G01N 33/86 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir le temps de coagulation du sang
G01N 33/00 - Recherche ou analyse des matériaux par des méthodes spécifiques non couvertes par les groupes
G01N 33/49 - Analyse physique de matériau biologique de matériau biologique liquide de sang
Provided are assay devices, methods and microfluidic cartridges for analysis of fluids, such as whole blood. A fibrinogen assay cartridge is adapted to measure whole blood flow rates on exposure to thrombin and measures hematocrit for a plasma fibrinogen calculation. Multiple channel cartridges are provided to allow determination of multiple assays (e.g., coagulation panel) from a single sample on a single cartridge.
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
G01N 33/49 - Analyse physique de matériau biologique de matériau biologique liquide de sang
G01N 33/86 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir le temps de coagulation du sang
Analytical cartridges, systems and methods of processing a sample for analysis using capillary flows. Vertical gradient sample filtration provides filtrate to an incubation chamber for a time controlled by a flow modulator at the outlet of the incubation chamber. The flow modulator can include a serpentine capillary flow path without side walls. Incubated filtrate can flow from the incubation chamber to a detection channel after a predetermined time. The detection chamber can include one or more analytical regions in a porous substrate for detection of two or more analytes on the same cartridge from the same sample.
G01N 33/558 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet utilisant la diffusion ou la migration de l'anticorps ou de l'antigène
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
Medical devices, namely, diagnostic chips to diagnose
myocardial infarction, congestive heart failure, heart
failure, acute coronary syndrome, tumor, virus, pulmonary
thromboembolism, deep vein thrombosis, and spectrometer to
be used in connection with said diagnostic chips.
Medical devices, namely, diagnostic chips to diagnose myocardial infarction, congestive heart failure, heart failure, acute coronary syndrome, tumor, virus, pulmonary thromboembolism, deep vein thrombosis, and spectrometer to be used in connection with said diagnostic chips
In some examples, a device applies an electrical potential difference across a blood sample. The device measures an electrical signal that passes through the blood sample over a duration of time to obtain a plurality of measurements representing a measurement function of time. An accumulative property of the measurement function may be determined such that the accumulative property correlates to a blood coagulation characteristic.
G01N 33/86 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir le temps de coagulation du sang
G01N 33/49 - Analyse physique de matériau biologique de matériau biologique liquide de sang
G01N 27/26 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant des variables électrochimiquesRecherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en utilisant l'électrolyse ou l'électrophorèse
In some examples, a device applies an electrical potential difference across a blood sample. The device measures an electrical signal that passes through the blood sample over a duration of time to obtain a plurality of measurements representing a measurement function of time. An accumulative property of the measurement function may be determined such that the accumulative property correlates to a blood coagulation characteristic.
G01N 33/86 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir le temps de coagulation du sang
G01N 33/49 - Analyse physique de matériau biologique de matériau biologique liquide de sang
G01N 27/26 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant des variables électrochimiquesRecherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en utilisant l'électrolyse ou l'électrophorèse
This invention provides methods and devices to measure physical characteristics of sample fluids. Samples are introduced into a sample chamber in contact with a mechanically oscillating working member. The vibrations are received by a piezoelectric sensor transducer and correlated to a sample characteristic, such as viscosity or density. The devices include a sample chamber in contact with one or more working members actuated by a piezoelectric actuator and/or monitored by a piezoelectric sensor.
G01N 27/02 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance
G01N 33/86 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir le temps de coagulation du sang
A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
G01N 33/49 - Analyse physique de matériau biologique de matériau biologique liquide de sang
This invention provides methods and devices for detecting the viscosity and conductivity of a conductive fluid sample. A sample fluid can be received into a sample chamber between a field inductor and sensor inductor. Electromagnetic fields generated by the field inductor can be modulated due to the counter-emf induced in the sample. The modulations can be detected by the sensor inductor and correlated to electric parameters in the fluid.
G01N 27/02 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance
G01N 33/86 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir le temps de coagulation du sang
G01N 33/49 - Analyse physique de matériau biologique de matériau biologique liquide de sang
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
This invention provides methods of array reading and readers of assay result arrays wherein light can be scanned onto analytical region array members from a light source and/or light can be scanned from array members to a detector. One or more mirrors can have one of more pivotable axes enabling scanning light paths to be established between assay result arrays and other components of an analytical device.
Medical devices, namely, medical monitoring apparatus comprising analyzers, disposable devices, reagents, software, manuals and accessories such as test calibrators, controls and sample handling equipment, used for the diagnosis of chronic and acute conditions or infections pertaining to cardiovascular health, diabetes, blood glucose, blood lipid, blood chemistry, coagulation time, female health, tumor markers and sepsis
Analytical cartridges, systems and methods of processing a sample for analysis using capillary flows. Vertical gradient sample filtration provides filtrate to an incubation chamber for a time controlled by a flow modulator at the outlet of the incubation chamber. The flow modulator can include a serpentine capillary flow path without side walls. Incubated filtrate can flow from the incubation chamber to a detection channel after a predetermined time. The detection chamber can include one or more analytical regions in a porous substrate for detection of two or more analytes on the same cartridge from the same sample.
G01N 35/08 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet en utilisant un courant d'échantillons discrets circulant dans une canalisation, p. ex. analyse à injection dans un écoulement
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
B01L 99/00 - Matière non prévue dans les autres groupes de la présente sous-classe
G01N 1/38 - Dilution, dispersion ou mélange des échantillons
Medical devices, namely, diagnostic chips to diagnose myocardial infarction, congestive heart failure, heart failure, acute coronary syndrome, tumor, virus, pulmonary thromboembolism, deep vein thrombosis, and spectrometer to be used in connection with said diagnostic chips
15.
RAPID AND EFFICIENT FILTERING WHOLE BLOOD IN A CAPILLARY FLOW DEVICE
This invention provides lateral flow filters with pore size gradients and with features to prevent peripheral flows around the filter. The filters can be laminated composites of two or more planar filter layers. Cartridges employing the filters can include a filtration chamber configured to retain the lateral flow filters including a port for sample application and a capillary channel for filtrate egress. The fluid egress port can be positioned to receive filtrate from one filter layer but not another.
This invention relates to a systems and methods of controlling the flow of a fluid in a capillary or microfluidic channel. A first pair of electrodes can influence the wetting of a fluid front at a relatively hydrophobic surface in the channel. A second pair of electrodes can electrolytically generate a bubble that can stop fluid flow when it contacts the hydrophobic surface. Flow of a fluid in a channel can be stopped on contact with the hydrophobic surface and restarted when an electrostatic field reduces the contact angle of the fluid at the hydrophobic surface. The electrostatic field can be removed and the fluid stopped again when an electrolytically generated bubble contacts the hydrophobic surface to reestablish the blocking contact angle of the fluid, gas and surface.
This invention relates to micromachined fluid ejector arrays having a fluid reservoir bounded at one side by an elastic membrane having scalable arrays of orifices arranged between concentric piezoelectric transducers, and bounded at another side by a top cover supported by surrounding walls. By actuating neighbonng concentric piezoelectric transducers, the scalable array of orifices arranged between the actuated neighboring concentric piezoelectric transducers deflect to eject fluid droplets. Also disclosed is a micromachined fluid ejector array having a fluid reservoir bounded at one side by an elastic membrane having scalable arrays of orifices arranged between concentric piezoelectric transducers, and at another side by a top cover supported by surrounding walls with a piezoelectric layer bonded on top of the top cover. By actuating the piezoelectric layer, the scalable arrays of orifices arranged between the neighboring concentric piezoelectric transducers deflect in phase to eject fluid droplets.
B05B 1/08 - Buses, têtes de pulvérisation ou autres dispositifs de sortie, avec ou sans dispositifs auxiliaires tels que valves, moyens de chauffage agencés pour produire un jet, un pulvérisat ou tout autre écoulement de forme ou de nature particulière, p. ex. sous forme de gouttes individuelles de nature pulsatoire, p. ex. débitant un liquide en quantités successives séparées
