Disclosed is a method for diagnosing a neurodegenerative disease in a subject. The method comprises obtaining from the subject a sample comprising at least one live blood cell, and optionally isolating at least one live blood cell from the sample. The method further comprises generating one or more multispectral or hyperspectral images of the at least one cell, and analysing spectral characteristics of autofluorescence from the at least one cell. Also disclosed is a system configured to aid in the detection or diagnosis of a neurodegenerative disease. Also disclosed is a method for selecting a subject for treatment for a neurodegenerative disease. Also disclosed is a method for monitoring the response of a subject to a therapeutic treatment for a neurodegenerative disease. Also disclosed is a protocol for monitoring the efficacy of a therapeutic treatment for a neurodegenerative disease.
COMMONWEALTH OF AUSTRALIA, REPRESENTED BY DEPARTMENT OF DEFENCE, DEFENCE SCIENCE AND TECHNOLOGY ORGANISATION (Australie)
Inventeur(s)
Downes, James
Kitzler, Ondra
Pask, Helen, Margaret
Spence, David, James
Abrégé
Described herein is a LiDAR system for measuring characteristics of an aquatic environment. The system comprises a transmitter module comprising a diode laser source configured to emit pulses of light and direct the pulses of light towards a measuring zone in the aquatic environment. A portion of the emitted pulses of light is returned from the measuring zone as returned light. A receiver module comprises one or more detectors and is configured to receive a portion of the returned light and generate a plurality of detector signals. Each detector signal represents the intensity of the portion of the returned light at a pre-determined wavelength. A processor module is configured to determine a distance between the system and a position at which the emitted pulses of light are returned based, at least in part, on time-of-flight, and determine one or more characteristics of the measuring zone.
G01N 21/84 - Systèmes spécialement adaptés à des applications particulières
G01S 7/481 - Caractéristiques de structure, p. ex. agencements d'éléments optiques
G01S 15/00 - Systèmes utilisant la réflexion ou la reradiation d'ondes acoustiques, p. ex. systèmes sonar
G01S 17/10 - Systèmes déterminant les données relatives à la position d'une cible pour mesurer la distance uniquement utilisant la transmission d'ondes à modulation d'impulsion interrompues
G01S 17/89 - Systèmes lidar, spécialement adaptés pour des applications spécifiques pour la cartographie ou l'imagerie
The present disclosure relates to the generation of functionalised matrices comprising self- aggregating protein particles absorbed, combined or bound to the porous matrix. More particularly, the disclosure relates to matrices comprising p40 containing protein nanoparticles which modified matrices exhibit functional activity.
C12N 11/02 - Enzymes ou cellules microbiennes immobilisées sur ou dans un support organique
B01D 15/38 - Adsorption sélective, p. ex. chromatographie caractérisée par le mécanisme de séparation impliquant une interaction spécifique non couverte par un ou plusieurs des groupes , p. ex. chromatographie d'affinité, chromatographie d'échange par ligand ou chromatographie chirale
B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques
C12N 9/02 - Oxydoréductases (1.), p. ex. luciférase
C12N 11/08 - Enzymes ou cellules microbiennes immobilisées sur ou dans un support organique le support étant un polymère synthétique
C12N 11/082 - Enzymes ou cellules microbiennes immobilisées sur ou dans un support organique le support étant un polymère synthétique obtenu par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone
C12N 11/10 - Enzymes ou cellules microbiennes immobilisées sur ou dans un support organique le support étant un hydrate de carbone
A brushless DC motor comprising a rotor including circumferentially spaced permanent magnets, a first stator including a number of first poles having respective first windings, a second stator including a number of second poles having respective second windings and a controller configured to control application of drive currents to the first and second windings to thereby apply a torque to the rotor to cause rotation of the rotor, wherein the first and second stators are configured to provide a phase offset so that drive currents are applied to at least some of the second windings when switching application of drive currents between the first windings to thereby maintain torque on the rotor.
H02P 6/10 - Dispositions pour commander l'ondulation du couple, p. ex. en assurant une ondulation réduite du couple
H02K 3/46 - Fixation des enroulements sur la structure statorique ou rotorique
H02K 21/02 - Moteurs synchrones à aimants permanentsGénératrices synchrones à aimants permanents Détails
H02K 21/12 - Moteurs synchrones à aimants permanentsGénératrices synchrones à aimants permanents avec des induits fixes et des aimants tournants
H02P 7/06 - Dispositions pour réguler ou commander la vitesse ou le couple de moteurs électriques à courant continu pour réguler ou commander individuellement un moteur dynamo-électrique à courant continu en faisant varier le champ ou le courant d'induit
H02P 7/29 - Dispositions pour réguler ou commander la vitesse ou le couple de moteurs électriques à courant continu pour réguler ou commander individuellement un moteur dynamo-électrique à courant continu en faisant varier le champ ou le courant d'induit par commande maîtresse avec puissance auxiliaire utilisant des tubes à décharge ou des dispositifs à semi-conducteurs utilisant des dispositifs à semi-conducteurs commandant l'alimentation de l'induit seulement utilisant la modulation d'impulsions
H02P 7/293 - Dispositions pour réguler ou commander la vitesse ou le couple de moteurs électriques à courant continu pour réguler ou commander individuellement un moteur dynamo-électrique à courant continu en faisant varier le champ ou le courant d'induit par commande maîtresse avec puissance auxiliaire utilisant des tubes à décharge ou des dispositifs à semi-conducteurs utilisant des dispositifs à semi-conducteurs commandant l'alimentation de l'induit seulement utilisant des convertisseurs statiques, p. ex. de courant alternatif en courant continu en utilisant la commande de phase
1123452344 are any amino acid residue; and X5 is selected from V and I, provided that SEQ ID NO:2 is not KLSSIESDV. The invention further relates to fusion peptides thereof, methods of delivering an active agent across a cell membrane and/or across the blood brain barrier, and methods of treating or preventing a condition associated with neuronal hyperexcitation-associated neurotoxicity.
C07K 7/06 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 5 à 11 amino-acides
A61K 38/00 - Préparations médicinales contenant des peptides
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
C07K 14/00 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés
The present disclosure is directed to a surgical implant that allows for postoperative monitoring of said implant and an associated surgical site, such as a surgically-repaired joint, and methods of using same.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
A61B 17/58 - Instruments ou procédés chirurgicaux pour le traitement des os ou des articulationsDispositifs spécialement adaptés à cet effet pour ostéosynthèse, p. ex. plaques, vis ou matériels de fixation
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
The present invention relates to a particle analyser. In particular, the present invention relates to a device and a method for monitoring a dynamic profile of particles including deposition, and/or diffusion and/or dissolution rates of the particles.
The present invention relates to a device for aerosol characterisation. In particular, the present invention relates to a device and a method for providing dynamic measurement of an aerosol travelling in a mouth-throat model, a mouth-throat model comprising the device and an aerosol characterisation system comprising the device.
Disclosed are methods, systems and/or tags for digital polymerase chain reaction (PCR) assays. A method is provided for a lifetime-multiplex digital polymerase chain reaction assay, comprising forming a combined mixture of a reaction mixture and a sample that potentially contains two or more target nucleic acids, the reaction mixture including acceptor-tags each with an acceptor attached, and conjugated donor-tags each with a donor attached. A first target nucleic acid and a second target nucleic acid are subjected to polymerase chain reaction amplification. First acceptor-tags hybridize with the conjugated donor-tags when the first target nucleic acid is present. Second acceptor-tags hybridize with the conjugated donor-tags when the second target nucleic acid is present. A first lifetime is measured of luminescence of the acceptors of the first acceptor-tags. A second lifetime is measured of luminescence of the acceptors of the second acceptor-tags. The first lifetime is different to the second lifetime.
C12Q 1/686 - Réaction en chaine par polymérase [PCR]
C12Q 1/6818 - Tests d’hybridation caractérisés par les moyens de détection impliquant l’interaction de plusieurs marqueurs, p. ex. transfert d’énergie de résonance
There is provided a transgenic insect comprising a heterologous nucleic acid encoding a bacterial α-amylase, wherein the heterologous nucleic acid is integrated in the insect genome, wherein the heterologous nucleic acid is operably linked to a promoter, and expression of the α-amylase allows for the production of an active bacterial α-amylase in the insect. The insect or α-amylase preparation made from the insect is used for animal feed or feed additives and other industrial applications.
There is provided a transgenic insect comprising a heterologous nucleic acid encoding a fungal xylanase, wherein the heterologous nucleic acid is integrated in the insect genome, wherein the heterologous nucleic acid is operably linked to a promoter, and expression of the xylanase allows for the production of an active fungal xylanase in the insect. The insect or xylanase preparation made from the insect is used for animal feed or feed additives and other industrial applications.
The present disclosure relates to genetically modified insects or arachnids whose genome comprises at least one exogenous nucleic acid sequence that encodes a peptide or polypeptide that disrupts ion channel function as well as uses of the insects or arachnids for effecting reduction in the population of mated females.
C07K 14/435 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
13.
Delaminating and laminating of photovoltaic modules and solar cells using microwaves
A method of delaminating a photovoltaic module is disclosed wherein the photovoltaic module comprises at least one solar cell having a first surface and a second surface opposite to the first surface, a first protective sheet, and a first encapsulant material positioned between the first surface of the at least one solar cell and the first protective sheet and fixing the first protective sheet to the at least one solar cell, the method comprising applying microwave radiation to the at least one solar cell to heat the at least one solar cell to a temperature above a melting or softening temperature of the first encapsulant material, wherein heat is transferred from the at least one solar cell to the first encapsulant material. A method of manufacturing a photovoltaic module is also disclosed that comprises applying microwave radiation to at least one solar cell.
An object transfer system configured to transfer an object between autonomous aerial vehicles. The system includes an object transfer mechanism configured to transfer an object between the vehicles, a pose detection system configured to detect a relative pose of the vehicles and one or more processing devices configured to use the pose detection system to determine a relative pose of the vehicles, control at least one of the vehicles in accordance with the determined relative pose so that the vehicles have a target relative pose and operate the object transfer mechanism to thereby transfer the object between the vehicles.
B64U 101/64 - Véhicules aériens sans pilote spécialement adaptés à des utilisations ou à des applications spécifiques au transport de passagersVéhicules aériens sans pilote spécialement adaptés à des utilisations ou à des applications spécifiques au transport de marchandises autres que des armes à la livraison ou au retrait de colis
G05D 1/243 - Moyens de capture de signaux provenant naturellement de l’environnement, p. ex. signaux optiques, acoustiques, gravitationnels ou magnétiques ambiants
G05D 1/244 - Dispositions pour déterminer la position ou l’orientation utilisant des aides à la navigation passive extérieures au véhicule, p. ex. marqueurs, réflecteurs ou moyens magnétiques
G05D 1/656 - Interaction avec des charges utiles ou des entités externes
G05D 1/667 - Livraison ou récupération de charges utiles
G05D 1/689 - Interaction avec des charges utiles ou des entités externes dirigeant des charges utiles vers des cibles fixes ou en mouvement
G05D 1/69 - Commande coordonnée de la position ou du cap de plusieurs véhicules
G05D 1/697 - Commande coordonnée de la position ou du cap de plusieurs véhicules pour la rencontre de plusieurs véhicules, p. ex. pour le ravitaillement en vol
A facial expression sensing method including acquiring radar data from a radar sensor configured to perform range sensing in an environment including a person, analysing the radar data to determine facial radar data indicative of radar data captured from a face of the person, determining a facial expression by using facial radar data and at least one computational model, the at least one computational model being at least partially indicative of relationships between facial radar data and different facial expressions and generating an indication of the facial expression.
G06V 40/16 - Visages humains, p. ex. parties du visage, croquis ou expressions
G01S 7/41 - Détails des systèmes correspondant aux groupes , , de systèmes selon le groupe utilisant l'analyse du signal d'écho pour la caractérisation de la cibleSignature de cibleSurface équivalente de cible
G01S 13/06 - Systèmes déterminant les données relatives à la position d'une cible
G01S 13/86 - Combinaisons de systèmes radar avec des systèmes autres que radar, p. ex. sonar, chercheur de direction
G01S 13/87 - Combinaisons de plusieurs systèmes radar, p. ex. d'un radar primaire et d'un radar secondaire
G01S 13/88 - Radar ou systèmes analogues, spécialement adaptés pour des applications spécifiques
G01S 13/90 - Radar ou systèmes analogues, spécialement adaptés pour des applications spécifiques pour la cartographie ou la représentation utilisant des techniques d'antenne synthétique
G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
G06V 40/10 - Corps d’êtres humains ou d’animaux, p. ex. occupants de véhicules automobiles ou piétonsParties du corps, p. ex. mains
The present disclosure relates generally to methods for modulating the expression of a heterologous transgene administered to a cell, and to nucleic acid constructs useful in such methods. The present disclosure also relates to the use of the nucleic acid constructs for enhancing motor neuron survival, inhibiting motor neuron degeneration and treating neurodegenerative conditions.
C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
C12Q 1/6897 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques faisant intervenir des gènes rapporteurs liés de façon fonctionnelle à des promoteurs
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
A payload system for carrying a payload including a platform configured to support the payload, and a payload distribution sensor configured to sense the distribution of the payload on the platform. At least two autonomous aerial vehicles are provided, with coupling arrangements being configured to couple each vehicle to the platform. One or more processing devices configured to determine a payload distribution in accordance with signals from the payload distribution sensor and control operation of the vehicles in accordance with the determined payload distribution to thereby allow the platform and payload to be lifted.
B64U 101/60 - Véhicules aériens sans pilote spécialement adaptés à des utilisations ou à des applications spécifiques au transport de passagersVéhicules aériens sans pilote spécialement adaptés à des utilisations ou à des applications spécifiques au transport de marchandises autres que des armes
G05D 1/646 - Suivi d’une trajectoire prédéfinie, p. ex. d’une ligne marquée sur le sol ou d’une trajectoire de vol
G05D 1/695 - Commande coordonnée de la position ou du cap de plusieurs véhicules pour maintenir la position des véhicules les uns par rapport aux autres, p. ex. pour les voyages en convoi ou les vols en formation
Described is a method comprising receiving a rerouted phone call identified as a scam call, processing received caller speech from the rerouted phone call to determine a response, interacting with a caller using the determined response, and processing at least a part of the call conversation to determine one or more scam parameters. The response is determined in order to extend a duration of a conversation. The scam parameters may include one or more of the following: a scam target, a scam structure, a scam technique, a financial instrument, scammer phone number, scammer voice prints, classification of background noise during scam and/or a scam classification. The processing may further comprise identifying features in the received call speech associated with ending and/or extending a call.
G06Q 40/06 - Gestion de biensPlanification ou analyse financières
G06Q 50/50 - Procédés d’affaires s’appliquant à l’industrie des télécommunications
G10L 13/027 - Synthétiseurs de parole à partir de conceptsGénération de phrases naturelles à partir de concepts automatisés
G10L 15/26 - Systèmes de synthèse de texte à partir de la parole
G10L 17/26 - Reconnaissance de caractéristiques spéciales de voix, p. ex. pour utilisation dans les détecteurs de mensongeReconnaissance des voix d’animaux
H04L 51/02 - Messagerie d'utilisateur à utilisateur dans des réseaux à commutation de paquets, transmise selon des protocoles de stockage et de retransmission ou en temps réel, p. ex. courriel en utilisant des réactions automatiques ou la délégation par l’utilisateur, p. ex. des réponses automatiques ou des messages générés par un agent conversationnel
H04L 51/212 - Surveillance ou traitement des messages utilisant un filtrage ou un blocage sélectif
H04L 65/1076 - Passage au crible des communications IP en temps réel, p. ex. pourriel sur la téléphonie Internet [SPIT]
H04L 65/1104 - Protocole d'initiation de session [SIP]
H04M 3/42 - Systèmes fournissant des fonctions ou des services particuliers aux abonnés
H04M 3/436 - Dispositions pour intercepter des appels entrants
H04M 3/54 - Dispositions pour dériver des appels d'un abonné à un autre abonné déterminé
H04M 7/00 - Dispositions d'interconnexion entre centres de commutation
The present disclosure relates to a surf craft comprising one or more illuminated regions on an underside of the surf craft, the underside defining a surface that faces a body of water in use. The disclosure also relates to a method of reducing interactions with sharks, the method comprising arranging one or more illuminated portions on an underside of a surf craft, the underside defining a surface that faces a body of water in use, and a system for reducing interaction of sharks with a surf craft, the system comprising arranging one or more lights on at least a portion of downward facing surfaces of the surf craft, the one or lights being arranged such that the surf craft is counter-illuminated.
A01M 29/10 - Épouvantails ou dispositifs répulsifs, p. ex. pour oiseaux utilisant des moyens visuels, p. ex. épouvantails, éléments en mouvement, formes spécifiques, motifs ou éléments similaires spécifiques utilisant des sources lumineuses, p. ex. des lasers ou des lumières clignotantes
B63B 32/40 - Planches nautiques de type “twintip”Planches nautiques de type “wakeboard”Planches de surf Planches à voilePlanches à pagaie, p. ex. planches SUPAccessoires spécialement adaptés à cet effet
B63B 45/02 - Aménagements ou adaptations de dispositifs de signalisation ou d'éclairage les appareils étant prévus pour éclairer la route ou d'autres zones environnantes
Described herein is a Brillouin laser system (100, 150, 200, 300, 400) including a pump laser (102) configured to generate an input pump beam (104) having a pump frequency. A cavity resonator (106) is configured to receive the input pump beam (104). A Brillouin gain medium (112) is disposed within the cavity resonator (106) and configured to stimulate Brillouin scattering of the input pump beam (104) to generate one or more frequency shifted output modes (114) which oscillate within the cavity resonator (106). An output mirror (110) is configured for coupling the one or more frequency shifted output modes (114) from the cavity resonator (106). The cavity resonator (106) is designed to have a Q factor that is lower for the pump frequency than for the frequencies of the one or more frequency shifted output modes (114).
H01S 3/108 - Commande de l'intensité, de la fréquence, de la phase, de la polarisation ou de la direction du rayonnement, p. ex. commutation, ouverture de porte, modulation ou démodulation par commande de dispositifs placés dans la cavité utilisant des dispositifs optiques non linéaires, p. ex. produisant une diffusion par effet Brillouin ou Raman
H01S 3/0805 - Modes transversaux ou latéraux à l'aide d'ouvertures, p. ex. de trous d'épingle ou de couteaux
H01S 3/081 - Structure ou forme des résonateurs optiques ou de leurs composants comprenant trois réflecteurs ou plus
H01S 3/094 - Procédés ou appareils pour l'excitation, p. ex. pompage utilisant le pompage optique par de la lumière cohérente
H01S 3/106 - Commande de l'intensité, de la fréquence, de la phase, de la polarisation ou de la direction du rayonnement, p. ex. commutation, ouverture de porte, modulation ou démodulation par commande de dispositifs placés dans la cavité
A process is described for forming a nanostructured metal oxide micro-cluster. The process comprises the steps of obtaining a thin film of metal oxide attached to an underlying surface. The thin film has a peripheral edge. A droplet of volatile solvent is added adjacent to the peripheral edge of the thin film. The droplet of volatile solvent wets the thin film of metal oxide and subsequently evaporates, thereby allowing capillary force induced self-assembly to change the thin film structure.
H10K 30/35 - Dispositifs organiques sensibles au rayonnement infrarouge, à la lumière, au rayonnement électromagnétique de plus courte longueur d'onde ou au rayonnement corpusculaire comprenant des hétérojonctions de masse, p. ex. des réseaux interpénétrés de domaines de matériaux donneurs et accepteurs comprenant des nanostructures inorganiques, p. ex. des nanoparticules de CdSe
B82Y 20/00 - Nano-optique, p. ex. optique quantique ou cristaux photoniques
C01G 9/03 - Procédés d'obtention par voie sèche, p. ex. procédés en phase vapeur
H01L 31/02 - Dispositifs à semi-conducteurs sensibles aux rayons infrarouges, à la lumière, au rayonnement électromagnétique d'ondes plus courtes, ou au rayonnement corpusculaire, et spécialement adaptés, soit comme convertisseurs de l'énergie dudit rayonnement e; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de ces dispositifs ou de leurs parties constitutives; Leurs détails - Détails
A nasal delivery testing device is disclosed comprising one or more nasal cast components with an impression of at least part of a nasal cavity, which is part of an airflow path between an airflow entrance and an airflow exit. The nasal delivery device may form part of a nasal delivery testing system that also includes an air pump connectable to the airflow exit, the air pump configured to provide air suction at the airflow exit. There is also disclosed a nasal delivery testing system including at least one sensor for one or more therapeutic agents, airborne pathogens or pollutants. Also disclosed is a method for testing nasal delivery of an agent.
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
UNIVERSITÉ DE STRASBOURG (France)
MACQUARIE UNIVERSITY (Australie)
Inventeur(s)
Pupillo, Guido
Jandura, Sven
Brennen, Gavin
Srivastava, Vineesha
Abrégé
The present invention concerns a device (10) adapted to implement a deterministic quantum gate, the device (10) comprising : - a trap (14) having an excitation mode, the trap (14) being adapted to trap a plurality of quantum objects (12) coupled with the excitation mode of the trap (14), each quantum object (12) comprising three eigenstates, respectively named a 0 state, a 1 state and a e state, and the quantum objects (12) being in all-to-all coupling configuration, and - a trap driver (16), the trap driver (16) being a wave generator adapted to generate a driving wave driving the excitation mode to which the plurality of quantum objects (12) are coupled, said wave having a frequency and an amplitude shaped to apply a deterministic non-local quantum gate on said quantum objects (12).
G06N 10/40 - Réalisations ou architectures physiques de processeurs ou de composants quantiques pour la manipulation de qubits, p. ex. couplage ou commande de qubit
G06N 10/20 - Modèles d’informatique quantique, p. ex. circuits quantiques ou ordinateurs quantiques universels
G06N 10/70 - Correction, détection ou prévention d’erreur quantique, p. ex. codes de surface ou distillation d’état magique
Provided herein are modified cyclin F polypeptides and nucleic acid molecules encoding the same. In particular, provided herein are modified cyclin F polypeptides that have increased cytoplasmic targeting compared to wild-type cyclin F polypeptides, and functional, truncated modified cyclin F polypeptides, and nucleic acid molecules encoding the same. Also provided herein is the use of the modified cyclin F polypeptides and encoding nucleic acid molecules for enhancing motor neuron survival, inhibiting motor neuron degeneration and treating neurodegenerative conditions, in particular those associated with neuronal TDP-43 proteinopathy.
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
There is provided a transgenic insect comprising a heterologous nucleic acid encoding a bacterial phytase, wherein the heterologous nucleic acid is integrated in the insect genome, wherein the heterologous nucleic acid is operably linked to a promoter, and expression of the phytase allows for the production of an active bacterial phytase in the insect. The insect or phytase preparation made from the insect are used for feed additives and phosphorus waste management.
A23K 50/30 - Produits alimentaires spécialement conçus pour des animaux spécifiques pour les porcs
A23K 50/75 - Produits alimentaires spécialement conçus pour des animaux spécifiques pour les oiseaux pour la volaille
A23K 50/80 - Produits alimentaires spécialement conçus pour des animaux spécifiques pour les animaux aquatiques, p. ex. pour les poissons, les crustacés ou les mollusques
C12N 9/16 - Hydrolases (3.) agissant sur les liaisons esters (3.1)
C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales
The present disclosure relates to a mutant neuroserpin protein or portion thereof, to a nucleic acid comprising nucleotide sequence which encodes a mutant neuroserpin protein or portion thereof, and to use of the nucleic acid or mutant neuroserpin protein or portion thereof for treating glaucoma and other disorders associated with elevated plasmin activity.
Disclosed are compounds of Formula I and their use as inhibitors of the viral protease non-structural protein 5 (NSP5). Typically, the NSP5 is derived from a coronavirus, more typically from SARS-CoV-2. More particularly, the invention relates to compounds of Formula (I) and their use for treating or inhibiting the development of a condition in which inhibiting NSP5 activity is associated with effective treatment or inhibition, including a coronavirus infection, for treating or inhibiting the development of a condition associated with a coronavirus infection, for treating or inhibiting the development of neurological symptoms of, and/or neurological complications associated with, a coronavirus infection and for treating or inhibiting the development or progression of long COVID following SARS-CoV-2 infection.
C07D 401/14 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant au moins trois hétérocycles
A61K 31/4545 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pipampérone, anabasine
A61K 31/517 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des systèmes carbocycliques, p. ex. quinazoline, périmidine
A61P 31/14 - Antiviraux pour le traitement des virus ARN
C07D 409/14 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre comme uniques hétéro-atomes du cycle contenant au moins trois hétérocycles
The invention relates to methods and compositions comprising the use of Vascular Endothelial Growth Factor inhibitors in the treatment or prevention of joint disorders characterised by hypervascularity, inflammation and/or fibrosis of the joint capsule.
C07K 16/22 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des facteurs de croissance
A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
A61P 19/02 - Médicaments pour le traitement des troubles du squelette des troubles articulaires, p. ex. arthrites, arthroses
A method comprises receiving a rerouted phone call identified as a scam call, and processing received caller speech from the rerouted phone call to determine a response. The method includes interacting with a caller using the determined response, wherein the response is determined in order to extend a duration of the phone call. The processing may comprise identifying features in the received call speech associated with ending and/or extending a call. The identifying may comprise identifying one or more of: negative emotions in the caller speech, and threats in the caller speech.
G10L 13/027 - Synthétiseurs de parole à partir de conceptsGénération de phrases naturelles à partir de concepts automatisés
G10L 15/26 - Systèmes de synthèse de texte à partir de la parole
G10L 25/30 - Techniques d'analyse de la parole ou de la voix qui ne se limitent pas à un seul des groupes caractérisées par la technique d’analyse utilisant des réseaux neuronaux
H04L 65/1076 - Passage au crible des communications IP en temps réel, p. ex. pourriel sur la téléphonie Internet [SPIT]
H04M 3/436 - Dispositions pour intercepter des appels entrants
The technology relates to the use of 1-octanol, 1-nonanol, a combination thereof or compositions comprising either or both of 1-octanol and 1-nonanol for modifying the behaviour of tephritid fruit flies. In particular the 1-octanol, 1-nonanol or compositions described herein can be used to repel and/or modulate the feeding, mating or oviposition behaviour of tephritid fruit flies such as the Queensland fruit fly and the Mediterranean fruit fly.
There is provided a transgenic animal comprising heterologous nucleic acid encoding a bacterial organomercurial lyase and/or a bacterial mercuric reductase, wherein the transgenic animal expresses the bacterial organomercurial lyase and/or a bacterial mercuric reductase to reduce the toxicity of a mercury compound.
A01K 67/033 - NÉCESSITÉS COURANTES DE LA VIE ÉLEVAGE; CHASSE; PIÉGEAGE; PÊCHE ÉLEVAGE; AVICULTURE; APICULTURE; PISCICULTURE; PÊCHE; OBTENTION D'ANIMAUX, NON PRÉVUE AILLEURS; NOUVELLES RACES D'ANIMAUX Élevage ou obtention d'animaux, non prévus ailleurs; Nouvelles races d'animaux Élevage ou obtention d'invertébrés; Nouvelles races d'invertébrés
A62D 3/02 - Procédés pour rendre les substances chimiques nuisibles inoffensives ou moins nuisibles en effectuant un changement chimique dans les substances par des procédés biologiques, c.-à-d. des procédés utilisant des enzymes ou des micro-organismes
A62D 101/43 - Substances inorganiques contenant des métaux lourds à l'état lié ou libre
B09B 3/60 - Traitement biochimique, p. ex. en utilisant des enzymes
C12N 9/02 - Oxydoréductases (1.), p. ex. luciférase
An aluminosilicate glass having a composition according to the following formula (I):
An aluminosilicate glass having a composition according to the following formula (I):
(100−(1+a1+b1)·x)SiO2·(x)Al2O3·(a1·x)MO·(b1·x)R (wt %) (I)
An aluminosilicate glass having a composition according to the following formula (I):
(100−(1+a1+b1)·x)SiO2·(x)Al2O3·(a1·x)MO·(b1·x)R (wt %) (I)
in which MO is alkaline earth metal oxide, the alkaline earth metal M being one or more of Mg, Ca, Sr, and Ba, R comprises alkali metal oxide, the alkali metal being one or more of Li, Na, and K, x is at least 15, a1 is at least 0.35, b1 is at least 0.55, and wherein the product of a1 and b1 is at least 0.22.
C03C 3/091 - Compositions pour la fabrication du verre contenant de la silice avec 40 à 90% en poids de silice contenant du bore contenant de l'aluminium
C03C 3/087 - Compositions pour la fabrication du verre contenant de la silice avec 40 à 90% en poids de silice contenant de l'oxyde d'aluminium ou un composé du fer contenant un oxyde d'un métal divalent contenant de l'oxyde de calcium, p. ex. verre à vitre ordinaire ou verre pour récipients creux
G02B 6/13 - Circuits optiques intégrés caractérisés par le procédé de fabrication
C03C 23/00 - Autres traitements de surface du verre, autre que sous forme de fibres ou de filaments
33.
DELAMINATING AND LAMINATING OF PHOTOVOLTAIC MODULES AND SOLAR CELLS USING MICROWAVES
A method of delaminating a photovoltaic module is disclosed wherein the photovoltaic module comprises at least one solar cell having a first surface and a second surface opposite to the first surface, a first protective sheet, and a first encapsulant material positioned between the first surface of the at least one solar cell and the first protective sheet and fixing the first protective sheet to the at least one solar cell, the method comprising applying microwave radiation to the at least one solar cell to heat the at least one solar cell to a temperature above a melting or softening temperature of the first encapsulant material, wherein heat is transferred from the at least one solar cell to the first encapsulant material. A method of manufacturing a photovoltaic module is also disclosed that comprises applying microwave radiation to at least one solar cell.
H05B 6/80 - Appareils pour applications spécifiques
B29B 17/02 - Séparation de matières plastiques des autres matières
B29C 51/14 - Façonnage par thermoformage, p. ex. façonnage de feuilles dans des moules en deux parties ou par emboutissage profondAppareils à cet effet de préformes ou de feuilles multicouches
B32B 37/06 - Procédés ou dispositifs pour la stratification, p. ex. par polymérisation ou par liaison à l'aide d'ultrasons caractérisés par le procédé de chauffage
B32B 43/00 - Opérations spécialement adaptées aux produits stratifiés et non prévues ailleurs, p. ex. réparationAppareils pour ces opérations
Methods and systems configured to assist with generating, controlling and detecting multiple orbital angular momentum (OAM) modes are described. An optical device for OAM multiplexing and/or demultiplexing (100), includes a metasurface (206B) for at least one of generating and receiving a plurality of OAM modes and one or more single-mode waveguides (110-1, 110-2, 110-3, …, 110-M) for coupling with a light source (102) or receiver (108) or a microwave or millimetre wave source or receiver. The metasurface spatially matches one or more of the plurality of OAM modes to a corresponding one or more of the single-mode waveguides.
G02B 1/00 - Éléments optiques caractérisés par la substance dont ils sont faitsRevêtements optiques pour éléments optiques
G02B 6/10 - Guides de lumièreDétails de structure de dispositions comprenant des guides de lumière et d'autres éléments optiques, p. ex. des moyens de couplage du type guide d'ondes optiques
G02B 6/12 - Guides de lumièreDétails de structure de dispositions comprenant des guides de lumière et d'autres éléments optiques, p. ex. des moyens de couplage du type guide d'ondes optiques du genre à circuit intégré
Provided herein are methods for enhancing survival of a neuron, for inhibiting degeneration of a neuron, and for inhibiting abnormal protein accumulation in a neuron, optionally a motor neuron, comprising, consisting or consisting essentially of increasing the level of cyclin F in the neuron regardless of the neuron's level or activity of endogenous cyclin F. Optionally the neuron is in a subject with a neurodegenerative condition or at risk of developing a neurodegenerative condition, typically a neurodegenerative condition associated with a neuronal TDP-43 proteinopathy.
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
The present disclosure is directed to a surgical implant that allows for postoperative monitoring of said implant and an associated surgical site, such as a surgically-repaired joint, and methods of using same.
Disclosed is a method for diagnosing a neurodegenerative disease in a subject. The method comprises obtaining from the subject a sample comprising at least one live blood cell, and optionally isolating at least one live blood cell from the sample. The method further comprises generating one or more multispectral or hyperspectral images of the at least one cell, and analysing spectral characteristics of autofluorescence from the at least one cell. Also disclosed is a system configured to aid in the detection or diagnosis of a neurodegenerative disease. Also disclosed is a method for selecting a subject for treatment for a neurodegenerative disease. Also disclosed is a method for monitoring the response of a subject to a therapeutic treatment for a neurodegenerative disease. Also disclosed is a protocol for monitoring the efficacy of a therapeutic treatment for a neurodegenerative disease.
Provided herein are modified cyclin F polypeptides and nucleic acid molecules encoding the same. In particular, provided herein are modified cyclin F polypeptides that have increased cytoplasmic targeting compared to wild-type cyclin F polypeptides, and functional, truncated modified cyclin F polypeptides, and nucleic acid molecules encoding the same. Also provided herein is the use of the modified cyclin F polypeptides and encoding nucleic acid molecules for enhancing motor neuron survival, inhibiting motor neuron degeneration and treating neurodegenerative conditions, in particular those associated with neuronal TDP-43 proteinopathy.
A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
C12N 15/12 - Gènes codant pour des protéines animales
Provided herein are modified cyclin F polypeptides and nucleic acid molecules encoding the same. In particular, provided herein are modified cyclin F polypeptides that have increased cytoplasmic targeting compared to wild-type cyclin F polypeptides, and functional, truncated modified cyclin F polypeptides, and nucleic acid molecules encoding the same. Also provided herein is the use of the modified cyclin F polypeptides and encoding nucleic acid molecules for enhancing motor neuron survival, inhibiting motor neuron degeneration and treating neurodegenerative conditions, in particular those associated with neuronal TDP-43 proteinopathy.
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
Provided herein are methods for treating, delaying the onset of, or ameliorating at least one symptom of, dementia associated with #-amyloid (A#) accumulation, and for improving memory in subjects suffering from dementia associated with A# accumulation, comprising administering to subjects in need thereof an effective amount of an inhibitor of LIMK1, wherein the inhibitor comprises a compound of Formula (I) as defined herein, or a pharmaceutically acceptable salt thereof. Also provided are methods for reducing A# toxicity in neurons, comprising exposing neurons to an effective amount of an inhibitor of LIMK1, wherein the inhibitor comprises a compound of Formula (I) as defined herein, or a pharmaceutically acceptable salt thereof.
A61K 31/519 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
Disclosed herein are methods for treating or preventing an excitotoxicity-related condition, optionally a condition associated with seizures and/or resulting from or associated with a cerebral ischemic event, comprising administering to a subject in need an effective amount of an inhibitor of Lim-domain kinase 1 (LIMK1). Also provided are methods for treating or preventing seizures and for reducing excitotoxicity in neurons and/or protecting neurons from excitotoxicity.
A semiconductor transistor device operable as a RF mixer is described. The device includes a field effect transistor with a field plate electrode. The field plate electrode is structured and located to be electromagnetically coupled to the gate electrode of the field effect transistor when carrying a radio frequency oscillation signal, to cause the field effect transistor to produce an output signal that is a mixed signal at the gate and the field plate. A semiconductor device for a radio receiver is also described. The device includes a field effect transistor with a field plate. A transient voltage signal is applied to the field plate responsive to detection of an interfering signal.
H01L 29/08 - Corps semi-conducteurs caractérisés par les formes, les dimensions relatives, ou les dispositions des régions semi-conductrices avec des régions semi-conductrices connectées à une électrode transportant le courant à redresser, amplifier ou commuter, cette électrode faisant partie d'un dispositif à semi-conducteur qui comporte trois électrodes ou plus
H01L 29/417 - Electrodes caractérisées par leur forme, leurs dimensions relatives ou leur disposition relative transportant le courant à redresser, à amplifier ou à commuter
H01L 29/423 - Electrodes caractérisées par leur forme, leurs dimensions relatives ou leur disposition relative ne transportant pas le courant à redresser, à amplifier ou à commuter
H03K 17/041 - Modifications pour accélérer la commutation sans réaction du circuit de sortie vers le circuit de commande
H03K 17/0812 - Modifications pour protéger le circuit de commutation contre la surintensité ou la surtension sans réaction du circuit de sortie vers le circuit de commande par des dispositions prises dans le circuit de commande
H03K 17/687 - Commutation ou ouverture de porte électronique, c.-à-d. par d'autres moyens que la fermeture et l'ouverture de contacts caractérisée par l'utilisation de composants spécifiés par l'utilisation, comme éléments actifs, de dispositifs à semi-conducteurs les dispositifs étant des transistors à effet de champ
H03K 17/16 - Modifications pour éliminer les tensions ou courants parasites
H04B 1/403 - Circuits utilisant le même oscillateur pour générer à la fois la fréquence de l’émetteur et la fréquence de l’oscillateur local du récepteur
The present disclosure relates to a mutant neuroserpin protein or portion thereof, to a nucleic acid comprising nucleotide sequence which encodes a mutant neuroserpin protein or portion thereof, and to use of the nucleic acid or mutant neuroserpin protein or portion thereof for treating glaucoma and other disorders associated with elevated plasmin activity.
There is provided a transgenic insect comprising a heterologous nucleic acid encoding a fungal laccase wherein the heterologous nucleic acid is integrated in the insect genome, wherein the heterologous nucleic acid is operably linked to a promoter, and expression of the laccase allows for production of an active fungal laccase in the insect. The insect or laccase preparations comprising meal or powder made from the insect are used to reduce or remove phenolic contaminants (such as BPA) or aromatic components (such as indigo dyes) from waste.
A01K 67/033 - NÉCESSITÉS COURANTES DE LA VIE ÉLEVAGE; CHASSE; PIÉGEAGE; PÊCHE ÉLEVAGE; AVICULTURE; APICULTURE; PISCICULTURE; PÊCHE; OBTENTION D'ANIMAUX, NON PRÉVUE AILLEURS; NOUVELLES RACES D'ANIMAUX Élevage ou obtention d'animaux, non prévus ailleurs; Nouvelles races d'animaux Élevage ou obtention d'invertébrés; Nouvelles races d'invertébrés
A62D 3/02 - Procédés pour rendre les substances chimiques nuisibles inoffensives ou moins nuisibles en effectuant un changement chimique dans les substances par des procédés biologiques, c.-à-d. des procédés utilisant des enzymes ou des micro-organismes
C12N 9/02 - Oxydoréductases (1.), p. ex. luciférase
C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales
C12P 1/00 - Préparation de composés ou de compositions, non prévue dans les groupes , utilisant des micro-organismes ou des enzymesProcédés généraux de préparation de composés ou de compositions utilisant des micro-organismes ou des enzymes
Iterative methods for direction of arrival estimation of a signal at a receiver with a plurality of spatially separated sensor elements are described. A quantized estimate of the angle of arrival is obtained from a compressive sensing solution of a set of equations. The estimate is refined in a subsequent iteration by a computed error based a quantized estimate of the direction of arrival in relation to quantization points offset from the quantization points for the first quantized estimate of the angle of arrival. The iterations converge on an estimated direction of arrival.
G01S 3/04 - Radiogoniomètres pour déterminer la direction d'où proviennent des ondes infrasonores, sonores, ultrasonores ou électromagnétiques ou des émissions de particules sans caractéristiques de direction utilisant des ondes radio Détails
G01S 3/48 - Systèmes pour déterminer une direction ou une déviation par rapport à une direction prédéterminée en utilisant des antennes espacées et en mesurant la différence de phase ou de temps entre les signaux venant de ces antennes, c.-à-d. systèmes à différence de parcours les ondes arrivant aux antennes étant continues ou intermittentes et la différence de phase entre les signaux provenant de ces antennes étant mesurée
G01S 3/72 - Systèmes à diversité spécialement adaptés à la radiogoniométrie
G01S 3/80 - Radiogoniomètres pour déterminer la direction d'où proviennent des ondes infrasonores, sonores, ultrasonores ou électromagnétiques ou des émissions de particules sans caractéristiques de direction utilisant des ondes ultrasonores, sonores ou infrasonores
09 - Appareils et instruments scientifiques et électriques
16 - Papier, carton et produits en ces matières
35 - Publicité; Affaires commerciales
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Electronic publications (downloadable); electronic
publications including those sold and distributed online;
educational science apparatus and instruments; instructional
apparatus; instructional instruments; computer apparatus for
educational use; education software; pre-recorded dvds;
magnetic data carriers; pre-recorded compact discs (disks)
(cds); computer software programs; downloadable software
applications (apps). Printed matter; printed publications; posters; educational
materials in written form; books; publicity leaflets
(flyers); newspapers; newsletters; periodicals; photographs
(printed); stationery; teaching materials for education;
teaching materials for instruction; catalogues; brochures;
writing pens. Business administration; business management; business
networking services; office functions; marketing; publicity. Club education services; education services; educational
services; teaching; personal development courses; personal
development training; electronic publication of information
on a wide range of topics, including online and over a
global computer network; publication of educational
materials; publishing by electronic means; arranging and
conducting of colloquiums; arranging and conducting of
conferences; arranging and conducting of congresses;
arranging and conducting of seminars; arranging and
conducting of symposiums; arranging and conducting of
workshops (training); library services; arranging of
exhibitions for educational purposes; correspondence
courses; vocational guidance (education or training advice);
social club services (entertainment, sporting and cultural
services); training; keynote speaking; providing
international student exchange programmes [educational
services].
47.
Triboelectric energy harvesting with pipe-in-pipe structure
An apparatus includes an outer structure body having a cavity and an inner structure body rotatably supported within the cavity. The inner structure body has a central bore. Movable elements are positioned along the inner surface and movably coupled to the outer structure body. Ball elements are positioned along the outer surface and coupled to the inner structure body for movement with the inner structure body. The ball elements are positioned to releasably contact and impart motion to the movable elements in response to relative motion between the inner structure body and the outer structure body. A plurality of triboelectric energy harvesters are positioned to generate electrical charges when motion is imparted to the movable elements by the ball elements.
H02N 2/18 - Machines électriques en général utilisant l'effet piézo-électrique, l'électrostriction ou la magnétostriction fournissant une sortie électrique à partir d'une entrée mécanique, p. ex. générateurs
E21B 47/01 - Dispositifs pour supporter des instruments de mesure sur des trépans, des tubes, des tiges ou des câbles de forageProtection des instruments de mesure dans les trous de forage contre la chaleur, les chocs, la pression ou similaire
E21B 47/12 - Moyens pour la transmission de signaux de mesure ou signaux de commande du puits vers la surface, ou de la surface vers le puits, p. ex. pour la diagraphie pendant le forage
48.
System and method of distributed sensing in downhole drilling environments
A system includes sensing modules positioned along a length of a drill string. Each sensing module includes a structure arrangement composed of an outer structure body having a cavity and an inner structure body rotatably supported within the cavity. The structure arrangement is coupled to the drill string such that rotation of the drill string produces a relative rotation between the structure bodies. Ball elements are disposed in a gap between the structure bodies and move along a predetermined path defined in the gap in response to relative rotation between the structure bodies. Movable elements are positioned to physically interact with the ball elements as the ball elements move along the predetermined path. Energy harvesters in the sensor modules generate electrical energy from the mechanical energy produced by physical interaction between the ball elements and movable elements. The sensing modules include sensors to measure parameters in the drill string environment.
E21B 41/00 - Matériel ou accessoires non couverts par les groupes
E21B 47/26 - Stockage des données en fond de puits, p. ex. dans une mémoire ou sur un support d'enregistrement
E21B 47/00 - Relevés dans les trous de forage ou dans les puits
E21B 47/12 - Moyens pour la transmission de signaux de mesure ou signaux de commande du puits vers la surface, ou de la surface vers le puits, p. ex. pour la diagraphie pendant le forage
G01V 11/00 - Prospection ou détection par des méthodes combinant des techniques spécifiées dans les groupes
H01M 10/46 - Accumulateurs combinés par structure avec un appareil de charge
H02N 2/18 - Machines électriques en général utilisant l'effet piézo-électrique, l'électrostriction ou la magnétostriction fournissant une sortie électrique à partir d'une entrée mécanique, p. ex. générateurs
49.
PIEZOELECTRIC AND MAGNETOSTRICTIVE ENERGY HARVESTING WITH PIPE-IN-PIPE STRUCTURE
An apparatus includes an outer structure body (202) having an inner surface (216) defining a cavity (220) and an inner structure body (204) rotatably supported within the cavity. The inner structure body has an outer surface (248) in opposing relation to the inner surface (216) and a central bore. Movable elements (236) are positioned along the inner surface and movably coupled to the outer structure body. Ball elements (260) are positioned along the outer surface and coupled to the inner structure body for movement with the inner structure body. The ball elements (260) releasably contact the movable elements and impart motion to the movable elements in response to relative motion between the inner structure body and the outer structure body. Energy harvesters (632) are positioned to generate electrical charges based on piezoelectric effect or magnetostrictive effect when motion is imparted to the movable elements by the ball elements.
Self-powered active sensing systems (SASS) for use in downhole drilling environments are disclosed. Sensor devices of the SASS can include a self-powered rotational speed sensor including a ring structure attached around a drill string. The ring rotates within a groove formed in an outer housing. Bearings on the ring are arranged to contact moveable members extending from the housing into the groove thereby causing the moveable member to generate an electrical signal representing rotational speed. The SASS can include a vibration sensor having a ring spring mounted within a housing. Spherical bearings on the outer surface of the ring are configured to contact screens that are mounted to the housing and that generate a signal representing movement of the bearing/ring from vibration. Multiple SASS units configured to wirelessly transmit sensor data can be placed along a drill string providing a distributed self-powered system for measuring downhole parameters.
E21B 47/01 - Dispositifs pour supporter des instruments de mesure sur des trépans, des tubes, des tiges ou des câbles de forageProtection des instruments de mesure dans les trous de forage contre la chaleur, les chocs, la pression ou similaire
E21B 17/10 - Protecteurs contre l'usureDispositifs de centrage
E21B 47/017 - Protection des instruments de mesure
E21B 47/13 - Moyens pour la transmission de signaux de mesure ou signaux de commande du puits vers la surface, ou de la surface vers le puits, p. ex. pour la diagraphie pendant le forage par énergie électromagnétique, p. ex. gammes de fréquence radio
E21B 47/26 - Stockage des données en fond de puits, p. ex. dans une mémoire ou sur un support d'enregistrement
E21B 7/24 - Forage utilisant des moyens vibrants ou oscillants, p. ex. des masses déséquilibrées
E21B 41/00 - Matériel ou accessoires non couverts par les groupes
51.
Self-powered sensors for detecting downhole parameters
A self-powered sensor array (SPSA) for sensing environmental parameters along a drillstring includes an outer collar having moveable member retainers with moveable members movably located in the moveable member retainers. An inner ring is rotatably supported within the outer collar with bearing elements on an outer surface of the inner ring positioned to displace the moveable members relative to the moveable member retainers in response to relative rotation between the inner ring and the outer collar. Shape memory material elements are arranged in a respective moveable member retainer. Distance sensors are configured to sense a gap responsive to a shape change of the respective shape memory material element and a displacement of the respective moveable member. Power generation components are configured such that, in response to the relative rotation, the bearing elements displace a particular moveable member into a particular moveable member retainer, generating an electric charge.
E21B 41/00 - Matériel ou accessoires non couverts par les groupes
E21B 47/01 - Dispositifs pour supporter des instruments de mesure sur des trépans, des tubes, des tiges ou des câbles de forageProtection des instruments de mesure dans les trous de forage contre la chaleur, les chocs, la pression ou similaire
E21B 47/06 - Mesure de la température ou de la pression
E21B 47/085 - Mesure du diamètre ou des dimensions correspondantes des trous de forage utilisant des moyens de radiation, p. ex. des moyens acoustiques, radioactifs ou électromagnétiques
52.
Piezoelectric and magnetostrictive energy harvesting with pipe-in-pipe structure
An apparatus includes an outer structure body having an inner surface defining a cavity and an inner structure body rotatably supported within the cavity. The inner structure body has an outer surface in opposing relation to the inner surface and a central bore. Movable elements are positioned along the inner surface and movably coupled to the outer structure body. Ball elements are positioned along the outer surface and coupled to the inner structure body for movement with the inner structure body. The ball elements releasably contact the movable elements and impart motion to the movable elements in response to relative motion between the inner structure body and the outer structure body. Energy harvesters are positioned to generate electrical charges based on piezoelectric effect or magnetostrictive effect when motion is imparted to the movable elements by the ball elements.
H02N 2/18 - Machines électriques en général utilisant l'effet piézo-électrique, l'électrostriction ou la magnétostriction fournissant une sortie électrique à partir d'une entrée mécanique, p. ex. générateurs
E21B 17/00 - Tiges ou tubes de forageTrains de tiges souplesTiges d'entraînementMasses-tigesTiges de pompageTubagesColonnes de production
A self-powered sensor array (SPSA) for sensing environmental parameters along a drillstring includes an outer collar having moveable member retainers with moveable members movably located in the moveable member retainers. An inner ring is rotatably supported within the outer collar with bearing elements on an outer surface of the inner ring positioned to displace the moveable members relative to the moveable member retainers in response to relative rotation between the inner ring and the outer collar. Shape memory material elements are arranged in a respective moveable member retainer. Distance sensors are configured to sense a gap responsive to a shape change of the respective shape memory material element and a displacement of the respective moveable member. Power generation components are configured such that, in response to the relative rotation, the bearing elements displace a particular moveable member into a particular moveable member retainer, generating an electric charge.
E21B 47/01 - Dispositifs pour supporter des instruments de mesure sur des trépans, des tubes, des tiges ou des câbles de forageProtection des instruments de mesure dans les trous de forage contre la chaleur, les chocs, la pression ou similaire
E21B 47/06 - Mesure de la température ou de la pression
E21B 47/12 - Moyens pour la transmission de signaux de mesure ou signaux de commande du puits vers la surface, ou de la surface vers le puits, p. ex. pour la diagraphie pendant le forage
E21B 41/00 - Matériel ou accessoires non couverts par les groupes
54.
TRIBOELECTRIC ENERGY HARVESTING WITH PIPE-IN-PIPE STRUCTURE
An apparatus (400) includes an outer structure body (402) having an inner surface (416) defining a cavity (420) and an inner structure body (404) rotatably supported within the cavity (420). The inner structure body has an outer surface (448) in opposing relation to the inner surface and a central bore. Movable elements (434) are positioned along the inner surface and movably coupled to the outer structure body. Ball elements (460) are positioned along the outer surface and coupled to the inner structure body for movement with the inner structure body. The ball elements are positioned to releasably contact and impart motion to the movable elements in response to relative motion between the inner structure body and the outer structure body. A plurality of triboelectric energy harvesters (432) are positioned to generate electrical charges when motion is imparted to the movable elements by the ball elements.
A system includes sensing modules positioned along a length of a drill string. Each sensing module includes a structure arrangement composed of an outer structure body having a cavity and an inner structure body rotatably supported within the cavity. The structure arrangement is coupled to the drill string such that rotation of the drill string produces a relative rotation between the structure bodies. Ball elements are disposed in a gap between the structure bodies and move along a predetermined path defined in the gap in response to relative rotation between the structure bodies. Movable elements are positioned to physically interact with the ball elements as the ball elements move along the predetermined path. Energy harvesters in the sensor modules generate electrical energy from the mechanical energy produced by physical interaction between the ball elements and movable elements. The sensing modules include sensors to measure parameters in the drill string environment.
E21B 41/00 - Matériel ou accessoires non couverts par les groupes
H02N 2/18 - Machines électriques en général utilisant l'effet piézo-électrique, l'électrostriction ou la magnétostriction fournissant une sortie électrique à partir d'une entrée mécanique, p. ex. générateurs
An integrated circuit transformer is described that includes conductors in a bootstrap arrangement, providing an impedance transformation between a first port (P1) and a second port (P2). A path from a third port (P3) into the conductors is provided for a bias signal, the path including at least one via formation (54, 64) through a substrate of the integrated circuit to connect the third port (P3) with the conductor arrangement.
The technology relates to the use of 1-octanol, 1-nonanol, a combination thereof or compositions comprising either or both of 1-octanol and 1-nonanol for modifying the behaviour of tephritid fruit flies. In particular the 1-octanol, 1-nonanol or compositions described herein can be used to repel and/or modulate the feeding, mating or oviposition behaviour of tephritid fruit flies such as the Queensland fruit fly and the Mediterranean fruit fly.
The technology relates to the use of 1-octanol, 1-nonanol, a combination thereof or compositions comprising either or both of 1-octanol and 1-nonanol for modifying the behaviour of tephritid fruit flies. In particular the 1-octanol, 1-nonanol or compositions described herein can be used to repel and/or modulate the feeding, mating or oviposition behaviour of tephritid fruit flies such as the Queensland fruit fly and the Mediterranean fruit fly.
09 - Appareils et instruments scientifiques et électriques
16 - Papier, carton et produits en ces matières
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Downloadable electronic publications, namely, books, pamphlets, brochures, manuals, booklets, leaflets, informational flyers, informational sheets and newsletters in the field of post-secondary education; downloadable electronic publications, namely, books, pamphlets, brochures, manuals, booklets, leaflets, informational flyers, informational sheets and newsletters in the field of post-secondary education including those sold and distributed online; downloadable and recorded education software for use in the delivery, transmission and distribution of audio, video, text and multimedia content in the field of post-secondary education; pre-recorded dvds featuring information in the field of post-secondary education; pre-recorded magnetic data carriers featuring information in the field of post-secondary education; pre-recorded compact discs featuring information in the field of post-secondary education; downloadable and recorded computer software programs for use in the delivery, transmission and distribution of audio, video, text and multimedia content in the field of post-secondary education; downloadable software applications for use in the delivery, transmission and distribution of audio, video, text and multimedia content in the field of post-secondary education Printed matter, namely, books, pamphlets, brochures, manuals, booklets, leaflets, informational flyers, informational sheets and newsletters in the field of post-secondary education; printed publications, namely, books, pamphlets, brochures, manuals, booklets, leaflets, informational flyers, informational sheets and newsletters in the field of post-secondary education; printed posters; educational materials in written form, namely, books, pamphlets, brochures, manuals, booklets, leaflets, informational flyers, informational sheets and newsletters in the field of post-secondary education; printed books in the field of post-secondary education; printed publicity leaflets in the nature of flyers in the field of post-secondary education; printed newspapers; printed newsletters in the field of post-secondary education; printed periodicals in the field of post-secondary education; printed photographs; stationery; printed teaching materials for education, namely, books, pamphlets, brochures, manuals, booklets, leaflets, informational flyers, informational sheets and newsletters in the field of post-secondary education; printed teaching materials for instruction, namely, books, pamphlets, brochures, manuals, booklets, leaflets, informational flyers, informational sheets and newsletters in the field of post-secondary education; printed catalogues in the field of post-secondary education; printed brochures in the field of post-secondary education; writing pens Club education services, namely, classes, courses, workshops, retreats, camps and field trips in the field of post-secondary education; education services, namely, classes, courses, workshops, retreats, camps and field trips in the field of post-secondary education; educational services, namely, classes, courses, workshops, retreats, camps and field trips in the field of post-secondary education; teaching in the field of post-secondary education; personal development courses; personal development training; electronic publication of books, pamphlets, brochures, manuals, booklets, leaflets, informational flyers, informational sheets and newsletters in the field of post-secondary education, including online and over a global computer network; electronic publication of educational materials, namely, books, pamphlets, brochures, manuals, booklets, leaflets, informational flyers, informational sheets and newsletters in the field of post-secondary education; publishing of electronic publications; arranging and conducting of colloquiums in the field of post-secondary education; arranging and conducting of conferences in the field of post-secondary education; arranging and conducting of congresses in the field of post-secondary education; arranging and conducting of seminars in the field of post-secondary education; arranging and conducting of symposiums in the field of post-secondary education; arranging and conducting of workshops in the nature of training in the field of post-secondary education; lending library services; arranging of exhibitions for educational purposes; correspondence courses in the field of post-secondary education; vocational guidance; social club services in the nature of arranging, organizing and hosting entertainment, sporting and cultural services for club members; training in the field of post-secondary education; keynote speaking in the field of post-secondary education; providing international student exchange programmes
The present invention relates to recombinant microorganisms for producing biological hydrogen. In addition, the invention relates to nucleic acid constructs and processes for modifying microorganisms for enabling the production of hydrogen therefrom.
C12N 15/70 - Vecteurs ou systèmes d'expression spécialement adaptés à E. coli
C12N 9/02 - Oxydoréductases (1.), p. ex. luciférase
C12P 1/00 - Préparation de composés ou de compositions, non prévue dans les groupes , utilisant des micro-organismes ou des enzymesProcédés généraux de préparation de composés ou de compositions utilisant des micro-organismes ou des enzymes
C12P 1/04 - Préparation de composés ou de compositions, non prévue dans les groupes , utilisant des micro-organismes ou des enzymesProcédés généraux de préparation de composés ou de compositions utilisant des micro-organismes ou des enzymes utilisant des bactéries
C12P 3/00 - Préparation d'éléments ou de composés inorganiques à l'exception du dioxyde de carbone
H01M 8/16 - Éléments à combustible biochimique, c.-à-d. éléments dans lesquels des micro-organismes agissent comme catalyseurs
61.
TRANSISTOR ARRAY OR POWER AMPLIFIER WITH INBUILT THERMAL SENSOR
A power amplifier or other circuit with power transistors is disclosed, which includes structure for a thermal sensor. A metal structure is disposed proximate to heat generating transistors. The metal structure may be disposed between two transistors outside of the area occupied by the transistors. The metal structure may correspond to a gate of a field effect transistor or to a connector of a bipolar junction transistor. Operation of the power amplifier may be controlled based on a signal from the thermal sensor.
H03F 1/30 - Modifications des amplificateurs pour réduire l'influence des variations de la température ou de la tension d'alimentation
H03K 17/14 - Modifications pour compenser les variations de valeurs physiques, p. ex. de la température
H03K 19/003 - Modifications pour accroître la fiabilité
H03K 17/08 - Modifications pour protéger le circuit de commutation contre la surintensité ou la surtension
H01L 23/24 - Matériaux de remplissage caractérisés par le matériau ou par ses propriétes physiques ou chimiques, ou par sa disposition à l'intérieur du dispositif complet solide ou à l'état de gel, à la température normale de fonctionnement du dispositif
H01L 27/02 - Dispositifs consistant en une pluralité de composants semi-conducteurs ou d'autres composants à l'état solide formés dans ou sur un substrat commun comprenant des éléments de circuit passif intégrés avec au moins une barrière de potentiel ou une barrière de surface
C03C 3/087 - Compositions pour la fabrication du verre contenant de la silice avec 40 à 90% en poids de silice contenant de l'oxyde d'aluminium ou un composé du fer contenant un oxyde d'un métal divalent contenant de l'oxyde de calcium, p. ex. verre à vitre ordinaire ou verre pour récipients creux
C03C 3/091 - Compositions pour la fabrication du verre contenant de la silice avec 40 à 90% en poids de silice contenant du bore contenant de l'aluminium
C03C 3/085 - Compositions pour la fabrication du verre contenant de la silice avec 40 à 90% en poids de silice contenant de l'oxyde d'aluminium ou un composé du fer contenant un oxyde d'un métal divalent
G02B 6/13 - Circuits optiques intégrés caractérisés par le procédé de fabrication
Provided herein are methods for enhancing survival of a neuron, for inhibiting degeneration of a neuron, and for inhibiting abnormal protein accumulation in a neuron, optionally a motor neuron, comprising, consisting or consisting essentially of increasing the level of cyclin F in the neuron regardless of the neuron's level or activity of endogenous cyclin F. Optionally the neuron is in a subject with a neurodegenerative condition or at risk of developing a neurodegenerative condition, typically a neurodegenerative condition associated with a neuronal TDP-43 proteinopathy.
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
Provided herein are methods for enhancing survival of a neuron, for inhibiting degeneration of a neuron, and for inhibiting abnormal protein accumulation in a neuron, optionally a motor neuron, comprising, consisting or consisting essentially of increasing the level of cyclin F in the neuron regardless of the neuron's level or activity of endogenous cyclin F. Optionally the neuron is in a subject with a neurodegenerative condition or at risk of developing a neurodegenerative condition, typically a neurodegenerative condition associated with a neuronal TDP-43 proteinopathy.
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
Methods of treating a tauopathy in a subject by either administering full length isoform 2 of ρ38γ or its constitutively active mutant ρ38γ D179A. This promotes phosphorylation at threonine in the sequence SSPGSPGTPGSRSR of tau, equivalent to amino acid position threonine 205 (T205) of human tau. The methods also include introducing a phosphomimetic of a phosphorylated tau, wherein the phosphorylated tau has been phosphorylated at threonine in the sequence SSPGSPGTPGSRSR of the tau. The method of treatment results in improving the cognitive ability in a subject suffering from cognitive impairment associated with a tauopathy and reducing tau aggregates and neurofibrillary tangles.
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
A61K 31/7105 - Acides ribonucléiques naturels, c.-à-d. contenant uniquement des riboses liés à l'adénine, la guanine, la cytosine ou l'uracile et ayant des liaisons 3'-5' phosphodiester
C12N 15/11 - Fragments d'ADN ou d'ARNLeurs formes modifiées
Provided herein are methods for treating, delaying the onset of, or ameliorating at least one symptom of, dementia associated with -amyloid (A) accumulation, and for improving memory in subjects suffering from dementia associated with A accumulation, comprising administering to subjects in need thereof an effective amount of an inhibitor of LIMK1, wherein the inhibitor comprises a compound of Formula (I) as defined herein, or a pharmaceutically acceptable salt thereof. Also provided are methods for reducing A toxicity in neurons, comprising exposing neurons to an effective amount of an inhibitor of LIMK1, wherein the inhibitor comprises a compound of Formula (I) as defined herein, or a pharmaceutically acceptable salt thereof.
A61K 31/519 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
Disclosed herein are methods for treating or preventing an excitotoxicity-related condition, optionally a condition associated with seizures and/or resulting from or associated with a cerebral ischemic event, comprising administering to a subject in need an effective amount of an inhibitor of Lim-domain kinase 1 (LIMK1). Also provided are methods for treating or preventing seizures and for reducing excitotoxicity in neurons and/or protecting neurons from excitotoxicity.
A single longitudinal mode ring Raman laser including: a pump source outputting a pump light power, resonantly coupled to a first ring resonator; a optical measurement and piezo-actuator for stabilising the resonant coupling of the pump light power to a first ring resonator; a first ring resonator including a Raman gain medium, wherein the Raman gain medium receives the pump light power and undergoes Raman lasing generating resonated Stokes power at the corresponding Stokes output wavelength; the first ring resonator acting as a feedback loop for the pump light power and the resonated Stokes power and outputting a portion of the Stokes power as the laser output.
H01S 3/139 - Stabilisation de paramètres de sortie de laser, p. ex. fréquence ou amplitude par commande de la position relative ou des propriétés réfléchissantes des réflecteurs de la cavité
H01S 3/30 - Lasers, c.-à-d. dispositifs utilisant l'émission stimulée de rayonnement électromagnétique dans la gamme de l’infrarouge, du visible ou de l’ultraviolet utilisant des effets de diffusion, p. ex. l'effet Brillouin ou Raman stimulé
Provided herein are methods for treating or preventing, or ameliorating at least one symptom of, a neurodegenerative disease associated with TDP-43 pathology, comprising administering to a subject an effective amount of a peptide comprising or consisting of the amino acid sequence of SEQ ID NO:1 or a conservative variant thereof, optionally linked to a protein destabilization domain sequence, or a nucleic acid molecule encoding said peptide. Also provided is a peptide comprising or consisting of the amino acid sequence of SEQ ID NO:1 or a conservative variant thereof, a chimeric molecule comprising said peptide linked to a protein destabilization domain sequence, and a polynucleotide encoding said peptide or chimeric molecule.
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
A61K 38/00 - Préparations médicinales contenant des peptides
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
70.
DIAGNOSIS AND MONITORING OF NEURODEGENERATIVE DISEASES
Disclosed is a method for diagnosing a neurodegenerative disease in a subject. The method comprises obtaining from the subject a sample comprising at least one live blood cell, and optionally isolating at least one live blood cell from the sample. The method further comprises generating one or more multispectral or hyperspectral images of the at least one cell, and analysing spectral characteristics of autofluorescence from the at least one cell. Also disclosed is a system configured to aid in the detection or diagnosis of a neurodegenerative disease. Also disclosed is a method for selecting a subject for treatment for a neurodegenerative disease. Also disclosed is a method for monitoring the response of a subject to a therapeutic treatment for a neurodegenerative disease. Also disclosed is a protocol for monitoring the efficacy of a therapeutic treatment for a neurodegenerative disease.
09 - Appareils et instruments scientifiques et électriques
16 - Papier, carton et produits en ces matières
41 - Éducation, divertissements, activités sportives et culturelles
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Electronic publications; downloadable publications; computer
software; software applications; downloadable software
applications (apps), including for use with mobile phones
and other portable devices; software in the field of health
care; software applications (including for use with mobile
phones and other portable devices) for use in connection
with providing information and advice about mental health,
health care and medical matters; software applications
(including for use with mobile phones and other portable
devices) for use in connection with facilitating the
provision of health care services, including services
relating to mental health; software applications (including
for use with mobile phones and other portable devices) for
use in connection with locating or referring health and
medical practitioners; software applications (including for
use with mobile phones and other portable devices) for
sharing, exchanging and communicating graphics, images,
text, messages, audio, video, information and data online
and via computer, mobile, wireless, telecommunication and
social media networks; computer databases; none of the
aforesaid publications used for training and education on
how to provide child care services. Printed matter and publications; printed matter and
publications for educational purposes; printed matter and
publications relating to health education; printed matter
and publications relating to medical matters; printed matter
and publications relating to health matters; printed matter
and publications relating to mental health matters;
published works in the form of printed matter; periodical
publications relating to health, mental health and health
care; instructional and teaching material (except
apparatus); books; books including instructional and
educational books; magazines in this class; newsletters in
this class; publications in this class; none of the
aforesaid printed matter, publications, instructional or
teaching materials used for training and education on how to
provide child care services. Education services; training services; education services
regarding health; education services regarding mental
health; provision of education services relating to health
and mental health provided through various media, including
via website, software applications for mobile phones and
portable devices, telephone and SMS; publishing of printed
matter; dissemination of educational materials and programs;
publishing of printed matter relating to health and medical
matters, including in relation to mental health; publication
of information by any means (including online, by telephone
and SMS), including in relation to mental health and
education about health and mental health; none of the
aforementioned training and education services being
training and education on how to provide child care
services. Health care services; medical services; consultancy services
relating to mental health, health care and medical services;
advisory services relating to mental health, health care and
medical services; medical and health information, advice and
counselling; consultancy, advisory and information services
relating to mental health provided through various media,
including via website, software applications for mobile
phones and portable devices, telephone and SMS; arranging of
medical and health assessments, including mental health
assessments; arranging and conducting medical, health,
mental health, psychological and psychiatric assessments for
the purpose of referring individuals to suitable medical,
health, psychological and psychiatric practitioners and
resources; arranging and conducting medical, health, mental
health, psychological and psychiatric assessments through
various media, including via website, software applications
for mobile phones and portable devices, telephone and SMS;
health counselling, including mental health counselling;
medical counselling; psychological or psychiatric
counselling; health, mental health, medical, psychological
and psychiatric counselling services provided through
various media, including via website, software applications
for mobile phones and portable devices, telephone and SMS;
developing medical and health care programs, including in
relation to mental health; provision of information,
consultancy and advisory services regarding mental health,
health care and medical services; providing information by
any means (including online, by telephone and SMS) in
relation to mental health, medical services and health care
services, including in relation to all of the foregoing
services.
The technology relates to recombinant yeast comprising at least one copy of an expression cassette comprising a constitutive or inducible promoter operatively coupled to a nucleic acid sequence encoding a vanadate-dependent bromoperoxidase (vBPO). The expression cassette may further comprise a nucleic acid sequence encoding a peroxisomal targeting signal and a transcription termination sequence. The yeast are used to produce bromoform and can be used as an animal feed or fed supplement to reduce methane production in animal digestive tracts.
C12N 15/81 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour champignons pour levures
A23K 10/18 - Ajout de micro-organismes ou de leurs produits d’extraction, p. ex. de protéines provenant d’organismes unicellulaires, à des compositions de produits alimentaires de micro-organismes vivants
THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (Australie)
MACQUARIE UNIVERSITY (Australie)
Inventeur(s)
Harrison, Leonard Charles
Bandala-Sanchez, Esther
Goddard-Borger, Ethan David
Packer, Nicolle Hannah
Mansour, Shathili Abdulrahman
Abrégé
The present disclosure relates to glycoprotein CD52 and fusion proteins thereof, wherein the CD52 glycoprotein has α-2,3-sialylated N-glycans, O-glycosylation and a pI of about 5 to about 6. The disclosure further relates to the preparation and purification of these proteins and their use in the suppression of effector T-cell function and/or immune response, such as in the treatment of diseases or conditions mediated by effector T-cell function.
The present invention relates to complexes comprising probucol or derivatives thereof and mesoporous silica, methods for producing such complexes and uses thereof. The present invention also relates to uses of the complexes in the treatment of inflammation- and oxidation-related diseases and disorders.
A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p. ex. émulsion, particule, complexe d’inclusion, stent ou kit
A61K 9/14 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres
A61P 9/10 - Médicaments pour le traitement des troubles du système cardiovasculaire des maladies ischémiques ou athéroscléreuses, p. ex. médicaments antiangineux, vasodilatateurs coronariens, médicaments pour le traitement de l'infarctus du myocarde, de la rétinopathie, de l'insuffisance cérébro-vasculaire, de l'artériosclérose rénale
Disclosed herein are methods for causing weight loss, for managing weight, and for suppressing an appetite for food in a subject, and methods for reducing the consumption of food by a subject by administering the compounds, or pharmaceutically acceptable salts or prodrugs thereof, of the invention.
A61K 31/5517 - 1,4-Benzodiazépines, p. ex. diazépam condensées avec des cycles à cinq chaînons ayant l'azote comme hétéro-atome d'un cycle, p. ex. imidazobenzodiazépines, triazolam
A61K 31/553 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole ayant au moins un azote et au moins un oxygène comme hétéro-atomes d'un cycle, p. ex. loxapine, staurosporine
A61K 31/554 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole ayant au moins un azote et au moins un soufre comme hétéro-atomes d'un cycle, p. ex. clothiapine, diltiazem
A frequency electromagnetic radiation generation system including: a non linear crystal producing THz frequency electromagnetic radiation; a fundamental beam that interacts with the non linear crystal thereby emitting a THz frequency electromagnetic radiation emission; a silicon intermediary coupled to the non linear crystal for output channeling the THz frequency electromagnetic radiation emission to an output environment; the system utilising a fundamental beam which has a photon energy below the bandgap energy of silicon.
H01S 3/30 - Lasers, c.-à-d. dispositifs utilisant l'émission stimulée de rayonnement électromagnétique dans la gamme de l’infrarouge, du visible ou de l’ultraviolet utilisant des effets de diffusion, p. ex. l'effet Brillouin ou Raman stimulé
H01S 1/02 - Masers, c.-à-d. dispositifs utilisant l’émission stimulée de rayonnement électromagnétique dans la gamme des micro-ondes solides
H01S 3/108 - Commande de l'intensité, de la fréquence, de la phase, de la polarisation ou de la direction du rayonnement, p. ex. commutation, ouverture de porte, modulation ou démodulation par commande de dispositifs placés dans la cavité utilisant des dispositifs optiques non linéaires, p. ex. produisant une diffusion par effet Brillouin ou Raman
H01S 3/11 - Blocage de modesCommutation-QAutres techniques d'impulsions géantes, p. ex. vidange de cavité
System and method for for obtaining auditory evoked potentials from apical portions of the cochlea are described. The system comprises: a computing device configured to: generate an auditory stimulation signal having a characteristic frequency (cf) in the frequency range of the apical region, the auditory stimulation signal comprising a one-period sinusoidal signal having a duration in the region of 1/cf seconds, transmit the generated auditory stimulation signal at an average rate of cf to an audio output device in communication with a subject; receive overlapping auditory evoked responses from one or more electrodes connected to the subject, the auditory evoked responses generated by the subject in response to the auditory stimulation signal; deconvolve the received overlapping auditory evoked responses to create a disentangled record of the responses.
Reducing abnormal accumulation of TDP-43 in motor neurons in amyotrophic lateral sclerosis and/or frontotemporal dementia using a construct encoding cyclin F
Disclosed are compositions and methods for inhibiting abnormal protein accumulation, promoting motor neuron survival, inhibiting motor neuron degeneration and treating neurodegenerative conditions through expression of a nucleic acid sequence encoding cyclin F in motor neurons with an abnormally low level or activity of cyclin F. Also disclosed are methods for identifying agents that promote survival of motor neurons, inhibit degeneration of motor neurons and/or inhibit abnormal protein accumulation in motor neurons, identifying agents that are useful for treating neurodegenerative conditions, diagnosing neurodegenerative conditions, predicting the progression of neurodegenerative conditions, and monitoring the effectiveness of a therapy in reducing the progression of a neurodegenerative condition.
C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteursVecteurs Utilisation d'hôtes pour ceux-ciRégulation de l'expression
C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
Iterative methods for direction of arrival estimation of a signal at a receiver with a plurality of spatially separated sensor elements are described. A quantized estimate of the angle of arrival is obtained from a compressive sensing solution of a set of equations. The estimate is refined in a subsequent iteration by a computed error based a quantized estimate of the direction of arrival in relation to quantization points offset from the quantization points for the first quantized estimate of the angle of arrival. The iterations converge on an estimated direction of arrival.
G01S 3/04 - Radiogoniomètres pour déterminer la direction d'où proviennent des ondes infrasonores, sonores, ultrasonores ou électromagnétiques ou des émissions de particules sans caractéristiques de direction utilisant des ondes radio Détails
G01S 3/48 - Systèmes pour déterminer une direction ou une déviation par rapport à une direction prédéterminée en utilisant des antennes espacées et en mesurant la différence de phase ou de temps entre les signaux venant de ces antennes, c.-à-d. systèmes à différence de parcours les ondes arrivant aux antennes étant continues ou intermittentes et la différence de phase entre les signaux provenant de ces antennes étant mesurée
G01S 3/72 - Systèmes à diversité spécialement adaptés à la radiogoniométrie
G01S 3/80 - Radiogoniomètres pour déterminer la direction d'où proviennent des ondes infrasonores, sonores, ultrasonores ou électromagnétiques ou des émissions de particules sans caractéristiques de direction utilisant des ondes ultrasonores, sonores ou infrasonores
80.
Optical signal transmission system, a method for transmitting a plurality of optical signals, and a method for making a photonic device
An optical signal transmission system comprising a multimode optical fiber link. The multimode optical fiber link is for transmission of a plurality of optical signals in a plurality of spatial modes supported by the multimode optical fiber link. The optical signal transmission system comprises a photonic device in the form of a spatial mode add drop multiplexer coupled to the multimode optical fiber link and configured for at least one of coupling into the multimode optical fiber link an optical signal of the plurality of optical signals into a spatial mode of the plurality of spatial modes and coupling out of the multimode optical fiber link and into an optical fiber the optical signal of the spatial mode.
An unmounted insertable retractor for separating anatomical structures during surgery, anatomical investigations or the like, the retractor having a body with a passage therethrough, the body configured to be placed between anatomical structures to be separated.
A probe for optically imaging a pathway and associated methods is described. The probe includes a series of optical imaging units that include a beam splitter that rotates about an axis. The beam splitter directs a first portion of sensing light traversing a light path out from the probe in a radial direction onto a wall portion of the pathway and passes a second portion of the sensing light towards an adjacent optical imaging unit of the probe. Returned light from the wall portion of the pathway is received and directed back along the light path.
G02B 23/24 - Instruments pour regarder l'intérieur de corps creux, p. ex. endoscopes à fibres
A61B 1/00 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments
Disclosed are recombinant microorganisms and methods of producing propionate (propionic acid) and 1-propanol. In particular, the present invention discloses microorganisms engineered to produce propionate and 1-propanol via a recombinant Wood-Werkman cycle and methods of using the recombinant microorganisms to produce propionate and 1-propanol from sugars and other substrates.
C12N 1/00 - Micro-organismes, p. ex. protozoairesCompositions les contenantProcédés de culture ou de conservation de micro-organismes, ou de compositions les contenantProcédés de préparation ou d'isolement d'une composition contenant un micro-organismeLeurs milieux de culture
The present invention relates to methods, systems and devices for safely and efficiently capturing gaseous mercury and removing the mercury from an environment. A device of the present invention may comprise a sorbent material, a porous body and a means of binding the sorbent material to the body. The gaseous mercury may be captured by such a device upon contact of the mercury with the sorbent material and, after use, be safely removed from the environment.
C02F 1/28 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par absorption ou adsorption
C02F 3/34 - Traitement biologique de l'eau, des eaux résiduaires ou des eaux d'égout caractérisé par les micro-organismes utilisés
B01J 20/02 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation contenant une substance inorganique
B01J 20/30 - Procédés de préparation, de régénération ou de réactivation
B01D 15/00 - Procédés de séparation comportant le traitement de liquides par des adsorbants ou des absorbants solidesAppareillages pour ces procédés
B09C 1/10 - Régénération de sols pollués par des procédés microbiologiques ou utilisant des enzymes
B01J 20/22 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation contenant une substance organique
B01D 53/02 - Séparation de gaz ou de vapeursRécupération de vapeurs de solvants volatils dans les gazÉpuration chimique ou biologique des gaz résiduaires, p. ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par adsorption, p. ex. chromatographie préparatoire en phase gazeuse
B01D 53/14 - Séparation de gaz ou de vapeursRécupération de vapeurs de solvants volatils dans les gazÉpuration chimique ou biologique des gaz résiduaires, p. ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par absorption
The present application describes a class of peptides comprising from (2) to (12) amino acid residues, wherein: the N-terminus of the peptide is linked to an optionally substituted, fused polycyclic group comprising an aromatic ring; at least one amino acid residue has a hydrophobic side chain; at least two amino acid residues have a cation-containing side chain, or at least one amino acid residue has two or more cation-containing side chains, or at least one amino acid residue has one or more side chains comprising two or more cations; and the net charge of the peptide is positive at a pH of from about (4) to about (10). The present application also describes hydrogels and cell culture substrates comprising the peptides, as well as the use of the cell culture substrates for culturing cells.
09 - Appareils et instruments scientifiques et électriques
16 - Papier, carton et produits en ces matières
41 - Éducation, divertissements, activités sportives et culturelles
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Electronic publications; downloadable publications; computer
software; software applications; downloadable software
applications (Apps), including for use with mobile phones
and other portable devices; software in the field of health
care; software applications (including for use with mobile
phones and other portable devices) for use in connection
with providing information and advice about mental health,
health care and medical matters; software applications
(including for use with mobile phones and other portable
devices) for use in connection with facilitating the
provision of health care services, including services
relating to mental health; software applications (including
for use with mobile phones and other portable devices) for
use in connection with locating or referring health and
medical practitioners; software applications (including for
use with mobile phones and other portable devices) for
sharing, exchanging and communicating graphics, images,
text, messages, audio, video, information and data online
and via computer, mobile, wireless, telecommunication and
social media networks; computer databases. Printed matter and publications; printed matter and
publications for educational purposes; printed matter and
publications relating to health education; printed matter
and publications relating to medical matters; printed matter
and publications relating to health matters; printed matter
and publications relating to mental health matters;
published works in the form of printed matter; periodical
publications relating to health, mental health and health
care; instructional and teaching material (except
apparatus); books; books including instructional and
educational books; magazines in this class; newsletters in
this class; publications in this class. Education services; training services; education services
regarding health; education services regarding mental
health; provision of education services relating to health
and mental health provided through various media, including
via website, software applications for mobile phones and
portable devices, telephone and SMS; publishing of printed
matter; dissemination of educational materials and programs;
publishing of printed matter relating to health and medical
matters, including in relation to mental health; publication
of information by any means (including online, by telephone
and SMS), including in relation to mental health and
education about health and mental health. Health care services; medical services; consultancy services
relating to mental health, health care and medical services;
advisory services relating to mental health, health care and
medical services; medical and health information, advice and
counselling; consultancy, advisory and information services
relating to mental health provided through various media,
including via website, software applications for mobile
phones and portable devices, telephone and SMS; provision of
health care referral services, including via website,
software applications for mobile phones and portable
devices, telephone and SMS; arranging of medical and health
assessments, including mental health assessments; arranging
and conducting medical, health, mental health, psychological
and psychiatric assessments for the purpose of referring
individuals to suitable medical, health, psychological and
psychiatric practitioners and resources; arranging and
conducting medical, health, mental health, psychological and
psychiatric assessments through various media, including via
website, software applications for mobile phones and
portable devices, telephone and SMS; health counselling,
including mental health counselling; medical counselling;
psychological or psychiatric counselling; health, mental
health, medical, psychological and psychiatric counselling
services provided through various media, including via
website, software applications for mobile phones and
portable devices, telephone and SMS; developing medical and
health care programs, including in relation to mental
health; provision of information, consultancy and advisory
services regarding mental health, health care and medical
services; providing information by any means (including
online, by telephone and SMS) in relation to mental health,
medical services and health care services, including in
relation to all of the foregoing services.
09 - Appareils et instruments scientifiques et électriques
16 - Papier, carton et produits en ces matières
41 - Éducation, divertissements, activités sportives et culturelles
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Electronic publications; downloadable publications; computer
software; software applications; downloadable software
applications (Apps), including for use with mobile phones
and other portable devices; software in the field of health
care; software applications (including for use with mobile
phones and other portable devices) for use in connection
with providing information and advice about mental health,
health care and medical matters; software applications
(including for use with mobile phones and other portable
devices) for use in connection with facilitating the
provision of health care services, including services
relating to mental health; software applications (including
for use with mobile phones and other portable devices) for
use in connection with locating or referring health and
medical practitioners; software applications (including for
use with mobile phones and other portable devices) for
sharing, exchanging and communicating graphics, images,
text, messages, audio, video, information and data online
and via computer, mobile, wireless, telecommunication and
social media networks; computer databases. Printed matter and publications; printed matter and
publications for educational purposes; printed matter and
publications relating to health education; printed matter
and publications relating to medical matters; printed matter
and publications relating to health matters; printed matter
and publications relating to mental health matters;
published works in the form of printed matter; periodical
publications relating to health, mental health and health
care; instructional and teaching material (except
apparatus); books; books including instructional and
educational books; magazines in this class; newsletters in
this class; publications in this class. Education services; training services; education services
regarding health; education services regarding mental
health; provision of education services relating to health
and mental health provided through various media, including
via website, software applications for mobile phones and
portable devices, telephone and SMS; publishing of printed
matter; dissemination of educational materials and programs;
publishing of printed matter relating to health and medical
matters, including in relation to mental health; publication
of information by any means (including online, by telephone
and SMS), including in relation to mental health and
education about health and mental health. Health care services; medical services; consultancy services
relating to mental health, health care and medical services;
advisory services relating to mental health, health care and
medical services; medical and health information, advice and
counselling; consultancy, advisory and information services
relating to mental health provided through various media,
including via website, software applications for mobile
phones and portable devices, telephone and SMS; provision of
health care referral services, including via website,
software applications for mobile phones and portable
devices, telephone and SMS; arranging of medical and health
assessments, including mental health assessments; arranging
and conducting medical, health, mental health, psychological
and psychiatric assessments for the purpose of referring
individuals to suitable medical, health, psychological and
psychiatric practitioners and resources; arranging and
conducting medical, health, mental health, psychological and
psychiatric assessments through various media, including via
website, software applications for mobile phones and
portable devices, telephone and SMS; health counselling,
including mental health counselling; medical counselling;
psychological or psychiatric counselling; health, mental
health, medical, psychological and psychiatric counselling
services provided through various media, including via
website, software applications for mobile phones and
portable devices, telephone and SMS; developing medical and
health care programs, including in relation to mental
health; provision of information, consultancy and advisory
services regarding mental health, health care and medical
services; providing information by any means (including
online, by telephone and SMS) in relation to mental health,
medical services and health care services, including in
relation to all of the foregoing services.
88.
IMPROVEMENTS IN TERAHERTZ LASERS AND TERAHERTZ EXTRACTION
A frequency electromagnetic radiation generation system including: a non linear crystal producing THz frequency electromagnetic radiation; a fundamental beam that interacts with the non linear crystal thereby emitting a THz frequency electromagnetic radiation emission; a silicon intermediary coupled to the non linear crystal for output channeling the THz frequency electromagnetic radiation emission to an output environment; the system utilising a fundamental beam which has a photon energy below the bandgap energy of silicon.
The technology relates to a remote ischemic preconditioning system having a cuff configured to contract about a limb of a subject; an actuator connected to the cuff that, when actuated, causes the cuff to contract about the limb of the subject; a controller that controls the actuator to operate according to a treatment protocol that includes a plurality of treatment cycles of contracting and releasing the cuff about the limb of a subject; a first sensor for measuring oxygen saturation level in the blood of the limb; a second sensor for measuring a pulse property in the limb; and a feedback control unit in communication with the controller and configured to receive the oxygen saturation measurement from the first sensor and the pulse property from the second sensor; wherein the feedback control unit is further configured to: compare the oxygen saturation level to a first predetermined value and signal the controller to operate the actuator to further inflate the cuff if the oxygen saturation level is above the predetermined value; and compare the pulse property to a second predetermined value and signal the controller to operate the actuator to further inflate the cuff if the pulse rate or pulse strength is above the predetermined value.
A61B 5/0225 - Mesure de la pression dans le cœur ou dans les vaisseaux sanguins par application d'une pression pour fermer les vaisseaux sanguins, p. ex. contre la peauOphtalmodynamomètres la pression étant commandée par des signaux électriques, p. ex. dérivés des bruits de Korotkoff
A61B 5/025 - Mesure du pouls ou des pulsations cardiaques utilisant des capteurs engendrant des signaux électriques à l'intérieur de dispositifs d'occlusion, p. ex. en réponse à des bruits de Korotkoff
The present invention relates to methods for engineering yeast strains which can be used in the production of industrially important chemicals. Nucleic acids encoding components of the methanol utilization pathway are used to modify yeast cells such as Saccharomyces cerevisiae to enable them to grow in media in which methanol is the only or main energy source. The nucleic acids may encode proteins including alcohol oxidase, dihydroxyacetone synthase, dihydroxyacetone kinase, fructose- 1-6-bisphosphate aldolase, fructose-1-6-bisphosphatase, sedoheptulose bisphosphatase, ribose-5-phosphate isomerase, D-ribulose-5-phosphate-3-epimerase, transketolase 1 or 2, transaldolase and formaldehyde dehydrogenase.
A single longitudinal mode ring Raman laser including: a pump source outputting a pump light power, resonantly coupled to a first ring resonator; a optical measurement and piezo-actuator for stabilising the resonant coupling of the pump light power to a first ring resonator; a first ring resonator including a Raman gain medium, wherein the Raman gain medium receives the pump light power and undergoes Raman lasing generating resonated Stokes power at the corresponding Stokes output wavelength; the first ring resonator acting as a feedback loop for the pump light power and the resonated Stokes power and outputting a portion of the Stokes power as the laser output.
H01S 3/086 - Structure ou forme des résonateurs optiques ou de leurs composants un ou plusieurs réflecteurs ayant des propriétés ou positions variables pour le réglage initial du résonateur
H01S 3/091 - Procédés ou appareils pour l'excitation, p. ex. pompage utilisant le pompage optique
H01S 3/105 - Commande de l'intensité, de la fréquence, de la phase, de la polarisation ou de la direction du rayonnement, p. ex. commutation, ouverture de porte, modulation ou démodulation par commande de la position relative ou des propriétés réfléchissantes des réflecteurs de la cavité
H01S 3/108 - Commande de l'intensité, de la fréquence, de la phase, de la polarisation ou de la direction du rayonnement, p. ex. commutation, ouverture de porte, modulation ou démodulation par commande de dispositifs placés dans la cavité utilisant des dispositifs optiques non linéaires, p. ex. produisant une diffusion par effet Brillouin ou Raman
H01S 3/30 - Lasers, c.-à-d. dispositifs utilisant l'émission stimulée de rayonnement électromagnétique dans la gamme de l’infrarouge, du visible ou de l’ultraviolet utilisant des effets de diffusion, p. ex. l'effet Brillouin ou Raman stimulé
A single longitudinal mode ring Raman laser including: a pump source outputting a pump light power, resonantly coupled to a first ring resonator; a optical measurement and piezo-actuator for stabilising the resonant coupling of the pump light power to a first ring resonator; a first ring resonator including a Raman gain medium, wherein the Raman gain medium receives the pump light power and undergoes Raman lasing generating resonated Stokes power at the corresponding Stokes output wavelength; the first ring resonator acting as a feedback loop for the pump light power and the resonated Stokes power and outputting a portion of the Stokes power as the laser output.
H01S 3/30 - Lasers, c.-à-d. dispositifs utilisant l'émission stimulée de rayonnement électromagnétique dans la gamme de l’infrarouge, du visible ou de l’ultraviolet utilisant des effets de diffusion, p. ex. l'effet Brillouin ou Raman stimulé
H01S 3/086 - Structure ou forme des résonateurs optiques ou de leurs composants un ou plusieurs réflecteurs ayant des propriétés ou positions variables pour le réglage initial du résonateur
H01S 3/091 - Procédés ou appareils pour l'excitation, p. ex. pompage utilisant le pompage optique
H01S 3/105 - Commande de l'intensité, de la fréquence, de la phase, de la polarisation ou de la direction du rayonnement, p. ex. commutation, ouverture de porte, modulation ou démodulation par commande de la position relative ou des propriétés réfléchissantes des réflecteurs de la cavité
H01S 3/108 - Commande de l'intensité, de la fréquence, de la phase, de la polarisation ou de la direction du rayonnement, p. ex. commutation, ouverture de porte, modulation ou démodulation par commande de dispositifs placés dans la cavité utilisant des dispositifs optiques non linéaires, p. ex. produisant une diffusion par effet Brillouin ou Raman
Disclosed are compositions and methods for inhibiting abnormal protein accumulation, promoting motor neuron survival, inhibiting motor neuron degeneration and treating neurodegenerative conditions through expression of a nucleic acid sequence encoding cyclin F in motor neurons with an abnormally low level or activity of cyclin F. Also disclosed are methods for identifying agents that promote survival of motor neurons, inhibit degeneration of motor neurons and/or inhibit abnormal protein accumulation in motor neurons, identifying agents that are useful for treating neurodegenerative conditions, diagnosing neurodegenerative conditions, predicting the progression of neurodegenerative conditions, and monitoring the effectiveness of a therapy in reducing the progression of a neurodegenerative condition.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
Iterative methods for direction of arrival estimation of a signal at a receiver with a plurality of spatially separated sensor elements are described. A quan- tized estimate of the angle of arrival is obtained from a compressive sensing solution of a set of equations. The estimate is refined in a subsequent iteration by a computed error based a quantized estimate of the direction of arrival in relation to quantization points offset from the quantization points for the first quantized estimate of the angle of arrival. The iterations converge on an estimated direction of arrival.
G01S 3/00 - Radiogoniomètres pour déterminer la direction d'où proviennent des ondes infrasonores, sonores, ultrasonores ou électromagnétiques ou des émissions de particules sans caractéristiques de direction
G01S 5/00 - Localisation par coordination de plusieurs déterminations de direction ou de ligne de positionLocalisation par coordination de plusieurs déterminations de distance
Iterative methods for direction of arrival estimation of a signal at a receiver with a plurality of spatially separated sensor elements are described. A quantized estimate of the angle of arrival is obtained from a compressive sensing solution of a set of equations. The estimate is refined in a subsequent iteration by a computed error based a quantized estimate of the direction of arrival in relation to quantization points offset from the quantization points for the first quantized estimate of the angle of arrival. The iterations converge on an estimated direction of arrival.
G01S 3/00 - Radiogoniomètres pour déterminer la direction d'où proviennent des ondes infrasonores, sonores, ultrasonores ou électromagnétiques ou des émissions de particules sans caractéristiques de direction
G01S 5/00 - Localisation par coordination de plusieurs déterminations de direction ou de ligne de positionLocalisation par coordination de plusieurs déterminations de distance
09 - Appareils et instruments scientifiques et électriques
16 - Papier, carton et produits en ces matières
35 - Publicité; Affaires commerciales
41 - Éducation, divertissements, activités sportives et culturelles
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
(1) Downloadable electronic publications in the nature of books, magazines and newsletters; downloadable periodical publications; downloadable electronic publications in the field of college courses and higher education; computer software for providing information and advice in the field of mental health, medicine, patient care and health education; software applications for providing information and advice in the field of mental health, medicine, patient care, health education; downloadable software applications for providing information and advice in the field of mental health, medicine, patient care, health education for use with mobile phones, tablets, computers, smart watches, e-readers and personal digital assistants; software for providing information in the field of mental health, medicine, patient care and health education; software applications for use with mobile phones, tablets, computers, smart watches, e-readers and personal digital assistants for use in connection with providing information and advice about mental health, medicine, patient care and health education; software applications for use with mobile phones, tablets, computers, smart watches, e-readers and personal digital assistants to facilitate the provision of health care services, namely mental health; software applications for use with mobile phones, tablets, computers, smart watches, ereaders and personal digital assistants to locate and refer health and medical practitioners; software applications for use with mobile phones, tablets, computers, smart watches, e-readers and personal digital assistants for sharing, exchanging and communicating downloadable graphics, digital images, text, messages, audio recordings, video recordings, information and data in the field of health education, wellbeing, medical matters, health matters and mental health matters online and via computer, mobile, wireless,telecommunication and social media networks; computer databases containing information in the fields of health education, medicine, patient care and mental health recorded on computer media.
(2) Printed matter, namely magazines, books, newsletters, brochures, written articles; printed matter and publications for educational purposes, namely higher education and health education; printed matter and publications relating to health education; printed matter and publications relating to medical matters; printed matter and publications relating to health matters; printed matter and publications relating to mental health matters; periodical publications relating to health, mental health and health care; instructional and teaching materials, namely textbooks, written articles, white papers; books; instructional and educational books; magazines; newsletters. (1) Education services in the fields of patient care, health education, general health and well-being, medicine and mental health; training services in the fields of patient care, health education, general health and wellbeing, medicine and mental health; education services regarding mental health; provision of education services relating to health education, general health and well-being, medicine, medical matters and mental health provided via a website and software applications for mobile phones, telephone, SMS, tablets, computers, smart watches, e-readers and personal digital assistants; dissemination of educational materials and programs, namely books, manuals, brochures, informational pamphlets, courses, webinars, and conferences in the field of medical matters, general health and wellbeing, medicine, health education, mental health; publishing of books, magazines and newsletters relating to health and medical matters, namely, in the field of health matters, general health and well-being, medicine, health education, mental health; publication of information via online, telephone and SMS in relation to mental health and health education.
(2) Health care services for diagnosing and treating mental health disorders; medical services for diagnosing and treating mental health disorders; consultancy services relating to mental health, general health and wellbeing, medicine, patient care, and health education; advisory services relating to mental health, general health and well-being, medicine, patient care, and health education; medical and health information, advice and counselling in the field of mental health, medicine, patient care, and health education; consultancy, advisory and information services relating to mental health provided through various media, namely via website, software applications for mobile phones, tablets, computers, smart watches, e-readers, personal digital assistants, telephone and SMS; provision of health care referral services, namely via website, software applications for mobile phones tablets, computers, smart watches, e-readers, personal digital assistants, telephone and SMS; arranging of medical and health assessments, namely mental health assessments; arranging and conducting medical, health, mental health, psychological and psychiatric assessments for the purpose of referring individuals to suitable medical, health, psychological and psychiatric practitioners and resources; arranging and conducting medical, health, mental health, psychological and psychiatric assessments through various media, namely via website, software applications for mobile phones tablets, computers, smart watches, e-readers and personal digital assistants, telephone and SMS; health counselling, namely mental health counselling; medical counselling namely mental health, medicine, patient care and health education counselling; psychological counselling; psychiatric counselling; Health education, mental health, medicine, psychological and psychiatric counselling services provided via a website, and software applications for mobile phones, telephone, SMS, tablets, computers, smart watches, e-readers and personal digital assistants; developing medical and health care programs, developing psychological and psychiatric counselling, general well-being and mental health care programs; provision of information, consultancy and advisory services regarding mental health, general well-being, medicine, health education, mental health counselling, psychological counselling and psychiatric counselling; providing information via online, mobile phone, tablets, computers, smart watches, e-readers, personal digital assistants, telephone and SMS in the field of mental health, general well-being, psychological and psychiatric counselling, psychological and psychiatric assessment, psychological and psychiatric counselling referrals, medicine, health education, mental health counselling, psychological counselling and psychiatric counselling.
09 - Appareils et instruments scientifiques et électriques
16 - Papier, carton et produits en ces matières
35 - Publicité; Affaires commerciales
41 - Éducation, divertissements, activités sportives et culturelles
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
(1) Downloadable electronic publications in the nature of books, magazines and newsletters; downloadable periodical publications; downloadable electronic publications in the field of college courses and higher education; computer software for providing information and advice in the field of mental health, medicine, patient care and health education; software applications for providing information and advice in the field of mental health, medicine, patient care, health education; downloadable software applications for providing information and advice in the field of mental health, medicine, patient care, health education for use with mobile phones, tablets, computers, smart watches, e-readers and personal digital assistants; software providing information in the field of mental health, medicine, patient care and health education; software applications for use with mobile phones, tablets, computers, smart watches, e-readers and personal digital assistants for use in connection with providing information and advice about mental health, medicine, patient care and health education; software applications for use with mobile phones, tablets, computers, smart watches, e-readers and personal digital assistants to facilitate the provision of health care services, namely mental health; software applications for use with mobile phones, tablets, computers, smart watches, ereaders, personal digital assistants to locate and refer health and medical practitioners; software applications for use with mobile phones, tablets, computers, smart watches, e-readers, personal digital assistants for sharing, exchanging and communicating downloadable graphics, digital images, text, messages, audio recordings, video recordings, information and data in the field of health education, well-being, medical matters, health matters and mental health matters online and via computer, mobile, wireless, telecommunication and social media networks; computer databases containing information in the fields of health education, medicine, patient care and mental health recorded on computer media.
(2) Printed matter, namely magazines, books, newsletters, brochures, written articles; printed matter and publications for educational purposes, namely higher education and health education; printed matter and publications relating to health education; printed matter and publications relating to medical matters; printed matter and publications relating to health matters; printed matter and publications relating to mental health matters; periodical publications relating to health, mental health and health care; instructional and teaching materials, namely textbooks, written articles, white papers; books; instructional and educational books; magazines; newsletters. (1) Education services in the fields of patient care, health education, general health and well-being, medicine and mental health; training services in the fields of patient care, health education, general health and wellbeing, medicine and mental health; education services regarding mental health; provision of education services relating to health education, general health and well-being, medicine, medical matters and mental health provided via a website and software applications for mobile phones, telephone, SMS, tablets, computers, smart watches, e-readers and personal digital assistants; dissemination of educational materials and programs, namely books, manuals, brochures, informational pamphlets, courses, webinars, and conferences in the field of medical matters, general health and wellbeing, medicine, health education, mental health; publication of information via online, telephone and SMS in relation to mental health and health education.
(2) Health care services for diagnosing and treating mental health disorders; medical services for diagnosing and treating mental health disorders; consultancy services relating to mental health, general health and wellbeing, medicine, patient care, and health education; advisory services relating to mental health, general health and well-being, medicine, patient care, and health education; medical and health information, advice and counselling in the field of mental health, medicine, patient care, and health education; consultancy, advisory and information services relating to mental health provided through various media, namely via website, software applications for mobile phones, tablets, computers, smart watches, e-readers, personal digital assistants, telephone and SMS; provision of health care referral services, namely via website, software applications for mobile phones tablets, computers, smart watches, e-readers, personal digital assistants, telephone and SMS; arranging of medical and health assessments, namely mental health assessments; arranging and conducting medical, health, mental health, psychological and psychiatric assessments for the purpose of referring individuals to suitable medical, health, psychological and psychiatric practitioners and resources; arranging and conducting medical, health, mental health, psychological and psychiatric assessments through various media, namely via website, software applications for mobile phones tablets, computers, smart watches, e-readers and personal digital assistants, telephone and SMS; health counselling, namely mental health counselling; medical counselling namely mental health, medicine, patient care and health education counselling; psychological counselling; psychiatric counselling; Health education, mental health, medicine, psychological and psychiatric counselling services provided via a website, and software applications for mobile phones, telephone, SMS, tablets, computers, smart watches, e-readers and personal digital assistants; developing medical and health care programs, developing psychological and psychiatric counselling, general well-being and mental health care programs; provision of information, consultancy and advisory services regarding mental health, general well-being, medicine, health education, mental health counselling, psychological counselling and psychiatric counselling; providing information via online, mobile phone, tablets, computers, smart watches, e-readers, personal digital assistants, telephone and SMS in the field of mental health, general well-being, psychological and psychiatric counselling, psychological and psychiatric assessment, psychological and psychiatric counselling referrals, medicine, health education, mental health counselling, psychological counselling and psychiatric counselling.
98.
CASCADED, LONG PULSE AND CONTINUOUS WAVE RAMAN LASERS
A Raman Laser device having an nth Stokes shifted output the device including: a laser pump input; a lasing cavity having feedback elements at each end; and a diamond Raman active gain medium within the cavity, exhibiting first and higher Stokes emissions when subjected to pumping by the laser pump input; wherein the feedback elements feeding back the pump input, and 1st Stokes output from the gain medium, and a gain portion of the higher Stokes outputs, with a transmitting portion of the nth Stokes output being the output of the device.
H01S 3/30 - Lasers, c.-à-d. dispositifs utilisant l'émission stimulée de rayonnement électromagnétique dans la gamme de l’infrarouge, du visible ou de l’ultraviolet utilisant des effets de diffusion, p. ex. l'effet Brillouin ou Raman stimulé
There is disclosed a nasogastric pump for the extraction of fluid from the stomach of a patient. The nasogastric pump comprises an elongate tube and a pump apparatus. The elongate tube is adapted for placement through the nasal cavity of a patient and into the stomach of the patient such that a distal end thereof is disposed in the stomach of the patient. The pump apparatus is housed within the distal end of the tube. The pump apparatus is adapted to admit fluid therein from the stomach of the patient and to positively displace fluid from the pump apparatus towards a proximal end of the tube.
Disclosed herein is an optical signal transmission system (10). The optical signal transmission system (10) comprises a multimode optical fibre link (12). The multimode optical fibre link (12) is for transmission of a plurality of optical signals in a plurality of spatial modes supported by the multimode optical fibre link (12). The optical signal transmission system (10) comprises a photonic device in the form of a spatial mode add drop multiplexer (14) coupled to the multimode optical fibre link (12) and configured for at least one of coupling into the multimode optical fibre link (12) an optical signal of the plurality of optical signals into a spatial mode of the plurality of spatial modes and coupling out of the multimode optical fibre link (12) and into an optical fibre (16) the optical signal of the spatial mode.
