Abrégé

A blister packaging for a pharmaceutical cartridge or capsule and methods of forming same are disclosed.

Classes IPC  ?

• A61M 15/00 - Inhalateurs
• A61J 1/03 - Récipients spécialement adaptés à des fins médicales ou pharmaceutiques pour pilules ou comprimés
• B29C 51/14 - Façonnage par thermoformage, p. ex. façonnage de feuilles dans des moules en deux parties ou par emboutissage profondAppareils à cet effet de préformes ou de feuilles multicouches
• B29K 27/06 - PVC, c.-à-d. polychlorure de vinyle
• B29K 27/12 - Utilisation de polyhalogénures de vinyle comme matière de moulage contenant du fluor
• B29K 105/00 - Présentation, forme ou état de la matière moulée
• B29L 9/00 - Produits stratifiés
• B29L 31/00 - Autres objets particuliers
• B65B 9/04 - Enserrage d'objets les uns à la suite des autres ou de quantités de matériaux, entre bandes se faisant face une bande ou bien les deux comportant des poches pour recevoir les objets ou des quantités de matériaux
• B65B 11/52 - Enserrage d'objets ou de quantités de matériau en plaçant le contenu entre deux feuilles, p. ex. des feuilles comportant des poches, et en fixant ensemble leurs bords libres opposés une des feuilles étant rendue plastique, p. ex. par chauffage, et forcée par la pression exercée par un fluide, p. ex. à l'aide du vide, à s'engager avec l'autre feuille et avec le contenu, p. ex. emballage sous peau
• B65B 47/02 - Appareils ou dispositifs pour former des poches ou des récipients dans ou à partir de feuilles, flans ou bandes, comprenant essentiellement une matrice dans laquelle le matériau est pressé ou une matrice de pliage à travers laquelle le matériau se déplace avec des moyens pour chauffer le matériau avant le formage
• B65B 51/10 - Application ou production de chaleur ou de pression ou les deux à la fois
• B65D 6/00 - Réceptacles dont le corps est formé par jonction ou liaison de plusieurs composants rigides ou sensiblement rigides, constitués en totalité ou principalement en métal, en matière plastique, en bois ou en un matériau de remplacement
• B65D 75/32 - Objets ou matériaux enveloppés entre deux feuilles ou flans opposés à bords réunis, p. ex. par adhésifs à pression, pliage, thermosoudage ou soudage une ou les deux feuilles ou flans étant renfoncés pour épouser la forme du contenu
• B65D 83/04 - Réceptacles ou paquets comportant des moyens particuliers pour distribuer leur contenu pour distribuer de petits objets en forme d'anneau, de disque, de sphère ou similaire, p. ex. des comprimés ou des pilules

Abrégé

Disclosed herein are pharmaceutical compositions and methods for the treatment and prophylaxis of bacterial infections of the skin, including, topical ulcers caused by Mycobacterium ulcerans in Buruli ulcers, and/or other topical infections and types of inflammation. In particular, the compositions comprise clofazimine, derivatives thereof, polymorphs thereof, and/or analogs thereof in a solution, suspension, creams, oils, emulsions, and ointments for topical application. Methods for making the compositions are also disclosed.

Classes IPC  ?

• A61K 31/498 - Pyrazines ou pipérazines condensées en ortho ou en péri avec des systèmes carbocycliques, p. ex. quinoxaline, phénazine
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 9/107 - Émulsions
• A61K 47/12 - Acides carboxyliquesLeurs sels ou anhydrides
• A61K 47/24 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant des atomes autres que des atomes de carbone, d'hydrogène, d'oxygène, d'halogènes, d'azote ou de soufre, p. ex. cyclométhicone ou phospholipides
• A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine

Abrégé

A method for treating obesity associated with Prader Willi Syndrome is disclosed.

Classes IPC  ?

• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 31/198 - Alpha-amino-acides, p. ex. alanine ou acide édétique [EDTA]
• A61K 31/495 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec deux azote comme seuls hétéro-atomes d'un cycle, p. ex. pipérazine
• A61K 38/28 - Insulines
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur

Produits et services

Pharmaceutical preparations for the treatment of diabetes, endocrine diseases and disorders, metabolic diseases and disorders; pharmaceutical preparations for inhalation for the treatment of lung diseases and disorders, including, pulmonary arterial hypertension and interstitial lung diseases, including, idiopathic pulmonary fibrosis, and lung infections, including, mycobacterial infections. Medical devices, namely, devices for the administration of pharmaceuticals for inhalation for the treatment of lung diseases and disorders, including pulmonary arterial hypertension and interstitial lung diseases, including, idiopathic pulmonary fibrosis, and lung infections, including, mycobacterial infections; medical devices, namely, devices for the administration of pharmaceuticals for the treatment of diabetes, endocrine diseases and disorders, metabolic diseases and disorders.

Produits et services

Pharmaceutical preparations for the treatment of diabetes, endocrine diseases and disorders, metabolic diseases and disorders; pharmaceutical preparations for inhalation for the treatment of lung diseases and disorders, including, pulmonary arterial hypertension and interstitial lung diseases, including, idiopathic pulmonary fibrosis, and lung infections, including, mycobacterial infections. Medical devices, namely, devices for the administration of pharmaceuticals for inhalation for the treatment of lung diseases and disorders, including pulmonary arterial hypertension and interstitial lung diseases, including, idiopathic pulmonary fibrosis, and lung infections, including, mycobacterial infections; medical devices, namely, devices for the administration of pharmaceuticals for the treatment of diabetes, endocrine diseases and disorders, metabolic diseases and disorders.

Produits et services

Pharmaceutical preparations for inhalation for the treatment of lung infections, including, mycobacterial infections. Medical devices, namely, devices for the administration of pharmaceuticals for inhalation for the treatment of lung infections, including, mycobacterial infections.

Abrégé

An ultra-rapid acting insulin composition and method for treating hyperglycemia in patients with diabetes are disclose. The composition is an inhalable dry powder composition comprising fumaryl diketopiperazine and insulin for pulmonary delivery, which significantly reduces the rates of hypoglycemic events in patients in patients on mealtime insulin therapy.

Classes IPC  ?

• A61K 38/28 - Insulines
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique

Abrégé

A method for the synthesis of N-protected 3,6-aminoalkyl-2,5-diketopiperazines is provided. The method includes obtaining a cyclic α-N protected active amino ester and adding it to a mixture of an amine catalyst in an organic solvent.

Classes IPC  ?

• C07D 241/08 - Composés hétérocycliques contenant des cycles diazine-1,4 ou diazine-1,4 hydrogéné non condensés avec d'autres cycles comportant une ou deux liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec des atomes d'oxygène liés directement aux atomes de carbone du cycle
• C07D 241/04 - Composés hétérocycliques contenant des cycles diazine-1,4 ou diazine-1,4 hydrogéné non condensés avec d'autres cycles ne comportant pas de liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques
• C07D 241/10 - Composés hétérocycliques contenant des cycles diazine-1,4 ou diazine-1,4 hydrogéné non condensés avec d'autres cycles comportant trois liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques

Abrégé

An adapter (650) for transferring fluid between a first device (100) and a second device (800). The adapter comprises a first end (652) for receiving the first device, wherein the first end includes a side wall for locating around the first device (100). The adapter (650) further comprises a second end (654) for engaging the first device (100), and including a retaining member (656;658;662), wherein the retaining member (656;658;662) is operable to prevent removal of the first device (100) from the adapter (650) upon engagement of the first device (100) with the second end (654). The first end (652) and the second end (654) are open on both ends to comprise a through-bore extending through the adapter (650). In some cases, the first device (100) may be a drug pen containing insulin.

Classes IPC  ?

• A61J 1/20 - Dispositions pour le transfert des liquides, p. ex. du flacon à la seringue
• A61J 1/14 - Récipients spécialement adaptés à des fins médicales ou pharmaceutiques DétailsAccessoires à cet effet

Produits et services

(1) Pharmaceutical preparations for the treatment of diabetes, endocrine diseases and disorders, metabolic diseases and disorders; pharmaceutical preparations for inhalation for the treatment of lung diseases and disorders, including, pulmonary arterial hypertension and interstitial lung diseases, including, idiopathic pulmonary fibrosis, and lung infections, including, mycobacterial infections. (2) Medical devices, namely, devices for the administration of pharmaceuticals for inhalation for the treatment of lung diseases and disorders, including pulmonary arterial hypertension and interstitial lung diseases, including, idiopathic pulmonary fibrosis, and lung infections, including, mycobacterial infections; medical devices, namely, devices for the administration of pharmaceuticals for the treatment of diabetes, endocrine diseases and disorders, metabolic diseases and disorders.

Produits et services

(1) Pharmaceutical preparations for inhalation for the treatment of lung infections, including, mycobacterial infections. (2) Medical devices, namely, devices for the administration of pharmaceuticals for inhalation for the treatment of lung infections, including, mycobacterial infections.

Produits et services

Medical information services, namely, providing a website in the medical, pharmaceutical and health fields featuring information related to health, wellness, healthcare, patient support services, pharmaceuticals, pharmaceutical access, drug safety and drug compatibility in relation to therapy and treatment of individuals, adherence to pharmaceutical treatment protocols, and the diagnostic, prophylactic and therapeutic properties of pharmaceuticals; Medical care consulting services in the fields of diagnostics, patient treatment and treatment protocols; Prescription reminder service for reminding patients of pharmaceutical preparation, dosage, allergic sensitivity, and refills for medical treatment purposes; Medical services in the nature of providing medical advice in the field of pharmaceutical use, patient health and treatment services; Medical services in the nature of providing information on health, wellness, healthcare, patient support services, pharmaceuticals, pharmaceutical access, drug safety and drug compatibility relating to therapy and the diagnostic, prophylactic and therapeutic properties of pharmaceuticals

Abrégé

A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin, oxyntomodulin and glucagon-like peptide.

Classes IPC  ?

• A61M 15/00 - Inhalateurs
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 38/00 - Préparations médicinales contenant des peptides
• A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
• A61K 38/22 - Hormones
• A61K 38/26 - Glucagons
• A61K 38/28 - Insulines
• A61K 47/22 - Composés hétérocycliques, p. ex. acide ascorbique, tocophérol ou pyrrolidones

Abrégé

A fluid delivery device comprises a drive unit including an actuator and one or more first features and a cartridge filled with a fluid prior to being inserted into the housing. The cartridge having a fluid reservoir sealed at one end by a movable piston and sealed at another end by a pierceable septum. The cartridge includes one or more second features that are configured to align and mate with the one or more first features allowing the cartridge to be inserted into the drive unit. The piston is moveabe by the actuator once the cartridge is inserted into the drive unit.

Classes IPC  ?

• A61M 5/142 - Perfusion sous pression, p. ex. utilisant des pompes
• A61M 5/145 - Perfusion sous pression, p. ex. utilisant des pompes utilisant des réservoirs sous pression, p. ex. au moyen de pistons
• A61M 5/28 - Ampoules ou cartouches-seringues, c.-à-d. ampoules ou cartouches munies d'une aiguille

Produits et services

Pharmaceutical preparations, namely, pharmaceutical preparations for the treatment of diabetes, endocrine diseases and disorders, metabolic diseases and disorders; pharmaceutical preparations containing insulin for the treatment of diabetes, endocrine diseases and disorders, metabolic diseases and disorders; inhaler systems, comprised of inhalers and cartridges, both filled with pharmaceutical preparations for the treatment of diabetes, endocrine diseases and disorders, metabolic diseases and disorders

Abrégé

A method of introducing a physiologically-active agent into the circulatory system of a mammal is disclosed herein. The method utilizes a rapid drug delivery system which prevents deactivation or degradation of the active agent being administered to a patient in need of treatment. In particular, the drug delivery system is designed for pulmonary drug delivery such as by inhalation, for delivery of the active agents such as proteins and peptides to the pulmonary circulation in a therapeutically effective manner avoiding degradation of the active agents in peripheral and vascular tissue before reaching the target site.

Classes IPC  ?

• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 9/16 - AgglomérésGranulésMicrobilles
• A61K 31/495 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec deux azote comme seuls hétéro-atomes d'un cycle, p. ex. pipérazine
• A61K 38/26 - Glucagons

Abrégé

Disclosed herein are improved methods of treating hyperglycemia with a combination of an ultrarapid acting insulin and insulin glargine comprising prandial administration of the ultrarapid insulin, and administration of a first dose of insulin glargine within 6 hours of waking for a day.

Classes IPC  ?

• A61K 38/28 - Insulines
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique

Produits et services

Medical apparatus, namely, infusion and injection devices for administering drugs. Medical services; medical services in the field of diabetes; medical services in the nature of patient support relating to the treatment of diabetes; medical information services, namely, providing information relating to the treatment of diabetes.

Abrégé

Inhalable compositions for treating pulmonary hypertension comprising treprostinil, derivative thereof or analogs thereof and a method for treating pulmonary arterial hypertension and/or idiopathic pulmonary fibrosis are disclosed herein. Methods of manufacturing pharmaceutical compositions are also disclosed. Compositions are based on diketopiperazine powders for pulmonary inhalation.

Classes IPC  ?

• A61K 31/495 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec deux azote comme seuls hétéro-atomes d'un cycle, p. ex. pipérazine
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 31/191 - Acides acycliques ayant plusieurs groupes hydroxyle, p. ex. acide gluconique
• A61P 9/12 - Antihypertenseurs

Abrégé

Disclosed herein are improved methods of treating hyperglycemia with a combination of an ultrarapid acting insulin and insulin glargine comprising prandial administration of the ultrarapid insulin, and administration of a first dose of insulin glargine within 6 hours of waking for a day.

Classes IPC  ?

• A61K 38/28 - Insulines
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 31/155 - Amidines (), p. ex. guanidine (H2N-C(=NH)-NH2), isourée (HN=C(OH)NH2), isothiourée (HN=C(SH)-NH2)

Abrégé

A fluid delivery device comprises a housing having a fluid reservoir. A needle is in fluid communication with the fluid reservoir in an engaged position and out of fluid communication with the fluid reservoir in armed and storage positions. A proximal end of a biasing member is coupled to the housing and a distal end of the biasing member is configured to deliver a force to the fluid reservoir. A piston member extends through the biasing member and is coupled to the distal end of the biasing member. The piston member is fixed with respect to the housing in a locked position such that the biasing member does not deliver the force to the fluid reservoir and moveable with respect to the housing in a released position such that the biasing member delivers the force to the fluid reservoir. Transitioning the needle from the storage position to the armed position transitions the piston from the locked position to the released position.

Classes IPC  ?

• A61M 5/142 - Perfusion sous pression, p. ex. utilisant des pompes
• A61M 5/145 - Perfusion sous pression, p. ex. utilisant des pompes utilisant des réservoirs sous pression, p. ex. au moyen de pistons
• A61M 5/162 - Raccords à aiguilles, c.-à-d. raccordements par perforation entre le réservoir et le tube
• A61M 5/168 - Moyens pour commander l'écoulement des agents vers le corps ou pour doser les agents à introduire dans le corps, p. ex. compteurs de goutte-à-goutte

Produits et services

(1) Scientific and medical research and development in the fields of pharmaceuticals; Scientific and medical research and development in the fields of medical devices and medical technology used in connection with the delivery of pharmaceuticals via inhalation; Product design and development for others in the field of drug delivery systems, medical devices, and medical technology used in connection with the delivery of pharmaceuticals via inhalation. (2) Licensing to others of technology, namely, licensing of technologies related to drug formulations and medical devices used in connection with the delivery of pharmaceuticals via inhalation; Licensing to others intellectual property related to drug formulations and medical devices used in connection with the delivery of pharmaceuticals via inhalation.

Produits et services

Scientific and medical research and development in the fields of pharmaceuticals; Scientific and medical research and development in the fields of medical devices and medical technology used in connection with the delivery of pharmaceuticals via inhalation; Product design and development for others in the field of drug delivery systems, medical devices, and medical technology used in connection with the delivery of pharmaceuticals via inhalation. Licensing to others of technology, namely, licensing of technologies related to drug formulations and medical devices used in connection with the delivery of pharmaceuticals via inhalation; Licensing to others intellectual property related to drug formulations and medical devices used in connection with the delivery of pharmaceuticals via inhalation.

Abrégé

Cryogranulation systems with improved dispenser assemblies are provided for use in manufacturing frozen pellets of pharmaceutical substances in a fluid medium. Methods of cryogranulating the pharmaceutical substance in the fluid medium are also provided. In particular embodiments, the dispenser assembly is used with suspensions or slurries of pharmaceutical compositions including biodegradable substances, such as proteins, peptides, and nucleic acids. In certain embodiments, the pharmaceutical substance can be adsorbed to any pharmaceutically acceptable carrier particles suitable for making pharmaceutical powders. In one embodiment, the pharmaceutical carrier can be, for example, diketopiperazine-based microparticles. The dispenser assembly improves the physical characteristics of the cryopellets formed and minimizes product loss during processing.

Classes IPC  ?

• A61K 9/16 - AgglomérésGranulésMicrobilles
• A61J 3/00 - Dispositifs ou procédés spécialement conçus pour donner à des produits pharmaceutiques une forme physique déterminée ou une forme propre à leur administration
• A61K 38/28 - Insulines
• B01J 2/06 - Procédés ou dispositifs pour la granulation de substances, en généralTraitement de matériaux particulaires leur permettant de s'écouler librement, en général, p. ex. en les rendant hydrophobes par division du produit liquide en gouttelettes, p. ex. par pulvérisation, et solidification des gouttelettes en milieu liquide

Produits et services

Pharmaceutical preparations for inhalation for the treatment of lung infections, including, mycobacterial infections Medical devices, namely, devices for the administration of pharmaceuticals for inhalation for the treatment of lung infections, including, mycobacterial infections

Produits et services

Pharmaceutical preparations for the treatment of diabetes, endocrine diseases and disorders, metabolic diseases and disorders; Pharmaceutical preparations for inhalation for the treatment of lung diseases and disorders, including, pulmonary arterial hypertension and interstitial lung diseases, including, idiopathic pulmonary fibrosis, and lung infections, including, mycobacterial infections Medical devices, namely, devices for the administration of pharmaceuticals for inhalation for the treatment of lung diseases and disorders, including pulmonary arterial hypertension and interstitial lung diseases, including, idiopathic pulmonary fibrosis, and lung infections, including, mycobacterial infections; Medical devices, namely, devices for the administration of pharmaceuticals for the treatment of diabetes, endocrine diseases and disorders, metabolic diseases and disorders

Abrégé

Provided are novel treprostinil based compounds, methods of treatment using the same, and their methods of making.

Classes IPC  ?

• A61K 31/192 - Acides carboxyliques, p. ex. acide valproïque ayant des groupes aromatiques, p. ex. sulindac, acides 2-aryl-propioniques, acide éthacrynique
• A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique

Abrégé

A method, composition and kit for the treatment of fibrotic lung disease are disclosed. The method utilizes a combination product for inhalation comprising a therapeutic amount of a dry powder formulation provided in an inhaler to be administered to a subject in need by oral inhalation. The composition comprise diketopiperazine particles for pulmonary inhalation.

Classes IPC  ?

• A61K 9/16 - AgglomérésGranulésMicrobilles
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 31/4412 - Pyridines non condenséesLeurs dérivés hydrogénés ayant des groupes oxo liés directement à l'hétérocycle
• A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p. ex. rifampine, thiothixène ou sparfloxacine

Abrégé

The present invention relates to pharmaceutical compositions for inhalation comprising a therapeutically effective dose of clofazimine wherein the clofazimine is provided in the form of a suspension, and processes for their preparation. Furthermore, the present invention provides pharmaceutical combinations comprising clofazimine in the form of an aerosol for pulmonary inhalation. The combinations and compositions provided by the present invention may be used in the treatment and/or prophylaxis of pulmonary infections caused by mycobacteria and other gram-positive bacteria, and of pulmonary fungal infections.

Classes IPC  ?

• A61K 31/498 - Pyrazines ou pipérazines condensées en ortho ou en péri avec des systèmes carbocycliques, p. ex. quinoxaline, phénazine
• A61K 9/10 - DispersionsÉmulsions
• A61K 31/47 - QuinoléinesIsoquinoléines
• A61K 47/02 - Composés inorganiques
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine

Abrégé

Described herein are interactive apparatus and methods for sensing and measuring real-time characteristic patterns of a subject's use of a dry powder inhalation system. The devices can be used in a wired or wireless communication mode to communicate with a display to assess the subject's usage of the inhalation system, to evaluate the performance of the inhalation system and/or to detect the characteristics profile of a dry powder formulation emitted from the inhalation system in use.

Classes IPC  ?

• A61M 15/00 - Inhalateurs
• A61B 5/087 - Mesure du débit respiratoire
• G09B 23/28 - Modèles à usage scientifique, médical ou mathématique, p. ex. dispositif en vraie grandeur pour la démonstration pour la médecine

Produits et services

Medical information services, including providing medical, pharmaceutical and health information related to health, wellness, healthcare, patient support services, pharmaceuticals, pharmaceutical access, drug safety and/or drug compatibility in relation to therapy and treatment of individuals, adherence to pharmaceutical protocols, and the diagnostic, prophylactic and therapeutic properties of pharmaceuticals via a website; medical care consulting services in the fields of diagnostics, patient treatment and treatment protocols.

Abrégé

Methods are provided for drying a particle. Specifically, there is provided a spray-dried diketopiperazine-insulin particle formulation having improved aerodynamic performance and in which the active agent is more stabile and efficiently delivered as compared to that of the lyophilized diketopiperazine-insulin formulation. The dry powders have utility as pharmaceutical formulations for pulmonary delivery.

Classes IPC  ?

• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 9/14 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres
• A61K 9/16 - AgglomérésGranulésMicrobilles
• A61K 38/28 - Insulines

Produits et services

Providing a database featuring information about patient reimbursement and insurance coverage for pharmaceuticals and medical devices; insurance consultation services, namely, assisting physician offices and patients to identify the scope of coverage offered by patient medical and pharmaceutical insurance; insurance benefits verification services in the medical field; insurance consultation services, namely, assisting physician offices and patients to obtain prior authorization for medical and pharmaceutical insurance claims and the preparation and submission of related paperwork and assisting physician offices and patients to appeal denial of medical and pharmaceutical insurance claims and the preparation and submission of related paperwork Providing temporary use of online non-downloadable software that assists patients with the filling and delivery of pharmaceutical prescriptions through communication with patient pharmacies Medical information services, namely, providing a website in the medical, pharmaceutical and health fields featuring information related to health, wellness, healthcare, patient support services, pharmaceuticals, pharmaceutical access, drug safety and drug compatibility in relation to therapy and treatment of individuals, adherence to pharmaceutical protocols, and the diagnostic, prophylactic and therapeutic properties of pharmaceuticals; medical care consulting services in the fields of diagnostics, patient treatment and treatment protocols; prescription reminder service for reminding patients of pharmaceutical preparation, dosage, allergic sensitivity, and refills for medical treatment purposes; medical services in the nature of providing medical advice in the field of pharmaceutical use, patient health and treatment services; medical services in the nature of providing information on health, wellness, healthcare, patient support services, pharmaceuticals, pharmaceutical access, drug safety and drug compatibility relating to therapy and the diagnostic, prophylactic and therapeutic properties of pharmaceuticals

Abrégé

Methods are provided for promoting the adsorption of an active agent to microparticles by modifying the structural properties of the active agent in order to facilitate favorable association to the microparticle.

Classes IPC  ?

• A61K 9/16 - AgglomérésGranulésMicrobilles
• A61K 38/13 - Cyclosporines
• A61K 38/25 - Facteur libérant l'hormone de croissance [GH-RF], c.-à-d. somatolibérine
• A61K 38/27 - Hormone de croissance [GH], c.-à-d. somatotropine
• A61K 38/28 - Insulines
• A61K 38/29 - Hormone parathyroïdienne, c.-à-d. parathormonePeptides dérivés de l'hormone parathyroïdienne
• A61K 9/50 - Microcapsules
• A61K 38/22 - Hormones
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 38/26 - Glucagons

Abrégé

A method, composition and kit for the treatment of fibrotic lung disease are disclosed. The method utilizes a combination product for inhalation comprising a therapeutic amount of a dry powder formulation provided in an inhaler to be administered to a subject in need by oral inhalation. The composition comprises diketopiperazine particles and a kinase inhibitor for oral inhalation.

Classes IPC  ?

• A61K 9/14 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres
• A61K 31/4439 - Pyridines non condenséesLeurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p. ex. oméprazole
• C07D 213/04 - Composés hétérocycliques contenant des cycles à six chaînons, non condensés avec d'autres cycles, ne comportant qu'un atome d'azote comme unique hétéro-atome du cycle et avec au moins trois doubles liaisons entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques comportant trois liaisons doubles ne comportant pas de liaison entre l'atome d'azote du cycle et un chaînon non cyclique ou ne comportant que des atomes d'hydrogène ou de carbone liés directement à l'atome d'azote du cycle
• C07D 231/14 - Composés hétérocycliques contenant des cycles diazole-1, 2 ou diazole-1, 2 hydrogéné non condensés avec d'autres cycles comportant deux ou trois liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec des hétéro-atomes ou avec des atomes de carbone comportant trois liaisons à des hétéro-atomes, avec au plus une liaison à un halogène, p. ex. radicaux ester ou nitrile, liés directement aux atomes de carbone du cycle
• C07D 241/02 - Composés hétérocycliques contenant des cycles diazine-1,4 ou diazine-1,4 hydrogéné non condensés avec d'autres cycles
• C07D 495/04 - Systèmes condensés en ortho

Produits et services

Medical apparatus, namely, infusion and injection devices for administering drugs Medical services; Medical services in the field of diabetes; Medical services in the nature of patient support relating to the treatment of diabetes; Medical information services, namely, providing information relating to the treatment of diabetes

Abrégé

A medicament delivery device may comprise a medicament chamber configured to hold a medicament, a plunger configured to move relative to the medicament chamber to expel the medicament from the medicament chamber, a pin configured to move from a first pin position wherein the pin prevents movement of the plunger to a second pin position wherein the pin allows movement of the plunger, an actuation assembly configured to move the pin from the first pin position to the second pin position, and a needle coupled to the medicament chamber. The medicament may flow through the needle from the medicament chamber to a user. The actuation assembly may be configured to automatically move the pin after a predetermined time delay.

Classes IPC  ?

• A61M 5/142 - Perfusion sous pression, p. ex. utilisant des pompes
• A61M 5/145 - Perfusion sous pression, p. ex. utilisant des pompes utilisant des réservoirs sous pression, p. ex. au moyen de pistons
• A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles

Abrégé

A medicament delivery assembly comprises a delivery device configured to deliver medicament to a user, a communication accessory releasably coupled to the delivery device, and one or more sensors configured to sense a condition of the delivery device. The communication accessory may be configured to receive a first signal from the one or more sensors assembly and to send a second signal to an external device.

Classes IPC  ?

• A61M 5/315 - PistonsTiges de pistonGuidage, blocage, ou limitation des mouvements de la tigeAccessoires disposés sur la tige pour faciliter le dosage
• G16H 20/17 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p. ex. pour s’assurer de l’administration correcte aux patients administrés par perfusion ou injection
• A61M 5/31 - Seringues Parties constitutives

Produits et services

Scientific and medical research and development in the fields of pharmaceuticals; Scientific and medical research and development in the fields of medical devices and medical technology used in connection with the delivery of pharmaceuticals via inhalation; Product design and development for others in the field of drug delivery systems, medical devices, and medical technology used in connection with the delivery of pharmaceuticals via inhalation Licensing to others of technology, namely, licensing of technologies related to drug formulations and medical devices used in connection with the delivery of pharmaceuticals via inhalation; Licensing to others intellectual property related to drug formulations and medical devices used in connection with the delivery of pharmaceuticals via inhalation

Abrégé

A method of treating a patient with diabetes is provided. The method includes determining a number of powdered insulin units required for each different meal in a day, rounding the number of powdered insulin units up to a nearest predetermined powdered insulin dose for each of the different meals, determining a number and capacity of powdered insulin cartridges to achieve the nearest predetermined powdered insulin doses for each of the different meals, multiplying the number of powdered insulin cartridges of each capacity for each different meal by a number of the different meals in a prescription period, determining a number of boxes of powdered insulin cartridges of each capacity for the prescription period, and prescribing the determined number of boxes of powdered insulin cartridges of each capacity.

Classes IPC  ?

• G16H 20/10 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p. ex. pour s’assurer de l’administration correcte aux patients
• G16H 20/13 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p. ex. pour s’assurer de l’administration correcte aux patients delivrés par des distributeurs
• G16H 40/60 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux

Abrégé

A fluid delivery device comprises a fluid reservoir for containing medicament. The fluid reservoir is sealed proximate one end with a sliding seal piston. A delivery path is configured to fluidly couple the fluid reservoir and a patient wearing the fluid delivery device. A basal engine mechanism is configured to directly or indirectly move the sliding seal piston in the fluid reservoir at a controlled basal rate. A bolus mechanism configured to move the basal engine relative to the fluid reservoir and directly or indirectly move the sliding seal piston in the fluid reservoir a discrete bolus amount at a time.

Classes IPC  ?

• A61M 5/145 - Perfusion sous pression, p. ex. utilisant des pompes utilisant des réservoirs sous pression, p. ex. au moyen de pistons
• A61M 5/315 - PistonsTiges de pistonGuidage, blocage, ou limitation des mouvements de la tigeAccessoires disposés sur la tige pour faciliter le dosage
• A61M 5/142 - Perfusion sous pression, p. ex. utilisant des pompes

Abrégé

Disclosed herein are methods of treatment and/or prophylaxis of viral infections. In particular, the method is for the administration by inhalation of a pharmaceutically effective dose of clofazimine, which is provided in the form of a solution, suspension, or as a dry powder, in formulations suitable for inhalation.

Classes IPC  ?

• A61K 31/498 - Pyrazines ou pipérazines condensées en ortho ou en péri avec des systèmes carbocycliques, p. ex. quinoxaline, phénazine
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
• A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
• A61K 47/12 - Acides carboxyliquesLeurs sels ou anhydrides

Abrégé

A fluid delivery device includes a housing having a bottom surface configured to be coupled to the skin surface. The fluid delivery device includes a cartridge prefilled with a fluid and configured to be inserted into the housing. The cartridge has a septum configured to be generally perpendicular to the bottom surface when the cartridge is inserted in the housing. The fluid delivery device includes a needle assembly that has a needle that includes a fluid coupling end and a delivery end. The fluid coupling end of the needle is fluidly disengaged from the cartridge in an initial position. The delivery end of the needle extends past the plane of the bottom surface and the fluid coupling end of the needle extends through the septum in a deployed position.

Classes IPC  ?

• A61M 5/142 - Perfusion sous pression, p. ex. utilisant des pompes
• A61M 5/14 - Dispositifs de perfusion, p. ex. perfusion par gravitéPerfusion sanguineAccessoires à cet effet
• A61M 5/145 - Perfusion sous pression, p. ex. utilisant des pompes utilisant des réservoirs sous pression, p. ex. au moyen de pistons
• A61M 5/158 - Aiguilles
• A61M 5/162 - Raccords à aiguilles, c.-à-d. raccordements par perforation entre le réservoir et le tube
• A61M 5/28 - Ampoules ou cartouches-seringues, c.-à-d. ampoules ou cartouches munies d'une aiguille

Abrégé

A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, with or without a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, small organic molecules, peptides and proteins, including, hormones such as insulin and glucagon-like peptide 1 for the treatment of disease and disorders, for example, diseases and disorders, including endocrine disease such as diabetes and/or obesity.

Classes IPC  ?

• A61M 15/00 - Inhalateurs
• A61M 11/00 - Pulvérisateurs ou vaporisateurs spécialement destinés à des usages médicaux
• A61M 16/00 - Dispositifs pour agir sur le système respiratoire des patients par un traitement au gaz, p. ex. ventilateursTubes trachéaux

Abrégé

Disclosed herein are diketopiperazine microparticles having a specific surface area of less than about 67 m2/g. The diketopiperazine microparticle can be fumaryl diketopiperazine and can comprise a drug such as insulin.

Classes IPC  ?

• A61K 31/495 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec deux azote comme seuls hétéro-atomes d'un cycle, p. ex. pipérazine
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 9/16 - AgglomérésGranulésMicrobilles
• A61K 9/19 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres lyophilisées
• A61K 9/14 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres
• A61K 38/28 - Insulines
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
• A61M 15/00 - Inhalateurs
• C07D 241/08 - Composés hétérocycliques contenant des cycles diazine-1,4 ou diazine-1,4 hydrogéné non condensés avec d'autres cycles comportant une ou deux liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec des atomes d'oxygène liés directement aux atomes de carbone du cycle
• A61K 31/5575 - Eicosanoïdes, p. ex. leucotriènes ayant un cycle cyclopentane, p. ex. prostaglandine E2, prostaglandine F2-alpha
• A61K 38/19 - CytokinesLymphokinesInterférons

Abrégé

Mycobacterium ulceransMycobacterium ulcerans in Buruli ulcers, and/or other topical infections and types of inflammation. In particular, the compositions comprise clofazimine, derivatives thereof, polymorphs thereof, and/or analogs thereof in a solution, suspension, creams, oils, emulsions, and ointments for topical application. Methods for making the compositions are also disclosed.

Classes IPC  ?

• A61K 31/33 - Composés hétérocycliques
• A61K 31/395 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines
• A61K 31/435 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle

Produits et services

Pharmaceutical preparations, namely, pharmaceutical preparations for the treatment of diabetes, endocrine diseases and disorders, metabolic diseases and disorders; pharmaceutical preparations containing insulin for the treatment and prevention of diabetes Medical devices, namely, inhalers for medical use, cartridges for medical use, and inhaler systems comprised of inhalers and cartridges for medical use for the inhalation of pharmaceuticals, all provided empty; Medical devices for use as a component of inhaler systems for medical use, namely, devices used to measure patient inhalation effort and to indicate dosing of medication, all provided empty and used for the inhalation of pharmaceuticals

Abrégé

Dry powder inhaler systems for pulmonary delivery of pharmaceuticals are disclosed.

Classes IPC  ?

• A61M 15/00 - Inhalateurs

Abrégé

Disclosed herein are improved methods of treating hyperglycemia with a combination of an ultrarapid acting insulin and insulin glargine comprising prandial administration of the ultrarapid insulin, and administration of a first dose of insulin glargine within 6 hours of waking for a day.

Classes IPC  ?

• A61K 38/28 - Insulines
• A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier

Abrégé

Inhalable compositions for treating pulmonary hypertension comprising treprostinil, derivative thereof or analogs thereof and a method for treating pulmonary hypertension, pulmonary arterial hypertension and/or idiopathic pulmonary fibrosis are disclosed herein. Methods of manufacturing pharmaceutical compositions are also disclosed. Pharmaceutical compositions are based on crystalline diketopiperazine dry powders for pulmonary inhalation.

Classes IPC  ?

• A61K 9/14 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres
• A61K 9/19 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres lyophilisées
• A61K 31/216 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides carboxyliques d'acides ayant des cycles aromatiques, p. ex. bénactizyne, clofibrate
• A61K 31/5575 - Eicosanoïdes, p. ex. leucotriènes ayant un cycle cyclopentane, p. ex. prostaglandine E2, prostaglandine F2-alpha
• A61M 15/00 - Inhalateurs
• A61P 11/00 - Médicaments pour le traitement des troubles du système respiratoire

Abrégé

Inhalable compositions for treating pulmonary hypertension comprising treprostinil, derivative thereof or analogs thereof and a method for treating pulmonary hypertension, pulmonary arterial hypertension and/or idiopathic pulmonary fibrosis are disclosed herein. Methods of manufacturing pharmaceutical compositions are also disclosed. Pharmaceutical compositions are based on crystalline diketopiperazine dry powders for pulmonary inhalation.

Classes IPC  ?

• A61K 9/14 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres
• A61K 9/19 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres lyophilisées
• A61K 31/216 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides carboxyliques d'acides ayant des cycles aromatiques, p. ex. bénactizyne, clofibrate
• A61K 31/5575 - Eicosanoïdes, p. ex. leucotriènes ayant un cycle cyclopentane, p. ex. prostaglandine E2, prostaglandine F2-alpha
• A61M 15/00 - Inhalateurs
• A61P 11/00 - Médicaments pour le traitement des troubles du système respiratoire

Abrégé

Inhalable compositions for treating pulmonary hypertension comprising treprostinil, derivative thereof or analogs thereof and a method for treating pulmonary arterial hypertension and/or idiopathic pulmonary fibrosis are disclosed herein. Methods of manufacturing pharmaceutical compositions are also disclosed. Compositions are based on diketopiperazine powders for pulmonary inhalation.

Classes IPC  ?

• A61K 31/495 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec deux azote comme seuls hétéro-atomes d'un cycle, p. ex. pipérazine
• A61K 31/191 - Acides acycliques ayant plusieurs groupes hydroxyle, p. ex. acide gluconique
• A61P 9/12 - Antihypertenseurs
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier

Produits et services

(1) Pharmaceutical preparations, namely, pharmaceutical preparations for the treatment of diabetes, endocrine diseases and disorders; pharmaceutical preparations containing insulin; pharmaceutical preparations for the treatment of metabolic diseases and disorders, lung diseases and disorders, including, pulmonary arterial hypertension, interstitial lung diseases and pulmonary fibrosis (2) Medical devices, namely, inhalers, cartridges, and inhaler systems comprising inhalers and cartridges for administration of pharmaceuticals, all provided empty; medical devices, namely, instruments and apparatus provided empty used for the inhalation of pharmaceuticals (1) Medical information services, namely, providing a website in the medical, pharmaceutical and health fields featuring information related to health, wellness, healthcare, patient support services, pharmaceuticals, pharmaceutical access, drug safety and drug compatibility in relation to therapy and treatment of individuals, adherence to pharmaceutical protocols, and the diagnostic, prophylactic and therapeutic properties of pharmaceuticals; medical care consulting services in the fields of diagnostics, patient treatment and treatment protocols; prescription reminder service for reminding patients of pharmaceutical preparation, dosage, allergic sensitivity, and refills for medical treatment purposes; medical services in the nature of providing medical advice in the field of pharmaceutical use, patient health and treatment services; medical services in the nature of providing information on health, wellness, healthcare, patient support services, pharmaceuticals, pharmaceutical access, drug safety and drug compatibility relating to therapy and the diagnostic, prophylactic and therapeutic properties of pharmaceuticals

Produits et services

(1) Pharmaceutical preparations, namely, pharmaceutical preparations for the treatment of diabetes, endocrine diseases and disorders; pharmaceutical preparations containing insulin; pharmaceutical preparations for the treatment of metabolic diseases and disorders, lung diseases and disorders, including, pulmonary arterial hypertension, interstitial lung diseases and pulmonary fibrosis (2) Medical devices, namely, inhalers, cartridges, and inhaler systems comprising inhalers and cartridges for administration of pharmaceuticals, all provided empty; medical devices, namely, instruments and apparatus provided empty used for the inhalation of pharmaceuticals (1) Medical information services, namely, providing a website in the medical, pharmaceutical and health fields featuring information related to health, wellness, healthcare, patient support services, pharmaceuticals, pharmaceutical access, drug safety and drug compatibility in relation to therapy and treatment of individuals, adherence to pharmaceutical protocols, and the diagnostic, prophylactic and therapeutic properties of pharmaceuticals; medical care consulting services in the fields of diagnostics, patient treatment and treatment protocols; prescription reminder service for reminding patients of pharmaceutical preparation, dosage, allergic sensitivity, and refills for medical treatment purposes; medical services in the nature of providing medical advice in the field of pharmaceutical use, patient health and treatment services; medical services in the nature of providing information on health, wellness, healthcare, patient support services, pharmaceuticals, pharmaceutical access, drug safety and drug compatibility relating to therapy and the diagnostic, prophylactic and therapeutic properties of pharmaceuticals

Produits et services

(1) Licensing to others of technology and intellectual property in connection with medical devices

Produits et services

Licensing to others of technology and intellectual property in connection with medical devices.

Abrégé

A dry powder inhaler including replaceable cartridges containing a dry powder for local or systemic delivery through the pulmonary tract and lungs is disclosed. The inhalers are used with inhalable dry powders, including medicament formulations comprising active agents for local or systemic delivery and for the treatment of diseases such as, pulmonary hypertension, cardiovascular disease, anaphylaxis, diabetes, obesity, cancer, and other diseases, or symptoms associated with these and other diseases, such as nausea, vomiting, pain and inflammation.

Classes IPC  ?

• A61M 15/00 - Inhalateurs
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 31/352 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à six chaînons avec un oxygène comme seul hétéro-atome d'un cycle condensés avec des carbocycles, p. ex. cannabinols, méthanthéline
• A61K 31/495 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec deux azote comme seuls hétéro-atomes d'un cycle, p. ex. pipérazine
• A61K 31/661 - Acides du phosphore ou leurs esters n'ayant pas de liaison P-C, p. ex. fosfosal, dichlorvos, malathion

Abrégé

Disclosed embodiments relate to improved methods for the synthesis of activated fumarate intermediates and their use in chemical synthesis. Disclosed embodiments describe the synthesis of activated fumarate esters including those derived from activating groups including: 4-nitrophenyl, diphenylphophoryl azide, pivaloyl chloride, chlorosulfonyl isocyanate, p-nitrophenol, MEF, trifluoroacetyl and chlorine, for example, ethyl fumaroyl chloride and the subsequent use of the activated ester in situ. Further embodiments describe the improved synthesis of substituted aminoalkyl-diketopiperazines from unisolated and unpurified intermediates allowing for improved yields and reactor throughput.

Classes IPC  ?

• C07D 241/08 - Composés hétérocycliques contenant des cycles diazine-1,4 ou diazine-1,4 hydrogéné non condensés avec d'autres cycles comportant une ou deux liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec des atomes d'oxygène liés directement aux atomes de carbone du cycle
• C07C 67/30 - Préparation d'esters d'acides carboxyliques par modification de la partie acide de l'ester sans introduction d'un groupe ester
• C07C 67/39 - Préparation d'esters d'acides carboxyliques par oxydation des groupes précurseurs de la partie acide de l'ester
• C07C 201/12 - Préparation de composés nitrés par des réactions ne créant pas de groupes nitro

Abrégé

The disclosed embodiments detail improved methods for the synthesis of diketopiperazines from amino acids. In particular improved methods for the cyclocondensation and purification of N-protected 3,6-(aminoalkyl)-2,5-diketopiperazines from N-protected amino acids. Disclosed embodiments describe methods for the synthesis of 3,6-bis-[N-protected aminoalkyl]-2,5-diketopiperazine comprising heating a mixture of an amino acid in the presence of a catalyst in an organic solvent. The catalyst is selected from the group comprising sulfuric acid, phosphoric acid, p-toluenesulfonic acid, 1-propylphosphonic acid cyclic anhydride, tributyl phosphate, phenyl phosphonic acid and phosphorous pentoxide among others. The solvent is selected from the group comprising: dimethylacetamide, N-methyl-2-pyrrolidone, diglyme, ethyl glyme, proglyme, ethyldiglyme, m-cresol, p-cresol, o-cresol, xylenes, ethylene glycol and phenol among others.

Classes IPC  ?

• C07D 241/08 - Composés hétérocycliques contenant des cycles diazine-1,4 ou diazine-1,4 hydrogéné non condensés avec d'autres cycles comportant une ou deux liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec des atomes d'oxygène liés directement aux atomes de carbone du cycle
• B01J 31/02 - Catalyseurs contenant des hydrures, des complexes de coordination ou des composés organiques contenant des composés organiques ou des hydrures métalliques

Abrégé

Disclosed herein are diketopiperazine microparticles having high capacity for adsorbing a drug or active agent. In particular, the diketopiperazine microparticle are formed using fumaryl diketopiperazine and can comprise a drug in large doses for the treatment of disease or disorders by pulmonary delivery via oral inhalation.

Classes IPC  ?

• A61K 47/22 - Composés hétérocycliques, p. ex. acide ascorbique, tocophérol ou pyrrolidones
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 9/14 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres
• A61K 38/28 - Insulines
• A61K 9/50 - Microcapsules

Abrégé

Described herein are an interactive apparatus and methods for sensing and measuring real-time characteristic patterns of a subject's use of a dry powder inhalation system. The inhaler device can be used in a wireless communication mode to communicate with a display to assess the subject's usage of the inhalation system concurrently as the inhalation is performed and thus the subject's inhalation can be evaluated as well as the performance of the inhalation system. The system can also detect the identity of the medicament, its dosage, lot, expiration, etc. and the characteristics profile of a dry powder formulation emitted from the inhalation system in use.

Classes IPC  ?

• A61M 15/00 - Inhalateurs
• G09B 5/02 - Matériel à but éducatif à commande électrique avec présentation visuelle du sujet à étudier, p. ex. en utilisant une bande filmée
• G09B 23/28 - Modèles à usage scientifique, médical ou mathématique, p. ex. dispositif en vraie grandeur pour la démonstration pour la médecine
• A61K 38/28 - Insulines
• A61K 47/22 - Composés hétérocycliques, p. ex. acide ascorbique, tocophérol ou pyrrolidones

Produits et services

Licensing to others of technology, namely, licensing of technologies related to drug formulations and medical devices used in connection with the delivery of pharmaceuticals via inhalation; Licensing to others intellectual property related to drug formulations and medical devices used in connection with the delivery of pharmaceuticals via inhalation

Produits et services

Scientific and medical research and development in the field of medical devices and apparatuses for drug delivery, namely, disposable pumps for subcutaneous infusion of pharmaceutical formulations; product design and development for others in the field of medical devices and medical technology for drug delivery

Produits et services

Downloadable software in the nature of a mobile application for reading information and data from a medical device, for use by medical professionals and/or patients; downloadable software for coaching and teaching intended to assist users to properly use the inhaler, namely, training with inhalers without medication for medical instruction purposes to teach inhaler use technique.

Abrégé

A method for preventing or reducing adverse effects such as profuse sweating, nausea and vomiting, which normally are associated with subcutaneous and intravenous administration of glucagon-like peptide 1 (GLP-1) therapy is provided. In particular, the method comprises the rapid administration of a GLP-1 formulation into the pulmonary circulation such as by inhalation, directly into pulmonary alveolar capillaries using a dry powder drug delivery system.

Classes IPC  ?

• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
• A61K 38/26 - Glucagons
• A61K 38/28 - Insulines
• A61K 31/495 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec deux azote comme seuls hétéro-atomes d'un cycle, p. ex. pipérazine
• A61M 15/00 - Inhalateurs

Abrégé

The present invention relates to pharmaceutical compositions for inhalation comprising a therapeutically effective dose of clofazimine wherein the clofazimine is provided in the form of dry powder, and processes for their preparation. Furthermore, the present invention provides pharmaceutical combinations comprising clofazimine in the form of an aerosol for pulmonary inhalation. The combinations and compositions provided by the present invention may be used in the treatment and/or prophylaxis of pulmonary infections caused by mycobacteria and other gram-positive bacteria, and of pulmonary fungal infections.

Classes IPC  ?

• A61K 31/498 - Pyrazines ou pipérazines condensées en ortho ou en péri avec des systèmes carbocycliques, p. ex. quinoxaline, phénazine
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 9/16 - AgglomérésGranulésMicrobilles
• A61K 31/47 - QuinoléinesIsoquinoléines
• A61K 31/606 - Acide salicyliqueSes dérivés ayant des groupes amino
• A61K 31/546 - Composés contenant des systèmes cycliques thia-5 aza-1 bicyclo [4.2.0] octane, c.-à-d. composés contenant un système cyclique de formule , p. ex. céphalosporines, céfaclor, céphalexine contenant d'autres hétérocycles, p. ex. céphalotine
• A61K 31/7036 - Composés ayant des radicaux saccharide liés à des composés non-saccharide par des liaisons glycosidiques liés à un composé carbocyclique, p. ex. phloridzine ayant au moins un groupe amino lié directement au carbocycle, p. ex. streptomycine, gentamycine, amikacine, validamycine, fortimicines
• A61K 31/7048 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'oxygène comme hétéro-atome d'un cycle, p. ex. leucoglucosane, hespéridine, érythromycine, nystatine
• A61K 31/4965 - Pyrazines non condensées
• A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p. ex. rifampine, thiothixène ou sparfloxacine
• A61K 31/4709 - Quinoléines non condensées contenant d'autres hétérocycles
• A61K 31/5383 - 1,4-Oxazines, p. ex. morpholine condensées en ortho ou en péri avec des systèmes hétérocycliques

Abrégé

A method of introducing a physiologically-active agent into the circulatory system of a mammal is disclosed herein. The method utilizes a rapid drug delivery system which prevents deactivation or degradation of the active agent being administered to a patient in need of treatment. In particular, the drug delivery system is designed for pulmonary drug delivery such as by inhalation, for delivery of the active agents such as proteins and peptides to the pulmonary circulation in a therapeutically effective manner avoiding degradation of the active agents in peripheral and vascular tissue before reaching the target site.

Classes IPC  ?

• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 9/16 - AgglomérésGranulésMicrobilles
• A61K 31/495 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec deux azote comme seuls hétéro-atomes d'un cycle, p. ex. pipérazine
• A61K 38/26 - Glucagons

Produits et services

Pharmaceutical preparations, namely, pharmaceutical preparations for the treatment of diabetes, endocrine diseases and disorders; pharmaceutical preparations containing insulin; pharmaceutical preparations for the treatment of metabolic diseases and disorders, lung diseases and disorders, including, pulmonary arterial hypertension, interstitial lung diseases and pulmonary fibrosis Medical devices, namely, inhalers, cartridges, and inhaler systems comprising inhalers and cartridges for administration of pharmaceuticals, all provided empty; medical devices, namely, instruments and apparatus provided empty used for the inhalation of pharmaceuticals Medical information services, namely, providing a website in the medical, pharmaceutical and health fields featuring information related to health, wellness, healthcare, patient support services, pharmaceuticals, pharmaceutical access, drug safety and drug compatibility in relation to therapy and treatment of individuals, adherence to pharmaceutical protocols, and the diagnostic, prophylactic and therapeutic properties of pharmaceuticals; medical care consulting services in the fields of diagnostics, patient treatment and treatment protocols; prescription reminder service for reminding patients of pharmaceutical preparation, dosage, allergic sensitivity, and refills for medical treatment purposes; medical services in the nature of providing medical advice in the field of pharmaceutical use, patient health and treatment services; medical services in the nature of providing information on health, wellness, healthcare, patient support services, pharmaceuticals, pharmaceutical access, drug safety and drug compatibility relating to therapy and the diagnostic, prophylactic and therapeutic properties of pharmaceuticals

Produits et services

Pharmaceutical preparations, namely, pharmaceutical preparations for the treatment of diabetes, endocrine diseases and disorders; pharmaceutical preparations containing insulin; pharmaceutical preparations for the treatment of metabolic diseases and disorders, lung diseases and disorders, including, pulmonary arterial hypertension, interstitial lung diseases and pulmonary fibrosis Medical devices, namely, inhalers, cartridges, and inhaler systems comprising inhalers and cartridges for administration of pharmaceuticals, all provided empty; medical devices, namely, instruments and apparatus provided empty used for the inhalation of pharmaceuticals Medical information services, namely, providing a website in the medical, pharmaceutical and health fields featuring information related to health, wellness, healthcare, patient support services, pharmaceuticals, pharmaceutical access, drug safety and drug compatibility in relation to therapy and treatment of individuals, adherence to pharmaceutical protocols, and the diagnostic, prophylactic and therapeutic properties of pharmaceuticals; medical care consulting services in the fields of diagnostics, patient treatment and treatment protocols; prescription reminder service for reminding patients of pharmaceutical preparation, dosage, allergic sensitivity, and refills for medical treatment purposes; medical services in the nature of providing medical advice in the field of pharmaceutical use, patient health and treatment services; medical services in the nature of providing information on health, wellness, healthcare, patient support services, pharmaceuticals, pharmaceutical access, drug safety and drug compatibility relating to therapy and the diagnostic, prophylactic and therapeutic properties of pharmaceuticals

Produits et services

(1) Downloadable software in the nature of a mobile application for reading information and data collected from inhalers, for use by medical professionals and patients; downloadable software for coaching and teaching intended to assist users to properly use the inhaler, namely, training with inhalers without medication for medical instruction purposes to teach inhaler use technique.

Produits et services

Licensing to others of technology, namely, licensing of technologies related to medical devices; Licensing to others of intellectual property related to medical devices

Abrégé

Embodiments of this invention relate to a fluid delivery device. The fluid delivery device comprises a fluid reservoir for containing a fluid, a first drive mechanism configured to remove a predetermined amount of the fluid from the fluid reservoir when the first drive mechanism is actuated, a needle, a septum and a housing having an orifice. Also disclosed is a method for dispensing a fluid from a fluid delivery device into a patient.

Classes IPC  ?

• A61M 5/155 - Perfusion sous pression, p. ex. utilisant des pompes utilisant des réservoirs sous pression, p. ex. au moyen de pistons mis sous pression par un gaz
• A61M 5/145 - Perfusion sous pression, p. ex. utilisant des pompes utilisant des réservoirs sous pression, p. ex. au moyen de pistons
• A61M 5/168 - Moyens pour commander l'écoulement des agents vers le corps ou pour doser les agents à introduire dans le corps, p. ex. compteurs de goutte-à-goutte
• A61M 5/142 - Perfusion sous pression, p. ex. utilisant des pompes
• A61M 5/158 - Aiguilles

Produits et services

Medical device for filling infusion pumps with fluids excluding vials, syringes, cartridges, and pharmaceutical primary containers

Abrégé

An adapter (650) for transferring fluid between a first device (100) and a second device (800). The adapter comprises a first end (652) for receiving the first device, wherein the first end includes a side wall for locating around the first device (100). The adapter (650) further comprises a second end (654) for engaging the first device (100), and including a retaining member (656; 658; 662), wherein the retaining member (656; 658; 662) is operable to prevent removal of the first device (100) from the adapter (650) upon engagement of the first device (100) with the second end (654). The first end (652) and the second end (654) are open on both ends to comprise a through-bore extending through the adapter (650). In some cases, the first device (100) may be a drug pen containing insulin.

Classes IPC  ?

• A61J 1/20 - Dispositions pour le transfert des liquides, p. ex. du flacon à la seringue
• A61J 1/14 - Récipients spécialement adaptés à des fins médicales ou pharmaceutiques DétailsAccessoires à cet effet

Abrégé

A method for the synthesis of N-protected 3,6-aminoalkyl-2,5-diketopiperazines is provided. The method includes obtaining a cyclic α-N protected active amino ester and adding it to a mixture of an amine catalyst in an organic solvent.

Classes IPC  ?

• C07D 241/08 - Composés hétérocycliques contenant des cycles diazine-1,4 ou diazine-1,4 hydrogéné non condensés avec d'autres cycles comportant une ou deux liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec des atomes d'oxygène liés directement aux atomes de carbone du cycle
• C07D 241/04 - Composés hétérocycliques contenant des cycles diazine-1,4 ou diazine-1,4 hydrogéné non condensés avec d'autres cycles ne comportant pas de liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques
• C07D 241/10 - Composés hétérocycliques contenant des cycles diazine-1,4 ou diazine-1,4 hydrogéné non condensés avec d'autres cycles comportant trois liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques

Abrégé

The present invention relates to pharmaceutical compositions for inhalation comprising a therapeutically effective dose of clofazimine wherein the clofazimine is provided in the form of a suspension, and processes for their preparation. Furthermore, the present invention provides pharmaceutical combinations comprising clofazimine in the form of an aerosol for pulmonary inhalation. The combinations and compositions provided by the present invention may be used in the treatment and/or prophylaxis of pulmonary infections caused by mycobacteria and other gram-positive bacteria, and of pulmonary fungal infections.

Classes IPC  ?

• A61K 31/498 - Pyrazines ou pipérazines condensées en ortho ou en péri avec des systèmes carbocycliques, p. ex. quinoxaline, phénazine
• A61K 9/10 - DispersionsÉmulsions
• A61K 31/47 - QuinoléinesIsoquinoléines
• A61K 47/02 - Composés inorganiques
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine

Abrégé

This application concerns pharmaceutical compositions comprising cannabinoids which are suitable for subcutaneous administration in human subjects. Thus, this application concerns pharmaceutical compositions for subcutaneous administration. The pharmaceutical compositions according to the invention are particularly suitable for subcutaneous administration, which is advantageous for improving bioavailability and reducing toxicity.

Classes IPC  ?

• A61K 31/352 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à six chaînons avec un oxygène comme seul hétéro-atome d'un cycle condensés avec des carbocycles, p. ex. cannabinols, méthanthéline
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 31/05 - Phénols
• A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
• A61K 31/485 - Dérivés du morphinane, p. ex. morphine, codéine
• A61M 5/145 - Perfusion sous pression, p. ex. utilisant des pompes utilisant des réservoirs sous pression, p. ex. au moyen de pistons
• A61M 5/168 - Moyens pour commander l'écoulement des agents vers le corps ou pour doser les agents à introduire dans le corps, p. ex. compteurs de goutte-à-goutte

Abrégé

The present disclosure relates to inhalable dry powder compositions comprising cannabinoids. In particular, the formulations are intended for use with dry powder inhalers for single use or multiple use comprising replaceable cartridges for delivery to the deep lung as medicinal agents. The inhalable dry powders are useful in the treatment of diseases and disorders, including pain.

Classes IPC  ?

• A61K 31/495 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec deux azote comme seuls hétéro-atomes d'un cycle, p. ex. pipérazine
• A61K 31/05 - Phénols
• A61K 31/352 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à six chaînons avec un oxygène comme seul hétéro-atome d'un cycle condensés avec des carbocycles, p. ex. cannabinols, méthanthéline
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 9/16 - AgglomérésGranulésMicrobilles

Produits et services

Providing a website for medical professionals and patients featuring medical information and data; providing medical information and data; providing medical information via posts on on-line social media platforms in the medical, pharmaceutical and health fields featuring information related to health, wellness, healthcare, patient support services, pharmaceuticals, pharmaceutical access, drug safety and/or drug compatibility in relation to therapy and treatment of individuals, adherence to pharmaceutical protocols, and the diagnostic prophylactic and therapeutic properties of pharmaceuticals; medical care consulting services in the fields of diagnostics, patient treatment and treatment protocols

Abrégé

A method, composition and kit for the treatment of fibrotic lung disease are disclosed. The method utilizes a combination product for inhalation comprising a therapeutic amount of a dry powder formulation provided in an inhaler to be administered to a subject in need by oral inhalation. The composition comprise diketopiperazine particles for pulmonary inhalation.

Classes IPC  ?

• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 9/16 - AgglomérésGranulésMicrobilles
• A61K 47/18 - AminesAmidesUréesComposés d’ammonium quaternaireAcides aminésOligopeptides ayant jusqu’à cinq acides aminés
• A61K 31/4412 - Pyridines non condenséesLeurs dérivés hydrogénés ayant des groupes oxo liés directement à l'hétérocycle
• A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p. ex. rifampine, thiothixène ou sparfloxacine
• A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
• A61P 11/00 - Médicaments pour le traitement des troubles du système respiratoire
• A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes

Abrégé

A method, composition and kit for the treatment of fibrotic lung disease are disclosed. The method utilizes a combination product for inhalation comprising a therapeutic amount of a dry powder formulation provided in an inhaler to be administered to a subject in need by oral inhalation. The composition comprise diketopiperazine particles for pulmonary inhalation.

Classes IPC  ?

• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 9/16 - AgglomérésGranulésMicrobilles
• A61K 31/4412 - Pyridines non condenséesLeurs dérivés hydrogénés ayant des groupes oxo liés directement à l'hétérocycle
• A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p. ex. rifampine, thiothixène ou sparfloxacine
• A61K 47/18 - AminesAmidesUréesComposés d’ammonium quaternaireAcides aminésOligopeptides ayant jusqu’à cinq acides aminés
• A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
• A61P 11/00 - Médicaments pour le traitement des troubles du système respiratoire
• A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes

Abrégé

Methods of treatment of pulmonary hypertension comprising dry powder inhalation administration of imatinib, a pharmaceutically acceptable salt, or a derivative thereof, are provided. Dry powder inhalable compositions comprising imatinib, a pharmaceutically acceptable salt, or a derivative thereof, are also provided as well as methods of making the same.

Classes IPC  ?

• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 9/14 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres
• A61K 31/506 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime non condensées et contenant d'autres hétérocycles
• A61K 47/22 - Composés hétérocycliques, p. ex. acide ascorbique, tocophérol ou pyrrolidones
• A61P 11/00 - Médicaments pour le traitement des troubles du système respiratoire

Abrégé

Methods of treatment of pulmonary hypertension comprising dry powder inhalation administration of imatinib, a pharmaceutically acceptable salt, or a derivative thereof, are provided. Dry powder inhalable compositions comprising imatinib, a pharmaceutically acceptable salt, or a derivative thereof, are also provided as well as methods of making the same.

Classes IPC  ?

• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 9/14 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres
• A61K 47/22 - Composés hétérocycliques, p. ex. acide ascorbique, tocophérol ou pyrrolidones
• A61K 31/506 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime non condensées et contenant d'autres hétérocycles
• A61P 11/00 - Médicaments pour le traitement des troubles du système respiratoire

Abrégé

A medicament delivery device may comprise a medicament chamber configured to hold a medicament, a plunger configured to move relative to the medicament chamber to expel the medicament from the medicament chamber, a pin configured to move from a first pin position wherein the pin prevents movement of the plunger to a second pin position wherein the pin allows movement of the plunger, an actuation assembly configured to move the pin from the first pin position to the second pin position, and a needle coupled to the medicament chamber. The medicament may flow through the needle from the medicament chamber to a user. The actuation assembly may be configured to automatically move the pin after a predetermined time delay.

Classes IPC  ?

• A61M 5/142 - Perfusion sous pression, p. ex. utilisant des pompes
• A61M 5/145 - Perfusion sous pression, p. ex. utilisant des pompes utilisant des réservoirs sous pression, p. ex. au moyen de pistons
• A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles

Produits et services

Providing medical information via posts on on-line social media platforms in the medical, pharmaceutical and health fields featuring information related to health, wellness, healthcare, patient support services, pharmaceuticals, pharmaceutical access, drug safety and/or drug compatibility in relation to therapy and treatment of individuals, adherence to pharmaceutical protocols, and the diagnostic prophylactic and therapeutic properties of pharmaceuticals; medical care consulting services in the fields of diagnostics, patient treatment and treatment protocols

Abrégé

Methods of treatment of pulmonary hypertension comprising dry powder inhalation administration of imatinib, a pharmaceutically acceptable salt, or a derivative thereof, are provided. Dry powder inhalable compositions comprising imatinib, a pharmaceutically acceptable salt, or a derivative thereof, are also provided as well as methods of making the same.

Classes IPC  ?

• A61K 31/506 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime non condensées et contenant d'autres hétérocycles
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier

Abrégé

A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin, oxyntomodulin and glucagon-like peptide.

Classes IPC  ?

• A61M 15/00 - Inhalateurs
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 38/00 - Préparations médicinales contenant des peptides
• A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
• A61K 38/22 - Hormones
• A61K 38/26 - Glucagons
• A61K 38/28 - Insulines
• A61K 47/22 - Composés hétérocycliques, p. ex. acide ascorbique, tocophérol ou pyrrolidones

Produits et services

Downloadable software in the nature of a mobile application for reading information and data from a medical device, for use by medical professionals and/or patients; downloadable software for coaching and teaching intended to assist users to properly use the inhaler, namely, training with inhalers without medication for medical instruction purposes to teach inhaler use technique

Produits et services

Downloadable software in the nature of a mobile application for reading medical information and data from a medical device, for use by medical professionals and patients

Produits et services

Downloadable software in the nature of a mobile application for reading medical information and data from a medical device, for use by medical professionals and patients Medical devices in the nature of inhalers, or inhaler accessory devices used to measure patient inhalation effort and to train patients in personal inhaler use; medical devices in the nature of inhalers, or inhaler accessory devices with features for measuring respiratory effort and facilitating the training of patients in use of inhalers; medical devices in the nature of inhalers, or inhaler accessory devices with features for the measurement of respiratory patterns of patients; medical devices included as a component of inhaler systems for medical use, namely, patient monitors for monitoring and measuring respiration; medical devices included as a component of inhaler systems for medical use, namely, devices used to indicate dosing of medication; medical devices included as a component of inhaler systems for medical use, namely, devices used to transmit and receive data regarding inhalation, respiration, or dosage

Produits et services

Medical devices in the nature of inhalers, or inhaler accessory devices used to measure patient inhalation effort and to train patients in personal inhaler use; medical devices in the nature of inhalers, or inhaler accessory devices with features for measuring respiratory effort and facilitating the training of patients in use of inhalers; medical devices in the nature of inhalers, or inhaler accessory devices with features for the measurement of respiratory patterns of patients; medical devices included as a component of inhaler systems for medical use, namely, patient monitors for monitoring and measuring respiration; medical devices included as a component of inhaler systems for medical use, namely, devices used to indicate dosing of medication; medical devices included as a component of inhaler systems for medical use, namely, devices used to transmit and receive data regarding inhalation, respiration, or dosage

Abrégé

Disclosed herein are DKP microcrystals made by an improved method where they do not irreversibly self-assemble into microparticles. The microcrystals can be dispersed by atomization and re-formed by spray drying into particles having spherical shell morphology. Active agents and excipients can be incorporated into the particles by spray drying a solution containing the components to be incorporated into microcrystalline diketopiperazine particles. In particular, the microcrystalline particle compositions are suitable for pulmonary drug delivery of one or more peptides, proteins, nucleic acids and/or small organic molecules.

Classes IPC  ?

• C07D 241/08 - Composés hétérocycliques contenant des cycles diazine-1,4 ou diazine-1,4 hydrogéné non condensés avec d'autres cycles comportant une ou deux liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec des atomes d'oxygène liés directement aux atomes de carbone du cycle
• A61K 38/26 - Glucagons
• A61K 38/28 - Insulines
• A61K 9/14 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres
• A61P 3/10 - Médicaments pour le traitement des troubles du métabolisme de l'homéostase du glucose de l'hyperglycémie, p. ex. antidiabétiques
• A61K 9/50 - Microcapsules
• B01D 1/18 - Évaporation par pulvérisation pour obtenir des solides secs

Abrégé

A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided.

Classes IPC  ?

• A61M 15/00 - Inhalateurs
• A61K 47/22 - Composés hétérocycliques, p. ex. acide ascorbique, tocophérol ou pyrrolidones
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
• A61K 38/22 - Hormones
• A61K 38/26 - Glucagons
• A61K 38/28 - Insulines

Abrégé

The present invention relates to pharmaceutical compositions for inhalation comprising a therapeutically effective dose of bedaquiline wherein the bedaquiline is provided in the form of a suspension, or in which the bedaquiline is provided in the form of a dry powder, and processes for their preparation. Furthermore, the present invention provides pharmaceutical combinations comprising bedaquiline in the form of an aerosol for pulmonary inhalation. The combinations and compositions provided by the present invention may be used in the treatment and/or prophylaxis of pulmonary infections caused by mycobacteria and other gram-positive bacteria.

Classes IPC  ?

• A61K 31/47 - QuinoléinesIsoquinoléines
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61J 7/00 - Dispositifs pour administrer les médicaments par voie buccale, p. ex. cuillèresDispositifs pour compter les pilulesDispositions pour l'indication ou le rappel du moment où l'on doit prendre des médicaments
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
• A61K 31/498 - Pyrazines ou pipérazines condensées en ortho ou en péri avec des systèmes carbocycliques, p. ex. quinoxaline, phénazine
• A61P 31/04 - Agents antibactériens

Abrégé

A fluid delivery device for administering a first medicament and a second medicament includes a first fluid reservoir configured to contain the first medicament and a second fluid reservoir configured to contain the second medicament. The fluid delivery device may include one or more basal drive mechanisms to provide a basal delivery of one or more of the first and second medicaments. The fluid delivery device may further include one or more bolus drive mechanisms to provide a bolus delivery of one or more of the first and second medicaments.

Classes IPC  ?

• A61M 5/14 - Dispositifs de perfusion, p. ex. perfusion par gravitéPerfusion sanguineAccessoires à cet effet
• A61M 5/145 - Perfusion sous pression, p. ex. utilisant des pompes utilisant des réservoirs sous pression, p. ex. au moyen de pistons
• A61M 5/168 - Moyens pour commander l'écoulement des agents vers le corps ou pour doser les agents à introduire dans le corps, p. ex. compteurs de goutte-à-goutte
• A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles

Produits et services

Arranging and conducting conferences, seminars and non-downloadable webinars in the field of health, wellness, healthcare, patient support services, pharmaceuticals, pharmaceutical access, drug safety and drug compatibility in relation to therapy and treatment of individuals, adherence to pharmaceutical protocols, and the diagnostic, prophylactic and therapeutic properties of pharmaceuticals; providing non-downloadable podcasts in the field of health, wellness, healthcare, patient support services, pharmaceuticals, pharmaceutical access, drug safety and/or drug compatibility in relation to therapy and treatment of individuals, adherence to pharmaceutical protocols, and the diagnostic, prophylactic and therapeutic properties of pharmaceuticals (terms considered too vague by the International Bureau - Rule 13 (2) (b) of the Regulations). Provision of information related to health, wellness, healthcare, patient support services, pharmaceuticals, pharmaceutical access, drug safety and/or drug compatibility in relation to therapy and treatment of individuals, adherence to pharmaceutical protocols, and the diagnostic, prophylactic and therapeutic properties of pharmaceuticals.

Abrégé

Provided are novel treprostinil based compounds, methods of treatment using the same, and their methods of making.

Classes IPC  ?

• C07D 241/08 - Composés hétérocycliques contenant des cycles diazine-1,4 ou diazine-1,4 hydrogéné non condensés avec d'autres cycles comportant une ou deux liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec des atomes d'oxygène liés directement aux atomes de carbone du cycle
• A61P 9/04 - Agents inotropes, c.-à-d. stimulants de la contraction cardiaqueMédicaments pour le traitement de l'insuffisance cardiaque
• A61P 9/10 - Médicaments pour le traitement des troubles du système cardiovasculaire des maladies ischémiques ou athéroscléreuses, p. ex. médicaments antiangineux, vasodilatateurs coronariens, médicaments pour le traitement de l'infarctus du myocarde, de la rétinopathie, de l'insuffisance cérébro-vasculaire, de l'artériosclérose rénale
• A61P 9/12 - Antihypertenseurs
• A61P 9/14 - VasoprotecteursAntihémorroïdauxMédicaments pour le traitement des varicesStabilisateurs capillaires
• A61P 11/06 - Antiasthmatiques
• A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires
• A61P 25/02 - Médicaments pour le traitement des troubles du système nerveux des neuropathies périphériques

Abrégé

Provided are novel treprostinil based compounds, methods of treatment using the same, and their methods of making.

Classes IPC  ?

• C07D 241/08 - Composés hétérocycliques contenant des cycles diazine-1,4 ou diazine-1,4 hydrogéné non condensés avec d'autres cycles comportant une ou deux liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec des atomes d'oxygène liés directement aux atomes de carbone du cycle
• A61K 31/4965 - Pyrazines non condensées
• A61P 11/00 - Médicaments pour le traitement des troubles du système respiratoire
• A61P 9/04 - Agents inotropes, c.-à-d. stimulants de la contraction cardiaqueMédicaments pour le traitement de l'insuffisance cardiaque
• A61P 9/10 - Médicaments pour le traitement des troubles du système cardiovasculaire des maladies ischémiques ou athéroscléreuses, p. ex. médicaments antiangineux, vasodilatateurs coronariens, médicaments pour le traitement de l'infarctus du myocarde, de la rétinopathie, de l'insuffisance cérébro-vasculaire, de l'artériosclérose rénale
• A61P 9/12 - Antihypertenseurs
• A61P 9/14 - VasoprotecteursAntihémorroïdauxMédicaments pour le traitement des varicesStabilisateurs capillaires
• A61P 11/06 - Antiasthmatiques
• A61P 25/02 - Médicaments pour le traitement des troubles du système nerveux des neuropathies périphériques
• A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires