the pressure difference and/or a volumetric flow through the filter (4); - comparing the measurement values to a predefined reference value of the measurement variable; and - ending the filtering method if successively detected measurement values of the measurement variable, over a predefined timespan, are equal to the reference value and/or lie within a predefined range of values around the reference value. The invention also relates to a device with which the method can be carried out.

Classes IPC  ?

• B01D 37/04 - Commande de la filtration
• G01N 1/40 - Concentration des échantillons

Abrégé

The present invention relates to an apparatus (1) for controlling the temperature of a sample carrier (2), and to an automatable laboratory workplace comprising an apparatus (1) according to the invention. The apparatus comprises a heating device (2) having a heater (3) and a movable heating cover (6), which is arranged over the receiving region of the heater (3) and is designed to press the sample carrier (4) in a heating position (H) into the receiving region (3a) of the heater (3) with a predefinable contact pressure, and a transport device (8), which is designed to introduce the sample carrier (3) into the apparatus (1) from an insertion position (E) outside the apparatus (1). According to the invention, the transport device (8) comprises a loading unit (9), which comprises a receiving unit (10) for receiving the sample carrier (4) and is movable between an insertion position (E) and an intermediate position (Z), in which the sample carrier (4) is situated inside the apparatus (1) and above the receiving region (3a) of the heater (3). The transport device (8) is arranged and/or designed in such a way that at least the sample carrier (4) is movable from the intermediate position (Z) into the heating position (H) by means of a movement of the heating cover (6). In addition, the transport device (8) comprises at least one return element (11), which is designed to move at least the sample carrier (4) from the heating position (H) back into the intermediate position (Z).

Classes IPC  ?

• B01L 7/00 - Appareils de chauffage ou de refroidissementDispositifs d'isolation thermique
• B01L 9/00 - Dispositifs de supportDispositifs de serrage
• G01N 35/02 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse

Abrégé

The present invention relates to a lid (3) for a microtiter plate (1) having a multiplicity of wells (2) which are arranged on an upper side (U) of the microtiter plate (1) and serve for the accommodation of samples, wherein the lid (3) is attachable, especially in a detachable manner, to the microtiter plate (1) such that it covers at least the upper side (U) of the microtiter plate (1), wherein the lid (3) comprises a main body (4) which is formed and/or constituted such that it is transparent at least to light of at least one specifiable wavelength at least in the regions situated above the wells (2) in the microtiter plate (1) when the lid (3) is applied to the microtiter plate (1), and wherein the lid (3) comprises at least one closing element (5) which is formed and/or arranged such that it closes at least one of the wells (2) in the microtiter plate (1) when the lid (3) is applied to the microtiter plate (1). The invention also relates to a system composed of a microtiter plate (1) having a lid (3) according to the invention and to an automatable laboratory workstation having a system according to the invention.

Classes IPC  ?

• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
• G01N 21/03 - Détails de structure des cuvettes
• G01N 21/25 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes

Abrégé

The present invention relates to a device (1) for isolating at least one substance from a specimen, comprising a filter module (2) with a specimen inlet (3a), a specimen outlet (3b) and a filter element (4) for isolating the substance, and relates to a pressure generating device (5), which is designed for generating a positive pressure, at least in the region of the specimen inlet (3a). According to the invention, the device (1) also comprises a suction extraction device (7), which is designed to generate a negative pressure, at least in the region of the specimen outlet (3b). Furthermore, the present invention relates to a method for isolating at least one substance from a specimen.

Classes IPC  ?

• C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
• G01N 1/40 - Concentration des échantillons

Abrégé

311335511111123232322331111112311). In addition, the present invention relates to a computer program which is configured to carry out a method according to the invention, and to a computer program product having a computer program according to the invention.

Classes IPC  ?

• H01J 49/40 - Spectromètres à temps de vol

Abrégé

13131313133) out of an ion beam (2).

Classes IPC  ?

• H01J 49/40 - Spectromètres à temps de vol

Abrégé

A spectrometer assembly (10) with a two-dimensional spectrum comprising a first dispersing element (31) for the spectral decomposition of radiation in a main dispersion direction, an imaging optical system (17) for imaging in an image plane the radiation penetrating through an inlet gap (15) in the spectrometer arrangement (10) and enabling a two-dimensional spectrum to be produced, and a surface detector (39) with a two-dimensional arrangement of a plurality of detector elements in the image plane. Said spectrometer assembly is characterized in that a reflector, a refractor, a lens array or another optical element is arranged in the beam path at a point where the dispersed, monochromatic bundles are present in a separated manner, and the reflector, the refractor, the lens array or the other optical element have a surface in the form of a free-form surface wherein the surface occupied by the selected images of the inlet gap at different wavelengths in the image plane is optimised over a selected spectral range of the two-dimensional spectrum.

Classes IPC  ?

• G01J 3/14 - Production du spectreMonochromateurs en utilisant des éléments réfringents, p. ex. prisme
• G01J 3/18 - Production du spectreMonochromateurs en utilisant des éléments diffractants, p. ex. réseaux
• G01J 3/02 - SpectrométrieSpectrophotométrieMonochromateursMesure de la couleur Parties constitutives
• G01J 3/28 - Étude du spectre

Abrégé

The invention relates to a temperature-control device having a reaction vessel (1), comprising a heat-insulated interior (2) covered by a cover (3), in which interior the reaction vessel (1) is accommodated. The reaction vessel (1) consists of a hollow body (1.1), closed with a base (1.2) on one side and a cap (1.3), wherein the base (1.2) is in contact with a heatable heating block (7) in order to heat a sample (8) which is located in the reaction vessel (1). The hollow body (1.1) is surrounded by a heatable heating body (4) which is in connection with the cover (3) via a heat-conducting contact region (5) so that the heating body (4) heats the hollow body (1.1) directly and heats the cap (1.3) indirectly via the cover (3).

Classes IPC  ?

• B01L 7/00 - Appareils de chauffage ou de refroidissementDispositifs d'isolation thermique

Abrégé

The invention relates to an analysis device for determining a measurement variable which is based on the concentration of one or more contents of a sample, comprising the following: - a digestion reactor with a gas inlet and a gas outlet; - a measuring device which is connected to the gas outlet of the digestion reactor; - a control and analysis device which is designed to receive and process measurement values that are registered by the measuring device and are based on the measurement variable; - an oxygen generating device; and - a gas line system which connects the oxygen generating device to the gas inlets of the digestion reactor in order to supply oxygen generated by the oxygen generating device to the digestion reactor, wherein the gas line system comprises a gas storage device which has at least one chamber with a variable volume for receiving an oxygen quantity to be stored.

Classes IPC  ?

• G01N 31/12 - Utilisation de la combustion

Abrégé

The invention relates to an analysis device for determining a measurement quantity that depends on the concentration of one or more, in particular oxidizable constituents of a sample, which device comprises: a breakdown reactor having an oxygen feed for introducing oxygen into the breakdown reactor and a gas outlet, which connects the breakdown reactor to a measuring apparatus; a heating device for heating the breakdown reactor to a specified operating temperature; an oxygen-producing apparatus comprising at least one oxygen-permeable membrane, in particular composed of a ceramic material; a housing, in which a insulating tube surrounding the breakdown reactor, the heating device, and the oxygen-producing apparatus is arranged; and a feed-gas conducting system for feeding a feed gas to the at least one membrane of the oxygen-producing apparatus, the feed-gas conducting system comprising a reaction chamber that surrounds the at least one membrane and being connected to at least one inflow channel open to the surroundings of the analysis device. The invention is characterized in that at least two, in particular tubular, intermediate walls, which are arranged coaxially with respect to the tube axis of the insulating tube and which surround the breakdown reactor, are arranged inside the insulating tube, which intermediate walls divide an intermediate space between the breakdown reactor and the insulating tube into the annular chambers forming the feed-gas conducting system, which annular chambers are connected to each other by means of overflow openings.

Classes IPC  ?

• G01N 31/12 - Utilisation de la combustion

Abrégé

The invention relates to a method for identifying a subset of polynucleotides from an initial set of polynucleotides corresponding to the human genome for the in vitro determination, in a sample, of the severity of the host response of a patient in an acute infectious and/or acute inflammatory state, wherein a measuring device is used, which has a plurality of different gene probes, which represent substantially the entire human genome, wherein the test subjects are classified into at least two of the clinically determined phenotype groups according to the infection status and/or inflammation status of the test subjects, the changes of the gene expression signals between the phenotype groups are statistically compared, and gene probes whose gene expression signals are changed between at least two phenotype groups in a statistically significant manner are selected. A master score is determined therefrom as a measure of the severity of the host response, and a number of polynucleotides considerably reduced compared to the initial set is identified by determining a score that does not exceed a specified deviation from the master score. Said score can be used to diagnose, predict the development of, or monitor an acute infectious and/or inflammatory state of a patient and/or to monitor the course of therapy and/or for focus monitoring.

Classes IPC  ?

• C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques

Abrégé

The aim of the invention is to provide a cuvette for small volumes avoiding the disadvantages of the prior art, particularly allowing measurements directly in a system simply by feeding further samples, and is achieved in that the cuvette for the optical analysis of small volumes comprises a structured layer (support substrate) having at least one channel, wherein at least the underside of the structured layer is closed by a thin, optically transparent layer and the channel has at least two fluid interfaces connected thereto to conduct fluids.

Classes IPC  ?

• G01N 21/03 - Détails de structure des cuvettes
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes

Abrégé

A method for producing an activated mercury collector is provided, comprising the following steps: a) Application of mercury onto a substrate surface that contains a precious metal, b) Heating of the surface to 300°C - 1000°C, c) Cooling of the surface to below 100°C, d) Repetition of steps a) to c), if necessary. In addition, an activated mercury collector obtainable according to this method, and a method for the selective determination of mercury species in a liquid medium, are provided.

Classes IPC  ?

• G01N 21/31 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique
• G01N 33/00 - Recherche ou analyse des matériaux par des méthodes spécifiques non couvertes par les groupes

Abrégé

The invention relates to an arrangement for multichannel fluorescence measurement in PCR samples. The problem addressed by the invention is to disclose an arrangement for multichannel fluorescence measurement in PCR samples which allows the measurement of the fluorescences in multiple color channels within a short time (e.g., about 4 seconds) in a plurality of samples (e.g., 96 samples), wherein it is to be ensured that the fluorescence dyes are excited close to the absorption maximum thereof. This problem is solved by the fact that the arrangement comprises a heating block (1) with a holder (2) for cavities (41) of a microtitration plate (4) which hold PCR samples, a transparent foil (9) for closing the cavities (41), and a measurement head (3) against which the heating block (1) is arranged and can be raised and lowered, wherein an excitation light unit (A), a detection unit (D), and a mechanical unit (M) are located in a measurement head (3), wherein the detection unit (D) contains a rotatable disk (20) with beam splitter modules (21; 31), a deviation mirror, and a detector (30), wherein the beam splitter modules (21; 31) comprise filters, a dichroic beam splitter, and a lens, such that the light from the excitation light unit (A), after it has passed through a first filter, can be coupled sequentially into a plurality of optical fibers (7) arranged on a circular track, over which the light can be coupled into the cavities (41) in an addressable manner via a two-dimensional lens array, (5) located on the underside of the measurement head (3), which has a heating device (8). Said mechanical unit is formed by a frame (16) with a mounting plate (19) and with a sliding carriage (12) that is driven by a motor (14) and movable in guides, with which the sample-side ends of the optical fibers (7) arranged in a row are movable in steps across the lens array (5), and wherein fluorescent light, emerging from the detector-side ends of the optical fibers (7), synchronously penetrates the dichroic beam splitter and a second filter and can be displayed on the detector by the mirror (30).

Classes IPC  ?

• G01N 21/64 - FluorescencePhosphorescence
• C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
• B01L 7/00 - Appareils de chauffage ou de refroidissementDispositifs d'isolation thermique