Systems and methods for determining a concentration of an analyte in a physiological fluid with a biosensor are presented. Current values are measured during application of voltage pulses across electrodes of the biosensor. Different intermediate analyte concentrations are calculated using different subsets of the measured current values and different scaling factors. A first intermediate analyte concentration has a first level of accuracy across a range of analyte concentrations. A second intermediate analyte concentration hasa higher level of accuracy in the low range. A third intermediate analyte concentration has a higher level of accuracy in the high range. The concentration of the analyteis determined as a function of the different intermediate analyte concentrations. The second intermediate analyte concentration, the third intermediate analyte concentration or an average,is selected if the first intermediate analyte concentration is in the low range,the high range or in between, respectively.
Systems and methods for determining a concentration of an analyte in a physiological fluid with a biosensor are presented. Current values are measured during application of voltage pulses across electrodes of the biosensor. Different intermediate analyte concentrations are calculated using different subsets of the measured current values and different scaling factors. A first intermediate analyte concentration has a first level of accuracy across a range of analyte concentrations. A second intermediate analyte concentration hasa higher level of accuracy in the low range. A third intermediate analyte concentration has a higher level of accuracy in the high range. The concentration of the analyteis determined as a function of the different intermediate analyte concentrations. The second intermediate analyte concentration, the third intermediate analyte concentration or an average,is selected ifthe first intermediate analyte concentration isin the low range,the high range or in between, respectively.
A hand-held test meter for use with an analytical test strip (such as an electrochemical-based analytical test strip) for the determination of an analyte (e.g., glucose) in a bodily fluid sample, the hand-held test meter including a housing with an analytical test strip contact pressure feature, a printed circuit board (PCB) with at least one solder bump disposed in the housing. The housing of the hand-held test meter is configured for the insertion of an analytical test strip therein. In addition, the analytical test strip contact pressure feature is configured to operatively apply pressure on the inserted analytical test strip such that at least one electrical contact of the inserted analytical test strip is operably pressed against the solder bump, thereby creating a direct operable electrical connection between the inserted analytical test strip and the solder bump of the PCB.
A hand-held test meter for use with an electro-chemical-based analytical test strip in the determination of an analyte in a bodily fluid sample includes a housing; a strip port connector disposed at least partially within the housing and configured to receive an electro-chemical based analytical test strip; a micro-controller disposed in the housing and configured to generate a micro-controller command signal; an electrode bias drive circuit block disposed in the housing and configured to generate a bias drive signal based on the micro-controller command signal, and a dynamic bias drive adjustment circuit block disposed in the housing and configured to receive at least one sensed electrode voltage and to adjust a bias drive signal from the electrode bias drive circuit block based on the sensed electrode voltage to create an adjusted bias drive signal.
A hand-held test meter for use with an electro-chemical-based analytical test strip in the determination of an analyte in a bodily fluid sample includes a housing; a strip port connector disposed at least partially within the housing and configured to receive an electro-chemical based analytical test strip; a micro-controller disposed in the housing and configured to generate a micro-controller command signal; an electrode bias drive circuit block disposed in the housing and configured to generate a bias drive signal based on the micro-controller command signal, and a dynamic bias drive adjustment circuit block disposed in the housing and configured to receive at least one sensed electrode voltage and to adjust a bias drive signal from the electrode bias drive circuit block based on the sensed electrode voltage to create an adjusted bias drive signal.
A system and a method for correcting an analyte concentration measurement taken by a test strip is described herein. The test strip includes at least two spaced apart electrodes defining an electrochemical cell or reaction chamber. An initial polarization parameter of the test strip is determined at the time of test strip manufacture and a testing polarization parameter is determined at the time of testing. A resulting correction factor is then determined based on the initial and testing polarization parameters. The correction parameter can be applied to a measured analyte concentration in order to correct the measured analyte concentration.
A mechanically operated medical infusion device with a dose counter (100) is disclosed herein. The infusion device includes a pump and at least one mechanical activation mechanism for mechanically engaging the pump to deliver a dose of medicament to cause a dose event. The dose counter includes a sensor for detecting a vibration signature indicative of the dose event and a micro-controller for recording the dose event.
A medical device with a self-sustaining power source is disclosed herein. The medical device includes e.g. a medical skin-patch type infusion pump having at least one mechanical and manual activation mechanism, e.g. comprising buttons (16, 18), for engaging the pump to cause a dose event. An energy generator, e.g. energy harvesting system based on a piezo crystal (402) mechanically coupled to a fixed portion (24) of the medical pump, coupled to the activation mechanism generates energy each time the activation mechanism is actuated. The generated energy is supplied to a dose counter of the infusion device.
A hand-held test meter ("HHTM") for use with analytical test strip in the determination of an analyte in a bodily fluid sample includes a housing, a strip port connector disposed at least partially within the housing, a micro-controller disposed in the housing, a voltage supply disposed in the housing, a fluid ingress detection circuit block ("FRIDCB") disposed in the housing and includes a paired signal and ground trace, and a ground-reference. A portion of the signal trace and ground trace are separated by a predetermined distance. The signal trace is electrically connected to the voltage supply and to the micro-controller and the ground trace is electrically connected to the ground-reference. With no ingress fluid, the signal trace is electrically isolated from the ground trace. The FRIDCB generates an output signal to the micro-controller that is dependent on fluid ingress into the meter housing, thus providing for detection of fluid ingress.
Various embodiments for a method that allow for a more accurate analyte concentration with a biosensor by determining at least one physical characteristic of the sample and determining whether a counter or reference electrode is causing an error by monitoring the working electrodes and flagging an error if the signal outputs of the working electrodes do not meet certain thresholds.
An analyte measurement system and method for determining a test strip current through an analyte of a physiological fluid sample on a test strip. The system includes a variable reference direct current voltage source and a fixed reference direct current voltage source forming a voltage bias across the electrodes of the test strip. The system also can include an integrator circuit comprising a capacitor and an operational amplifier. In one embodiment, a bias current circuit including a bias current resistor network, and provides a bias current. In another embodiment, the system can include an integrator circuit transistor switch configured to reset the integrator circuit.
A hand-held test meter for use with an electrochemical-based analytical test strip in the determination of an analyte (such as glucose) in a bodily fluid sample (for example, a whole blood sample) includes a housing, a micro-controller disposed in the housing, a test strip electrode to ground-reference switch circuit block disposed in the housing, a strip port connector configured for operational insertion of an electrochemical-based analytical test strip with an electrode (e.g., a reference electrode), and a ground-reference. In addition, the test strip electrode to ground-reference switch circuit block is configured to be in electrical communication with an electrode of an electrochemical-based analytical test strip inserted in the strip port connector. Moreover, the test strip electrode to ground-reference switch circuit block is configured to connect and disconnect the electrode of the inserted electrochemical-based analytical test strip to the ground-reference under operational control of the micro-controller.
The test meter includes a strip port connector configured and sized to receive a test strip and including a plurality of spaced electrical contacts disposed in an array upon a printed circuit board (PCB). Upon insertion of a test strip in the strip port connector, at least some of the plurality of spaced electrical contacts of the strip port connector are caused to engage each of the electrical contacts of the inserted test strip and in which a plurality of disparate test strip designs can be used in connection with the test meter and in which the array of electrical contacts of the strip port connector are disposed in parallel relation to the substantially planar surface of the inserted test strip and are brought into contact therewith for identifying the test strip and subsequent testing.
G01N 33/487 - Analyse physique de matériau biologique de matériau biologique liquide
H01R 12/71 - Dispositifs de couplage pour circuits imprimés rigides ou structures similaires
H01R 13/66 - Association structurelle avec des composants électriques incorporés
A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
14.
ACCURATE ANALYTE MEASUREMENTS FOR ELECTROCHEMICAL TEST STRIP TO DETERMINE ANALYTE MEASUREMENT TIME BASED ON MEASURED TEMPERATURE, PHYSICAL CHARACTERISTIC AND ESTIMATED ANALYTE VALUE AND THEIR TEMPERATURE COMPENSATED VALUES
Various embodiments for a method that allow for a more accurate analyte concentration with a biosensor by determining at least one physical characteristic signal representative of the sample containing the analyte and selecting an analyte measurement sampling time based on measured temperature, physical characteristic and estimated analyte values along with temperature compensations provided for specific parameters used in the test assay.
ACCURATE ANALYTE MEASUREMENTS FOR ELECTROCHEMICAL TEST STRIP TO DETERMINE ANALYTE MEASUREMENT TIME BASED ON MEASURED TEMPERATURE, PHYSICAL CHARACTERISTIC AND ESTIMATED ANALYTE VALUE
Various embodiments for a method that allow for a more accurate analyte concentration with a biosensor by determining at least one physical characteristic signal representative of the sample containing the analyte and selecting an analyte measurement sampling time based on measured temperature, physical characteristic and estimated analyte values.
A hand-held test meter includes an electrically and thermally insulating case ("ETIC") with an outwardly facing surface, a test meter electrical component ("TMEC") with a thermal contact portion disposed within the electrically-insulating case, and at least one thermal channel. The thermal channel includes a proximal contact portion with a proximal contact surface, a distal contact portion with a distal surface, and a channel portion connecting the proximal contact portion and the distal contact portion. The thermal channel is integrated with the ETIC such that the thermal channel extends through the ETIC from the outwardly facing surface and to the thermal contact portion of the TMEC. The extension is such that the proximal contact surface of the thermal channel is outside of the ETIC and the distal surface of the thermal channel is in contact with the thermal contact portion of the TMEC. The thermal channel is thermally conductive and electrically-insulating.
An electrochemical-based analytical test strip for the determination of an analyte (such as glucose) in a bodily fluid sample includes an electrically insulating base layer, an electrically conductive layer disposed on the electrically insulating base layer and including at least one electrode, an enzymatic reagent layer disposed on the at least one electrode, a patterned spacer layer, and a top layer. Moreover, the enzymatic reagent layer includes at least one naphthoquinone-based mediator and FAD-GDH enzyme. The naphthoquinone-based mediator can, for example, be at least one of, 2-naphthalenedione-4-(3-mercapto-1-propane sulfonic acid) and, 2-naphthalenedione-4-(3-mercaptopropionic acid).
C12Q 1/00 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions
18.
END-FILL ELECTROCHEMICAL-BASED ANALYTICAL TEST STRIP WITH PERPENDICULAR INTERSECTING SAMPLE-RECEIVING CHAMBERS
An electrochemical-based analytical test strip for the determination of an analyte (such as glucose) in a bodily fluid sample (for example, a whole blood sample) and/or a characteristic of the bodily fluid sample (e.g., hematocrit) includes a sample-entry chamber with a sample-application opening disposed on an end edge of the electrochemical-based analytical test strip, and first and second sample-determination chambers, each in direct fluidic communication with the sample-entry chamber. The electrochemical-based analytical test strip also includes first and second electrodes (such as first and second hematocrit electrodes) disposed in the first sample-determination chamber, and a third and fourth electrodes (for example working and reference electrodes) disposed in the second sample-determination chamber. Moreover, the first and second sample-determination chambers intersect the sample-entry chamber perpendicular (or nearly perpendicular) to one another and the first sample-determination chamber also intersects the sample-entry chamber in an aligned manner. The test strip can also include a shield electrode disposed in the sample-entry chamber, wherein the shield electrode is in electrical communication with one of the at least third electrode and fourth electrode.
An analytical test strip for the determination of an analyte (such as glucose) in, or a characteristic of, a bodily fluid sample includes an electrically-insulating base layer, a first patterned spacer layer disposed on the electrically-insulating base layer, a second patterned spacer layer disposed on the first patterned spacer layer; and a top hydrophilic layer disposed on the second patterned spacer layer. In addition, the electrically-insulating base layer, the first and second patterned spacer layers and the top hydrophilic layer define a tiered capillary chamber(s) that has a first tiered capillary chamber portion defined in the first patterned spacer layer and a second tiered capillary chamber portion defined in the second patterned spacer layer. Moreover, the first tiered capillary chamber portion and the second tiered capillary chamber portion are in direct fluidic communication with one another.
A hand-held test meter for use with an analytical test strip in the determination of an analyte in a bodily fluid sample includes a housing, a clock module disposed in the housing, a micro-controller disposed in the housing, a low-distortion signal generation circuit block ("LDSGCB") disposed in the housing, and a strip port connector configured to operationally receive the analytical test strip. The LDSGCB includes a signal summation circuit ("SSC") sub-block, a resistance-capacitance (RC) filter, and a single operational amplifier. The clock module and micro-controller are configured to generate phase-shifted square wave signals and output the phase-shifted square wave signals to the SSC. The SSC is configured to sum the phase-shifted square wave signals to generate a resultant summed-wave signal and output the resultant summed-wave signal to the RC filter. The RC filter is configured to filter harmonics from the resultant summed-wave signal thereby creating a reduced harmonic distortion signal.
A hand-held test meter (100) for use with an analytical test strip (TS, for example, an electrochemical-based analytical test strip) in the determination of an analyte (such as glucose) in a bodily fluid sample (e.g., a whole blood sample) includes a housing (110), a micro-controller (112) disposed in the housing (110), a body portion proximity sensor module (107) disposed at least partially in the housing (110), and a strip port connector (106) configured to operationally receive an analytical test strip (TS). The body portion proximity sensor module (107) of the analytical test strip is configured to sense presence of a user's body portion (e.g., a user's finger, forearm or palm) within a predetermined distance of the strip port connector (106) and, upon sensing the presence of such a body portion, transmit a signal to the micro-controller (110) indicating the presence of such a body portion. Such signal is used to switch the test meter (100) from a low-power standby mode to a high-power active mode.
An analyte meter (10) having a test strip port (22) is configured to detect an inserted test strip (24) using an unpowered grounded operational amplifier (80) while the analyte meter (10) is in sleep mode. After a test strip (24) is inserted and the meter (10) is activated, the operational amplifier (80) is powered and provides the sample current for measuring an analyte concentration in the sample.
A hand-held test meter for use with an electrochemical-based analytical test strip in the determination of an analyte in a bodily fluid sample includes a housing (110), a micro-controller (112) disposed in the housing, an operating range test strip simulation circuit block ("ORTSSCB" 114) disposed in the housing and a strip port connector ("SPC" 106) configured to operationally receive an electrochemical-based analytical test strip. The ORTSSCB is in electrical communication with the SPC. In addition, the ORTSSCB is configured to simulate an electrochemical-based analytical test strip inserted into the SPC and an operating range of bodily fluid samples applied to such an electrochemical-based analytical test strip by sequentially presenting a plurality of electrical loads. Each of the plurality of electrical loads is configured as a first resistor in series with a parallel configuration of a second resistor and a first capacitor. Moreover, the SPC is configured in electrical communication with the micro-controller.
An analyte meter (10) having nonvolatile memory is configured to update its firmware via a USB cable using the power provided by the cable to transfer program code into temporary storage (104) in the meter and to transfer the program code from the temporary storage (104) to a program memory (123) for reprogramming the meter's micro controller (120).
G06F 19/00 - Équipement ou méthodes de traitement de données ou de calcul numérique, spécialement adaptés à des applications spécifiques (spécialement adaptés à des fonctions spécifiques G06F 17/00;systèmes ou méthodes de traitement de données spécialement adaptés à des fins administratives, commerciales, financières, de gestion, de surveillance ou de prévision G06Q;informatique médicale G16H)
25.
HAND-HELD TEST METER MULTI-EVENT CONTROL SOLUTION MEASUREMENT REMINDER
A hand-held test meter for the determination of an analyte (such as glucose) in a bodily fluid sample (for example, a whole blood sample), includes a microprocessor block, a display module, and a memory block storing multi-event control solution measurement reminder instructions and operatively coupled to the microprocessor block. Moreover, the memory block, microprocessor block and display module are configured such that the multi-event control solution measurement reminder instructions, when executed by the microprocessor block, retrieve predetermined hand-held test meter multi-event data and determine if at least one of the hand-held test meter multi-event data meets an associated predetermined condition, and if at least one of the associated predetermined conditions are met, prompt a user via the display module using, for example, a pop-up display message, to perform a control solution measurement using the hand- held test meter.
A test strip for use with an analyte meter comprises an integrated power source, such as a battery wherein the test strip is configured upon insertion into the meter to provide sufficient power for completing a sample assay without requiring a separate power source in the meter.
Various embodiments for a method that allow for a more accurate analyte concentration with a biosensor by determining at least one physical characteristic of the sample and determining whether at least one output transient signal of the biosensor is erroneous by monitoring the biosensor and flagging an error if the signal outputs of the biosensor do not meet certain criteria.
A hand-held test meter includes a strip port connector to receive a test strip. A signal-measurement circuit applies a periodic voltage signal across a sample applied to the strip and detects a resulting current signal. The circuit provides data of the current signal at a digitizing frequency and a selected phase with respect to the voltage signal. A processor records one or more value(s) of the data and then alters the selected phase. Value(s) are thus recorded at each of a plurality of phases. The processor determines a phase difference of the current signal with respect to the voltage signal using the respective sets of value(s). A method for employing a test meter and a test strip is also disclosed, and includes measuring a respective plurality of points for each of a plurality of different measurement phases and determining a phase difference of a fluid sample therefrom.
Glucose measurement system comprising a test strip (100) and a test meter (200), the meter including a microcontroller (300) configured to apply a test voltage and measure a response current and further to determine an output differential (818) as the diffence in respective magnitudes of currents at successive time instants within a predetermined time window, and if the output differential is greater than zero (i.e. current is increasing) (820), to increment by one a first index and set a second index value as equal to the sum of the previous value of the second index and the output differential (822), and to flag an error (826) if both indexes become greater than a respective threshold (824) within the time window, otherwise, if the time instance is outside the time window (808), calculate the glucose concentration from the output signal (810). Corresponding method of calculating a glucose concentration.
Various embodiments of a technique to sample output signals at different time intervals from each of the electrodes in a biosensor to obtain respective glucose estimates including one where the output signals of at least one combination of electrodes measured at various time intervals are summed together to provide for a combined glucose estimate.
The invention shall allow a more accurate electrochemical test strip measurement by identifying erroneous output signals during a glucose measurement, thereby ensuring a much more accurate glucose test system and method. A glucose measurement system comprises a biosensor (62) having electrodes and a meter (10,100). The meter includes a microcontroller (38) configured to drive a signal to the electrodes, measure an output signal during the electrochemical reaction over a series of time intervals, determine an output differential (Delta I) as a difference of the output signal for consecutive time intervals and, if this output differential (Delta I) is greater than a threshold, increment an index value (x) by this output differential (Delta I). When the final index value (x) is greater than or equal to a predetermined index value, then an error is annunciated; otherwise the glucose value is annunciated.
A watertight casing for an electronic device includes an electrically-insulating plastic case (EIPC) and at least one electrically-conductive thermoplastic elastomer (ECTPE) contact. The EIPC includes inwardly and outwardly facing surfaces. The ECTPE contact that includes a proximal contact portion with a proximal contact surface, a distal contact portion with a distal contact surface, and a channel portion connecting the proximal contact portion and the distal contact portion. The ECTPE contact(s) is integrated with the EIPC such that the ECTPE contact(s) extends through the EIPC from the outwardly facing surface to the inwardly facing surface and such that the proximal contact surface is disposed in proximity to the inwardly facing surface and the distal contact surface is disposed in proximity to the outwardly facing surface. The ECTPE contact(s) is adhered to the EIPC such that a watertight seal between the outwardly facing surface and the inwardly facing surface is present therebetween.
A modular analytical test strip meter (100) includes a meter housing or body (108) and a plug-in analytical module (104) that is electrically and mechanically attached in a releasable fashion to the meter housing (108). When attached, the plug-in analytical module (104) includes resident circuitry configured to measure for an analyte of interest from an analytical test strip (14), the module (104) further including stored coded information such as firmware updates that can be utilized by the existing test meter (100) without requiring replacement of an entire system. The plug-in analytical module (104) and meter housing (108) includes as well complementary mating features (116, 120, 124, 128) and identification information is exhanged between the analytical module (104) and the meter housing (108).
An electronic device battery holder ("EDBH") for holding a battery with a positive pole and a negative pole includes at least one deflectable electrically-conductive positive terminal prong with a proximal end configured for fixed electrical connection to a power circuit of an electronic device, a deflectable distal end configured to contact a positive pole of a battery operably inserted into the EDBH, and a deflectable middle portion connecting the proximal end and the distal end. The EDBH also includes at least one compressible electrically-conductive negative terminal prong configured to exert a force on the operably inserted battery, to contact a negative pole of the battery, and for fixed electrical connection to the power circuit of the electronic device. The at least one deflectable electrically-conductive positive terminal prong is configured to deflect during insertion of a battery therein and to exert a compressive securing force on an operably inserted battery.
A physiological measurement system includes a biosensor providing a signal for a fluid sample. A processor determines a physiological parameter in the form of an analyte concentration using the biosensor signal. A network interface conveys data between the processor and a social network. The processor can transmit a query for analyte-data-request records to the social network, receive an indication of an analyte-data-request record from the social network, and transmit the determined data to the social network in response to the indication. The processor can alternatively retrieve user credentials from a storage device, transmit the credentials and the analyte data to the social network, retrieve different-user response data corresponding to the transmission, and present an indication of the response data. Methods for processing analyte or physiologic data are described. Various methods include transmitting credentials and stored analyte or physiologic data to the social network.
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
G16H 20/17 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p. ex. pour s’assurer de l’administration correcte aux patients administrés par perfusion ou injection
G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
A61B 5/1473 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang en utilisant des procédés chimiques ou électrochimiques, p. ex. par des moyens polarographiques invasifs, p. ex. introduits dans le corps par un cathéter
H04L 12/16 - Dispositions pour la fourniture de services particuliers aux abonnés
36.
PHYSIOLOGICAL MONITORING SYSTEM COMMUNICATING WITH AT LEAST ONE SOCIAL NETWORK
A physiological measurement system includes a biosensor providing a signal for a fluid sample. A processor determines a physiological parameter in the form of an analyte concentration using the signal from the biosensor. A network interface conveys data between the processor and a social network. The processor can transmit a query for analyte- data-request records to the social network, receive an indication of an analyte-data-request record from the social network, and transmit the determined analyte data or physiologic data to the social network in response to the indication. The processor can alternatively retrieve user credentials from a storage device, transmit the credentials and the analyte data to the social network, retrieve from the social network different-user response data corresponding to the transmission, and present an indication of the response data. Methods for processing analyte or physiologic data are also described. Various methods include transmitting credentials and the stored analyte or physiologic data to the social network.
G06F 19/00 - Équipement ou méthodes de traitement de données ou de calcul numérique, spécialement adaptés à des applications spécifiques (spécialement adaptés à des fonctions spécifiques G06F 17/00;systèmes ou méthodes de traitement de données spécialement adaptés à des fins administratives, commerciales, financières, de gestion, de surveillance ou de prévision G06Q;informatique médicale G16H)
37.
TEMPERATURE COMPENSATION FOR AN ANALYTE MEASUREMENT DETERMINED FROM A SPECIFIED SAMPLING TIME DERIVED FROM A SENSED PHYSICAL CHARACTERISTIC OF THE SAMPLE CONTAINING THE ANALYTE
Various embodiments for methods, systems, and meters that allow for a more accurate analyte concentration with a biosensor by determining at least one physical characteristic, particularly hematocrit, of the blood sample containing the analyte, particularly glucose, and deriving a specific sampling time based on a relationship between the physical characteristic, the estimated analyte concentration and sampling time. Additionally to that compensation of the measured glucose concentration for the effects of ambient temperature with a defined relationship between temperature in the environment, the meter or the biosensor is performed.
TRANSIENT SIGNAL ERROR TRAP FOR AN ANALYTE MEASUREMENT DETERMINED FROM A SPECIFIED SAMPLING TIME DERIVED FROM A SENSED PHYSICAL CHARACTERISTIC OF THE SAMPLE CONTAINING THE ANALYTE
Various embodiments for methods, systems, and meters that allow for a more accurate analyte concentration with a biosensor by determining at least one physical characteristic, particularly hematocrit, of the blood sample containing the analyte, particularly glucose, and deriving a specific sampling time based on a relationship between the physical characteristic, the estimated analyte concentration and sampling time. Afterthat determining whether at least one output transient signal of the biosensor is erroneous by monitoring the biosensor and flagging an error if the signal outputs of the biosensor do not meet certain criteria.
An analyte measurement system includes a processor connected to a biosensor providing analyte data corresponding to an analyte level of a fluid sample. A user interface provides a menu of functions to a user and successively receives a plurality of menu choices, which the processor records. A storage device holds data defining a first action criterion. The processor compares the menu choices to the first action criterion. When the stored menu choices satisfy the first action criterion, the processor can automatically add a first additional function to the menu of functions, or can automatically presents a reward token via the user interface. The system can also include a housing holding the user interface, the storage device, and the processor. Methods are also disclosed.
G06F 19/00 - Équipement ou méthodes de traitement de données ou de calcul numérique, spécialement adaptés à des applications spécifiques (spécialement adaptés à des fonctions spécifiques G06F 17/00;systèmes ou méthodes de traitement de données spécialement adaptés à des fins administratives, commerciales, financières, de gestion, de surveillance ou de prévision G06Q;informatique médicale G16H)
40.
FILL ERROR TRAP FOR AN ANALYTE MEASUREMENT DETERMINED FROM A SPECIFIED SAMPLING TIME DERIVED FROM A SENSED PHYSICAL CHARACTERISTIC OF THE SAMPLE CONTAINING THE ANALYTE
Various embodiments that allow for detection of a fill sufficiency and a more accurate analyte concentration by determining at least one physical characteristic, particularly hematocrit, of the blood sample containing the analyte, particularly glucose, and deriving a specific sampling time based on a relationship between the physical characteristic, the estimated analyte concentration and sampling time. In this way the analyte concentration can be determined with greater accuracy at the specific sampling time point and fill sufficiency can be determined if the signal outputs of the working electrodes do not meet certain thresholds.
Electrochemical-based analytical test strip with a soluble electrochemically-active coating opposite a bare electrode An electrochemical-based analytical test strip (EBATS) for the determination of an analyte in a bodily fluid sample includes an electrically insulating base layer, a patterned electrically conductive layer disposed on the electrically insulating base layer and including a plurality of electrodes, and an enzymatic reagent layer disposed on a portion of the patterned conductor layer and defining a bare electrode(s) and a plurality of enzymatic reagent covered electrodes from the plurality of electrodes. The EBATS also includes a patterned spacer layer, a top layer having an underside surface (USS), and a soluble electrochemically-active coating (SEAC) disposed on the USS of the top layer. In addition, at least the patterned spacer layer and top layer define a sample-receiving chamber within the EBATS. Furthermore, the SEAC is disposed on the USS of the top layer within at least a portion the sample-receiving chamber and in an opposing relationship to the bare electrodes.
C12Q 1/00 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions
A portable analytical test meter is designed for use with an associated analytical test strip. A test-strip-receiving module receives the analytical test strip and is electrically connected to a dummy load calibration circuit block. That block is configured to provide a dummy magnitude correction and a dummy phase correction; and a memory block is configured to store the dummy magnitude correction and the dummy phase correction. A method for calibrating a portable analytical test meter for use with an analytical test strip includes determining a dummy magnitude correction and a dummy phase correction of the portable analytical test meter using a dummy load calibration circuit block of the portable analytical test meter. The dummy magnitude correction and the dummy phase correction are stored in a memory block of the portable analytical test meter. Using the stored dummy magnitude correction and stored dummy phase correction, an analyte is determined.
A hand-held test meter for use with an analytical test strip in the determination of an analyte (for example, glucose)in a bodily fluid sample(such as a whole blood sample)includes a housing, a display module with a display illumination sub-module, a micro-controller disposed in the housing and a display illumination adjustment circuit block. The display illumination adjustment circuit block has a photo-sensor configured to sense ambient light levels and output a photo-sensor signal, a photo-sensor amplifier configured to receive the photo-sensor signal and output an amplified photo-sensor signal, a transfer function sub-block, and an illumination sub-module driver. The illumination sub-module driver is configured to drive the display illumination sub- module to illuminate the display module based on an illumination sub-module driver input signal.
G09G 3/34 - Dispositions ou circuits de commande présentant un intérêt uniquement pour l'affichage utilisant des moyens de visualisation autres que les tubes à rayons cathodiques pour la présentation d'un ensemble de plusieurs caractères, p. ex. d'une page, en composant l'ensemble par combinaison d'éléments individuels disposés en matrice en commandant la lumière provenant d'une source indépendante
Described are methods and systems to train a user in the proper operation of a manual drug delivery patch pump to ensure that the user can attach the patch pump to a suitable location on the skin and actuate the pump correctly in accordance with a prescribed dosing schedule or a self- calculated dosing schedule (502-512). The system includes a skin-adherable dummy patch pump with dummy actuators and a processor and memory, as well as a separate monitor device which receives data about actuation times from the dummy pump in order to enable comparison with the given dosing schedule.
A61M 5/142 - Perfusion sous pression, p. ex. utilisant des pompes
G06F 19/00 - Équipement ou méthodes de traitement de données ou de calcul numérique, spécialement adaptés à des applications spécifiques (spécialement adaptés à des fonctions spécifiques G06F 17/00;systèmes ou méthodes de traitement de données spécialement adaptés à des fins administratives, commerciales, financières, de gestion, de surveillance ou de prévision G06Q;informatique médicale G16H)
G09B 23/28 - Modèles à usage scientifique, médical ou mathématique, p. ex. dispositif en vraie grandeur pour la démonstration pour la médecine
45.
SYSTEM AND METHOD FOR QUICK-ACCESS PHYSIOLOGICAL MEASUREMENT HISTORY
Described are methods and systems to allow the use of a very simple physiological meter without a user input interface (i.e., buttonless) while maintaining the ability to store time linked measurement records for retrospective or prospective analysis of the measured physiological measurements with a bistable display to allow for a display of plural prior physiological measurements without necessitating the activation (e.g., turning on or manipulation of the user input interfaces) of the physiological meter.
G06F 19/00 - Équipement ou méthodes de traitement de données ou de calcul numérique, spécialement adaptés à des applications spécifiques (spécialement adaptés à des fonctions spécifiques G06F 17/00;systèmes ou méthodes de traitement de données spécialement adaptés à des fins administratives, commerciales, financières, de gestion, de surveillance ou de prévision G06Q;informatique médicale G16H)
46.
METHODS AND SYSTEMS TO DETERMINE FILL DIRECTION AND FILL ERROR IN ANALYTE MEASUREMENTS
Various embodiments for methods and systems that allow for detecting of a direction in which a sample is flowing towards a plurality of electrodes and detecting a fill error of an electrochemical test strip (100). This includes monitoring the working electrodes (8,9,10,12,14,15) such that it is possible to determine fill direction/ location by determining which electrode breaches a predetermined threshold first. This applies to systems with a plurality of electrodes in a number of orientations. Further, for systems which have analyte measurements along with physical characteristic measurement, it is also possible to achieve the same objectives by determining when each measurement (analyte measurement versus physical characteristic measurement) happens relative to the other. For test strips which can be filled from either side, the role of any electrode can change depending on the determination of fill direction. A measurement electrode can double up as a fill detect/full sufficiency electrode if it is determined that based on fill direction this electrode is now the last electrode in the chamber.
An electrochemical-based analytical test strip (EBATS) for the determination of an analyte (such as glucose) in a bodily fluid sample (for example, a whole blood sample) includes an electrically insulating base layer (110), a patterned electrically conductive layer (120) disposed on the electrically insulating base layer, an enzymatic reagent layer (140) disposed on the patterned electrically conductor layer, a patterned spacer layer (150), a top layer (170) having an underside surface, and a soluble acidic material coating (160) on the underside surface of the top layer. The patterned spacer layer and top layer define a sample-receiving chamber (180) within the EBATS and the soluble acidic material coating is disposed on the underside surface of the top layer within the sample-receiving chamber. In addition, the soluble acidic material coating is operably dissolvable in the bodily fluid sample such that a pH of the bodily fluid sample in the sample-receiving chamber is reduced during use of the EBATS.
C12Q 1/00 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions
An electrical connector (110) can receive a substrate (351) having conductive tracks (341, 342, 343, 344, 345). The connector includes a housing (120) with a port (129) and at least one alignment feature (121, 321) that together define a direction of insertion (125). At least three function pins (131, 132, 133, 134, 135) mounted to the housing each include contacts (141, 142, 143, 144, 145) that electrically connect to one of the conductive tracks of a substrate inserted in the connector. A sense pin (139) mounted to the housing has a contact (149) that electrically connects to at least one of the conductive tracks of an inserted substrate. The sense pin can include a plurality of electrically-connected segments, each segment extending substantially parallel or substantially perpendicular to the direction of insertion of the substrate. Systems and methods for detecting an analyte in a bodily-fluid sample are also described.
The invention provides dispensers for sensors. The dispensers of the invention are capable of storing a plurality of sensors and dispensing them one-by-one. The dispenser comprises a housing, a lid and a sensor cartridge with a stack of sensors biased towards the lid. The lid comprises a pusher. While the lid is moved from a closed to an open position the pusher engages the uppermost sensor and pushes it from a storage position to a dispensed position.
G01N 33/487 - Analyse physique de matériau biologique de matériau biologique liquide
B65D 83/08 - Réceptacles ou paquets comportant des moyens particuliers pour distribuer leur contenu pour distribuer à la file des articles minces et plats
B65D 83/04 - Réceptacles ou paquets comportant des moyens particuliers pour distribuer leur contenu pour distribuer de petits objets en forme d'anneau, de disque, de sphère ou similaire, p. ex. des comprimés ou des pilules
50.
ELECTROCHEMICAL-BASED ANALYTICAL TEST STRIP WITH BARE INTERFERENT ELECTRODES
An electrochemical-based analytical test strip ("TS") for the determination of an analyte in a bodily fluid sample includes an electrically insulating substrate, a patterned conductor layer disposed over the electrically-insulating substrate and having an analyte working electrode("WE"), a bare interferent electrode ("IE") and a shared counter/reference electrode("CE"). The TS also includes a patterned insulation layer ("PIL") with an electrode exposure slot configured to expose the WE, IE and CE, an enzymatic reagent layer disposed on the WE and CE, and a patterned spacer layer ("PSL"). The PIL and the PSL define a sample receiving chamber with a sample-receiving opening. The IE and the CE constitute a first electrode pair configured for measurement of an interferent electrochemical response and the WE and the CE constitute a second electrode pair configured for measurement of an analyte electrochemical response. The WE and the IE are electrically isolated from one another.
C12Q 1/02 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des micro-organismes viables
G01N 33/487 - Analyse physique de matériau biologique de matériau biologique liquide
51.
SYSTEM AND METHODS TO ACCOUNT FOR INTERFERENTS IN A GLUCOSE BIOSENSOR
Various embodiments that allow for improved accuracy in the measurement of glucose with a glucose meter and a biosensor, principally, by using pulsed signal inputs to the biosensor and selecting at least one specific pulsed output from the biosensor to determine a glucose concentration that is less affected by interfering chemical substances that might be present in the fluid sample.
An analytical test strip for the determination of an analyte (such as glucose and/or hematocrit) in a bodily fluid sample (such as a whole blood sample) includes a first capillary sample-receiving chamber, a second capillary sample-receiving chamber, and a physical barrier island disposed between the first and second capillary sample-receiving chambers. Moreover, the physical island barrier is disposed such that bodily fluid sample flow between the first capillary sample-receiving chamber and the second capillary sample-receiving chamber is prevented during use of the analytical test strip.
An analytical test strip for the determination of an analyte (such as glucose) in a bodily fluid sample (e.g., a whole blood sample) includes a first and second capillary sample-receiving chambers and first and second stop junctions that are disposed between the first and second capillary sample-receiving chambers. The first stop junction defines a discontinuity boundary of the first capillary sample-receiving chamber and the second stop junction defines a discontinuity boundary of the second capillary sample-receiving chamber. In addition, the first stop junction and the second stop junction are disposed such that bodily fluid sample flow between the first capillary sample-receiving chamber and the second capillary sample-receiving chamber during use of the analytical test strip is prevented.
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
54.
ELECTROCHEMICAL-BASED ANALYTICAL TEST STRIP WITH INTERSECTING SAMPLE-RECEIVING CHAMBERS
An electrochemical-based analytical test strip for the determination of an analyte (such as glucose) in a bodily fluid sample (for example, a whole blood sample) and/or a characteristic of the bodily fluid sample (for example, hematocrit) includes a first sample-receiving chamber with first and second sample-application openings, and first and second electrodes. The first and second electrodes are disposed in the first sample-receiving chamber between the first and second sample-application openings. The electrochemical-based analytical test strip also includes a second sample- receiving chamber and a plurality of electrodes disposed in the second sample-receiving chamber. In addition, the second sample-receiving chamber intersects the first sample-receiving chamber between the first and second electrodes, thereby defining a chamber intersection.
C12Q 1/00 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions
55.
ELECTROCHEMICAL-BASED ANALYTICAL TEST STRIP WITH INTERSECTING SAMPLE-RECEIVING CHAMBERS
An electrochemical-based analytical test strip for the determination of an analyte (such as glucose) in a bodily fluid sample (for example, a whole blood sample) and/or a characteristic of the bodily fluid sample (for example, hematocrit) includes a first sample-receiving chamber with first and second sample-application openings, and first and second electrodes. The first and second electrodes are disposed in the first sample-receiving chamber between the first and second sample-application openings. The electrochemical-based analytical test strip also includes a second sample-receiving chamber and a plurality of electrodes disposed in the second sample-receiving chamber. In addition, the second sample-receiving chamber intersects the first sample-receiving chamber between the first and second electrodes, thereby defining a chamber intersection.
C12Q 1/00 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions
56.
ENZYMATIC ELECTROCHEMICAL-BASED SENSORS WITH NAD POLYMERIC COENZYME
A nicotinamide adenine dinucleotide (NAD) polymeric coenzyme for use in enzymatic electrochemical-based sensors includes NAD moieties covalently bound as pendent groups to a polymer backbone. An enzymatic electrochemical-based biosensor includes nicotinamide adenine dinucleotide (NAD) polymeric coenzyme, a polymeric electron transfer agent (e.g., polymeric ferrocene) at least one working electrode, and at least one reference electrode.
C12Q 1/00 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions
57.
BATTERY STATUS DETECTION AND STORAGE METHOD AND SYSTEM IN MEDICAL MONITORING
Described herein are systems and methods to determine when a new or fresh battery has been replaced in a medical monitoring device and store a record of such battery replacement so that the battery records of the medical monitoring device can be reliably kept over the life of the monitoring device.
A biosensor (such as an electrochemical-based analytical test strip configured for the determination of glucose in a whole blood sample) includes a substrate, an electrode disposed on the substrate and a uric acid scavenger layer containing polymeric vinyl-4,6-diamino-1,3,5-triazine (polyVDAT) nanoparticles. Aqueous compositions useful in, for example, the manufacturing of such biosensors include polyVDAT nanoparticles and water with the polyVDAT nanoparticles being present as a dispersion in the water. A method for determining an analyte in a bodily fluid sample containing uric acid includes applying a bodily fluid sample containing uric acid to a biosensor such that the bodily fluid sample comes into contact with a uric acid scavenger layer containing polymeric vinyl-4,6-diamino-1,3,5-triazine (polyVDAT) nanoparticles and determining the analyte based on an electronic signal produced by the biosensor.
C12Q 1/00 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions
An electrochemical-based analytical test strip ("EBAT") for the determination of an analyte in a bodily fluid sample includes an electrically insulating substrate layer with a distal end and a patterned conductor layer that is disposed over the electrically-insulating substrate layer and has a working electrode ("WE") and a counter/reference electrode ("C/RE"). The EBAT also includes a patterned insulation layer with an electrode exposure window configured to expose a WE exposed portion and a C/RE exposed portion, an enzymatic reagent layer; and a patterned spacer layer. In addition, the patterned insulation layer and the patterned spacer layer define a sample receiving chamber with a sample-receiving opening at the distal end of the electrically insulating substrate layer and that extends across the WE exposed portion and the C/RE exposed portion. Furthermore, the enzymatic reagent layer is disposed over the working electrode and counter/reference electrode exposed portions and extends no more than 400µm toward the sample-receiving opening.
C12Q 1/00 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions
60.
ACCURATE ANALYTE MEASUREMENTS FOR ELECTROCHEMICAL TEST STRIP BASED ON SENSED PHYSICAL CHARACTERISTIC(S) OF THE SAMPLE CONTAINING THE ANALYTE
Glucose concentration determination with a biosensor by determining at least one physical characteristic of the blood sample, typically hematocrit percentage, and deriving one of a batch slope, a sampling time, or combinations thereof to attain glucose concentration.
ACCURATE ANALYTE MEASUREMENTS FOR ELECTROCHEMICAL TEST STRIP BASED ON MULTIPLE DISCRETE MEASUREMENTS DEFINED BY SENSED PHYSICAL CHARACTERISTIC(S) OF THE SAMPLE CONTAINING THE ANALYTE
Various embodiments that allow for a more accurate analyte concentration by determining at least one physical characteristic, particularly hematocrit, of the blood sample containing the analyte, particularly glucose, and deriving a specific sampling time based on a relationship between the physical characteristic and sampling time so that the analyte concentration can be determined with greater accuracy with the specific sampling time point.
ACCURATE ANALYTE MEASUREMENTS FOR ELECTROCHEMICAL TEST STRIP BASED ON MULTIPLE DISCRETE MEASUREMENTS DEFINED BY SENSED PHYSICAL CHARACTERISTIC(S) OF THE SAMPLE CONTAINING THE ANALYTE
Various embodiments that allow for a more accurate analyte concentration by determining at least one physical characteristic, particularly hematocrit, of the blood sample containing the analyte, particularly glucose, and deriving a specific sampling time based on a relationship between the physical characteristic and sampling time so that the analyte concentration can be determined with greater accuracy with the specific sampling time point.
Glucose concentration determination with a biosensor by determining at least one physical characteristic of the blood sample, typically hematocrit percentage, and deriving one of a batch slope, a sampling time, or combinations thereof to attain glucose concentration.
ACCURATE ANALYTE MEASUREMENTS FOR ELECTROCHEMICAL TEST STRIP BASED ON SENSED PHYSICAL CHARACTERISTIC(S) OF THE SAMPLE CONTAINING THE ANALYTE AND DERIVED BIOSENSOR PARAMETERS
Various embodiments for a method that allow for a more accurate analyte concentration with a biosensor by determining at least one physical characteristic, typically hematocrit, of the sample containing the analyte and deriving from this characteristic a parameter relating to the biosensor to attain accurate glucose concentration.
A hand-held test meter for use with an analytical test strip in the determination of an analyte (such as glucose) in a bodily fluid sample (e.g., a whole blood sample) includes a housing, with an outer surface, and an analytical test strip ejection mechanism ("ATSEM"). The ATSEM has an actuation button disposed in the outer surface of the housing, a motion amplification and rotation assembly ("MA&RA") operatively connected to the actuation button and a test strip slider operatively connected to the MA&RA. The actuation button is configured for movement by a user's digit in a first direction and the MA&RA and test strip slider are configured to convert the movement in the first direction into amplified movement of the test strip slider in a second direction with the second direction being rotated with respect to the first direction. In addition, the test strip slider is further configured for operative engagement with an analytical test strip inserted into the hand-held test meter in an engaged state such that movement of the test strip slider in the second direction from the engaged state to an ejected state ejects the analytical test strip from the hand-held test meter.
A hand-held test meter for use with an analytical test strip in the determination of an analyte in a bodily fluid sample includes a housing (110); a microcontroller block (112) disposed in the housing; and a phase-shift-based hematocrit measurement block (114). The phase- shift-based hematocrit measurement block includes a signal generation sub-block (120), a low pass filter sub-block (122), an analytical test strip sample cell interface sub-block (124), a transimpedance amplifier sub-block (128), and a phase detector sub-block (130). In addition, the phase-shift-based hematocrit measurement block and microcontroller block are configured to measure the phase shift of a bodily fluid sample in a sample cell of an analytical test strip inserted in the hand-held test meter and the microcontroller block is configured to compute the hematocrit of the bodily fluid sample based on the measured phase shift.
An analytical test strip ("ATS") for use with a hand-held test meter in the determination of an analyte in a bodily fluid sample includes an electrically insulting substrate (102), a first patterned conductor layer (104) disposed on the electrically insulating substrate and having a working electrode (128a, 128b) and a reference electrode (130). The ATS also includes an enzymatic reagent layer (106) disposed on the working electrode, a first patterned spacer layer (108) disposed over the first patterned conductor layer and defining both a first sample-receiving channel (112) and an analyte determination sample chamber (114) within the ATS, and a second patterned spacer layer (110) disposed over the first patterned spacer layer and defining at least a second sample-receiving channel (120). The ATS further includes a bodily fluid phase-shift sample chamber (116) in fluidic communication with the second sample-receiving channel. The first sample-receiving channel (112) and analyte determination sample chamber (114) are isolated from the second sample-receiving channel (120) and bodily fluid phase-shift sample chamber (116).
An analytical test strip ("ATS") for use with a hand-held test meter ("HHTM") in the determination of an analyte in a bodily fluid sample ("BFS") includes a first patterned conductive layer with a working electrode and a reference electrode, as well as a method for determining an analyte in BFS. The ATS also includes an enzymatic reagent layer disposed on the working electrode, a patterned spacer layer disposed over the first patterned conductive layer and configured to define a sample chamber ("SC") within the ATS, and a second patterned conductive layer disposed above the first patterned conductive layer. The second patterned conductive layer includes a first phase-shift measurement electrode and a second phase-shift measurement electrode, which electrodes are disposed in the SC and are configured to measure, along with the HHTM, a phase shift of an electrical signal forced through a BFS introduced into the SC during the ATS' use.
Various embodiments that allow for determination of hematocrit by a time differential between the input and output signals such that a glucose measurement for a blood sample can be corrected by the measured hematocrit of the blood sample.
Two techniques of determining hematocrit using impedance and phase angle to determine hematocrit are shown and described for correcting an analyte concentration.
Measurement with a test strip having two working electrodes (12, 14), using the current transient (402, 404) for each working electrode measured at a predetermined durational offset (Tpred1, Tpred2) from a peak (408, 410) of the current transient.
Measurement with a test strip having two working electrodes (12, 14), using the current transient (402, 404) for each working electrode measured at a predetermined durational offset (Tpred1, Tpred2) from a peak (408, 410) of the current transient.
A method and system are provided to determine fill sufficiency of an electrochemical biosensor test cell by determining capacitance of the electrochemical test cell.
G01N 27/22 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance en recherchant la capacité
G01N 33/487 - Analyse physique de matériau biologique de matériau biologique liquide
74.
CAPACITANCE DETECTION IN ELECTROCHEMICAL ASSAY WITH IMPROVED RESPONSE
G01N 33/487 - Analyse physique de matériau biologique de matériau biologique liquide
G01N 27/22 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance en recherchant la capacité
75.
SERVER-SIDE INITIATED COMMUNICATION WITH ANALYTE METER-SIDE COMPLETED DATA TRANSFER
G06F 19/00 - Équipement ou méthodes de traitement de données ou de calcul numérique, spécialement adaptés à des applications spécifiques (spécialement adaptés à des fonctions spécifiques G06F 17/00;systèmes ou méthodes de traitement de données spécialement adaptés à des fins administratives, commerciales, financières, de gestion, de surveillance ou de prévision G06Q;informatique médicale G16H)
76.
GLUCOSE ELECTROCHEMICAL MEASUREMENT METHOD WITH ERROR DETECTION
Described and illustrated herein are systems and exemplary methods of operating an analyte measurement system having a meter and a test strip. The methods and systems describe herein allow for trapping various errors during calculation of the analyte due to variations in the structure and materials making up the test strip and ambient temperatures.
C12Q 1/00 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions
Described and illustrated herein are systems and exemplary methods of operating an analyte measurement system having a meter and a test strip. In one embodiment, the method may be achieved by applying a first test voltage between a reference electrode and a second working electrode and applying a second test voltage between the reference electrode and a first working electrode; measuring a first test current, a second test current, a third test current and a fourth test current at the second working electrode after a blood sample containing an analyte is applied to the test strip;; measuring a fifth test current at the first working electrode; estimating a hematocrit- corrected analyte concentration from the first, second, third, fourth and fifth test currents; and annunciating the hematocrit-corrected analyte concentration.
A61B 5/1486 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang en utilisant des procédés chimiques ou électrochimiques, p. ex. par des moyens polarographiques en utilisant des électrodes enzymatiques, p. ex. avec oxydase immobilisée
G01N 33/487 - Analyse physique de matériau biologique de matériau biologique liquide
78.
ENZYMATIC REAGENT INKS FOR USE IN TEST STRIPS HAVING A PREDETERMINED CALIBRATION CODE
The invention provides an enzyme ink useful in test strips that provides a test strip bias, at the low and high glucose ends, falling within a desired target range. The ink of the invention permits an improved method for the production of single calibration code strip lots with good yields.
G01N 33/49 - Analyse physique de matériau biologique de matériau biologique liquide de sang
C12Q 1/00 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions
G01N 27/30 - Électrodes, p. ex. électrodes pour testsDemi-cellules
79.
METHODS TO ENSURE STATISTICAL POWER FOR AVERAGE PRE AND POST - PRANDIAL GLUCOSE DIFFERENCE MESSAGING
A diabetes management system and method are provided herein that may be used to analyze a patient's level of control of their diabetes, by looking at the difference between blood glucose measurements taken before and after a meal. If the standard deviation of the differences D calculated between pre- and post-prandial results is found to vary significantly from a predetermined threshold value, then a message or graphical indication may be displayed to the user. Messages may provide suggestions to the user as to ways to better manage their condition to ensure compliance of any prescribed diabetes regimen or to guide the patient in managing their diabetes.
A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
G06F 19/00 - Équipement ou méthodes de traitement de données ou de calcul numérique, spécialement adaptés à des applications spécifiques (spécialement adaptés à des fonctions spécifiques G06F 17/00;systèmes ou méthodes de traitement de données spécialement adaptés à des fins administratives, commerciales, financières, de gestion, de surveillance ou de prévision G06Q;informatique médicale G16H)
80.
ANALYTICAL TEST STRIP WITH CROSSROADS EXPOSED ELECTRODE CONFIGURATION
An electrochemical -based analytical test strip (10) for the determination of an analyte (such as glucose) in a bodily fluid sample (for example, whole blood) includes an electrically insulating base layer (12), a patterned conductor layer (14) disposed over the electrically- insulating layer, and a patterned insulation layer (16), with an electrode exposure window (18) therethrough, disposed over the patterned conductor layer. The patterned conductive layer of the electrochemical -based analytical test strip includes at least one working electrode (14a, 14c) and a counter/reference electrode (14b). In addition, at least a portion of the electrode exposure window is configured to expose a working electrode exposed portion and a counter/reference electrode exposed portion, with the working electrode exposed portion being rectangular in shape and the counter/reference electrode exposed portion being one of a crossroads shape and an at least six-sided portion of a crossroads shape.
G01N 33/487 - Analyse physique de matériau biologique de matériau biologique liquide
C12Q 1/54 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir le glucose ou le galactose
81.
ANALYTICAL TEST STRIP WITH AN ELECTRODE HAVING ELECTROCHEMICALLY ACTIVE AND INERT ARES OF A PREDETERMINED SIZE AND DISTRIBUTION
An electrochemical -based analytical test strip (10) for the determination of an analyte (e.g., glucose) in a bodily fluid sample (such as a whole blood sample) includes an electrically insulating base layer (12) and a patterned conductor layer (14) (for example, a gold patterned conductor layer) disposed over the electrically-insulating layer (12). The patterned conductor layer (14) includes at least one electrode (14a, 14b, 14c) with the electrode (14a, 14b, 14c) having electrochemically inert areas (26) and an electrochemically active area(s) (28). Moreover, the electrochemically inert areas (26) and electrochemically active area(s) (28) are of a predetermined size and a predetermined distribution such that electrochemical response of the electrode (14a, 14b, 14c) during use of the electrochemical -based analytical test strip (10) is essentially equivalent to a predetermined electrochemical response.
G01N 33/49 - Analyse physique de matériau biologique de matériau biologique liquide de sang
G01N 33/487 - Analyse physique de matériau biologique de matériau biologique liquide
G01N 27/26 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant des variables électrochimiquesRecherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en utilisant l'électrolyse ou l'électrophorèse
82.
ELECTROCHEMICAL ANALYTE MEASUREMENT METHOD AND SYSTEM
Described and illustrated herein are systems and exemplary methods of operating an analyte measurement system having a meter and a test strip. In one embodiment, the method may be achieved by applying a first test voltage between a reference electrode and a second working electrode and applying a second test voltage between the reference electrode and a first working electrode; measuring a first test current, a second test current, a third test current and a fourth test current at the second working electrode after a blood sample containing an analyte is applied to the test strip;; measuring a fifth test current at the first working electrode; estimating a hematocrit- corrected analyte concentration from the first, second, third, fourth and fifth test currents; and annunciating the hematocrit-corrected analyte concentration.
G01N 27/49 - Systèmes impliquant la détermination du courant à une valeur unique spécifique, ou dans une petite plage de valeurs, pour une tension appliquée afin de produire la mesure sélective d'une ou plusieurs espèces ioniques particulières
G01N 33/487 - Analyse physique de matériau biologique de matériau biologique liquide
83.
ANALYTE TESTING METHOD AND SYSTEM WITH HIGH AND LOW BLOOD GLUCOSE TRENDS NOTIFICATION
Described is a method and system for notifying a user of a high trend in blood glucose values. If a most recent blood glucose measurement is above a pre-determined high threshold and is tagged as either a measurement before a meal or made during a fasting period, then whether there are two or more measurements stored in memory over the previous N number of days above the pre-determined high threshold is determined. If the two or more measurements were tagged as being either a measurement before a meal, during a fasting period, or both, then it is determined whether the most recent measurement and the two or more measurements were performed within a time frame of approximately X hours that brackets the given time during each day but over prior days. Upon evaluation that the measurements were performed within the time frame, then a high trend warning is annunciated.
A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
G16H 50/70 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour extraire des données médicales, p. ex. pour analyser les cas antérieurs d’autres patients
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
Described herein are systems and methods to utilize factual information based on stored blood glucose data to allow greater insight into the management of diabetes of a user.
G06F 19/00 - Équipement ou méthodes de traitement de données ou de calcul numérique, spécialement adaptés à des applications spécifiques (spécialement adaptés à des fonctions spécifiques G06F 17/00;systèmes ou méthodes de traitement de données spécialement adaptés à des fins administratives, commerciales, financières, de gestion, de surveillance ou de prévision G06Q;informatique médicale G16H)
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
86.
ANALYTE TESTING METHOD AND SYSTEM WITH SAFETY WARNINGS FOR INSULIN DOSING
Methods and systems to provide for safeguards in the insulin dosing calculation as part of the diabetes management. The system or method provides a warning if the person with diabetes is calculating a dosing regimen outside of a preselected time period in which certain dosing parameters are customized to the preselected time period.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61M 5/14 - Dispositifs de perfusion, p. ex. perfusion par gravitéPerfusion sanguineAccessoires à cet effet
G06F 19/00 - Équipement ou méthodes de traitement de données ou de calcul numérique, spécialement adaptés à des applications spécifiques (spécialement adaptés à des fonctions spécifiques G06F 17/00;systèmes ou méthodes de traitement de données spécialement adaptés à des fins administratives, commerciales, financières, de gestion, de surveillance ou de prévision G06Q;informatique médicale G16H)
87.
SHAPE MEMORY ALLOY EJECTION MECHANISM FOR EJECTING A TEST STRIP FROM A TEST METER
A method for ejecting a test strip from a test meter includes initiating activation of a test strip ejection mechanism that is in a pre-ejection state. In the method, the test strip ejection mechanism includes a shape memory alloy strip that exhibits a solid state transition temperature and has a programmed configuration and a deformed configuration. In the test strip ejection mechanism pre-ejection state, a test strip has been received within a test strip receiving port of the test meter and the shape memory alloy strip is in the deformed configuration. The method also includes heating, in response to the initiation step, the shape memory alloy strip from below the solid state transition temperature to above the solid state transition temperature. The heating results in the shape memory alloy strip undergoing a transformation from the deformed configuration to the programmed configuration. The method also includes applying a force produced by the transformation from the deformed configuration to the programmed configuration to the test strip and, thereby, ejecting the test strip from the test strip receiving port.
A test strip ejection mechanism, for use with a test strip receiving port and a test strip, includes a framework, an elongated shape memory alloy (SMA) strip (e.g., a SMA wire), a slider, and a heating module. The SMA strip has first and second ends that are attached to the framework and exhibits a solid state transition temperature. The slider is configured to travel along the framework. The heating module is configured to heat the SMA strip from a temperature below the solid state transition temperature to a temperature above the solid state transition temperature. Moreover, the SMA strip and slider are configured such that the slider travels along the framework under an applied force exerted on the slider by the SMA strip as the shape memory strip is heated from a temperature below the solid state transition temperature to a temperature above the solid state temperature by the heating module. In addition, the slider has a proximal end configured to engage a test strip received within a test strip receiving port and eject the test strip from the test strip receiving port as the slider travels along the framework. A test meter for use with a test strip includes a test strip receiving port and a test strip ejection mechanism.
Described and illustrated herein are one exemplary method and a measurement system having a meter and a test strip. The test strip has a first working electrode, reference electrode and second working electrode. In this method, acceptable fill data from known first current and known second current are used to predict an estimated second current at proximate the second time period (for a given batch of test strips) during the test sequence. The estimated second current at proximate the second time interval is then compared with a measured actual second current at proximate the second time interval during an actual test to determine if the measured actual second current is substantially equal to or within an acceptable percent deviation. from the estimated second current so as to determine sufficient volume of a physiological fluid sample in the test strip.
G01N 33/66 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir les sucres du sang, p. ex. le galactose
90.
ANALYTE TESTING METHOD AND DEVICE FOR DIABETES MANAGEMENT
Various embodiments are described and illustrated to calculate an insulin bolus, recommend such bolus, and provide reminder messages for performing an additional glucose test.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
G16H 20/10 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p. ex. pour s’assurer de l’administration correcte aux patients
G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
A61M 5/172 - Moyens pour commander l'écoulement des agents vers le corps ou pour doser les agents à introduire dans le corps, p. ex. compteurs de goutte-à-goutte électriques ou électroniques
91.
ANALYTE TESTING METHOD AND DEVICE FOR DIABETES MANAGEMENT
Methods of managing blood glucose values of a diabetic user are provided with an analyte measurement and management device. The method comprises conducting glucose measurements from the user's physiological fluids of a user; verifying whether a most recent glucose measurement was made within a first predetermined time period; determining an insulin bolus for delivery to the user based on at least one of the plurality of blood glucose measurement values, insulin sensitivity of the user, insulin to carbohydrate ratio, and target glucose value; and reminding the user to conduct a glucose measurement within a second predetermined time period whenever a glucose measurement from the user's physiological fluid indicates an abnormal glucose value.
A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61M 5/172 - Moyens pour commander l'écoulement des agents vers le corps ou pour doser les agents à introduire dans le corps, p. ex. compteurs de goutte-à-goutte électriques ou électroniques
92.
ANALYTE TESTING METHOD AND DEVICE FOR DIABETES MANAGEMENT
Various embodiments are described and illustrated to calculate an insulin bolus, recommend such bolus, and provide reminder messages for performing an additional glucose test.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
G06F 19/00 - Équipement ou méthodes de traitement de données ou de calcul numérique, spécialement adaptés à des applications spécifiques (spécialement adaptés à des fonctions spécifiques G06F 17/00;systèmes ou méthodes de traitement de données spécialement adaptés à des fins administratives, commerciales, financières, de gestion, de surveillance ou de prévision G06Q;informatique médicale G16H)
Described and illustrated herein are systems and exemplary methods of operating a multianalyte measurement system having a meter and a test strip. In one embodiment, the method may be achieved by applying a test voltage between a reference electrode and a first working electrode; measuring a first test current, a second test current and a third test current at the working electrode with the meter after a blood sample containing an analyte is applied to the test strip; estimating a hematocrit-corrected analyte concentration from the first, second and third test currents; and displaying the hematocrit-corrected analyte concentration.
Method of determining a type of a test strip in a glucose meter, the method comprising: (a) inserting a test strip into a strip port connector of the glucose meter, the strip port connector having first, second and third discrete contacts; (b) determining whether there is a continuity between a first contact and a second contact that are in electrical connection with at least one contact pad of the test strip; (c) evaluating whether there is a continuity between a third contact and the first contact or between the third contact and the second contact that are in electrical connection with one or more contact pads of the test strip; (d) initiating a glucose test upon detection of continuity in the determining and evaluating. Glucose meter comprising: a strip connector having first, second and third contacts, the third contact connected to a ground; a switch having a source input, a drain input and a gate input, the source input connected to a ground, the drain input connected to the first contact; and a microcontroller having a first interrupt connected to the gate input of the switch and a second interrupt connected to the second contact, the microcontroller being in electrical communication with the first contact and the third contact upon insertion of a test strip.
Described herein are systems and methods to utilize factual information based on stored blood glucose data to allow greater insight into the management of diabetes of a user.
G06F 19/00 - Équipement ou méthodes de traitement de données ou de calcul numérique, spécialement adaptés à des applications spécifiques (spécialement adaptés à des fonctions spécifiques G06F 17/00;systèmes ou méthodes de traitement de données spécialement adaptés à des fins administratives, commerciales, financières, de gestion, de surveillance ou de prévision G06Q;informatique médicale G16H)
96.
MEDICAL DEVICE WITH AUTOMATIC TIME AND DATE CORRECTION
Various exemplary embodiments of methods and apparatuses are described and illustrated in which time and date of are provided to a medical device via wireless signals to ensure accurate time keeping by the medical device.
G06F 19/00 - Équipement ou méthodes de traitement de données ou de calcul numérique, spécialement adaptés à des applications spécifiques (spécialement adaptés à des fonctions spécifiques G06F 17/00;systèmes ou méthodes de traitement de données spécialement adaptés à des fins administratives, commerciales, financières, de gestion, de surveillance ou de prévision G06Q;informatique médicale G16H)
G04G 5/00 - Mise à l'heure, c.-à-d. correction ou changement de l'indication de l'heure
G09G 3/36 - Dispositions ou circuits de commande présentant un intérêt uniquement pour l'affichage utilisant des moyens de visualisation autres que les tubes à rayons cathodiques pour la présentation d'un ensemble de plusieurs caractères, p. ex. d'une page, en composant l'ensemble par combinaison d'éléments individuels disposés en matrice en commandant la lumière provenant d'une source indépendante utilisant des cristaux liquides
Described and illustrated herein is an exemplary method of operating an analyte measurement device having a display, user interface, processor, memory, and user interface buttons. Such method can be achieved by measuring an analyte with the analyte measurement device, displaying a value representative of the analyte, querying a user to select a predetermined flag to associate the predetermined flag with the value, and pressing only one of the user interface buttons once to store the predetermined flag with the value in the memory of the analyte measurement device. In one embodiment, the testing device is a glucose meter and the analyte being tested is glucose.
G01N 37/00 - Détails non couverts par les autres groupes de la présente sous-classe
G01N 33/66 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir les sucres du sang, p. ex. le galactose
99.
PRIME AND FIRE LANCING DEVICE WITH CONTACT BIAS DRIVE AND METHOD
Described and illustrated herein is an exemplary lancing device. The lancing device includes a first housing, second housing, movable member, lancet, and lancet depth adjustment member. The lancet depth adjustment member is captured by both the first and second housings so that the lancet depth adjustment member is rotatable relative to both housings to provide for a plurality of stop surfaces to the movable member. Other exemplary embodiments are also described.
Described and illustrated herein is an exemplary lancing device. The lancing device includes a first housing, second housing, movable member, lancet, and lancet depth adjustment member. The lancet depth adjustment member is captured by both the first and second housings so that the lancet depth adjustment member is rotatable relative to both housings to provide for a plurality of stop surfaces to the movable member. Other exemplary embodiments are also described.
brevets
