POLYPEPTIDE PERMEABLE THROUGH OUTER MEMBRANE OF GRAM-NEGATIVE BACTERIUM, ANTIBACTERIAL PROTEIN COMPRISING SAID POLYPEPTIDE, ANTIBACTERIAL AGENT OR DISINFECTANT, PHARMACEUTICAL COMPOSITION, AND ANTIBACTERIAL AGENT COMPOSITION OR DISINFECTANT COMPOSITION
NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY (Japon)
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Uchiyama, Jumpei
Uchiyama, Iyo
Fukuda, Ken
Yamashiro, Kenji
Abrégé
Provided are: a polypeptide of any one of the following items (i) to (iii); an antibacterial protein comprising the polypeptide; an antibacterial agent; a disinfectant; a pharmaceutical composition; an antibacterial agent composition; and a disinfectant composition. (i) A polypeptide comprising the amino acid sequence represented by SEQ ID NO:1; (ii) a polypeptide comprising an amino acid sequence having a structure such that one or several amino acid residues are deleted, substituted, inserted and/or added in the amino acid sequence represented by SEQ ID NO:1; or (iii) a polypeptide comprising an amino acid sequence having sequence identity of 80% or higher with the amino acid sequence represented by SEQ ID NO:1.
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Namba, Takushi
Onda, Ayumu
Abrégé
The purpose of the present invention is to provide a preparation capable of effectively ameliorating organ disorder. The organ disorder amelioration agent according to the present invention is characterized by containing, as an active ingredient, an H-type ulvan or an alkali metal ion salt of ulvan.
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Onari, Toma
Ashiuchi, Makoto
Hakumai, Yuichi
Tanaka, Takanori
Abrégé
The purpose of the present invention is to provide: a novel ion complex which has excellent ability to trap fine particles and functions to inhibit pollen from rupturing; a dispersion containing the novel ion complex; and a filter for trapping fine particles, the filter including a coating layer containing the novel ion complex as an active ingredient. This ion complex is characterized by comprising an anionic polymer and a quaternary ammonium ion compound represented by formula (I). [In the formula, R1and R24-204-20 alkyl group, and R3and R41-24-204-20 alkyl group.]
A01N 61/00 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des substances de composition non connue ou indéterminée, p. ex. des substances caractérisées uniquement par leur mode d'action
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
NATIONAL UNIVERSITY CORPORATION EHIME UNIVERSITY (Japon)
Inventeur(s)
Niko,yosuke
Touchi,yuki
Hashimoto,takuya
Yamamoto,riko
Murakami,masamoto
Kawakami,ryosuke
Tsuda,teruko
Imamura,takeshi
Abrégé
[Problem] The purpose of the present invention is to provide: a compound that can be suitably used in a fluorescent dye or the like; a novel fluorescent dye and a kit for conveniently detecting cells; a novel method for conveniently detecting cells; and a dyeing material or the like. [Solution] A compound represented by formula (1) or a salt thereof. (In formula (1), R1 is an alkyl group having 1-12 carbon atoms, an alkenyl group having 2-12 carbon atoms, an alkynyl group having 2-12 carbon atoms, or the like, all of the foregoing being substituted or unsubstituted.)
C07C 229/18 - Composés contenant des groupes amino et carboxyle liés au même squelette carboné ayant des groupes amino et carboxyle liés à des atomes de carbone acycliques du même squelette carboné le squelette carboné étant acyclique et saturé ayant un seul groupe amino et un seul groupe carboxyle liés au squelette carboné l'atome d'azote du groupe amino étant lié de plus à des atomes de carbone de cycles aromatiques à six chaînons
C07D 295/112 - Composés hétérocycliques contenant des cycles polyméthylène imine d'au moins cinq chaînons, des cycles aza-3 bicyclo [3.2.2] nonane, piperazine, morpholine ou thiomorpholine, ne comportant que des atomes d'hydrogène liés directement aux atomes de carbone du cycle avec des radicaux hydrocarbonés substitués liés aux atomes d'azote du cycle substitués par des atomes d'oxygène ou de soufre liés par des liaisons doubles avec les atomes d'azote du cycle et les atomes d'oxygène ou de soufre liés par des liaisons doubles séparés par des carbocycles ou par des chaînes carbonées interrompues par des carbocycles
C07D 295/155 - Composés hétérocycliques contenant des cycles polyméthylène imine d'au moins cinq chaînons, des cycles aza-3 bicyclo [3.2.2] nonane, piperazine, morpholine ou thiomorpholine, ne comportant que des atomes d'hydrogène liés directement aux atomes de carbone du cycle avec des radicaux hydrocarbonés substitués liés aux atomes d'azote du cycle substitués par des atomes de carbone comportant trois liaisons à des hétéro-atomes avec au plus une liaison à un halogène, p. ex. radicaux ester ou nitrile avec les atomes d'azote du cycle et les atomes de carbone comportant trois liaisons à des hétéro-atomes séparés par des carbocycles ou par des chaînes carbonées interrompues par des carbocycles
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
NIREC CORPORATION (Japon)
Inventeur(s)
Sato Takayuki
Sumida Tetsuo
Abrégé
With respect to an insertion tool to be inserted into a natural opening in a body, e.g., the vagina and rectum, the purpose of the present invention is to allow light to efficiently and safely enter a tissue in a body cavity from the distal end of the insertion tool in the state where the insertion tool has been inserted into the body, and to enable satisfactory observation of light, which enters the tissue in the body cavity from the distal end, from the abdominal cavity side. An insertion tool 1A to be inserted into a natural opening in a body is provided with a light source 10 at the proximal end of a cylindrical body 2 formed from a light-conductive resin, and is also provided with a light-emitting section at the distal end thereof. The light-emitting section located at the distal end has a structure such that light entering the proximal end is injected at high intensity from the light-emitting section located at the distal end toward the radial outside of the cylindrical body 2. An example of the light-emitting section located at the distal end is an annular convex part 20A that is convex toward the radial outside of the cylindrical body 2 and has a curved surface 21 that is closely adhered to a tissue in a body cavity.
A61B 17/42 - Instruments ou procédés de gynécologie ou d'obstétrique
A61B 90/30 - Dispositifs pour éclairer une zone chirurgicale, les dispositifs ayant une corrélation avec d’autres dispositifs chirurgicaux ou avec une intervention chirurgicale
6.
COMPOUND, FLUORESCENT DYE, KIT, AND METHOD FOR DETECTING CELLS
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
NATIONAL UNIVERSITY CORPORATION EHIME UNIVERSITY (Japon)
Inventeur(s)
Niko, Yosuke
Inoue, Kazuki
Nakayama, Taku
Hadano, Shingo
Watanabe, Shigeru
Murakami, Masamoto
Kawakami, Ryosuke
Tsuda, Teruko
Sayama, Koji
Imamura, Takeshi
Abrégé
The present invention aims at providing a compound that can be suitably used as a fluorescent dye or the like, a novel fluorescent dye and kit for easily detecting cells, a novel method for easily detecting cells or the like, and so on. A compound represented by the following formula (1) or a salt thereof:
The present invention aims at providing a compound that can be suitably used as a fluorescent dye or the like, a novel fluorescent dye and kit for easily detecting cells, a novel method for easily detecting cells or the like, and so on. A compound represented by the following formula (1) or a salt thereof:
in the formula (1),
R1 is a substituted or unsubstituted alkyl group having 1 to 12 carbon atoms or the like;
R2 and R3 are each independently a substituted or unsubstituted alkyl group having 1 to 6 carbon atoms or the like;
R4 and R5 are each independently an alkyl group having 1 to 12 carbon atoms or the like;
n is an integer of 1 to 4; and
a and b are each independently an integer of 0 to 4.
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Onda, Ayumu
Namba, Takushi
Abrégé
The purpose of the present invention is to provide an anti-aging agent which exhibits an excellent effect such as a mitochondria activating effect. The anti-aging agent according to the present invention is characterized by containing an H-type ulvan or an alkali metal ion salt of ulvan as an active ingredient.
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
SHIONOGI & CO., LTD. (Japon)
Inventeur(s)
Aoyama, Bun
Kawano, Takashi
Abrégé
The purpose of the present invention is to provide a preparation that can effectively suppress post-operative delirium. A post-operative delirium suppressant according to the present invention is characterized by containing a GABA-A receptor selective positive allosteric modulator as an active ingredient.
A61K 45/00 - Préparations médicinales contenant des ingrédients actifs non prévus dans les groupes
A61K 31/568 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes non substitués en position 17 bêta par un atome de carbone, p. ex. œstrane, œstradiol substitués en positions 10 et 13 par une chaîne ayant au moins un atome de carbone, p. ex. androstane, testostérone
A61K 31/57 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone
A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone substitués en position 21, p. ex. cortisone, dexaméthasone, prednisone ou aldostérone
A61K 31/575 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne d'au moins trois atomes de carbone, p. ex. cholane, cholestane, ergostérol, sitostérol
A61K 31/58 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes contenant des hétérocycles, p. ex. danazol, stanozolol, pancuronium ou digitogénine
A61P 25/02 - Médicaments pour le traitement des troubles du système nerveux des neuropathies périphériques
A61P 25/18 - Antipsychotiques, c.-à-d. neuroleptiquesMédicaments pour le traitement de la manie ou de la schizophrénie
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes
9.
ECO-FRIENDLY PLASTIC, ECO-FRIENDLY PLASTIC FIBER, AND PGA ION COMPLEX
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
MORIRIN CO., LTD. (Japon)
Inventeur(s)
Ashiuchi, Makoto
Hakumai, Yuichi
Onari, Toma
Kosaki, Masahiro
Hashida, Yoshimasa
Abrégé
An eco-friendly plastic and an eco-friendly plastic fiber according to the present invention contain: a polymeric compound having low microbial decomposability; and a poly-γ-glutamic acid (PGA), or a salt thereof, contained in the polymeric compound. The PGA may be used in the form of a PGA ion complex. The PGA ion complex according to the present invention comprises a poly-γ-glutamic acid (PGA), and a polyvalent metallic ion that is trivalent or higher.
C08L 67/00 - Compositions contenant des polyesters obtenus par des réactions créant une liaison ester carboxylique dans la chaîne principaleCompositions contenant des dérivés de tels polymères
C08L 77/04 - Polyamides dérivés des acides alpha-aminocarboxyliques
D01F 6/92 - Filaments, ou similaires, faits par l’homme, à un seul composant, formés de polymères synthétiquesLeur fabrication à partir de mélanges de produits de polycondensation comme constituant majeur avec d'autres polymères ou des composés de bas poids moléculaire de polyesters
10.
NOVEL BACTERIOPHAGE AND THERAPEUTIC AGENT FOR BACTERIAL ENDOPHTHALMITIS
National University Corporation Kochi University (Japon)
Inventeur(s)
Fukuda, Ken
Matsuzaki, Shigenobu
Fukushima, Atsuki
Daibata, Masanori
Uchiyama, Jumpei
Abrégé
The objective of the present invention is to provide a novel bacteriophage useful for treating bacterial endophthalmitis and a therapeutic agent for bacterial endophthalmitis comprising the novel bacteriophage. The therapeutic agent for bacterial endophthalmitis according to the present invention is characterized in comprising 1 or more bacteriophages selected from the group essentially consisting of Myoviridae Spounavirinae phiEF7H (accession number: NITE BP-02886), Myoviridae Spounavirinae phiEF19G (accession number: NITE BP-02887), Myoviridae Spounavirinae phiEF14H1 (accession number: NITE BP-02888), and mutants thereof.
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Yamashita, Tatsuyuki
Honke, Koichi
Abrégé
The present invention provides a production method of an extracellular vesicle population containing extracellular vesicles on the membrane surface of which phosphatidylserine is low expressed, said method comprising: (1) a step for culturing mesenchymal stem cells in a medium containing one or more sulfuric acid compounds selected from the group consisting of a sulfated glycolipid, cholesterol sulfate and pharmaceutically acceptable salts thereof; and (2) a step for collecting an extracellular vesicle population contained in the medium after carrying out the above step (1). The present invention also provides an extracellular vesicle population containing extracellular vesicles on the membrane surface of which phosphatidylserine is low expressed.
A61K 35/12 - Substances provenant de mammifèresCompositions comprenant des tissus ou des cellules non spécifiésCompositions comprenant des cellules souches non embryonnairesCellules génétiquement modifiées
A61K 35/28 - Moelle osseuseCellules souches hématopoïétiquesCellules souches mésenchymateuses de toutes origines, p. ex. cellules souches dérivées de tissu adipeux
A61P 9/10 - Médicaments pour le traitement des troubles du système cardiovasculaire des maladies ischémiques ou athéroscléreuses, p. ex. médicaments antiangineux, vasodilatateurs coronariens, médicaments pour le traitement de l'infarctus du myocarde, de la rétinopathie, de l'insuffisance cérébro-vasculaire, de l'artériosclérose rénale
A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
C12N 5/071 - Cellules ou tissus de vertébrés, p. ex. cellules humaines ou tissus humains
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
NIREC CORPORATION (Japon)
Inventeur(s)
Sato, Takayuki
Sumida, Tetsuo
Abrégé
A living body compressing clip 100 includes a clip body 1 with metallic arm parts 5a and 5b configured to hold a living body tissue. The clip body 1 includes compressing pieces 10 that protrude from distal end parts of the arm parts 5a and 5b in a long-side direction of the arm parts 5a and 5b. The compressing pieces 10 are formed from a flexible resin and hold a fluorescent dye. According to the living body compressing clip 100, the compressing pieces 10 causes a vascular network to collapse while holding the living body tissue by the arm parts 5a and 5b. Therefore, when the arm parts 5a and 5b hold the mucosal tissue of the tubular organ and excitation light is applied thereto, the fluorescence emitted by the compressing pieces 10 can be satisfactorily confirmed from the serosal side.
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
A61B 17/122 - Clamps ou pinces, p. ex. pour le cordon ombilical
A61B 17/128 - Instruments, dispositifs ou procédés chirurgicaux pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p. ex. les vaisseaux sanguins ou le cordon ombilical pour appliquer ou enlever les clamps ou les pinces
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Namba, Takushi
Oki, Shoma
Abrégé
The purpose of the present invention is to provide an anti-lifestyle disease agent which is safer and has an anti-obesity activity, an activity of improving insulin resistance, an activity of lowering blood sugar level, an activity of lowering blood lipid level, and the like. The anti-lifestyle disease agent is characterized by containing a compound represented by Formula (I) or a salt thereof as an active ingredient. R12222R2... (I) (In the formula, R1and R21-61-6 alkyl group.)
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Naka, Tetsuji
Serada, Satoshi
Abrégé
The present disclosure provides a humanized antibody that specifically binds to Glypican-1 (GPC-1), and also provides technologies, methods, medicines, and the like related to the humanized antibody. In one aspect, the present disclosure provides a humanized anti-GPC-1 monoclonal antibody that has a high affinity for GPC-1 and has high internalization activity in GPC-1-positive cells. In another aspect, the present disclosure also provides a composition for preventing or treating Glypican-1-positive cancer that includes a complex of a humanized anti-GPC-1 monoclonal antibody and a medicine having cytotoxic activity.
C07K 16/30 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire provenant de cellules de tumeurs
A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p. ex. un fragment Fc
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A61P 1/18 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des troubles pancréatiques, p. ex. enzymes pancréatiques
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Sagara, Yusuke
Abrégé
Provided is a cranial neuropathy therapeutic agent that contains, as an active ingredient, a culture supernatant for umbilical cord blood monocytic cells.
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
16.
CRANIAL NERVE DISORDER THERAPEUTIC AGENT INCLUDING CULTURE SUPERNATANT OF TISSUE CELLS DERIVED FROM FETAL APPENDAGE
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Sagara, Yusuke
Abrégé
Provided is a cranial nerve disorder therapeutic agent that includes, as an active ingredient, a culture supernatant of tissue cells derived from a fetal appendage.
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
SPECTRO DECYPHER, INC. (Japon)
Inventeur(s)
Tsuda, Masashi
Tsuda, Masayuki
Nakayama, Noboru
Nakaoka, Shigeru
Abrégé
A subject S to which 17O gas has been administered is placed within a fixed uniform static magnetic field of an NMR apparatus 1. The subject is irradiated, through proton coupling, with an excitation pulse produced using a pulse sequence having a short cycle time of 20.4 msec or less, preferably 10.4 msec or less, and more preferably 5.6 msec or less. An NMR signal generated due to 17O nuclei of 17O water produced within the subject by oxygen metabolism of the 17O gas being excited by irradiation with the excitation pulse is detected with high sensitivity and is processed in accordance with a prescribed imaging sequence in which an MRS sequence is used.
G01R 33/44 - Dispositions ou appareils pour la mesure des grandeurs magnétiques faisant intervenir la résonance magnétique utilisant la résonance magnétique nucléaire [RMN]
G01R 33/54 - Systèmes de traitement du signal, p. ex. utilisant des séquences d'impulsions
G01R 33/485 - Systèmes d'imagerie RMN avec sélection de signaux ou de spectres de régions particulières du volume, p. ex. spectroscopie in vivo basés sur l'information de déplacement chimique
A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
18.
MARKER FOR PANCREATIC CANCER AND INTRADUCTAL PAPILLARY MUCINOUS NEOPLASMS
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Taniuchi, Keisuke
Abrégé
A marker having excellent sensitivity and specificity to pancreatic cancer and intraductal papillary mucinous neoplasms. Also, a kit for diagnosing pancreatic cancer and intraductal papillary mucinous neoplasms to detect the marker, and a method for evaluating a metastasis of a pancreas cancer cell by using the marker. The marker for pancreatic cancer and intraductal papillary mucinous neoplasms according to the present invention comprises one or more proteins selected from the group essentially consisting of secretoglobin, family 1D, member 2 and podocalyxin-like protein. The kit for diagnosing pancreatic cancer and intraductal papillary mucinous neoplasms according comprises an antibody to one or more proteins selected from the group essentially consisting of secretoglobin, family 1D, member 2 and podocalyxin-like protein.
C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
C07K 16/30 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire provenant de cellules de tumeurs
19.
SEPARATION METHOD, SEPARATION AND PURIFICATION METHOD AND METHOD FOR PRODUCING RADIOISOTOPE, AND SEPARATION APPARATUS, SEPARATION AND PURIFICATION SYSTEM, AND ACCUMULATION DEVICE FOR SEPARATION AND PURIFICATION
NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY (Japon)
NATIONAL INSTITUTES FOR QUANTUM SCIENCE AND TECHNOLOGY (Japon)
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Ohira Shin-Ichi
Toda Kei
Sugo Yumi
Mori Masanobu
Abrégé
Provided is a separation and purification method comprising: a step (1) for adjusting a sample solution including a first metal ion, a second metal ion, and a chelating agent to a pH at which the second metal ion chelates to form a complex having a negative charge, while the first metal ion essentially does not chelate; a step (2-1) for bringing a solution containing the first metal ion and the chelated second metal ion obtained in step (1) into contact with a cation exchange body, and adsorbing the first metal ion in the solution on the cation exchange body to remove the first metal ion; a step (2-2) for obtaining a treated solution containing the chelated second metal ion, from which the first metal ion has been removed; and a step (3) for decomposing the chelating agent for the chelated second metal ion contained in the treated solution obtained in step (2-2), to obtain a purified second metal ion. This separation and purification method is suitable when the second metal is a radioisotope obtained by conversion from the first metal.
G21G 4/08 - Sources radioactives autres que les sources de neutrons caractérisées par des aspects de leur structure spécialement adaptées aux applications médicales
C22B 3/24 - Traitement ou purification de solutions, p. ex. de solutions obtenues par lixiviation par des procédés physiques, p. ex. par filtration, par des moyens magnétiques par adsorption sur des substances solides, p. ex. par extraction avec des résines solides
B01J 39/05 - Procédés utilisant des échangeurs organiques sous forme fortement acide
B01J 39/07 - Procédés utilisant des échangeurs organiques sous forme faiblement acide
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Takada, Naoki
Oda, Yoshihiro
Suzuki, Kohei
Moriguchi, Yoshiki
Yamasaki, Takashi
Mitani, Towa
Uchida, Junai
Abrégé
Provided is an aerial projection device that can display an image in midair by using an image display means having a simple structure. This aerial projection device 10 is configured from: a holographic projector unit 10a that emits diffracted light which is illuminated collimated light diffracted on the basis of interference information regarding a hologram of a cube which is a prescribed image; and a projection unit 10b that comprises a stereoscopic screen 28 onto which the diffracted light is illuminated such that the cube is projected thereon, a second half-silvered mirror 30 which is disposed at an angle relative to the diffracted light illuminated onto the stereoscopic screen 28 at a location illuminated by transmitted-diffused light of the diffracted light that has been transmitted through and diffused by the screen, and a retroreflective sheet 32 which is illuminated by light transmitted through the second half-silvered mirror 30, wherein a real image 34 of the cube is formed in midair by reflected light, which is obtained by the light transmitted through the second half-silvered mirror 30, of the transmitted-diffused light, being reflected by the retroreflective sheet 32, emitted in the opposite direction along the original incidence path, and reflected by the second half-silvered mirror 30.
G02B 30/56 - Systèmes ou appareils optiques pour produire des effets tridimensionnels [3D], p. ex. des effets stéréoscopiques l’image étant construite à partir d'éléments d'image répartis sur un volume 3D, p. ex. des voxels en projetant une image aérienne ou flottante
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
TOKYO UNIVERSITY OF SCIENCE FOUNDATION (Japon)
Inventeur(s)
Taniuchi, Keisuke
Wada, Takeshi
Hara, Rintaro
Sato, Kazuki
Takagi, Kazunori
Abrégé
A novel anti-tumor agent capable of delivering siRNA or shRNA specifically to pancreatic cancer cells and suppressing tumor growth, invasion, and metastasis of pancreatic cancer is provided. The present invention provides a nucleic acid delivery enhancer for delivering siRNA or shRNA into cells, which consists of a folic acid-cationic oligopeptide complex. The present invention also provides an anti-tumor agent having siRNA or shRNA capable of binding to mRNA or snoRNA expressed in pancreatic cancer cells to inhibit its expression and a folic acid-cationic oligopeptide complex. The siRNA is capable of binding to RNA selected from the group consisting of, for example, SNORA18 snoRNA, NUP85 mRNA, WASF2 mRNA, and SNORA22 snoRNA.
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Ikeue, Yasunori
Nagataki, Mitsuru
Nagata, Shinji
Abrégé
The purpose of the present invention is to provide: a method for producing novel β-1,3-1,6-glucan exhibiting an excellent anticancer action; novel black yeast-like bacteria used in said production method; and novel β-1,3-1,6-glucan exhibiting an excellent anticancer action. A method for producing β-1,3-1,6-glucan according to the present invention is characterized by comprising a step for culturing an Aureobasidium pullulans APNN-M163 strain (accession number: NITE BP-03377) in a culture medium.
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
NATIONAL UNIVERSITY CORPORATION EHIME UNIVERSITY (Japon)
Inventeur(s)
Niko,yosuke
Inoue,kazuki
Nakayama,taku
Hadano,shingo
Watanabe,shigeru
Murakami,masamoto
Kawakami,ryosuke
Tsuda,teruko
Sayama,koji
Imamura,takeshi
Abrégé
The purpose of the present invention is to provide a compound that can be suitably used in a fluorochrome or similar, a novel fluorochrome and kit for conveniently detecting cells, and a novel method for conveniently detecting cells or similar. A compound represented by formula (1) or a salt thereof. (In formula (1), R1is a substituted or unsubstituted C1-12 alkyl group or similar, R2and R3are each independently a substituted or unsubstituted C1-6 alkyl group or similar, R4and R5 are each independently a C1-12 alkyl group or similar, n is an integer from 1 to 4, and a and b are each independently an integer from 0 to 4.)
C07D 295/112 - Composés hétérocycliques contenant des cycles polyméthylène imine d'au moins cinq chaînons, des cycles aza-3 bicyclo [3.2.2] nonane, piperazine, morpholine ou thiomorpholine, ne comportant que des atomes d'hydrogène liés directement aux atomes de carbone du cycle avec des radicaux hydrocarbonés substitués liés aux atomes d'azote du cycle substitués par des atomes d'oxygène ou de soufre liés par des liaisons doubles avec les atomes d'azote du cycle et les atomes d'oxygène ou de soufre liés par des liaisons doubles séparés par des carbocycles ou par des chaînes carbonées interrompues par des carbocycles
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Ashiuchi, Makoto
Hakumai, Yuichi
Onari, Toma
Abrégé
The purpose of the present invention is to provide an adhesive agent which is safe and has low environmental impact, and an adhering method which uses the adhesive agent. An adhesive agent according to the present invention is characterized by comprising, as active components, poly-γ-glutamic acid and a specific pyridinium compound. A method according to the present invention for adhering two adhesion targets is characterized by comprising: a step for either softening the adhesive agent according to the present invention on the surface of at least one of the adhesion targets, or adhering, onto the surface of at least one of the adhesion targets, the adhesive agent according to the present invention which has been softened; and a step for press-bonding, onto the softened adhesive agent on the surface of one of the adhesion targets, the other one of the adhesion targets.
JAPAN AGENCY FOR MARINE-EARTH SCIENCE AND TECHNOLOGY (Japon)
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Morono Yuki
Uramoto Goichiro
Abrégé
Provided is a method for visualizing gaps in a sample whereby it is possible to distinguish between water and organic matter that both have a low X-ray absorption rate. The method for visualizing gaps in a sample involves the use of X-ray CT and includes a step in which an indicator obtained by filling the gaps in a sample with an ionic liquid containing a component with high X-ray absorption properties is prepared, the prepared indicator is irradiated with X-rays, X-rays that pass through the indicator are detected, and an image of the indicator in which the contrast is enhanced between gap locations and other locations is obtained.
G01N 23/046 - Recherche ou analyse des matériaux par l'utilisation de rayonnement [ondes ou particules], p. ex. rayons X ou neutrons, non couvertes par les groupes , ou en transmettant la radiation à travers le matériau et formant des images des matériaux en utilisant la tomographie, p. ex. la tomographie informatisée
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
NIREC CORPORATION (Japon)
Inventeur(s)
Sato Takayuki
Sumida Tetsuo
Abrégé
This living body compression clip 100 is equipped with a clip body 1 having metal arm parts 5a, 5b that pinch a living body tissue. The clip body 1 has compression pieces 10 that protrude from the distal end sections of the arm parts 5a, 5b in the longitudinal direction of the arm parts 5a, 5b. The compression pieces 10 are formed from a flexible resin and hold a fluorescent dye. According to this living body compression clip 100, the compression pieces 10 collapse the vascular network while the arm parts 5a, 5b pinch the living body tissue. Therefore, when the mucosal tissue of a hollow organ is pinched by the arm parts 5a, 5b and irradiated with excitation light, the fluorescence emitted by the compression pieces 10 can be confirmed successfully from the serosa side.
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Sato, Takayuki
Katahira, Haruyasu
Sumida, Tetsuo
Kanayama, Shigehiro
Abrégé
An endoscope includes a scope and an image capturing unit accommodated inside the scope. The image capturing unit includes: first and second prisms; a reflection film provided between oblique faces of the first and second prisms; a first trimming filter on which visible light transmitted through the first prism is incident on the first trimming filter via the reflection film; a first image sensor facing the first trimming filter; a second trimming filter on which near-infrared light transmitted through the second prism being incident on the second trimming filter via the reflection film; and a second image sensor facing the second trimming filter. The first prism is fixed to the second prism, the first trimming filter is fixed to the first prism, and the second trimming filter is fixed to the second prism.
A61B 1/00 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments
A61B 1/05 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments combinés avec des dispositifs photographiques ou de télévision caractérisés par le fait que le capteur d'images, p. ex. l'appareil photographique, est placé dans la partie de l'extrémité distale
H04N 5/238 - Circuits pour la compensation des variations de la luminance de l'objet en agissant sur la partie optique de la caméra
G02B 23/24 - Instruments pour regarder l'intérieur de corps creux, p. ex. endoscopes à fibres
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Sato, Takayuki
Abrégé
An openable and closable clip for medical use includes a resin clip body, and a fastening ring to be fitted onto the clip body. Clip body includes a pair of opposing arm parts, and connecting part that connects base ends of respective arm parts. Each arm part includes curved part on a base end side, holding part on distal end side, and intermediate part between curved and holding parts. Curved part is curved in arc shape, and intermediate part has a thickness greater than that of curved part. Clip body closes in state where fastening ring is fitted onto clip body on side closer to connecting part than curved part, opens when fastening ring slides onto curved part from connecting part, and closes when fastening ring slides onto intermediate part from curved part. Openable and closable clip can be used in endoscope clip device and opens and closes stably.
A61B 17/122 - Clamps ou pinces, p. ex. pour le cordon ombilical
A61B 17/12 - Instruments, dispositifs ou procédés chirurgicaux pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p. ex. les vaisseaux sanguins ou le cordon ombilical
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
29.
FLUORESCENT DYE AND METHOD FOR DETECTING TUMOR CELLS
NATIONAL UNIVERSITY CORPORATION EHIME UNIVERSITY (Japon)
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Murakami,masamoto
Kawakami,ryosuke
Tsuda,teruko
Sayama,koji
Imamura,takeshi
Niko,yosuke
Inoue,kazuki
Nakayama,taku
Hadano,shingo
Watanabe,shigeru
Abrégé
The present invention relates to providing a new method for easily detecting tumor cells in tissue from a living body. The present invention includes a fluorescent dye containing a compound that exhibits solvatochromism for detecting tumor cells in tissue. The present invention also includes a method for staining tissue derived from a living body or applying to a living body the fluorescent dye to detect tumor cells or specify the range of tumor removal.
C09K 11/06 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances organiques luminescentes
C07D 295/112 - Composés hétérocycliques contenant des cycles polyméthylène imine d'au moins cinq chaînons, des cycles aza-3 bicyclo [3.2.2] nonane, piperazine, morpholine ou thiomorpholine, ne comportant que des atomes d'hydrogène liés directement aux atomes de carbone du cycle avec des radicaux hydrocarbonés substitués liés aux atomes d'azote du cycle substitués par des atomes d'oxygène ou de soufre liés par des liaisons doubles avec les atomes d'azote du cycle et les atomes d'oxygène ou de soufre liés par des liaisons doubles séparés par des carbocycles ou par des chaînes carbonées interrompues par des carbocycles
C09B 57/00 - Autres colorants synthétiques de structure connue
C09B 67/20 - Préparations à base de pigments organiques
NATIONAL UNIVERSITY CORPORATION EHIME UNIVERSITY (Japon)
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Murakami, Masamoto
Kawakami, Ryosuke
Tsuda, Teruko
Sayama, Koji
Imamura, Takeshi
Niko, Yosuke
Inoue, Kazuki
Nakayama, Taku
Hadano, Shingo
Watanabe, Shigeru
Abrégé
The present invention relates to providing a novel method for easily detecting tumor cells in a tissue derived from an organism. The present invention includes a fluorescent dye for detecting tumor cells in a tissue, including a compound that exhibits solvatochromism. The present invention also includes a method for detecting tumor cells or specifying a tumor removal area, including applying the fluorescent dye to staining of a tissue derived from an organism and to an organism.
C07D 295/112 - Composés hétérocycliques contenant des cycles polyméthylène imine d'au moins cinq chaînons, des cycles aza-3 bicyclo [3.2.2] nonane, piperazine, morpholine ou thiomorpholine, ne comportant que des atomes d'hydrogène liés directement aux atomes de carbone du cycle avec des radicaux hydrocarbonés substitués liés aux atomes d'azote du cycle substitués par des atomes d'oxygène ou de soufre liés par des liaisons doubles avec les atomes d'azote du cycle et les atomes d'oxygène ou de soufre liés par des liaisons doubles séparés par des carbocycles ou par des chaînes carbonées interrompues par des carbocycles
C09B 57/00 - Autres colorants synthétiques de structure connue
C09B 67/20 - Préparations à base de pigments organiques
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Sato, Takayuki
Abrégé
A medical tool for fingertip of the present invention has a resin layer that emits red fluorescence or near-infrared fluorescence, and is used by putting it on a fingertip. More specifically, the medical tools for fingertip 1A to 1E have a finger cot shape and an opening portion 2 from which the ball of the finger is exposed when put on, and are formed of a resin that emits red fluorescence or near-infrared fluorescence. Alternatively, the medical tools for fingertip 1F and 1G have a glove shape, and a printing layer 8, 9 that is formed of a resin that emits red fluorescence or near-infrared fluorescence on or around the ball of the finger thereof. Further alternatively, the medical tools for fingertip 1H and 1I are a sticker-like medical tool having an adhesive layer provided to one surface of the resin layer that emits red fluorescence or near-infrared fluorescence, and have a size that allows it to be attached to the ball of the finger. When the medical tools for fingertip are put on the tip of a finger of a surgeon used for palpation of a living body, the position of an affected site which has been specified from the mucosal side by the palpation can be accurately specified from the serosal side.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
A61B 90/30 - Dispositifs pour éclairer une zone chirurgicale, les dispositifs ayant une corrélation avec d’autres dispositifs chirurgicaux ou avec une intervention chirurgicale
32.
CULTURE MEDIUM CONTAINING DEEP SEA WATER FOR USE IN CULTURE OF TISSUE CELL DERIVED FROM FETAL APPENDAGE AND/OR CORD BLOOD CELL
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Sagara, Yusuke
Abrégé
Provided is a culture medium suitable for the production of a nerve regeneration promoting substance by a tissue cell derived from a fetal appendage and/or a cord blood cell.
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Sagara, Yusuke
Abrégé
Provided is a cranial nerve disorder therapeutic agent that includes, as an active ingredient, a culture supernatant of tissue cells derived from a fetal appendage.
A61K 35/28 - Moelle osseuseCellules souches hématopoïétiquesCellules souches mésenchymateuses de toutes origines, p. ex. cellules souches dérivées de tissu adipeux
A61K 9/19 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres lyophilisées
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Sagara, Yusuke
Abrégé
Provided is a cranial neuropathy therapeutic agent that contains, as an active ingredient, a culture supernatant for umbilical cord blood monocytic cells.
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Naka, Tetsuji
Serada, Satoshi
Abrégé
The present disclosure provides a humanized antibody specifically binding to glypican-1 (GPC-1) and a technique, a method, a drug, etc., each related thereto. In one aspect, the present disclosure provides a humanized anti-GPC-1 monoclonal antibody that has high affinity to GPC-1 and exhibits high internalization activity in GPC-1 positive cells. In another aspect, the present disclosure provides a composition for preventing or treating glypican-1-positive cancer, said composition comprising a complex of the humanized anti-GPC-1 monoclonal antibody with a drug having cytotoxic activity.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p. ex. un fragment Fc
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Naka, Tetsuji
Serada, Satoshi
Abrégé
The present disclosure provides a composition for treating a type of cancer which has CAFs (e.g., a refractory tumor). In one aspect, the present disclosure provides a composition for treating a type of cancer which has cancer-associated fibroblasts (CAFs), the composition comprising a complex of an anti-GPC-1 antibody or an antigen-binding fragment thereof and a drug having a cytotoxic activity. In some embodiments, the type of cancer which can be treated with the composition according to the present disclosure may have stromas. In some embodiments, the composition according to the present disclosure may treat a type of cancer which has a stroma content of at least about 30%.
A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p. ex. un fragment Fc
A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
37.
ESTABLISHMENT OF MOUSE MODEL USING HUMAN PANCREATIC CANCER ORGANOID
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY (Japon)
Inventeur(s)
Taniuchi, Keisuke
Taniguchi, Hideki
Abrégé
The purpose of the present invention is to provide a mouse model for pancreatic cancer similar to human pancreatic cancer. Specifically, the present invention pertains to a human pancreatic cancer mouse model which carries a pancreatic cancer organoid containing a human pancreatic cancer cell line S2-130.
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
SPECTRO DECYPHER, INC. (Japon)
Inventeur(s)
Tsuda Masashi
Tsuda Masayuki
Nakayama Noboru
Nakaoka Shigeru
Abrégé
A specimen S to which 17O gas has been administered is placed within a fixed uniform static magnetic field of an NMR apparatus 1. The sample is irradiated, through proton coupling, with an excitation pulse produced using a pulse sequence having a short cycle time of 20.4 msec or less, preferably 10.4 msec or less, and more preferably 5.6 msec or less. An NMR signal generated due to 17O nuclei of 17O water produced within the specimen by oxygen metabolism of the 17O gas being excited by irradiation with the excitation pulse is detected with high sensitivity and is processed in accordance with a prescribed imaging sequence in which an MRS sequence is used.
G01R 33/485 - Systèmes d'imagerie RMN avec sélection de signaux ou de spectres de régions particulières du volume, p. ex. spectroscopie in vivo basés sur l'information de déplacement chimique
G01N 24/00 - Recherche ou analyse des matériaux par l'utilisation de la résonance magnétique nucléaire, de la résonance paramagnétique électronique ou d'autres effets de spin
G01N 24/08 - Recherche ou analyse des matériaux par l'utilisation de la résonance magnétique nucléaire, de la résonance paramagnétique électronique ou d'autres effets de spin en utilisant la résonance magnétique nucléaire
A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
TOKYO UNIVERSITY OF SCIENCE FOUNDATION (Japon)
Inventeur(s)
Taniuchi Keisuke
Wada Takeshi
Hara Rintaro
Sato Kazuki
Takagi Kazunori
Abrégé
Provided is a novel anti-tumor agent capable of delivering siRNA or shRNA specifically to pancreatic cancer cells and suppressing tumor enlargement, infiltration, and metastasis of pancreatic cancer. The present invention provides a nucleic acid delivery enhancer that is for delivering siRNA or shRNA into cells and that comprises a folate-cationic oligopeptide complex. The present invention also provides an anti-tumor agent that contains a folate-cationic oligopeptide complex and siRNA or shRNA capable of binding to mRNA or snoRNA expressed in pancreatic cancer cells to inhibit the expression. Said siRNA is capable of binding to RNA selected from the group consisting of, for example, SNORA18 snoRNA, NUP85 mRNA, WASF2 mRNA, and SNORA22 snoRNA.
A61K 31/7105 - Acides ribonucléiques naturels, c.-à-d. contenant uniquement des riboses liés à l'adénine, la guanine, la cytosine ou l'uracile et ayant des liaisons 3'-5' phosphodiester
A61K 31/713 - Acides nucléiques ou oligonucléotides à structure en double-hélice
A61K 47/22 - Composés hétérocycliques, p. ex. acide ascorbique, tocophérol ou pyrrolidones
A61K 47/42 - ProtéinesPolypeptidesLeurs produits de dégradationLeurs dérivés p. ex. albumine, gélatine ou zéine
A61P 1/18 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des troubles pancréatiques, p. ex. enzymes pancréatiques
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Seki, Yasutaka
Abrégé
The present invention addresses the problem of more rapidly predicting the three-dimensional structure of a peptide of interest. The problem is solved by a method for predicting the nuclear magnetic resonance chemical shift values of peptides, the method comprising a step for clustering the occurrence frequency distribution of the main chain dihedral angle values (represented by φ and ψ) of the individual amino acid residues constituting a peptide of interest, to acquire a plurality of cluster distributions; a step for calculating, using a score function, the degree of similarity between each acquired cluster distribution and reference main chain dihedral angle values registered in an amino acid tripeptide database; and a step for predicting, from the calculated degree of similarity, the nuclear magnetic resonance chemical shift values of the peptide of interest.
G01N 23/20 - Recherche ou analyse des matériaux par l'utilisation de rayonnement [ondes ou particules], p. ex. rayons X ou neutrons, non couvertes par les groupes , ou en utilisant la diffraction de la radiation par les matériaux, p. ex. pour rechercher la structure cristallineRecherche ou analyse des matériaux par l'utilisation de rayonnement [ondes ou particules], p. ex. rayons X ou neutrons, non couvertes par les groupes , ou en utilisant la diffusion de la radiation par les matériaux, p. ex. pour rechercher les matériaux non cristallinsRecherche ou analyse des matériaux par l'utilisation de rayonnement [ondes ou particules], p. ex. rayons X ou neutrons, non couvertes par les groupes , ou en utilisant la réflexion de la radiation par les matériaux
G01N 24/00 - Recherche ou analyse des matériaux par l'utilisation de la résonance magnétique nucléaire, de la résonance paramagnétique électronique ou d'autres effets de spin
41.
METHOD FOR ENHANCING LUMINOUS INTENSITY OF FLUORESCENT DYE
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Niko, Yosuke
Hadano, Shingo
Watanabe, Shigeru
Nakayama, Taku
Inoue, Keiji
Hanazaki, Kazuhiro
Kaneko, Masuomi
Abrégé
The purpose of the present invention is to provide: a method by which the luminous intensity of a fluorescent dye is able to be enhanced even with use of light having a peak wavelength other than the maximum absorption wavelength; and a method for detecting cancer tissues, wherein the above-described method is applied. A method for enhancing the luminous intensity of a fluorescent dye according to the present invention is characterized by comprising: a step for mixing a fluorescent dye (I) with an O/W emulsion that contains, in oil droplets, at least a fat-soluble compound having a functional group that causes a bio-orthogonal reaction with the fluorescent dye (I) and a fluorescent dye (II) having a maximum absorption wavelength that is different from the maximum absorption wavelength of the fluorescent dye (I) and a maximum fluorescence wavelength that is within the absorption wavelength range of the fluorescent dye (I); and a step for irradiating the mixture of the fluorescent dye (I) and the O/W emulsion with excitation light of the fluorescent dye (II).
C09K 11/06 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances organiques luminescentes
A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
G01N 21/78 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique produisant un changement de couleur
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Sato Takayuki
Abrégé
An openable and closable clip 1A for medical use which comprises a resin clip body 10 and a fastening ring 2 which fits onto the clip body 10, wherein the clip body 10 includes a pair of opposing arm parts 11 and a connecting part 12 that connects base ends of the arm parts 11, and each arm part 11 has a curved part 14 on a base end side, a holding part 15 on a distal end side, and an intermediate part 16 between the curved part 14 and the holding part 15. The curved part 14 is curved in an arc shape, and the intermediate part 16 has a thickness greater than the thickness of the curved part 14. The clip body 10 closes in a state in which the fastening ring 2 is fitted onto the clip body 10 on the connecting part 12 side of the curved part 14, opens in a state in which the fastening ring 2 is slid onto the curved part 14 from the connecting part 12, and closes in a state in which the fastening ring 2 is slid onto the intermediate part 16 from the curved part 14. The openable and closable clip 1A can be used in an endoscope clip device and opens and closes stably.
National University Corporation Kochi University (Japon)
Inventeur(s)
Nakai, Eiichi
Ueba, Tetsuya
Abrégé
The method for diagnosing cerebrospinal fluid hypovolemia includes injecting saline into a subdural space of a subject in a decubitus position, raising an upper body of the subject, and then determining whether the subject has headache or not, or headache of the subject is relieved or not.
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Sakurai, Naoto
Sakurai, Yoshinobu
Watanabe, Yasuyuki
Ikeda, Takeo
Sato, Takayuki
Abrégé
An object of the present invention is to provide a resin composition which can be detected both by X-ray radiation and by fluorescence or phosphorescence, and a molded article obtained from the resin composition. The present invention provides a resin composition containing a light-emitting substance and a radiopaque substance; in which the light-emitting substance is a near-infrared fluorescent material or a phosphorescent material. a radiopaque substance of the resin composition is any one of barium sulfate, bismuth oxide, bismuth subcarbonate, calcium carbonate, aluminum hydroxide, tungsten, zinc oxide, zirconium oxide, zirconium, titanium, platinum, bismuth subnitrate, and bismuth. A molded article can be obtained by processing any one of the resin compositions described above.
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
A61B 6/12 - Agencements pour détecter ou localiser des corps étrangers
C08K 3/013 - Charges, pigments ou agents de renforcement
A61L 31/18 - Matériaux au moins partiellement opaques aux rayons X ou au laser
A61L 29/14 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
A61L 29/18 - Matériaux au moins partiellement opaques aux rayons X ou au laser
A61L 27/50 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
A61L 31/14 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
G07D 7/005 - Vérification par des marquages de sécurité invisibles à l’œil nu, p. ex. vérification de lignes épaissies, de marquages ou d'altérations discrets
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Sato Takayuki
Abrégé
This medical tool for a fingertip comprises a resin layer that emits red fluorescence or near infrared fluorescence, and is to be worn on a fingertip. More specifically, the medical tool for a fingertip 1A to 1E has a finger cot shape, has an open window portion 2 from which the finger pad is exposed when worn on a finger, and is formed of a resin that emits red fluorescence or near infrared fluorescence. Alternatively, the medical tool for a fingertip 1F, 1G has a glove shape and has a print layer 8, 9 on the finger pad thereof or around the finger pad thereof, the print layer being formed of a resin that emits red fluorescence or near infrared fluorescence. Alternatively, the medical tool for a fingertip 1H, 1I is like a sticker that has an adhesive layer on one surface of a resin layer that emits red fluorescence or near infrared fluorescence, and is sized so as to be affixed within the finger pad. When an operator who performs palpation in a living body wears this medical tool for a fingertip on a fingertip, the location of a lesion identified from a mucosal side by palpation can be accurately identified from a serosal side.
A61B 42/20 - Doigtiers spécialement adaptés à la chirurgie
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
46.
WASTEWATER TREATMENT APPARATUS AND WASTEWATER TREATMENT METHOD
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
MAEZAWA INDUSTRIES, INC. (Japon)
Inventeur(s)
Fujiwara, Taku
Ishida, Susumu
Miyoshi, Taro
Nguyen, Thanh Phong
Abrégé
The present invention provides a wastewater treatment apparatus that can treat wastewater in a stable manner, and a wastewater treatment method. A wastewater treatment facility 10 is provided with an FO membrane unit 21. The FO membrane unit 21 is immersed in a sea. The FO membrane unit 21 is provided with an FO membrane 31 and a base member 32 for attaching the FO membrane 31 and has an internal space 35 formed by the FO membrane 31 and the base member 32. The wastewater to be treated is fed into the internal space 35.
B01D 61/00 - Procédés de séparation utilisant des membranes semi-perméables, p. ex. dialyse, osmose ou ultrafiltrationAppareils, accessoires ou opérations auxiliaires, spécialement adaptés à cet effet
B01D 63/00 - Appareils en général pour les procédés de séparation utilisant des membranes semi-perméables
B01D 65/02 - Nettoyage ou stérilisation de membranes
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
MAEZAWA INDUSTRIES, INC. (Japon)
Inventeur(s)
Fujiwara, Taku
Ishida, Susumu
Miyoshi, Taro
Nguyen, Thanh Phong
Ganbat, Zolzaya
Abrégé
[ABSTRACT] Provided are a wastewater treatment apparatus and a wastewater treatment method, whereby it becomes possible to achieve the satisfactory concentration of wastewater. A wastewater treatment apparatus 10 is equipped with a treatment tank 12 in which wastewater of interest is concentrated, a treatment tank 13 in which the wastewater concentrated in the treatment tank 12 is further concentrated, an FO membrane unit 14 which is arranged in the treatment tank 12 and is so configured as to have an internal space S formed by an FO membrane supporting material and an FO membrane 14a, an FO membrane unit 15 which is arranged in the treatment tank 13 and is so configured as to have an internal space T formed by an FO membrane supporting material and an FO membrane 15a, a driving solution circulating facility 18 for circulating a driving solution DS to be fed to the internal space S in the FO membrane unit 14 between the driving solution circulating facility 18 and the FO membrane unit 14, and a driving solution circulating facility 17 for circulating a driving solution DS to be fed to the internal space T in the FO membrane unit 15 between the driving solution circulating facility 17 and the FO membrane unit 15, wherein the driving solution DS to be used in the treatment tank 12 is composed of the driving solution DS used in the treatment tank 13 for the purpose of further concentrating the wastewater concentrated in the treatment tank 12 and water contained in the wastewater of interest moved into the driving solution DS through the FO membrane 15a.
B01D 61/00 - Procédés de séparation utilisant des membranes semi-perméables, p. ex. dialyse, osmose ou ultrafiltrationAppareils, accessoires ou opérations auxiliaires, spécialement adaptés à cet effet
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Ishikawa, Katsumi
Amenomori, Daiji
Hamauzu, Yasuomi
Abrégé
a carrying to outside hydrogen-containing electrolyzed water generated by electrolysis in the first electrode chamber Da; and a charge amount adjuster 10 for adjusting, during the electrolysis, an amount of electrical charge to be provided to the hydrogen-containing electrolyzed water. The charge amount adjuster 10 adjusts the amount of electrical charge per unit quantity of the generated hydrogen-containing electrolyzed water through control of an electrolytic current or an electrolytic voltage.
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Tanaka, Tohru
Takahashi, Kiwamu
Inoue, Keiji
Saito, Motoaki
Tsuda, Masayuki
Fukuhara, Hideo
Kuno, Takahira
Shimizu, Shogo
Abrégé
Various side effects are reported for existing overactive bladder therapeutic drugs, and prophylactic or therapeutic agents for overactive bladder without side effects have been eagerly desired. The present invention provides a prophylactic or therapeutic agent for overactive bladder that comprises 5-aminolevulinic acids (ALAs) as the active ingredient.
A61K 31/197 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe amino les groupes amino et carboxyle étant liés à la même chaîne carbone acyclique, p. ex. acide gamma-aminobutyrique [GABA], bêta-alanine, acide epsilon-aminocaproïque ou acide pantothénique
A61P 13/10 - Médicaments pour le traitement des troubles du système urinaire de la vessie
JAPAN AGENCY FOR MARINE-EARTH SCIENCE AND TECHNOLOGY (Japon)
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
National Institute of Advanced Industrial Science and Technology (Japon)
Inventeur(s)
Taira, Yousuke
Kuwamori, Naoki
Hoshino, Tatsuhiko
Onodera, Jonaotaro
Yamaguchi, Tatsuhiko
Tomioka, Kyoko
Itaki, Takuya
Abrégé
An analysis apparatus (100) includes an image acquisition unit (110) and an analysis unit (120). The image acquisition unit (110) acquires image data of a microfossil in a sample collected from a stratum. The analysis unit (120) analyzes the image data acquired by the image acquisition unit (110) using a machine learning result to analyze a taxon or kind of the microfossil in the image data.
G06K 9/00 - Méthodes ou dispositions pour la lecture ou la reconnaissance de caractères imprimés ou écrits ou pour la reconnaissance de formes, p.ex. d'empreintes digitales
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Ueba, Tetsuya
Minakuchi, Kiyomi
Fukuda, Hitoshi
Abrégé
This diagnosis support device (3), which supports a diagnosis of a vascular disease, includes: an image acquisition unit (341) which acquires an image including a cross section of a blood vessel; a line segment setting unit (342) which sets one or more line segments crossing the cross section; and a luminance distribution calculation unit (343) which calculates a luminance distribution on the line segment.
A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Hiraoka, Masanori
Tanaka, Kouki
Abrégé
The problem addressed by the present invention is to provide a technique for producing seaweed easily and efficiently. The problem is solved by a method for producing seaweed cells that includes a step for culturing under stirred conditions at least one selected from the group consisting of seaweed spores, single cells derived from the spores, and a cell mass of the spores and/or the single cells in a medium 1 substantially free of seaweed morphogens.
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY (Japon)
NATIONAL INSTITUTES FOR QUANTUM AND RADIOLOGICAL SCIENCE AND TECHNOLOGY (Japon)
Inventeur(s)
Mori, Masanobu
Ohira, Shin-Ichi
Toda, Kei
Sugo, Yumi
Watanabe, Shigeki
Ishioka, Noriko
Abrégé
The objective of the present invention is to separate a metal RI in a short time. A separating device 3 for separating a radioisotope (RI) from a first solution containing a metal and the RI, obtained by transformation of the metal, is provided with an electrode 31 for applying a prescribed voltage to the first solution, wherein the prescribed voltage is a voltage with which a rate of electrodeposition of the metal onto the electrode 31 is different from the rate of electrodeposition of the RI onto the electrode 31.
G21G 4/08 - Sources radioactives autres que les sources de neutrons caractérisées par des aspects de leur structure spécialement adaptées aux applications médicales
B01D 59/38 - Séparation par méthodes électrochimiques
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Oshima, Shun-Ichirou
Ohguro, Kazuki
Shimamoto, Shu
Nakamura, Toshikazu
Abrégé
The present invention addresses the problem of providing a fish rearing feed having an excellent effect to prevent infectious diseases. A fish rearing feed which contains a water-soluble polysaccharide that does not have a substituent other than a hydroxy group in an amount of 4% by weight or less. A fish rearing feed which contains cellulose acetate having an acetyl total substitution degree of 0.4 to 1.4 inclusive.
A23K 50/80 - Produits alimentaires spécialement conçus pour des animaux spécifiques pour les animaux aquatiques, p. ex. pour les poissons, les crustacés ou les mollusques
A01K 61/13 - Prévention ou traitement des maladies des poissons
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Komatsu Shizuo
Takeuchi Hiroaki
Abrégé
(Problem) To provide an intestinal flora-improving health food that improves intestinal flora by increasing and activating equol-producing bacteria via containing a bittern. (Solution) This intestinal flora-improving health food is characterized in that: per 100 g of the health food, the content of magnesium is 2500-6000 mg, and the content of calcium is 500-2000 mg; the ratio of magnesium content to calcium content is 2-7; the health food has a hardness of 144000-383000 mg/L; and a bittern is contained in an amount of 0.8-1.5 wt% with respect to the total weight of the health food.
A23L 33/16 - Sels inorganiques, minéraux ou oligo-éléments
A23L 11/00 - Légumes secs, c.-à-d. fruits de plantes légumineuses, pour l'obtention d'alimentsProduits dérivés de légumineusesLeur préparation ou leur traitement
A23L 11/20 - Produits à base de malt; Produits à base de malt fermenté
A61K 9/48 - Préparations en capsules, p. ex. de gélatine, de chocolat
A61K 33/06 - Aluminium, calcium ou magnésiumLeurs composés
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Fukuda, Ken
Matsuzaki, Shigenobu
Fukushima, Atsuki
Daibata, Masanori
Uchiyama, Jumpei
Abrégé
The purpose of the present invention is to provide a novel bacteriophage effective for the treatment of bacterial endophthalmitis and a treatment agent for bacterial endophthalmitis that contains this novel bacteriophage. The bacterial endophthalmitis treatment agent according to the present invention is characterized by containing at least one bacteriophage selected from the group indispensably consisting of Myoviridae Spounavirinae phiEF7H (Accession No.: NITE BP-02886), Myoviridae Spounavirinae phiEF19G (Accession No.: NITE BP-02887), Myoviridae Spounavirinae phiEF14H1 (Accession No.: NITE BP-02888), and mutants thereof.
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
JSR CORPORATION (Japon)
Inventeur(s)
Onodera, Kenichi
Higashi, Yoichiro
Saito, Motoaki
Abrégé
The purpose of the present invention is to provide a medicine for effectively protecting brain tissues from inflammatory reactions induced by cerebral ischemia. The brain protective agent according to the present invention is characterized by comprising a specific carotenoid compound as an active ingredient.
A61K 31/336 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à trois chaînons, p. ex. oxirane, fumagilline
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
58.
FLUORESCENT COMPOUND RESPONDING TO MITOCHONDRIAL MEMBRANE POTENTIAL
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Kawamata, Jun
Suzuki, Yasutaka
Asamura, Naoya
Niko, Yosuke
Seki, Hitomi
Abrégé
The present invention addresses the problem of providing a compound that is a pigment capable of staining cells, is water-soluble, shows a high light emission efficiency, translocates from mitochondria to nucleus depending on mitochondrial membrane potential and exhibits light emission in the red color region. The compound according to the present invention is expressed by formula (1) [in formula (1): X is represented by formula (2) (in formula (2), R1represents a C1-C10 alkyl group, and Z-represents a counter anion to a pyridinium cation); k and m are an integer of 0-3 and l and n are an integer of 0-2, provided that k, l, m and n do not simultaneously represent 0; X's may be the same or different; R2represents an electron-donating group or an electron-withdrawing group; a and c are an integer of 0-3 and b and d are an integer of 0-2; R2's may be either the same or different and attached to a carbon atom which is not substituted by X; and the wavy line represents a geometric isomer E or Z].
C09K 11/06 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances organiques luminescentes
C12Q 1/02 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des micro-organismes viables
G01N 21/78 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique produisant un changement de couleur
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
DAICEL CORPORATION (Japon)
Inventeur(s)
Miyata, Tsuyoshi
Oshima, Syun-Ichirou
Kato, Motomi
Miki, Katsuya
Iwatani, Masao
Fujisawa, Suguru
Abrégé
An object of the present invention is to provide a system for monitoring a cardiac condition of a fish wherein the system comprises: a container and a processor, wherein the container is provided with a plurality of detectors on an inner wall surface of said container, and has a space where the fish can swim on an opposite side from said detectors side as viewed from the fish in said container, the processor includes: an acquisition section that acquires photoelectric pulse waves in a plurality of areas of the fish under signal synchronization in time sequence for a specified detection period via measurement equipment having the detectors; and an extraction section that extracts a portion reflecting the photoelectric pulse wave in a heart area of the fish the most from the photoelectric pulse waves in the areas that are acquired in the detection period.
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
DAICEL CORPORATION (Japon)
Inventeur(s)
Miyata, Tsuyoshi
Oshima, Syun-Ichirou
Kato Motomi
Miki, Katsuya
Iwatani, Masao
Fujisawa, Suguru
Abrégé
The present invention addresses the problem of providing a system for monitoring the heart condition a target fish in a state equivalent to a natural state. This problem is solved by a system for monitoring the heart condition of fish that is provided with a container and a processing device, wherein the container includes a plurality of detectors on the inner wall surface of the container and a space in which fish can swim on the side opposite to the detector side, with respect to the fish in the container, and the processing device includes an acquisition unit that acquires, in a time series, photoelectric pulse waves of a plurality of parts of the fish over a predetermined detection period under signal synchronization through a measurement device having the plurality of detectors, and an extracting unit that extracts a portion that most reflects the photoelectric pulse wave of the heart part of the fish from the photoelectric pulse waves of the plurality of parts acquired during the detection period.
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Taniuchi, Keisuke
Abrégé
The present invention addresses the problem of providing a cancer marker that has high sensitivity and specificity and can predict the "prognosis" of a pancreatic cancer patient. A marker for prognosis of pancreatic cancer according to the present invention is characterized by containing a combination of protein ITGB1 and protein PODXL and/or protein BCL7B. The present disclosure includes: a kit for diagnosing the prognosis of pancreatic cancer, characterized by comprising an antibody directed against protein ITGB1 and an antibody directed against protein PODXL and/or an antibody directed against protein BCL7B; and a method for predicting the prognosis of pancreatic cancer, characterized by comprising a step of measuring the immunohistochemistry score of each of protein ITGB1 and at least one protein selected from the group consisting of protein PODXL and protein BCL7B in a sample or the concentration of each of protein ITGB1 and at least one protein selected from the group consisting of protein PODXL and protein BCL7B in the sample.
G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
C07K 14/705 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
C07K 16/30 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire provenant de cellules de tumeurs
62.
Marker for pancreatic cancer and intraductal papillary mucinous neoplasms
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Taniuchi, Keisuke
Abrégé
A marker having excellent sensitivity and specificity to pancreatic cancer and intraductal papillary mucinous neoplasms. Also, a kit for diagnosing pancreatic cancer and intraductal papillary mucinous neoplasms to detect the marker, and a method for evaluating a metastasis of a pancreas cancer cell by using the marker. The marker for pancreatic cancer and intraductal papillary mucinous neoplasms according to the present invention comprises one or more proteins selected from the group essentially consisting of secretoglobin, family 1D, member 2 and podocalyxin-like protein. The kit for diagnosing pancreatic cancer and intraductal papillary mucinous neoplasms according comprises an antibody to one or more proteins selected from the group essentially consisting of secretoglobin, family 1D, member 2 and podocalyxin-like protein.
G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
C07K 16/30 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire provenant de cellules de tumeurs
63.
PROPHYLACTIC OR THERAPEUTIC AGENT FOR HYPERACTIVE BLADDER
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Tanaka, Tohru
Takahashi, Kiwamu
Inoue, Keiji
Saito, Motoaki
Tsuda, Masayuki
Fukuhara, Hideo
Kuno, Takahira
Shimizu Shogo
Abrégé
[Problem] Various side effects have been reported for conventional therapeutic drugs for hyperactive bladder, and a prophylactic or therapeutic agent for hyperactive bladder without causing side effects is desired. [Solution] Provided is a prophylactic or therapeutic agent for hyperactive bladder, said agent containing 5-aminolevulinic acids (ALA) as an active ingredient.
A61K 31/197 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe amino les groupes amino et carboxyle étant liés à la même chaîne carbone acyclique, p. ex. acide gamma-aminobutyrique [GABA], bêta-alanine, acide epsilon-aminocaproïque ou acide pantothénique
JAPAN AGENCY FOR MARINE-EARTH SCIENCE AND TECHNOLOGY (Japon)
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (Japon)
Inventeur(s)
Taira Yousuke
Kuwamori Naoki
Hoshino Tatsuhiko
Onodera Jonaotaro
Yamaguchi Tatsuhiko
Tomioka Kyoko
Itaki Takuya
Abrégé
An analysis device (100) is provided with an image acquisition unit (110) and an analysis unit (120). The image acquisition unit (110) acquires image data of a microfossil in a sample obtained from a stratum. The analysis unit (120) analyzes, using machine learning results, image data acquired by the image acquisition unit (110), and thereby analyzes the taxon or category of the microfossil in the image data.
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique
G01N 21/17 - Systèmes dans lesquels la lumière incidente est modifiée suivant les propriétés du matériau examiné
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Naka Tetsuji
Serada Satoshi
Fujimoto Minoru
Abrégé
Provided is a novel anti-Glypican-1 antibody and a method for using the same. Provided is an anti-Glypican-1 antibody having an intracellular migration activity which has never been observed in conventional anti-Glypican-1 antibodies. By taking advantage of the intracellular migration activity of the antibody according to the present invention, the present invention is usable for various therapeutic purposes beyond the scope of the conventional assumption. Also provided is a composition for preventing or treating Glypican-1 positive cancer, said composition comprising a complex of a substance capable of binding to Glypican-1 (for example, an anti-Glypican-1 antibody) with a drug having a cytotoxic activity.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A01H 1/00 - Procédés de modification des génotypes
A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
NIPPON PAPER INDUSTRIES CO., LTD. (Japon)
Inventeur(s)
Oshima Shunichiro
Kubota Satoshi
Yamane Jin
Sato Nanako
Nishikawa Maiko
Nakamura Yasuyuki
Omura Tomonobu
Yamaguchi Shinya
Matsuda Manabu
Hashimoto Tadafumi
Abrégé
The present invention addresses the problem of providing a feed which contributes to the improvement of the growth of aquatic animals. The present invention also addresses the problem of providing a feed by which the onset of disease injury can be suppressed during rearing or culturing aquatic animals. A feed comprising a nucleic acid such as RNA is prepared and fed for various purposes, for example, increasing feed intake, increasing feed conversion efficiency and improving biophylactic function.
A23K 50/80 - Produits alimentaires spécialement conçus pour des animaux spécifiques pour les animaux aquatiques, p. ex. pour les poissons, les crustacés ou les mollusques
A23K 20/153 - Acides nucléiquesLeurs hydrolysats ou dérivés
A61K 31/7052 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p. ex. nucléosides, nucléotides
A61K 31/7105 - Acides ribonucléiques naturels, c.-à-d. contenant uniquement des riboses liés à l'adénine, la guanine, la cytosine ou l'uracile et ayant des liaisons 3'-5' phosphodiester
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Ishikawa, Katsumi
Amenomori, Daiji
Koizumi, Yoshinobu
Hamauzu, Yasuomi
Abrégé
a connected to the first electrode chamber Da, and dispensing out of the first electrode chamber Da electrolyzed hydrogen water generated by electrolysis in the first electrode chamber Da; and a charge amount adjuster 10 connected to the electrolysis tank D to adjust an amount of electrical charge to be provided to the electrolyzed hydrogen water. The charge amount adjuster 10 adjusts, based on a flow rate of the raw water, the amount of the electrical charge per unit quantity of the generated electrolyzed hydrogen water through control of an electrolytic current or an electrolytic voltage, so that the adjusted amount of the electrical charge is constant.
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
KYOTO UNIVERSITY (Japon)
THE UNIVERSITY OF TOKYO (Japon)
RIKEN (Japon)
WASEDA UNIVERSITY (Japon)
Inventeur(s)
Yamada, Kazuhiko
Takeda, Kazuyuki
Usami, Koji
Nakamura, Yasunobu
Yamazaki, Rekishu
Noguchi, Atsushi
Nagasaka, Kentaro
Takahashi, Masato
Iwase, Eiji
Abrégé
The purpose of the present invention is to provide a magnetic resonance device having new element technology which detects a magnetic resonance signal with a high sensitivity. The magnetic resonance device is provided with: a magnetic field generating unit 1 which generates a magnetic field to be applied to a sample S; an excitation high frequency generating unit 2 which generates an excitation high frequency; a transmission coil 31 which irradiates the sample S disposed in the magnetic field, with the excitation high frequency; a reception coil 41 which receives a magnetic resonance signal generated by the sample S excited by the excitation high frequency; an electrical-to-mechanical transducer 42 which transforms a voltage of the magnetic resonance signal to a vibration of a capacity coupling film M; and a vibration measuring unit 5 which measures the vibration of the film M on the basis of optical interference.
G01R 33/34 - Détails de structure, p. ex. résonateurs
G01N 24/10 - Recherche ou analyse des matériaux par l'utilisation de la résonance magnétique nucléaire, de la résonance paramagnétique électronique ou d'autres effets de spin en utilisant la résonance paramagnétique électronique
G01R 33/36 - Détails électriques, p. ex. adaptations ou couplage de la bobine au récepteur
69.
Method for specifying leakage part of cerebrospinal fluid in cerebrospinal fluid hypovolemia patient, and method for treating cerebrospinal fluid hypovolemia
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Nakai, Eiichi
Abrégé
The objective of the present invention to provide a method for accurately and safely specifying a leakage part of cerebrospinal fluid in a cerebrospinal fluid hypovolemia patient, and a method for effectively treating cerebrospinal fluid hypovolemia with utilizing the specifying method. The method for specifying a leakage part of cerebrospinal fluid in a cerebrospinal fluid hypovolemia patient according to the present invention is characterized in comprising the steps of injecting saline into a bone-marrow space of a spine of the cerebrospinal fluid hypovolemia patient, and detecting the cerebrospinal fluid or the injected saline leaked from a dura mater of the spine to specify the leakage part of the cerebrospinal fluid.
A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Taniuchi, Keisuke
Abrégé
The purpose of the present invention is to provide a marker that indicates pancreatic cancer and intraductal papillary mucinous tumors, with high sensitivity and specificity. Furthermore, the purpose of the present invention is also to provide a diagnostic kit for pancreatic cancer and intraductal papillary mucinous tumors, which detects this marker, and a method for evaluating metastatic pancreatic cancer and intraductal papillary mucinous tumors, using the marker. This marker of pancreatic cancer and intraductal papillary mucinous tumors is characterized by including one or more proteins, selected from the group consisting of secretoglobin family-1D member 2, and podocalyxin-like protein. Furthermore, this diagnostic kit for pancreatic cancer and intraductal papillary mucinous tumors is characterized by including an antibody for one or more proteins selected from the group consisting of secretoglobin family-1D member 2, and podocalyxin-like protein.
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
National University Corporation, Kochi University (Japon)
Inventeur(s)
Naka, Tetsuji
Serada, Satoshi
Fujimoto, Minoru
Toyoura, Masayoshi
Shoya, Yuji
Abrégé
The present invention relates to an esophageal cancer marker and application thereof. The present invention relates to: a marker that includes Glypican-1 or an expression product thereof, or a fragment or derivative thereof, and serves to identify esophageal cancer; a detection agent that includes a substance that binds to Glypican-1 or an expression product thereof; and a composition that includes a Glypican-1 inhibitor and serves to prevent or treat esophageal cancer. Herein, Glypican-1 can be SEQ ID NO: 1 (nucleic acid sequence) or SEQ ID NO: 2 (amino acid sequence), or an equivalent thereof.
C07K 16/30 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire provenant de cellules de tumeurs
A61K 31/713 - Acides nucléiques ou oligonucléotides à structure en double-hélice
G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
National University Corporation Kochi University (Japon)
Inventeur(s)
Naka, Tetsuji
Serada, Satoshi
Fujimoto, Minoru
Toyoura, Masayoshi
Shoya, Yuji
Abrégé
According to the present disclosure there are provided compositions and methods for treating malignant tumors, including an anti-LSR (lipolysis stimulated lipoprotein receptor) antibody that comprises the presently disclosed antibody heavy and light chain complementarity determining region (CDR) sequences, or an antigen-binding fragment thereof, or a functional equivalent thereof. Further provided for treating an LSR-positive malignancy is an LSR antagonist or an LSR inhibitor such as a nucleic acid. Therapeutic administration of the anti-LSR antibody to a subject having an LSR-positive malignant tumor is also described.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A61K 31/713 - Acides nucléiques ou oligonucléotides à structure en double-hélice
G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
C07K 16/30 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire provenant de cellules de tumeurs
G01N 33/92 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des lipides, p. ex. le cholestérol
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Yaguchi, Tomonori
Morii, Kenji
Kawakami, Yutaka
Kato, Daiki
Naka, Tetsuji
Serada, Satoshi
Fujimoto, Minoru
Abrégé
The purpose of the present invention is to produce a chimeric antigen receptor (CAR) specific to glypican-1 (GPC-1) and to treat squamous cell carcinoma with genetically modified cells capable of expressing the CAR. The present invention provides: a chimeric antigen receptor for use in the treatment and/or prevention of squamous cell carcinoma, said chimeric antigen receptor comprising an extracellular domain capable of binding to GPC-1, a transmembrane domain and one or multiple intracellular domains, wherein at least one of the intracellular domains is an intracellular domain containing a primary cytosolic signaling sequence or an intracellular domain containing both a primary cytosolic signaling sequence and a secondary cytosolic signaling sequence; a genetically modified cell capable of expressing the chimeric antigen receptor; and a cell preparation containing the cell.
A61K 31/7088 - Composés ayant au moins trois nucléosides ou nucléotides
A61K 35/12 - Substances provenant de mammifèresCompositions comprenant des tissus ou des cellules non spécifiésCompositions comprenant des cellules souches non embryonnairesCellules génétiquement modifiées
A61K 38/00 - Préparations médicinales contenant des peptides
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Ishikawa, Katsumi
Amenomori, Daiji
Koizumi, Yoshinobu
Hamauzu, Yasuomi
Abrégé
An electrolyzed water-generating apparatus 1 is provided with: a first electrode chamber Da with a negative electrode 6a; a first water entry passage 4a connected to the first electrode chamber Da for supplying raw water to the first electrode chamber Da from the outside; a first water extraction passage 7a connected to the first electrode chamber Da for extracting electrolyzed hydrogen water generated in the first electrode chamber Da by electrolysis to the outside; and an electric charge-adjusting device (10) connected to the electrolysis tank D for adjusting the electric charge to be imparted to the electrolyzed hydrogen water when performing electrolysis. The electric charge-adjusting device 10 is characterized in adjusting electric charge by controlling the electrolysis current or electrolysis voltage on the basis of the flow of raw water so that the charge per unit volume of electrolyzed hydrogen water extracted is constant.
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Sakurai Naoto
Ikeda Takeo
Sakurai Yoshinobu
Watanabe Yasuyuki
Sato Takayuki
Abrégé
Provided is a resin composition that has a maximum fluorescent wavelength of at least 650 nm and contains a resin and a near-infrared fluorescent pigment comprising at least one compound selected from the group consisting of compounds represented by general formulas (I1), (I2). (In the formulas, Rh and Ri, as well as Rj and Rk, form an aromatic 5-membered ring, an aromatic 6-membered ring, or a condensed aromatic ring together with the nitrogen atoms to which Rh, Ri, Rj, and Rk are bonded; each of Rl, Rm, Rn, and Ro independently represents a halogen atom, a C1-20 alkyl group, a C1-20 alkoxy group, an aryl group, or a heteroaryl group; Rr and Rs represent a hydrogen atom or an electron-withdrawing group; and each of Rp and Rq independently represents a hydrogen atom, a halogen atom, a C1-20 alkyl group, a C1-20 alkoxy group, an aryl group, or a heteroaryl group.)
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Sakurai Naoto
Sakurai Yoshinobu
Watanabe Yasuyuki
Ikeda Takeo
Sato Takayuki
Abrégé
Provided is a resin composition characterized by containing a resin, a light-emitting substance, and a radiopaque substance, wherein the content of the radiopaque substance is 2 mass% to 80 mass%. Also provided is any of the abovementioned resin compositions wherein the content of the light-emitting substance is 0.001 mass% to 0.5 mass%. Also provided is any of the abovementioned resin compositions wherein the light-emitting substance is a near-infrared fluorescent material or a phosphorescent material. Also provided is any of the abovementioned resin compositions wherein the radiopaque substance is barium sulfate, bismuth oxide, bismuth subcarbonate, calcium carbonate, aluminum hydroxide, tungsten, zinc oxide, zirconium oxide, zirconium, titanium, platinum, bismuth subnitrate, or bismuth. Also provided is a molded body obtained by processing any of the abovementioned resin compositions.
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Ishikawa, Katsumi
Amenomori, Daiji
Hamauzu, Yasuomi
Abrégé
An electrolyzed water-generating apparatus (1) is provided with: an electrolysis tank (D) equipped therein with a first electrode chamber (Da) with a cathode (6a), a second electrode chamber (Db) with an anode (6b), and a septum (Sp) for partitioning the first electrode chamber (Da) from the second electrode chamber (Db); a first inlet water path (4a), which is connected to the first electrode chamber (Da) and is for supplying raw water to the first electrode chamber (Da) from the outside; a first extraction water path (7a), which is connected to the first electrode chamber (Da) and is for extracting electrolyzed hydrogen water generated in the first electrode chamber (Da) by electrolysis to the outside; and an electric charge-adjusting device (10), which is connected to the electrolysis tank (D) and is for adjusting the electric charge applied on the electrolyzed hydrogen water when performing the electrolysis. The electric charge-adjusting device (10) is characterized in adjusting the electric charge per unit volume of electrolyzed hydrogen water taken from the device by controlling the electrolytic current or electrolytic voltage.
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
NIPPON COVIDIEN LTD. (Japon)
Inventeur(s)
Sato, Takayuki
Miyasaka, Susumu
Abrégé
A living body pressing clip (1A) comprises a clip body (10) and a cylindrical member (20) that is slidably attached to the clip body (10) and fastens the clip body (10). The clip body (10) is provided with arm parts (11) that hold a mucosal tissue in a luminal organ when fastened by the cylindrical member (20). The cylindrical member (20) is provided with a pressing part (22) that presses the mucosa in a direction of thinning the thickness (D) of the mucosa in the state where the cylindrical member (20) fastens the clip body (10) so that the clip body (10) holds the mucosal tissue in the luminal organ. The pressing part (22) contains a fluorescent dye capable of emitting a red or near-infrared light when irradiated with an exciting light. By using this living body pressing clip (1A), a light-emitting site of a light-emitting marker attached to a mucosal tissue in a luminal organ can be confirmed with a good visibility, even in the case of observing from outside the luminal organ.
A61B 19/00 - Instruments, outillage ou accessoires pour la chirurgie ou le diagnostic non couverts par l'un des groupes A61B 1/00-A61B 18/00, p.ex. pour stéréotaxie, opération aseptique, traitement de la luxation, protecteurs des bords des blessures(masques de protection du visage A41D 13/11; blouses de chirurgien ou vêtements pour malades A41D 13/12; dispositifs pour retirer, traiter ou transporter les liquides du corps A61M 1/00)
A61B 17/12 - Instruments, dispositifs ou procédés chirurgicaux pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p. ex. les vaisseaux sanguins ou le cordon ombilical
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Udaka, Keiko
Ishibashi, Masahide
Abrégé
The present invention provides an adjuvant for cancer antigen peptide vaccines and virus antigen peptides, containing a pertussis vaccine as a primary ingredient. The present invention also provides a therapeutic agent for a cancer or viral infectious disease, and a prophylactic agent for metastasis or recurrence of cancer or onset of virus-induced tumor, containing a cancer antigen peptide or virus antigen peptide and a pertussis vaccine. A pertussis vaccine that can be suitably used is a whole cell body pertussis vaccine. The agents of the present invention can be safely administered in a plurality of doses.
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
80.
Artery visualization device and artery imaging device
National University Corporation Kochi University (Japon)
Inventeur(s)
Sato, Takayuki
Ike, Tatsumi
Abrégé
[Problem] To provide an artery visualization device capable of very appropriately visualizing a to-be-punctured artery and an artery imaging device used for the artery visualization device.
[Solution] An artery visualization device (10) includes en irradiation unit (30) which irradiates the near-infrared light emitted from a light source (32) toward a back-side skin surface (22) at a visualization site (20) where a to-be-punctured artery (21) is running, a light guiding part (40) which encapsulates the light source and is pressed against the back-side skin surface and which is formed with a material of transmitting the near-infrared light emitted from the light source and suppressing reflection of the near-infrared light on the surface of the back-side skin surface, an optical filter (50) which blocks visible light and transmits the near-infrared light passing through a front-side skin surface (23) at the visualization site, a camera (60) (an imaging unit) which receives the near-infrared light passing through the optical filter to capture an image of the visualization site (20), and a monitor (70) (a display unit) which displays the image captured by the camera.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 90/13 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures pour la chirurgie stéréotaxique, p. ex. système stéréotaxique à cadre avec des guides pour aiguilles ou instruments, p. ex. des glissières courbes ou des articulations à rotule guidés par la lumière, p. ex. pointeurs lasers
A61B 90/11 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures pour la chirurgie stéréotaxique, p. ex. système stéréotaxique à cadre avec des guides pour aiguilles ou instruments, p. ex. des glissières courbes ou des articulations à rotule
A61M 5/42 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras avec des moyens pour insensibiliser la peau, pour soulever la peau en vue de faciliter la piqûre ou pour localiser le point du corps où la piqûre doit être effectuée
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Sakurai, Naoto
Ikeda, Takeo
Sakurai, Yoshinobu
Watanabe, Yasuyuki
Sato, Takayuki
Abrégé
ABSTRACT Disclosed is resin compositions which, in selected embodiments, emit near infrared fluorescence with high quantum yield and which can be easily prepared, and a molded article thereof. The resin compositions, in selected embodiments, contain a near infrared fluorescent material; and a resin, in which the near infrared fluorescent material is one type or two or more types of compounds selected from the group consisting of compounds represented by General Formulas (13) to (14) R Rn RqB Rr Rk Rh413/N / Rs RI/ \Rm R (13) R Dfl Rq \m/ ,D, N Rk N N / R" RV \RmR (1a) and has a maximum fluorescence wavelength of 650 nm or longer. Date Recue/Date Received 2021-11-10
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Sakurai Naoto
Ikeda Takeo
Sakurai Yoshinobu
Watanabe Yasuyuki
Sato Takayuki
Abrégé
The present invention addresses the problem of providing an easily manufactured resin composition which exhibits near-infrared fluorescence and has high luminescence quantum yield, and a molded article thereof. The present invention is a resin composition containing a resin and a near-infrared fluorescent pigment comprising at least one type of compound selected from the group consisting of compounds represented by general formulas (I1)-(I4), the maximum fluorescence wavelength of the resin composition being at least 650 nm. (In the formulas, Ra and Rb, Rc and Rd, Rh and Ri, and Rj and Rk form rings together with a nitrogen atom to which each thereof is bonded; Re and Rf represent halogen atoms or oxygen atoms; Rl, Rm, Rn, and Ro each independently represents a halogen atom, a C1-20 alkyl group, a C1-20 alkoxy group, an aryl group, or a heteroaryl group; Rg, Rr, and Rs represent hydrogen atoms or electron-accepting groups; and Rp and Rq each independently represents a hydrogen atom, a halogen atom, a C1-20 alkyl group, a C1-20 alkoxy group, an aryl group, or a heteroaryl group.)
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Sakurai, Naoto
Sakurai, Yoshinobu
Watanabe, Yasuyuki
Ikeda, Takeo
Sato, Takayuki
Abrégé
The issue addressed by the present invention is to easily provide: a resin composition with which detection by X-ray radiation, and detection by fluorescence or phosphorescence are possible; and a molded article obtained from said resin composition. The present invention is: a resin composition characterized by containing a light-emitting substance and a radiation-opaque substance; the resin composition, wherein the light-emitting substance is a near infrared fluorescent material or a phosphorescent material; a resin composition wherein the radiation-opaque substance is one of barium sulfate; bismuth oxide; bismuth subcarbonate, calcium carbonate, aluminum hydrate, tungsten, zinc oxide, zirconium oxide, zirconium, titanium, platinum, bismuth subnitrate, or bismuth; and a molded article obtained by processing one of the aforementioned resin compositions.
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Sakurai Naoto
Sakurai Yoshinobu
Watanabe Yasuyuki
Ikeda Takeo
Sato Takayuki
Abrégé
The issue addressed by the present invention is to easily provide: a resin composition with which detection by X-ray radiation, and detection by fluorescence or phosphorescence are possible; and a molded article obtained from said resin composition. The present invention is: a resin composition characterized by containing a light-emitting substance and a radiation-opaque substance; the resin composition, wherein the light-emitting substance is a near infrared fluorescent material or a phosphorescent material; a resin composition wherein the radiation-opaque substance is one of barium sulfate; bismuth oxide; bismuth subcarbonate, calcium carbonate, aluminum hydrate, tungsten, zinc oxide, zirconium oxide, zirconium, titanium, platinum, bismuth subnitrate, or bismuth; and a molded article obtained by processing one of the aforementioned resin compositions.
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
KANKYO CO., LTD. (Japon)
Inventeur(s)
Kakinuma, Yoshihiko
Ike, Hidetoshi
Abrégé
Disclosed is a device which can promote the in vivo production of acetylcholine. An in vivo acetylcholine production-promoting device is equipped with: an artery-compressing member which contacts with any site of four limbs and compresses an artery located at the site when the artery-compressing member is pressurized; and a pressurizing means which is connected to the artery-compressing member, pressurizes the artery-compressing member to compress the artery so that the flow of blood in the artery is interrupted during use and releases the pressurized state to re-perfuse blood through the artery. By applying the device to an animal body and repeating the interruption of blood flow and the reperfusion of blood in an artery in four limbs, the production of acetylcholine can be promoted and the concentration of acetylcholine in vivo can be increased.
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
DIC CORPORATION (Japon)
Inventeur(s)
Sato, Takayuki
Abrégé
[Problem] To accurately check a usage status of a medical product such as a damage status of the medical product or existence or nonexistence of the medical product. [Solution] A medical product (80) is configured to include a light-emissive septum (83) (constituent member) which includes a luminescent agent emitting near-infrared fluorescence according to irradiation of excitation light on a surface thereof. Even in a case where a portion of the septum is separated as a core (83a) (separate piece) due to damage, the luminescent agent is also included on a surface of the core. A medical product usage status checking apparatus (10) is configured to include a medical product which emits the near-infrared fluorescence, an irradiation unit (130) which irradiates the medical product with excitation light which excites the luminescent agent, an optical filter (140) which blocks the excitation light and transmits the near-infrared fluorescence emitted by the luminescent agent, a camera (15) (imaging unit) which receives the near-infrared fluorescence passing through the optical filter, and a monitor (160) (display unit) which displays an image captured by the camera. An image based on the near-infrared fluorescence of the septum is displayed on the monitor and in a case where damage occurs in the septum, an image based on the near-infrared fluorescence of the core is displayed on the monitor.
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Sato, Takayuki
Ike, Tatsumi
Abrégé
Provided are: an artery visualization device (10) that can suitably visualize an artery on which a puncture is to be performed; and an artery imaging device (60) used in said artery visualization device. The artery visualization device (10) has the following: an illumination unit (30) that shines near-infrared light, emitted by a light source (32), toward the rear skin surface (22) of a visualization site (20) through which the artery (21) to be punctured runs; a light-guiding part (40) that encapsulates the light source, is pressed against the rear skin surface, and is formed from a material that transmits the near-infrared light emitted from the light source but reduces reflection of the near-infrared light from the rear skin surface; an optical filter (50) that blocks visible light but transmits near-infrared light that has passed through the front skin surface (23) of the visualization site; a camera (60) that images the visualization site by receiving near-infrared light that has passed through the optical filter; and a monitor (70) that displays the image taken by the camera.
A61B 5/103 - Dispositifs de mesure pour le contrôle de la forme, du dessin, de la dimension ou du mouvement du corps ou de parties de celui-ci, à des fins de diagnostic
A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras
88.
MEDICAL PRODUCT THAT EMITS NEAR-INFRARED FLUORESCENCE AND MEDICAL-PRODUCT USAGE-STATUS ASCERTAINMENT DEVICE
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
DIC CORPORATION (Japon)
Inventeur(s)
Sato, Takayuki
Abrégé
[Problem] To make it possible to reliably ascertain the usage status of a medical product, e.g. the damage status of said medical product or the presence or absence of said medical product. [Solution] A medical product (80) is provided with a light-emission-capable septum (83) (constituent member), the surface of which contains a light-emitting agent that emits near-infrared fluorescence upon being illuminated with excitation light. Even if part of the septum detaches due to damage, forming a core (83a) (detached fragment), the surface of said core also contains the light-emitting agent. This medical-product usage-status ascertainment device (10) has the following: the aforementioned medical product that emits near-infrared fluorescence; an illumination unit (130) that shines, toward said medical product, excitation light that excites the light-emitting agent; an optical filter (140) that blocks the excitation light but transmits the near-infrared fluorescence emitted by the light-emitting agent; a camera (150) (imaging unit) that receives near-infrared fluorescence that has passed through the optical filter; and a monitor (160) (display unit) that displays images taken by the camera. The monitor displays an image based on near-infrared fluorescence from the septum, and if the septum has been damaged, displays an image based on near-infrared fluorescence from the core.
A61B 19/00 - Instruments, outillage ou accessoires pour la chirurgie ou le diagnostic non couverts par l'un des groupes A61B 1/00-A61B 18/00, p.ex. pour stéréotaxie, opération aseptique, traitement de la luxation, protecteurs des bords des blessures(masques de protection du visage A41D 13/11; blouses de chirurgien ou vêtements pour malades A41D 13/12; dispositifs pour retirer, traiter ou transporter les liquides du corps A61M 1/00)
89.
MODIFICATION OF HELPER T CELL-INDUCING POLYPEPTIDE
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Udaka, Keiko
Abrégé
The invention provides a tumor antigen-specific Th-inducing polypeptide capable of efficient antigen presentation, and an antitumor agent using the same.
A61K 39/245 - Herpetoviridae, p. ex. virus de l'Herpès simplex
A61K 39/39 - Préparations médicinales contenant des antigènes ou des anticorps caractérisées par les additifs immunostimulants, p. ex. par les adjuvants chimiques
A61P 1/16 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des troubles de la vésicule biliaire ou du foie, p. ex. protecteurs hépatiques, cholagogues, cholélitholytiques
A61P 1/18 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des troubles pancréatiques, p. ex. enzymes pancréatiques
A61P 3/10 - Médicaments pour le traitement des troubles du métabolisme de l'homéostase du glucose de l'hyperglycémie, p. ex. antidiabétiques
A61P 19/02 - Médicaments pour le traitement des troubles du squelette des troubles articulaires, p. ex. arthrites, arthroses
A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Nishitani, Shinobu
Hanazaki, Kazuhiro
Saibara, Toshiji
Abrégé
The purpose of the present invention is to provide a highly effective therapeutic agent for pancreatic cancer and/or biliary tract cancer. A therapeutic agent for pancreatic cancer and/or biliary tract cancer, comprising the following components (1) and (2) as essential components: (1) at least one branched amino acid selected from the group consisting of isoleucine, leucine and valine; and (2) gemcitabine or a salt thereof.
A61K 31/198 - Alpha-amino-acides, p. ex. alanine ou acide édétique [EDTA]
A61K 31/513 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime ayant des groupes oxo liés directement à l'hétérocycle, p. ex. cytosine
A61K 31/7068 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p. ex. nucléosides, nucléotides contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle contenant des pyrimidines condensées ou non-condensées ayant des groupes oxo liés directement au cycle pyrimidine, p. ex. cytidine, acide cytidylique
A61K 45/00 - Préparations médicinales contenant des ingrédients actifs non prévus dans les groupes
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Tanaka, Tohru
Tsuchiya, Kyoko
Ishizuka, Masahiro
Nakajima, Motowo
Nakagawa, Hitoshi
Shuin, Taro
Inoue, Keiji
Fukuhara, Hideo
Tsuda, Masayuki
Furihata, Mutsuo
Abrégé
[Problem] To provide a prophylactic agent and/or a treatment agent for side effects of cancer drugs. [Solution] This invention provides a prophylactic agent and/or a treatment agent for side effects of cancer drugs which contains ALA substances.
A61K 31/197 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe amino les groupes amino et carboxyle étant liés à la même chaîne carbone acyclique, p. ex. acide gamma-aminobutyrique [GABA], bêta-alanine, acide epsilon-aminocaproïque ou acide pantothénique
National University Corporation Kochi University (Japon)
Inventeur(s)
Inoue, Keiji
Shuin, Taro
Furihata, Mutsuo
Hirao, Yoshihiko
Tanaka, Tohru
Abrégé
It is to provide a method for detecting urothelial cancer simply and with high accuracy. It is a method for detecting urothelial cancer comprising administering 5-aminolevulinic acid (ALA), a derivative thereof, or a salt of these to a test subject, collecting urine from the test subject, and detecting the presence of fluorescence or amount of fluorescence in the collected urine.
G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
National University Corporation Kochi University (Japon)
Inventeur(s)
Sato Takayuki
Noguchi Katsumi
Abrégé
The medical tool position-confirming system is provided with: a luminescent medical tool (1) with a luminescent agent, which emits fluorescence as a result of being irradiating with near infrared light of 600 nm - 1400 nm wavelength, coated on or kneaded into the surface; a light source (3) that irradiates the near infrared light (2) towards the medical tool (1); a camera (4) that receives the near infrared fluorescence emitted by the luminescent agent of the medical tool (1); and a monitor (6) that projects the image (5) taken by the camera (4). The position of medical tools such as shunt tubes and the like can be confirmed without the use of X-rays.
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
A61B 5/06 - Dispositifs autres que ceux à radiation, pour détecter ou localiser les corps étrangers
A61B 19/00 - Instruments, outillage ou accessoires pour la chirurgie ou le diagnostic non couverts par l'un des groupes A61B 1/00-A61B 18/00, p.ex. pour stéréotaxie, opération aseptique, traitement de la luxation, protecteurs des bords des blessures(masques de protection du visage A41D 13/11; blouses de chirurgien ou vêtements pour malades A41D 13/12; dispositifs pour retirer, traiter ou transporter les liquides du corps A61M 1/00)
A61F 2/82 - Dispositifs maintenant le passage ou évitant l’affaissement de structures tubulaires du corps, p. ex. stents
A61L 29/00 - Matériaux pour cathéters ou pour revêtement de cathéters
A61L 31/00 - Matériaux pour autres articles chirurgicaux
A61M 1/00 - Dispositifs de succion ou de pompage à usage médicalDispositifs pour retirer, traiter ou transporter les liquides du corpsSystèmes de drainage
National University Corporation Kochi University (Japon)
Inventeur(s)
Inoue, Keiji
Shuin, Taro
Furihata, Mutsuo
Hirao, Yoshihiko
Tanaka, Tohru
Abrégé
Disclosed is a method for ditecting urothelial cancer in a simple manner and with high accuracy. Specifically disclosed is a method for detecting urothelial cancer, which comprises administering 5-aminolevulinic acid (ALA), a derivative thereof, or a salt of the compound or the derivative to a subject, collecting urine from the subject, and determining the presence or amount of a fluorescence in a cell contained in the urine collected from the subject.
G01N 33/48 - Matériau biologique, p. ex. sang, urineHémocytomètres
G01N 33/493 - Analyse physique de matériau biologique de matériau biologique liquide d'urine
G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
95.
IMAGING DEVICE, IMAGING DEVICE CONTROL METHOD, AND IMAGING DEVICE CONTROL PROGRAM
National University Corporation Kochi University (Japon)
SANYO Semiconductor Co., Ltd. (Japon)
MIZUHO IKAKOGYO CO., LTD. (Japon)
Inventeur(s)
Sato Takayuki
Kojima Kazuaki
Noguchi Katsumi
Abrégé
Provided is a fluorescent endoscopic device or the like that does not require an optical filter and does not require special image signal processing for the purpose of color correction. In the structure of the device equipped with an excitation light radiation means (1), a radiation means drive means (3), a photoelectric conversion means (8) that converts fluorescent light generated by living tissue into an electrical signal, a photoelectric conversion element drive means (6) that determines the drive timing for the photoelectric conversion means (8), and a stored charge reset means (6) that resets a charge stored in the photoelectric conversion means (8), the excitation light radiation means (1) is driven intermittently, and when the excitation light radiation means (1) is not being driven, the photoelectric conversion element drive means (6) drives the photoelectric conversion means (6) to perform photoelectric conversion.
A61B 1/04 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments combinés avec des dispositifs photographiques ou de télévision
A61B 1/00 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Udaka, Keiko
Ishibashi, Masahide
Abrégé
The present invention provides an adjuvant for cancer antigen peptide vaccines and virus antigen peptides, containing a pertussis vaccine as a primary ingredient. The present invention also provides a therapeutic agent for a cancer or viral infectious disease, and a prophylactic agent for metastasis or recurrence of cancer or onset of virus-induced tumor, containing a cancer antigen peptide or virus antigen peptide and a pertussis vaccine. A pertussis vaccine that can be suitably used is a whole cell body pertussis vaccine. The agents of the present invention can be safely administered in a plurality of doses.
A61K 39/10 - BrucellaBordetella, p. ex. Bordetella pertussis
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
A61K 39/04 - Mycobacterium, p. ex. Mycobacterium tuberculosis
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
National University Corporation KAGAWA UNIVERSITY (Japon)
National University Corporation KOCHI UNIVERSITY (Japon)
Inventeur(s)
Hasui, Kazumori
Hasui, Yuta
Yamauci, Kohen
Fukada, Haruhisa
Abrégé
A mixture of fermented artemisia with ginger is used for promoting the growth of animals or humans and promoting body weight gain in animals and humans to thereby increase livestock raising earnings and keep humans in good health. The mixture of fermented artemisia with ginger is prepared by fermenting artemisia with the use of one or more kinds of fermenting microorganisms selected from among a lactic acid bacterium, a yeast, a photosynthetic bacterium, an actinomycete, a thermophilic batch, koji mold and Bacillus natto and adding the fermented artemisia liquor thus obtained to ginger. The mixture of fermented artemisia withginger is added in an amount of 0.5 to 2.0% by weight to a feed or a food. Thus, it becomes possible to promote the growth of animals or humans and promote body weight gain in animals and humans to thereby increase livestock raising earnings and keep humans in good health.
A61K 36/28 - Asteraceae ou Compositae (famille de l'aster ou du tournesol), p. ex. camomille, chrysanthème matricaire, achillée ou echinacée
A61P 3/02 - Nutriments, p. ex. vitamines, minéraux
98.
FINE-PARTICLE COMPOSITE, PROCESS FOR PRODUCING THE FINE-PARTICLE COMPOSITE, CATALYST FOR SOLID POLYMER ELECTROLYTE FUEL CELL, AND SOLID POLYMER ELECTROLYTE FUEL CELL
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Kamiya, Sumio
Shou, Tatsuo
Kato, Yukinobu
Otake, Noboru
Kimura, Harumi
Yanagisawa, Kazumichi
Li, Nan
Zhang, Wuxing
Abrégé
This invention provides a process for producing a fine-particle composite comprising a fine particle of a sulfide or a composite sulfide of one or more elements selected from molybdenum (Mo), rhodium (Rh), ruthenium (Ru), and rhenium (Re) and electroconductive fine particles. The production process comprises the step of preparing a solvent mixed liquid from an electroconductive carbon powder, one or more compounds containing an element selected from molybdenum (Mo), rhodium (Rh), ruthenium (Ru), and rhenium (Re), and a compound containing sulfur (S), and the step of subjecting the solvent mixed liquid to a hydrothermal reaction or a solvothermal reaction at a pressure and a temperature that bring water or the solvent to a supercritical state or a subcritical state.
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY (Japon)
Inventeur(s)
Kamiya, Sumio
Shou, Tatsuo
Kato, Yukinobu
Otake, Noboru
Yanagisawa, Kazumichi
Zhang, Wuxing
Abrégé
This invention provides a fine particle composite comprising fine powder of a sulfide or sulfide complex comprising a given element. The fine particle composite is obtained by a method for producing a fine particle composite comprising fine powder of a sulfide or sulfide complex comprising at least one element selected from the group consisting of molybdenum (Mo), rhodium (Rh), ruthenium (Ru), and rhenium (Re). Such method comprises steps of: preparing a solvent mixture from at least one compound containing an element selected from among molybdenum (Mo), rhodium (Rh), ruthenium (Ru), rhenium (Re), and sulfur (S); and subjecting the solvent mixture to a hydrothermal or solvothermal reaction. The resulting fine particle composite comprises fine particles of a sulfide or sulfide complex comprising at least one element selected from the group consisting of molybdenum (Mo), rhodium (Rh), ruthenium (Ru), and rhenium (Re).
National University Corporation Kochi University (Japon)
DAICEL CHEMICAL INDUSTRIES, LTD. (Japon)
DAIICHI SEIMO CO., LTD. (Japon)
Inventeur(s)
Oshima, Syunichirou
Matsuda, Hirokazu
Okuzono, Kazuhiko
Abrégé
As an agent which is less expensive, highly safe and effective for exterminating pathogenic bacteria in fishes, for example, pathogenic bacteria causing gliding bacterial disease in Seriola quinqueradiata, Pagrus major or Paralichthys olivaceus, fishes parasitized with pathogenic bacteria are treated with an agent comprising an organic acid as the main component. Thus, the pathogenic bacteria are safely and effectively controlled and exterminated.