This disclosure provides systems and methods for the production of formulations of active pharmaceutical ingredients (APIs). In some embodiments, the disclosure provides an automated medicine formulation system comprising a portable and self-contained API formulating apparatus where the API and excipients are formulated to make a drug product meeting drug quality and safety specifications. The automated formulation system produces liquid formulations including, for example, injectable and intravenous medicines. The systems are capable of producing a plurality of individual sterile injectable doses of drug comprising a specific API and excipient(s), which can be formulated on demand in a GMP and FDA acceptable manner.
Described herein are methods for the preparation of imidazobenzodiazepines such as midazolam and its intermediates. The processes are capable of using continuous flow chemistry and systems.
Described herein are methods for the preparation of imidazobenzodiazepines such as midazolam and its intermediates. The processes are capable of using continuous flow chemistry and systems
This disclosure provides systems and methods for the on-demand synthesis, separation, purification and formulation of chemicals, and particularly for the on-demand production of pharmaceutical products. More particularly, the disclosure provides continuous-flow on-demand systems, comprising one or more reagent holding/dispensing containers, continuous-flow chemical synthesis modules and/or one or more separation, crystallization, filtration, wash and/or formulation modules, additionally comprising automated detection systems and methods for monitoring reagents, products and processing parameters and automated control systems and methods for controlling processing conditions and parameters.
A combination crystallizer washer filter dryer device and methods of using the device for producing washed and dried product of a reaction are disclosed. The device consolidates the functions of a crystallizer with the filtering, washing, and drying steps to a single vessel, eliminating the need for an additional crystallizer separate from the filter washer dryer device, the transfer of a reaction product or crystallized product from a crystallizer to a subsequent vessel for completing the filtering, washing, and drying process of the solid phase of the slurry.
B01J 19/18 - Réacteurs fixes avec éléments internes mobiles
B01D 29/05 - Filtres à éléments filtrants stationnaires pendant la filtration, p. ex. filtres à aspiration ou à pression, non couverts par les groupes Leurs éléments filtrants avec des éléments filtrants plats avec des supports
B01D 39/20 - Autres substances filtrantes autoportantes en substance inorganique, p. ex. papier d'amiante ou substance filtrante métallique faite de fils métalliques non-tissés
B01F 27/90 - Mélangeurs à agitateurs tournant dans des récipients fixesPétrins avec des agitateurs tournant autour d'un axe sensiblement vertical avec des palettes ou des bras
B01F 35/221 - Commande ou régulation des paramètres de fonctionnement, p. ex. du niveau de matière dans le mélangeur, de la température ou de la pression
A combination crystallizer washer filter dryer device and methods of using the device for producing washed and dried product of a reaction are disclosed. The device consolidates the functions of a crystallizer with the filtering, washing, and drying steps to a single vessel, eliminating the need for an additional crystallizer separate from the filter washer dryer device, the transfer of a reaction product or crystallized product from a crystallizer to a subsequent vessel for completing the filtering, washing, and drying process of the solid phase of the slurry.
B01F 35/00 - Accessoires pour mélangeursOpérations auxiliaires ou dispositifs auxiliairesParties ou détails d'application générale
B01D 29/78 - Manipulation du gâteau de filtration dans le filtre pour des raisons autres que la régénération pour le lavage
B01D 29/80 - Manipulation du gâteau de filtration dans le filtre pour des raisons autres que la régénération pour le séchage
B01F 27/231 - Mélangeurs à agitateurs tournant dans des récipients fixesPétrins caractérisés par l'orientation ou la disposition de l'axe du rotor avec une orientation variable pendant l'opération de mélange, p. ex. avec un axe de rotation inclinable
B01F 27/90 - Mélangeurs à agitateurs tournant dans des récipients fixesPétrins avec des agitateurs tournant autour d'un axe sensiblement vertical avec des palettes ou des bras
This disclosure provides systems and methods for the on-demand synthesis, separation, purification and formulation of chemicals, and particularly for the on-demand production of pharmaceutical products. More particularly, the disclosure provides continuous-flow on-demand systems, comprising one or more reagent holding/dispensing containers, continuous-flow chemical synthesis modules and/or one or more separation, crystallization, filtration, wash and/or formulation modules, additionally comprising automated detection systems and methods for monitoring reagents, products and processing parameters and automated control systems and methods for controlling processing conditions and parameters.
B01J 19/24 - Réacteurs fixes sans élément interne mobile
B01J 19/32 - Éléments de remplissage en forme de grille ou d'éléments composés de plusieurs pièces pour constituer une unité ou un module dans l'appareil de transfert de chaleur ou de matière
B01J 14/00 - Procédés chimiques généraux faisant réagir des liquides avec des liquidesAppareillage spécialement adapté à cet effet
Reactor systems, reactors, and removable liners for chemical and biological processes and manufacturing modules and systems using the same, are disclosed. Kits and methods of using the reactor systems and kits as with removable elements are also disclosed.
B01J 19/18 - Réacteurs fixes avec éléments internes mobiles
B01J 19/00 - Procédés chimiques, physiques ou physico-chimiques en généralAppareils appropriés
B01J 19/02 - Appareils caractérisés par le fait qu'ils sont construits avec des matériaux choisis pour leurs propriétés de résistance aux agents chimiques
This disclosure provides systems and methods for the production of formulations of active pharmaceutical ingredients (APIs). In some embodiments, the disclosure provides an automated medicine formulation system comprising a portable and self-contained API formulating apparatus where the API and excipients are formulated to make a drug product meeting drug quality and safety specifications. The automated formulation system produces liquid formulations including, for example, injectable and intravenous medicines. The systems are capable of producing a plurality of individual sterile injectable doses of drug comprising a specific API and excipient(s), which can be formulated on demand in a GMP and FDA acceptable manner.
A61J 1/20 - Dispositions pour le transfert des liquides, p. ex. du flacon à la seringue
B01F 25/432 - Tubes de mélange, p. ex. dans lesquels la matière est déplacée dans une direction radiale ou partiellement inversée avec des moyens pour diviser l’écoulement de matière en écoulements secondaires séparés et pour repositionner et recombiner ces écoulements secondairesMélange croisé, p. ex. en amenant la couche extérieure de la matière plus près de l'axe du tube ou vice-versa
B01F 25/60 - Mélangeurs à pompe, c.-à-d. mélange à l'intérieur d'une pompe
B01F 101/22 - Mélange d'ingrédients pour compositions pharmaceutiques ou médicales
This disclosure provides systems and methods for the production of formulations of active pharmaceutical ingredients (APIs). In some embodiments, the disclosure provides an automated medicine formulation system comprising a portable and self-contained API formulating apparatus where the API and excipients are formulated to make a drug product meeting drug quality and safety specifications. The automated formulation system produces liquid formulations including, for example, injectable and intravenous medicines. The systems are capable of producing a plurality of individual sterile injectable doses of drug comprising a specific API and excipient(s), which can be formulated on demand in a GMP and FDA acceptable manner.
Modular reactors comprising a chassis, reactor tubing and optionally a cover are disclosed. The chassis comprises a plurality of channels of different lengths into which a length of reactor tubing is placed to create the reactor portion of the flow reactor.
Disclosed herein are novel approaches for the on-demand continuous flow synthesis of cisatracurium. The synthesis route involves one or more steps wherein reactants are flown through a reactor. The resulting product is transferred to a filter directly in a continuous system.
C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 217/20 - Radicaux aralkyle avec des atomes d'oxygène liés directement au noyau aromatique dudit radical aralkyle, p. ex. papavérine
13.
REACTOR FILTER WASHER DRIER (R-FWD) APPARATUS AND METHODS OF USE THEREOF
A reactor filter washer dryer (R-FWD) apparatus and methods of using the apparatus for producing washed and dried product of a reaction is disclosed. The R-FWD comprises a vessel defining a process chamber, a filter plate laterally disposed on the vessel base, an agitator assembly, a solids discharge port in the vessel operable to remove the solid fraction of the slurry retained by the filter plate, and a filtrate outlet in the vessel for outflowing the liquid phase of the slurry filtered through the filter plate.
B01J 19/18 - Réacteurs fixes avec éléments internes mobiles
B01D 29/05 - Filtres à éléments filtrants stationnaires pendant la filtration, p. ex. filtres à aspiration ou à pression, non couverts par les groupes Leurs éléments filtrants avec des éléments filtrants plats avec des supports
B01D 39/20 - Autres substances filtrantes autoportantes en substance inorganique, p. ex. papier d'amiante ou substance filtrante métallique faite de fils métalliques non-tissés
B01F 27/90 - Mélangeurs à agitateurs tournant dans des récipients fixesPétrins avec des agitateurs tournant autour d'un axe sensiblement vertical avec des palettes ou des bras
B01F 35/221 - Commande ou régulation des paramètres de fonctionnement, p. ex. du niveau de matière dans le mélangeur, de la température ou de la pression
B01J 19/00 - Procédés chimiques, physiques ou physico-chimiques en généralAppareils appropriés
Modular reactors comprising a chassis, reactor tubing and optionally a cover are disclosed. The chassis comprises a plurality of channels of different lengths into which a length of reactor tubing is placed to create the reactor portion of the flow reactor.
Modular reactors comprising a chassis, reactor tubing and optionally a cover are disclosed. The chassis comprises a plurality of channels of different lengths into which a length of reactor tubing is placed to create the reactor portion of the flow reactor.
09 - Appareils et instruments scientifiques et électriques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Downloadable and recorded computer software and computer hardware for use in the manufacturing of pharmaceuticals Software as a Service (SAAS) services featuring computer software for use in the manufacture of pharmaceuticals; Platform as a service (PAAS) services featuring computer software for use in the manufacture of pharmaceuticals
