Abrégé

A set of laser-scanning systems for augmented reality glasses displays and LiDAR (light detection and ranging) uses photonic integrated circuits to generate multiple modulated laser beams, one or more lenses to collimate and/or focus light from the photonic integrated circuits, scanning mirrors (e.g., microelectromechanical systems (MEMS) mirrors) to scan the laser beams along two axes, and a double-pass configuration to reduce the overall size of the system and enable an inline geometry. The photonic chip has emitters distributed along a thin and narrow bridge, which may be curved. This bridge is inserted into the path of optical system, enabling the double-pass configuration with small amounts of scattering or diffraction of light that passes through/by the bridge on the second pass.

Classes IPC  ?

• G02B 27/01 - Dispositifs d'affichage "tête haute"

Abrégé

Laser-scanning systems for augmented reality glasses displays and LiDAR (light detection and ranging) use photonic integrated circuits to generate multiple collimated (or low-divergence) modulated laser beams. Laser light is guided on the photonic chip, expanded, and emitted from the surface of the chip (using grating coupler devices) as one or more large-diameter (e.g., millimeter-scale), collimated or low-divergence beams. These gratings may be integrated onto movable microelectromechanical systems (MEMS) plates to steer the beam along two angular axes. Alternatively, the beam(s) from the grating(s) may be steered by a separate MEMS mirror integrated onto the photonic chip or on another chip. Such systems enable multi-beam laser scanning systems without collimation lenses, reducing the size and packaging complexity of high-performance laser scanning systems for augmented reality glasses and LiDAR.

Classes IPC  ?

• G02B 26/10 - Systèmes de balayage
• G01S 7/481 - Caractéristiques de structure, p. ex. agencements d'éléments optiques
• G02B 27/01 - Dispositifs d'affichage "tête haute"

Abrégé

The present disclosure provides methods of preventing colorectal cancer and/or killing colibactin-producing E. coli. Also provided are prodrug antibiotics suitable for preventing colorectal cancer and/or killing colibactin-producing E. coli, and methods of making prodrug antibiotics. Various prodrug antibiotics may be used. For example, a prodrug antibiotic may be: The present disclosure provides methods of preventing colorectal cancer and/or killing colibactin-producing E. coli. Also provided are prodrug antibiotics suitable for preventing colorectal cancer and/or killing colibactin-producing E. coli, and methods of making prodrug antibiotics. Various prodrug antibiotics may be used. For example, a prodrug antibiotic may be: The present disclosure provides methods of preventing colorectal cancer and/or killing colibactin-producing E. coli. Also provided are prodrug antibiotics suitable for preventing colorectal cancer and/or killing colibactin-producing E. coli, and methods of making prodrug antibiotics. Various prodrug antibiotics may be used. For example, a prodrug antibiotic may be: or any combination thereof, wherein R is a substituted or unsubstituted aliphatic group. In various examples, the prodrug antibiotic may be a salt or in the form of a composition.

Classes IPC  ?

• A61K 38/06 - Tripeptides
• A61P 31/04 - Agents antibactériens

Abrégé

The invention relates to a robotic device with a base structure for insertion into a blood vessel of a vascular system and a foldable structure. The foldable structure comprises a closed retaining section configured for retaining an agent for medical use. The foldable structure further is configured for opening the closed retaining section and releasing the agent upon reaching a predefined internal energy level.

Classes IPC  ?

• A61M 31/00 - Dispositifs pour l'introduction ou la rétention d'agents, p. ex. de remèdes, dans les cavités du corps
• A61B 34/00 - Chirurgie assistée par ordinateurManipulateurs ou robots spécialement adaptés à l’utilisation en chirurgie
• A61B 34/30 - Robots chirurgicaux

Abrégé

It has been surprisingly found that human oocytes lack the important spindle-associated protein KIFC1/HSET. The application describes a method stabilising the human spindle with KIFC1/HSET. Specifically, the method relates to introducing (i) KIFC1/HSET protein or (ii) mRNA encoding KIFC1/HSET into a human oocyte. Furthermore, the application relates to a non-naturally occurring human oocyte, wherein a (i) KIFC1/HSET protein or (ii) KIFC1/HSET mRNA has been introduced into a naturally occurring human oocyte thereby obtaining the non-naturally occurring oocyte. Additionally, the application relates to a (i) KIFC1/HSET protein or (ii) mRNA encoding the KIFC1/HSET for use in a method of lowering the probability of having a disorganized and/or a multipolar spindle during mitosis in a human zygote by introducing the (i) KIFC1/HSET protein or (ii) mRNA encoding the KIFC1/HSET into the human zygote. Moreover, the application discloses a complex comprising (i) a KIFC1/HSET protein and (ii) a human meiotic spindle or a human mitotic spindle, wherein the KIFC1/HSET protein has been introduced into a human oocyte or zygote.

Classes IPC  ?

• C12N 15/89 - Introduction de matériel génétique étranger utilisant des procédés non prévus ailleurs, p. ex. co-transformation utilisant la micro-injection
• C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
• C12N 5/073 - Cellules ou tissus embryonnairesCellules fœtales ou tissus fœtaux

Produits et services

Downloadable digital photos; Downloadable electronic publications in the nature of magazines; Audio and video recording and reproduction apparatus. Photographs [printed]; Photographic albums; Magazines; Newspapers; Printed books; Calendars; Posters; Maps; Postcards; Notebooks and planners; Drawing books; Stationery; Pens; Pencils; Brush pens; Crayons; Drawing instruments; Painting sets for artists; Canvas for painting; Paint boxes for use in schools; Postage stamps; Paper folders; Document folders with clips; Works of art made of paper; Works of art and decorations, including figurines, made primarily of paper and cardboard; Architectural sketches; Architectural models made primarily of paper and cardboard; Paper and plastic bags for wrapping; Paper and cardboard for wrapping and decorating; Paper and cardboard boxes. Bags; Suitcases; Rucksacks; Duffel bags; School bags; Attaché cases; Boxes made of leather; Key cases; Wallets; Purses; Umbrellas. Clothing; Footwear; Headgear. Publication of printed matters for advertising purposes; Computerized file management; Retail sale of works of art. Providing grants for research in art history and architecture. Library services; Research and consultancy library services; Online research and consultancy library services; Archive library services; Electronic library services for the supply of electronic information in the form of text, audio and video information; Library services related to data stored and retrieved by electronic means; Publication of catalogues, newspapers, periodicals, books, and magazines; Publication of instructional books; Publication of photographs; Publication of literary and artistic documents; Research for educational purposes; Video, film and multimedia production and publication; Training services for researchers and academics; Educational services; Education academy services; Arranging and conducting conventions, seminars, conferences and exhibitions for cultural, artistic, educational and entertainment purposes; Conducting workshops and seminars on art appreciation; Information relating to cultural activities; Ticket booking for cultural activities. Electronic storage of documents; Electronic storage of digital photos; Scientific and technological research; Architectural research; Authentication and certification services of works of art; Art and architectural history research and study; Geography research and study; Research and studies on scientific visualization as a communication tool.

Produits et services

Downloadable digital photos; Downloadable electronic publications in the nature of magazines; Audio and video recording and reproduction apparatus. Photographs [printed]; Photographic albums; Magazines; Newspapers; Printed books; Calendars; Posters; Maps; Postcards; Notebooks and planners; Drawing books; Stationery; Pens; Pencils; Brush pens; Crayons; Drawing instruments; Painting sets for artists; Canvas for painting; Paint boxes for use in schools; Postage stamps; Paper folders; Document folders with clips; Works of art made of paper; Works of art and decorations, including figurines, made primarily of paper and cardboard; Architectural sketches; Architectural models made primarily of paper and cardboard; Paper and plastic bags for wrapping; Paper and cardboard for wrapping and decorating; Paper and cardboard boxes. Bags; Suitcases; Rucksacks; Duffel bags; School bags; Attaché cases; Boxes made of leather; Key cases; Wallets; Purses; Umbrellas. Clothing; Footwear; Headgear. Publication of printed matters for advertising purposes; Computerized file management; Retail sale of works of art. Providing grants for research in art history and architecture. Library services; Research and consultancy library services; Online research and consultancy library services; Archive library services; Electronic library services for the supply of electronic information in the form of text, audio and video information; Library services related to data stored and retrieved by electronic means; Publication of catalogues, newspapers, periodicals, books, and magazines; Publication of instructional books; Publication of photographs; Publication of literary and artistic documents; Research for educational purposes; Video, film and multimedia production and publication; Training services for researchers and academics; Educational services; Education academy services; Arranging and conducting conventions, seminars, conferences and exhibitions for cultural, artistic, educational and entertainment purposes; Conducting workshops and seminars on art appreciation; Information relating to cultural activities; Ticket booking for cultural activities. Electronic storage of documents; Electronic storage of digital photos; Scientific and technological research; Architectural research; Authentication and certification services of works of art; Art and architectural history research and study; Geography research and study; Research and studies on scientific visualization as a communication tool.

Abrégé

A conductor device 100, preferably being configured for low temperature applications, comprises multiple conductor wires 10 being arranged along a longitudinal extension of the conductor device 100, and an electrically insulating encapsulation material 20, wherein the conductor wires 10 are encapsulated in the encapsulation material 20, so that each conductor wire 10 is covered by the encapsulation material 20 in all radial directions relative to the longitudinal extension of the conductor device 100, wherein the conductor wires 10 have electric superconductivity at an operation temperature equal to or below −196° C., and each conductor wire 10 has two longitudinal end sections 11 and a self-supporting wire section 12 therebetween. Furthermore, an electrical conductor arrangement including the conductor device and a method of manufacturing the conductor device 100 are described.

Classes IPC  ?

• H01B 12/02 - Conducteurs, câbles ou lignes de transmission supraconducteurs ou hyperconducteurs caractérisés par leurs formes

Abrégé

A method for quantum computing using neutral atoms in an array of optical traps, wherein a first internal state serves as qubit ground state |o>, and a second internal state serves as qubit excited state |1>, includes performing a local single-qubit gate operation comprising: locally and selectively illuminating a qubit prepared in a superposition state |s> of qubit ground state |0> and qubit excited state |1> with a qubit addressing laser at a first qubit addressing laser frequency to cause a differential Stark shift for the qubit ground state |0> and the qubit excited state |1>. The method also includes performing a local two-qubit gate operation comprising: locally and selectively illuminating a pair of qubits prepared in the qubit ground state |0> with the qubit addressing laser at a second qubit addressing laser frequency for coupling the pair of qubits to a Rydberg state |r>.

Classes IPC  ?

• G06N 10/40 - Réalisations ou architectures physiques de processeurs ou de composants quantiques pour la manipulation de qubits, p. ex. couplage ou commande de qubit
• G06N 10/80 - Programmation quantique, p. ex. interfaces, langages ou boîtes à outils de développement logiciel pour la création ou la manipulation de programmes capables de fonctionner sur des ordinateurs quantiquesPlate-formes pour la simulation ou l’accès aux ordinateurs quantiques, p. ex. informatique quantique en nuage

Abrégé

The present invention refers to a process for converting a feed gas stream comprising carbon monoxide and hydrogen as major components (synthesis gas) into higher (C3+) alcohols making use of a catalyst combination of a Fischer-Tropsch catalyst and an olefin hydroformylation catalyst. In a second aspect, the invention relates to a Fischer-Tropsch catalyst suitable to be applied in said process.

Classes IPC  ?

• C07C 29/157 - Préparation de composés comportant des groupes hydroxyle ou O-métal liés à un atome de carbone ne faisant pas partie d'un cycle aromatique à six chaînons par réduction exclusivement des oxydes de carbone avec de l'hydrogène ou des gaz contenant de l'hydrogène caractérisée par le catalyseur utilisé contenant des métaux du groupe du fer, des métaux du groupe du platine, ou leurs composés contenant des métaux du groupe du platine ou leurs composés
• B01J 23/46 - Ruthénium, rhodium, osmium ou iridium
• B01J 23/75 - Cobalt
• B01J 35/00 - Catalyseurs caractérisés par leur forme ou leurs propriétés physiques, en général

Abrégé

A method for optimizing parameters of a physical light propagation model. The method includes making available a physical model of a light propagation in an optical system, radiating an input-light distribution into an excitation path of the optical system using an illumination unit, passing the input light distribution through a scattering body, wherein the scattering body is placed in the excitation path of the optical system so that the input-light distribution is changed to a reflection-light distribution, recording the reflection-light distribution, transferring the recorded reflection-light distribution to the physical model, and calculating distortion parameters of the physical model based on the reflection-light distribution. The distortion parameters characterize the scattering body. The reflection-light distribution is at least partially reflected as fluorescence radiation by a fluorescence-capable body within the scattering body.

Classes IPC  ?

• G01N 21/64 - FluorescencePhosphorescence
• G01N 21/47 - Dispersion, c.-à-d. réflexion diffuse
• G02B 27/00 - Systèmes ou appareils optiques non prévus dans aucun des groupes ,

Abrégé

A beam-steering device (100) for spatial steering of a light beam comprises a waveguide array (10) being arranged on a substrate (50) and comprising a waveguide array input (12), multiple waveguides (14-1, 14-2, . . . , 14-i) and a waveguide array output (16), wherein the multiple waveguides (14-1, 14-2, . . . , 14-i) are adapted for simultaneously guiding light from the waveguide array input (12) to the waveguide array output (16) and for forming a light beam downstream of the waveguide array output (16) by superimposing the light guided by the waveguides (14-1, 14-2, . . . , 14-i), a phase shifter device (18) being arranged for applying controlled phase shifts to the light guided in each of the waveguides (14-1, 14-2, . . . , 14-i), and a grating array (22) including at least one patterned grating in optical communication with the waveguide array output (16), the grating array (22) being configured to radiate the light beam out of the beam-steering device (100) to a surrounding, wherein the waveguide array output (16) is arranged such that the light beam is formed downstream of the waveguide array output (16) with a main lobe and side lobes and with a beam angle Φ in a plane of the substrate (50), that is determined by the controlled phase shifts applied to the light by the phase shifter device (18) and a wavelength of the light, a slab propagation region (20) is arranged between the waveguide array output (16) and the grating array (22) such that the main lobe of the light beam is angularly relayed to the grating array (22) and the side lobes of the light beam leave lateral sides of the slab propagation region (20) before reaching the grating array (22), and the grating array (22) is arranged to radiate the light beam out of the beam-steering device (100) with a first angular direction with respect to the substrate (50), that is determined by the beam angle Φ. Furthermore, a method of beam-steering a light beam is described.

Classes IPC  ?

• G02F 1/29 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p. ex. commutation, ouverture de porte ou modulationOptique non linéaire pour la commande de la position ou de la direction des rayons lumineux, c.-à-d. déflexion
• G02F 1/01 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p. ex. commutation, ouverture de porte ou modulationOptique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur

Abrégé

In The present invention relates in a first aspect to the use of influenza virus defective interfering particles in the prophylactic or therapeutic treatment of coronaviridae infection. In particular, it has been recognized that defective interfering particles of influenza A have beneficial effects in the treatment of SARS coronavirus infection, in particular, SARS-CoV-2 infection. Further, the present invention relates to a pharmaceutical composition for use in treating coronaviridae infection, in particular SARS-CoV-2. In a further aspect, methods for the prophylactic or therapeutic treatments of coronaviridae based on the administration of DIFs are disclosed.

Classes IPC  ?

• A61K 35/76 - VirusParticules sous-viralesBactériophages
• A61P 31/14 - Antiviraux pour le traitement des virus ARN

Abrégé

A photodetector apparatus (100), being configured for detecting light in the visible or infrared spectrum, comprises a substrate (30), a waveguide (20), a detector section (10), a first contact section (50) and a second contact section (52). The substrate (30) has a substrate surface (32) and a cladding layer (40). The waveguide (20) is arranged above the substrate surface (32) in the cladding layer (40) and is adapted for guiding light. The detector section (10) comprises a p-doped region (12, 14) and an ndoped region (16, 18), and the detector section (10′) is arranged for producing charge carriers by the (10) light guided in the waveguide (20). The first contact section (50) is connected to the p-doped region (12, 14) and the second contact section (52) is connected to the n-doped region (16, 18), the first and second contact sections (50, 52) being connectable to a measuring device for measuring an electrical signal based on the charge carriers produced by the light. The waveguide (20) and the detector section (10) are spaced apart by a portion of the cladding layer (40) with a mutual distance such that optical power of the light guided in the waveguide (20) can be gradually transferred from the waveguide (20) to the detector section (10). Furthermore, a method of detecting light in the visible or infrared spectrum is described.

Classes IPC  ?

• H01L 31/107 - Dispositifs sensibles au rayonnement infrarouge, visible ou ultraviolet caractérisés par une seule barrière de potentiel ou de surface la barrière de potentiel fonctionnant en régime d'avalanche, p.ex. photodiode à avalanche
• G02B 6/12 - Guides de lumièreDétails de structure de dispositions comprenant des guides de lumière et d'autres éléments optiques, p. ex. des moyens de couplage du type guide d'ondes optiques du genre à circuit intégré
• G02B 6/122 - Éléments optiques de base, p. ex. voies de guidage de la lumière

Abrégé

A display engine for a laser-scanning head-mounted display uses one or more photonic integrated circuit chips to generate multiple intensity-modulated laser beams. These beams are scanned across the field of view with an off-chip scanning mirror, one or more actuators integrated with the chip, or a combination of an off-chip scanning mirror and integrated actuators. The actuators move output couplers (e.g., waveguide emitters with waveguide edge couplers at the ends) that emit light from the photonic chip, forming multiple independent optical beams. Movement of the actuator translates the beams such that each of the beams addresses a portion of the field of view of a displayed image. An optical combiner and relay optics expands these beams and directs them toward the eye of the person wearing the display.

Classes IPC  ?

• G02B 27/01 - Dispositifs d'affichage "tête haute"

Abrégé

An optofluidic antenna device (100) for shaping a light field of sample light emitted or scattered by a sample (1) comprises a substrate (10) and a liquid layer (20) being supported by the substrate (10) and being arranged for accommodating the sample (1) to be investigated between a first liquid surface (21) facing to the substrate (10) and a second liquid surface (22) opposite to the first liquid surface (21), wherein a thickness of the liquid layer (20) between the first and second liquid surfaces (21, 22) and refractive indices of the substrate (10) and the liquid layer (20) are selected such that an optofluidic antenna is formed, which is capable of directing the sample light mainly towards the substrate (10), and a gas volume (30) is arranged above the liquid layer (20), so that the second liquid surface (22) is formed as a liquid-gas-interface. Furthermore, a measuring apparatus (300), that comprises the optofluidic antenna device (100), and a method of detecting at least one photon emitted or scat-tered from a sample (1), in particular a single analyte in a liquid, are described.

Classes IPC  ?

• G01N 21/64 - FluorescencePhosphorescence

Abrégé

A measurement device 100 comprises neuronal, in particular retinal, tissue 110 grown from stem cells, the neuronal tissue 110 having a three-dimensional shape neuronal cells that change an electric potential in cells of the neuronal tissue 110 in response to influences that act on the neuronal cells, and a read-out device 130 that is configured to measure neuronal responses of the neuronal tissue 110 via changes in the electric potential generated by the neuronal cells.

Classes IPC  ?

• G01N 33/483 - Analyse physique de matériau biologique
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
• C12N 5/079 - Cellules neurales
• C12N 5/0793 - Neurones
• G01J 1/04 - Pièces optiques ou mécaniques
• G01J 1/42 - Photométrie, p. ex. posemètres photographiques en utilisant des détecteurs électriques de radiations
• G01N 21/00 - Recherche ou analyse des matériaux par l'utilisation de moyens optiques, c.-à-d. en utilisant des ondes submillimétriques, de la lumière infrarouge, visible ou ultraviolette
• G01N 21/64 - FluorescencePhosphorescence
• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique

Abrégé

A method for simultaneous imaging and executing contact-free directed hydrodynamic flow in a specimen. At least one light source dynamically heats the interior and/or a surface of the specimen via a light beam, the beam of the at least one light source is directed to the specimen through an objective of a microscope, the light beam is variably guided to specified locations of the specimen inducing a hydrodynamic flow in the specimen, and imaging the specimen via the same objective as used for introduction of the light beam.

Classes IPC  ?

• G02B 21/36 - Microscopes aménagés pour la photographie ou la projection
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
• G01N 21/64 - FluorescencePhosphorescence
• G02B 21/00 - Microscopes
• G02B 21/02 - Objectifs
• G02B 21/08 - Condensateurs
• G02B 21/28 - Structure du bâti ou statif avec dispositif de réfrigération
• G02B 21/30 - Structure du bâti ou statif avec dispositif de réchauffage
• G01N 15/01 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux spécialement adaptée aux cellules biologiques, p. ex. aux cellules sanguines

Abrégé

Described herein is an immunogenic fusion protein comprising: an immunogenic peptide or an immunogenic variant thereof, the immunogenic peptide comprising the following motifs: —KQPAa; QPAKa; PAKQa; or AKQPa; —NPDPb; PNPDb; DPNPb; or PNPDb; —NANPc; ANPNc; NPNAc; or PNANc; —NVDPd; VDPNd; DPNVd; or PNVDd; and —NANPe; ANPNe; NPNAe; or PNANe. wherein a, b, c, d, and e are each independently 0 or greater and wherein a±b±c±d±e is at least 2; and a nanocage monomer peptide.

Classes IPC  ?

• A61K 39/015 - Antigènes d'Hemosporidia, p. ex. antigènes de Plasmodium
• A61K 39/385 - Haptènes ou antigènes, liés à des supports
• A61P 37/04 - Immunostimulants
• C07K 14/445 - Plasmodium

Abrégé

The invention relates to a tube (100) with a hollow cylindrical elastic base structure (102) for insertion into a blood vessel (200) of a vascular system (202). The tube (100) comprises an outer anisotropic surface structure (104) comprising a geometrical anisotropy between a direction circumferential to the tube and a direction longitudinal to the tube (100). The anisotropic surface structure (104) is configured for establishing an anisotropic friction between the anisotropic surface structure (104) and an inner surface of the blood vessel (200). The anisotropic friction results in a surface propulsion of the tube (100), when the tube (100) is rotated around a central longitudinal body axis (106) of the tube (100). The tube (100) further comprises a magnetic material (108) distributed circumferentially around the tube (100) and configured for establishing within an external magnetic field a rotation of the tube (100) around the central longitudinal body axis (106) of the tube (100).

Classes IPC  ?

• A61B 34/00 - Chirurgie assistée par ordinateurManipulateurs ou robots spécialement adaptés à l’utilisation en chirurgie
• A61M 25/01 - Introduction, guidage, avance, mise en place ou maintien en position des cathéters

Abrégé

A method for optimizing parameters of a physical light propagation model includes providing a physical model of a light propagation in an optical system, radiating an input light distribution using an illumination unit into an excitation path of the optical system, traversing the input light distribution through a scattering body, wherein the scattering body is arranged in the excitation path of the optical system and modifies the input light distribution to form a transmission light distribution to form a reflection light distribution, recording the transmission light distribution or the reflection light distribution, transferring the recorded transmission light distribution or the recorded reflection light distribution to the physical model, and computing transmission distortion parameters of the physical model based on the recorded transmission light distribution or the recorded reflection light distribution. The transmission distortion parameters characterize the scattering body.

Classes IPC  ?

• G02B 21/00 - Microscopes

Abrégé

A microscopic imaging method for creating a microscopic sample image (1A) of a sample (1) comprises the steps of arranging the sample (1) on a sampling crystal (10); irradiating the sample (1) with excitation laser pulses (2, 3) and generating sample response pulses (4) with a sample response field as a result of an interaction of the excitation laser pulses (2, 3) with the sample (1); irradiating the sampling crystal (10) with probe laser pulses (5) being temporally synchronized with the excitation laser pulses (2, 3) and spatially overlapped with the sample response pulses (4) in the sampling crystal (10), wherein the probe laser pulses (5) have a shorter wavelength than the excitation laser pulses (2, 3); detecting the sample response field by electric-field sampling with the sampling crystal (10), using the sample response pulses (4) and the probe laser pulses (5); and calculating the sample image (1A) based on the detected sample response field, wherein the excitation laser pulses (2, 3) have a wavelength in a range from mid-infrared to visible light and the sample response pulses (4) are created by a coherent interaction process induced in the sample (1) and with a fixed phase relationship relative to the excitation laser pulses (2, 3), the sampling crystal (10) is a non-centrosymmetric crystal, the irradiating step is repeated at multiple sample points (1A), wherein at each sample point (1A) the irradiating steps are successively repeated with multiple temporal probe delays of the probe laser pulses (5) relative to the excitation laser pulses (2, 3), at each probe delay, a sum or difference frequency pulse (6) of a sample response pulse (4) and a probe laser pulse (5) is generated, and at each probe delay, a spectral interference pulse (7) is created by a spectral interference of the sum or difference frequency pulse (6) and the current probe laser pulse, the detecting step includes sensing a polarization state of the spectral interference pulse (7) by an ellipsometer device (40) at each probe delay, wherein the local sample response field at the sample point (1A) is derived from the polarization states sensed at all probe delays, and the sample image (1A) is calculated based on the sample response field detected at the sample points (1A). Furthermore, a microscopic imaging apparatus is described.

Classes IPC  ?

• G01N 21/63 - Systèmes dans lesquels le matériau analysé est excité de façon à ce qu'il émette de la lumière ou qu'il produise un changement de la longueur d'onde de la lumière incidente excité optiquement
• G01N 21/65 - Diffusion de Raman
• G02B 21/00 - Microscopes

Abrégé

The present subject matter relates to determine a snapping position in a road network for a destination object by using a cost matrix indicative of accumulative cost values of cells of the matrix. The accumulative cost value of a cell is indicating a cost to travel a path from the cell to a road segment of the road network.

Classes IPC  ?

• G01C 21/34 - Recherche d'itinéraireGuidage en matière d'itinéraire
• G01C 21/32 - Structuration ou formatage de données cartographiques

Abrégé

A method for testing the hydrogen permeability of a test object 1 includes the steps of provision of a sensor device 110 on a first side 3 of the test object 1, application of a test gas 5 including hydrogen 2 to a second side 4 of the test object 1, and detection of permeating hydrogen 2 passing through the test object 1 from the second side 4 to the first side 3 with the sensor device 110, wherein the sensor device 110 includes at least one hydrogen absorbing sensor layer 111 and the detection of the permeating hydrogen 2 including a detection of a change of state of the at least one sensor layer 111. A measuring apparatus 100 for testing the hydrogen permeability of a test object 1 is also described.

Classes IPC  ?

• G01N 15/08 - Recherche de la perméabilité, du volume des pores ou de l'aire superficielle des matériaux poreux
• G01M 3/22 - Examen de l'étanchéité des structures ou ouvrages vis-à-vis d'un fluide par utilisation d'un fluide ou en faisant le vide par détection de la présence du fluide à l'emplacement de la fuite en utilisant des révélateurs particuliers, p. ex. teinture, produits fluorescents, produits radioactifs pour tuyaux, câbles ou tubesExamen de l'étanchéité des structures ou ouvrages vis-à-vis d'un fluide par utilisation d'un fluide ou en faisant le vide par détection de la présence du fluide à l'emplacement de la fuite en utilisant des révélateurs particuliers, p. ex. teinture, produits fluorescents, produits radioactifs pour raccords ou étanchéité de tuyauxExamen de l'étanchéité des structures ou ouvrages vis-à-vis d'un fluide par utilisation d'un fluide ou en faisant le vide par détection de la présence du fluide à l'emplacement de la fuite en utilisant des révélateurs particuliers, p. ex. teinture, produits fluorescents, produits radioactifs pour soupapes
• G01N 33/00 - Recherche ou analyse des matériaux par des méthodes spécifiques non couvertes par les groupes

Abrégé

D).

Classes IPC  ?

• G06N 3/08 - Méthodes d'apprentissage
• G01N 21/64 - FluorescencePhosphorescence
• G02B 21/00 - Microscopes
• G02B 21/36 - Microscopes aménagés pour la photographie ou la projection

Abrégé

A method for determination of molecular parameters for a configuration of a known single organic molecule embedded in an anisotropic environment generated by alignment media, said known single organic molecule comprising particles, is disclosed. The method comprising the steps of: a) Defining a three-dimensional grid that is aligned with the known atomic structure of the alignment medium; b) Placing the particles of the known single organic molecule on the respective grid points of the three-dimensional grid in relation to at least one assigned atom of the alignment medium; c) Determining the interaction between the particles of the single organic molecule and the alignment medium for a set of orientations and a plurality of configurations of the particles; d) Calculating anisotropic parameters obtainable by measuring with nuclear magnetic resonance (NMR) spectroscopy by use of the determined interactions for each of the plurality of configurations of the organic molecule.

Classes IPC  ?

• G16C 20/20 - Identification d’entités moléculaires, de leurs parties ou de compositions chimiques
• G01N 24/08 - Recherche ou analyse des matériaux par l'utilisation de la résonance magnétique nucléaire, de la résonance paramagnétique électronique ou d'autres effets de spin en utilisant la résonance magnétique nucléaire
• G16C 20/30 - Prévision des propriétés des composés, des compositions ou des mélanges chimiques
• G16C 20/50 - Conception moléculaire, p. ex. de médicaments

Abrégé

The invention relates to novel fluorescent dyes with multiple negatively charged groups in their ionized form which are 9-aminoacridines or 1-aminopyrene shaving of one of the following general formulae A-E: or salts or protonated forms thereof, wherein the ionizable groups are typically selected from the following: OH, SH, COOH, SO3H, OSO3H, SO2NHCN, P(O)(OH)2, P(O) (OH)2. The invention further relates to the use of these dyes as fluorescent tags, in particular for reducing sugars and glycans, and to carbohydrate-dye conjugates comprising these dyes as well as to methods for preparing the same. The invention relates to novel fluorescent dyes with multiple negatively charged groups in their ionized form which are 9-aminoacridines or 1-aminopyrene shaving of one of the following general formulae A-E: or salts or protonated forms thereof, wherein the ionizable groups are typically selected from the following: OH, SH, COOH, SO3H, OSO3H, SO2NHCN, P(O)(OH)2, P(O) (OH)2. The invention further relates to the use of these dyes as fluorescent tags, in particular for reducing sugars and glycans, and to carbohydrate-dye conjugates comprising these dyes as well as to methods for preparing the same.

Classes IPC  ?

• G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
• C09B 15/00 - Colorants acridiniques
• C09B 57/00 - Autres colorants synthétiques de structure connue
• C09K 11/06 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances organiques luminescentes
• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

Method of increasing platelet counts in a subject, the method comprising administering to the subject a therapeutically effective amount of a compound that inhibits Biliverdin reductase B (BLVRB) activity by blocking a binding site of BLVRB or a pharmaceutically acceptable salt thereof, wherein the compound does not contain xanthene or acridine moiety is provided.

Classes IPC  ?

• A61K 31/00 - Préparations médicinales contenant des ingrédients actifs organiques
• A61K 31/655 - Composés azoïques(-N=N-), diazoïques (=N2), azoxy (N-O-N ou N(=O)-N), azido (-N3) ou diazoamino (-N=N-N)
• A61K 38/12 - Peptides cycliques
• A61K 31/4245 - Oxadiazoles
• A61K 31/426 - 1,3-Thiazoles
• A61K 31/4196 - 1,2,4-Triazoles
• A61K 31/506 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime non condensées et contenant d'autres hétérocycles
• A61K 31/404 - Indoles, p. ex. pindolol
• A61K 31/343 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à cinq chaînons avec un oxygène comme seul hétéro-atome d'un cycle, p. ex. isosorbide condensés avec un carbocycle, p. ex. coumarane, bufaralol, béfunolol, clobenfurol, amiodarone
• A61K 31/4184 - 1,3-Diazoles condensés avec des carbocycles, p. ex. benzimidazoles
• A61K 31/55 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole
• A61K 31/4709 - Quinoléines non condensées contenant d'autres hétérocycles
• A61K 31/4422 - 1,4-Dihydropyridines, p. ex. nifédipine, nicardipine
• A61K 31/4725 - Isoquinoléines non condensées, p. ex. papavérine contenant d'autres hétérocycles
• A61K 31/196 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe amino le groupe amino étant lié directement à un cycle, p. ex. acide anthranilique, acide méfénamique, diclofénac, chlorambucil
• A61K 31/4402 - Pyridines non condenséesLeurs dérivés hydrogénés substituées uniquement en position 2, p. ex. phéniramine, bisacodyl
• A61K 31/4418 - Pyridines non condenséesLeurs dérivés hydrogénés ayant un carbocycle lié directement à l'hétérocycle, p. ex. cyproheptadine
• A61K 31/41 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec plusieurs hétéro-atomes cycliques, l'un au moins étant l'azote, p. ex. tétrazole

Abrégé

Disclosed are systems and techniques for extracting user body shape (e.g., a representation of the three-dimensional body surface) from user behavioral data. The behavioral data may not be explicitly body-shape-related, and can include shopping history, social media likes, or other recorded behaviors of the user within (or outside of) a networked content delivery environment. The determined body shape can be used, for example, to generate a virtual fitting room user interface.

Classes IPC  ?

• G06N 3/08 - Méthodes d'apprentissage
• G06Q 50/00 - Technologies de l’information et de la communication [TIC] spécialement adaptées à la mise en œuvre des procédés d’affaires d’un secteur particulier d’activité économique, p. ex. aux services d’utilité publique ou au tourisme
• G06Q 30/06 - Transactions d’achat, de vente ou de crédit-bail
• G06T 19/00 - Transformation de modèles ou d'images tridimensionnels [3D] pour infographie

Abrégé

The present invention provides a method for detecting structural variations (SV) within genomes of single cells or population of single cells by integrating a three-layered information of sequencing read depth, read strand orientation and haplotype phase. The method of the invention can detect deletions, duplications, polyploidies, translocations, inversions, and copy number neutral loss of heterozygosity (CNN-LOH), and more. The method of the invention can fully karyotype a genome comprehensively, and may be applied in research and clinical approaches. For example, the methods of the invention are useful for analysing cellular samples of patients for diagnosing or aiding a diagnosis, in reproductive medicine to detect embryonic abnormalities, or during therapeutic approaches based on cellular therapies to quality control genetically engineered cells, such as in adoptive T cell therapy and others. The method of the invention may further be applied in research to decipher the karyotypes of cellular models (cell lines), patient samples, or to further unravel genetic and mechanistic pathways leading to the generation of any SV within genomes.

Classes IPC  ?

• G16B 20/20 - Détection d’allèles ou de variantes, p. ex. détection de polymorphisme d’un seul nucléotide
• G16B 30/00 - TIC spécialement adaptées à l’analyse de séquences impliquant des nucléotides ou des aminoacides
• G16B 50/00 - TIC pour la programmation d’outils ou de systèmes de bases de données spécialement adaptées à la bio-informatique

Abrégé

A particle testing apparatus, being configured for investigating particles in a fluid medium, includes a waveguide device having a hollow optical waveguide with an input end and an output end, an irradiation device including a laser source being arranged for optically trapping at least one particle at the input end of the optical waveguide and propelling the particle through the optical waveguide toward the output end thereof, and a measuring device being arranged for sensing the at least one particle in the optical waveguide, wherein the measuring device is arranged for measuring an optical transmission of the optical waveguide. Furthermore, a particle testing apparatus is described.

Classes IPC  ?

• G01N 15/02 - Recherche de la dimension ou de la distribution des dimensions des particules
• G01N 1/22 - Dispositifs pour prélever des échantillons à l'état gazeux
• G01N 15/0205 - Recherche de la dimension ou de la distribution des dimensions des particules par des moyens optiques
• G01N 15/14 - Techniques de recherche optique, p. ex. cytométrie en flux
• G01N 15/1434 - Dispositions optiques
• G01N 15/00 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux

Abrégé

The present invention relates to an apparatus for sliding friction free and lubricant free movement in vacuum, wherein the apparatus has a fixed position rail and a rail movable relative thereto by means of magnetic force. The invention further relates to a vacuum chamber, for example for a coating plant having an apparatus in accordance with the invention.

Classes IPC  ?

• F16C 29/04 - Roulements à billes ou à rouleaux
• F16C 32/04 - Paliers non prévus ailleurs faisant usage de moyens de support magnétiques ou électriques

Abrégé

An interferometer apparatus includes a beam splitter arranged for splitting an input beam into a first beam propagating along a first interferometer arm including a deflection mirror and a second beam propagating along a second interferometer arm including a deflection mirror. The first and second interferometer arms have an identical optical path length. A beam combiner is arranged for recombining the first and second beams into a constructive output and a destructive output. In the first interferometer arm compared with the second interferometer arm, one additional Fresnel reflection at an optically dense medium is provided and a propagation of the electromagnetic fields of the first and second beams, when recombined by the beam combiner, results in a wavelength-independent phase difference of π between the contributions of the two interferometer arms to the destructive output. Furthermore, an interferometric measurement apparatus and an interferometric measurement method are described.

Classes IPC  ?

• G01B 9/02 - Interféromètres
• G02B 27/10 - Systèmes divisant ou combinant des faisceaux

Abrégé

Disclosed herein is an engineered lipid-based vesicle optionally used for delivery of one or more payloads. The vesicle comprises a nanotube dimer or complex embedded with a lipid bilayer of the lipid-based vesicle. Also described herein are compositions, e.g., pharmaceutical compositions, and kits comprising the engineered lipid-based vesicle. In additional embodiments, further described herein are use of the engineered lipid-based vesicle for treating a disease or condition, for delivery to a target, or for labeling of a cell.

Classes IPC  ?

• A61K 9/1271 - Liposomes non conventionnels, p. ex. liposomes modifiés par un PEG ou liposomes enduits de ou greffés avec des polymères
• A61K 31/65 - Tétracyclines

Abrégé

A classifying device for classifying cells in real-time, comprising: as alignment unit configured to align a cell to be classified along the cell's major axis; and a classifying unit configured to classify the aligned cell using a multilayer perceptron, MLP; wherein the MLP classifies the aligned cell based on one or more images of the aligned cell. By executing the classifying device, an improved and efficient cell classification in real-time based on cell images can be provided, while labelling of the cells to be classified can be avoided.

Classes IPC  ?

• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
• G01N 21/85 - Analyse des fluides ou solides granulés en mouvement
• G01N 33/487 - Analyse physique de matériau biologique de matériau biologique liquide
• G06K 9/62 - Méthodes ou dispositions pour la reconnaissance utilisant des moyens électroniques
• G06V 20/69 - Objets microscopiques, p. ex. cellules biologiques ou pièces cellulaires

Abrégé

A laser device (100), being configured for generating laser pulses by Ken lens based mode locking, comprises a laser resonator (10) with a plurality of resonator mirrors (11.1, 11.2, 11.3) spanning a resonator beam path (12), a solid state gain medium (20) being arranged in the laser resonator (10), a Kerr medium device (30) being arranged with a distance from the gain medium (20) in the laser resonator (10), wherein the Kerr medium device (30) includes at least one Ken medium being arranged in a focal range of the resonator beam path and being configured for forming the laser pulses by the nonlinear Kerr effect, and a loss-modulation device (31, 32) having a modulator medium, which is capable of modulating a power loss of the laser pulses generated in the laser resonator (10), wherein the Kerr medium device (30) includes the modulator medium of the loss-modulation device (31, 32) as the at least one Kerr medium having an optical non-linearity being adapted for both of creating the Kerr lens based mode-locking in the laser resonator and modulating the power loss in the laser resonator. Furthermore, a method of generating laser pulses by Kerr lens based mode locking is described, wherein a loss-modulation device (31, 32) is used for both of introducing a Ken effect in the laser resonator (10) and modulating the power loss.

Classes IPC  ?

• H01S 3/11 - Blocage de modesCommutation-QAutres techniques d'impulsions géantes, p. ex. vidange de cavité
• H01S 3/06 - Structure ou forme du milieu actif
• H01S 3/081 - Structure ou forme des résonateurs optiques ou de leurs composants comprenant trois réflecteurs ou plus
• H01S 3/107 - Commande de l'intensité, de la fréquence, de la phase, de la polarisation ou de la direction du rayonnement, p. ex. commutation, ouverture de porte, modulation ou démodulation par commande de dispositifs placés dans la cavité utilisant des dispositifs électro-optiques, p. ex. produisant un effet Pockels ou Kerr
• H01S 3/13 - Stabilisation de paramètres de sortie de laser, p. ex. fréquence ou amplitude
• H01S 3/136 - Stabilisation de paramètres de sortie de laser, p. ex. fréquence ou amplitude par commande de dispositifs placés dans la cavité

Abrégé

The present invention relates in a first aspect to a method for the purification of biological macromolecular complexes. Typically, no chromatography steps are applied. That is, the present invention relates to a method for the purification of biological macromolecular complexes Furthermore, the present invention relates to a method for crystallization of biological macromolecular complexes comprising the step of purification as described followed by crystallization in a reservoir solution containing a water-soluble polymer. Furthermore, purified biological macromolecular complexes obtainable by the method according to the present invention are provided as well as crystallized biological macromolecular complexes. Finally, a method for determining the suitability of a candidate compound for inhibiting the 20S proteasome of an individual is provided. Said method is particularly useful in personalized medicine identifying suitable inhibitors of the 20S proteasome in individuals for treating, ameliorating or preventing a cancer, an autoimmune disease, a muscular dystrophy, emphysema or cachexia accompanying cancer or AIDS.

Classes IPC  ?

• C07K 1/36 - ExtractionSéparationPurification par une combinaison de plusieurs procédés de types différents
• C07K 1/30 - ExtractionSéparationPurification par précipitation
• C07K 1/32 - ExtractionSéparationPurification par précipitation sous forme de complexes

Abrégé

Disclosed are a device, system and method for animal tracking. The tracking device comprises a tracker processing component, an energy component, a transmitting component, and a securing component. The system comprises the tracking device, a receiving device and a server. The method comprising securing the tracking device to an animal, transmitting an identification of the animal, receiving the transmission via the receiving device, modifying it and forwarding it to the server, where the modified transmission is logged and analyzed to determine animal positions.

Classes IPC  ?

• A01K 11/00 - Marquage des animaux
• H04W 4/029 - Services de gestion ou de suivi basés sur la localisation
• H04W 4/80 - Services utilisant la communication de courte portée, p. ex. la communication en champ proche, l'identification par radiofréquence ou la communication à faible consommation d’énergie
• A01K 29/00 - Autres appareils pour l'élevage
• G01S 5/00 - Localisation par coordination de plusieurs déterminations de direction ou de ligne de positionLocalisation par coordination de plusieurs déterminations de distance
• G01S 13/46 - Détermination indirecte des données relatives à la position

Abrégé

In a first aspect, the present invention relates to an isolated nucleic acid molecule, in particular, an RNA molecule containing particular substitutions. In a further aspect, the present invention relates to a composition comprising the same as well as virus-like particle, viral vector or virus particle containing the nucleic acid molecule according to the present invention. The virus-like particle, the viral vector or the virus particle is suitable for use as a medicament in particular for treating viral infection. Further, a pharmaceutical composition is provided in particular suitable for use as a pharmaceutical prophylactic vaccine containing the virus-like particle, viral vector or the virus particle or the nucleic acid molecule according to the present invention. Finally, a vaccine for vaccination against viral infection, in particular, influenza viral infection is provided as well as a composition or kit comprising the virus-like particle, viral vector or the virus particle according to the present invention or the nucleic acid molecule according to the present invention in a combination with a wild type viral vector or wild type virus particle said composition or kit is suitable for use in treating or protecting against viral infection.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 35/76 - VirusParticules sous-viralesBactériophages
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps

Abrégé

An apparatus and method for simultaneous imaging and execution of contact-free directed hydrodynamic flow in a specimen. The apparatus includes a laser adapted to dynamically heat the specimen, a microscope with an objective adapted to image at least a part of the specimen and to guide a light beam of the laser into and/or onto the specimen to heat at least one specified location of the specimen, means for manipulating the specified location, and a sample chamber for the specimen that is accessible for imaging radiation and the light beam to allow simultaneous imaging and manipulation of the sample via the objective.

Classes IPC  ?

• G02B 21/36 - Microscopes aménagés pour la photographie ou la projection
• G02B 21/02 - Objectifs
• G02B 21/08 - Condensateurs
• G02B 21/28 - Structure du bâti ou statif avec dispositif de réfrigération
• G02B 21/30 - Structure du bâti ou statif avec dispositif de réchauffage
• G01N 21/64 - FluorescencePhosphorescence
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
• G02B 21/00 - Microscopes
• G01N 15/00 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux

Abrégé

A neutrino detector device (100) for detecting neutrinos comprises at least one target detector (10) including a target crystal (11) for creating phonons in response to an interaction of neutrinos to be detected with the target crystal (11) and a target temperature sensor (12) for sensing a temperature change in response to an absorption of phonons created in the target crystal (11), an inner veto detector (20) comprising at least one inner veto component (21) with an inner veto temperature sensor (23), wherein the at least one inner veto component (21) is adapted for supporting the at least one target detector (10) and for an anticoincidence based discrimination of alpha and beta background interaction events by creating phonons in response to the background interaction events and sensing a temperature change in response to an absorption of the phonons with the inner veto temperature sensor (23), and an outer veto detector (30) for accommodating the inner veto detector (20), wherein the outer veto detector (30) comprises at least one outer veto component (31) creating phonons in response to an interaction with gamma and neutron background and having an outer veto temperature sensor (33) for sensing a temperature change in response to an absorption of phonons created in the at least one outer veto component (31), wherein the neutrino detector device (100) is configured for an operation at cryogenic temperatures, a crystal volume of the target crystal (11) and a size of the target temperature sensor (12) of the at least one target detector (10) are selected such that an over-ground sensitivity threshold of the at least one target detector (10) is below 180 eV, and the at least one inner veto component (21, 26) surrounds the at least one target detector (10), so that the at least one target detector (10) is arranged within the inner veto detector (20). Furthermore, a neutrino detector system including the neutrino detector device and methods of detecting neutrinos are described, wherein the neutrino detector device (100) is used.

Classes IPC  ?

• G01T 1/36 - Mesure de la distribution spectrale des rayons X ou d'une radiation nucléaire
• G01T 1/16 - Mesure de l'intensité de radiation
• G01T 1/38 - Discrimination des particules et mesure des masses relatives, p. ex. par mesure de la perte d'énergie avec la distance (dE/dx)

Abrégé

For comparing first optical properties of a first fluid with second optical properties of a second fluid a first transparent grating having a grating constant is made of the first liquid, and a second transparent grating also having the grating constant is made of the second liquid. The second transparent grating is arranged at a lateral offset of less than 45% of the grating constant with regard to the first transparent grating such that grating bars of the first and second transparent gratings are arranged side by side. Coherent light is directed onto the first and second transparent gratings such that light which passed through the grating bars of the first and second transparent gratings forms a diffraction pattern comprising intensity maxima. Two light intensities of two intensity maxima of a same order higher than zero are measured and compared to each other.

Classes IPC  ?

• G01N 21/41 - RéfringencePropriétés liées à la phase, p. ex. longueur du chemin optique
• G02B 5/18 - Grilles de diffraction

Abrégé

A magnetic closure device has two complementary magnetic closure elements. Each of the two complementary magnetic closure elements includes an elongated magnet carrier having a single direction of main extension, and a plurality of permanent magnets supported by the magnet carrier in defined positions along the direction of main extension. Each of the permanent magnets is permanently magnetized either longitudinally or diametrically with regard to the direction of main extension. The permanent magnets following to each other in the direction of main extension are arranged in a closure alignment pattern having a magnetic non-repetition length extending over three or more of the permanent magnets. The magnet carrier is bendable in at least one direction orthogonal to the direction of main extension.

Classes IPC  ?

• H01F 7/02 - Aimants permanents
• A41F 1/00 - Dispositifs d'attache spécialement adaptés aux vêtements
• B65D 33/24 - Dispositifs de fermeture de l'extrémité ou de l'ouverture utilisant des éléments de fermeture à emboîtage formant corps ou rapportés, p. ex. pattes

Abrégé

The present disclosure relates to an apparatus and methods for applying a force on a sample. In particular, the present disclosure relates to a stress cell (200) comprising a frame (205); an actuator arrangement (210) coupled to the frame; and a coupler (220) for coupling the actuator arrangement to the sample (230). The coupler (220) includes a first coupler portion connected to the actuator arrangement (210) and a second coupler portion connectable to the sample (230). The first coupler portion is flexibly coupled to the frame. The actuator arrangement (210) comprises a first element (214) having a first variable length and a second element (212) having a second variable length, and is adapted to vary a difference between the first length and the second length to provide the force.

Classes IPC  ?

• G01N 3/18 - Exécution de tests à des températures élevées ou basses

Abrégé

A pulse laser apparatus (100) for creating laser pulses (1), in particular soliton laser pulses (1), based on Kerr lens mode locking of a circulating light field in an oscillator cavity (10), comprises at least two resonator mirrors (11, 12, . . . ) spanning a resonator beam path (2) of the oscillator cavity (10), at least one Kerr-medium (21, 22, 23) for introducing self-phase modulation and self-focusing to the circulating light field in the oscillator cavity (10), at least one gain-medium (31) for amplifying the circulating light field in the oscillator cavity (10), and a tuning device (40) for setting a first mode-locking condition and a second mode-locking condition of the oscillator cavity (10) such that an intra-cavity threshold-power for mode-locking at the first mode-locking condition is lower than that at the second mode-locking condition, wherein the first mode-locking condition is adapted for starting or shutting-down of the Kerr lens mode locking and the second mode-locking condition is adapted for continuous Kerr lens mode locking and a resonator-internal peak-power of the circulating light field is higher at the second mode-locking condition than at the first mode-locking condition. Furthermore, a method of operating a pulse laser apparatus is described.

Classes IPC  ?

• H01S 3/098 - Accrochage de modes; Suppression de modes
• H01S 3/11 - Blocage de modesCommutation-QAutres techniques d'impulsions géantes, p. ex. vidange de cavité
• H01S 3/06 - Structure ou forme du milieu actif
• H01S 3/08 - Structure ou forme des résonateurs optiques ou de leurs composants
• H01S 3/081 - Structure ou forme des résonateurs optiques ou de leurs composants comprenant trois réflecteurs ou plus
• H01S 3/0941 - Procédés ou appareils pour l'excitation, p. ex. pompage utilisant le pompage optique par de la lumière cohérente produite par un laser à semi-conducteur, p. ex. par une diode laser
• H01S 3/10 - Commande de l'intensité, de la fréquence, de la phase, de la polarisation ou de la direction du rayonnement, p. ex. commutation, ouverture de porte, modulation ou démodulation
• H01S 3/107 - Commande de l'intensité, de la fréquence, de la phase, de la polarisation ou de la direction du rayonnement, p. ex. commutation, ouverture de porte, modulation ou démodulation par commande de dispositifs placés dans la cavité utilisant des dispositifs électro-optiques, p. ex. produisant un effet Pockels ou Kerr
• H01S 3/109 - Multiplication de la fréquence, p. ex. génération d'harmoniques
• H01S 3/131 - Stabilisation de paramètres de sortie de laser, p. ex. fréquence ou amplitude par commande du milieu actif, p. ex. par commande des procédés ou des appareils pour l'excitation
• H01S 3/16 - Matériaux solides

Abrégé

Each of monodisperse spherical microcapsules for seeding a transparent fluid to track movements of the fluid both in translational and rotational directions comprises a core; a shell; and 1 to 5 light reflecting solid integral particles. Each of the particles reflects incoming light in a defined direction; and each of the particles is embedded in the core and fixed in its orientation with regard to the shell. The shell and the core are transparent for the incoming light to be reflected by the particles entering and exiting the microcapsule. The shell has a thickness of not more than λ, λ being a wavelength of the incoming light, so that the shell does essentially not deflect the incoming light entering and exiting the microcapsule. The core includes a main component of the fluid such that a refraction index of the core essentially matches a refraction index of the fluid.

Classes IPC  ?

• B01J 13/16 - Polymérisation interfaciale
• C08G 18/64 - Composés macromoléculaires non prévus dans les groupes
• C08K 3/22 - OxydesHydroxydes de métaux
• G01N 21/53 - Dispersion, c.-à-d. réflexion diffuse dans un corps ou dans un fluide dans un courant de fluide, p. ex. dans la fumée
• C08G 18/76 - Polyisocyanates ou polyisothiocyanates cycliques aromatiques
• C08K 3/36 - Silice
• C08K 9/02 - Ingrédients traités par des substances inorganiques

Abrégé

This invention relates to extracellular protein-protein interactions and their possible therapeutic uses. More particularly, this invention describes the interaction between Draxin, particularly fragments binding to γ-Netrins comprising SEQ ID NO.:1, 2 or 3, and variants thereof, with γ-Netrins, and the use of this interaction to disrupt γ-Netrin/Netrin receptor interactions. The invention also relates to diagnostic and/or therapeutic uses of Draxin or fragments or variants thereof, as well as to an antibody against Draxin inhibiting binding of Draxin to γ-Netrins. Further, the invention relates to fragments of γ-Netrins, in particular Draxin-binding Netrin1-fragments comprising SEQ ID NO.: 51 and variants thereof, as well as to an antibody against γ-Netrins inhibiting binding of γ-Netrins to Netrin receptors.

Classes IPC  ?

• C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
• C07K 14/475 - Facteurs de croissanceRégulateurs de croissance
• C07K 14/46 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés
• C07K 16/18 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains
• A61K 38/00 - Préparations médicinales contenant des peptides

Abrégé

The present invention relates to a method of actuating a shape changeable member of actuatable material. The invention further relates to a shape changeable member and to a system comprising such a shape changeable member and a magnetic field apparatus.

Classes IPC  ?

• H01F 1/03 - Aimants ou corps magnétiques, caractérisés par les matériaux magnétiques appropriésEmploi de matériaux spécifiés pour leurs propriétés magnétiques en matériaux inorganiques caractérisés par leur coercivité
• B81B 3/00 - Dispositifs comportant des éléments flexibles ou déformables, p. ex. comportant des membranes ou des lamelles élastiques
• F03G 7/06 - Mécanismes produisant une puissance mécanique, non prévus ailleurs ou utilisant une source d'énergie non prévue ailleurs utilisant la dilatation ou la contraction des corps produites par le chauffage, le refroidissement, l'humidification, le séchage ou par des phénomènes similaires
• B63H 1/37 - Propulseurs à mouvement ondulant, c.-à-d. comportant des moyens de propulsion comprenant une structure ondulante souple

Abrégé

GMF) (4) each comprising the difference of the sample and reference GMF waves. Furthermore, as a spectroscopic apparatus for measuring a polarization response of a sample (1) is described.

Classes IPC  ?

• G01N 21/21 - Propriétés affectant la polarisation
• G01N 21/3586 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge en utilisant la lumière de l'infrarouge lointainCouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge en utilisant un rayonnement térahertz par spectroscopie térahertz dans le domaine temporel [THz-TDS]
• G01N 21/45 - RéfringencePropriétés liées à la phase, p. ex. longueur du chemin optique en utilisant des méthodes interférométriquesRéfringencePropriétés liées à la phase, p. ex. longueur du chemin optique en utilisant les méthodes de Schlieren
• G01B 9/02 - Interféromètres
• G01N 21/65 - Diffusion de Raman

Abrégé

The invention relates in a first aspect to a process for preparing a 3-dimensional body, in particular a vitreous or ceramic body, which comprises at least the following steps: a) providing an electrostatically stabilized suspension of particles; b) effecting a local destabilization of the suspension of particles by means of a localized electrical discharge between a charge injector and the suspension at a predetermined position and causing an aggregation and precipitation of the particles at said position; c) repeating step b) at different positions and causing the formation of larger aggregates until a final aggregate of particles representing a (porous) 3-dimensional body (green body) having predetermined dimensions has been formed; wherein the charge injector includes i) at least one discharge electrode which does not contact said suspension of particles or ii) a source of charged particles. A second aspect of the invention relates to a device, in particular for performing the above process, comprising at least the following components: —a vessel for receiving an electrostatically stabilized suspension of particles, —a charge injector, in particular including one or more electrodes or a source of high-energy charged particles, —means for moving the electrode and/or the vessel in the x, y and z directions, —a counter electrode arranged in the vessel for a contact with the suspension of particles, —one or more sensors for determining geometrical and physical parameters within said vessel. In one preferred embodiment, said device further comprises a means for directing a beam of gas-ionizing radiation, in particular a laser beam, to a predetermined position within the vessel.

Classes IPC  ?

• B28B 1/00 - Fabrication d'objets façonnés à partir du matériau
• C03B 19/06 - Autres méthodes de façonnage du verre par frittage
• C04B 35/111 - Céramiques fines
• C04B 35/14 - Produits céramiques mis en forme, caractérisés par leur compositionCompositions céramiquesTraitement de poudres de composés inorganiques préalablement à la fabrication de produits céramiques à base d'oxydes à base de silice
• C04B 35/443 - Spinelle d'aluminate de magnésium
• C04B 35/46 - Produits céramiques mis en forme, caractérisés par leur compositionCompositions céramiquesTraitement de poudres de composés inorganiques préalablement à la fabrication de produits céramiques à base d'oxydes à base d'oxydes de titane ou de titanates
• C04B 35/565 - Produits céramiques mis en forme, caractérisés par leur compositionCompositions céramiquesTraitement de poudres de composés inorganiques préalablement à la fabrication de produits céramiques à base de non oxydes à base de carbures à base de carbure de silicium
• C04B 35/581 - Produits céramiques mis en forme, caractérisés par leur compositionCompositions céramiquesTraitement de poudres de composés inorganiques préalablement à la fabrication de produits céramiques à base de non oxydes à base de borures, nitrures ou siliciures à base de nitrure d'aluminium
• C04B 35/584 - Produits céramiques mis en forme, caractérisés par leur compositionCompositions céramiquesTraitement de poudres de composés inorganiques préalablement à la fabrication de produits céramiques à base de non oxydes à base de borures, nitrures ou siliciures à base de nitrure de silicium
• C04B 35/626 - Préparation ou traitement des poudres individuellement ou par fournées
• B33Y 10/00 - Procédés de fabrication additive
• B33Y 30/00 - Appareils pour la fabrication additiveLeurs parties constitutives ou accessoires à cet effet
• B33Y 80/00 - Produits obtenus par fabrication additive

Abrégé

An apparatus for terminating or unpinning rotating electric activity in a cardiac tissue analyzes an electric parameter for rotating electric activity in the cardiac tissue, and generates electric pulses in response to the rotating electric activity. The electric pulses are applied as electric field pulses and include a plurality of rotating electric activity synchronization pulses arranged at first intervals and a rotating electric activity termination or unpinning pulse following to the last synchronization pulse at a second interval which is similar to one of the first intervals. A maximum electric field strength caused the synchronization pulses is not more than 82% of a maximum electric field strength caused by the termination or unpinning pulse, and an electric pulse energy delivered to the cardiac tissue by each of the synchronization pulses is not more than 67% of an electric pulse energy delivered by the termination or unpinning pulse.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/362 - Stimulateurs cardiaques
• A61N 1/365 - Stimulateurs cardiaques commandés par un paramètre physiologique, p. ex. par le potentiel cardiaque
• A61N 1/39 - Défibrillateurs cardiaques

Abrégé

A method for forecasting an environmental event/a type of environmental event includes acquiring at least one test data set of at least one behavioural and/or physiological parameter of a population of animals; generating a test profile based on said at least one test data set, representing behaviour and/or physiological status of the population of animals; calculating a ratio between the test profile and a first reference profile; and setting an alert, if said ratio reaches a predefined threshold value.

Classes IPC  ?

• G01W 1/10 - Dispositifs pour la prévision des conditions météorologiques
• G01V 1/00 - SéismologieProspection ou détection sismique ou acoustique
• A61B 5/16 - Dispositifs pour la psychotechnieTest des temps de réaction
• A61B 5/0205 - Évaluation simultanée de l'état cardio-vasculaire et de l'état d'autres parties du corps, p. ex. de l'état cardiaque et respiratoire
• A61B 5/0476 - Electro-encéphalographie
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• G06Q 50/26 - Services gouvernementaux ou services publics

Abrégé

For spatial high resolution determining a position of a singularized molecule, which is excitable with excitation light for emission of luminescence light, in n spatial dimensions in a sample, the excitation light is directed onto the sample with an intensity distribution, which has a zero point and intensity increasing regions adjoining the zero point on both sides in each of the n spatial dimensions. The zero point is arranged at not more than n×3 different positions. The luminescence light emitted by the singularized molecule is separately registering for each of the different positions of the zero point. The position of the singularized molecule in the n spatial dimensions in the sample is deduced from intensities of the luminescence light separately registered for the not more than n×3 different positions of the zero point.

Classes IPC  ?

• G01N 21/64 - FluorescencePhosphorescence
• G02B 21/00 - Microscopes
• G02B 21/36 - Microscopes aménagés pour la photographie ou la projection

Abrégé

For spatial high resolution determining a position of a singularized molecule, which is excitable with excitation light for emission of luminescence light, in n spatial dimensions in a sample, a preliminary local area including the singularized molecule is determined The excitation light is directed onto the sample with an intensity distribution, which has a zero point and intensity increasing regions adjoining the zero point on both sides in each of the n spatial dimensions. At first, the zero point is arranged at preliminary positions on known sides of the preliminary local area. Then, present positions of the zero point are successively shifted into the preliminary local area in each of the n spatial dimensions depending on photons of the luminescence light which is quasi-simultaneously separately registered for the present positions of the zero point in that the zero point is repeatedly shifted between the present positions of the zero point.

Classes IPC  ?

• G01N 21/64 - FluorescencePhosphorescence
• G02B 21/00 - Microscopes
• G02B 21/36 - Microscopes aménagés pour la photographie ou la projection

Abrégé

For spatial high resolution determining a position of a singularized molecule, which is excitable with excitation light for emission of luminescence light, in a sample, the excitation light is provided with an intensity distribution comprising an intensity increasing region with a known strictly monotonic course of an intensity of the luminescence light over a distance of the singularized molecule to a model point of the intensity distribution. The model point is arranged at different preliminary positions such that the intensity increasing region extends over a preliminary local area of the sample including the singularized molecule. From intensity values including intensities of the luminescence light separately registered for the preliminary positions of the model point, a further local area is determined which includes the singularized molecule and which is smaller than the preliminary local area. These steps are repeated using the last further local area as the next preliminary local area.

Classes IPC  ?

• G01N 21/64 - FluorescencePhosphorescence
• G02B 21/00 - Microscopes
• G02B 21/36 - Microscopes aménagés pour la photographie ou la projection

Abrégé

The invention relates to mutant light-inducible ion channels having improved properties as compared to the parent channel, nucleic acid constructs encoding same, expression vectors carrying the nucleic acid construct, cells comprising the nucleic acid construct or expression vector, and their respective uses, as well as non-human animals comprising the mutant light-inducible ion channel, the nucleic acid construct or the expression vector as disclosed herein.

Classes IPC  ?

• C07K 14/705 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire
• C07K 14/405 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'algues
• A61P 27/02 - Agents ophtalmiques
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• C12N 5/079 - Cellules neurales
• C12N 15/86 - Vecteurs viraux
• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

A cohesive granular material comprises granules made of a stiff substance and having a grain size in the range from 55 μm to 2.0 mm; an elastomeric substance connecting the granules, a Young's modulus of the elastomeric substance being at maximum 0.5 times a Young's modulus of the stiff substance; and voids between the granules, the voids being interconnected and providing a fluid permeability to the cohesive granular material.

Classes IPC  ?

• C04B 38/00 - Mortiers, béton, pierre artificielle ou articles de céramiques poreuxLeur préparation
• B01D 39/16 - Autres substances filtrantes autoportantes en substance organique, p. ex. fibres synthétiques
• B01D 39/20 - Autres substances filtrantes autoportantes en substance inorganique, p. ex. papier d'amiante ou substance filtrante métallique faite de fils métalliques non-tissés
• B01D 69/14 - Membranes dynamiques
• B01D 71/02 - Matériaux inorganiques
• B01D 71/70 - Polymères contenant, dans la chaîne principale, uniquement du silicium, avec ou sans soufre, azote, oxygène ou carbone
• C08K 3/40 - Verre
• C04B 111/00 - Fonction, propriétés ou utilisation des mortiers, du béton ou de la pierre artificielle

Abrégé

A spatio-temporally light modulated imaging system for confocal imaging an object includes a light modulating micro-mirror device, an imaging optic, and a camera device, wherein a carrier wheel device is provided for carrying multiple pairs of first and second dichroic beam splitters and multiple pairs of first and second emission filters, wherein the carrier wheel device is adjustable in multiple operational positions relative to the first and second optical axes, and wherein a casing is provided. Furthermore, a carrier wheel device for carrying optical members and a method for confocal imaging an object are disclosed.

Classes IPC  ?

• G02B 26/00 - Dispositifs ou dispositions optiques pour la commande de la lumière utilisant des éléments optiques mobiles ou déformables
• G02B 7/00 - Montures, moyens de réglage ou raccords étanches à la lumière pour éléments optiques
• G02B 21/00 - Microscopes
• G02B 26/08 - Dispositifs ou dispositions optiques pour la commande de la lumière utilisant des éléments optiques mobiles ou déformables pour commander la direction de la lumière
• G02B 27/10 - Systèmes divisant ou combinant des faisceaux

Abrégé

A spatio-temporally light modulated imaging system and method for confocal imaging an object is disclosed. The imaging system may include a light modulating micro-mirror device with an array of mirror elements, an imaging optic for focusing illumination light from the micro-mirror device onto the object and directing detection light created in the object in response to the illumination light towards the micro-mirror device, and a camera device with a detector camera for collecting the detection light travelling via the mirror elements and a first optical relaying device on a first optical axis, and for collecting the detection light travelling via the mirror elements and a second optical relaying device on a second optical axis, wherein a camera body of the detector camera is arranged with a vertical camera axis, and a deflecting mirror is arranged for deflecting the detection light from the optical axes to the vertical camera axis.

Classes IPC  ?

• G02B 21/00 - Microscopes
• G02B 7/22 - Raccords extensibles, p. ex. soufflets
• G02B 21/36 - Microscopes aménagés pour la photographie ou la projection

Abrégé

In a first aspect, the present invention relates to a method for the purification of virus compositions as well as biological macromolecular compounds in a sample comprising mixing the sample with osmolytes, like non-ionic organic polymers and contacting the mixed sample with a hydrophilic membrane, optionally washing the membrane, and eluting the virus preparations or biological macromolecular components from the membrane with an eluting solution containing reduced amounts or no osmolytes, like non-ionic organic polymer. Moreover, virus compositions and biological macromolecular components obtainable with the method according to the present invention are provided as well as the use of the method according to the present invention for purification of virus compositions including whole virus particles and virus-like particles or biological macromolecular components.

Classes IPC  ?

• C12N 7/00 - Virus, p. ex. bactériophagesCompositions les contenantLeur préparation ou purification

Abrégé

For measuring rheological properties of a liquid sample, the sample is attached to two sample attachment surfaces opposing each other in a pulling direction. The sample attachment surfaces and the liquid sample attached thereto are arranged in a field of view of a light microscope and imaged onto an electronic camera by means of an objective lens of the light microscope. One of the two sample attachment surfaces is pulled away from the other one in the pulling direction, while a plurality of images of the sample attachment surfaces and the sample attached thereto are registered with the camera. For different distances of the two sample attachment surfaces, both a diameter of the liquid sample in a middle between the two sample attachment surfaces and the respective distances of the two sample attachment surfaces are determined from the images registered with the electronic camera during the step of pulling.

Classes IPC  ?

• G01N 11/00 - Recherche des propriétés d'écoulement des matériaux, p. ex. la viscosité, la plasticitéAnalyse des matériaux en déterminant les propriétés d'écoulement
• G01N 13/02 - Recherche de la tension superficielle des liquides

Abrégé

For high spatial resolution imaging a structure marked with luminescence markers, light that has an effect on the emission of luminescence light by the luminescence markers is directed onto a sample with an intensity distribution having a central zero point. Scan areas of the sample are scanned with the zero point. Luminescence light emitted out of a local area including the zero point is registered and assigned to the respective location of the zero point in the sample. Several copies of an object of interest are arranged in the scan areas and subjected to varying surrounding conditions. The individual scan areas are scanned with the respective zero point at least two times at two different stages of reactions to the varying surrounding conditions. Dimensions of the scan areas are limited such that they are not larger than 75% of a distance of intensity maxima delimiting the zero point.

Classes IPC  ?

• G01N 21/64 - FluorescencePhosphorescence
• G02B 21/00 - Microscopes
• G02B 27/58 - Optique pour l'apodisation ou la super-résolvanceSystèmes optiques à ouverture synthétisée
• G01N 21/75 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé

Abrégé

An apparatus for applying at least one electric pulse to a living myocardial tissue comprises an input configured to receive an electric signal representing a present electric activity of the myocardial tissue; a signal processor configured to process the electric signal to calculate a present permutation value of the electric signal in the state space and to only output a control signal when the calculated present entropy value of the electric signal is lower than a predetermined entropy threshold value; a pulse generator configured to generate the at least one electric pulse in response to the control signal; and an output configured to output the at least one electric pulse to the myocardial tissue.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/362 - Stimulateurs cardiaques
• A61B 5/04 - Mesure de signaux bioélectriques du corps ou de parties de celui-ci
• A61B 5/0464 - Détection de la tachycardie ou de la bradycardie
• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
• A61N 1/365 - Stimulateurs cardiaques commandés par un paramètre physiologique, p. ex. par le potentiel cardiaque
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61N 1/37 - SurveillanceProtection

Abrégé

An emission lifetime measuring method, in particular for measuring a mean lifetime of electronically excited states of a sample, comprises the steps of illuminating the sample with at least one excitation light pulse, time-resolved detecting an emission response from the sample and creating a temporal detector response function, and calculating the mean lifetime of the electronically excited states on the basis of the detector response function, wherein the at least one excitation light pulse is shaped such that the sample achieves an equilibrium excited steady-state including a linearly increasing or constant number of the electronically excited states, the detector response function has a linear response function section with a constant slope, and the mean lifetime (τ) of the electronically excited states is calculated on the basis of at least one of a time position of the linear response function section relative to a reference time of the at least one excitation light pulse and the slope of the linear response function section. Furthermore, an emission lifetime measuring apparatus (100) is described.

Classes IPC  ?

• G01N 21/64 - FluorescencePhosphorescence

Abrégé

An ultrasonic apparatus (100) for creating a holographic ultrasound field (1) comprises an ultrasound source device (10) being adapted for creating an ultrasound wave, and a transmission hologram device (20) having a transmission hologram (21) and an exposed acoustic emitter surface (22), said transmission hologram device (20) being acoustically coupled with the ultrasound source device (10) and being arranged for transmitting the ultrasound wave through the acoustic emitter surface (22) and creating the holographic ultrasound field in a surrounding space, wherein the acoustic emitter surface (22) is a smooth surface which do not influence the field distribution of the ultrasound wave. Furthermore, a method of creating a holographic ultrasound field in an object (3), wherein the ultrasonic apparatus (100) is used, and applications of the ultrasonic apparatus (100) are described.

Classes IPC  ?

• G03H 1/08 - Procédés ou appareils pour produire des hologrammes pour faire des hologrammes synthétiques
• A61B 90/98 - Moyens d’identification pour les patients ou les instruments, p. ex. étiquettes utilisant des moyens électromagnétiques, p. ex. transpondeurs
• G01N 29/06 - Visualisation de l'intérieur, p. ex. microscopie acoustique
• G02B 5/32 - Hologrammes utilisés comme éléments optiques
• G03H 3/00 - Procédés ou appareils holographiques utilisant des ondes ultrasonores, sonores ou infrasonores pour obtenir des hologrammesProcédés ou appareils pour en obtenir une image optique
• G01N 29/24 - Sondes
• G03H 1/02 - Procédés ou appareils holographiques utilisant la lumière, les infrarouges ou les ultraviolets pour obtenir des hologrammes ou pour en obtenir une imageLeurs détails spécifiques Détails
• A61N 7/02 - Hyperthermie localisée par ultrasons
• A61N 7/00 - Thérapie par ultrasons
• A61B 90/90 - Moyens d’identification pour les patients ou les instruments, p. ex. étiquettes
• G03H 1/00 - Procédés ou appareils holographiques utilisant la lumière, les infrarouges ou les ultraviolets pour obtenir des hologrammes ou pour en obtenir une imageLeurs détails spécifiques
• G03H 1/04 - Procédés ou appareils pour produire des hologrammes
• G03H 1/22 - Procédés ou appareils pour obtenir une image optique à partir d'un hologramme
• A61B 17/22 - Instruments pour comprimer les ulcères ou similaires placés sur les organes internes du corpsInstruments pour curer les cavités des organes du corps, p. ex. des osInstruments, dispositifs ou procédés chirurgicaux pour l'élimination ou la destruction invasives des calculs utilisant des vibrations mécaniquesInstruments, dispositifs ou procédés chirurgicaux pour l'élimination non prévue ailleurs des obstructions dans les vaisseaux sanguins

Abrégé

Disclosed is an apparatus having a rotatable wheel with a planar external circumferential surface, which is flat in a direction parallel to the axis of rotation of the wheel, at least one nozzle having a nozzle opening for directing a molten metal onto the circumferential surface and a collection means for collecting solidified fibers of metal formed on the circumferential surface from the molten metal and separated from the circumferential surface by centrifugal force generated by rotation of the wheel. The nozzle has a rectangular cross-section having a width of the nozzle opening in the circumferential direction of rotation of the wheel and a length transverse to the circumferential surface of the wheel which is greater than the width. An apparatus is provided for controlling a gas pressure applied to the liquid metal and delivers it to the circumferential surface of the rotatable wheel.

Classes IPC  ?

• B22D 11/06 - Coulée continue des métaux, c.-à-d. en longueur indéfinie dans des moules dont les parois se déplacent, p. ex. entre des rouleaux, des plaques, des courroies, des chenilles
• B22D 11/16 - Commande ou régulation des opérations ou du fonctionnement

Abrégé

n,m), resp., and subjecting the rescaled coefficient data sets to a wavelet reconstruction Formula (IV) (S25) for providing the denoised MR images.

Classes IPC  ?

• G06K 9/00 - Méthodes ou dispositions pour la lecture ou la reconnaissance de caractères imprimés ou écrits ou pour la reconnaissance de formes, p.ex. d'empreintes digitales
• G06T 11/00 - Génération d'images bidimensionnelles [2D]
• G01R 33/56 - Amélioration ou correction de l'image, p. ex. par des techniques de soustraction ou d'établissement de moyenne
• G06T 5/00 - Amélioration ou restauration d'image
• G06T 5/10 - Amélioration ou restauration d'image utilisant le filtrage dans le domaine non spatial
• A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• G01R 33/565 - Correction de distorsions d'image, p. ex. dues à des inhomogénéités de champ magnétique
• G06T 3/00 - Transformations géométriques de l'image dans le plan de l'image

Abrégé

The present invention relates to a laser surgery apparatus for contact laser surgery and to a method of using the laser surgery apparatus. The laser surgery apparatus (1) comprises a contact laser scalpel (3) for contact laser surgery, the contact laser scalpel (4) comprising an optical fiber (4) of IR laser radiation transmissive material and terminating at an optical fiber tip (5) having an exposed core region, and support means for holding said fiber and for positioning said scalpel (3). Said fiber tip (5) is tapered and disposed at a distal end of the scalpel (3) for contacting a tissue to be cut and comprises an uncoated contact surface (6) for transmit ting laser radiation and a guiding surface that is at least partially reflective to laser radiation and provided such that laser radiation guided by said optical fiber (4) to said fiber tip (5) will be at least partially reflected by said guiding surface and emitted through said uncoated contact surface. The contact laser surgery apparatus further comprises a pulsed laser source (2) adapted to provide pulse durations in the femtosecond, picosecond and/or nanosecond range, and light transmitting means (9) connecting said laser source (2) to said optical fiber (4) of said scalpel (3) for conveying laser radiation from said laser source (2) to said optical fiber (4) such that the conveyed laser light is emitted at said uncoated contact surface of the fiber tip.

Classes IPC  ?

• A61B 18/20 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par application de radiations électromagnétiques, p. ex. de micro-ondes en utilisant des lasers
• A61F 9/008 - Procédés ou dispositifs pour la chirurgie de l'œil utilisant un laser
• A61N 5/06 - Thérapie par radiations utilisant un rayonnement lumineux
• A61F 9/009 - Dispositifs auxiliaires destinés à réaliser un contact avec le globe oculaire et un couplage de la lumière laser
• A61B 18/22 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par application de radiations électromagnétiques, p. ex. de micro-ondes en utilisant des lasers le faisceau étant dirigé le long, ou à l'intérieur d'un conduit flexible, p. ex. d'une fibre optiquePièces à main à cet effet
• A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
• A61N 5/067 - Thérapie par radiations utilisant un rayonnement lumineux utilisant un rayonnement laser
• A61B 17/3211 - Scalpels chirurgicaux ou bistourisLeurs accessoires

Abrégé

A method of measuring a spectral response of a biological sample (1), comprises the steps generation of probe light having a primary spectrum, irradiation of the sample (1) with the probe light, including an interaction of the probe light and the sample (1), and spectrally resolved detection of the probe light having a modified spectrum, which deviates from the primary spectrum as a result of the interaction of the probe light and the sample (1), said modified spectrum being characteristic of the spectral response of the sample (1), wherein the probe light comprises probe light pulses (2) being generated with a fs laser source device (10). Furthermore, a spectroscopic measuring apparatus is described, which is configured for measuring a spectral response of a biological sample (1).

Classes IPC  ?

• G01J 3/00 - SpectrométrieSpectrophotométrieMonochromateursMesure de la couleur
• G01N 21/35 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge
• C07D 231/12 - Composés hétérocycliques contenant des cycles diazole-1, 2 ou diazole-1, 2 hydrogéné non condensés avec d'autres cycles comportant deux ou trois liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec uniquement des atomes d'hydrogène, des radicaux hydrocarbonés ou des radicaux hydrocarbonés substitués, liés directement aux atomes de carbone du cycle
• G01N 21/3586 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge en utilisant la lumière de l'infrarouge lointainCouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge en utilisant un rayonnement térahertz par spectroscopie térahertz dans le domaine temporel [THz-TDS]

Abrégé

A method of fabricating a component (1) comprises the steps of providing precursor material in a working medium, creating acoustic forces and positioning the precursor material in the working medium under the effect of the acoustic forces, so that a material distribution is formed, which has a shape of the component to be fabricated, and subjecting at least one of the material distribution and the working medium to a fixation, so that the precursor material of the material distribution or the working medium surrounding the material distribution is bound, wherein the step of creating the acoustic forces includes generating an acoustic interference pattern (5), and the material distribution (4) is formed by moving the precursor material (2) towards energy extrema of the acoustic interference pattern (5). Furthermore, an apparatus (100) for fabricating a component (1) is described.

Classes IPC  ?

• B29C 64/165 - Procédés de fabrication additive utilisant une combinaison de matériaux solides et liquides, p. ex. une poudre avec liaison sélective par liant liquide, catalyseur, inhibiteur ou absorbeur d’énergie
• G03H 1/02 - Procédés ou appareils holographiques utilisant la lumière, les infrarouges ou les ultraviolets pour obtenir des hologrammes ou pour en obtenir une imageLeurs détails spécifiques Détails
• G03H 1/08 - Procédés ou appareils pour produire des hologrammes pour faire des hologrammes synthétiques
• G03H 3/00 - Procédés ou appareils holographiques utilisant des ondes ultrasonores, sonores ou infrasonores pour obtenir des hologrammesProcédés ou appareils pour en obtenir une image optique
• B29C 64/264 - Agencements pour irradiation
• B29C 64/236 - Moyens d’entraînement pour un mouvement dans une direction dans le plan d’une couche
• G03H 1/00 - Procédés ou appareils holographiques utilisant la lumière, les infrarouges ou les ultraviolets pour obtenir des hologrammes ou pour en obtenir une imageLeurs détails spécifiques
• G03H 1/22 - Procédés ou appareils pour obtenir une image optique à partir d'un hologramme

Abrégé

The invention relates to new conjugated semiconducting polymers containing thermally cleavable side groups. The thermally cleavable side groups are selected from among carbonate groups and carbamate groups. By thermally cleaving side groups, the solubility or the polymers can be reduced in a targeted manner. The polymers are used as semiconductors in organic electronic (OE) devices, especially in organic photovoltaic (OPV) devices, organic photodetectors (OPDs), organic light emitting diodes (OLEDs), and organic field effect transistors (OFETs).

Classes IPC  ?

• C08K 3/04 - Carbone
• H01M 4/60 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs de composés organiques
• H01L 51/00 - Dispositifs à l'état solide qui utilisent des matériaux organiques comme partie active, ou qui utilisent comme partie active une combinaison de matériaux organiques et d'autres matériaux; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de tels dispositifs ou de leurs parties constitutives
• C08G 61/12 - Composés macromoléculaires contenant d'autres atomes que le carbone dans la chaîne principale de la macromolécule
• C07D 333/16 - Radicaux substitués par des hétéro-atomes, autres que les halogènes, liés par des liaisons simples par des atomes d'oxygène
• C08L 65/00 - Compositions contenant des composés macromoléculaires obtenus par des réactions créant une liaison carbone-carbone dans la chaîne principaleCompositions contenant des dérivés de tels polymères
• C07D 285/10 - Thiadiazoles-1, 2, 5Thiadiazoles-1, 2, 5 hydrogénés
• C07D 471/06 - Systèmes condensés en péri
• C07D 209/86 - CarbazolesCarbazoles hydrogénés avec uniquement des atomes d'hydrogène, des radicaux hydrocarbonés ou des radicaux hydrocarbonés substitués, liés directement aux atomes de carbone du système cyclique
• C08G 61/10 - Composés macromoléculaires contenant uniquement des atomes de carbone dans la chaîne principale de la molécule, p. ex. polyxylylènes uniquement des atomes de carbone aromatiques, p. ex. polyphénylènes
• C12Q 1/6869 - Méthodes de séquençage
• H01L 51/05 - Dispositifs à l'état solide qui utilisent des matériaux organiques comme partie active, ou qui utilisent comme partie active une combinaison de matériaux organiques et d'autres matériaux; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de tels dispositifs ou de leurs parties constitutives spécialement adaptés au redressement, à l'amplification, à la génération d'oscillations ou à la commutation et ayant au moins une barrière de potentiel ou une barrière de surface; Condensateurs ou résistances à l'état solide, ayant au moins une barrière de potentiel ou une barrière de surface
• H01L 51/42 - Dispositifs à l'état solide qui utilisent des matériaux organiques comme partie active, ou qui utilisent comme partie active une combinaison de matériaux organiques et d'autres matériaux; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de tels dispositifs ou de leurs parties constitutives spécialement adaptés, soit comme convertisseurs de l'énergie dudit rayonnement en énergie électrique, soit comme dispositifs de commande de l'énergie électrique par ledit rayonnement
• H01L 51/50 - Dispositifs à l'état solide qui utilisent des matériaux organiques comme partie active, ou qui utilisent comme partie active une combinaison de matériaux organiques et d'autres matériaux; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de tels dispositifs ou de leurs parties constitutives spécialement adaptés pour l'émission de lumière, p.ex. diodes émettrices de lumière organiques (OLED) ou dispositifs émetteurs de lumière à base de polymères (PLED)
• H01L 51/52 - Dispositifs à l'état solide qui utilisent des matériaux organiques comme partie active, ou qui utilisent comme partie active une combinaison de matériaux organiques et d'autres matériaux; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de tels dispositifs ou de leurs parties constitutives spécialement adaptés pour l'émission de lumière, p.ex. diodes émettrices de lumière organiques (OLED) ou dispositifs émetteurs de lumière à base de polymères (PLED) - Détails des dispositifs

Abrégé

For characterizing spatial-temporal dynamics of a medium (1) excitable for deformation, an elastic model of the medium is defined. The medium is imaged at consecutive points in time to obtain a series of images. Shifts of structures of the medium (1) between the images of the series are determined. A dynamic description of a temporal development of spatial deformations of a predefined elastic model of the medium (1) is adapted to match the shifts of the structures; and temporal developments of rate of deformation patterns in the medium (1) are identified from the dynamic description.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• G16H 50/50 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour la simulation ou la modélisation des troubles médicaux
• A61B 8/08 - Applications cliniques
• A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
• A61B 5/04 - Mesure de signaux bioélectriques du corps ou de parties de celui-ci
• G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition

Abrégé

A method for providing a three-dimensional body model which may be applied for an animation, based on a moving body, wherein the method comprises providing a parametric three-dimensional body model, which allows shape and pose variations; applying a standard set of body markers; optimizing the set of body markers by generating an additional set of body markers and applying the same for providing 3D coordinate marker signals for capturing shape and pose of the body and dynamics of soft tissue; and automatically providing an animation by processing the 3D coordinate marker signals in order to provide a personalized three-dimensional body model, based on estimated shape and an estimated pose of the body by means of predicted marker locations.

Classes IPC  ?

• G06T 17/10 - Description de volumes, p. ex. de cylindres, de cubes ou utilisant la GSC [géométrie solide constructive]
• G06T 13/40 - Animation tridimensionnelle [3D] de personnages, p. ex. d’êtres humains, d’animaux ou d’êtres virtuels
• G06K 9/00 - Méthodes ou dispositions pour la lecture ou la reconnaissance de caractères imprimés ou écrits ou pour la reconnaissance de formes, p.ex. d'empreintes digitales
• G01B 11/25 - Dispositions pour la mesure caractérisées par l'utilisation de techniques optiques pour mesurer des contours ou des courbes en projetant un motif, p. ex. des franges de moiré, sur l'objet

Abrégé

18F]DCFPyL. The key advantages of these inventive methods are efficiency, short time of preparation and excellent amenability to automation. A pharmaceutical composition containing at least one PSMA-specific PET tracers prepared by the inventive method is useful for positron emission tomography (PET) imaging, especially imaging prostate tumor.

Classes IPC  ?

• C07D 213/82 - AmidesImides en position 3
• C07K 5/062 - Dipeptides la chaîne latérale du premier amino-acide étant acyclique, p. ex. Gly, Ala
• C07C 275/16 - Dérivés d'urée, c.-à-d. composés contenant l'un des groupes les atomes d'azote ne faisant pas partie de groupes nitro ou nitroso ayant des atomes d'azote de groupes urée liés à des atomes de carbone acycliques d'un squelette carboné acyclique et saturé étant substitué de plus par des groupes carboxyle
• C07K 1/13 - Marquage de peptides
• C07K 5/065 - Dipeptides la chaîne latérale du premier amino-acide contenant des carbocycles, p. ex. Phe, Tyr
• C07B 59/00 - Introduction d'isotopes d'éléments dans les composés organiques
• C07D 237/24 - Atomes de carbone comportant trois liaisons à des hétéro-atomes avec au plus une liaison à un halogène
• C07D 241/24 - Atomes de carbone comportant trois liaisons à des hétéro-atomes avec au plus une liaison à un halogène, p. ex. radicaux ester ou nitrile

Abrégé

A method of creating difference frequency (DF) laser pulses (1) by difference frequency generation (DFG) comprises the steps of providing ultrashort laser pulses (2) having a spectral bandwidth corresponding to a Fourier limit of below 50 fs and containing first spectral components and second spectral components having larger frequencies than the first spectral components, and driving a DFG process by the ultrashort laser pulses (2) in an optically non-linear crystal (10), wherein the DF laser pulses (1) are generated in the crystal (10) by difference frequencies between the first and second spectral components, resp., said difference frequencies comprising third spectral components being lower in frequency than the first and second spectral components, wherein at least one enhancement cavity (20) with resonator mirrors (Mi1 to M14) spanning a beam path (22) is provided and the crystal (10) is placed in the beam path (22) of the enhancement cavity (20), the ultrashort laser pulses (2) are input coupled and coherently added in the at least one enhancement cavity (20), at least one circulating ultrashort laser pulse (3) is created in the at least one enhancement cavity (20), which drives the DFG process in the crystal (10) for generating the DF laser pulses (1), and the at least one enhancement cavity (20) is adapted for recycling the at least one ultrashort laser pulse (3) passing through the crystal (10). Furthermore, a photonic source (100) for creating DF laser pulses (1) is described, including one or more enhancement cavities.

Classes IPC  ?

• G02F 1/35 - Optique non linéaire

Abrégé

2/W. A resonator device including the optical component, a method of modulating a light field using the optical component and a method of manufacturing the optical component are described.

Classes IPC  ?

• G02F 1/01 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p. ex. commutation, ouverture de porte ou modulationOptique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur
• G02F 1/35 - Optique non linéaire
• G02F 1/21 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p. ex. commutation, ouverture de porte ou modulationOptique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur par interférence
• G02F 1/355 - Optique non linéaire caractérisée par les matériaux utilisés
• H01S 3/08 - Structure ou forme des résonateurs optiques ou de leurs composants
• H01S 3/11 - Blocage de modesCommutation-QAutres techniques d'impulsions géantes, p. ex. vidange de cavité

Abrégé

a monitoring device (36) configured to detect scattered light that is created by the illumination of the or each particle by the guided light and that leaves the channel (32) by passing through the or each channel wall.

Classes IPC  ?

• G01N 15/14 - Techniques de recherche optique, p. ex. cytométrie en flux
• G01N 21/53 - Dispersion, c.-à-d. réflexion diffuse dans un corps ou dans un fluide dans un courant de fluide, p. ex. dans la fumée
• G01N 21/47 - Dispersion, c.-à-d. réflexion diffuse
• G01N 21/64 - FluorescencePhosphorescence
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
• G01N 15/00 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux

Abrégé

Apparatus for producing elongate strands of metal comprises a rotatable wheel having a circumferential surface, at least one nozzle for directing a molten metal onto the circumferential surface and a collection means for collecting solidified strands of metal formed. The solidified strands are formed on the circumferential surface from the molten metal and are separated from the circumferential surface by centrifugal force generated by rotation of the wheel. The circumferential surface has a circumferentially extending structure having circumferentially extending edges and recesses formed between or bounded by the edges, and by an apparatus for controlling a gas pressure applied to the liquid metal which moves the liquid metal through the nozzle opening and delivers it to the circumferential surface of the rotatable wheel. The nozzle has a rectangular cross-section with a width of the nozzle opening in the circumferential direction of rotation of the wheel and a length transverse to the circumferential surface of the wheel which is greater than the width. A method and a wheel adapted for use in the apparatus are also claimed.

Classes IPC  ?

• B22D 11/06 - Coulée continue des métaux, c.-à-d. en longueur indéfinie dans des moules dont les parois se déplacent, p. ex. entre des rouleaux, des plaques, des courroies, des chenilles
• B22D 11/00 - Coulée continue des métaux, c.-à-d. en longueur indéfinie

Abrégé

A method and an arrangement of spectrally broadening laser pulses for non-linear pulse compression is disclosed which is based on the transition from the spectral broadening in a waveguide to the spectral broadening in a suitably shaped lens conductor. The arrangement is non-sensitive with respect to the variations of the pulse power, the position and parameters of the laser beam. The spectrally broadened pulses can be compressed in a satisfactory manner and the quality of the laser beam maintained by dividing the non-linear phase required for spectral broadening into sufficiently smaller steps which can be separated without non-linearity by suitable prorogation. The limitation of the pulse powers to less than the critical power of dielectrics is thus overcome and a pulse energy range for which the spectral broadening in the glass fibers cannot be used, is developed. The arrangement can compress pulses having a large average power.

Classes IPC  ?

• G02F 1/35 - Optique non linéaire
• H01S 3/00 - Lasers, c.-à-d. dispositifs utilisant l'émission stimulée de rayonnement électromagnétique dans la gamme de l’infrarouge, du visible ou de l’ultraviolet
• G02F 2/02 - Changement de fréquence de la lumière, p. ex. par compteurs quantiques

Abrégé

For high spatial resolution imaging a structure in a sample, the structure being marked with luminescence markers, light that has an effect on the emission of luminescence light by the luminescence markers is directed onto the sample with an intensity distribution having a zero point and intensity maxima neighboring the zero point in at least one direction. A scan area which is a part of the sample is scanned with the zero point. Luminescence light emitted out of a local area including the zero point is registered and assigned to the respective location of the zero point in the sample. Dimensions of the scan area, in at least one direction in which the intensity maxima are neighboring the zero point, are limited such that they are not larger than 75% of a distance of the intensity maxima in the at least one direction.

Classes IPC  ?

• F21V 9/16 - Emploi de matériaux luminescents spécifiés comme écrans de lumière
• G02B 21/00 - Microscopes
• G01N 21/64 - FluorescencePhosphorescence
• G02B 21/16 - Microscopes adaptés pour éclairage ultraviolet
• G02B 27/58 - Optique pour l'apodisation ou la super-résolvanceSystèmes optiques à ouverture synthétisée

Abrégé

A magnetic closure device has two complementary magnetic closure elements. Each of the two complementary magnetic closure elements includes an elongated magnet carrier having a single direction of main extension, and a plurality of permanent magnets supported by the magnet carrier in defined positions along the direction of main extension. Each of the permanent magnets is permanently magnetized either longitudinally or diametrically with regard to the direction of main extension. The permanent magnets following to each other in the direction of main extension are arranged in a closure alignment pattern having a magnetic non-repetition length extending over three or more of the permanent magnets. The magnet carrier is bendable in at least one direction orthogonal to the direction of main extension.

Classes IPC  ?

• H01F 7/02 - Aimants permanents
• B65D 33/24 - Dispositifs de fermeture de l'extrémité ou de l'ouverture utilisant des éléments de fermeture à emboîtage formant corps ou rapportés, p. ex. pattes
• A41F 1/00 - Dispositifs d'attache spécialement adaptés aux vêtements

Abrégé

Provided are graphene nanoribbons with controlled zig-zag edge and cove edge configuration and methods for preparing such graphene nanoribbons. The nanoribbons are selected from the following formulae.

Classes IPC  ?

• C07C 25/22 - Hydrocarbures halogénés aromatiques polycycliques à cycles condensés
• C08G 61/10 - Composés macromoléculaires contenant uniquement des atomes de carbone dans la chaîne principale de la molécule, p. ex. polyxylylènes uniquement des atomes de carbone aromatiques, p. ex. polyphénylènes
• C07C 15/20 - Hydrocarbures polycycliques condensés
• C01B 32/184 - Préparation

Abrégé

A scanning luminescence light microscope for spatial high resolution imaging a structure marked with a luminescent marker comprises a light source for luminescence inhibition light and for further light; a light shaping and aligning device; and a detector registering luminescence light emitted by the luminescent marker. The device, by means of two optical gratings and an objective lens, forms two crossing line gratings of the luminescence inhibition light, and two crossing line gratings of the further light so that local intensity minima of an overall intensity distribution of the luminescence inhibition light are delimited in at least two directions, and that local intensity maxima or local intensity minima of an overall intensity distribution of the further light coincide with the local intensity minima of the luminescence inhibition light. Further, the device moves the overall intensity distributions of the further light and the luminescence inhibition light to scan the structure.

Classes IPC  ?

• G01N 21/64 - FluorescencePhosphorescence
• G02B 21/00 - Microscopes
• G02B 27/42 - Optique de diffraction
• G02B 27/58 - Optique pour l'apodisation ou la super-résolvanceSystèmes optiques à ouverture synthétisée
• G01N 21/63 - Systèmes dans lesquels le matériau analysé est excité de façon à ce qu'il émette de la lumière ou qu'il produise un changement de la longueur d'onde de la lumière incidente excité optiquement

Abrégé

This invention relates to extracellular protein-protein interactions and their possible therapeutic uses. More particularly, this invention describes the interaction between Draxin, particularly fragments binding to γ-Netrins comprising SEQ ID NO.: 1, 2 or 3, and variants thereof, with γ-Netrins, and the use of this interaction to disrupt γ-Netrin/Netrin receptor interactions. The invention also relates to diagnostic and/or therapeutic uses of Draxin or fragments or variants thereof, as well as to an antibody against Draxin inhibiting binding of Draxin to γ-Netrins. Further, the invention relates to fragments of γ-Netrins, in particular Draxin-binding Netrin1-fragments comprising SEQ ID NO.: 51 and variants thereof, as well as to an antibody against γ-Netrins inhibiting binding of γ-Netrins to Netrin receptors.

Classes IPC  ?

• C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
• C07K 14/475 - Facteurs de croissanceRégulateurs de croissance
• C07K 14/46 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés
• C07K 16/18 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains
• A61K 38/00 - Préparations médicinales contenant des peptides

Abrégé

A method of generating fs laser pulses (1), includes steps of creating a circulating light field in a resonator cavity (10) with multiple resonator mirrors (11-18) by pumping at least one gain medium (21, 22) included in the resonator cavity (10), and passing the circulating light field through a first Kerr medium (31) included in the resonator cavity (10), so that the fs laser pulses (1) are formed by self-amplitude modulation of the circulating light field, wherein the resonator cavity (10) includes at least one supplementary Kerr medium (32-36) enhancing the self-amplitude modulation of the circulating light field, and each of the first Kerr medium (31) and the at least one supplementary Kerr medium (32-36) provide different non-linear Kerr lens contributions to the self-amplitude modulation of the circulating light field. Laser pulse source apparatus (100) for generating fs laser pulses (1) is also described.

Classes IPC  ?

• H01S 3/10 - Commande de l'intensité, de la fréquence, de la phase, de la polarisation ou de la direction du rayonnement, p. ex. commutation, ouverture de porte, modulation ou démodulation
• H01S 3/109 - Multiplication de la fréquence, p. ex. génération d'harmoniques
• H01S 3/11 - Blocage de modesCommutation-QAutres techniques d'impulsions géantes, p. ex. vidange de cavité
• H01S 3/06 - Structure ou forme du milieu actif
• H01S 3/106 - Commande de l'intensité, de la fréquence, de la phase, de la polarisation ou de la direction du rayonnement, p. ex. commutation, ouverture de porte, modulation ou démodulation par commande de dispositifs placés dans la cavité
• H01S 3/08 - Structure ou forme des résonateurs optiques ou de leurs composants
• H01S 3/081 - Structure ou forme des résonateurs optiques ou de leurs composants comprenant trois réflecteurs ou plus
• H01S 3/16 - Matériaux solides

Abrégé

In order to determine the locations of individual fluorescent molecules in a sample, which keep a minimum distance with regard to each other, the individual molecules are excited for emission of fluorescence light by means of excitation light. The fluorescence light is registered for different positions of a zero point of an intensity distribution of the excitation light. The distance between these positions is at least half the minimum distance of the fluorescent molecules. The locations of the fluorescent molecules are derived from the course of the intensity of the fluorescence light over the positions of the zero point of the excitation light.

Classes IPC  ?

• G01N 21/64 - FluorescencePhosphorescence
• G01B 11/14 - Dispositions pour la mesure caractérisées par l'utilisation de techniques optiques pour mesurer la distance ou la marge entre des objets ou des ouvertures espacés
• G02B 21/00 - Microscopes
• G02B 21/16 - Microscopes adaptés pour éclairage ultraviolet
• G02B 21/36 - Microscopes aménagés pour la photographie ou la projection
• G02B 27/58 - Optique pour l'apodisation ou la super-résolvanceSystèmes optiques à ouverture synthétisée

Abrégé

Mycobacterium cell for use as a vaccine.

Classes IPC  ?

• A61K 39/02 - Antigènes bactériens
• A61K 39/04 - Mycobacterium, p. ex. Mycobacterium tuberculosis
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61K 39/38 - Antigènes de serpents
• A61K 45/00 - Préparations médicinales contenant des ingrédients actifs non prévus dans les groupes
• C12N 1/20 - BactériesLeurs milieux de culture
• C12N 1/12 - Algues unicellulairesLeurs milieux de culture
• C12N 15/74 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes procaryotes autres que E. coli, p. ex. Lactobacillus, Micromonospora
• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
• C07K 14/35 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries provenant de Mycobacteriaceae (F)
• A61K 38/00 - Préparations médicinales contenant des peptides

Abrégé

Ultrasonic actuator device (100) includes actuator arm arrangement (10) including first and second actuator sections (11,12), wherein the first section is arranged for coupling with support structure (50) and the second section is movable relative to the first section, and ultrasonic driver device (20) including at least one ultrasonic driver unit (21-28) coupled with at least one of first and second sections for driving actuator arm arrangement (10) and for providing movement of the second section relative to the first section, and wherein actuator arm arrangement (10) is movable with at least two degrees of freedom and the at least one ultrasonic driver unit includes an array of oscillating elements being arranged for creating an acoustic stream in an adjacent medium in response to application of ultrasound. Furthermore, an operational instrument including at least one ultrasonic actuator device (100) and a method of using the device are described.

Classes IPC  ?

• H02N 2/10 - Machines électriques en général utilisant l'effet piézo-électrique, l'électrostriction ou la magnétostriction produisant un mouvement rotatif, p. ex. moteurs rotatifs
• A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
• F03G 7/00 - Mécanismes produisant une puissance mécanique, non prévus ailleurs ou utilisant une source d'énergie non prévue ailleurs

Abrégé

For determining positions and orientations of mirrors, the mirrors are illuminated with parallel light rays. A first camera is arranged in an image plane onto which an objective images the mirrors. A second camera is arranged in a focal plane of the objective, and a third camera is arranged in an intermediate plane located at distances to both the image and the focal plane. At a same point in time, a first, a second and a third picture are taken with the first, the second and the third camera, respectively. The positions and the orientations of the mirrors are determined from light spots in the first and the second picture, respectively; and which of the orientations belongs to which of the positions is determined by correlating light spots in the third picture with both the light spots in the first and in the second picture.

Classes IPC  ?

• H04N 13/00 - Systèmes vidéo stéréoscopiquesSystèmes vidéo multi-vuesLeurs détails
• H04N 13/02 - Générateurs de signaux d'image
• H04N 17/00 - Diagnostic, test ou mesure, ou leurs détails, pour les systèmes de télévision
• G01B 11/00 - Dispositions pour la mesure caractérisées par l'utilisation de techniques optiques
• G06T 7/80 - Analyse des images capturées pour déterminer les paramètres de caméra intrinsèques ou extrinsèques, c.-à-d. étalonnage de caméra
• G06T 7/70 - Détermination de la position ou de l'orientation des objets ou des caméras

Abrégé

The present invention relates. to methods and devices for exchanging gas molecules between a gaseous medium and a liquid medium which are particularly suited for applications such as blood oxygenation in heart-lung machines and gas scrubbing. The method of the invention comprises the following steps: a) providing a liquid medium having a surface tension in the range of from 0.02 N/m to 0.06 N/m, b) providing a gaseous medium, c) providing a membrane on an interface between the liquid medium and the gaseous medium, wherein the membrane comprises i) a carrier substrate with through-going openings having a mean diameter in the range from 0.2 μιη to 200 μπι, and ii) a porous superamphiphobic coating layer with openings having a mean diameter in the range from 0.1 μm to 10 μm, which is provided at least on the substrate surface facing the liquid medium, wherein either the liquid medium or the gaseous medium, preferably the gaseous medium, comprises at least one target gas to be transferred and said membrane is permeable for the at least one gas to be transferred and not permeable for the liquid medium due to the super-amphiphobic properties of the membrane surface facing the liquid medium with respect to said liquid medium, d) contacting the gaseous medium with the liquid medium via said superamphiphobic layer for a sufficient time to enrich the liquid or gaseous target medium with the at least one gas to be transferred.

Classes IPC  ?

• A01N 1/02 - Conservation de parties vivantes
• B01F 3/04 - Mélange, p.ex. dispersion, émulsion, selon les phases à mélanger de gaz ou de vapeurs avec des liquides
• A61M 1/32 - Oxygénateurs sans membranes
• B01D 19/00 - Dégazage de liquides
• B01D 53/22 - Séparation de gaz ou de vapeursRécupération de vapeurs de solvants volatils dans les gazÉpuration chimique ou biologique des gaz résiduaires, p. ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par diffusion
• B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétésProcédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
• B01D 69/14 - Membranes dynamiques
• A61M 1/16 - Systèmes de dialyseReins artificielsOxygénateurs du sang avec membranes

Abrégé

The invention relates to novel fluorescent dyes with phosphorylated hydroxymethyl groups, a method for preparing the same as well as to their use in imaging techniques. The fluorescent dyes are coumarin, rhodamine or BODIPY dyes having of one of the following general formulae I-III: c; and any salt thereof.

Classes IPC  ?

• C09B 57/02 - Colorants coumariniques
• G01N 33/52 - Utilisation de composés ou de compositions pour des recherches colorimétriques, spectrophotométriques ou fluorométriques, p. ex. utilisation de bandes de papier indicateur
• C09B 11/24 - Phtaléines contenant des groupes amine
• C09B 57/10 - Complexes métalliques de composés organiques qui ne sont pas des colorants sous la forme non complexée
• G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
• G01N 33/533 - Production de composés immunochimiques marqués avec un marqueur fluorescent

Abrégé

Tube-like device (100) for transferring ions generated by means of ion generation source (4) comprising a cylindrical middle portion (104) and an inlet portion (102) for introduction of the ions in at least one ion cloud into the cylindrical middle portion (104), wherein a flow direction of the ions is along a longitudinal axis (L) of the tube-like device (100), wherein the inlet portion (102) is formed tapering funnel-like towards the cylindrical middle portion (104).

Classes IPC  ?

• H01J 49/04 - Dispositions pour introduire ou extraire les échantillons devant être analysés, p. ex. fermetures étanches au videDispositions pour le réglage externe des composants électronoptiques ou ionoptiques

Abrégé

Methods are provided for producing an intermittent liquid jet are provided that involve delivering a liquid through a gas dynamic nozzle, which includes an inner tube carrying the liquid, an outer tube carrying a focussing sheath gas, an exit channel and an exit aperture, injecting a stream of the liquid into the exit channel, wherein the liquid is enclosed by the focussing sheath gas in the exit channel, controlling emission of the liquid from the inner tube into the exit channel to produce a periodic, linear intermittent liquid jet including spurts of linear continuous jet sections separated by liquid-free gaps, and output of the intermittent liquid jet through the exit aperture. Furthermore, methods of scattering measurements on samples in a liquid using the method of producing an intermittent liquid jet and an injector device for producing an intermittent liquid jet are described.

Classes IPC  ?

• B05B 1/02 - Buses, têtes de pulvérisation ou autres dispositifs de sortie, avec ou sans dispositifs auxiliaires tels que valves, moyens de chauffage agencés pour produire un jet, un pulvérisat ou tout autre écoulement de forme ou de nature particulière, p. ex. sous forme de gouttes individuelles
• B05B 1/08 - Buses, têtes de pulvérisation ou autres dispositifs de sortie, avec ou sans dispositifs auxiliaires tels que valves, moyens de chauffage agencés pour produire un jet, un pulvérisat ou tout autre écoulement de forme ou de nature particulière, p. ex. sous forme de gouttes individuelles de nature pulsatoire, p. ex. débitant un liquide en quantités successives séparées
• B05B 7/04 - Pistolets pulvérisateursAppareillages pour l'évacuation avec des dispositifs permettant le mélange de liquides ou d'autres matériaux fluides avant l'évacuation
• B05B 12/08 - Aménagements de commande de la distributionAménagements de réglage de l’aire de pulvérisation sensibles à l'état du liquide ou d'un autre matériau fluide expulsé, du milieu ambiant ou de la cible
• B05B 12/06 - Aménagements de commande de la distributionAménagements de réglage de l’aire de pulvérisation pour la commande de la durée ou de la succession des distributions pour réaliser un écoulement pulsatoire
• B05B 15/04 - Réglage de l'aire de pulvérisation, p.ex. à l'aide de masques, d'écrans latéraux; Moyens pour collecter ou réutiliser l'excès de matière (B05B 1/28 a priorité)

Abrégé

The invention refers to a method for diagnosing an individual who is to be subjected to or is being subjected to an anti-tumor necrosis factor alpha (TNFα or TNF) treatment to assess the responsiveness to an anti-TNF treatment which comprises the detection of immunoglobulin(s) against one or more biomarker proteins in a bodily fluid or an excrement of said patient, and sorting the individual into one of two categories based on detection of said immunoglobulin(s), wherein individuals are classified as NON-responder or responder. The invention refers to diagnostic kits comprising said one or more biomarker proteins and the use of these kits for assessing the responsiveness to an anti-TNF treatment of an individual who is to be subjected to or is being subjected to an anti-TNFα treatment.

Classes IPC  ?

• G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
• G01N 33/573 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour enzymes ou isoenzymes
• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
• G01N 33/564 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour complexes immunologiques préexistants ou maladies auto-immunes

Abrégé

The invention concerns a detector arrangement for detection of radiation, in particular particle radiation or electromagnetic radiation, with a semi-conductor detector with several pixels for detection of the radiation. It is proposed that the individual pixels each have a first subpixel (1) and a second subpixel (2). The semi-conductor detector can be switched between a first collection state, in which the first subpixel (1) is sensitive and the second subpixel (2) is insensitive so that radiation-generated signal charge carriers are substantially collected only in the first subpixel (1), and a second collection state in which the second subpixel (2) is sensitive and the first subpixel (1) is insensitive so that the radiation-generated signal charge carriers are collected substantially only in the second subpixel (2). The invention furthermore concerns a corresponding operating method and detector arrangements based on the same concept with a higher number of subpixels per pixel.

Classes IPC  ?

• H01L 27/146 - Structures de capteurs d'images
• H04N 5/341 - Extraction de données de pixels provenant d'un capteur d'images en agissant sur les circuits de balayage, p.ex. en modifiant le nombre de pixels ayant été échantillonnés ou à échantillonner

Abrégé

For spatial high resolution imaging of a structure of a sample, the structure comprising a luminophore, the sample, in a measurement area, is subjected to an intensity distribution of luminescence inhibiting light comprising a local minimum. Then, the sample, in the measurement area, is subjected to luminescence excitation light which excites the luminophore out of an electronic ground state into a luminescent state, and luminescence light emitted out of the measurement area is registered. This registered luminescence light is assigned to the position of the local minimum within the sample. The luminescence inhibiting light disturbs the electronic ground state of the luminophore such that the luminophore, in the disturbed electronic ground state, has an absorption cross-section for the luminescence excitation light which is reduced by at least 50% as compared to the undisturbed electronic ground state.

Classes IPC  ?

• G01T 1/00 - Mesure des rayons X, des rayons gamma, des radiations corpusculaires ou des radiations cosmiques
• G01N 21/64 - FluorescencePhosphorescence
• G01N 21/17 - Systèmes dans lesquels la lumière incidente est modifiée suivant les propriétés du matériau examiné
• G01N 21/65 - Diffusion de Raman

Abrégé

The present invention refers to a method for binding a polycarboxylic acid to a solid phase. Further, the invention refers to a solid phase having a polycarboxylic acid immobilized thereto and methods of using the solid phase, e.g. for purifying His-tagged recombinant polypeptides.

Classes IPC  ?

• C07K 1/22 - Chromatographie d'affinité ou techniques analogues basées sur des procédés d'absorption sélective
• B01J 20/32 - Imprégnation ou revêtement
• B01D 15/38 - Adsorption sélective, p. ex. chromatographie caractérisée par le mécanisme de séparation impliquant une interaction spécifique non couverte par un ou plusieurs des groupes , p. ex. chromatographie d'affinité, chromatographie d'échange par ligand ou chromatographie chirale
• B01J 45/00 - Échange d'ions dans lequel se forme un complexe ou un chélateUtilisation d'une substance comme échangeur d'ions formant des complexes ou des chélatesTraitement d'une substance en vue d'améliorer ses propriétés d'échange d'ions formant des complexes ou des chélates
• C07K 1/13 - Marquage de peptides
• B01J 20/286 - Phases reliées chimiquement à un substrat, p. ex. à de la silice ou à des polymères

Abrégé

An electrode material for a lithium-ion battery comprises a porous agglomeration of particles, the particles being formed from nanopowder of a transition metal oxide and comprising cores of stoichiometric transition metal oxide surrounded by under stoichiometric oxide of the transition metal. Also described and claimed are the use of a corresponding material in a lithium ion battery and a method of making such an electrode.

Classes IPC  ?

• H01M 4/36 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs
• H01M 4/485 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs d'oxydes ou d'hydroxydes inorganiques d'oxydes ou d'hydroxydes mixtes pour insérer ou intercaler des métaux légers, p. ex. LiTi2O4 ou LiTi2OxFy
• H01M 4/131 - Électrodes à base d'oxydes ou d'hydroxydes mixtes, ou de mélanges d'oxydes ou d'hydroxydes, p. ex. LiCoOx
• H01M 4/505 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs d'oxydes ou d'hydroxydes inorganiques de manganèse d'oxydes ou d'hydroxydes mixtes contenant du manganèse pour insérer ou intercaler des métaux légers, p. ex. LiMn2O4 ou LiMn2OxFy
• H01M 4/525 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs d'oxydes ou d'hydroxydes inorganiques de nickel, de cobalt ou de fer d'oxydes ou d'hydroxydes mixtes contenant du fer, du cobalt ou du nickel pour insérer ou intercaler des métaux légers, p. ex. LiNiO2, LiCoO2 ou LiCoOxFy
• H01M 4/62 - Emploi de substances spécifiées inactives comme ingrédients pour les masses actives, p. ex. liants, charges
• H01M 4/66 - Emploi de matériaux spécifiés
• H01M 10/0525 - Batteries du type "rocking chair" ou "fauteuil à bascule", p. ex. batteries à insertion ou intercalation de lithium dans les deux électrodesBatteries à l'ion lithium

Abrégé

A laser pulse amplifier device (100) includes an amplifying cavity (10) comprising an amplifying laser gain medium (11) and multiple cavity mirrors (12.1 to 12.7) spanning a cavity light path (13), wherein the amplifying cavity (10) is configured for an amplification of laser pulses (1) circulating along the cavity light path, and a multi-pass amplifier (20) being optically coupled with the amplifying cavity (10) and comprising multiple deflection mirrors (22) spanning a multipass light path (23), wherein the multi-pass amplifier (20) is configured for a post-amplification of laser pulses (2) coupled out of the amplifying cavity (10), wherein the amplifying cavity (10) and the multi-pass amplifier (20) are arranged such that the laser gain medium (11) of the amplifying cavity (10) is included as an active medium in the multi-pass light path (23) of the multi-pass amplifier (20). Furthermore, a method of amplifying laser pulses is described.

Classes IPC  ?

• H01S 3/06 - Structure ou forme du milieu actif
• H01S 3/08 - Structure ou forme des résonateurs optiques ou de leurs composants
• H01S 3/02 - Détails de structure
• H01S 3/23 - Agencement de plusieurs lasers non prévu dans les groupes , p. ex. agencement en série de deux milieux actifs séparés
• H01S 3/07 - Structure ou forme du milieu actif consistant en une pluralité de parties, p. ex. segments
• H01S 3/105 - Commande de l'intensité, de la fréquence, de la phase, de la polarisation ou de la direction du rayonnement, p. ex. commutation, ouverture de porte, modulation ou démodulation par commande de la position relative ou des propriétés réfléchissantes des réflecteurs de la cavité
• H01S 3/13 - Stabilisation de paramètres de sortie de laser, p. ex. fréquence ou amplitude
• H01S 3/00 - Lasers, c.-à-d. dispositifs utilisant l'émission stimulée de rayonnement électromagnétique dans la gamme de l’infrarouge, du visible ou de l’ultraviolet

Abrégé

The present invention relates to a method of generating an induced pluripotent stem (iPS) cell comprising the step of introducing into a target cell one or two coding sequences each giving rise upon transcription to a factor that contributes to the reprogramming of said target cell into an induced pluripotent stem cell and selected from Oct3/4 or a factor belonging to the Myc, Klf and Sox families of factors, wherein the target cell endogenously expresses at least the factors that are not encoded by the coding sequences to be introduced and selected from Oct3/4 or factors belonging to the Myc, Klf and Sox families of factors, and wherein the cell resulting from the introduction of the one or two coding sequences expresses the combination of factor Oct3/4 and at least one factor of each family of factors selected from the group of Myc, Klf and Sox. Furthermore, the present invention relates to an induced pluripotent stem cell generated by the method of the invention and a method of identifying a compound that contributes to the reprogramming of a target cell into an induced pluripotent stem cell. Also, a method of generating a transgenic non-human animal and a composition comprising an iPS cell generated by the method of the present invention for gene therapy, regenerative medicine, cell therapy or drug screening are envisaged.

Classes IPC  ?

• C12N 15/00 - Techniques de mutation ou génie génétiqueADN ou ARN concernant le génie génétique, vecteurs, p. ex. plasmides, ou leur isolement, leur préparation ou leur purificationUtilisation d'hôtes pour ceux-ci
• C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales
• C12N 5/074 - Cellules souches adultes
• C12N 15/873 - Techniques de production de nouveaux embryons, p. ex. transfert nucléaire, manipulation de cellules totipotentes ou production d'embryons chimériques
• A61D 19/04 - Instruments ou procédés pour la reproduction ou la fertilisation pour la transplantation d'embryons