Systems, catheters, and methods for accessing and treating along the central nervous system are disclosed. An example system may include a system for ameliorating a symptom of bacterial meningitis in a patient. The system may include a catheter assembly having a first lumen with a distal port and a second lumen with a proximal port, said catheter being adapted to be introduced in a CSF space and said ports being spaced axially apart. A pump may be connectable between the first and second lumens to induce a flow of CSF therebetween. A filter component may be connectable between the first and second lumens. The filter component may be configured to remove one or more meningitis causing bacterial pathogen from the CSF, to thereby condition the cerebrospinal fluid.
Devices and methods for ablating tissue are disclosed. A method for ablating tissue includes applying a first radio frequency ablation current to a target tissue and applying a second radio frequency ablation current to the target tissue. Additionally, the ratio of the frequency of the first radio frequency ablation current to the second radio frequency ablation current is in the range of 1:2 to 1:400.
A61N 1/06 - Électrodes pour traitement à haute fréquence
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
A61B 18/12 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage en faisant passer des courants à travers les tissus à chauffer, p. ex. des courants à haute fréquence
The present invention provides methods and systems for conditioning cerebrospinal fluid (CSF) by removing target compounds from CSF. The systems provide for a catheter flow path and exchange of a majority volume portion of CSF in the CSF space. The removal and/or delivery of specific compounds can be tailored to the pathology of the specific disease. The removal is targeted and specific, for example, through the use of specific size-exclusion thresholds, antibodies against specific toxins, and other chromatographic techniques, as well as delivery and/or removal of targeted therapeutic agents.
The present invention provides methods and systems for conditioning cerebrospinal fluid (CSF) by removing target compounds from CSF. The systems provide for a catheter flow path and exchange of a majority volume portion of CSF in the CSF space. The removal and/or delivery of specific compounds can be tailored to the pathology of the specific disease. The removal is targeted and specific, for example, through the use of specific size-exclusion thresholds, antibodies against specific toxins, and other chromatographic techniques, as well as delivery and/or removal of targeted therapeutic agents.
Systems and methods for systems and methods for focal cooling of the brain and spinal cord are disclosed. Some embodiments may be directed to a neuroprotection system that includes a cerebrospinal fluid processing platform. Embodiments may provide rapid and selective spinal cord hypothermia and drainage. Embodiments may be tailored to selective spinal cord cooling, pressure monitoring and automated drainage. Embodiments may enable local hypothermic neuroprotection, limit the stress of systemic cooling, minimize secondary neuronal damage and achieve maximal neuroprotection while at the same time improving workflow as a result of automated drainage. Embodiments may to include a multi-lumen catheter, a drainage collection reservoir bag, a pump to circulate coolant, sensor hardware and controllers to modulate the flow of a heat transfer fluid for cooling to modulate therapeutic hypothermia and re-warming. Certain embodiments may include extracorporeal cooling of cerebrospinal fluid (CSF). Certain embodiments may include circulating heat transfer fluid within a CSF-containing space near the brain or spinal cord using a catheter. Particular methods may be used to determine the length and amount of cooling.
The present invention provides methods and systems for conditioning cerebrospinal fluid (CSF) by removing target compounds from CSF. The systems provide for a catheter flow path and exchange of a majority volume portion of CSF in the CSF space. The removal and/or delivery of specific compounds can be tailored to the pathology of the specific disease. The removal is targeted and specific, for example, through the use of specific size-exclusion thresholds, antibodies against specific toxins, and other chromatographic techniques, as well as delivery and/or removal of targeted therapeutic agents.
Disclosed are systems and methods for use of an inductive link for a communication channel in a transcutaneous energy transfer system. An example system may include a resonant circuit associated with an external primary, a power transistor connected to the resonant circuit and configured to drive the resonant circuit with a first time-varying electrical signal having a frequency, and a power driver connected to the power transistor that is configured to set the frequency of the first time-varying electrical signal to a resonant frequency to enable power transfer from the external primary to an implanted secondary. The example system may further include a communication driver operatively connected to the power transistor and configured to encode the first time-varying electrical signal with a data signal by modulating an attribute of the time-varying electrical signal as electrical power is transferred from the external primary to the implanted secondary.
A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs
A61M 60/148 - Pompes ou dispositifs de pompage implantables, c.-à-d. que le sang est pompé à l’intérieur du corps du patient implantables par, dans, à l’intérieur, en ligne, se ramifiant dans ou autour d’un vaisseau sanguin en ligne avec un vaisseau sanguin par résection ou techniques analogues, p. ex. dispositifs permanents d’assistance cardiaque endovasculaire
A61M 60/205 - Pompes pour le sang à déplacement non positif
Disclosed is a distributed transformer or extension cord component for a transcutaneous energy transfer system used to transfer electric power to an implanted medical device. The extension cord component may enable power transfer to occur at various points on or near the body of the subject within whom the medical device is implanted. In this way, the subject may gain greater flexibility and high levels of convenience in connection with use of the transcutaneous energy transfer system.
H02J 7/02 - Circuits pour la charge ou la dépolarisation des batteries ou pour alimenter des charges par des batteries pour la charge des batteries par réseaux à courant alternatif au moyen de convertisseurs
H02J 50/50 - Circuits ou systèmes pour l'alimentation ou la distribution sans fil d'énergie électrique utilisant des répéteurs d’énergie supplémentaires entre les dispositifs de transmission et les dispositifs de réception
A61M 60/122 - Pompes ou dispositifs de pompage implantables, c.-à-d. que le sang est pompé à l’intérieur du corps du patient
A61M 60/148 - Pompes ou dispositifs de pompage implantables, c.-à-d. que le sang est pompé à l’intérieur du corps du patient implantables par, dans, à l’intérieur, en ligne, se ramifiant dans ou autour d’un vaisseau sanguin en ligne avec un vaisseau sanguin par résection ou techniques analogues, p. ex. dispositifs permanents d’assistance cardiaque endovasculaire
A61M 60/205 - Pompes pour le sang à déplacement non positif
A61M 60/274 - Pompes pour le sang à déplacement positif comportant un élément de déplacement agissant directement sur le sang l’élément de déplacement étant souple, p. ex. membranes, diaphragmes ou vessies l’entrée et la sortie étant identiques, p. ex. pompes pour le sang à contre-pulsation para-aortique
Devices and methods for ablating tissue are disclosed. A method for ablating tissue includes applying a first radio frequency ablation current to a target tissue and applying a second radio frequency ablation current to the target tissue. Additionally, the ratio of the frequency of the first radio frequency ablation current to the second radio frequency ablation current is in the range of 1:2 to 1:400.
A61B 18/12 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage en faisant passer des courants à travers les tissus à chauffer, p. ex. des courants à haute fréquence
A61N 1/06 - Électrodes pour traitement à haute fréquence
A61N 1/40 - Application de champs électriques par couplage inductif ou capacitif
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
Devices and methods for ablating tissue are disclosed. A method for ablating tissue includes applying a first radio frequency ablation current to a target tissue and applying a second radio frequency ablation current to the target tissue. Additionally, the ratio of the frequency of the first radio frequency ablation current to the second radio frequency ablation current is in the range of 1:2 to 1:400.
A61B 18/12 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage en faisant passer des courants à travers les tissus à chauffer, p. ex. des courants à haute fréquence
A repeater for a wireless power transfer system is disclosed. The repeaters includes an elongated strip of material arranged in a substantially circular configuration with opposing ends of the elongated strip disposed in close proximity to each other, an inductive element associated with the elongated strip and arranged to provide a coupling with an adjacent resonator through flux directed outward from a first surface of the elongated strip, and a capacitive element associated with the elongated strip and arranged to resonate electromagnetic energy with the inductive element when the electromagnetic energy is transferred from the adjacent resonator through the coupling provided by the inductive element.
H02J 50/50 - Circuits ou systèmes pour l'alimentation ou la distribution sans fil d'énergie électrique utilisant des répéteurs d’énergie supplémentaires entre les dispositifs de transmission et les dispositifs de réception
A61M 60/148 - Pompes ou dispositifs de pompage implantables, c.-à-d. que le sang est pompé à l’intérieur du corps du patient implantables par, dans, à l’intérieur, en ligne, se ramifiant dans ou autour d’un vaisseau sanguin en ligne avec un vaisseau sanguin par résection ou techniques analogues, p. ex. dispositifs permanents d’assistance cardiaque endovasculaire
H02J 50/12 - Circuits ou systèmes pour l'alimentation ou la distribution sans fil d'énergie électrique utilisant un couplage inductif du type couplage à résonance
A61M 60/873 - Dispositifs d’alimentation en énergieConvertisseurs à cet effet spécialement adaptés au transfert d’énergie sans fil ou transcutané, p. ex. à la charge par induction
Present embodiments are directed to measuring and calculating parameters to control and monitor a power transfer in an implanted medical device. The medical device may be implanted in a subject and typically includes an artificial heart or ventricle assist device. The system measures parameters and uses the parameters to calculate a coupling coefficient for coils that transfer power between an external primary and an implanted secondary. The system uses the calculated coupling coefficient to estimate heat flux being generated in the system. Based on the level heat flux detected, the system may issue alerts to warn the subject or control actions to mitigate the effects of the heat flux.
A61M 1/12 - Pompes pour le sang; Cœurs artificiels; Dispositifs pour aider mécaniquement la circulation, p.ex. pompes à ballon intra-aortique implantables dans le corps
A61M 1/10 - Pompes pour le sang; Cœurs artificiels; Dispositifs pour aider mécaniquement la circulation, p.ex. pompes à ballon intra-aortique
G01K 7/36 - Mesure de la température basée sur l'utilisation d'éléments électriques ou magnétiques directement sensibles à la chaleur utilisant des éléments magnétiques, p. ex. des aimants, des bobines
G01K 7/42 - Circuits pour la compensation de l’inertie thermiqueCircuits pour prévoir la valeur stationnaire de la température
G01K 13/00 - Thermomètres spécialement adaptés à des fins spécifiques
Systems, catheters, and methods for accessing and treating along the central nervous system are disclosed. An example system may include a system for ameliorating a symptom of bacterial meningitis in a patient. The system may include a catheter assembly having a first lumen with a distal port and a second lumen with a proximal port, said catheter being adapted to be introduced in a CSF space and said ports being spaced axially apart. A pump may be connectable between the first and second lumens to induce a flow of CSF therebetween. A filter component may be connectable between the first and second lumens. The filter component may be configured to remove one or more meningitis causing bacterial pathogen from the CSF, to thereby condition the cerebrospinal fluid.
Systems, catheters, and methods for accessing and treating along the central nervous system are disclosed. An example system may include a system for ameliorating a symptom of bacterial meningitis in a patient. The system may include a catheter assembly having a first lumen with a distal port and a second lumen with a proximal port, said catheter being adapted to be introduced in a CSF space and said ports being spaced axially apart. A pump may be connectable between the first and second lumens to induce a flow of CSF therebetween. A filter component may be connectable between the first and second lumens. The filter component may be configured to remove one or more meningitis causing bacterial pathogen from the CSF, to thereby condition the cerebrospinal fluid.
Examples described herein may include medical devices and electrosurgical generators with resonant isolated transformers to perform filtering and gain functions. An example electrosurgical generator includes a radio frequency (RF) inverter stage configured to receive an input signal and, in response to control feedback signals, to provide an output signal that provides power to a load. The RF inverter stage includes a resonant isolated transformer configured to receive the input signal and to provide gain and filtering adjustments to the input signal to provide the output signal.
A61B 18/12 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage en faisant passer des courants à travers les tissus à chauffer, p. ex. des courants à haute fréquence
H02M 7/5387 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant alternatif sans possibilité de réversibilité par convertisseurs statiques utilisant des tubes à décharge avec électrode de commande ou des dispositifs à semi-conducteurs avec électrode de commande utilisant des dispositifs du type triode ou transistor exigeant l'application continue d'un signal de commande utilisant uniquement des dispositifs à semi-conducteurs, p. ex. onduleurs à impulsions à un seul commutateur dans une configuration en pont
H02M 1/12 - Dispositions de réduction des harmoniques d'une entrée ou d'une sortie en courant alternatif
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
H02M 7/48 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant alternatif sans possibilité de réversibilité par convertisseurs statiques utilisant des tubes à décharge avec électrode de commande ou des dispositifs à semi-conducteurs avec électrode de commande
16.
CONTROL AND INVERTER DESIGN TOPOLOGIES FOR ELECTRONIC MEDICAL DEVICES
Examples described herein may include medical devices and electrosurgical generators with resonant isolated transformers to perform filtering and gain functions. An example electrosurgical generator includes a radio frequency (RF) inverter stage configured to receive an input signal and, in response to control feedback signals, to provide an output signal that provides power to a load. The RF inverter stage includes a resonant isolated transformer configured to receive the input signal and to provide gain and filtering adjustments to the input signal to provide the output signal.
A61B 18/18 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par application de radiations électromagnétiques, p. ex. de micro-ondes
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
Disclosed are systems and methods for measuring and calculating parameters to control and monitor a power transfer in an implanted medical device, including operating the device in a plurality of scalable power modes and/or coupling modes. The system may shift between or among power and/or coupling modes based on input such as data received over system communication lines, programmable timers, or electrical loading information. The system may also shift between or among power and/or coupling modes based on calculated amounts of coupling, levels of detected heat flux, and/or amounts of estimated temperature changes.
A61M 1/10 - Pompes pour le sang; Cœurs artificiels; Dispositifs pour aider mécaniquement la circulation, p.ex. pompes à ballon intra-aortique
A61M 1/12 - Pompes pour le sang; Cœurs artificiels; Dispositifs pour aider mécaniquement la circulation, p.ex. pompes à ballon intra-aortique implantables dans le corps
H02J 50/12 - Circuits ou systèmes pour l'alimentation ou la distribution sans fil d'énergie électrique utilisant un couplage inductif du type couplage à résonance
H02J 7/02 - Circuits pour la charge ou la dépolarisation des batteries ou pour alimenter des charges par des batteries pour la charge des batteries par réseaux à courant alternatif au moyen de convertisseurs
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Medical devices, namely, fluid filtration devices for the removal of substances from bodily fluids through extracorporeal filtration. Medical services, namely, spinal fluid treatment therapy for the treatment of diseases of the central nervous system.
The present invention provides methods and systems for conditioning cerebrospinal fluid (CSF) by removing target compounds from CSF. The systems provide for a catheter flow path and exchange of a majority volume portion of CSF in the CSF space. The removal and/or delivery of specific compounds can be tailored to the pathology of the specific disease. The removal is targeted and specific, for example, through the use of specific size-exclusion thresholds, antibodies against specific toxins, and other chromatographic techniques, as well as delivery and/or removal of targeted therapeutic agents.
Systems and methods for treating biologic fluids are disclosed. Some disclosed embodiments may be used to filter cerebrospinal fluid (CSF) from a human or animal subject, heat CSF to a target temperature, cool CSF to a target temperature, apply light treatment to CSF, separate cells via their dielectric properties, apply spiral and/or centrifugal separation, introduce additives to target particles, and/or apply combinations thereof. The method may include the steps of withdrawing fluid comprising CSF, treating the fluid, and returning a portion of the treated fluid to the subject. During operation of the system, various parameters may be modified, such as flow rate.
A61M 1/00 - Dispositifs de succion ou de pompage à usage médicalDispositifs pour retirer, traiter ou transporter les liquides du corpsSystèmes de drainage
A61M 1/34 - Filtration du sang à travers une membrane pour en éliminer une matière, c.-à-d. hémofiltration, diafiltration
A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p. ex. adaptation de la température, irradiation
A61M 27/00 - Appareillage pour drainage des blessures
G01N 33/48 - Matériau biologique, p. ex. sang, urineHémocytomètres
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
21.
DEVICES AND METHODS FOR PROVIDING FOCAL COOLING TO THE BRAIN AND SPINAL CORD
Embodiments may include extracorporeal cooling of cerebrospinal fluid (CSF) or circulating heat transfer fluid within a catheter in the CSF-containing space.
A61B 18/02 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par refroidissement, p. ex. techniques cryogéniques
A61M 27/00 - Appareillage pour drainage des blessures
Systems and methods for filtering materials from biologic fluids are discussed. Embodiments may be used to filter cerebrospinal fluid (CSF) from a human or animal subject. The method may include the steps of withdrawing fluid comprising CSF, filtering the volume into permeate and retentate by passing the fluid through a tangential flow filter, and returning the permeate to the subject. During operation of the system, various parameters may be modified, such as flow rate.
A61M 1/00 - Dispositifs de succion ou de pompage à usage médicalDispositifs pour retirer, traiter ou transporter les liquides du corpsSystèmes de drainage
B01D 61/00 - Procédés de séparation utilisant des membranes semi-perméables, p. ex. dialyse, osmose ou ultrafiltrationAppareils, accessoires ou opérations auxiliaires, spécialement adaptés à cet effet
A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs
A61M 1/12 - Pompes pour le sang; Cœurs artificiels; Dispositifs pour aider mécaniquement la circulation, p.ex. pompes à ballon intra-aortique implantables dans le corps
H04B 3/54 - Systèmes de transmission par lignes de réseau de distribution d'énergie
Disclosed is a distributed transformer or extension cord component for a transcutaneous energy transfer system used to transfer electric power to an implanted medical device. The extension cord component may enable power transfer to occur at various points on or near the body of the subject within whom the medical device is implanted. In this way, the subject may gain greater flexibility and high levels of convenience in connection with use of the transcutaneous energy transfer system.
A61M 1/12 - Pompes pour le sang; Cœurs artificiels; Dispositifs pour aider mécaniquement la circulation, p.ex. pompes à ballon intra-aortique implantables dans le corps
H02J 7/02 - Circuits pour la charge ou la dépolarisation des batteries ou pour alimenter des charges par des batteries pour la charge des batteries par réseaux à courant alternatif au moyen de convertisseurs
H02J 50/50 - Circuits ou systèmes pour l'alimentation ou la distribution sans fil d'énergie électrique utilisant des répéteurs d’énergie supplémentaires entre les dispositifs de transmission et les dispositifs de réception
A61M 1/10 - Pompes pour le sang; Cœurs artificiels; Dispositifs pour aider mécaniquement la circulation, p.ex. pompes à ballon intra-aortique
Present embodiments are directed to measuring and calculating parameters to control and monitor a power transfer in an implanted medical device. The medical device may be implanted in a subject and typically includes an artificial heart or ventricle assist device. The system measures parameters and uses the parameters to calculate a coupling coefficient for coils that transfer power between an external primary and an implanted secondary. The system uses the calculated coupling coefficient to estimate heat flux being generated in the system. Based on the level heat flux detected, the system may issue alerts to warn the subject or control actions to mitigate the effects of the heat flux.
A61M 1/12 - Pompes pour le sang; Cœurs artificiels; Dispositifs pour aider mécaniquement la circulation, p.ex. pompes à ballon intra-aortique implantables dans le corps
G01K 7/36 - Mesure de la température basée sur l'utilisation d'éléments électriques ou magnétiques directement sensibles à la chaleur utilisant des éléments magnétiques, p. ex. des aimants, des bobines
G01K 7/42 - Circuits pour la compensation de l’inertie thermiqueCircuits pour prévoir la valeur stationnaire de la température
G01K 13/00 - Thermomètres spécialement adaptés à des fins spécifiques
Disclosed are systems and methods for measuring and calculating parameters to control and monitor a power transfer in an implanted medical device, including operating the device in a plurality of scalable power modes and/or coupling modes. The system may shift between or among power and/or coupling modes based on input such as data received over system communication lines, programmable timers, or electrical loading information. The system may also shift between or among power and/or coupling modes based on calculated amounts of coupling, levels of detected heat flux, and/or amounts of estimated temperature changes.
A61M 1/12 - Pompes pour le sang; Cœurs artificiels; Dispositifs pour aider mécaniquement la circulation, p.ex. pompes à ballon intra-aortique implantables dans le corps
H02J 50/12 - Circuits ou systèmes pour l'alimentation ou la distribution sans fil d'énergie électrique utilisant un couplage inductif du type couplage à résonance
A61M 1/10 - Pompes pour le sang; Cœurs artificiels; Dispositifs pour aider mécaniquement la circulation, p.ex. pompes à ballon intra-aortique
H02J 7/02 - Circuits pour la charge ou la dépolarisation des batteries ou pour alimenter des charges par des batteries pour la charge des batteries par réseaux à courant alternatif au moyen de convertisseurs
A pump for inducing flow within a vascular system comprises two inlets. The pump has a first configuration for deployment within the vascular system and a second, operable configuration for directing the fluid flow within the vascular system, where the second configuration has a greater diameter than the first configuration. A centrifugal impeller is configured to induce the fluid flow by rotation about an axis of rotation, where the flow is in a direction generally transverse to the impeller's axis of rotation.
A61M 1/10 - Pompes pour le sang; Cœurs artificiels; Dispositifs pour aider mécaniquement la circulation, p.ex. pompes à ballon intra-aortique
A61M 1/12 - Pompes pour le sang; Cœurs artificiels; Dispositifs pour aider mécaniquement la circulation, p.ex. pompes à ballon intra-aortique implantables dans le corps
28.
Portable controller with integral power source for mechanical circulation support systems
A portable external device for a mechanical circulation support system includes first and second power sources, e.g. batteries and control electronics for redundant uninterrupted operation of an implantable blood pump. The control and power source module may be configured to accommodate a variety of wearable configurations for patient convenience and comfort.
G05B 19/10 - Commande à programme autre que la commande numérique, c.-à-d. dans des automatismes à séquence ou dans des automates à logique utilisant des sélecteurs
A61M 1/10 - Pompes pour le sang; Cœurs artificiels; Dispositifs pour aider mécaniquement la circulation, p.ex. pompes à ballon intra-aortique
A61M 1/12 - Pompes pour le sang; Cœurs artificiels; Dispositifs pour aider mécaniquement la circulation, p.ex. pompes à ballon intra-aortique implantables dans le corps
29.
Portable controller with integral power source for mechanical circulation support systems
A portable external device for a mechanical circulation support system includes first and second power sources, e.g. batteries and control electronics for redundant uninterrupted operation of an implantable blood pump. The control and power source module may be configured to accommodate a variety of wearable configurations for patient convenience and comfort.
G05B 19/10 - Commande à programme autre que la commande numérique, c.-à-d. dans des automatismes à séquence ou dans des automates à logique utilisant des sélecteurs
The present invention provides methods and systems for conditioning cerebrospinal fluid (CSF) by removing target compounds from CSF. The systems provide for a multilumen flow path and exchange of a majority volume portion of CSF in the CSF space. The removal and/or delivery of specific compounds can be tailored to the pathology of the specific disease. The removal is targeted and specific, for example, through the use of specific size-exclusion thresholds, antibodies against specific toxins, and other chromatographic techniques, as well as delivery and/or removal of targeted therapeutic agents.
A61M 1/00 - Dispositifs de succion ou de pompage à usage médicalDispositifs pour retirer, traiter ou transporter les liquides du corpsSystèmes de drainage
A61M 27/00 - Appareillage pour drainage des blessures
A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p. ex. adaptation de la température, irradiation
A pump for inducing flow within a vascular system comprises two inlets. The pump has a first configuration for deployment within the vascular system and a second, operable configuration for directing the fluid flow within the vascular system, where the second configuration has a greater diameter than the first configuration. A centrifugal impeller is configured to induce the fluid flow by rotation about an axis of rotation, where the flow is in a direction generally transverse to the impeller's axis of rotation.
A61M 1/12 - Pompes pour le sang; Cœurs artificiels; Dispositifs pour aider mécaniquement la circulation, p.ex. pompes à ballon intra-aortique implantables dans le corps
A61M 1/10 - Pompes pour le sang; Cœurs artificiels; Dispositifs pour aider mécaniquement la circulation, p.ex. pompes à ballon intra-aortique
32.
Portable controller with integral power source for mechanical circulation support systems
A portable external device for a mechanical circulation support system includes first and second power sources, e.g. batteries and control electronics for redundant uninterrupted operation of an implantable blood pump. The control and power source module may be configured to accommodate a variety of wearable configurations for patient convenience and comfort.
A pump for inducing motion of a fluid, the pump including a cannula adjustable between an operable configuration having a first diameter and a deployment configuration having a substantially smaller second diameter. An impeller is rotatable within the cannula about an axis. The impeller includes an at least semi-rigid support for a flexible web, and is positionable with respect to the cannula the operable configuration and the deployment configuration, the operable configuration extending the web to a first radial distance from the axis and the deployment configuration collapsing the web to a second substantially smaller radial distance from the axis.
A61B 1/00 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments
34.
EXPANDABLE BLOOD PUMPS AND METHODS OF THEIR DEPLOYMENT AND USE
A pump for inducing motion of a fluid, the pump including a cannula adjustable between an operable configuration having a first diameter and a deployment configuration having a substantially smaller second diameter. An impeller is rotatable within the cannula about an axis. The impeller includes an at least semi-rigid support for a flexible web, and is positionable with respect to the cannula the operable configuration and the deployment configuration, the operable configuration extending the web to a first radial distance from the axis and the deployment configuration collapsing the web to a second substantially smaller radial distance from the axis.
A61M 1/10 - Pompes pour le sang; Cœurs artificiels; Dispositifs pour aider mécaniquement la circulation, p.ex. pompes à ballon intra-aortique
A61M 1/12 - Pompes pour le sang; Cœurs artificiels; Dispositifs pour aider mécaniquement la circulation, p.ex. pompes à ballon intra-aortique implantables dans le corps
A pump for inducing flow within a vascular system comprises a cannula having a first configuration for deployment within the vascular system and a second configuration for directing the fluid flow within the vascular system, where the second configuration has a greater diameter than the first configuration. An impeller is configured to induce the fluid flow by rotation about an axis. The impeller has a first radius in the first configuration and a second radius in the second configuration, where the second radius is greater than the first radius.
A61M 1/10 - Pompes pour le sang; Cœurs artificiels; Dispositifs pour aider mécaniquement la circulation, p.ex. pompes à ballon intra-aortique
A61M 1/12 - Pompes pour le sang; Cœurs artificiels; Dispositifs pour aider mécaniquement la circulation, p.ex. pompes à ballon intra-aortique implantables dans le corps
A pump for inducing flow within a vascular system comprises a cannula having a first configuration for deployment within the vascular system and a second configuration for directing the fluid flow within the vascular system, where the second configuration has a greater diameter than the first configuration. An impeller is configured to induce the fluid flow by rotation about an axis. The impeller has a first radius in the first configuration and a second radius in the second configuration, where the second radius is greater than the first radius.
A61M 1/12 - Pompes pour le sang; Cœurs artificiels; Dispositifs pour aider mécaniquement la circulation, p.ex. pompes à ballon intra-aortique implantables dans le corps
A61M 1/10 - Pompes pour le sang; Cœurs artificiels; Dispositifs pour aider mécaniquement la circulation, p.ex. pompes à ballon intra-aortique
09 - Appareils et instruments scientifiques et électriques
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Scientific, nautical, surveying, photographic, cinematographic, optical, weighing, measuring, signalling, checking (supervision), life-saving and teaching apparatus and instruments; apparatus for recording, transmission or reproduction of sound or images; magnetic data carriers, recording discs; mechanisms for coin-operated apparatus; cash registers, calculating machines, data processing equipment and computers; fire-extinguishing apparatus; computer hardware; computer software; computer hardware and software for remote device monitoring; computer hardware and software for monitoring, tracking, auditing, testing, diagnosing, upgrading, and troubleshooting capital equipment, medical equipment and medical devices; computer hardware and software for analyzing and forecasting customer demand, trends, and results of promotional activities; computer hardware and software for monitoring, controlling, auditing and transmitting data and software upgrades between computers and capital equipment, medical equipment and medical devices; computer hardware and software for inventory management; computer hardware and software for training and certifying users of capital equipment, medical equipment and medical devices; computer hardware and software for viewing warnings and faults, and reporting information for regulatory compliance in connection with medical tests and procedures. Custom Manufacturing of Medical Devices; Manufacturing Services for Others in the Field of Medical Devices. Design and Development of Microprocessors for Others for Industrial and Medical Applications; Providing Temporary Use of Web-Based Software and Temporary Use of Non-Downloadable Software for Remote Monitoring of Medical Capital Equipment, Medical Equipment, and Medical Devices, for Monitoring, Tracking, Auditing, Testing, Diagnosing, Upgrading, and Troubleshooting Medical Capital Equipment, Medical Equipment and Medical Devices, for Analyzing and Forecasting Customer Demand, Trends, and Results of Promotional Activities, for Monitoring, Controlling, Auditing and Transmitting Data and Software Upgrades Between Computers and Medical Capital Equipment, Medical Equipment and Medical Devices, for Inventory Management, for Training and Certifying Users of Medical Capital Equipment, Medical Equipment and Medical Devices, and for Viewing Warnings and Faults, and Reporting Information for Regulatory Compliance in Connection with Medical Tests and Procedures; Application Service Provider, Namely, Hosting, Managing, Developing, and Maintaining Applications, Software, and Web Sites, in the Fields of Remote Monitoring of Medical Capital Equipment, Medical Equipment, and Medical Devices, Monitoring, Tracking, Auditing, Testing, Diagnosing, Upgrading, and Troubleshooting Medical Capital Equipment, Medical Equipment and Medical Devices, Analyzing and Forecasting Customer Demand, Trends, and Results of Promotional Activities, and Monitoring, Controlling, Auditing and Transmitting Data and Software Upgrades Between Computers and Medical Capital Equipment, Medical Equipment and Medical Devices, Inventory Management, Training and Certifying Users of Medical Capital Equipment, Medical Equipment and Medical Devices, and Viewing Warnings and Faults, and Reporting Information for Regulatory Compliance in Connection with Medical Tests and Procedures for Wireless Delivery of Content to Handheld Computers, Laptops and Mobile Electronic Devices.
38.
PORTABLE CONTROLLER WITH INTEGRAL POWER SOURCE FOR MECHANICAL CIRCULATION SUPPORT SYSTEMS
A portable external device for a mechanical circulation support system includes first and second power sources, e.g. batteries and control electronics for redundant uninterrupted operation of an implantable blood pump. The control and power source module may be configured to accommodate a variety of wearable configurations for patient convenience and comfort.
A portable external device for a mechanical circulation support system includes first and second power sources, e.g. batteries and control electronics for redundant uninterrupted operation of an implantable blood pump. The control and power source module may be configured to accommodate a variety of wearable configurations for patient convenience and comfort.
G05B 19/10 - Commande à programme autre que la commande numérique, c.-à-d. dans des automatismes à séquence ou dans des automates à logique utilisant des sélecteurs
40.
PORTABLE CONTROLLER AND POWER SOURCE FOR MECHANICAL CIRCULATION SUPPORT SYSTEMS
A portable external device for a mechanical circulation support system includes first and second power sources, e.g. batteries and control electronics for redundant uninterrupted operation of an implantable blood pump. The control and power source module may be configured for variable form factors to accommodate a variety of wearable configurations for patient convenience and comfort.
A61M 1/12 - Pompes pour le sang; Cœurs artificiels; Dispositifs pour aider mécaniquement la circulation, p.ex. pompes à ballon intra-aortique implantables dans le corps
H05K 5/00 - Enveloppes, coffrets ou tiroirs pour appareils électriques
41.
PORTABLE CONTROLLER WITH INTEGRAL POWER SOURCE FOR MECHANICAL CIRCULATION SUPPORT SYSTEMS
A portable external device for a mechanical circulation support system includes first and second power sources, e.g. batteries and control electronics for redundant uninterrupted operation of an implantable blood pump. The control and power source module may be configured to accommodate a variety of wearable configurations for patient convenience and comfort.
A portable external device for a mechanical circulation support system includes first and second power sources, e.g. batteries and control electronics for redundant uninterrupted operation of an implantable blood pump. The control and power source module may be configured to accommodate a variety of wearable configurations for patient convenience and comfort.
A portable external device for a mechanical circulation support system includes first and second power sources, e.g. batteries and control electronics for redundant uninterrupted operation of an implantable blood pump. The control and power source module may be configured for variable form factors to accommodate a variety of wearable configurations for patient convenience and comfort.
A61M 1/12 - Pompes pour le sang; Cœurs artificiels; Dispositifs pour aider mécaniquement la circulation, p.ex. pompes à ballon intra-aortique implantables dans le corps
44.
Portable controller with integral power source for mechanical circulation support systems
A portable external device for a mechanical circulation support system includes first and second power sources, e.g. batteries and control electronics for redundant uninterrupted operation of an implantable blood pump. The control and power source module may be configured to accommodate a variety of wearable configurations for patient convenience and comfort.
A portable external device for a mechanical circulation support system includes first and second power sources, e.g. batteries and control electronics for redundant uninterrupted operation of an implantable blood pump. The control and power source module may be configured to accommodate a variety of wearable configurations for patient convenience and comfort.
09 - Appareils et instruments scientifiques et électriques
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Scientific, nautical, surveying, photographic, cinematographic, optical, weighing, measuring, signalling, checking (supervision), life-saving and teaching apparatus and instruments; apparatus for recording, transmission or reproduction of sound or images; magnetic data carriers, recording discs; automatic vending machines and mechanisms for coin-operated apparatus; cash registers, calculating machines, data processing equipment and computers; fire-extinguishing apparatus; computer hardware; computer software; computer hardware and software for remote device monitoring; computer hardware and software for monitoring, tracking, auditing, testing, diagnosing, upgrading, and troubleshooting capital equipment, medical equipment and medical devices; computer hardware and software for analyzing and forecasting customer demand, trends, and results of promotional activities; computer hardware and software for monitoring, controlling, auditing and transmitting data and software upgrades between computers and capital equipment, medical equipment and medical devices; computer hardware and software for inventory management; computer hardware and software for training and certifying users of capital equipment, medical equipment and medical devices; computer hardware and software for viewing warnings and faults, and reporting information for regulatory compliance in connection with medical tests and procedures. Treatment of materials; custom manufacture of medical devices. Scientific and technological services and research and design relating thereto; industrial analysis and research services; design and development of computer hardware and software; computer programming; design and development of microprocessors for others for industrial and medical applications; design and development of computer hardware for others; computer programming and software design for others; providing web-based software and temporary use of non-downloadable software for remote device monitoring, for monitoring, tracking, auditing, testing, diagnosing, upgrading, and troubleshooting capital equipment, medical equipment and medical devices, for analyzing and forecasting customer demand, trends, and results of promotional activities, for monitoring, controlling, auditing and transmitting data and software upgrades between computers and capital equipment, medical equipment and medical devices, for inventory management, for training and certifying users of capital equipment, medical equipment and medical devices, and for viewing warnings and faults, and reporting information for regulatory compliance in connection with medical tests and procedures; installation and repair of computer software, including mobile performance of such services; application service provider, namely, hosting, managing, developing, and maintaining applications, software, and web sites, in the fields of remote device monitoring, monitoring, tracking, auditing, testing, diagnosing, upgrading, and troubleshooting capital equipment, medical equipment and medical devices, analyzing and forecasting customer demand, trends, and results of promotional activities, and monitoring, controlling, auditing and transmitting data and software upgrades between computers and capital equipment, medical equipment and medical devices, inventory management, training and certifying users of capital equipment, medical equipment and medical devices, and viewing warnings and faults, and reporting information for regulatory compliance in connection with medical tests and procedures for wireless delivery of content to handheld computers, laptops and mobile electronic devices.
The present invention provides methods and systems for conditioning cerebrospinal fluid (CSF) by removing target compounds from CSF. A multilumen flow path allows exchange of a majority volume portion of CSF in the CSF space. The removal and/or delivery of specific compounds can be tailored to the pathology of the specific disease. The removal is targeted and specific, for example, through the use of specific size-exclusion thresholds, antibodies against specific toxins, and other chromatographic techniques, as well as delivery and/or removal of targeted therapeutic agents.
A61M 1/00 - Dispositifs de succion ou de pompage à usage médicalDispositifs pour retirer, traiter ou transporter les liquides du corpsSystèmes de drainage
48.
PROGRAMMABLE SYSTEM FOR CONDITIONING OF CEREBROSPINAL FLUID
A programmable system (10) to control the extracorporeal circulation and conditioning of cerebrospinal fluid for the treatment of brain maladies. The system (10) includes an extracorporeal fluid circuit (30) with pressure sensors (41, 42, 43), compositional analysis units (45), pumps (65, 72) and medicament dispensers (80) as well as a controller (100) which synchronizes the automated sensing, analysis and conditioning functions with the operation of the pumping system (65, 72) so as to increase the precision of the measurements and optimize the effectiveness of the treatment.
The present invention provides methods and systems for conditioning cerebrospinal fluid (CSF). The methods provide for efficiently removing target compounds from CSF. The systems provide for a multilumen flow path and exchange of a majority volume portion of CSF in the CSF space. The removal and/or delivery of specific compounds can be tailored to the pathology of the specific disease. The removal is targeted and specific, for example, through the use of specific size-exclusion thresholds, antibodies against specific toxins, and other chromatographic techniques, as well as delivery and/or removal of targeted therapeutic agents. The invention finds use as a diagnostic, therapeutic and drug delivery platform for a variety of diseases affecting the CNS by accessing the CSF space. Exemplified disease conditions treatable by the present CSF processing systems and methods include, but are not limited to: Cerebral Vasospasm, Guillain Barre Syndrome, Alzheimer's, Parkinson's, Huntington's, Multiple Sclerosis, Amyotrophic Lateral Sclerosis, Spinal Cord Injury, Traumatic Brain Injury, Stroke, Cancer affecting the brain or spinal cord, Prion disease, Encephalitis from various causes, Meningitis from various causes, diseases secondary to enzymatic or metabolic imbalances, Biological Warfare, etc. For the first time, the present invention offers patients a disease-modifying, disruptive technology treatment platform that addresses the known disease pathogenesis of a number of neurologic conditions to which there are presently limited and ineffective treatment options.
Systems and methods for filtering materials from biologic fluids are discussed. Embodiments may be used to filter cerebrospinal fluid (CSF) from a human or animal subject. The method may include the steps of withdrawing fluid comprising CSF, filtering the volume into permeate and retentate by passing the fluid through a tangential flow filter, and returning the permeate to the subject. During operation of the system, various parameters may be modified, such as flow rate.
A61M 1/00 - Dispositifs de succion ou de pompage à usage médicalDispositifs pour retirer, traiter ou transporter les liquides du corpsSystèmes de drainage
B01D 61/00 - Procédés de séparation utilisant des membranes semi-perméables, p. ex. dialyse, osmose ou ultrafiltrationAppareils, accessoires ou opérations auxiliaires, spécialement adaptés à cet effet
Embodiments may include extracorporeal cooling of cerebrospinal fluid (CSF) or circulating heat transfer fluid within a catheter in the CSF-containing space.
A61B 18/02 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par refroidissement, p. ex. techniques cryogéniques
Systems and methods for treating biologic fluids are disclosed. Some disclosed embodiments may be used to filter cerebrospinal fluid (CSF) from a human or animal subject, heat CSF to a target temperature, cool CSF to a target temperature, apply light treatment to CSF, separate cells via their dielectric properties, apply spiral and/or centrifugal separation, introduce additives to target particles, and/or apply combinations thereof. The method may include the steps of withdrawing fluid comprising CSF, treating the fluid, and returning a portion of the treated fluid to the subject. During operation of the system, various parameters may be modified, such as flow rate.
A61M 1/00 - Dispositifs de succion ou de pompage à usage médicalDispositifs pour retirer, traiter ou transporter les liquides du corpsSystèmes de drainage
A61M 1/34 - Filtration du sang à travers une membrane pour en éliminer une matière, c.-à-d. hémofiltration, diafiltration
A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p. ex. adaptation de la température, irradiation
A61M 27/00 - Appareillage pour drainage des blessures
G01N 33/48 - Matériau biologique, p. ex. sang, urineHémocytomètres
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
53.
SYSTEMS, CATHETERS, AND METHODS FOR TREATING ALONG THE CENTRAL NERVOUS SYSTEM
Systems, catheters, and methods for accessing and treating along the central nervous system are disclosed. An example system may include a system for ameliorating a symptom of bacterial meningitis in a patient. The system may include a catheter assembly having a first lumen with a distal port and a second lumen with a proximal port, said catheter being adapted to be introduced in a CSF space and said ports being spaced axially apart. A pump may be connectable between the first and second lumens to induce a flow of CSF therebetween. A filter component may be connectable between the first and second lumens. The filter component may be configured to remove one or more meningitis causing bacterial pathogen from the CSF, to thereby condition the cerebrospinal fluid.
A portable external device for a mechanical circulation support system includes first and second power sources, e.g. batteries and control electronics for redundant uninterrupted operation of an implantable blood pump. The control and power source module may be configured to accommodate a variety of wearable configurations for patient convenience and comfort.
A61M 60/165 - Pompes ou dispositifs de pompage implantables, c.-à-d. que le sang est pompé à l’intérieur du corps du patient implantables dans ou sur le cœur, ou autour du cœur
A portable external device for a mechanical circulation support system includes first and second power sources, e.g. batteries and control electronics for redundant uninterrupted operation of an implantable blood pump. The control and power source module may be configured for variable form factors to accommodate a variety of wearable configurations for patient convenience and comfort.
A portable external device for a mechanical circulation support system includes first and second power sources, e.g. batteries and control electronics for redundant uninterrupted operation of an implantable blood pump. The control and power source module may be configured to accommodate a variety of wearable configurations for patient convenience and comfort.
