Abrégé

The present document describes an ex vivo method of stimulating an isolated natural killer (NK) cell by treating them with an effective amount of a compound of structural Formula I, of structural Formula II, or pharmaceutically acceptable salts thereof, and stereoisomers thereof, or combinations thereof: (I) and (II). The present document also describes stimulated isolated NK cell and compositions comprising the same, and their use in methods for the prevention or treatment of cancer in subjects in need thereof. The present document describes an ex vivo method of stimulating an isolated natural killer (NK) cell by treating them with an effective amount of a compound of structural Formula I, of structural Formula II, or pharmaceutically acceptable salts thereof, and stereoisomers thereof, or combinations thereof: (I) and (II). The present document also describes stimulated isolated NK cell and compositions comprising the same, and their use in methods for the prevention or treatment of cancer in subjects in need thereof.

Classes IPC  ?

• A61K 35/17 - LymphocytesLymphocytes BLymphocytes TCellules tueuses naturellesLymphocytes activés par un interféron ou une cytokine
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
• C12N 5/0783 - Cellules TCellules NKProgéniteurs de cellules T ou NK

Abrégé

The present document describes methods for the treatment of cancer comprising administering to a subject in need thereof a therapeutically effective amount of a compound of structural Formula (I) or Formula (II), or pharmaceutically acceptable salts thereof, and stereoisomers thereof, in combination with an immune checkpoint inhibitor, for the treatment of cancer.

Classes IPC  ?

• A61K 31/675 - Composés du phosphore ayant l'azote comme hétéro-atome d'un cycle, p. ex. phosphate de pyridoxal
• A61K 31/67 - Composés du phosphore ayant le soufre comme hétéro-atome d'un cycle
• A61K 31/662 - Acides du phosphore ou leurs esters ayant des liaisons P-C, p. ex. foscarnet, trichlorfon
• A61K 31/665 - Composés du phosphore ayant l'oxygène comme hétéro-atome d'un cycle, p. ex. fosfomycine
• A61K 31/683 - Diesters d'acide du phosphore avec deux composés hydroxyle, p. ex. phosphatidylinositols
• A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire

Abrégé

The present document describes an ex vivo method of stimulating an isolated natural killer (NK) cell by treating them with an effective amount of a compound of structural Formula I, of structural Formula II, or pharmaceutically acceptable salts thereof, and stereoisomers thereof, or combinations thereof: (I) and (II). The present document also describes stimulated isolated NK cell and compositions comprising the same, and their use in methods for the prevention or treatment of cancer in subjects in need thereof.

Classes IPC  ?

• C12N 5/0783 - Cellules TCellules NKProgéniteurs de cellules T ou NK
• A61K 35/17 - LymphocytesLymphocytes BLymphocytes TCellules tueuses naturellesLymphocytes activés par un interféron ou une cytokine
• A61P 35/00 - Agents anticancéreux
• C07F 9/38 - Acides phosphoniques [R—P(:O)(OH)2]Acides thiophosphoniques
• C07F 9/60 - Systèmes cycliques quinoléiniques ou quinoléiniques hydrogénés
• C07F 9/6553 - Composés hétérocycliques, p. ex. contenant du phosphore comme hétéro-atome du cycle comportant des atomes de soufre, avec ou sans atomes de sélénium ou de tellure, comme uniques hétéro-atomes du cycle