NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
CENTRAL RESEARCH INSTITUTE OF ELECTRIC POWER INDUSTRY (Japon)
Inventeur(s)
Umezawa, Taiki
Nogata, Yasuyuki
Abrégé
Provided is a compound which is synthesized using an amino acid that can be easily procured in the marketplace and used industrially, has activity for inhibiting adhesion of fouling present in sea water, and has low toxicity. The present invention relates to: a dipeptide containing a proline residue which is represented by formula (1), or a tripeptide containing a proline residue and a phenylalanine residue [in the formula, R13-103-10 hydrocarbon group, R2and R31-81-8 hydrocarbon group or the like, and R41-61-6 hydrocarbon group or the like]; and a composition for inhibiting adhesion of marine fouling, which contains this compound.
C07K 5/097 - Tripeptides le premier amino-acide étant hétérocyclique, p. ex. Pro, His, Trp, p. ex. thyrolibérine, mélanostatine
A01N 43/36 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un atome d'azote comme unique hétéro-atome du cycle des cycles à cinq chaînons
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Nagasaki, Yukio
Yasui, Hironobu
Yamada, Sato
Inanami, Osamu
Abrégé
122 includes a dichloroacetyl group.) These copolymers or polymeric micelles which are formed from these copolymers in an aqueous medium have a tumor-specific radiation enhancement effect and enhance the therapeutic effect of radiation therapy on tumors. Consequently, the present invention provides a medical use of these copolymers or polymeric micelles for exerting such an effect.
G11C 11/54 - Mémoires numériques caractérisées par l'utilisation d'éléments d'emmagasinage électriques ou magnétiques particuliersÉléments d'emmagasinage correspondants utilisant des éléments simulateurs de cellules biologiques, p. ex. neurone
G06F 7/58 - Générateurs de nombres aléatoires ou pseudo-aléatoires
G06G 7/60 - Calculateurs analogiques pour des procédés, des systèmes ou des dispositifs spécifiques, p. ex. simulateurs d'êtres vivants, p. ex. leur système nerveux
G11C 16/04 - Mémoires mortes programmables effaçables programmables électriquement utilisant des transistors à seuil variable, p. ex. FAMOS
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Tomita, Kentaro
Abrégé
The present disclosure is directed to a plasma measurement device comprising: a laser light source configured to apply laser light to plasma; and a spectrum measurement unit configured to receive scattered light from the plasma and measure a wavelength spectrum of the scattered light; and an arithmetic unit configured to calculate an electron temperature and an electron density of the plasma, based on the measured wavelength spectrum, wherein the spectrum measurement unit includes a spectroscope having an incidence slit, the incidence slit including: two blades movable in X-direction in an XY-plane perpendicular to a traveling direction of the scattered light; and at least one blade movable in Y-direction perpendicular to X-direction, edges of at least three of the blades forming a slit shape, thereby relaxing the structural constraints for plasma measurement and performing measurement with higher accuracy.
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Furukawa Shinya
Nakaya Yuki
Abrégé
The present invention pertains to a dehydrogenation catalyst for producing propylene by a dehydrogenation reaction of propane, said catalyst comprising MFI type zeolite, elemental platinum, and elemental M, wherein: the molar ratio (Si/Al) of silicon to elemental aluminum of the MFI type zeolite is 50 or more; the elemental M is at least one element selected from the group consisting of elemental germanium, elemental copper, elemental indium, elemental iron, elemental ruthenium, and elemental rhenium; and the elemental platinum and the elemental M are located in a channel of the MFI type zeolite.
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Yunoki, Shunji
Kondo, Eiji
Hiraoka, Yosuke
Mandai, Yoshinobu
Kishimoto, Masanori
Abrégé
This collagen yarn contains collagen nanofibrils, and has a diameter of 10-50 μm and a total length of 2 × 105times or more greater than the diameter, wherein the collagen nanofibrils exhibit high alignment properties along the longitudinal direction of the collagen yarn, the high alignment properties are indicated by a fact that the refractive index difference determined by a birefringence measurement performed on a hydrated collagen yarn is 4.3 × 10-4 or more, and the hydrated collagen yarn is obtained by immersing the collagen yarn in a neutral phosphate buffer solution.
National University Corporation Hokkaido University (Japon)
Inventeur(s)
Ishikawa, Tsutomu
Fujiwara, Naoki
Sato, Takanori
Saitoh, Kunimasa
Abrégé
A method of manufacturing an optical filter is a method of manufacturing an optical filter including two or more waveguides having four or more sections in which a number of modes of light propagating through the four or more sections is two or more. The method includes designing lengths of the four or more sections, and forming the two or more waveguides based on the lengths of the four or more sections. The designing includes designing the lengths of the four or more sections based on differentiation of propagation constants of the sections with respect to a temperature and widths of the sections.
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Ikebe Masayuki
Nozu Ayato
Abrégé
Provided are a pressure sensor and the like that are capable of accurately detecting, as a surface, a pressure applied to an object from the outside. The present invention is provided with: a plurality of sensor pixels PX that are arranged in a surface formation, the sensor pixels PX being each equipped with a membranous pressure-sensitive film 2 having a resistance value that varies by the front surface of the pressure-sensitive film 2 being pressed, and a first electrode layer 4 and a second electrode layer 6 laminated only on the back surface of the pressure-sensitive film 2; and a drive circuit that drives each of the sensor pixels PX, the drive circuit detecting, according to variations in the resistance values caused by pressing the plurality of sensor pixels PX, the pressure of the pressing for each of the sensor pixels PX.
G01L 5/00 - Appareils ou procédés pour la mesure des forces, du travail, de la puissance mécanique ou du couple, spécialement adaptés à des fins spécifiques
9.
EFFICIENT CHEMO-ENZYMATIC SYNTHESIS METHOD FOR CYCLIC PEPTIDE
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Wakimoto, Toshiyuki
Matsuda, Kenichi
Kobayashi, Masakazu
Abrégé
A method for producing a cyclic peptide, comprising using a penicillin-binding protein-type thioesterase (PBP-type TE) or a tyrocidine synthase TycC thioesterase domain (TycC-TE) as a catalyst, wherein a diol as a leaving group is attached to a carboxyl group of a C-terminal residue of a substrate; and a method for producing a peptide serving as the substrate using a solid phase carrying a diol.
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Kaneko, Junichi
Yamaishi, Naoya
Higuchi, Mikio
Abrégé
The present invention enables easy acquisition of an excellent electrical contact while using electrodes made of a metal other than thallium. A radiation detector 1 is provided with: a crystal 2 containing thallium bromide as the main component; and electrodes 3 and 4 which are in contact with the crystal 2 so as to sandwich the crystal 2 therebetween in an X direction and which are made of a metal other than thallium. Portions of the crystal 2 in contact with the electrodes 3 and 4 are doped with at least one of strontium, lead, thallium, and bromine.
POSITIVE ELECTRODE BODY OF SOLID ELECTROLYTIC CAPACITOR, SOLID ELECTROLYTIC CAPACITOR, METHOD FOR MANUFACTURING POSITIVE ELECTRODE BODY OF SOLID ELECTROLYTIC CAPACITOR, AND METHOD FOR MANUFACTURING SOLID ELECTROLYTIC CAPACITOR
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Habazaki Hiroki
David Alberto Quintero Giraldo
Nagahara Kazuhiro
Tanaka Atsushi
Koseki Kazuya
Nakayama Yuki
Abrégé
Provided are: a positive electrode body of a solid electrolytic capacitor that has a high withstand voltage and a low leakage current; a solid electrolytic capacitor; a method for manufacturing the positive electrode body of the solid electrolytic capacitor; and a method for manufacturing the solid electrolytic capacitor. This positive electrode body comprises: a valve action metal substrate; and a dielectric oxide film on the valve action metal substrate. The dielectric oxide film comprises: a void layer on a surface layer side of the dielectric oxide film; and a void repair layer on the side of the dielectric oxide film that interfaces with the valve action metal substrate. This positive electrode body is formed by first chemical conversion processing, void introduction processing, and second chemical conversion processing. In the first chemical conversion processing, a prescribed chemical conversion voltage is applied to the valve action metal substrate. In the void introduction processing, the positive electrode body is immersed in one or more of an acidic solution, an alkaline solution, and pure water. In the second chemical conversion processing, a chemical conversion voltage lower than that of the first chemical conversion treatment is applied.
H01G 9/00 - Condensateurs électrolytiques, redresseurs électrolytiques, détecteurs électrolytiques, dispositifs de commutation électrolytiques, dispositifs électrolytiques photosensibles ou sensibles à la températureProcédés pour leur fabrication
12.
MULTIPLEXER/DEMULTIPLEXER, METHOD OF MANUFACTURING THE SAME, DESIGNING DEVICE, NON-TRANSITORY COMPUTER-READABLE RECORDING MEDIUM, AND DEMULTIPLEXER
National University Corporation Hokkaido University (Japon)
Inventeur(s)
Mitarai, Takuya
Fujiwara, Naoki
Fujisawa, Takeshi
Abrégé
A method according to the present disclosure is a method of manufacturing a multiplexer/demultiplexer including a substrate, a first port for inputting light, and a second port for outputting light, the first port and the second port being provided in the substrate. The method includes designing positions of a plurality of holes such that three adjacent holes among the plurality of holes are arranged in a triangle lattice, and forming the plurality of holes in a surface of the substrate.
G02B 6/293 - Moyens de couplage optique ayant des bus de données, c.-à-d. plusieurs guides d'ondes interconnectés et assurant un système bidirectionnel par nature en mélangeant et divisant les signaux avec des moyens de sélection de la longueur d'onde
G02B 27/00 - Systèmes ou appareils optiques non prévus dans aucun des groupes ,
13.
PHARMACEUTICAL COMPOSITION FOR TREATING PERIPHERAL NERVE INJURY
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Kadoya, Ken
Yamamoto, Yasuhiro
Abrégé
A pharmaceutical composition for treating peripheral nerve injury, includes a substance that inhibits the formation of neutrophil extracellular traps (NETs) outside the parenchyma of injured peripheral nerves, for example, a substance that inhibits the accumulation of neutrophils in injured peripheral nerves, a substance that suppresses the expression or inhibits the function of macrophage migration inhibitory factor (MIF), etc. Further provided is a method for evaluating the peripheral nerve regeneration-promoting activity of a test substance using, as an indicator, the activity to inhibit the formation of NETs outside the parenchyma of injured peripheral nerves, for example, the activity to inhibit the accumulation of neutrophils in injured peripheral nerves, the activity to suppress the expression of MIF or the activity to inhibit the function thereof, etc.
C07K 16/24 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des cytokines, des lymphokines ou des interférons
A61K 31/166 - Amides, p. ex. acides hydroxamiques ayant des cycles aromatiques, p. ex. colchicine, aténolol, progabide ayant l'atome de carbone d'un groupe carboxamide lié directement au cycle aromatique, p. ex. procaïnamide, procarbazine, métoclopramide, labétalol
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
C12N 15/115 - Aptamères, c.-à-d. acides nucléiques liant spécifiquement une molécule cible avec une haute affinité sans s'y hybrider
14.
CATHODE ELECTRODE CATALYST FOR AMMONIA ELECTROSYNTHESIS, AND AMMONIA ELECTROSYNTHESIS DEVICE
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Masubuchi, Yuji
Kusano, Haruka
Abrégé
Provided is a cathode electrode catalyst for ammonia electrosynthesis that contains a perovskite-type metal oxynitride. The perovskite-type metal oxynitride includes, as main metal elements: A, which is at least one element selected from the group consisting of Ba, Sr, and Ca and which contains 50 mol% or more of Ba; and Mo or B, which is at least one element selected from the group consisting of Ta, Nb, and W. The perovskite-type metal oxynitride satisfies a prescribed formula.
National University Corporation Hokkaido University (Japon)
Inventeur(s)
Konnai, Satoru
Ohashi, Kazuhiko
Murata, Shiro
Okagawa, Tomohiro
Nishimori, Asami
Maekawa, Naoya
Suzuki, Yasuhiko
Nakajima, Chie
Abrégé
The present disclosure provides an anti-PD-L1 antibody capable of repeated administration even to animals other than rat. The present disclosure further provides a novel therapeutic strategy using an inhibitor targeting PD-1/PD-L1. A pharmaceutical composition which comprises a COX-2 inhibitor and is administered before, after or simultaneously with the administration of an inhibitor targeting PD-1/PD-L1. A potentiator for the immunostimulatory effect of an inhibitor targeting PD-1/PD-L1, which comprises a COX-2 inhibitor. The present disclosure also provides an anti-PD-1 antibody capable of repeated administration even to animals other than rat. An anti-PD-1 antibody comprising (a) a light chain comprising a light chain variable region containing CDR1 having the amino acid sequence of QSLEYSDGYTY (SEQ ID NO: 164), CDR2 having the amino acid sequence of GVS and CDR3 having the amino acid sequence of FQATHDPDT (SEQ ID NO: 165) and the light chain constant region of an antibody of an animal other than rat; and (b) a heavy chain comprising a heavy chain variable region containing CDR1 having the amino acid sequence of GFSLTSYY (SEQ ID NO: 166), CDR2 having the amino acid sequence of IRSGGST (SEQ ID NO: 167) and CDR3 having the amino acid sequence of ARTSSGYEGGFDY (SEQ ID NO: 168) and the heavy chain constant region of an antibody of an animal other than rat. A pharmaceutical composition comprising the above-described anti-PD-1 antibody as an active ingredient. A method for preparing the anti-PD-1 antibody is also provided.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
DAICEL CORPORATION (Japon)
Inventeur(s)
Ishihara, Hajime
Wada, Takudo
Sasaki, Keiji
Makino, Yuto
Abrégé
A particle discrimination mechanism includes: a channel in which a plurality of first nanoparticles each including an absorber having a predetermined absorption level and a plurality of second nanoparticles each of which does not include the absorber having the predetermined absorption level exist, the channel including a first input section and a second input section; a laser that outputs first light, which is absorbed by the absorber having the predetermined absorption level, in a direction from the first input section toward the second input section; a laser that outputs second light, which is not absorbed by the absorber having the predetermined absorption level but is scattered or absorbed by the second nanoparticles, in a direction from the second input section toward the first input section.
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Takayanagi, Taisuke
Hirayama, Shusuke
Miyazaki, Koichi
Yamada, Takahiro
Aoyama, Hidefumi
Hashimoto, Takayuki
Katoh, Norio
Taguchi, Hiroshi
Yasuda, Koichi
Nishioka, Kentaro
Kobashi, Keiji
Matsuura, Taeko
Takao, Seishin
Miyamoto, Naoki
Abrégé
Provided is a treatment support system capable of easily determining a radiation treatment device desirable for a patient. An arithmetic processing device 101 predicts a treatment effect index for each treatment modality of a radiation treatment device 202 by using a region of interest which corresponds to a part related to the irradiation of a patient with radioactive ray in a three-dimensional fluoroscopic image showing the patient, and also using parameter information which indicates a value of a parameter for the prediction of a treatment effect index for evaluating the effect of a radiation treatment for each treatment modality of the radiation treatment device 202 for performing the radiation treatment.
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Nagata, Harunori
Wakita, Masashi
Kamps, Landon Thomas
Takada, Yusuke
Iwanaga, Kodai
Ono, Genta
Abrégé
The invention provides a method for combusting of a hybrid rocket fuel, comprising supplying aqueous solution of hydrogen peroxide to a combustion chamber provided with a solid fuel, wherein a concentration of hydrogen peroxide in the aqueous solution of hydrogen peroxide is less than 65% by weight, and the method for combusting comprises at least one of: (i) supplying oxygen and the aqueous solution of hydrogen peroxide to the combustion chamber, and (ii) heating the aqueous solution of hydrogen peroxide before supplying the aqueous solution of hydrogen peroxide to the combustion chamber.
F02K 9/72 - Moteurs-fusées, c.-à-d. ensembles fonctionnels portant à la fois le combustible et son oxydantLeur commande utilisant des propergols liquides et solides, c.-à-d. ensembles fonctionnels de moteurs-fusées hybrides
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Harashima, Hideyoshi
Onuma, Haruno
Sato, Yusuke
Abrégé
The present invention provides lipid nanoparticles each containing a pH-sensitive cationic lipid represented by formula (I) [wherein a represents an integer of 3 to 5; b represents 0 or 1; R1 and R2 each independently represent a group represented by general formula (A) (wherein R11 and R12 each independently represent a linear or branched C1-15 alkyl group; c represents an integer of 1 to 7: and e represents an integer of 4 to 12); and X represents a group represented by general formula (B) (wherein d represents an integer of 0 to 3; and R3 and R4 each independently represent a C1-4 alkyl group or a C2-4 alkenyl group, in which R3 and R4 may be bonded to each other to form a 5- to 7-membered nonaromatic hetero ring) or a 5- to 7-membered nonaromatic hetero ring group]. (R1)(R2)C(OH)-(CH2)a-(O-CO)b-X (I) (R11)(R12)HC-(CH2)c-(CO-O)-(CH2)e-(A) -(CH2)d-N(R3)(R4) (B)
A61K 31/7088 - Composés ayant au moins trois nucléosides ou nucléotides
A61K 31/7105 - Acides ribonucléiques naturels, c.-à-d. contenant uniquement des riboses liés à l'adénine, la guanine, la cytosine ou l'uracile et ayant des liaisons 3'-5' phosphodiester
A61K 31/713 - Acides nucléiques ou oligonucléotides à structure en double-hélice
A61K 47/18 - AminesAmidesUréesComposés d’ammonium quaternaireAcides aminésOligopeptides ayant jusqu’à cinq acides aminés
A61P 1/16 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des troubles de la vésicule biliaire ou du foie, p. ex. protecteurs hépatiques, cholagogues, cholélitholytiques
C07C 219/06 - Composés contenant des groupes amino et hydroxy estérifiés liés au même squelette carboné ayant des groupes hydroxy estérifiés et des groupes amino liés à des atomes de carbone acycliques du même squelette carboné le squelette carboné étant acyclique et saturé les groupes hydroxy étant estérifiés par des acides carboxyliques ayant les groupes carboxyle estérifiants liés à des atomes d'hydrogène ou à des atomes de carbone acycliques d'un squelette carboné acyclique saturé
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
C12N 15/88 - Introduction de matériel génétique étranger utilisant des procédés non prévus ailleurs, p. ex. co-transformation utilisant la micro-encapsulation, p. ex. utilisant des vésicules liposomiques
20.
OPTICAL FILTER, METHOD OF MANUFACTURING AN OPTICAL FILTER, METHOD OF DESIGNING, DESIGN APPARATUS, AND NON-TRANSITORY COMPUTER-READABLE RECORDING MEDIUM
National University Corporation Hokkaido University (Japon)
Inventeur(s)
Ishikawa, Tsutomu
Fujiwara, Naoki
Fujisawa, Takeshi
Sato, Takanori
Saitoh, Kunimasa
Abrégé
It is an object to provide an optical filter, a method of manufacturing an optical filter, a method of designing, a design apparatus, and a program for designing non-transitory computer-readable recording medium which can suppress both the temperature dependency and the waveguide length. An optical filter includes three or more waveguides, and a plurality of sections provided in the three or more waveguides, respectively. Modes of light propagating through the sections of the three or more waveguides are different from each other.
G02B 6/293 - Moyens de couplage optique ayant des bus de données, c.-à-d. plusieurs guides d'ondes interconnectés et assurant un système bidirectionnel par nature en mélangeant et divisant les signaux avec des moyens de sélection de la longueur d'onde
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Mizuno Hitoshi
Iwasaki Norimasa
Onodera Tomohiro
Iwasaki Koji
Abrégé
Provided is a curette having the function of making it possible to easily confirm the orientation of an affected site surface in a body cavity. This curette comprises: a shaft part 2 that extends in a linear rod shape; and a head part 3 that is provided at the tip end of the shaft part 2. The shaft part 2 is provided with a posture recognition part 5 that, if the head part 3 is at a surface, can recognize the vertical direction n1 of said surface and, if the head part 3 is not at a surface, can recognize the direction in which the tip of the head part is pointing.
A61B 17/56 - Instruments ou procédés chirurgicaux pour le traitement des os ou des articulationsDispositifs spécialement adaptés à cet effet
22.
METHOD FOR GENERATING SPECTRAL DATA PERTAINING TO MICROPARTICLE SAMPLE, METHOD FOR ANALYZING MICROPARTICLES, METHOD FOR DISTINGUISHING MICROPARTICLES, METHOD FOR ASSESSING WHETHER CANCER-CELL-DERIVED EXOSOMES ARE PRESENT, SUBSTRATE FOR MEASURING SPECTRUM OF MICROPARTICLES, DEVICE FOR MEASURING SPECTRUM OF MICROPARTICLES, AND APPARATUS FOR MEASURING SPECTRUM OF MICROPARTICLES
National University Corporation Hokkaido University (Japon)
Osaka University (Japon)
Inventeur(s)
Ryuzaki, Sou
Matsuda, Rintaro
Taniguchi, Masateru
Komoto, Yuki
Abrégé
A method for generating spectral data according to the present invention involves generating spectral data pertaining to a microparticle sample that includes at least one microparticle, wherein: the method includes a step for acquiring a measurement spectrum from microparticles disposed within a through-hole in a substrate; the through-hole has an inclined structure in which the width continuously decreases from one surface of the substrate toward the other surface thereof; at least part of the inner surface of the through-hole is configured from a metal that exhibits plasmon resonance; and in the step for acquiring the measurement spectrum, the measurement spectrum is acquired while the interior of the through-hole is irradiated with light.
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Maenaka, Katsumi
Matsuda, Akira
Sawa, Hirofumi
Orba, Yasuko
Sasaki, Michihito
Uemura, Kentaro
Abrégé
The present invention provides an antiviral agent formed from a compound represented by general formula (A-1) or (A-2) shown below [wherein in the formulas, R1 represents O, S, Se or =N—OR11; R2 represents O, S, Se or ═N—OR11; R3 represents —O—R12, —S—R13 or a guanidino group; R11 represents H, an alkyl group or an aryl group; R12 and R13 each independently represent an alkyl group or an aryl group; R4 represents H, —CO—R14 or —O—P(OH)(═O)—O—R15; R14 and R15 each independently represent an alkyl group or an aryl group; R5 and R6 each independently represent H or —CO—R16; and R16 represents an alkyl group of 1 to 6 carbon atoms or an aryl group], a salt of the compound, or a solvate of the compound or salt.
A61K 31/7068 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p. ex. nucléosides, nucléotides contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle contenant des pyrimidines condensées ou non-condensées ayant des groupes oxo liés directement au cycle pyrimidine, p. ex. cytidine, acide cytidylique
A61P 31/14 - Antiviraux pour le traitement des virus ARN
C07H 19/067 - Radicaux pyrimidine avec un ribosyle comme radical saccharide
24.
CEMENT COMPOSITION FOR FIXING CARBON DIOXIDE, CEMENT HARDENED BODY FOR FIXING CARBON DIOXIDE, AND METHOD FOR FIXING CARBON DIOXIDE
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Saito Ryosuke
Yoda Yuya
Yano Keiichi
Tsujino Masato
Nishida Akira
Kitagaki Ryoma
Elaknes Yogarajah
Senboku Hisanori
Sakairi Masatoshi
Fushimi Koji
Abrégé
This cement composition for fixing carbon dioxide contains a cement composition and a carbon dioxide absorption liquid containing a carbon dioxide absorbent. This cement hardened body for fixing carbon dioxide includes a cement hardened body and a carbonate carried on the cement hardened body. This method for fixing carbon dioxide has: a step for kneading a carbon dioxide absorption liquid containing a carbon dioxide absorbent into a cement composition; a step for hardening the cement composition containing the carbon dioxide absorbent to obtain a cement hardened body for fixing carbon dioxide; and a step for bringing the atmosphere into contact with the cement hardened body for fixing carbon dioxide, and fixing the carbon dioxide contained in the atmosphere to the cement hardened body for fixing carbon dioxide.
C04B 28/02 - Compositions pour mortiers, béton ou pierre artificielle, contenant des liants inorganiques ou contenant le produit de réaction d'un liant inorganique et d'un liant organique, p. ex. contenant des ciments de polycarboxylates contenant des ciments hydrauliques autres que ceux de sulfate de calcium
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
TOHOKU UNIVERSITY (Japon)
OCHANOMIZU UNIVERSITY (Japon)
Inventeur(s)
Satoh Toshifumi
Isono Takuya
Li Feng
Ebe Minami
Suzuki Kazushige
Ibe Kotaro
Ebii Yamato
Deguchi Tetsuo
Jinnai Hiroshi
Abrégé
Disclosed is a polymer material that comprises: a cyclic polymer which has one or more annular parts; and a crosslinked polymer which has a plurality of linear parts, and in which the plurality of linear parts are bonded to each other at crosslinking points so as to form a crosslinked body. At least some of the cyclic polymers in the polymer material each have an annular part that is penetrated by a linear part of the crosslinked polymer. The ratio of the amount of the cyclic polymer to the amount of the crosslinked polymer may be 15% by mass or more.
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Ichikawa Satoshi
Katsuyama Akira
Kaguchi Rintaro
Abrégé
Provided are: an amino acid compound, for scanning, capable of rapidly synthesizing a modified peptide and assessing the activity of the modified peptide; a modified peptide for scanning; a kit for scanning; and a scanning method for active sites in a peptide. This amino acid compound for scanning is to be used for scanning active sites in a peptide when being introduced so as to substitute a portion of amino acids in a peptide, and is a compound having, in a portion of the structure thereof, a 1,2-amino alcohol or is a substitution product of the same. The present invention also pertains to a modified peptide for scanning, a kit for scanning, and a scanning method for active sites in a peptide.
C07C 271/34 - Esters des acides carbamiques ayant des atomes d'oxygène de groupes carbamate liés à des atomes de carbone de cycles autres que des cycles aromatiques à six chaînons avec les atomes d'azote des groupes carbamate liés à des atomes d'hydrogène ou à des atomes de carbone acycliques
A61K 38/08 - Peptides ayant de 5 à 11 amino-acides
C07C 271/22 - Esters des acides carbamiques ayant des atomes d'oxygène de groupes carbamate liés à des atomes de carbone acycliques avec les atomes d'azote des groupes carbamate liés à des atomes d'hydrogène ou à des atomes de carbone acycliques à des atomes de carbone de radicaux hydrocarbonés substitués par des groupes carboxyle
C07K 1/04 - Procédés généraux de préparation de peptides sur des supports
27.
STRUCTURAL COLOR MEMBER AND METHOD FOR MANUFACTURING THE SAME
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Kikuchi Tatsuya
Ashizawa Raiko
Nakajima Daiki
Abrégé
This structural color member (1) has a base material (2) and an oxide film (3) that is formed of a metal oxide and that covers the base material (2). The oxide film (3) includes a porous layer (31) that includes a plurality of pores (311) and that is disposed on the base material (2), and a dense layer (32) that does not include the pores (311) and that is laminated on the porous layer (31). When the thickness of the oxide film (3) is measured at various positions, the thickness of the oxide film (3) at each measurement position is within the ranges of 150 nm to 1000 nm and 0.75 times to 1.25 times the average value of the thickness of the oxide film (3).
C23C 28/00 - Revêtement pour obtenir au moins deux couches superposées, soit par des procédés non prévus dans un seul des groupes principaux , soit par des combinaisons de procédés prévus dans les sous-classes et
National Institute of Information and Communications Technology (Japon)
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
The University of Tokyo (Japon)
Inventeur(s)
Yoshino, Ken-Ichiro
Fujiwara, Mikio
Tomita, Akihisa
Koashi, Masato
Takeoka, Masahiro
Abrégé
An object is to prevent eavesdropping in quantum key distribution. A synchronization signal reception device receives a synchronization signal that is an optical signal for defining a timing at which a quantum signal is detected, and outputs a reference signal corresponding to the synchronization signal. A clock signal generation unit generates a clock signal in response to the reference signal. A photon detection device detects a photon of the quantum signal in response to the clock signal. A timing of the clock signal randomly changes within a predetermined range.
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Gong Jian Ping
Fan Hailong
Liao Hongguang
Abrégé
This adsorbent contains a copolymer of a cationic functional group-containing monomer or an anionic functional group-containing monomer and an aromatic group-containing monomer, the copolymer having a specific structure in at least a part thereof.
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Taoda, Yoshiyuki
Uehara, Shota
Sako, Yuseke
Hirai, Keiichiro
Abrégé
The present invention provides a compound exhibiting coronavirus 3CL protease inhibitory activity or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same.
The present invention provides a compound exhibiting coronavirus 3CL protease inhibitory activity or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same.
Provided is a compound represented by Formula (I):
The present invention provides a compound exhibiting coronavirus 3CL protease inhibitory activity or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same.
Provided is a compound represented by Formula (I):
wherein carbon atom a and carbon atom b are each a carbon atom constituting ring A, the ring A is substituted aromatic carbocycle or the like, R1 is substituted or unsubstituted aromatic heterocyclyl or the like, R2 is substituted or unsubstituted 6-membered aromatic carbocyclyl or the like, m is 1 or the like, R5as are each independently a hydrogen atom or the like, R5bs are each independently a hydrogen atom or the like, n is 1 or the like, R4a is a hydrogen atom or the like, and R4a is a hydrogen atom or the like. Alternatively, provided is a pharmaceutically acceptable salt of the compound.
A61K 31/517 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des systèmes carbocycliques, p. ex. quinazoline, périmidine
A61K 31/519 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
A61K 31/5386 - 1,4-Oxazines, p. ex. morpholine condensées en spiro ou formant une partie de systèmes cycliques pontés
A61P 31/14 - Antiviraux pour le traitement des virus ARN
C07D 401/06 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne carbonée contenant uniquement des atomes de carbone aliphatiques
C07D 403/06 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne carbonée ne contenant que des atomes de carbone aliphatiques
C07D 491/048 - Systèmes condensés en ortho avec un seul atome d'oxygène comme hétéro-atome du cycle contenant de l'oxygène le cycle contenant de l'oxygène étant à cinq chaînons
C07D 519/00 - Composés hétérocycliques contenant plusieurs systèmes de plusieurs hétérocycles déterminants condensés entre eux ou condensés avec un système carbocyclique commun non prévus dans les groupes ou
31.
PH-SENSITIVE CATIONIC LIPID AND LIPID NANOPARTICLES
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Sato Yusuke
Harashima Hideyoshi
Ito Rina
Suzuki Yuichi
Abrégé
Provided are: a pH-sensitive cationic lipid which can be more easily synthesized through a small number of steps without requiring any organometal reaction or use of any relatively expensive starting materials; and lipid nanoparticles including the lipid. Disclosed is a pH-sensitive cationic lipid comprising a compound represented by general formula (I) or (I'). R1, Z2, s, Z1, and X are as defined in the description.
C07D 211/62 - Atomes de carbone comportant trois liaisons à des hétéro-atomes, avec au plus une liaison à un halogène, p. ex. radicaux ester ou nitrile liés en position 4
A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique
A61K 47/22 - Composés hétérocycliques, p. ex. acide ascorbique, tocophérol ou pyrrolidones
A61K 47/28 - Stéroïdes, p. ex. cholestérol, acides biliaires ou acide glycyrrhétinique
A61K 47/34 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyesters, acides polyaminés, polysiloxanes, polyphosphazines, copolymères de polyalkylène glycol ou de poloxamères
C07D 295/15 - Composés hétérocycliques contenant des cycles polyméthylène imine d'au moins cinq chaînons, des cycles aza-3 bicyclo [3.2.2] nonane, piperazine, morpholine ou thiomorpholine, ne comportant que des atomes d'hydrogène liés directement aux atomes de carbone du cycle avec des radicaux hydrocarbonés substitués liés aux atomes d'azote du cycle substitués par des atomes de carbone comportant trois liaisons à des hétéro-atomes avec au plus une liaison à un halogène, p. ex. radicaux ester ou nitrile avec les atomes d'azote du cycle et les atomes de carbone comportant trois liaisons à des hétéro-atomes liés à la même chaîne carbonée, qui n'est pas interrompue par des carbocycles à une chaîne acyclique saturée
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Hiruma, Atsuyuki
Ogasawara, Satoshi
Abrégé
A common-mode voltage canceller cancels a common-mode voltage that is generated in accompaniment with operation of an inverter that converts direct-current power to alternating-current power. The common-mode voltage canceller includes a common-mode transformer that generates a cancellation voltage that has a polarity reverse to the common-mode voltage. The common-mode transformer is disposed on a direct-current power line that supplies the direct-current power to the inverter.
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
THE SCHOOL CORPORATION KANSAI UNIVERSITY (Japon)
Inventeur(s)
Okamoto, Mamoru
Takemoto, Takashi
Uchigaito, Hiroshi
Krasienapibal, Thantip Sirinabhigupta
Nakamura, Atsuyoshi
Kobayashi, Masato
Mizuno, Yuta
Teramoto, Hiroshi
Abrégé
It is provided an area design proposal system for proposing equipment placement and configuration of a regional energy system comprising: a long-term operation optimization module configured to output an optimum solution for the equipment placement and configuration through use of a long-term operation algorithm with input of parameters including energy equipment information, vehicle equipment information, an energy equipment introduction cost, a vehicle introduction cost, and an initial cost upper limit amount; and a short-term operation optimization module configured to calculate short-term operation evaluation results, which are evaluation results of the equipment placement and configuration, through use of a short-term operation algorithm with input of the output from the long-term operation optimization module and short-term environmental fluctuation factors, and wherein the long-term operation optimization module is configured to optimize the equipment placement and configuration with input of the short-term operation evaluation results.
G06F 30/18 - Conception de réseaux, p. ex. conception basée sur les aspects topologiques ou d’interconnexion des systèmes d’approvisionnement en eau, électricité ou gaz, de tuyauterie, de chauffage, ventilation et climatisation [CVC], ou de systèmes de câblage
34.
OPTICAL MODULATION DEVICE AND LIGHT FOCUSING DEVICE
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY (République de Corée)
Inventeur(s)
Shibukawa, Atsushi
Sudo, Yuki
Mooseok, Jang
Abrégé
Provided is a spatial light modulation device which can be driven at a frame rate higher than that of a two-dimensional light modulator. A spatial light modulation device (10) includes a two-dimensional light modulator (11) including a cell group (C) in which cells are arranged in a matrix manner, and a scanning optical system (cylindrical lens 14, scanning mirror 16, objective lens 17). The scanning optical system repeatedly carries out a first conversion step (S11) of converting a two-dimensional beam (L21) into a one-dimensional beam (L11), a modulation step (S12) of generating a spatially modulated one-dimensional beam (L12), and a second conversion step (S13) of converting the modulated one-dimensional beam (L12) into a two-dimensional beam (L22), while changing a column of the cell group (C) which the one-dimensional beam (L11) is caused to enter in the modulation step (S12).
G02B 26/08 - Dispositifs ou dispositions optiques pour la commande de la lumière utilisant des éléments optiques mobiles ou déformables pour commander la direction de la lumière
35.
METHOD FOR PRODUCING FINE PARTICLES, FINE PARTICLES, FINE PARTICLE DISPERSION, AND COMPOSITE PARTICLES
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Takano Yuta
Abrégé
This method for producing fine particles involves hydrolysis in a reaction solution that includes intermediate particles, a hydrolytic enzyme, and a solvent including water, wherein: the intermediate particles have two or more hydrophobic core parts and a linking group linking the two or more core parts; the linking group has a hydrolyzable group; and the hydrolyzable group is hydrolyzed to form fine particles including one or more core parts and having an average particle diameter smaller than the average particle diameter of the intermediate particles.
C12P 1/00 - Préparation de composés ou de compositions, non prévue dans les groupes , utilisant des micro-organismes ou des enzymesProcédés généraux de préparation de composés ou de compositions utilisant des micro-organismes ou des enzymes
36.
PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING REFRACTORY BONE DEFECTS
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
KIDSWELL BIO CORPORATION (Japon)
Inventeur(s)
Takahata Masahiko
Kobayashi Hideyuki
Fujita Ryo
Murakami Toshifumi
Mitani Yasuyuki
Fukuda Noritaka
Abrégé
The present invention pertains to a pharmaceutical composition for preventing or treating refractory bone defects, the pharmaceutical composition comprising: human dental pulp stem cells; and a porous scaffold material having bone-inducing ability. Preferably, the human dental pulp stem cells are cultured together with the scaffold material, and are applied to a bone defect part to assist in the regeneration of bone tissue containing cancellous bone.
A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
A61K 47/34 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyesters, acides polyaminés, polysiloxanes, polyphosphazines, copolymères de polyalkylène glycol ou de poloxamères
A61K 47/42 - ProtéinesPolypeptidesLeurs produits de dégradationLeurs dérivés p. ex. albumine, gélatine ou zéine
A61K 47/44 - Huiles, graisses ou cires couvertes par plus d’un des groupes Huiles, graisses ou cires naturelles ou naturelles modifiées, p. ex. huile de ricin, huile de ricin polyéthoxylée, cire de lignite, lignite, gomme-laque, colophane, cire d’abeille ou lanoline
A61L 27/12 - Matériaux contenant du phosphore, p. ex. apatite
A61L 27/18 - Matériaux macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone
A61L 27/36 - Matériaux pour prothèses ou pour revêtement de prothèses contenant des constituants de constitution indéterminée ou leurs produits réactionnels
A61L 27/40 - Matériaux composites, c.-à-d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent
A61L 27/44 - Matériaux composites, c.-à-d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice macromoléculaire
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Kondo Toyohiro
Soda Hiroki
Ueda Naoharu
Nawa Masamichi
Kato Norihiko
Noda Itsuki
Iida Takumi
Abrégé
This automatic conveyance system is provided with a plurality of conveyance devices and a management device that manages the plurality of conveyance devices. The management device is capable of executing: a task assignment process for assigning a task to each of the conveyance devices; and a task optimization process for switching conveyance tasks when a conveyance cost is calculated for the case in which assigned conveyance tasks are switched between two of the conveyance devices different from each other and if the calculated conveyance cost is less than a conveyance cost at the time of the task assignment process, or when a conveyance cost is calculated for the case in which the assigned conveyance tasks and unassigned conveyance tasks are switched and if the calculated conveyance cost is less than a conveyance cost in which the unassigned conveyance tasks are assigned to any of the conveyance devices. The management device executes the task optimization process while the conveyance devices processes the tasks assigned by the task assignment process.
B65G 1/00 - Emmagasinage d'objets, individuellement ou avec une certaine ordonnance, dans des entrepôts ou des magasins
B65G 1/137 - Dispositifs d'emmagasinage mécaniques avec des aménagements ou des moyens de commande automatique pour choisir les objets qui doivent être enlevés
38.
COMBINATION VACCINE FOR PREVENTION OF INFLUENZA AND CORONAVIRUS INFECTIONS
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
KM BIOLOGICS CO., LTD. (Japon)
Inventeur(s)
Shingai Masashi
Kida Hiroshi
Ogasawara Kazumasa
Endo Masafumi
Okumura Minako
Nagasato Toshiaki
Abrégé
Disclosed is a combination vaccine for the prevention of influenza and new coronavirus infections. As a combination vaccine for vaccination against influenza and new coronaviruses, an inactivated whole virus particle vaccine, in which viral particles of an influenza virus and viral particles of a new coronavirus are inactivated respectively, is prepared. This vaccine induces neutralizing antibodies against the respective viruses without affecting vaccine effects so that protective effects against the attacks of the respective viruses are obtained. Further, the combination vaccine having this combination well induces neutralizing antibodies and exhibits protective effects against the attacks of the viruses even without adding an adjuvant.
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
SUMITOMO PHARMA CO., LTD. (Japon)
Inventeur(s)
Seino Ken-Ichro
Kamatani Tomoki
Abrégé
The present invention provides a composition for inducing immune tolerance, the composition containing: pluripotent stem cells that have the ability to form teratoma cells; or teratoma cells derived from the pluripotent stem cells. The present invention also provides a method for inducing immune tolerance in a mammalian individual, the method including administering an effective amount of the pluripotent stem cells or the teratoma cells to a mammal individual for which immune tolerance is desired. By inducing immune tolerance in a mammalian individual by an immune-tolerance-inducing composition and an immune tolerance inducer, autoimmune diseases can be treated and allogeneic transplantation can be performed under a condition in which a reduced amount of an immunosuppressant is used compared to the amount conventionally used, or under a condition in which no immunosuppressant is used.
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
KONAN GAKUEN (Japon)
Inventeur(s)
Iwasaki, Norimasa
Onodera, Tomohiro
Yamaguchi, Jun
Nagahama, Koji
Saito, Mitsuru
Abrégé
It is desirable to provide a novel biomaterial and the like for tendon repair. Provided is a biomaterial for tendon repair containing a hydrogel formed by means of a cross-linking reaction between a reactive group A and a reactive group B, wherein the hydrogel contains a water-soluble polymer having the reactive group A, and mesenchymal stem cells having the reactive group B.
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
CELLSPECT CO., LTD. (Japon)
Inventeur(s)
Satoh Hisashi
Nakaya Yuki
Nakajima Meri
Handa Hisazumi
Sanari Kota
Hirano Reiko
Doi Kazuhiko
Hojo Wataru
Iwabuchi Takuya
Sakai Hironori
Abrégé
Provided is a microbial nucleic acid detection method, etc., that permits fast, easy, and highly accurate measurement of the concentration of a target nucleic acid and can also ensure an adequate measurement range (dynamic range). The microbial nucleic acid detection method comprises: a step in which a probe solution, which is a solution of a gold nanoparticle probe in which DNA that binds specifically to the target nucleic acid is modified with gold nanoparticles, is mixed with an extract obtained by subjecting a sample to nucleic acid extraction treatment, sodium chloride, at least, is also added and the mixture is heated to prepare a sample mixed solution; a step in which an absorption spectrum of the probe solution is acquired; a step in which an absorption spectrum of a blank solution is acquired, the blank solution being is a sample-free solution obtained by adding sodium chloride to the probe solution and heating; a step in which an absorption spectrum of the sample mixed solution is acquired; and a calculation step in which the concentration of the target nucleic acid in the sample is estimated based on the absorption spectra of the probe solution, the blank solution, and the sample mixed solution.
C12Q 1/6888 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
42.
SURFACE-TREATED ALUMINUM MATERIAL, PRODUCTION METHOD FOR SAME, AND MEMBER FOR SEMICONDUCTOR PROCESSING DEVICE
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Cheung, Ling Fung
Fujitaka, Shinichiro
Fujii, Takaaki
Miyamoto, Naoki
Abrégé
The present invention enables highly accurate markerless tracking of tumor movement on the basis of a real-time image. A movement tracking device that tracks the movement of a target and a tissue in a specific region is provided, comprising: a movement estimating unit that acquires an estimated 3D motion which is obtained by estimating a three-dimensional movement of the target and the tissue on a real-time basis, and an estimated 2D motion which is obtained by estimating a two-dimensional movement of the target and the tissue on a real-time basis; an image acquisition unit that acquires a reference 2D image which is a two-dimensional image of the specific region at a predetermined reference time and a real-time 2D image which is a two-dimensional image of the specific region at real time; an image simulator that uses the estimated 2D motion and the reference 2D image to generate a pseudo real-time 2D image that simulates the two-dimensional image of the specific region at real time; and an estimation correction unit that corrects the estimated 3D motion on the basis of a comparison between the pseudo real-time 2D image and the real-time 2D image.
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
A61N 5/10 - RadiothérapieTraitement aux rayons gammaTraitement par irradiation de particules
44.
CALIBRATION METHOD FOR PHASE MODULATOR, CALIBRATION METHOD FOR BALANCED PHOTODETECTOR, AND CALIBRATION SYSTEM FOR PHASE MODULATOR
National Institute of Information and Communications Technology (Japon)
National University Corporation Hokkaido University (Japon)
Inventeur(s)
Fujiwara, Mikio
Takeoka, Masahiro
Sasaki, Masahide
Tomita, Akihisa
Abrégé
A phase modulator calibration method includes steps of: providing a first delay interferometer to be used as a phase calibration reference and a second delay interferometer in which a phase modulator to be calibrated is installed in an optical path; for each of the first and second delay interferometers, measuring a delay time based on a time interval between pulses split from one input pulse and synchronizing the delay time with a cycle of a transmission clock; for the first delay interferometer, adjusting a phase difference so that input continuous-wave laser light produces an intensity-enhancing interference at an output; and determining the control signal with a calibration circuitry formed by connecting the first delay interferometer as a front stage and the second delay interferometer as a rear stage in a cascaded manner.
G02F 1/01 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p. ex. commutation, ouverture de porte ou modulationOptique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur
G02F 1/21 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p. ex. commutation, ouverture de porte ou modulationOptique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur par interférence
45.
SHEET-LIKE JOINING MATERIAL, METHOD FOR PRODUCING JOINED BODY, AND JOINED BODY
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Yonezawa, Tetsu
Tsukamoto, Hiroki
Abrégé
6486488O including slightly oxidized copper-coated copper particles being slightly oxidized copper particles having an average particle diameter of 1 nm to 20 nm inclusive and a medium, wherein the content of the slightly oxidized copper-coated copper particles is greater than 85 mass %.
B22F 7/08 - Fabrication de couches composites, de pièces ou d'objets à base de poudres métalliques, par frittage avec ou sans compactage de pièces ou objets composés de parties différentes, p. ex. pour former des outils à embouts rapportés avec une ou plusieurs parties non faites à partir de poudre
H01B 1/22 - Matériau conducteur dispersé dans un matériau organique non conducteur le matériau conducteur comportant des métaux ou des alliages
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Ito, Hajime
Kubota, Koji
Abrégé
The present invention addresses the problem of providing: (i) a reduction method for reducing a substrate, which is composed of one or more compounds each having an unsaturated bond, by means of a mechanochemical treatment using at least a proton source and a metal including one or more elements selected from among alkali metals and alkaline earth metals; and (ii) a reduction method which enables the achievement of a reaction product that is similar to the reaction product by Birch reduction, with which the reaction can be carried out under mild temperature conditions in the ambient atmosphere without using liquid ammonia and high activity in the reduction reaction can be exhibited without using any solvent or substantially without using an organic solvent, and which enables the achievement of a reaction product with a high yield within a short time by a simple operation and is applicable to a wide range of substrates. The present invention provides, as a means for solving the problem, a reduction method for reducing a substrate (A) by a mechanochemical treatment using at least a metal (B) and a proton source (C), wherein: the substrate (A) is composed of one or more compounds each having an unsaturated bond; and the metal (B) includes one or more elements that are selected from among alkali metals and alkaline earth metals.
C07C 13/23 - Hydrocarbures monocycliques ou leurs dérivés hydrocarbonés acycliques à cycle hexagonal à cycle du cyclohexadiène
C07C 13/48 - Naphtalènes complètement ou partiellement hydrogénés
C07C 13/58 - Anthracènes complètement ou partiellement hydrogénés
C07C 13/547 - Hydrocarbures polycycliques ou leurs dérivés hydrocarbonés acycliques à cycles condensés à trois cycles condensés un cycle au moins n'étant pas un cycle à six chaînons, les autres cycles étant au plus des cycles à six chaînons
C07C 15/18 - Hydrocarbures polycycliques non condensés contenant au moins un groupe de formule
C07C 29/19 - Préparation de composés comportant des groupes hydroxyle ou O-métal liés à un atome de carbone ne faisant pas partie d'un cycle aromatique à six chaînons par hydrogénation de liaisons doubles ou triples carbone-carbone dans des cycles aromatiques à six chaînons
C07C 33/14 - Alcools contenant des cycles autres que des cycles aromatiques à six chaînons contenant des cycles à six chaînons
C07C 41/20 - Préparation d'éthers par des réactions ne formant pas de liaisons sur l'oxygène de la fonction éther par hydrogénation de liaisons doubles ou triples carbone-carbone
C07C 43/303 - Composés comportant des groupes les atomes de carbone de l'acétal étant liés à des atomes de carbone acycliques
C07C 51/36 - Préparation d'acides carboxyliques, de leurs sels, halogénures ou anhydrides par des réactions ne créant pas de groupes carboxyle par hydrogénation de liaisons non saturées carbone-carbone
C07C 57/26 - Composés non saturés comportant des groupes carboxyle liés à des atomes de carbone acycliques contenant des cycles autres que des cycles aromatiques à six chaînons
C07C 231/12 - Préparation d'amides d'acides carboxyliques par des réactions n'impliquant pas la formation de groupes carboxamide
C07C 233/05 - Amides d'acides carboxyliques ayant des atomes de carbone de groupes carboxamide liés à des atomes d'hydrogène ou à des atomes de carbone acycliques ayant les atomes d'azote des groupes carboxamide liés à des atomes d'hydrogène ou à des atomes de carbone de radicaux hydrocarbonés non substitués avec des atomes de carbone de groupes carboxamide liés à des atomes de carbone d'un squelette carboné saturé acyclique ayant les atomes d'azote des groupes carboxamide liés à des atomes d'hydrogène ou à des atomes de carbone acycliques
C07C 269/04 - Préparation de dérivés d'acide carbamique, c.-à-d. de composés contenant l'un des groupes l'atome d'azote ne faisant pas partie de groupes nitro ou nitroso à partir d'amines avec formation de groupes carbamate
C07C 271/12 - Esters des acides carbamiques ayant des atomes d'oxygène de groupes carbamate liés à des atomes de carbone acycliques avec les atomes d'azote des groupes carbamate liés à des atomes d'hydrogène ou à des atomes de carbone acycliques à des atomes d'hydrogène ou à des atomes de carbone de radicaux hydrocarbonés non substitués
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Terai, Kota
Utsuno, Futoshi
Higuchi, Hiroyuki
Tadanaga, Kiyoharu
Miura, Akira
Rosero Navarro, Nataly Carolina
Abrégé
Provided is a sulfide solid electrolyte that has a novel crystal structure and exhibits an ionic conductivity, the sulfide solid electrolyte containing a lithium atom, a phosphorus atom, a sulfur atom, and at least one kind of halogen atom selected from a chlorine atom and a bromine atom, and having a specific diffraction peak in powdery X-ray diffractometry using CuKα line, and a method for producing a sulfide solid electrolyte, the method including mixing a solvent 1 having a heteroatom and a raw material 1 containing specific atoms to prepare a mixture, preparing a solution that contains a raw material 2 containing a halogen atom and a solvent 2 having a heteroatom, mixing the mixture and the solution to prepare a fluid, and heating the fluid.
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Nomura, Takahiro
Ade, Kurniawan
Hashizaki, Katsuo
Sakai, Susumu
Koikari, Souji
Abrégé
Provided is a reaction heat utilization system capable of enhancing temperature controllability in a reactor and utilizing reaction heat generated in the reactor with higher efficiency. This reaction heat utilization system comprises: a reactor that accommodates a heat storage unit including a plurality of latent heat storage bodies; a supply unit that supplies one of a first fluid and a second fluid to the reactor in a switchable manner; and a discharge unit that discharges generated fluid generated through a chemical reaction from the reactor. Each latent heat storage body has a core part including a latent heat storage material, and a shell part that has a melting point higher than that of the latent heat storage material and that seals the latent heat storage material therein. The first fluid includes a starting fluid that causes an exothermic reaction in the reactor and/or the second fluid includes a starting fluid that causes an endothermic reaction in the reactor. The reaction heat utilization system is configured to switch alternately between a heat storage mode in which heat is stored in the heat storage unit as a result of the first fluid being supplied from the supply unit to the reactor, and a heat radiation mode in which heat is released from the heat storage unit as a result of the second fluid being supplied from the supply unit to the reactor.
F28D 20/02 - Appareils ou ensembles fonctionnels d'accumulation de chaleur en généralAppareils échangeurs de chaleur de régénération non couverts par les groupes ou utilisant la chaleur latente
C07C 1/04 - Préparation d'hydrocarbures à partir d'un ou plusieurs composés, aucun d'eux n'étant un hydrocarbure à partir d'oxydes de carbone à partir de monoxyde de carbone avec de l'hydrogène
C07C 1/22 - Préparation d'hydrocarbures à partir d'un ou plusieurs composés, aucun d'eux n'étant un hydrocarbure à partir de composés organiques ne renfermant que des atomes d'oxygène en tant qu'hétéro-atomes par réduction
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Aoki, Yoshitaka
Toriumi, Hajime
Abrégé
Disclosed is a ceramic reversible cell which contains at least one substance selected from the group consisting of perovskite type metal oxides, hydrates of the perovskite type metal oxides, and hydrides of the perovskite type metal oxides, wherein: the at least one substance selected from the group consisting of perovskite type metal oxides, hydrates of the perovskite type metal oxides, and hydrides of the perovskite type metal oxides contains A (wherein A is at least one element selected from the group consisting of Ba, Sr and Ca), B (wherein B is at least one element selected from the group consisting of Zr, Sn, Ce, Ti and Hf) and M (wherein M is at least one element selected from the group consisting of In, Fe, Cr and Mn) as main metal atoms; and hydride ions are contained therein when equilibrium is reached by bringing dried hydrogen into contact with the ceramic reversible cell, the dried hydrogen satisfying a specific formula and having a moisture content of 20 ppm or less in terms of volume ratio at 500°C to 900°C.
C04B 35/50 - Produits céramiques mis en forme, caractérisés par leur compositionCompositions céramiquesTraitement de poudres de composés inorganiques préalablement à la fabrication de produits céramiques à base de composés de terres rares
C25B 1/042 - Hydrogène ou oxygène par électrolyse de l'eau par électrolyse de la vapeur
C25B 9/00 - Cellules ou assemblages de cellulesÉléments de structure des cellulesAssemblages d'éléments de structure, p. ex. assemblages d'électrode-diaphragmeCaractéristiques des cellules relatives aux procédés
C25B 9/23 - Cellules comprenant des électrodes fixes de dimensions stablesAssemblages de leurs éléments de structure avec des diaphragmes comprenant des membranes échangeuses d'ions dans ou sur lesquelles est incrusté du matériau pour électrode
C25B 13/04 - DiaphragmesÉléments d'espacement caractérisés par le matériau
H01M 8/12 - Éléments à combustible avec électrolytes solides fonctionnant à haute température, p. ex. avec un électrolyte en ZrO2 stabilisé
H01M 8/1246 - Éléments à combustible avec électrolytes solides fonctionnant à haute température, p. ex. avec un électrolyte en ZrO2 stabilisé caractérisés par le procédé de fabrication ou par le matériau de l’électrolyte l'électrolyte étant constitué d’oxydes
50.
ASSAY SYSTEM FOR DEVELOPING HONEYBEE ANTIVIRAL AGENT USING INHIBITION OF VIRUS-DERIVED PROTEASE AS INDICATOR
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Kamakura Masaki
Nakaoka Shinji
Abrégé
[Problem] To provide a screening method for candidate compounds capable of serving as a preventive or therapeutic agent for suppressing individual deaths of honeybees due to viral infection and to provide a preventive or therapeutic agent tied to suppression of honeybee mass deaths due to viral infection. [Solution] The cause of mass deaths of honeybee was identified as intestinal tract damage due to a virus-derived protease mediated by mites, and it was discovered that individual deaths and intestinal tract damage were suppressed in the virus infection group by administration of viral dsRNA. Furthermore, it was discovered that individual deaths in the virus infection group were suppressed by inhibiting the virus-derived protease by administering E-64 ([(2S,3S)-3-carboxyoxylan-2-carbonyl]-L-leucine (4-guanidinobutyl) amide hemihydrate).
C12Q 1/02 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des micro-organismes viables
A61K 31/336 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à trois chaînons, p. ex. oxirane, fumagilline
C12Q 1/37 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase faisant intervenir une peptidase ou une protéinase
51.
LIGNIN-DEGRADING CATALYST, METHOD FOR MANUFACTURING SAME, METHOD FOR DEGRADING LIGNIN, AND METHOD FOR REGENERATING LIGNIN-DEGRADING CATALYST
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Yoshida, Akihiro
Sonoki, Tomonori
Irwan, Kurnia
Guan, Guoqing
Abudula, Abuliti
Masuda, Takao
Yoshikawa, Takuya
Abrégé
Provided are a lignin degradation catalyst that exhibits excellent lignin degradability and that is readily separated after degradation reaction, a method for producing the catalyst, and a method for degrading lignin. The lignin degradation catalyst according to the present invention contains a substrate and at least one metal compound immobilized on the substrate, wherein the at least one metal compound contains a copper compound. The method for producing a lignin degradation catalyst according to the present invention includes the step of brining a porous copper substrate into contact with a solution containing an oxidant to obtain a substrate having a copper compound immobilized thereon, or the step of subjecting a porous copper substrate to electro-oxidation to obtain a substrate having a copper compound immobilized thereon.
B01J 23/83 - Catalyseurs contenant des métaux, oxydes ou hydroxydes métalliques non prévus dans le groupe du cuivre ou des métaux du groupe du fer en combinaison avec des métaux, oxydes ou hydroxydes prévus dans les groupes avec des terres rares ou des actinides
B01J 23/94 - Régénération ou réactivation de catalyseurs contenant des métaux, oxydes ou hydroxydes du cuivre ou des métaux du groupe du fer
B01J 35/56 - Structures foraminées ayant des passages ou des canaux traversants, p. ex. monolithes tridimensionnels ou grilles
B01J 37/02 - Imprégnation, revêtement ou précipitation
B01J 37/34 - Irradiation ou application d'énergie électrique, magnétique ou ondulatoire, p. ex. d'ondes ultrasonores
C07C 45/32 - Préparation de composés comportant des groupes C=O liés uniquement à des atomes de carbone ou d'hydrogènePréparation des chélates de ces composés par oxydation avec l'oxygène moléculaire
C07C 51/21 - Préparation d'acides carboxyliques, de leurs sels, halogénures ou anhydrides par oxydation avec l'oxygène moléculaire
52.
METAL HEATING FURNACE, AND METHOD FOR COMBUSTING AMMONIA BY USING METAL HEATING FURNACE
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
TOHOKU UNIVERSITY (Japon)
Inventeur(s)
Kishimura Tsukasa
Miyake Tomohisa
Shimokuri Daisuke
Hashimoto Nozomu
Nakamura Hisashi
Abrégé
[Problem] To provide a metal heating furnace and a method for combusting ammonia by using a metal heating furnace, whereby it becomes possible to combust ammonia while effectively reducing nitrogen oxides. [Solution] Provided is a metal heating furnace 10 in which ammonia is combusted as a fuel with fire F from a burner nozzle 31 provided in a furnace wall 11. The metal heating furnace 10 is provided with: a plurality of ammonia injection nozzles 41, 42, 43 which are arranged at intervals in the fire F-extending direction in a ceiling wall 13 and through which ammonia is injected in a direction orthogonal to the fire F-extending direction; and a control device 100 which adjusts the amounts of ammonia to be ejected through the ammonia ejection nozzles 41, 42, 43 for every ammonia ejection nozzle 41, 42, 43.
F27D 7/02 - Alimentation en vapeur d'eau, en gaz ou en liquides
F23C 1/00 - Appareils à combustion spécialement adaptés à la combustion de plusieurs sortes de combustibles simultanément ou alternativement, au moins un des combustibles étant fluide ou étant un combustible solide en suspension dans l’air
F23C 99/00 - Matière non prévue dans les autres groupes de la présente sous-classe
F23D 14/02 - Brûleurs à gaz avec prémélangeurs, c.-à-d. dans lesquels le combustible gazeux est mélangé à l'air de combustion en amont de la zone de combustion
F23J 7/00 - Aménagement des dispositifs d'introduction de produits chimiques dans le foyer
F23K 5/00 - Alimentation en d'autres combustibles ou distribution d'autres combustibles pour les appareils à combustion
F23N 1/00 - Régulation de l'alimentation en combustible
F27B 5/16 - Aménagement des dispositifs d'alimentation en air ou gaz
F27B 5/18 - Aménagement des dispositifs de commande, de surveillance, d'alarme ou des dispositifs similaires
53.
LIPID NANOPARTICLE FOR EDITING MITOCHONDRIAL GENOME
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Yamada Yuma
Harashima Hideyoshi
Sato Yusuke
Ishizuka Sen
Norota Kaede
Tokeshi Manabu
Maeki Masatoshi
Abrégé
The present invention provides: lipid nanoparticles that are for editing mitochondrial genome and that each include an RNA-guided DNA nuclease and a guide RNA; and a dispersion containing, in a dispersion medium, said lipid nanoparticles as a dispersoid. The present invention also provides a pharmaceutical composition that contains said lipid nanoparticles and that is for preventing or treating mitochondrial diseases, particularly a pharmaceutical composition for preventing or treating MELAS. The present invention further provides methods for producing the lipid nanoparticles and the dispersion.
C12N 15/88 - Introduction de matériel génétique étranger utilisant des procédés non prévus ailleurs, p. ex. co-transformation utilisant la micro-encapsulation, p. ex. utilisant des vésicules liposomiques
A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
A61K 47/24 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant des atomes autres que des atomes de carbone, d'hydrogène, d'oxygène, d'halogènes, d'azote ou de soufre, p. ex. cyclométhicone ou phospholipides
A61K 47/42 - ProtéinesPolypeptidesLeurs produits de dégradationLeurs dérivés p. ex. albumine, gélatine ou zéine
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
A61P 3/00 - Médicaments pour le traitement des troubles du métabolisme
A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Murakoshi, Kei
Fukushima, Tomohiro
Minamimoto, Hiro
Oyamada, Nobuaki
Ashizawa, Daiki
Sato, Daiki
Abrégé
A water electrolysis electrode for use in a water electrolysis device in which a hydrogen-producing reaction electrode and an oxygen-producing reaction electrode are brought into contact with water and a voltage is applied between both electrodes to produce hydrogen and oxygen, said water electrolysis electrode having, on at least a portion of a surface thereof, one or more structures selected from the group consisting of a plurality of nanostructures and a plurality of microstructures which, during water electrolysis, interact with at least one type of polarization selected from the group consisting of electronic polarization of a chemical reaction intermediate during water electrolysis and vibrational polarization of water molecules.
C25B 11/02 - ÉlectrodesLeur fabrication non prévue ailleurs caractérisées par la configuration ou la forme
C25B 1/04 - Hydrogène ou oxygène par électrolyse de l'eau
C25B 9/00 - Cellules ou assemblages de cellulesÉléments de structure des cellulesAssemblages d'éléments de structure, p. ex. assemblages d'électrode-diaphragmeCaractéristiques des cellules relatives aux procédés
C25B 11/04 - ÉlectrodesLeur fabrication non prévue ailleurs caractérisées par le matériau
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Ito, Koichiro
Shinagawa, Naofumi
Abrégé
This forceps system comprises: a tubular guide sheath (2); a forceps (3) that has an openable and closable gripping section (7), and is inserted into the guide sheath (2) in the longitudinal direction of the guide sheath (2); and an orientation adjustment mechanism (8, 9) that is provided in the guide sheath (2) and the forceps (3), and adjusts the orientation of the gripping section (7) relative to the guide sheath (2). The guide sheath (2) has a shielding section (4) provided in a circumferential portion of a tip end part of the guide sheath (2). The orientation adjustment mechanism (8, 9) adjusts the gripping section (7) disposed at the tip end part of the guide sheath (2) to a predetermined orientation where the openable and closable side of the gripping section (7) faces away from the shielding section (4).
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
NATIONAL UNIVERSITY CORPORATION, NAGASAKI UNIVERSITY (Japon)
Inventeur(s)
Sato, Kazuki
Onozaka, Ken
Mishima, Taichi
Ito, Yuki
Ota, Hiroaki
Igarashi, Hajime
Otomo, Yoshitsugu
Abrégé
Provided is a magnetic core in which power feeding efficiency and robustness against position error are increased. A magnetic core of the present disclosure comprises: a base portion; a column portion extending upward from the base portion; a cap portion connected to the column portion; and a wall portion extending upward from the base portion and provided to surround the column portion in plan view. The cap portion opposes the base portion in the vertical direction, and extends outside the column portion in plan view. The cap portion is smaller than the base portion in plan view, and is positioned inside the outer edge of the wall portion. The upper end of the wall portion is positioned lower than the upper surface of the cap portion.
H02J 50/10 - Circuits ou systèmes pour l'alimentation ou la distribution sans fil d'énergie électrique utilisant un couplage inductif
H02J 50/90 - Circuits ou systèmes pour l'alimentation ou la distribution sans fil d'énergie électrique mettant en œuvre la détection ou l'optimisation de la position, p. ex. de l'alignement
57.
LIFE DESIGN PROPOSAL SYSTEM AND LIFE DESIGN PROPOSAL METHOD
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Nakamura Takahiro
Takemoto Takashi
Lei Miaomei
Nagayama Masaharu
Nakayama Madoka
Abrégé
This life design proposal system comprises a computer having a calculation device that executes a predetermined calculation process, and a storage device connected to the calculation device, wherein the calculation device includes a reception unit that receives a life plan desired by a user and a balance of well-being desired by the user; an extraction unit that extracts a subject that matches the received life plan; and an output unit that outputs data on a plurality of role models including the age at which a life event occurred and well-being at the time of each life event, on the basis of the satisfaction level of the extracted subject in the life events.
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
TOHOKU UNIVERSITY (Japon)
ROZAI KOGYO KAISHA,LTD. (Japon)
Inventeur(s)
Kishimura Tsukasa
Miyake Tomohisa
Sato Junichi
Shimokuri Daisuke
Hashimoto Nozomu
Nakamura Hisashi
Takemura Sinichiro
Abrégé
[Problem] To provide an industrial furnace that can combust ammonia effectively and facilitate reduction in nitrogen oxides. [Solution] An industrial furnace 1 uses flame F from a burner 10 to combust ammonia which is supplied along with combustion air and fuel gas to the burner 10. Tips of tube-shaped ammonia injection nozzles 21, 22, 23, 24, which are arranged in communication with the wall surface of a furnace body 2 in the furnace 1 and which are provided so as to inject only ammonia, are protruded inward to the furnace body 2 from the wall surface. The entirety of the ammonia injection nozzles 21, 22, 23, 24 are formed by using a catalyst C which decomposes ammonia into hydrogen and nitrogen.
F23K 5/00 - Alimentation en d'autres combustibles ou distribution d'autres combustibles pour les appareils à combustion
F23C 1/00 - Appareils à combustion spécialement adaptés à la combustion de plusieurs sortes de combustibles simultanément ou alternativement, au moins un des combustibles étant fluide ou étant un combustible solide en suspension dans l’air
F23C 13/08 - Appareils dans lesquels la combustion a lieu en présence de matériau catalytique caractérisé par le matériau catalytique
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Kobayashi Hiroaki
Iimura Reona
Kawasaki Shiori
Homma Itaru
Abrégé
The present invention relates to manganese dioxide suitable as a raw material of an electrode material for a polyvalent metal ion secondary battery. The manganese dioxide according to the present invention has an α-type crystal structure. Ammonium ions are incorporated in the α-type crystal structure. The manganese dioxide according to the present invention has an average crystallite size of at most 5.0 nm, as measured using the Scherrer method based on X-ray diffraction, and a BET specific surface area of at least 100 m2/g.
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Noro Shin-Ichiro
Abrégé
A solid material sustainedly releasing ethylene gas, the solid material comprising a silver-containing zeolite and a dehydrating agent, wherein a layer comprising the silver-containing zeolite and a layer comprising the dehydrating agent are preferably arranged so that the ethylene gas released from the silver-containing zeolite passes through the layer comprising the dehydrating agent.
A23B 7/152 - Conservation ou mûrissement à l'aide de produits chimiques non couverts par les groupes ou sous forme de gaz, p. ex. fumigationCompositions ou appareils à cet effet en atmosphère contrôlée comportant d'autres gaz en plus des gaz suivants: CO2, N2, O2 ou H2O
A23L 19/12 - Produits à base de fruits ou de légumesLeur préparation ou leur traitement de tubercules ou d'autres racines contenant de l'amidon de pommes de terre
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Kobayashi Hiroaki
Iimura Reona
Kawasaki Shiori
Homma Itaru
Abrégé
The present invention relates to manganese dioxide suitable as a raw material of an electrode material for a polyvalent metal ion secondary battery. The manganese dioxide according to the present invention has an α-type crystal structure. Ammonium ions are incorporated in the α-type crystal structure. The manganese dioxide according to the present invention has an average crystallite size of at most 5.0 nm, as measured using the Halder-Wagner method based on X-ray diffraction, and a BET specific surface area of at least 100 m2/g.
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Takayanagi, Taisuke
Yamada, Takahiro
Hirayama, Shusuke
Miyazaki, Koichi
Kobashi, Keiji
Aoyama, Hidefumi
Hashimoto, Takayuki
Katoh, Norio
Taguchi, Hiroshi
Yasuda, Koichi
Onodera, Yasuhito
Abrégé
A treatment planning system is configured to create a treatment planning for radiotherapy and includes a processing device and a memory. The memory stores a plurality of calculation models, and the processing device uses at least two of the plurality of calculation models to calculate calculation values of biological effect indices representing an effect of radiotherapy with respect to a condition for radiotherapy, and searches for the condition so that at least two of the calculation values to be calculated approach a predetermined target value.
A61N 5/10 - RadiothérapieTraitement aux rayons gammaTraitement par irradiation de particules
63.
METHOD FOR DETECTING AMYLOID-ß BOUND TO BRAIN-NEURONALCELL-DERIVED EXOSOME IN BLOOD, KIT FOR DETECTION OF AMYLOID-ß BOUND TO BRAIN-NEURONAL-CELL-DERIVED EXOSOME IN BLOOD, AND METHOD FOR EVALUATING ACCUMULATION LEVEL OF AMYLOID-ß IN BRAIN
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Makino, Yoichi
Hirase, Takumi
Yuyama, Kohei
Abrégé
There are provided a method for detecting amyloid-β bound to a brain-neuronal-cell-derived exosome in blood, the method including: a step of binding amyloid-β bound to the brain-neuronal-cell-derived exosome in blood to an amyloid-β-specific binding substance that specifically binds to amyloid-β, labeled with a nucleic acid fragment; and a step of detecting the amyloid-β-specific binding substance, and a method for evaluating an accumulation level of amyloid-β in a brain, the method including: a step of detecting amyloid-β bound to the brain-neuronal-cell-derived exosome in blood; and a step of evaluating an accumulation level of amyloid-β in a brain based on the detected amount of the amyloid-β.
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
64.
POLYOXYETHYLENE DERIVATIVES AND CONJUGATES THEREOF
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
OSAKA UNIVERSITY (Japon)
NOF CORPORATION (Japon)
Inventeur(s)
Onoda, Akira
Hayashi, Takashi
Hamura, Ken
Suzuki, Akira
Kishida, Satoshi
Abrégé
Polyoxyethylene derivatives represented by the following formula (1) provided by the present invention:
Polyoxyethylene derivatives represented by the following formula (1) provided by the present invention:
Polyoxyethylene derivatives represented by the following formula (1) provided by the present invention:
wherein the symbols in the formula are as defined in the specification, can form conjugates with polypeptide that can be degraded over a long time under physiological conditions to release the polypeptide.
A61K 47/60 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique macromoléculaire, p. ex. une molécule oligomérique, polymérique ou dendrimérique obtenu par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyurées ou polyuréthanes le composé organique macromoléculaire étant un oligomère, un polymère ou un dendrimère de polyoxyalkylène, p. ex. PEG, PPG, PEO ou polyglycérol
A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Kamps, Landon Thomas
Nagata, Harunori
Hirai, Shota
Leung, Yownin Albert
Nobuhara, Yuki
Abrégé
The present disclosure is directed to an ignition device including a housing, a bulk fuel, and at least two lead wires as electrodes. The bulk fuel is made of a plastic material, such as polylactic acid (PLA) or epoxy resin. The bulk fuel contains an internally dispersed powdery conductive material, thereby obtaining a conductive solid fuel. One end of the lead wire is partially embedded in the bulk fuel. The other end of the lead wire is connected to a power source. A portion of the bulk fuel is gasified by energizing the lead wire, and the gasified fuel is combusted by reaction with an oxidant.
F02K 9/95 - Moteurs-fusées, c.-à-d. ensembles fonctionnels portant à la fois le combustible et son oxydantLeur commande caractérisés par des moyens ou des aménagements de démarrage ou d'allumage
F02K 9/08 - Moteurs-fusées, c.-à-d. ensembles fonctionnels portant à la fois le combustible et son oxydantLeur commande utilisant des propergols solides
66.
DIAGNOSIS METHOD AND TESTING METHOD FOR MUSCULAR DYSTROPHY IN CAT
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Yamazaki Jumpei
Matsumoto Yuki
Yokoyama Nozomu
Abrégé
Provided are a diagnosis method and a testing method for muscular dystrophy in cats. The diagnosis method is for determining whether a cat under examination has developed muscular dystrophy, wherein information about the dystrophin gene of the cat under examination is acquired from a biological sample collected from the cat under examination, and on the basis of the information, it is determined whether the cat under examination has developed muscular dystrophy. Further, the testing method is for determining whether a cat under examination or a descendant thereof has a risk of developing muscular dystrophy, wherein information about the dystrophin gene of the cat under examination is acquired from a biological sample collected from the cat under examination, and on the basis of the information, it is determined whether the cat under examination or a descendant thereof has a risk of developing muscular dystrophy.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
C12N 15/12 - Gènes codant pour des protéines animales
C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
67.
METHOD FOR DETECTING AUTOANTIGENS OF IMMUNE-MEDIATED DISEASE, AND KIT FOR DETECTING AUTOANTIGENS OF IMMUNE-MEDIATED DISEASE
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Yaguchi, Hiroaki
Watanabe, Masashi
Takahashi, Hidehisa
Hatakeyama, Shigetsugu
Yabe, Ichiro
Abrégé
The present invention relates to a method for comprehensively detecting autoantigens of an immune-mediated disease in a short period of time. A method for detecting autoantigens of an immune-mediated disease according to the present invention comprises: a step for bringing antibodies obtained from an immune-mediated-disease sample, and a lysate of animal tissue, into contact with each other; a step for eluting proteins that are bonded to the antibodies; and a step for performing mass spectrometry of the eluted proteins without performing electrophoresis.
G01N 33/564 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour complexes immunologiques préexistants ou maladies auto-immunes
G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
68.
PHARMACEUTICAL COMPOSITION FOR TRANSNASAL ADMINISTRATION
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Uchimura, Seiichi
Nakatsuka, Shuji
Kawabori, Masahito
Abrégé
The purpose of the present disclosure is to provide a pharmaceutical composition having an excellent therapeutic effect on the treatment of central nervous system diseases. A pharmaceutical composition for transnasal administration to be used for treating central nervous system diseases and containing a purified product of extracellular vesicles, in which the purified product of extracellular vesicles is obtained by a method for producing a purified product of extracellular vesicles, the method comprising: (i) a purification step in which a solution to be treated containing extracellular vesicles and foreign substances is brought into contact with an exclusive anion exchange carrier to obtain a treated solution containing the extracellular vesicles; and (ii) a membrane filtration step in which the treated solution is subjected to membrane filtration to obtain a concentrated solution of the extracellular vesicles. The pharmaceutical composition for transnasal administration has an excellent therapeutic effect on the treatment of central nervous system diseases.
A61K 35/12 - Substances provenant de mammifèresCompositions comprenant des tissus ou des cellules non spécifiésCompositions comprenant des cellules souches non embryonnairesCellules génétiquement modifiées
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Sato, Yusuke
Sasaki, Kosuke
Harashima, Hideyoshi
Abrégé
The present invention provides lipid nanoparticles that contain a pH-sensitive cationic lipid and a polyalkylene glycol-modified lipid. The pH-sensitive cationic lipid fraction of the total lipids that constitute the lipid nanoparticles is 10-25 mol %, the polyalkylene glycol-modified lipid fraction of the total lipids that constitute the lipid nanoparticles is 0.5-1.75 mol %, and the number average particle size of the lipid nanoparticles is at least 150 nm.
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Tasaka, Yuji
Yoshida, Taiki
Ohie, Kohei
Abrégé
[Problem] To provide an ultrasonic physical properties measurement device that suppresses the generation of a secondary flow inside a cylinder, is more portable, and can suppress changes in physical properties.
[Problem] To provide an ultrasonic physical properties measurement device that suppresses the generation of a secondary flow inside a cylinder, is more portable, and can suppress changes in physical properties.
[Solution] An ultrasonic physical properties measurement device 1 that: uses ultrasonic waves to measure the flow velocity profile of fluids that flow inside a cylinder 2, by rotating the cylinder 2 backwards and forwards in a fixed cycle; and calculates the physical properties of fluid from the flow velocity profile. The cylinder 2: has an upper end surface 21 and lower end surface 22 that are penetrated such that fluid can flow therethrough; and comprises a rotation mechanism 3 that supports all or part of the cylinder 2 in a state of immersion in the fluid and rotates the cylinder 2 backwards and forwards.
G01F 1/66 - Mesure du débit volumétrique ou du débit massique d'un fluide ou d'un matériau solide fluent, dans laquelle le fluide passe à travers un compteur par un écoulement continu en mesurant la fréquence, le déphasage, le temps de propagation d'ondes électromagnétiques ou d'autres types d'ondes, p. ex. en utilisant des débitmètres à ultrasons
71.
Dispersion Solution for X-Ray Target, Prefilled Syringe Filled with Same, and Powder for X-Ray Target
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Yonezawa, Tetsu
Shirato, Hiroki
Miyamoto, Naoki
Abrégé
A dispersion for an X-ray target in which gold nanoparticles and sodium alginate or a calcium phosphate-based bone reinforcing material are dispersed, in which the gold nanoparticles are in contact with the sodium alginate or the calcium phosphate-based bone reinforcing material.
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Oji Holdings Corporation (Japon)
Inventeur(s)
Miyatake, Yukiko
Shigetomi, Kaori
Tokuno, Hisako
Dai, Kotaro
Shinotsuka, Kei
Abrégé
A cell mass-forming member that is capable of easily forming a cell mass and superior in industrial mass productivity; a culture container equipped with the cell mass-forming member; a method for producing cultured cells using the cell mass-forming member; and cultured cells with a cell mass-forming member that are equipped with the cell mass-forming member. The cell mass-forming member has a base material, an adhesion inhibition area and a cell adhesion area are formed on the surface of the base material; a micro-concavo-convex structure area including a plurality of convex portions is formed in the cell adhesion area; and a hydrophilic coating layer is formed on both the adhesion inhibition area and the cell adhesion area. The culture container and the cultured cells with a cell mass-forming member are equipped with the cell mass-forming member. The method for producing cultured cells includes using the cell mass-forming member.
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Ito, Hajime
Kubota, Koji
Abrégé
The problem addressed is: to provide a polymer mechanoradical initiator obtained by mechanochemical treatment of an organic polymer material as a radical initiator for reactions in which the polymer mechanoradical initiator component is not incorporated into the reaction product; to provide a reaction method for radical reduction of an organic halogen compound using a polymer mechanoradical initiator obtained by mechanochemical treatment of an organic polymer material; to provide a reaction method for radical cyclization of an organic halogen compound using a polymer mechanoradical initiator obtained by mechanochemical treatment of an organic polymer material; or to provide a reaction method for C-H fluorination of a compound having a C-H bond based on a secondary carbon or a tertiary carbon using a polymer mechanoradical initiator obtained by mechanochemical treatment of an organic polymer material. Provided as a solution are: (i) a polymer mechanoradical initiator obtained by mechanochemical treatment of an organic polymer material, wherein the polymer mechanoradical initiator is used in reactions in which the polymer mechanoradical initiator is not incorporated into the reaction product; (ii) a reaction method for radical reduction and/or radical cyclization of a substrate using a polymer mechanoradical initiator, wherein the reaction method includes a step that performs mechanochemical treatment of at least an organic polymer material and a substrate inside a reactor and the substrate contains an organic halogen compound; and (iii) a reaction method for C-H fluorination of a substrate using a polymer mechanoradical initiator, wherein the reaction method includes a step that performs mechanochemical treatment of at least an organic polymer material, a substrate, and a fluorination reagent inside a reactor and the substrate contains a compound having a C-H bond based on a secondary carbon or a tertiary carbon.
C07C 45/65 - Préparation de composés comportant des groupes C=O liés uniquement à des atomes de carbone ou d'hydrogènePréparation des chélates de ces composés par des réactions ne créant pas de groupe C=O par élimination d'atomes d'hydrogène ou de groupes fonctionnelsPréparation de composés comportant des groupes C=O liés uniquement à des atomes de carbone ou d'hydrogènePréparation des chélates de ces composés par des réactions ne créant pas de groupe C=O par hydrogénolyse de groupes fonctionnels
C07C 209/74 - Préparation de composés contenant des groupes amino liés à un squelette carboné à partir d'amines, par des réactions n'impliquant pas de groupes amino, p. ex. réduction d'amines non saturées, aromatisation ou substitution du squelette carboné par halogénation, halogénhydratation, déshalogénation ou déshalogénhydratation
C07C 211/54 - Composés contenant des groupes amino liés à un squelette carboné ayant des groupes amino liés à des atomes de carbone de cycles aromatiques à six chaînons du squelette carboné ayant des groupes amino liés à deux ou trois cycles aromatiques à six chaînons
C07D 209/30 - IndolesIndoles hydrogénés avec des hétéro-atomes ou avec des atomes de carbone comportant trois liaisons à des hétéro-atomes, avec au plus une liaison à un halogène, liés directement aux atomes de carbone de l'hétérocycle
C07D 307/06 - Composés hétérocycliques contenant des cycles à cinq chaînons comportant un atome d'oxygène comme unique hétéro-atome du cycle non condensés avec d'autres cycles ne comportant pas de liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec uniquement des atomes d'hydrogène ou des radicaux ne contenant que des atomes d'hydrogène et de carbone, liés directement aux atomes de carbone du cycle
C07D 307/79 - Benzo [b] furannesBenzo [b] furannes hydrogénés avec uniquement des atomes d'hydrogène, des radicaux hydrocarbonés ou des radicaux hydrocarbonés substitués, liés directement aux atomes de carbone de l'hétérocycle
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
TOHOKU UNIVERSITY (Japon)
Inventeur(s)
Takemura Sinichiro
Inoue Takeshi
Hirose Akira
Hashimoto Nozomu
Nakamura Hisashi
Abrégé
[Problem] To provide an industrial furnace which burns ammonia effectively while achieving a reduction in nitrogen oxides, without a particular increase in cost. [Solution] In an industrial furnace 100 equipped with a regenerative burner comprising a pair of burners 10, 20: air nozzles 11, 21 for discharging combustion air into the furnace are provided in furnace walls 101, 102 in positions at the centers of the burners 10, 20; fuel nozzles 12, 22 for discharging a fossil fuel into the furnace are provided on one of two sides sandwiching the air nozzles 11, 21, and ammonia nozzles 13, 23 for discharging ammonia into the furnace are provided on the other side; and the ammonia is burned using the burners 10, 20.
F23D 14/22 - Brûleurs à gaz sans prémélangeur, c.-à-d. dans lesquels le combustible gazeux est mélangé à l'air de combustion à l'arrivée dans la zone de combustion avec des conduits d'alimentation en air et en gaz séparés, p. ex. avec des conduits disposés parallèlement ou se croisant
F23C 1/00 - Appareils à combustion spécialement adaptés à la combustion de plusieurs sortes de combustibles simultanément ou alternativement, au moins un des combustibles étant fluide ou étant un combustible solide en suspension dans l’air
F23D 14/84 - Diffusion de la flamme ou autres moyens pour lui donner une forme particulière
NATIONAL AGRICULTURE AND FOOD RESEARCH ORGANIZATION (Japon)
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Nippon Soda Co., Ltd. (Japon)
Inventeur(s)
Kushida, Atsuhiko
Sakata, Itaru
Tanino, Keiji
Kato, Kousuke
Itabashi, Takuya
Kanazawa, Jun
Ikeda, Yuto
Kitayama, Takashi
Koizumi, Satoshi
Osawa, Yoko
Inoue, Tsutomu
Abrégé
An object of the present invention is to provide an industrially easily available hatching factor on Globodera pallida larvae, a control agent and a control method using the same. The Globodera pallida control agent of the present invention contains, as an active ingredient, at least one selected from a compound of formula (I) below, a stereoisomer thereof, and a salt thereof [wherein Ar represents a substituted or unsubstituted phenyl group or the like; R1 each independently represents a group such as a substituted or unsubstituted C1 to 6 alkyl group and a substituted or unsubstituted C2 to 6 alkenyl group; R2 represents a hydrogen atom or a substituted or unsubstituted C1 to 6 alkyl group; the partial structure —Y—X— represents a group represented by *—N(Rb)—C(═X1)—**; X1 each independently represents an oxygen atom or a sulfur atom; Rb represents hydrogen atom or the like; where * indicates a binding position to the carbon atom having two R1, and ** indicates a binding position to Z; and Z represents a substituted or unsubstituted methylene group, or a substituted or unsubstituted dimethylene group.]
An object of the present invention is to provide an industrially easily available hatching factor on Globodera pallida larvae, a control agent and a control method using the same. The Globodera pallida control agent of the present invention contains, as an active ingredient, at least one selected from a compound of formula (I) below, a stereoisomer thereof, and a salt thereof [wherein Ar represents a substituted or unsubstituted phenyl group or the like; R1 each independently represents a group such as a substituted or unsubstituted C1 to 6 alkyl group and a substituted or unsubstituted C2 to 6 alkenyl group; R2 represents a hydrogen atom or a substituted or unsubstituted C1 to 6 alkyl group; the partial structure —Y—X— represents a group represented by *—N(Rb)—C(═X1)—**; X1 each independently represents an oxygen atom or a sulfur atom; Rb represents hydrogen atom or the like; where * indicates a binding position to the carbon atom having two R1, and ** indicates a binding position to Z; and Z represents a substituted or unsubstituted methylene group, or a substituted or unsubstituted dimethylene group.]
A01N 43/18 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un ou plusieurs atomes d'oxygène ou de soufre comme uniques hétéro-atomes du cycle avec un hétéro-atome des cycles à six chaînons avec le soufre comme hétéro-atome du cycle
A01N 43/08 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un ou plusieurs atomes d'oxygène ou de soufre comme uniques hétéro-atomes du cycle avec un hétéro-atome des cycles à cinq chaînons avec l'oxygène comme hétéro-atome du cycle
A01N 43/10 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un ou plusieurs atomes d'oxygène ou de soufre comme uniques hétéro-atomes du cycle avec un hétéro-atome des cycles à cinq chaînons avec le soufre comme hétéro-atome du cycle
A01N 43/36 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un atome d'azote comme unique hétéro-atome du cycle des cycles à cinq chaînons
A01N 43/38 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un atome d'azote comme unique hétéro-atome du cycle des cycles à cinq chaînons condensés avec des carbocycles
A01N 43/40 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un atome d'azote comme unique hétéro-atome du cycle des cycles à six chaînons
A01N 43/80 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec des atomes d'azote et des atomes d'oxygène ou de soufre, comme hétéro-atomes du cycle des cycles à cinq chaînons avec un atome d'azote et soit un atome d'oxygène, soit un atome de soufre, en positions 1,2
CATALYST STRUCTURE FOR SYNTHESIS GAS PRODUCTION, SYNTHESIS GAS PRODUCTION DEVICE, AND METHOD FOR PRODUCING CATALYST STRUCTURE FOR SYNTHESIS GAS PRODUCTION
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Banba, Yuichiro
Fukushima, Masayuki
Kawamata, Yuki
Iwano, Yuki
Mori, Tomohiko
Fujikawa, Takashi
Masuda, Takao
Nakasaka, Yuta
Yoshikawa, Takuya
Abrégé
A catalyst structure for synthesis gas production is used to produce a synthesis gas that includes carbon monoxide and hydrogen. The structure includes a carrier with a porous structure that comprises a zeolite-type compound; first catalyst particles that contain at least one iron-group element selected from the group consisting of nickel, iron, and cobalt; and a second catalyst that contains at least one transition metal element with redox capacity. The carrier includes, inside thereof, mutually communicating passages; the first catalyst particles are present at least in the passages of the carrier; and the second catalyst is present at least in the interior or on an outer surface of the carrier.
B01J 37/02 - Imprégnation, revêtement ou précipitation
B01J 37/10 - Traitement thermique en présence d'eau, p. ex. de vapeur d'eau
C01B 3/40 - Production d'hydrogène ou de mélanges gazeux contenant de l'hydrogène par réaction de composés organiques gazeux ou liquides avec des agents gazéifiants, p. ex. de l'eau, du gaz carbonique, de l'air par réaction d'hydrocarbures avec des agents gazéifiants avec des catalyseurs caractérisée par le catalyseur
77.
METHOD FOR PRODUCING HOMO-COUPLING REACTION PRODUCT
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Ito, Hajime
Kubota, Koji
Abrégé
The present invention addresses the problem of providing a method for producing a homo-coupling reaction product, whereby it becomes possible to substantially eliminate the use of an organic solvent, to carry out a reaction under a mild reaction condition by a simple reaction operation, to use a broad range of organic halogen compounds as starting materials, to produce a reaction product within a short time with high yield, and to produce a reaction product having a higher molecular weight. As a solution for the problem, a method for producing a homo-coupling reaction product of an organic halogen compound represented by formula (I): A1mm (wherein A1 represents any one of an m-valent aromatic hydrocarbon group which may have a substituent, an m-valent aromatic heterocyclic group which may have a substituent, an m-valent heterocyclic group which may have a substituent, an m-valent aliphatic hydrocarbon group which may have a substituent, and an m-valent unsaturated aliphatic hydrocarbon group which may have a substituent; X represents any one of a chlorine atom, a bromine atom and an iodine atom, in which, when there are a plurality of X's, the X's may be the same as or different from each other; and m represents the number of X's and is an integer of 1 or more) is provided, in which the organic halogen compound represented by formula (I) is reacted by a mechano-chemical method in the presence of a nickel catalyst under the following condition (a) and/or the following condition (b). Condition (a): the amount of a solvent to be used is 0.8 mL or less relative to 1 mmol of the organic halogen compound. Condition (b): a hetero-atom-containing compound is present.
C07C 1/26 - Préparation d'hydrocarbures à partir d'un ou plusieurs composés, aucun d'eux n'étant un hydrocarbure à partir de composés organiques ne renfermant que des atomes d'halogènes en tant qu'hétéro-atomes
C07C 15/14 - Hydrocarbures polycycliques non condensés tous les groupes phényle étant directement liés
C07C 15/38 - Hydrocarbures polycycliques condensés contenant quatre cycles
C07C 15/52 - Hydrocarbures cycliques ne contenant que des cycles aromatiques à six chaînons en tant que partie cyclique substitués par des radicaux hydrocarbonés non saturés polycycliques non condensés contenant un groupe de formule
C07C 41/30 - Préparation d'éthers par des réactions ne formant pas de liaisons sur l'oxygène de la fonction éther par augmentation du nombre d'atomes de carbone, p. ex. par oligomérisation
C07C 43/205 - Éthers une liaison sur l'oxygène de la fonction éther étant sur un atome de carbone d'un cycle aromatique à six chaînons le cycle aromatique n'étant pas condensé
C07C 45/68 - Préparation de composés comportant des groupes C=O liés uniquement à des atomes de carbone ou d'hydrogènePréparation des chélates de ces composés par des réactions ne créant pas de groupe C=O par isomérisationPréparation de composés comportant des groupes C=O liés uniquement à des atomes de carbone ou d'hydrogènePréparation des chélates de ces composés par des réactions ne créant pas de groupe C=O par modification de la taille du squelette carboné par augmentation du nombre d'atomes de carbone
C07C 49/784 - Cétones comportant un groupe cétone lié à un cycle aromatique à six chaînons polycycliques tous les groupes cétone étant liés à un cycle non condensé
C07C 67/343 - Préparation d'esters d'acides carboxyliques par modification de la partie acide de l'ester sans introduction d'un groupe ester par isomérisationPréparation d'esters d'acides carboxyliques par modification de la partie acide de l'ester sans introduction d'un groupe ester par modification de la taille du squelette carboné par augmentation du nombre d'atomes de carbone
C07C 69/76 - Esters d'acides carboxyliques dont un groupe carboxyle estérifié est lié à un atome de carbone d'un cycle aromatique à six chaînons
C07C 209/68 - Préparation de composés contenant des groupes amino liés à un squelette carboné à partir d'amines, par des réactions n'impliquant pas de groupes amino, p. ex. réduction d'amines non saturées, aromatisation ou substitution du squelette carboné
C07C 211/54 - Composés contenant des groupes amino liés à un squelette carboné ayant des groupes amino liés à des atomes de carbone de cycles aromatiques à six chaînons du squelette carboné ayant des groupes amino liés à deux ou trois cycles aromatiques à six chaînons
C07C 253/30 - Préparation de nitriles d'acides carboxyliques par des réactions n'impliquant pas la formation de groupes cyano
C07C 255/51 - Nitriles d'acides carboxyliques ayant des groupes cyano liés à des atomes de carbone de cycles aromatiques à six chaînons d'un squelette carboné à des atomes de carbone de cycles aromatiques à six chaînons non condensés contenant au moins deux groupes cyano liés au squelette carboné
C07D 295/135 - Composés hétérocycliques contenant des cycles polyméthylène imine d'au moins cinq chaînons, des cycles aza-3 bicyclo [3.2.2] nonane, piperazine, morpholine ou thiomorpholine, ne comportant que des atomes d'hydrogène liés directement aux atomes de carbone du cycle avec des radicaux hydrocarbonés substitués liés aux atomes d'azote du cycle substitués par des atomes d'azote liés par des liaisons simples ou doubles avec les atomes d'azote du cycle et les atomes d'azote substituants séparés par des carbocycles ou par des chaînes carbonées interrompues par des carbocycles
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Terai Kota
Utsuno Futoshi
Higuchi Hiroyuki
Tadanaga Kiyoharu
Miura Akira
Abrégé
Provided are: a sulfide solid electrolyte production method which provides, at a high production efficiency, a sulfide solid electrolyte that contains lithium atoms, phosphorus atoms, sulfur atoms, and oxygen atoms, and that has high water resistance, the method including mixing a raw-material-containing substance and a protonic organic solvent containing oxygen atoms to thereby prepare a solution; and a sulfide solid electrolyte that contains lithium atoms, phosphorus atoms, sulfur atoms, and oxygen atoms, and that has a prescribed diffraction peak in an X-ray diffraction measurement using a CuKα ray.
H01B 13/00 - Appareils ou procédés spécialement adaptés à la fabrication de conducteurs ou câbles
C01B 25/14 - Composés de phosphore et de soufre, sélénium ou tellure
H01B 1/06 - Conducteurs ou corps conducteurs caractérisés par les matériaux conducteurs utilisésEmploi de matériaux spécifiés comme conducteurs composés principalement d'autres substances non métalliques
H01B 1/10 - Conducteurs ou corps conducteurs caractérisés par les matériaux conducteurs utilisésEmploi de matériaux spécifiés comme conducteurs composés principalement d'autres substances non métalliques sulfures
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Furusawa, Koichiro
Takahashi, Kazuyuki
Murata, Naoki
Matsushima, Hisayoshi
Nago, Toranosuke
Abrégé
An object of the present invention is to provide a separation system and a separation method that can separate deuterium from a fluid containing light hydrogen and deuterium with high separation efficiency while suppressing equipment deterioration. The present invention provides a separation system including a plurality of separation devices connected in series; each of the plurality of separation devices includes an electrolyte membrane to which an anode catalyst layer and a cathode catalyst layer are provided; a first inflow passage through which a first fluid containing light hydrogen and deuterium flows in, and a first outflow passage through which a second fluid having a lower deuterium content than that of the first fluid flows out are connected to an anode flow passage, a second inflow passage through which a third fluid flows into and a second outflow passage through which a fourth fluid containing light water and heavy water flows out are connected to a cathode flow passage; at least a separation device provided at the most upstream side among the plurality of separation devices is a first separation device into which a gas containing water vapor flows as a third fluid, and from which the third fluid and deuterium that has moved from the anode catalyst layer into the cathode catalyst layer are discharged as the fourth fluid.
C25B 9/23 - Cellules comprenant des électrodes fixes de dimensions stablesAssemblages de leurs éléments de structure avec des diaphragmes comprenant des membranes échangeuses d'ions dans ou sur lesquelles est incrusté du matériau pour électrode
C25B 9/70 - Assemblages comprenant plusieurs cellules
80.
METHOD FOR PRODUCING LAYERED COMPOSITE METAL OXIDE CRYSTAL MATERIAL
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Matsui, Masaki
Maeda, Rannosuke
Abrégé
The objective of the present invention is to provide a method for producing a layered composite metal oxide crystal material, which can be utilized as a positive electrode material for a lithium ion secondary battery or the like, in a milder condition, and methods for producing a positive electrode and a lithium ion secondary battery using the above method. The method for producing a layered composite metal oxide crystal material according to the present invention, wherein the layered composite metal oxide crystal material comprises a composite metal oxide represented by the formula: LixMOy wherein M is 1 or 2 or more of transition metals, and a part of the M may be substituted with Al and/or Mg, x is the number of 1 or more and 2 or less, y is the number of 2 or more and 3 or less, a value of x+n is 2×y, wherein n is an average valence of the transition metal M, is characterized in comprising the step of calcining a mixture comprising a monovalent anion salt of lithium, a monovalent anion salt of sodium and/or potassium, and a monovalent anion salt of the transition metal at 150° C. or higher and 400° C. or lower in the presence of a water molecule and oxygen.
H01M 4/525 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs d'oxydes ou d'hydroxydes inorganiques de nickel, de cobalt ou de fer d'oxydes ou d'hydroxydes mixtes contenant du fer, du cobalt ou du nickel pour insérer ou intercaler des métaux légers, p. ex. LiNiO2, LiCoO2 ou LiCoOxFy
H01M 4/02 - Électrodes composées d'un ou comprenant un matériau actif
H01M 4/1391 - Procédés de fabrication d'électrodes à base d'oxydes ou d'hydroxydes mixtes, ou de mélanges d'oxydes ou d'hydroxydes, p. ex. LiCoOx
H01M 4/505 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs d'oxydes ou d'hydroxydes inorganiques de manganèse d'oxydes ou d'hydroxydes mixtes contenant du manganèse pour insérer ou intercaler des métaux légers, p. ex. LiMn2O4 ou LiMn2OxFy
H01M 10/0525 - Batteries du type "rocking chair" ou "fauteuil à bascule", p. ex. batteries à insertion ou intercalation de lithium dans les deux électrodesBatteries à l'ion lithium
H01M 10/0587 - Structure ou fabrication d'accumulateurs ayant uniquement des éléments de structure enroulés, c.-à-d. des électrodes positives enroulées, des électrodes négatives enroulées et des séparateurs enroulés
81.
COMPOUND, MANUFACTURING METHOD THEREFOR, ANTIMICROBIAL AGENT, AND MEDICINAL DRUG
National University Corporation Hokkaido University (Japon)
Inventeur(s)
Takata, Masachika
Sunahara, Hirofumi
Wakimoto, Toshiyuki
Matsuda, Kenichi
Abrégé
A compound represented by Formula (1), Formula (2), or Formula (3), or a salt thereof, or a solvate thereof:
A compound represented by Formula (1), Formula (2), or Formula (3), or a salt thereof, or a solvate thereof:
wherein R1, R2, and R3 are the same or different and each represent a hydrazine group, an N-hydroxy-acetylamino group, or an N-hydroxy-formylamino group.
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Amakawa, Ayaka
Sano, Maki
Hatanaka, Hokkaido
Hatanaka, Yutaka
Abrégé
A slide number estimation apparatus (2000) acquires a slide image (30). The slide image (30) an image of a specimen slide (20) obtained from a tissue piece (10) of a subject. The slide number estimation apparatus (2000) estimates the number of tumor cells included in a region of interest (22) of the specimen slide (20) corresponding to the obtained slide image (30) using the slide image (30). The slide number estimation apparatus (2000) estimates the number of the specimen slides (20) to be obtained from the tissue piece (10) for conducting a predetermined test based on the estimated number of tumor cells.
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Sato, Mitsuteru
Takahashi, Yukihiro
Kubota, Hisayuki
Abrégé
This prediction device comprises an operational circuit, a storage device, and a communication circuit. The storage device stores correlation information showing correlations between temporal changes in the intensity of each typhoon of a plurality of typhoons and temporal changes in index values of lightning discharges that occurred in the area of influence of each typhoon. The correlation information includes time differences between the time at which the index values of lightning discharges reached a maximum and the times at which the intensity of each typhoon reached a maximum within the period of time from the outbreak of the typhoon to the extinction of the typhoon. The operational circuit acquires lightning data including the position and time of the occurrence of lightning discharges observed during a prescribed period of time, acquires typhoon data including the center position and intensity of an observed typhoon, calculates, on the basis of the lightning data, an index value of lightning discharges that occurred within a prescribed range from the center position, generates lightning discharge information indicating the temporal change in the calculated index value, and calculates a predicted value of the intensity of the typhoon on the basis of the correlation information, lightning discharge information, and the intensity of the typhoon at the latest observation time in the typhoon data.
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Shionogi & Co., Ltd. (Japon)
Inventeur(s)
Kitajima, Masaaki
Iwamoto, Ryo
Masago, Yusaku
Hayase, Shin
Katayama Adachi, Yuka
Abrégé
The present invention provides a method for quantitatively detecting virus-derived RNA and/or DNA in an environmental sample or a fecal sample with high sensitivity, and a kit for quantitatively detecting virus-derived RNA and/or DNA in an environmental sample or a fecal sample with high sensitivity.
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
85.
COPPER CHELATOR, ANTICANCER AGENT AND PROPHYLACTIC OR THERAPEUTIC AGENT FOR WILSON'S DISEASE
National University Corporation Hokkaido University (Japon)
Inventeur(s)
Takata, Masachika
Sunahara, Hirofumi
Wakimoto, Toshiyuki
Matsuda, Kenichi
Abrégé
A copper chelating agent that contains at least one compound selected from the group consisting of a compound represented by Formula (1), a compound represented by Formula (2), a compound represented by Formula (3), a compound represented by Formula (4), a salt thereof, and a solvate thereof:
A copper chelating agent that contains at least one compound selected from the group consisting of a compound represented by Formula (1), a compound represented by Formula (2), a compound represented by Formula (3), a compound represented by Formula (4), a salt thereof, and a solvate thereof:
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Osafune, Kenji
Mae, Shinichi
Nishio, Saori
Hattanda, Fumihiko
Abrégé
Provided is a pharmaceutical composition for treating and/or preventing renal cystic ciliopathy, the composition containing a retinoic acid receptor (RAR) agonist.
A61K 45/00 - Préparations médicinales contenant des ingrédients actifs non prévus dans les groupes
A61K 31/192 - Acides carboxyliques, p. ex. acide valproïque ayant des groupes aromatiques, p. ex. sulindac, acides 2-aryl-propioniques, acide éthacrynique
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Maenaka, Katsumi
Matsuda, Akira
Sawa, Hirofumi
Orba, Yasuko
Sasaki, Michihito
Uemura, Kentaro
Abrégé
[Problem] The present invention has as an object to provide an antiviral agent effective as a remedy for COVID-1 9 and other viral infections.
[Problem] The present invention has as an object to provide an antiviral agent effective as a remedy for COVID-1 9 and other viral infections.
[Resolution Means] Provided is an antiviral agent and the like, made of: the compound represented by general formula (1) or (2) below [R1 being —(CH2)n1—Z1—R11 2 r —CH—(—Z1—R11,)(n1 being 0 or 1; Z1 being a single bond, —O—, —NH—, —S—, —SO—, —SO2—,SO—CO—, —CO—O—, or —CH═N—O—; R11 being a hydrogen atom, an alkyl group having 1 to 6 carbons, —NR12 R13, —N3,—NO2,—CN, —CH2—CO—O—R14, or a five- or six-membered heterocyclic group including a nitrogen atom; R12 and R13 each independently being a hydrogen atom or an alkyl group having 1 to 6 carbons; and R14 being a hydrogen atom or an alkyl group having 1 to 6 carbons], a derivative thereof, a salt of these compounds, or a solvate thereof.
[Problem] The present invention has as an object to provide an antiviral agent effective as a remedy for COVID-1 9 and other viral infections.
[Resolution Means] Provided is an antiviral agent and the like, made of: the compound represented by general formula (1) or (2) below [R1 being —(CH2)n1—Z1—R11 2 r —CH—(—Z1—R11,)(n1 being 0 or 1; Z1 being a single bond, —O—, —NH—, —S—, —SO—, —SO2—,SO—CO—, —CO—O—, or —CH═N—O—; R11 being a hydrogen atom, an alkyl group having 1 to 6 carbons, —NR12 R13, —N3,—NO2,—CN, —CH2—CO—O—R14, or a five- or six-membered heterocyclic group including a nitrogen atom; R12 and R13 each independently being a hydrogen atom or an alkyl group having 1 to 6 carbons; and R14 being a hydrogen atom or an alkyl group having 1 to 6 carbons], a derivative thereof, a salt of these compounds, or a solvate thereof.
A61K 31/7064 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p. ex. nucléosides, nucléotides contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle contenant des pyrimidines condensées ou non-condensées
A61K 31/53 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec trois azote comme seuls hétéro-atomes d'un cycle, p. ex. chlorazanil, mélamine
A61K 31/685 - Diesters d'acide du phosphore avec deux composés hydroxyle, p. ex. phosphatidylinositols un des composés hydroxylés ayant des atomes d'azote, p. ex. phosphatidylsérine, lécithine
A61P 31/14 - Antiviraux pour le traitement des virus ARN
88.
PROTEIN MANUFACTURING METHOD, PLANT, AND PLANT VIRAL VECTOR PRODUCTION METHOD
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Nakahara Kenji
Masuta Chikara
Matsunaga Wataru
Suto Miyuki
Abrégé
This protein manufacturing method comprises a manufacturing step for causing a plant, having introduced therein a nucleic acid fragment encoding a target protein, to produce the target protein. The plant has the autophagy system thereof suppressed. The plant may be a plant in which the function of autophagy-related genes is suppressed or deficient, or a plant in which the expression of the autophagy-related genes is suppressed or lost. The autophagy-related genes preferably include at least one gene selected from the group consisting of ATG6 gene, ATG7 gene, ATG5 gene, and ATG8 gene.
A01H 1/00 - Procédés de modification des génotypes
A01H 5/00 - Angiospermes, c.-à-d. plantes à fleurs, caractérisées par leurs parties végétalesAngiospermes caractérisées autrement que par leur taxonomie botanique
A01H 6/82 - Solanaceae, p. ex. poivron, tabac, pomme de terre, tomate ou aubergine
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Igarashi Manabu
Kato Hiroki
Tsukamoto Yuta
Abrégé
Provided is a novel anti-influenza virus agent which inhibits the growth and infection mechanisms of influenza virus and thus has a target other than specific viral proteins and which does not cause the emergence of drug-resistant viruses. Also provided are a medicine, food, beverage, supplement, agricultural chemical, feed and cosmetic using the same. An anti-influenza virus composition containing, as an active ingredient, tubercidin, a tubercidin derivative or a salt thereof, and a medicine, food, beverage, supplement, agricultural chemical, feed and cosmetic using the same.
A61K 31/7064 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p. ex. nucléosides, nucléotides contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle contenant des pyrimidines condensées ou non-condensées
A01N 43/90 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant plusieurs hétérocycles déterminants condensés entre eux ou avec un système carbocyclique commun
A01P 1/00 - DésinfectantsComposés antimicrobiens ou leurs mélanges
A61K 8/69 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant du fluor
A61P 31/16 - Antiviraux pour le traitement des virus ARN de la grippe ou des rhinovirus
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
INTER-UNIVERSITY RESEARCH INSTITUTE CORPORATION HIGH ENERGY ACCELERATOR RESEARCH ORGANIZATION (Japon)
Inventeur(s)
Maenaka Katsumi
Fukuhara Hideo
Sawa Hirofumi
Suzuki Yasuhiko
Kita Shunsuke
Takasu Akira
Abrégé
This suction device is attached to a bottomed cylindrical container. The suction device comprises a suction part, a suction machine, a suction tube, and a filter. The suction part has a suction port and is attached to an opening of the container. The suction machine suctions air. The suction tube is connected to the suction part and the suction machine and communicates with the suction port, and air circulates through the suction tube. The filter is connected to the suction tube.
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY (Japon)
Inventeur(s)
Maeki Masatoshi
Tokeshi Manabu
Uno Shuya
Harashima Hideyoshi
Sato Yusuke
Kazuki Yasuhiro
Yamazaki Kyotaro
Abrégé
Provided are: a nucleic acid complex composition that has high efficiency for introducing nucleic acid molecules into cells and for diffusing the same within the cells and that can have high transfection efficiency; lipid particles for transfection; and a transfection method using the same. The present invention pertains to a nucleic acid complex composition, lipid particles for transfection, and a transfection method using the same. The nucleic acid complex composition contains nucleic acid molecules and a polycation having a structure formed through polymerization of cation molecules comprising a molecule chain including carbon atoms and nitrogen atoms.
C12N 15/88 - Introduction de matériel génétique étranger utilisant des procédés non prévus ailleurs, p. ex. co-transformation utilisant la micro-encapsulation, p. ex. utilisant des vésicules liposomiques
A61K 9/14 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres
A61K 31/7088 - Composés ayant au moins trois nucléosides ou nucléotides
A61K 47/34 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyesters, acides polyaminés, polysiloxanes, polyphosphazines, copolymères de polyalkylène glycol ou de poloxamères
National University Corporation Hokkaido University (Japon)
PuREC Co., Ltd. (Japon)
Mochida Pharmaceutical Co., Ltd. (Japon)
Inventeur(s)
Sudo, Hideki
Ukeba, Daisuke
Yamada, Katsuhisa
Ura, Katsuro
Suzuki, Hisataka
Iyoku, Yumi
Suyama, Takashi
Abrégé
Provided is a composition for promotion of the regeneration of the nucleus pulposus of an intervertebral disc, said composition comprising a low endotoxin monovalent metal salt of alginic acid and mesenchymal stem cells. In particular, the composition of the present invention promotes the regeneration of the nucleus pulposus of an intervertebral disc via activation of nucleus pulposus cells by human bone marrow-derived high-purity mesenchymal stem cells and/or differentiation of human bone marrow-derived high-purity mesenchymal stem cells into nucleus pulposus cells.
A61K 35/28 - Moelle osseuseCellules souches hématopoïétiquesCellules souches mésenchymateuses de toutes origines, p. ex. cellules souches dérivées de tissu adipeux
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 47/36 - PolysaccharidesLeurs dérivés, p. ex. gommes, amidon, alginate, dextrine, acide hyaluronique, chitosane, inuline, agar-agar ou pectine
A61P 19/02 - Médicaments pour le traitement des troubles du squelette des troubles articulaires, p. ex. arthrites, arthroses
93.
OCULAR FUNDUS IMAGE PROCESSING DEVICE AND OCULAR FUNDUS IMAGE PROCESSING PROGRAM
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Saito Michiyuki
Noda Kousuke
Fukutsu Kanae
Ishida Susumu
Abrégé
A control unit of this ocular fundus image processing device executes an ocular fundus image acquisition step, a blood vessel image acquisition step, and a probability map generation step. In the ocular fundus image acquisition step, the control unit acquires a plurality of ocular fundus images each including a blood vessel in the ocular fundus in an eye to be examined, which are captured by an ocular fundus image capture device. In the blood vessel image acquisition step, the control unit acquires a blood vessel image which shows at least one of an artery and a vein contained in each of the acquired ocular fundus images. In the probability map generation step, the control unit adds a plurality of blood vessel images respectively acquired for the plurality of ocular fundus images in an aligned state to generate a retinal blood vessel distribution probability map showing the distribution of existence probability of blood vessels present in the retina of the eye.
A61B 3/12 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux du type à mesure objective, c.-à-d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient pour examiner le fond de l'œil, p. ex. ophtalmoscopes
A61B 3/14 - Dispositions spécialement adaptées à la photographie de l'œil
G16H 30/00 - TIC spécialement adaptées au maniement ou au traitement d’images médicales
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
94.
RECEPTION DEVICE, QUANTUM KEY DISTRIBUTION SYSTEM, AND METHOD FOR DETECTING QUANTUM SIGNAL
NATIONAL INSTITUTE OF INFORMATION AND COMMUNICATIONS TECHNOLOGY (Japon)
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
THE UNIVERSITY OF TOKYO (Japon)
Inventeur(s)
Yoshino, Ken-Ichiro
Fujiwara, Mikio
Tomita, Akihisa
Koashi, Masato
Takeoka, Masahiro
Sasaki, Masahide
Abrégé
An object is to prevent eavesdropping in quantum key distribution. A decoding unit decodes a quantum signal incident thereinto. A plurality of detect photons of the decoded quantum signal output from the decoding unit. A signal processing unit detects bits of the decoded quantum signal based on photon detection results of the plurality of detectors. A control unit perform switching processing by switching destinations to which two decoded quantum signals corresponding to one encoding basis are output between the plurality of detectors, and switching the bits detected by the signal processing unit based on the respective photon detection results of the plurality of detectors.
G06N 10/40 - Réalisations ou architectures physiques de processeurs ou de composants quantiques pour la manipulation de qubits, p. ex. couplage ou commande de qubit
95.
Heat-resistant alloy, heat-resistant alloy powder, heat-resistant alloy structural component, and manufacturing method of the same
TOKYO METROPOLITAN PUBLIC UNIVERSITY CORPORATION (Japon)
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Kakehi, Koji
Hayashi, Shigenari
Kuo, Yen-Ling
Abrégé
A heat-resistant alloy contains Y, a content of Ni is a content of Ni is 58.0 mass % or greater, a content of Cr is 20.0 mass % or greater and 23.0 mass % or less, a content of Mo is 8.0 mass % or greater and 10.0 mass % or less, a content of Nb is 3.15 mass % or greater and 4.15 mass % or less, a content of O is 0.002 mass % or greater and 0.1 mass % or less, and a ratio of a content of Y in terms of mass to a content of O in terms of mass is 0.5 or greater and 100 or less.
C22C 19/05 - Alliages à base de nickel ou de cobalt, seuls ou ensemble à base de nickel avec du chrome
B22F 1/00 - Poudres métalliquesTraitement des poudres métalliques, p. ex. en vue de faciliter leur mise en œuvre ou d'améliorer leurs propriétés
B33Y 70/00 - Matériaux spécialement adaptés à la fabrication additive
C22C 1/04 - Fabrication des alliages non ferreux par métallurgie des poudres
C22F 1/10 - Modification de la structure physique des métaux ou alliages non ferreux par traitement thermique ou par travail à chaud ou à froid du nickel ou du cobalt ou de leurs alliages
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Katagiri Seiji
Tagami Takayoshi
Tanida Takashi
Abrégé
The present invention provides: a conception chance-improving composition for normalization of EGF concentration profile and conception chance improvement for a ruminant; and a method for improving ruminant conception chance using said composition. The present invention is: a ruminant conception chance-improving composition comprising, as an active ingredient, a peptide or polypeptide including the amino acid sequence represented by SEQ ID NO: 1; a ruminant conception chance-improving composition having, as an active ingredient, bovine osteopontin protein, a mutant of bovine osteopontin protein, or a partial peptide of these proteins, in which the protein, the mutant, and the partial peptide include the amino acid sequence represented by SEQ ID NO: 1; and a method for improving ruminant conception chance in which either of the conception chance-improving compositions is administered to the fornix vaginae, or the vicinity thereof, of the vaginal portion of a ruminant on an estrous day or the period immediately before/after such.
A61K 38/02 - Peptides à nombre indéterminé d'amino-acidesLeurs dérivés
A61P 15/08 - Médicaments pour le traitement des troubles génitaux ou sexuelsContraceptifs pour les troubles gonadiques ou pour augmenter la fertilité, p. ex. inducteurs d'ovulation ou de spermatogénèse
97.
RADIATION THERAPY SYSTEM, MOTION TRACKING DEVICE AND MOTION TRACKING METHOD
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Cheung, Ling Fung
Fujii, Takaaki
Fujitaka, Shinichiro
Miyamoto, Naoki
Umegaki, Kikuo
Miyazaki, Koichi
Abrégé
Provided is a feature for accurately irradiating a tumor with radiation. This motion tracking device has: a medical image extraction device for extracting, from a medical image of a patient, motion information which is information pertaining to the motion in a specific region of a target, tissue around the target, and a surrogate which is a pathognomic site; a motion model generator which constructs a motion model expressing the correlation between the motion of the target, the tissue and the surrogate on the basis of the motion information; a motion detector for measuring the motion of the surrogate during a treatment for irradiating the patient with therapeutic radiation; a motion estimator for estimating the current or future location of the target and tissue on the basis of the motion model and the motion of the surrogate; and a motion model corrector for correcting the estimated target and tissue location during treatment according to a pre-set correction protocol. The treatment control device subjects the patient to targeted therapeutic radiation on the basis of the estimated current or future location of the target and tissue.
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Konnai, Satoru
Maekawa, Naoya
Okagawa, Tomohiro
Ohashi, Kazuhiko
Murata, Shiro
Suzuki, Yasuhiko
Abrégé
Provided is a diagnostic antibody that is capable of detecting PD-L1 in tumors for novel therapies for feline tumors targeting PD-1/PD-L1. The anti-PD-L1 antibody contains: (a) an L-chain having CDR1 that has the amino acid sequence ESVDSYGNSF (SEQ ID NO: 1), CDR2 that has the amino acid sequence RAS, and CDR3 that has the amino acid sequence QQSNEDPRT (SEQ ID NO: 2); and (b) an H-chain having CDR1 that has the amino acid sequence GFTFSSYG (SEQ ID NO: 3), CDR2 that has the amino acid sequence ISNGGTYT (SEQ ID NO: 4), and CDR3 that has the amino acid sequence ARLGYGSLNWYFDV (SEQ ID NO: 5). A composition for detecting PD-L1 that contains the anti-PD-L1 antibody as an active ingredient. Also provided is a method for producing the anti-PD-L1 antibody.
C07K 14/705 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
C12N 1/15 - ChampignonsLeurs milieux de culture modifiés par l'introduction de matériel génétique étranger
C12N 1/19 - LevuresLeurs milieux de culture modifiés par l'introduction de matériel génétique étranger
C12N 1/21 - BactériesLeurs milieux de culture modifiés par l'introduction de matériel génétique étranger
C12N 5/10 - Cellules modifiées par l'introduction de matériel génétique étranger, p. ex. cellules transformées par des virus
C12N 15/12 - Gènes codant pour des protéines animales
C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteursVecteurs Utilisation d'hôtes pour ceux-ciRégulation de l'expression
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Yonezawa, Tetsu
Tsukamoto, Hiroki
Abrégé
64822O; and mixing the raw material particle with a solution containing an amine-based compound and a complex forming agent, and then adding a reductant to the resultant to allow a reaction in an oxygen-containing atmosphere.
B22F 1/00 - Poudres métalliquesTraitement des poudres métalliques, p. ex. en vue de faciliter leur mise en œuvre ou d'améliorer leurs propriétés
B22F 1/16 - Particules métalliques revêtues d'un non-métal
B22F 7/08 - Fabrication de couches composites, de pièces ou d'objets à base de poudres métalliques, par frittage avec ou sans compactage de pièces ou objets composés de parties différentes, p. ex. pour former des outils à embouts rapportés avec une ou plusieurs parties non faites à partir de poudre
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japon)
Inventeur(s)
Nakamura, Takashi
Harashima, Hideyoshi
Sato, Yusuke
Yamada, Koharu
Nakade, Taisei
Abrégé
The present invention provides a lipid nanoparticle and the like containing a pH-sensitive cationic lipid represented by formula (1) (in formula (1), R1 and R2 are each independently a straight-chain C10-14 alkyl group, a straight-chain C10-20 alkenyl group having one or two unsaturated bonds, or —CH(R5)(R6)(where R5 and R6 are each independently a straight-chain C5-10 alkyl group); p represents an integer of 3-8; and R3 and R4 are each independently a methyl group or an ethyl group].
The present invention provides a lipid nanoparticle and the like containing a pH-sensitive cationic lipid represented by formula (1) (in formula (1), R1 and R2 are each independently a straight-chain C10-14 alkyl group, a straight-chain C10-20 alkenyl group having one or two unsaturated bonds, or —CH(R5)(R6)(where R5 and R6 are each independently a straight-chain C5-10 alkyl group); p represents an integer of 3-8; and R3 and R4 are each independently a methyl group or an ethyl group].
A61K 35/17 - LymphocytesLymphocytes BLymphocytes TCellules tueuses naturellesLymphocytes activés par un interféron ou une cytokine
C12N 5/0783 - Cellules TCellules NKProgéniteurs de cellules T ou NK
A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
A61K 31/7105 - Acides ribonucléiques naturels, c.-à-d. contenant uniquement des riboses liés à l'adénine, la guanine, la cytosine ou l'uracile et ayant des liaisons 3'-5' phosphodiester