A stick pack pouch package comprising a foil sheet having side edges and first and second edges extending transversely between the side edges, a fin having a longitudinal sealing joint extending between the side edges to form the foil sheet into a tube, wherein the tube has a front side and a back side, and wherein the fin is on the back side, first and second transverse sealing joints sealing the first and second edges, respectively, a weakened pattern which extends over/across at least a portion of the fin, the back side of the tube, and the front side of the tube, wherein the weakened pattern enables the package to be opened along the pattern and wherein the weakened pattern includes nonlinear portions on the front side, back side, or front and back sides of the tube.
B65D 75/58 - Dispositifs d'ouverture ou servant à retirer le contenu, ajoutés ou incorporés lors de la confection du paquet
2.
TOPICAL GEL COMPOSITIONS INCLUDING POLY(MONOSTEAROYL GLYCEROL-CO-SUCCINATE) POLYMER AND METHODS FOR ENHANCING THE TOPICAL APPLICATION OF A BENEFIT AGENT
A composition comprising: a benefit agent; at least one polymer including a poly(monostearoyl glycerol-co-succinate) polymer; at least one lower alcohol; and at least one co-solvent; and a method for enhancing topical delivery of a benefit agent are disclosed.
The present invention relates to oral compositions, comprising select phospholipid Surfactants. Methods for using the compositions are also disclosed. The present invention relates to aqueous compositions suitable for use in oral hygiene, especially for cleaning the mouth and the teeth. In particular, the present invention is concerned with improved oral care compositions suitable for use as mouth washes, mouth rinses, dentifrices, toothpastes, gels, solutions or strips such as peroxide or non-peroxide tooth whitening strips and the like.
A61K 8/55 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant du phosphore
4.
LOW MELTING PROPIONIC ACID DERIVATIVE PARTICLES FOR USE IN ORAL DOSAGE FORMS
Low melting propionic acid derivative particles that are free flowing and have significantly reduced or eliminated throat burn are disclosed. A method of manufacturing the low melting propionic acid derivative particles; dosage forms containing the low melting propionic acid derivative particles; methods of manufacturing the dosage forms; and methods of treatment using the dosage forms are also disclosed.
Low melting propionic acid derivative particles that are free flowing and have significantly reduced or eliminated throat burn are disclosed. A method of manufacturing the low melting propionic acid derivative particles; dosage forms containing the low melting propionic acid derivative particles; methods of manufacturing the dosage forms; and methods of treatment using the dosage forms are also disclosed.
Low melting propionic acid derivative particles that are free flowing and have significantly reduced or eliminated throat burn are disclosed. A method of manufacturing the low melting propionic acid derivative particles; dosage forms containing the low melting propionic acid derivative particles; methods of manufacturing the dosage forms; and methods of treatment using the dosage forms are also disclosed.
The present invention features a tablet containing at least one first material, at least one second material, and at least one pharmaceutically active agent, wherein: (a) the first material is a dielectric water-containing material (i) containing from about 1 to about 5 percent, by weight, of bound water and (ii) having a dielectric loss, when measured at a density of between 0.15 and 0.5 g/cc, of from about 0.05 to about 0.7; (b) the second material (i) having a water solubility from about 20 to about 400 g per 100g of water at 25°C, (ii) having a dielectric loss, when measured at a density between 0.5 and 1 g/cc, of less than about 0.05; (c) the tablet contains at least 15%, by weight, of the first material; (d) the combined weight of the at least one first material and the at least one second material is at least 60%, by weight, of the tablet; (e) the ratio of the at least one first material to the at least one second material is from about 20:80 to about 70:30; (f) the tablet has a density less than about 0.8 g/cc; and (g) the tablet disintegrates in the mouth when placed on the tongue in less than about 30 seconds.
In one aspect, the present invention features a machine for the production of a solid dosage form, the machine including: (a) a die block having one or more forming cavities each having an inner wall, a first opening at the surface of one side of the die block, and a second opening at the surface on the opposite side of the die block; (b) one or more first dosing nozzle adapted to both measure an amount of a first powder blend and discharge the measured amount of the first powder blend within one of the one or more forming cavity; (d) one or more first forming tools each adapted to move into one of the cavities through the first opening of the forming cavity; (e) one or more second forming tools each adapted to move adjacent to one of the second openings or into one of the cavities through the second opening of the forming cavity; (f) at least one first RF electrode operably associated with the one or more first forming tools, the one or more second forming tools, or the inner wall of the one or more forming cavities; and (g) at least one second RF electrode operably associated with the one or more first forming tools, the one or more second forming tools, or the inner wall of the one or more forming cavities; wherein the machine is adapted to form a dosage form between a first forming tool and a second forming tool within a forming cavity and wherein the first RF electrode and the second RF electrode are arranged within the machine such that when RF energy is applied between the first RF electrode and the second RF electrode, the RF energy passes through the portion of the forming cavity adapted to form the dosage form.
B30B 11/02 - Presses spécialement adaptées à la fabrication d'objets à partir d'un matériau en grains ou à l'état plastique, p. ex. presses à briquettes ou presses à tablettes utilisant un pilon exerçant une pression sur le matériau dans une cavité de moulage
In one aspect, the present invention features a tablet including a first region and a second region, wherein: (i) the first region and the second region each include at least 10%, by volume, of the tablet; (ii) the first region includes a pharmaceutically active agent and the composition of the first region is different from the composition of the second region; (iii) the first region has a density less than about 0.8 g/cc; and (iv) the first region disintegrates in the mouth when placed on the tongue in less than about 30 seconds; wherein the shape of the tablet includes two opposing major faces separated by a side wall, and the interface between the first region and the second region is along at least one major face of the tablet.
In one aspect, the present invention features a method of manufacturing a solid dosage form, the method including the steps of: (a) measuring an amount of a first powder blend within a dosing nozzle, wherein the first powder blend includes a pharmaceutically active agent; (b) discharging the measured amount of a first powder blend from the dosing nozzle into a forming cavity within a die block, the forming cavity having an inner wall, a first opening at the surface of one side of the die block, and a second opening at the surface on the opposite side of the die block; (c) moving a first forming tool into the forming cavity through the first opening of the forming cavity such that the first powder blend is formed into the shape of the dosage form within the forming cavity between the inner wall, the first forming tool and a second forming tool within or adjacent to the cavity; (d) applying RF energy between a first electrode and a second electrode such that the energy heats the first powder blend within the forming cavity to form the dosage form; and (e) removing the dosage form from the forming cavity.
B30B 11/02 - Presses spécialement adaptées à la fabrication d'objets à partir d'un matériau en grains ou à l'état plastique, p. ex. presses à briquettes ou presses à tablettes utilisant un pilon exerçant une pression sur le matériau dans une cavité de moulage
A device for directing a fluid onto a plurality of surfaces of the oral cavity, the device including a chamber for maintaining the fluid proximate the surfaces, where the chamber is defined by front, rear and base inner walls of the device and the front and rear inner walls each include a plurality of openings, the devices further including a first manifold a second manifold, a third manifold, and a fourth manifold, a first port, a second port, a third port, and a fourth port; and means for providing an effective seal of the device within the oral cavity.
Coated dosage forms comprising a tablet core, preferably in compressed form, that has a coating over its exterior surface and one or more patterns debossed in the tablet surface are disclosed. Methods for manufacturing such dosage forms are also disclosed.
A device for directing a liquid onto a plurality of surfaces of the oral cavity, the device including a handle, a neck, and a head, where the head includes a cleaning component including a chamber for maintaining the liquid proximate the surfaces, where the chamber is defined by front and rear sealing membranes, inner side walls and a base inner wall, and where the inner side walls each include a plurality of openings, the device further including a first manifold and a second manifold, a first port and a second port for conveying liquid; and means for providing an effective seal of the device within the oral cavity.
A device for directing a liquid onto a plurality of surfaces of the oral cavity, the device including a handle, a neck, and a head, where the head includes a cleaning component including a chamber for maintaining the liquid proximate the surfaces, where the chamber is defined by front and rear sealing membranes, inner side walls and a base inner wall, and where the inner side walls each include a plurality of openings, the device further including a first manifold and a second manifold, a first port and a second port for conveying liquid; and means for providing an effective seal of the device within the oral cavity.
A nasal composition for trapping allergens and allergen particles comprising a nasal spray/gel composition comprising microcrystalline cellulose and sodium carboxymethylcellulose and its salt derivatives thereof, wherein the microcrystalline cellulose to sodium carboxymethylcellulose are present in a ratio of about 50:50 to about 99:1, respectively, and wherein the nasal composition is substantially free of active pharmaceutical ingredients.
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 47/32 - Composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. carbomères
A method of blocking or trapping allergens or allergen particles in the nasal cavity of a subject, comprising the steps of applying to the nasal cavity of the subject a nasal composition comprising microcrystalline cellulose; and sodium carboxymethylcellulose and its salt derivatives thereof, wherein the microcrystalline cellulose to sodium carboxymethylcellulose are present in a ratio of about 50:50 to about 99: 1, respectively, and wherein the nasal composition is substantially free of active pharmaceutical ingredients.
A toothbrush with a replaceable head formed to permit ready removal and attachment without the use of a tool. The replaceable toothbrush head is advantageously formed for coupling with a power toothbrush, particularly, a power toothbrush with a power element that protrudes from the toothbrush head. The replaceable toothbrush head is thus formed to accommodate the power element. The replaceable toothbrush head is moved axially along an rotation axis for alignment with an alignment axis. The replaceable toothbrush head is then rotated about the rotation axis into a snap in engagement with the head of the toothbrush main unit.
A method of making an injection molded device includes the steps of (a) assembling a mold comprising a primary male mold half and a primary female mold half to define a primary mold cavity; (b) injecting a first fluid polymeric material into the primary mold cavity and permitting the first fluid polymeric material to solidify to form a device frame; (c) replacing the primary female mold half with a secondary female mold half; (d) restraining the device frame in the resulting mold cavity and injecting a second fluid polymeric material to form a first portion of an outer layer that retains the shape of the first overmold cavity; (e) replacing the primary male mold half with a secondary male mold half; and (f) injecting an additional amount of the second fluid polymeric material into the resulting cavity to form a sufficiently integral outer layer about the device frame.
B29C 45/16 - Fabrication d'objets multicouches ou polychromes
A61F 2/00 - Filtres implantables dans les vaisseaux sanguinsProthèses, c.-à-d. éléments de substitution ou de remplacement pour des parties du corpsAppareils pour les assujettir au corpsDispositifs maintenant le passage ou évitant l'affaissement de structures corporelles tubulaires, p. ex. stents
A61F 2/86 - Stents ayant une forme caractérisée par des éléments filiformesStents ayant une forme caractérisée par une structure de type filet ou de type à mailles
21.
ARTICLE INCLUDING VISUAL SIGNAL FOR COMMUNICATION OF DEPTH PERCEPTION
The present invention generally relates to an absorbent article including a plurality of non-colored portions and a plurality of colored portions having a single color, the plurality of non-colored portions and colored portions cooperating to create a perception of depth by a user viewing a top surface of the absorbent article.
A61F 13/15 - Garnitures absorbantes, p. ex. serviettes ou tampons hygiéniques pour application externe ou interne au corpsMoyens pour les maintenir en place ou les fixerApplicateurs de tampons
22.
ARTICLE INCLUDING VISUAL SIGNAL FOR COMMUNICATION OF A FUNCTIONAL BENEFIT
The present invention provides an absorbent article including a longitudinally extending a top surface, a cover layer, a barrier layer, an absorbent core arranged between the cover layer and the barrier layer, a printed portion, a plurality of non-printed portions, wherein the printed portion and the plurality of non-printed portions are arranged to create a perception of a functional benefit by a user looking upon the top surface of the absorbent article.
A liquid antitussive composition comprising about 0.05 grams to about 0.2 grams of menthol per 100 ml of liquid antitussive composition, a solvent system, and a surfactant, wherein the composition has a maximum alcohol content of about 0.5 grams per 100 ml of the liquid antitussive composition, and wherein the composition is stable for about 6 months at 40 °C, 75% relative humidity conditions.
The present invention generally relates to absorbent sanitary articles for absorption of body fluids and in particular to a sanitary article of this type including a buffer composition adapted to adjust the natural pH of the absorbed body fluid to a pH that is compatible with the pH of skin.
A recloseable closure for a container such as secondary packaging. The recloseable closure has a tuck tab (112) to be tucked into a tuck slit (120) to maintain the closure in a closed configuration to maintain articles within the secondary packaging. The tuck tab has a unique configuration, and the tuck slit has a protrusion ((122) that also has a unique configuration and which is positioned to cover the tuck tab when the tuck tab is tucked in the tuck slit. The tuck tab may be shaped to conform to the shape of the contents of the container, and / or may have a graphic element printed thereon, illustrating the contents of the container. The tuck slit protrusion may be configured to conform to the shape of the tuck tab and to bear the same graphic element as on the tuck tab. Thus, when the tuck tab is tucked into the slit, the tuck slit protrusion covers the tuck tab while still displaying substantially the same graphic element displayed by the tuck flap.
B65D 5/20 - Réceptacles de section transversale polygonale rigides ou semi-rigides, p. ex. boîtes, cartons ou plateaux, formés en pliant ou montant un ou plusieurs flans de papier en repliant les parties reliées à un panneau central sur chaque côté pour former le corps du réceptacle, p. ex. en forme de plateau
B65D 5/42 - Détails des réceptacles ou des flans de réceptacles pliables ou dressables
A system and device for providing a beneficial effect to the oral cavity of a mammal, the system including means for directing a fluid effective to provide the beneficial effect onto a plurality of surfaces of the oral cavity; and the hand-held device, the hand-held device being suitable for providing the fluid to the directing means, and including means for providing reciprocation of the fluid, means for controlling the reciprocation of the fluids, means for conveying the fluid through the device system, a reservoir for containing the fluid, a power source and a linear motor.
An intravaginal device has a first structural material formed into a device frame and a second cushioning material having a thickness surrounding portions of the device frame. The first structural material includes a working portion and an anchoring portion extending therefrom. The device frame includes interconnected elongate elements having a maximum cross-section of less than about 5 mm and a longitudinal axis. The device frame has a plurality of primary bearing surfaces arranged and configured to bear on vaginal tissue during insertion and use, and the thickness of the cushioning material on the device frame is greater on the primary bearing surfaces than on surfaces of the device frame disposed toward the device interior. Preferably, the first structural material is a high modulus polymer and the second material is a thermoplastic elastomer. The intravaginal device may be included in a device delivery system including a delivery applicator.
A61F 2/00 - Filtres implantables dans les vaisseaux sanguinsProthèses, c.-à-d. éléments de substitution ou de remplacement pour des parties du corpsAppareils pour les assujettir au corpsDispositifs maintenant le passage ou évitant l'affaissement de structures corporelles tubulaires, p. ex. stents
30.
MULTI-LAYERED ORALLY DISINTEGRATING TABLET AND THE MANUFACTURE THEREOF
The present invention features a tablet containing a first layer and a second layer, wherein: (i) the first layer includes a pharmaceutically active agent and the composition of the first layer is different from the composition of the second layer; (ii) the tablet has a density less than about 0.8 g/cc; and (iii) the tablet disintegrates in the mouth when placed on the tongue in less than about 30 seconds.
The present invention features the present invention features a tablet including at least one pharmaceutically active ingredient, wherein the shape of said tablet includes at least one major face wherein: (i) the peak penetration resistance at the perimeter of said major face of the tablet is at least about 10% greater than the peak penetration resistance at the center of said major face; and (ii) the tablet disintegrates in the mouth when placed on the tongue in less than about 30 seconds, and a machine and method for manufacture of such tablet.
B30B 11/02 - Presses spécialement adaptées à la fabrication d'objets à partir d'un matériau en grains ou à l'état plastique, p. ex. presses à briquettes ou presses à tablettes utilisant un pilon exerçant une pression sur le matériau dans une cavité de moulage
B30B 15/34 - Chauffage ou refroidissement des presses ou des parties de presse
B30B 11/10 - Presses spécialement adaptées à la fabrication d'objets à partir d'un matériau en grains ou à l'état plastique, p. ex. presses à briquettes ou presses à tablettes utilisant un pilon exerçant une pression sur le matériau dans une cavité de moulage coopérant avec des moules portés par une table tournante à mouvement intermittent
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
32.
MANUFACTURE OF TABLETS FROM ENERGY-APPLIED POWDER BLEND
The present invention features a process for making tablets containing one or more pharmaceutically active agent(s) and one or more binder(s), the method including the steps of (i) applying energy to a powder blend comprising the pharmaceutically active agent(s) and the binder(s)for a sufficient period of time to activate the binder(s) within the powder blend and (ii) forming a predetermined amount of the energy-applied powder blend into the tablets.
A capsule-like dosage form, method for producing such dosage form and apparatus are disclosed. Such dosage form is achieved by applying a sleeve over the caplet to provide a coating which is smoother and easier to swallow than an uncoated caplet. The production of the capsule-like dosage form is readily facilitated by simple and inexpensive modifications to existing empty gelatin capsule making equipment.
Devices for collecting a fluid sample from the oral cavity, the device including a mouthpiece that includes a chamber, the chamber including front and rear inner walls; and means for collecting the fluid sample from the oral cavity; and methods of collecting and analyzing samples of fluid from the oral cavity, including the steps of placing the device in the oral cavity, collecting the fluid sample and conducting an analysis of the fluid sample.
A61C 17/00 - Dispositifs pour nettoyer, polir, rincer ou sécher les dents, les cavités dentaires ou les prothèsesAppareils pour enlever la saliveRéceptacles pour les crachats à usage dentaire
Hydrated celecoxib sodium salt forms and processes to prepare hydrated celecoxib sodium salt forms are disclosed. The celecoxib sodium salt forms are particularly useful and suitable for pharmaceutical applications.
C07D 231/24 - Un atome d'oxygène lié en position 3 ou 5 avec des radicaux aryle liés aux atomes d'azote du cycle comportant des radicaux sulfone ou acide sulfonique dans la molécule
A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
A method for cleaning an oral cavity by positioning a device suitable for detecting and removing plaque from a surface within the oral cavity having applied thereto a fluorescent agent capable of binding to plaque on the surface, substantially simultaneously cleaning and irradiating the surface with a light of a wavelength effective to provide a fluorescent emission when contacted with the fluorescent agent, collecting at least a portion of the fluorescent emission over a predetermined first time period (PTP1), determining an average plaque value (APV) based on the fluorescent emission collected over the PTP1, comparing the APV to a predetermined plaque value (PPV), and continuing to substantially simultaneously clean and irradiate the surface within the oral cavity for a predetermined second time period (PTP2).
Devices and methods for cleaning an oral cavity by positioning a device suitable for detecting and removing plaque from the surface within the oral cavity having applied thereto a fluorescent agent capable of binding to plaque on the surface. The surface is substantially simultaneously cleaned and irradiated with a light of a wavelength effective to provide a fluorescent emission when contacted with said fluorescent agent. A portion of the fluorescent emission is collected (APV1), and compared to a predetermined threshold value (PPTV). If APV1 is less than PPTV, the device is moved to another section. If APVl is greater than or equal to PPTV, then another portion of fluorescent emission is collected (APV2). The percent reduction from APV1 to APV2 determines when the device is moved to another section.
A method of cleaning an oral cavity, the method including positioning a device suitable for detecting and removing plaque from a surface of the oral cavity within the oral cavity, cleaning and irradiating the surface of a tooth in the oral cavity, the tooth having applied thereto a fluorescent agent, with incident radiation of a wavelength effective to provide a fluorescent emission when contacted with the fluorescent agent on the tooth, collecting at least a portion of the fluorescent emission over a first time period, determining a first average fluorescent emission value (APV1), collecting at least a portion of the fluorescent emission over a second time period, determining a second average plaque value (APV2); and comparing the APV1 to the APV2.
A bristle configuration (114) providing enhanced cleaning of teeth. At least one elongated bristle tuft (120) is formed to at least partially enclose an area, and a complementary- shaped tuft (122) is provided in the at least partially enclosed area. The elongated tuft (120) and the complementary tuft (122) have angled profiles angled to a different degree, and preferably also in a different direction. A series of elongated tufts (120) with angled profiles may be provided to form an overall bristle profile providing enhanced cleaning of teeth. In addition, one or more tufts (134, 134') may be provided along the elongated tufts (120) to form another tuft pattern along the pattern formed by the elongated tufts (120). In one embodiment, the other tuft pattern presents a contoured bristle profile angled to a different degree from the profile of the elongated tufts (120) along which the other tuft pattern is provided.
A46B 9/04 - Position ou disposition des soies par rapport à la surface de la monture, p. ex. inclinées, en rangées, en groupes pour les brosses à dents
42.
METHOD AND APPARATUS FOR IN VITRO TESTING FOR MEDICAL DEVICES
Apparatus for simulating a female vagina includes a pressure chamber, a vaginal model disposed in a pressure chamber and means to deliver liquid into the vaginal model. The pressure chamber includes an interior, first means to provide fluid pressure to the pressure chamber, and second means to provide localized fluid pressure within the pressure chamber. The vaginal model includes a wall that (1 ) defines a vaginal lumen extending inwardly from a vaginal opening associated with a bore through an exterior surface of the pressure chamber to vaginal fornices adjacent a cervical port; (2) has an outer surface comprising an anterior vaginal surface and a posterior vaginal surface; and (3) has at least one passage for providing a fluid to the cervical port. Methods for using this apparatus are also disclosed.
The present invention generally relates to sanitary absorbent articles and in particular to disposable feminine sanitary absorbent articles that are extremely thin, highly absorbent and have superior structural integrity properties.
A61F 13/15 - Garnitures absorbantes, p. ex. serviettes ou tampons hygiéniques pour application externe ou interne au corpsMoyens pour les maintenir en place ou les fixerApplicateurs de tampons
44.
ULTRA THIN LAMINATE WITH PARTICULATES IN DENSE PACKAGES
The present invention is directed to a method of forming a laminate absorbent structure, and a resulting package containing a single continuous running web of the laminate material. Notably, formation of the material is effected by blending a curtain of adhesive fibers with a curtain of particulate material, and depositing the mixture on a moving substrate, preferably provided in the form of a tissue layer. A second substrate, also preferably comprising a tissue layer, is applied on top of the deposited mixture, and pressure applied to form the laminated structure. Notably, attendant to packaging of the laminated material, adjacent layers of the material tend to nest into one another, to form a sandwich in which the density of the material in the package is more than 1.5 times the density of the material after its removal from the package.
A61F 13/15 - Garnitures absorbantes, p. ex. serviettes ou tampons hygiéniques pour application externe ou interne au corpsMoyens pour les maintenir en place ou les fixerApplicateurs de tampons
The present disclosure relates to compositions containing certain pyrimidine compounds such as minoxidil and/or certain pyrimidine sulfate (inner salt) compounds such as minoxidil sulfate and especially compositions containing pyrimidine compounds in combination with an admixtures comprising at least one antioxidant, at least one organic acid and a select fatty acid mixture. The present disclosure also relates to use of the compositions to grow and/or regrow hair and/or prevent hair loss in mammals and particularly in humans.
A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
A61K 8/36 - Acides carboxyliquesLeurs sels ou anhydrides
The present disclosure relates to methods of retarding hair loss or facilitating hair growth and/or regrowth. More specifically, the present disclosure relates to methods of using the disclosed compositions to increase the rate of terminal hair growth and/or regrowth in a mammal.
A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
An intravaginal urinary incontinence device has an insertion end and an opposed withdrawal end. The device has a resilient frame including a working portion disposed proximate the withdrawal end and an anchoring portion disposed proximate the insertion end. The working portion has a resilient structure having a plurality of connected elongate elements for providing support to an associated urinary system. The anchoring portion has a plurality of connected elongate elements arranged to expand laterally within a user's vagina. The elongate elements are formed of a high modulus polymer having an elastic modulus of at least 2 or 3 GPa. Additionally, the polymer may have an Initial Stress @ 3% Strain of at least about 30 MPa, an elongation at yield of at least 3%, a Stress Ratio of at least about 0.5, and/or an Aged Stress (t=50 hrs @ 40° C) @ 3% Strain is greater than about 35 MPa.
A dosage form comprising a tablet core containing at least one active ingredient and having at least one modified release coating that partially surrounds the tablet core is disclosed. The tablet core is preferably in the form of a compressed core wherein the at least one modified release coating is provided on a position of the exterior surface of the compressed core using dipping technology. The invention also relates to a method of manufacturing the dosage form and a method of treatment using the dosage form.
Decorated products, such as toothbrushes, of substantially the same type and having substantially the same features (preferably functional features) except for a decorative element. The decorative element on each product is selected from a plurality of different decorative elements such that the products may be visually or aesthetically differentiated from one another by the differences in the decorative element associated therewith, while otherwise having the same functional characteristics. An exemplary embodiment is sleeved adult toothbrushes, the sleeves each having one of a variety of designs, the set of available designs including designs of different categories to appeal to different consumer bases (e.g., different ages, genders, styles, etc.) or to signal a time period for use of the product (e.g., a variety of designs for each of the four seasons to signal changing the toothbrush each season). Preferably, the products are decorated with a design selected from more than one category of designs, at least two of which categories include more than one design. The designs may be changed for the product line on a regular or semi-regular basis to refresh the appearance of the products.
In certain embodiments, the present invention relates to compounds, compositions, and methods for disrupting biofilms. In some embodiments, the compounds and compositions comprise unsaturated long chain alcohols and/or aldehydes, or combinations of such compounds. In further embodiments, the present invention contains therapeutic actives to help reduce and/or eradicate the bacteria in the biofilm once the film is disrupted.
A pharmaceutical composition for oral administration comprising a core and a film coating on the core that exhibits enhanced disintegration characteristics is disclosed. The film coating comprises a film forming polymer, an organic solvent, a super-disintegrant and, optionally, an acid labile material.
The present invention features a tablet including one or more pharmaceutically active agent(s), one or more thickeners, and one or more binder(s), wherein the tablet includes at least 200 mg of the pharmaceutically active agent(s) and the tablet has been fused with the binder(s) such that the tablet (i) has a water permeation time of less than 60 seconds and (ii) has an in vitro disintegration time of greater than 60 seconds.
In one aspect, the present invention features a process for making a tablet including a pharmaceutically active agent wherein the tablet has both an immediate release region and a modified release region. The method includes the steps of: (a) forming a tablet shape including a powder blend containing a pharmaceutically active agent and a thermally-sensitive material; and (b) applying energy in different amounts to different regions of the tablet shape to form the tablet in a manner such that: (i) a first region of the tablet shape is exposed to said energy for a sufficient period of time to melt the thermally-sensitive material within the first region to form said modified release region of said tablet; and (ii) a second region of said tablet shape is not so exposed to the energy such that said second region forms the immediate release region of said tablet.
The present invention features a process for making a lozenge product including the steps of forming a powder blend containing an amorphous carbohydrate polymer into the desired shape of the lozenge product and applying radiofrequency energy to the shape for a sufficient period of time to soften or melt said amorphous carbohydrate polymer to fuse the shape into said lozenge product.
The present invention features a process for making a chewing gum product including the steps of forming a powder blend containing a gum base into the desired shape of the chewing gum product and applying radio frequency energy to the shape for a sufficient period of time to soften the gum base to fuse the shape into the chewing gum product.
The present invention features a process for making a tablet by (i) compacting a powder blend in a die to form a tablet shape, wherein the powder blend contains a pharmaceutically active agent and a meltable binder and (ii) applying radio frequency energy to the tablet shape for a sufficient period of time to soften or melt the binder within said tablet shape to form the tablet.
The present invention features the present invention features a process for making a tablet by compacting a powder blend in a die platen to form a tablet shape, wherein the powder blend includes a pharmaceutically active agent and a water-containing material, and applying energy to the tablet shape for a sufficient period of time to heat the water- containing material within the tablet shape above its dehydration temperature to form the tablet.
The present invention features the present invention features a machine for the production of a solid dosage form including: (a) a die platen having one or more forming cavities each having an inner wall, a first opening at the surface of one side of the die platen, and a second opening at the surface on the opposite side of the die platen; (b) one or more first forming tools each adapted to move into one of the forming cavities through the first opening of the forming cavity; (c) one or more second forming tools each adapted to move adjacent to one of the second openings or into one of the forming cavities through the second opening of the forming cavity; (d) at least one first RF electrode operably associated with the one or more first forming tools, the one or more second forming tools, or the inner wall of the one or more forming cavities; and (e) at least one second RF electrode operably associated with the one or more first forming tools.
B30B 11/02 - Presses spécialement adaptées à la fabrication d'objets à partir d'un matériau en grains ou à l'état plastique, p. ex. presses à briquettes ou presses à tablettes utilisant un pilon exerçant une pression sur le matériau dans une cavité de moulage
B30B 15/34 - Chauffage ou refroidissement des presses ou des parties de presse
B30B 11/10 - Presses spécialement adaptées à la fabrication d'objets à partir d'un matériau en grains ou à l'état plastique, p. ex. presses à briquettes ou presses à tablettes utilisant un pilon exerçant une pression sur le matériau dans une cavité de moulage coopérant avec des moules portés par une table tournante à mouvement intermittent
59.
PROCESS FOR THE MANUFACTURE OF NICOTINE-COMPRISING CHEWING GUM AND NICOTINE-COMPRISING CHEWING GUM MANUFACTURED ACCORDING TO SAID PROCESS
A process for making a nicotine-comprising chewing gum by (i) dispensing a powder portion from a gum-base-comprising powder, (ii) optionally shaping said powder portion into a powder aggregate, and (iii) applying sufficient electromagnetic energy (EM energy) to said powder portion or said powder aggregate to transform said powder portion or said powder aggregate into said chewing gum, whereby said EM energy is Radio Frequency (RF) energy, Micro Wave (MW) energy, InfraRed (IR) energy or Ultraviolet (UV) energy or combinations thereof. The invention also features a chewing gum made by such process. The chewing gum may comprise one or more deposits.
B30B 11/02 - Presses spécialement adaptées à la fabrication d'objets à partir d'un matériau en grains ou à l'état plastique, p. ex. presses à briquettes ou presses à tablettes utilisant un pilon exerçant une pression sur le matériau dans une cavité de moulage
B30B 15/34 - Chauffage ou refroidissement des presses ou des parties de presse
B30B 11/10 - Presses spécialement adaptées à la fabrication d'objets à partir d'un matériau en grains ou à l'état plastique, p. ex. presses à briquettes ou presses à tablettes utilisant un pilon exerçant une pression sur le matériau dans une cavité de moulage coopérant avec des moules portés par une table tournante à mouvement intermittent
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A device for directing a liquid onto a plurality of surfaces of the oral cavity, the device including a chamber for maintaining the liquid proximate the surfaces, where the chamber is defined by front, rear and base inner walls of the device and the front and rear inner walls each include a plurality of openings, the devices further including a first manifold and a second manifold, a first port and a second port; and means for providing an effective seal of the device within the oral cavity.
An oral care system that provides a beneficial effect to an oral cavity of a mammal by using a liquid effective for providing the beneficial effect, where the system includes means for directing the liquid onto a plurality of surfaces of the oral cavity, means for providing the liquid to the means for directing the liquid onto the surfaces of the oral cavity, means for providing reciprocation of the liquid over the plurality of surfaces under conditions effective to provide the beneficial effect; and a reservoir for containing the liquid.
A method for providing a beneficial effect to an oral cavity of a mammal, the method including contacting a plurality of surfaces of the oral cavity with a liquid effective for providing the beneficial effect to the oral cavity and providing reciprocation of the liquid over the plurality of surfaces of the oral cavity under conditions effective to provide the beneficial effect.
An oral care device suitable for use in providing a beneficial effect to an oral cavity of a mammal, which device includes means for providing reciprocation of a liquid effective for providing the beneficial effect of the oral cavity when the liquid is contacted with a plurality of surfaces thereof under conditions effective to provide the beneficial effect.
In one aspect, the present invention features a tablet including a compressed core and a liquid filled capsule, wherein the compressed core includes a first pharmaceutically active agent, the compressed core has a cavity exposed on the surface of the core, and the capsule is contained within the cavity such that a portion of the capsule is visible on the surface of the tablet, wherein the capsule has a diameter of at least 500 microns.
A61K 31/137 - Arylalkylamines, p. ex. amphétamine, épinéphrine, salbutamol, éphédrine
A61K 31/167 - Amides, p. ex. acides hydroxamiques ayant des cycles aromatiques, p. ex. colchicine, aténolol, progabide ayant l'atome d'azote d'un groupe carboxamide lié directement au cycle aromatique, p. ex. lidocaïne, paracétamol
65.
ELECTRICAL STIMULATION DEVICE WITH ADDITIONAL SENSORY MODALITIES
A therapeutic apparatus comprising an electrical stimulation delivery means, and at least one secondary modality delivery means, wherein the secondary modality delivery means is in an active state during at least a portion of a refractory period of the electrical stimulation delivery means.
A61N 1/34 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour provoquer l'anesthésie
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (USA)
Inventeur(s)
Chandra, Dinesh
Soshinsky, Andre, A.
Gambogi, Robert, J.
Yang, Shu
Abrégé
The present invention relates to a tooth- whitening composition comprising (i) a substantially water-insoluble and substantially non-degradable polymer matrix component capable of adhering to the surface of a tooth, provided that if the polymer matrix component is in non-solid form, it is solidifϊable by chemical alteration; and (ii) gas- or liquid- filled pores embedded in said polymer matrix component, wherein at least a portion of said gas- or liquid-filled pores have at least one size dimension in the range of about 70 nm to about 5 microns, and wherein the gas- or liquid-filled pores and polymer matrix component possess a difference in refractive index of at least 0.1. The invention is also directed to a tooth- whitening system containing the above composition in combination with an applicator device. The invention is also directed to methods for applying the tooth- whitening composition onto teeth.
In one aspect, the present invention features a tablet including a first drug layer and a second drug layer, wherein: (i) the first drug layer includes first drug particles including naproxen and third drug particles including cetirizine, where the first drug particles and/or the third drug particles are coated with an immediate release coating; and (ii) the second drug layer including pseudoephedrine, wherein said second drug layer is a sustained release layer adapted to deliver a therapeutically effective amount of pseudoephedrine for a period of at least twelve hours.
A61K 31/137 - Arylalkylamines, p. ex. amphétamine, épinéphrine, salbutamol, éphédrine
A61K 31/192 - Acides carboxyliques, p. ex. acide valproïque ayant des groupes aromatiques, p. ex. sulindac, acides 2-aryl-propioniques, acide éthacrynique
A61K 31/495 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec deux azote comme seuls hétéro-atomes d'un cycle, p. ex. pipérazine
In one aspect, the present invention features a tablet including: (i) a first drug layer including naproxen; (ii) a second drug layer including a decongestant (e.g., pseudoephedrine) wherein said second drug layer is a sustained release layer adapted to deliver a therapeutically effective amount of pseudoephedrine for a period of at least twelve hours; and (iii) a barrier layer that does not include naproxen, wherein the barrier layer is in contact with the first drug layer; and (iv) a third drug layer including cetirizine, wherein the third drug layer is in contact with the barrier layer and is not in contact with the first drug layer.
A61K 31/137 - Arylalkylamines, p. ex. amphétamine, épinéphrine, salbutamol, éphédrine
A61K 31/192 - Acides carboxyliques, p. ex. acide valproïque ayant des groupes aromatiques, p. ex. sulindac, acides 2-aryl-propioniques, acide éthacrynique
A61K 31/495 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec deux azote comme seuls hétéro-atomes d'un cycle, p. ex. pipérazine
In one aspect, the present invention features a tablet including a first drug layer, a second drug layer, and a third drug layer, wherein (i) the first drug layer includes naproxen; (ii) a second drug layer including pseudoephedrine; and (iii) the third drug layer includes cetirizine; wherein the first drug layer is in contact with the second drug layer, the third drug layer is in contact with the second drug layer, and the first drug layer is not in contact with the third drug layer, and wherein the second drug layer is a sustained release layer adapted to deliver a therapeutically effective amount of pseudoephedrine for a period of at least twelve hours.
A61K 31/137 - Arylalkylamines, p. ex. amphétamine, épinéphrine, salbutamol, éphédrine
A61K 31/192 - Acides carboxyliques, p. ex. acide valproïque ayant des groupes aromatiques, p. ex. sulindac, acides 2-aryl-propioniques, acide éthacrynique
A61K 31/495 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec deux azote comme seuls hétéro-atomes d'un cycle, p. ex. pipérazine
Tampons are packaged in a substantially cylindrical wrapper formed of a flexible, sheet-like material that is closed with one or more attachment zones having one or more gaps crossed by a line of weakness. The wrapper is closed at both ends and has a longitudinal seam area in which overlapping portions of the flexible, sheet-like material are attached. The longitudinal seam area comprises a substantially longitudinal attachment zone with a first edge and a second edge that defines a seam area. The line of weakness has a first end disposed within the seam area at a distance from a first end of the wrapper package; extends through a gap in the substantially longitudinal attachment zone; continues generally circumferentially about the wrapper; and terminates at a second end disposed within the seam area at the second edge of the substantially longitudinal attachment zone. The line of weakness extends across the seam area, and the wrapper can be removed as a single piece.
A packaged elongate intravaginal device has an overwrap substantially enclosing the device. The overwrap has a longitudinal overlap seam disposed generally parallel to the longitudinal axis. The seam includes one ply of overwrap material disposed at a first margin of a overwrap blank superposed on a second ply of overwrap material disposed at a second margin of the overwrap blank, opposite the first. The overwrap has a substantially continuous line of weakness that intersects a plane including the longitudinal axis of the packaged device at at least three unique locations. The line of weakness extends across the longitudinal overlap seam and includes weakness components superposed in each ply of the overlap seam, and the line of weakness is arranged and configured in a manner to permit the overwrap to remain as a unitary structure upon destruction of the line of weakness.
A process for manufacturing robust, flexible sheet-like material, includes the steps of a) applying a waxy composition to the web to form a waxed web; b) leading the waxed web via at least one roller to a chiller; c) cooling the waxed web; and d) leading the waxed web to a collection station for collecting the waxed web for further processing. The waxy composition comprises about 10-60 wt-% of a waxy compound and about 90-40 wt-% of a diluent. The waxy compound is selected from the group consisting of A) monoesters of a polyhydric aliphatic alcohol and a fatty acid; B) diesters of a polyhydric aliphatic alcohol and a fatty acid; and C) mixtures of said monoesters and diesters.
A composition of matter includes a flexible substrate and a coating disposed on the substrate. The coating comprises about 10-60 wt-% of a waxy compound and about 90-40 wt-% of a diluent. The coating forms a stable liquid mixture at a temperature between about 35° C and about 100° C, has a liquefaction temperature of at least about 30° C, and has a contact angle with a flat surface of the substrate of less than about 35° when measured at a temperature of 60° C.
The application of active ingredients, exemplified by GML, to absorbent fibers, such as rayon fibers, used in tampon manufacture at very low levels has been found to maintain efficacy in the inhibition of the production of toxic shock syndrome toxin one (TSST-1 ) produced by S. aureus without overtly killing the microorganism to achieve the desired reduction while avoiding undesired test results that suggest the presence of "impurities" in some jurisdictions.
The present invention features a method of manufacturing an osmotic tablet including the steps of (i) compressing a tablet core including a first pharmaceutically active agent and a hydrophilic polymer; (ii) applying an osmotic coating to the outer surface of the tablet core to form a coated tablet, wherein the osmotic coating includes at least one opening exposing the tablet core; and (iii) compressing an immediate release coating onto the surface of the coated tablet, wherein the release coating includes a second pharmaceutically active agent.
Apparatus for knotting at least one string of material has a fixed knotter plate, a primary knotter plate, a secondary knotter plate, means to apply tension to the string, and means for threading the string through the knotter plates.
A method and apparatus for displaying and selling related products in an aisle containing a single type of product. An interrupter is provided in a display are to interrupt the display of the single product in that display area and to draw the consumer's attention to a related product that may be used in conjunction with the single type of product displayed in that area. The interrupter may be in the form of a stand-alone display structure. Preferably, the different product to be displayed is framed by the interrupter. Indicia, such as information on how the products are to be used in conjunction with one another, may be provided on the interrupter.
In one aspect, the present invention features a method of producing a tablet including cetirizine including the steps of: (i) mixing cetirizine, a polyol, and a solvent for the cetirizine to form a cetirizine:polyol complex, wherein the solvent comprises water and an alkalizing agent and has a pH from about 2 to about 7; (ii) isolating particles of the cetirizine:polyol complex from the mixture; and (iii) forming the particles into a tablet.
A61K 31/495 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec deux azote comme seuls hétéro-atomes d'un cycle, p. ex. pipérazine
A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p. ex. rifampine, thiothixène ou sparfloxacine
A61K 47/48 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. supports, additifs inertes l'ingrédient non actif étant chimiquement lié à l'ingrédient actif, p.ex. conjugués polymère-médicament
79.
COMBINED PORTABLE THERMAL AND VIBRATORY TREATMENT DEVICE
The present invention is directed to a reusable pain relieving treatment device, such as a belt, and a disposable thermal insert comprising one or more thermally conductive component that extend from an inner surface of the device and are capable of transferring heat, cold and vibrations from disposable or reusable inserts.
A61H 23/02 - Massage par percussion ou vibration, p. ex. en utilisant une vibration ultrasoniqueMassage par succion-vibrationMassage avec des membranes mobiles à entraînement électrique ou magnétique
A61F 7/02 - Compresses ou cataplasmes procurant de la chaleur ou du froid
A method of making a granulation comprising the steps of (a) combining sucralose, a polar solvent, a wettable material and an active agent, thereby forming a mixture; and (b) drying the mixture, thereby forming the granulation.
The present invention features a tablet including particles containing a pharmaceutically active agent, wherein the particles are coated with (a) a first film layer containing a modified release polymer; and (b) a second film layer containing (i) a first polymer, wherein the first polymer is a polymer of ethyl acrylate and methyl methacrylate and (ii) a second polymer, wherein the second polymer is a polymer of methyl acrylate, methyl methacrylate and methacrylic acid.
The present invention is directed to a delivery device and method for the sequential delivery of a topical pain relieving composition and an occluding composition. These two compositions are held in a single device that comprises at least two chambers for manual and or pressurized delivery of these compositions to the patient's skin.
A61L 26/00 - Aspects chimiques des bandages liquides ou utilisation de matériaux pour les bandages liquides
A61M 11/00 - Pulvérisateurs ou vaporisateurs spécialement destinés à des usages médicaux
B05B 11/00 - Appareillages monoblocs tenus à la main dans lesquels l'écoulement du contenu est produit par la force musculaire de l'opérateur au moment de l'utilisation
B65D 81/32 - Réceptacles, éléments d'emballage ou paquets pour contenus présentant des problèmes particuliers de stockage ou de transport ou adaptés pour servir à d'autres fins que l'emballage après avoir été vidés de leur contenu pour emballer plusieurs matériaux différents qui doivent être maintenus séparés avant d’être mélangés
A61F 7/02 - Compresses ou cataplasmes procurant de la chaleur ou du froid
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
The present invention is directed to a reusable pain relieving treatment device, such as a belt, and a disposable thermal device having one or more thermally conductive components that extend from a surface of the device and are capable of transferring heat, cold or vibrations from disposable or reusable devices to targeted sections of the user's body.
The present invention features a method of making a coated tablet by dipping a core comprising an active agent into a coating liquid and drying said dipped core to form a outer-coating on the core, wherein the coating liquid contains at least one a starch having an amylose content of at least about 50 percent by weight of said starch.
The present invention is directed to an edible film that contains two or more segmented portions and comprises an active ingredient that is distributed on a segmented portion or portions which comprise less than 50% of the cross sectional surface area of a major face of said film. The present invention also relates to methods of treatment for the treatment of various conditions and for taste-masking of pharmaceutical ingredients.
A61K 47/48 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. supports, additifs inertes l'ingrédient non actif étant chimiquement lié à l'ingrédient actif, p.ex. conjugués polymère-médicament
86.
EDIBLE FILM-STRIPS WITH MODIFIED RELEASE ACTIVE INGREDIENTS
The present invention is directed to an edible film that contains a modified release active ingredient. The active ingredient may be present in the edible film a variety of forms, including a modified release matrix, in a modified release particulate form, in microgel liquid filled beads or in a bilayer film. The present invention also includes edible films which comprise additional immediate release active ingredients.
A61K 47/48 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. supports, additifs inertes l'ingrédient non actif étant chimiquement lié à l'ingrédient actif, p.ex. conjugués polymère-médicament
The present invention is directed to a reusable pain relieving treatment device, such as a belt, that comprises one or more conductive members that extend from an inner surface of the device and are capable of transferring heat, cold or vibrations from disposable or reusable packs.
A61H 15/02 - Massage au moyen de rouleaux, de boules, p. ex. gonflables ou de chaînes ou de chaînes de rouleaux conçus pour appliquer simultanément un traitement par la lumière, la chaleur ou des produits pharmaceutiques
A61F 7/02 - Compresses ou cataplasmes procurant de la chaleur ou du froid
A61F 7/00 - Appareils de chauffage ou de refroidissement pour traitement médical ou thérapeutique du corps humain
A61H 15/00 - Massage au moyen de rouleaux, de boules, p. ex. gonflables ou de chaînes ou de chaînes de rouleaux
The present invention features a method of manufacturing a tablet containing a pharmaceutically active agent by the steps of: (a) adding a powder containing a pharmaceutically-acceptable carrier to a die cavity; (b) injecting a liquid drug composition containing the pharmaceutically active agent into the die cavity such that the liquid drug composition contacts the powder; (c) compressing the combination of the powder and the liquid drug composition within the die cavity to form the tablet; and (d) removing the tablet from the die cavity.
A61K 31/19 - Acides carboxyliques, p. ex. acide valproïque
A61K 31/44 - Pyridines non condenséesLeurs dérivés hydrogénés
A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
The present invention is directed to an apparatus that includes a microcurrent delivery device portion and at least one independent sensory cue delivery means. The independent sensory cue delivery means can provide an independent sensory cue selected from the group consisting of vibration, heat, cool, skin irritation, tingling, fragrance or auditory.
A61N 1/32 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
A61N 1/34 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour provoquer l'anesthésie
A61N 1/20 - Application de courants électriques par électrodes de contact courants continus ininterrompus
A61N 1/24 - Ceintures électromédicales avec source de courant incorporée
The present invention features an orally disintegrating dosage form including from about 5% to about 40%, by weight, of at least one hydrated salt and a pharmaceutically active agent, wherein the at least hydrated salt has a dehydration temperature of from about 20 to about 120 °C.
The present invention is directed to a topical composition comprising a counterirritant active ingredient and a sensate that povides a cooling sensation to the skin that is topically perceptible to an adult human subject for greater than about 90 minutes, e.g. greater than about 120 minutes, say greater than about 150 minutes, when applied in an effective amount over an area on the back of a hand, elbow, lower back or shoulder region. In one embodiment, the sensate can be encapsulated. The sensate can alternatively be bound to an ion exchange resin or adsorbed onto an adsorbant.
Apparatus for knotting at least one string of material has a fixed knotter plate, a primary knotter plate, a secondary knotter plate, means to apply tension to the string, and means for threading the string through the knotter plates.
In one aspect, the present invention features a method of making a coated tablet, by dipping a core including an active agent into a coating liquid and drying the dipped core to form a outer-coating on said core, wherein the coating liquid includes (i) at least one copolymer of polyvinyl alcohol and polyethylene glycol, (ii) at least one gum, and (iii) a solvent for the at least one copolymer of polyvinyl alcohol and polyethylene glycol and the at least one gum and coated tablets manufactured by such method.
The present invention relates to a process for manufacturing gelatin products that have improved stability, particularly as to the dissolution rates and/or reduced degree of crosslinking and the gelatin formulations per se. A further aspect of the invention is use of the improved gelatin compositions for use as a coating for dosage forms or dosage form inserts.
A method of administering non-steroidal-anti-inflammatory drugs, in particular propionic acid derivatives such as ibuprofen, is provided. The inventive dosage forms provide an initial release of the NSAID and a second sustained release of NSAID, preferably in a single dosing step.
A61K 9/28 - DragéesPilules ou comprimés avec revêtements
A61K 31/19 - Acides carboxyliques, p. ex. acide valproïque
A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
The present invention relates to a medicinal dosage form having a first core, a second core, and a shell that surrounds a first portion of each core and a fill material that covers a second portion of at least one core, wherein the fill material that is provided over at least one core is not in contact with any portion of the other core, e. The inventive dosage forms provide modified release of one or more active ingredients contained therein. The present invention also relates to methods for manufacturing such medicinal dosage forms.
The present invention relates to a process for stabilizing phenylephrine including drying an acidic solution of phenylephrine and pharmaceutical compositions including stabilized phenylephrine.
The present invention relates to a dosage form including both a disintegrative tablet portion and a hard candy portion, wherein: (i) the disintegrative tablet portion comprises at least one pharmaceutically active agent, and (ii) the hard candy portion covers at least 20% of the surface of the disintegrative tablet portion, and wherein the disintegration time of the hard candy portion is at least ten times longer than the disintegration time of the disintegrative tablet portion.
The present invention relates to a coated dosage form having openings to expose the core material or an intermediate coating layer. The invention also relates to methods for manufacturing such coated dosage forms.
