Abrégé

155 are deuterium, and the rest is hydrogen. The synthesis method comprises the step of oxidizing an intermediate B with m-chloroperoxybenzoic acid to prepare the deuterated tinidazole, wherein the oxidation is carried out under low-temperature and alkaline conditions; and the intermediate B is as represented by formula II. By using the synthesis method of the present invention, the problems of deuterium shedding and isotope dilution in the reaction process can be avoided, and the stable isotope-labeled deuterated tinidazole with the isotope abundance of > 98% is obtained with a higher yield. The prepared deuterated tinidazole can be used as an isotope internal standard reagent for the quantitative detection of tinidazole, which, for example, can be used to detect residual tinidazole in meat products by means of an isotope internal standard method, and has the advantages of having high recovery efficiency from a matrix, and being environmentally friendly and safe.

Classes IPC  ?

• C07D 233/94 - Radicaux nitro liés en position 4 ou 5 avec des radicaux hydrocarbonés, substitués par des atomes d'oxygène ou de soufre, liés aux autres chaînons du cycle
• C07B 59/00 - Introduction d'isotopes d'éléments dans les composés organiques

Abrégé

The present invention relates to a solid-phase extraction column filler. The solid-phase extraction column filler comprises: a microsphere body formed by copolymerization of several reaction monomers and several crosslinking monomers, and several graft monomers grafted on the surface of the microsphere body, wherein the reaction monomers are selected from acrylic acid; the cross-linking monomers are selected from at least one of divinyl benzene, diethylene glycol diacrylate, triethylene glycol diacrylate, and trimethylolpropane trimethacrylate; and the graft monomers are selected from heparin. According to the preparation method of the present invention, the acrylic acid is used as the reaction monomers and is copolymerized with the crosslinking monomers to generate the microsphere body; and then condensation grafting is carried out by means of a carboxyl functional group on the acrylic acid and an amino functional group of the heparin, such that preparation of the solid-phase extraction column filler is achieved, and the carboxyl functional group having electronegativity, a sulfonic acid group functional group of the heparin and the carboxyl functional group of the heparin can synergistically adsorb lactoferrin.

Classes IPC  ?

• B01J 20/26 - Composés macromoléculaires synthétiques

Abrégé

Disclosed in the present invention is a synthesis method for stable-isotope labeled thiamphenicol and thiamphenicol amine. The synthesis method uses thiamphenicol as a raw material, and comprises performing hydrolysis to obtain thiamphenicol amine, carrying out hydrogen-deuterium exchange under an alkaline condition to obtain stable-isotope labeled thiamphenicol amine, and further carrying out acylation to obtain stable-isotope labeled thiamphenicol. The synthesis method involves a short synthesis route, high atom utilization rate, high yields and cheap and easily available raw materials. The chemical purity and the deuterium isotope abundance of the prepared stable-isotope labeled thiamphenicol and thiamphenicol amine both reach 98.0% or higher, and therefore the prepared stable-isotope labeled thiamphenicol and thiamphenicol amine can be used as isotope internal standard substances for measurement of thiamphenicol residues in foods.

Classes IPC  ?

• C07C 315/04 - Préparation de sulfonesPréparation de sulfoxydes par des réactions n'impliquant pas la formation de groupes sulfone ou sulfoxyde
• C07C 317/32 - SulfonesSulfoxydes ayant des groupes sulfone ou sulfoxyde et des atomes d'azote, ne faisant pas partie de groupes nitro ou nitroso, liés au même squelette carboné avec des groupes sulfone ou sulfoxyde liés à des atomes de carbone de cycles aromatiques à six chaînons du squelette carboné

Abrégé

A synthesis method for stable-isotope labeled florfenicol and florfenicol amine. The method uses florfenicol as a raw material, and comprises hydrolyzing same to obtain florfenicol amine, performing hydrogen-deuterium exchange under an alkaline condition to obtain stable-isotope labeled florfenicol amine, and further performing acylation to obtain stable-isotope labeled florfenicol. The synthesis method involves a short synthesis route, high atom utilization rate, high yield and cheap and easily available raw materials. The chemical purity and deuterium isotope abundance of the prepared stable-isotope labeled florfenicol and florfenicol amine both reach 98.0% or higher, and therefore the stable-isotope labeled florfenicol and florfenicol amine can be used as isotope internal standard substances for analysis and detection.

Classes IPC  ?

• C07C 315/04 - Préparation de sulfonesPréparation de sulfoxydes par des réactions n'impliquant pas la formation de groupes sulfone ou sulfoxyde
• C07C 317/32 - SulfonesSulfoxydes ayant des groupes sulfone ou sulfoxyde et des atomes d'azote, ne faisant pas partie de groupes nitro ou nitroso, liés au même squelette carboné avec des groupes sulfone ou sulfoxyde liés à des atomes de carbone de cycles aromatiques à six chaînons du squelette carboné
• C07B 59/00 - Introduction d'isotopes d'éléments dans les composés organiques

Produits et services

Glass bulbs (receptacles); glass vials (receptacles); glass flasks (containers); glass jars (carboys).

Produits et services

Hydrometers; pressure measuring apparatus; chemistry apparatus and instruments; measuring glassware; precision measuring apparatus; air analysis apparatus; gas testing instruments; ovens for laboratory use; chromatography apparatus for laboratory use; viscosimeters.

Produits et services

Containers for household use, namely, glass bulbs; glass vials being receptacles for medication sold empty; glass flasks; glass jars being carboys

Produits et services

Hydrometers; pressure measuring apparatus; chemistry apparatus and instruments, namely, laboratory apparatus and instruments for the exchange of substances and heat; measuring glassware; precision measuring apparatus, namely, precision pressure measuring apparatus; air analysis apparatus; gas testing instruments; ovens for laboratory use; chromatography apparatus for laboratory use; viscosimeters