The present disclosure provides deuterated compounds and their use as sodium channel blockers in the treatment or prevention of various diseases or disorders associated with sodium channels.
C07D 417/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
A61K 31/635 - Composés contenant des groupes para-N-benzènesulfonyl-N-, p. ex. sulfanilamide, p-nitrobenzènesulfonohydrazide contenant un hétérocycle, p. ex. sulfadiazine
C07B 59/00 - Introduction d'isotopes d'éléments dans les composés organiques
2.
SUBSTITUTED PYRIDO[2,1-a]ISOQUINOLINES AS VMAT2 INHIBITORS
This disclosure relates generally to VMAT2 inhibitor compounds of Formula (Ia):
This disclosure relates generally to VMAT2 inhibitor compounds of Formula (Ia):
This disclosure relates generally to VMAT2 inhibitor compounds of Formula (Ia):
and pharmaceutically acceptable salts thereof, as well as compositions and methods related thereto.
e.g.e.g.e.g., about 1 mg QD or about 3 mg QD), pharmaceutical compositions for use in the once-daily treatment of cognition associated with certain disorders, and uses of COMPOUND A in the preparation of the same.
A61K 31/542 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec au moins un azote et au moins un soufre comme hétéro-atomes d'un cycle, p. ex. sulthiame condensés en ortho ou en péri avec des systèmes hétérocycliques
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 47/00 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif
A61P 25/18 - Antipsychotiques, c.-à-d. neuroleptiquesMédicaments pour le traitement de la manie ou de la schizophrénie
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
A61K 31/135 - Amines, p. ex. amantadine ayant des cycles aromatiques, p. ex. méthadone
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
4.
METHODS OF ADMINISTERING 9-[4-(CYCLOHEXYLOXY)PHENYL]-7-METHYL-3,4-DIHYDROPYRAZINO[2,1-C][1,2,4]THIADIAZINE 2,2-DIOXIDE WITHOUT SIDE EFFECTS
Methods of treating depressive disorders and cognitive impairment in a patient in need thereof comprising administering to the patient 9-[4-(cyclohexyloxy)phenyl]-7-methyl-3,4-dihydropyrazino[2,1-c][1,2,4]thiadiazine2,2-dioxide ("COMPOUND A") in an amount of from about 1 mg to about 3 mg once daily, pharmaceutical compositions, and uses of COMPOUND A are disclosed. Also disclosed are methods of administering COMPOUND A to a patient, with the administration of COMPOUND A not causing the patient to experience a substantial increase in seizures, not causing a substantial increase in the patient's body weight, and/or not causing the patient to experience a substantial increase in a psychotomimetic and/or a dissociative event.
This disclosure provides corticotropin releasing factor receptor 2 (CRFR2) agonist peptides, pharmaceutical compositions comprising such peptides, and methods of using such peptides to treat and/or prevent, for example, cardiovascular diseases, obesity, diabetes, sarcopenia, cachexia, kidney disease, heart failure and pulmonary hypertension.
09 - Appareils et instruments scientifiques et électriques
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Downloadable podcasts in the field of health, pharmaceuticals, and medicine; downloadable podcasts in the field of Congenital Adrenal Hyperplasia (CAH) and other medical conditions Production of podcasts; providing podcasts in the field of health, pharmaceuticals, and medicine; providing podcasts in the field of Congenital Adrenal Hyperplasia (CAH) and other medical conditions
09 - Appareils et instruments scientifiques et électriques
16 - Papier, carton et produits en ces matières
35 - Publicité; Affaires commerciales
38 - Services de télécommunications
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Downloadable children's books; downloadable children's
booklets; downloadable children's activity books;
downloadable newsletters; downloadable computer software
games. Printed children's books; printed children's booklets;
printed activity books; printed newsletters in the field of
endocrine diseases and disorders. Administering a patient support program to coordinate access
to medicines; administering a patient support program to
provide pharmaceutical co-pay assistance; administering a
patient support program to provide general education and
support and information about available resources for
patients, caregivers and healthcare providers; administering
a patient support program to provide and assist with
insurance coverage and reimbursement information; promoting
awareness of congenital adrenal hyperplasia including via a
public platform to discuss congenital adrenal hyperplasia
and coping strategies; promoting awareness of adrenal
insufficiency including via a public platform to discuss
adrenal insufficiency and coping strategies; promoting
awareness of endocrine diseases and disorders including via
a public platform to discuss endocrine diseases and
disorders and coping strategies; promoting the interests of
people who have congenital adrenal hyperplasia and their
families and health care providers by means of public
advocacy; promoting the interests of people who have adrenal
insufficiency and their families and health care providers
by means of public advocacy; promoting the interests of
people who have endocrine diseases and disorders and their
families and health care providers by means of public
advocacy; maintaining a registry of patients with congenital
adrenal hyperplasia; maintaining a registry of patients with
adrenal insufficiency; maintaining a registry of patients
with endocrine diseases and disorders; updating and
maintenance of information in registries, namely,
administering a patient registry for patients with
congenital adrenal hyperplasia; updating and maintenance of
information in registries, namely, administering a patient
registry for patients with adrenal insufficiency; updating
and maintenance of information in registries, namely,
administering a patient registry for patients with endocrine
diseases and disorders. Providing an online forum in the field of health and
pharmaceuticals. Educational services; providing mentorship programs in the
field of health and pharmaceuticals; providing an in-person
health forum for users to participate in discussions in the
field of congenital adrenal hyperplasia; providing an
in-person health forum for users to participate in
discussions in the field of adrenal insufficiency; providing
an in-person health forum for users to participate in
discussions in the field of endocrine diseases and
disorders. Providing information about medical research; providing
medical research information in the field of pharmaceuticals
and congenital adrenal hyperplasia; providing medical
research information in the field of pharmaceuticals and
adrenal insufficiency; providing medical research
information in the field of pharmaceuticals and endocrine
diseases and disorders; creating an online community for
users for the purpose of participating in discussions in the
fields of health, pharmaceuticals, and coping strategies. Providing medical information; providing medical information
to patients, medical professionals, and insurance companies
in the field of congenital adrenal hyperplasia; providing
medical information to patients, medical professionals, and
insurance companies in the field of adrenal insufficiency;
providing medical information to patients, medical
professionals, and insurance companies in the field of
endocrine diseases and disorders; online information
services, namely, providing medical information in the field
of congenital adrenal hyperplasia; online information
services, namely, providing medical information in the field
of adrenal insufficiency; online information services,
namely, providing medical information in the field of
endocrine diseases and disorders.
09 - Appareils et instruments scientifiques et électriques
16 - Papier, carton et produits en ces matières
35 - Publicité; Affaires commerciales
38 - Services de télécommunications
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Downloadable children's books; downloadable children's
booklets; downloadable children's activity books;
downloadable newsletters; downloadable computer software
games. Printed children's books; printed children's booklets;
printed activity books; printed newsletters in the field of
endocrine diseases and disorders. Administering a patient support program to coordinate access
to medicines; administering a patient support program to
provide pharmaceutical co-pay assistance; administering a
patient support program to provide general education and
support and information about available resources for
patients, caregivers and healthcare providers; administering
a patient support program to provide and assist with
insurance coverage and reimbursement information; promoting
awareness of congenital adrenal hyperplasia including via a
public platform to discuss congenital adrenal hyperplasia
and coping strategies; promoting awareness of adrenal
insufficiency including via a public platform to discuss
adrenal insufficiency and coping strategies; promoting
awareness of endocrine diseases and disorders including via
a public platform to discuss endocrine diseases and
disorders and coping strategies; promoting the interests of
people who have congenital adrenal hyperplasia and their
families and health care providers by means of public
advocacy; promoting the interests of people who have adrenal
insufficiency and their families and health care providers
by means of public advocacy; promoting the interests of
people who have endocrine diseases and disorders and their
families and health care providers by means of public
advocacy; maintaining a registry of patients with congenital
adrenal hyperplasia; maintaining a registry of patients with
adrenal insufficiency; maintaining a registry of patients
with endocrine diseases and disorders; updating and
maintenance of information in registries, namely,
administering a patient registry for patients with
congenital adrenal hyperplasia; updating and maintenance of
information in registries, namely, administering a patient
registry for patients with adrenal insufficiency; updating
and maintenance of information in registries, namely,
administering a patient registry for patients with endocrine
diseases and disorders. Providing an online forum in the field of health and
pharmaceuticals. Educational services; providing mentorship programs in the
field of health and pharmaceuticals; providing an in-person
health forum for users to participate in discussions in the
field of congenital adrenal hyperplasia; providing an
in-person health forum for users to participate in
discussions in the field of adrenal insufficiency; providing
an in-person health forum for users to participate in
discussions in the field of endocrine diseases and
disorders. Providing information about medical research; providing
medical research information in the field of pharmaceuticals
and congenital adrenal hyperplasia; providing medical
research information in the field of pharmaceuticals and
adrenal insufficiency; providing medical research
information in the field of pharmaceuticals and endocrine
diseases and disorders; creating an online community for
users for the purpose of participating in discussions in the
fields of health, pharmaceuticals, and coping strategies. Providing medical information; providing medical information
to patients, medical professionals, and insurance companies
in the field of congenital adrenal hyperplasia; providing
medical information to patients, medical professionals, and
insurance companies in the field of adrenal insufficiency;
providing medical information to patients, medical
professionals, and insurance companies in the field of
endocrine diseases and disorders; online information
services, namely, providing medical information in the field
of congenital adrenal hyperplasia; online information
services, namely, providing medical information in the field
of adrenal insufficiency; online information services,
namely, providing medical information in the field of
endocrine diseases and disorders.
inter aliainter alia, certain compounds, compositions, and pharmaceutical compositions thereof, that modulate the activity of the transporter protein vesicular monoamine transporter- 2 (VMAT2) and are directed to methods useful in the treatment of transporter protein vesicular monoamine transporter-2 mediated disorders, such as, neurological or psychiatric disease or disorders, including but not limited to, hyperkinetic movement disorders (e.g., tardive dyskinesia, Tourette's syndrome, Huntington's disease, tics, ataxia, chorea (such as, chorea associated with Huntington's disease), dystonia, hemifacial spasm, myoclonus, restless leg syndrome, and tremors). The disclosure further relates to synthetic methods and intermediates useful in the preparation of compounds.
A61K 31/4375 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à six chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. quinolizines, naphtyridines, berbérine, vincamine
A61P 25/14 - Médicaments pour le traitement des troubles du système nerveux pour traiter les mouvements anormaux, p. ex. chorée, dyskinésie
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
Printed questionnaires in the nature of assessments in the field of healthcare; printed questionnaires in the nature of assessments in the field of tardive dyskinesia.
12.
METHODS FOR THE ADMINISTRATION OF CERTAIN VMAT2 INHIBITORS
A61P 25/14 - Médicaments pour le traitement des troubles du système nerveux pour traiter les mouvements anormaux, p. ex. chorée, dyskinésie
A61K 31/4745 - QuinoléinesIsoquinoléines condensées en ortho ou en péri avec des systèmes hétérocycliques condensées avec des systèmes cycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. phénanthrolines
13.
GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO
GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure:
GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure:
GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure:
wherein R1a, R1b, R1c, R1d, R2, R2a, and A are as defined herein, including stereoisomers, esters, solvates and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
C07C 233/88 - Amides d'acides carboxyliques ayant des atomes d'azote de groupes carboxamide liés à un atome de carbone acyclique et à un atome de carbone d'un cycle aromatique à six chaînons dans lequel au moins un atome d'hydrogène en ortho a été remplacé
C07C 235/42 - Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des atomes d'oxygène ayant des atomes de carbone de groupes carboxamide liés à des atomes de carbone de cycles aromatiques à six chaînons et des atomes d'oxygène, liés par des liaisons simples, liés au même squelette carboné
C07C 255/57 - Nitriles d'acides carboxyliques ayant des groupes cyano liés à des atomes de carbone de cycles aromatiques à six chaînons d'un squelette carboné contenant des groupes cyano et des groupes carboxyle, autres que des groupes cyano, liés au squelette carboné
C07D 213/89 - Composés hétérocycliques contenant des cycles à six chaînons, non condensés avec d'autres cycles, ne comportant qu'un atome d'azote comme unique hétéro-atome du cycle et avec au moins trois doubles liaisons entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques comportant trois liaisons doubles avec des hétéro-atomes liés directement à l'atome d'azote du cycle
C07D 215/14 - Radicaux substitués par des atomes d'oxygène
C07D 215/54 - Atomes de carbone comportant trois liaisons à des hétéro-atomes avec au plus une liaison à un halogène liés en position 3
C07D 239/36 - Un atome d'oxygène lié par une liaison double ou sous forme de radical hydroxyle non substitué
C07D 401/04 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 413/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 417/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
09 - Appareils et instruments scientifiques et électriques
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Downloadable podcasts in the field of health, pharmaceuticals, and medicine; downloadable podcasts in the field of Congenital Adrenal Hyperplasia (CAH) and other medical conditions Production of podcasts; providing podcasts in the field of health, pharmaceuticals, and medicine; providing podcasts in the field of Congenital Adrenal Hyperplasia (CAH) and other medical conditions
05 - Produits pharmaceutiques, vétérinaires et hygièniques
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical preparations for human use; pharmaceutical preparations for the treatment of neurological, central nervous system, psychiatric and movement diseases, disorders and conditions; pharmaceutical preparations for the treatment of tardive dyskinesia; pharmaceutical preparations for the treatment of Huntington's Disease and chorea associated with Huntington's Disease Providing medical information; providing medical information in the field of neurological, central nervous system, psychiatric and movement diseases, disorders, and conditions; providing medical information in the field of tardive dyskinesia; providing medical information in the field of Huntington's Disease and chorea associated with Huntington's Disease
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical research and development services; conducting
clinical trials for pharmaceutical preparations;
pharmaceutical research services and pharmaceutical product
evaluation, namely, conducting post-authorization research
for the marketing of pharmaceutical preparations and
evaluating epidemiological results; pharmaceutical research
and development services in the field of anhedonia, major
depressive disorder and mood disorders; conducting clinical
trials for others for pharmaceutical preparations for the
treatment and prevention of anhedonia, major depressive
disorder and mood disorders; pharmaceutical research
services and pharmaceutical product evaluation, namely,
conducting post-authorization research for the marketing of
pharmaceutical preparations for the treatment and prevention
of anhedonia, major depressive disorder and mood disorders,
and evaluating epidemiological results for treatments for
anhedonia, major depressive disorder and mood disorders;
providing medical and scientific research information to
patients and practitioners in the field of clinical trials,
namely, as to the results of clinical trials; providing
medical and scientific research information to patients and
practitioners in the field of clinical trials, namely, as to
the results of clinical trials pertaining to therapies and
treatments for anhedonia, major depressive disorder and mood
disorders. Providing medical information; providing medical information
relating to therapies and treatments for anhedonia, major
depressive disorder and mood disorders.
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical research and development services; conducting
clinical trials for pharmaceutical preparations;
pharmaceutical research services and pharmaceutical product
evaluation, namely, conducting post-authorization research
for the marketing of pharmaceutical preparations and
evaluating epidemiological results; pharmaceutical research
and development services in the field of anhedonia, major
depressive disorder and mood disorders; conducting clinical
trials for others for pharmaceutical preparations for the
treatment and prevention of anhedonia, major depressive
disorder and mood disorders; pharmaceutical research
services and pharmaceutical product evaluation, namely,
conducting post-authorization research for the marketing of
pharmaceutical preparations for the treatment and prevention
of anhedonia, major depressive disorder and mood disorders,
and evaluating epidemiological results for treatments for
anhedonia, major depressive disorder and mood disorders;
providing medical and scientific research information to
patients and practitioners in the field of clinical trials,
namely, as to the results of clinical trials; providing
medical and scientific research information to patients and
practitioners in the field of clinical trials, namely, as to
the results of clinical trials pertaining to therapies and
treatments for anhedonia, major depressive disorder and mood
disorders. Providing medical information; providing medical information
relating to therapies and treatments for anhedonia, major
depressive disorder and mood disorders.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical preparations for the treatment of adrenal
insufficiency; pharmaceutical preparations for the treatment
of hormonal and genetic diseases, disorders and conditions;
pharmaceutical preparations for the diagnosis, prevention
and treatment of endocrine diseases and disorders;
pharmaceutical preparations for the treatment of congenital
adrenal hyperplasia; pharmaceuticals for the treatment of
rare and orphan hormonal and genetic diseases, disorders and
conditions. Providing medical research information; providing medical
research information in the field of pharmaceuticals and
clinical trials focusing on congenital adrenal hyperplasia
and other endocrine diseases and disorders; scientific
research in the nature of conducting clinical trials for
pharmaceutical preparations for the treatment of congenital
adrenal hyperplasia and other endocrine diseases and
disorders, for others; conducting post-authorization
pharmaceutical research for the marketing of pharmaceutical
preparations and evaluating epidemiological results. Providing medical information; providing medical information
to patients, medical professionals, and insurance companies
in the field of congenital adrenal hyperplasia and other
endocrine diseases and disorders; on-line information
services, namely, providing medical information to patients,
medical professionals, and insurance companies in the field
of congenital adrenal hyperplasia and other endocrine
diseases and disorders.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical preparations for the treatment of adrenal
insufficiency; pharmaceutical preparations for the treatment
of hormonal and genetic diseases, disorders and conditions;
pharmaceutical preparations for the diagnosis, prevention
and treatment of endocrine diseases and disorders;
pharmaceutical preparations for the treatment of congenital
adrenal hyperplasia; pharmaceuticals for the treatment of
rare and orphan hormonal and genetic diseases, disorders and
conditions. Providing medical research information; providing medical
research information in the field of pharmaceuticals and
clinical trials focusing on congenital adrenal hyperplasia
and other endocrine diseases and disorders; scientific
research in the nature of conducting clinical trials for
pharmaceutical preparations for the treatment of congenital
adrenal hyperplasia and other endocrine diseases and
disorders, for others; conducting post-authorization
pharmaceutical research for the marketing of pharmaceutical
preparations and evaluating epidemiological results. Providing medical information; providing medical information
to patients, medical professionals, and insurance companies
in the field of congenital adrenal hyperplasia and other
endocrine diseases and disorders; on-line information
services, namely, providing medical information to patients,
medical professionals, and insurance companies in the field
of congenital adrenal hyperplasia and other endocrine
diseases and disorders.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical preparations for the treatment of adrenal
insufficiency; pharmaceutical preparations for the treatment
of hormonal and genetic diseases, disorders and conditions;
pharmaceutical preparations for the diagnosis, prevention
and treatment of endocrine diseases and disorders;
pharmaceutical preparations for the treatment of congenital
adrenal hyperplasia; pharmaceuticals for the treatment of
rare and orphan hormonal and genetic diseases, disorders and
conditions. Providing medical research information; providing medical
research information in the field of pharmaceuticals and
clinical trials focusing on congenital adrenal hyperplasia
and other endocrine diseases and disorders; scientific
research in the nature of conducting clinical trials for
pharmaceutical preparations for the treatment of congenital
adrenal hyperplasia and other endocrine diseases and
disorders, for others; conducting post-authorization
pharmaceutical research for the marketing of pharmaceutical
preparations and evaluating epidemiological results. Providing medical information; providing medical information
to patients, medical professionals, and insurance companies
in the field of congenital adrenal hyperplasia and other
endocrine diseases and disorders; on-line information
services, namely, providing medical information to patients,
medical professionals, and insurance companies in the field
of congenital adrenal hyperplasia and other endocrine
diseases and disorders.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical preparations for the treatment of adrenal
insufficiency; pharmaceutical preparations for the treatment
of hormonal and genetic diseases, disorders and conditions;
pharmaceutical preparations for the diagnosis, prevention
and treatment of endocrine diseases and disorders;
pharmaceutical preparations for the treatment of congenital
adrenal hyperplasia; pharmaceuticals for the treatment of
rare and orphan hormonal and genetic diseases, disorders and
conditions. Providing medical research information; providing medical
research information in the field of pharmaceuticals and
clinical trials focusing on congenital adrenal hyperplasia
and other endocrine diseases and disorders; scientific
research in the nature of conducting clinical trials for
pharmaceutical preparations for the treatment of congenital
adrenal hyperplasia and other endocrine diseases and
disorders, for others; conducting post-authorization
pharmaceutical research for the marketing of pharmaceutical
preparations and evaluating epidemiological results. Providing medical information; providing medical information
to patients, medical professionals, and insurance companies
in the field of congenital adrenal hyperplasia and other
endocrine diseases and disorders; on-line information
services, namely, providing medical information to patients,
medical professionals, and insurance companies in the field
of congenital adrenal hyperplasia and other endocrine
diseases and disorders.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical preparations for the treatment of adrenal
insufficiency; pharmaceutical preparations for the treatment
of hormonal and genetic diseases, disorders and conditions;
pharmaceutical preparations for the diagnosis, prevention
and treatment of endocrine diseases and disorders;
pharmaceutical preparations for the treatment of congenital
adrenal hyperplasia; pharmaceuticals for the treatment of
rare and orphan hormonal and genetic diseases, disorders and
conditions. Providing medical research information; providing medical
research information in the field of pharmaceuticals and
clinical trials focusing on congenital adrenal hyperplasia
and other endocrine diseases and disorders; scientific
research in the nature of conducting clinical trials for
pharmaceutical preparations for the treatment of congenital
adrenal hyperplasia and other endocrine diseases and
disorders, for others; conducting post-authorization
pharmaceutical research for the marketing of pharmaceutical
preparations and evaluating epidemiological results. Providing medical information; providing medical information
to patients, medical professionals, and insurance companies
in the field of congenital adrenal hyperplasia and other
endocrine diseases and disorders; on-line information
services, namely, providing medical information to patients,
medical professionals, and insurance companies in the field
of congenital adrenal hyperplasia and other endocrine
diseases and disorders.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical preparations for the treatment of adrenal
insufficiency; pharmaceutical preparations for the treatment
of hormonal and genetic diseases, disorders and conditions;
pharmaceutical preparations for the diagnosis, prevention
and treatment of endocrine diseases and disorders;
pharmaceutical preparations for the treatment of congenital
adrenal hyperplasia; pharmaceuticals for the treatment of
rare and orphan hormonal and genetic diseases, disorders and
conditions. Providing medical research information; providing medical
research information in the field of pharmaceuticals and
clinical trials focusing on congenital adrenal hyperplasia
and other endocrine diseases and disorders; scientific
research in the nature of conducting clinical trials for
pharmaceutical preparations for the treatment of congenital
adrenal hyperplasia and other endocrine diseases and
disorders, for others; conducting post-authorization
pharmaceutical research for the marketing of pharmaceutical
preparations and evaluating epidemiological results. Providing medical information; providing medical information
to patients, medical professionals, and insurance companies
in the field of congenital adrenal hyperplasia and other
endocrine diseases and disorders; on-line information
services, namely, providing medical information to patients,
medical professionals, and insurance companies in the field
of congenital adrenal hyperplasia and other endocrine
diseases and disorders.
09 - Appareils et instruments scientifiques et électriques
41 - Éducation, divertissements, activités sportives et culturelles
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Downloadable educational course materials in the field of health, diseases and
disorders, and pharmaceuticals Educational services, namely, conducting online courses in the field of health,
diseases and disorders, and pharmaceuticals and distribution of course material in connection therewith Providing medical information
09 - Appareils et instruments scientifiques et électriques
41 - Éducation, divertissements, activités sportives et culturelles
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Downloadable educational course materials in the field of health, diseases and
disorders, and pharmaceuticals Educational services, namely, conducting online courses in the field of health,
diseases and disorders, and pharmaceuticals and distribution of course material in connection therewith Providing medical information
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical research and development services; conducting clinical trials for pharmaceutical preparations; pharmaceutical research services and pharmaceutical product evaluation, namely, conducting post-authorization research for the marketing of pharmaceutical preparations and evaluating epidemiological results; pharmaceutical research and development services in the field of anhedonia, major depressive disorder and mood disorders; conducting clinical trials for others for pharmaceutical preparations for the treatment and prevention of anhedonia, major depressive disorder and mood disorders; pharmaceutical research services and pharmaceutical product evaluation, namely, conducting post-authorization research for the marketing of pharmaceutical preparations for the treatment and prevention of anhedonia, major depressive disorder and mood disorders, and evaluating epidemiological results for treatments for anhedonia, major depressive disorder and mood disorders; providing medical and scientific research information to patients and practitioners in the field of clinical trials, namely, as to the results of clinical trials; providing medical and scientific research information to patients and practitioners in the field of clinical trials, namely, as to the results of clinical trials pertaining to therapies and treatments for anhedonia, major depressive disorder and mood disorders Providing medical information; providing medical information relating to therapies and treatments for anhedonia, major depressive disorder and mood disorders
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical research and development services; conducting clinical trials for pharmaceutical preparations; pharmaceutical research services and pharmaceutical product evaluation, namely, conducting post-authorization research for the marketing of pharmaceutical preparations and evaluating epidemiological results; pharmaceutical research and development services in the field of anhedonia, major depressive disorder and mood disorders; conducting clinical trials for others for pharmaceutical preparations for the treatment and prevention of anhedonia, major depressive disorder and mood disorders; pharmaceutical research services and pharmaceutical product evaluation, namely, conducting post-authorization research for the marketing of pharmaceutical preparations for the treatment and prevention of anhedonia, major depressive disorder and mood disorders, and evaluating epidemiological results for treatments for anhedonia, major depressive disorder and mood disorders; providing medical and scientific research information to patients and practitioners in the field of clinical trials, namely, as to the results of clinical trials; providing medical and scientific research information to patients and practitioners in the field of clinical trials, namely, as to the results of clinical trials pertaining to therapies and treatments for anhedonia, major depressive disorder and mood disorders Providing medical information; providing medical information relating to therapies and treatments for anhedonia, major depressive disorder and mood disorders
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical research and development services; conducting clinical trials for pharmaceutical preparations; pharmaceutical research services and pharmaceutical product evaluation, namely, conducting post-authorization research for the marketing of pharmaceutical preparations and evaluating epidemiological results; pharmaceutical research and development services in the field of anhedonia, major depressive disorder and mood disorders; conducting clinical trials for others for pharmaceutical preparations for the treatment and prevention of anhedonia, major depressive disorder and mood disorders; pharmaceutical research services and pharmaceutical product evaluation, namely, conducting post-authorization research for the marketing of pharmaceutical preparations for the treatment and prevention of anhedonia, major depressive disorder and mood disorders, and evaluating epidemiological results for treatments for anhedonia, major depressive disorder and mood disorders; providing medical and scientific research information to patients and practitioners in the field of clinical trials, namely, as to the results of clinical trials; providing medical and scientific research information to patients and practitioners in the field of clinical trials, namely, as to the results of clinical trials pertaining to therapies and treatments for anhedonia, major depressive disorder and mood disorders Providing medical information; providing medical information relating to therapies and treatments for anhedonia, major depressive disorder and mood disorders
09 - Appareils et instruments scientifiques et électriques
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Downloadable podcasts in the field of health, pharmaceuticals, and medicine; Downloadable podcasts in the field of tardive dyskinesia and other medical conditions Production of podcasts; Providing podcasts in the field of health, pharmaceuticals, and medicine; Providing podcasts in the field of tardive dyskinesia and other medical conditions
09 - Appareils et instruments scientifiques et électriques
41 - Éducation, divertissements, activités sportives et culturelles
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Downloadable educational course materials in the field of health, diseases and disorders, and pharmaceuticals Educational services, namely, conducting online courses in the field of health, diseases and disorders, and pharmaceuticals and distribution of course material in connection therewith Providing medical information
32.
Solid Pharmaceutical Formulations for Treating Endometriosis, Uterine Fibroids, Polycystic Ovary Syndrome or Adenomyosis
The present disclosure relates to pharmaceutical compositions comprising a gonadotropin-releasing hormone (GnRH) antagonist and methods of preparing and using such compositions. The disclosure also relates to methods of facilitating release of a GnRH antagonist from a pharmaceutical composition.
This disclosure provides fatty acid conjugated cyclic peptides, pharmaceutical compositions comprising such fatty acid conjugated cyclic peptides and methods of using such fatty acid conjugated cyclic peptides to treat or prevent diseases associated with the abnormal or dysregulated activity of corticotropin releasing factor (CRT) signaling.
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
(1) Pharmaceutical research and development services; conducting clinical trials for pharmaceutical preparations; pharmaceutical research services and pharmaceutical product evaluation, namely, conducting post-authorization research for the marketing of pharmaceutical preparations and evaluating epidemiological results; pharmaceutical research and development services in the field of anhedonia, major depressive disorder and mood disorders; conducting clinical trials for others for pharmaceutical preparations for the treatment and prevention of anhedonia, major depressive disorder and mood disorders; pharmaceutical research services and pharmaceutical product evaluation, namely, conducting post-authorization research for the marketing of pharmaceutical preparations for the treatment and prevention of anhedonia, major depressive disorder and mood disorders, and evaluating epidemiological results for treatments for anhedonia, major depressive disorder and mood disorders; providing medical and scientific research information to patients and practitioners in the field of clinical trials, namely, as to the results of clinical trials; providing medical and scientific research information to patients and practitioners in the field of clinical trials, namely, as to the results of clinical trials pertaining to therapies and treatments for anhedonia, major depressive disorder and mood disorders.
(2) Providing medical information; providing medical information relating to therapies and treatments for anhedonia, major depressive disorder and mood disorders.
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
(1) Pharmaceutical research and development services; conducting clinical trials for pharmaceutical preparations; pharmaceutical research services and pharmaceutical product evaluation, namely, conducting post-authorization research for the marketing of pharmaceutical preparations and evaluating epidemiological results; pharmaceutical research and development services in the field of anhedonia, major depressive disorder and mood disorders; conducting clinical trials for others for pharmaceutical preparations for the treatment and prevention of anhedonia, major depressive disorder and mood disorders; pharmaceutical research services and pharmaceutical product evaluation, namely, conducting post-authorization research for the marketing of pharmaceutical preparations for the treatment and prevention of anhedonia, major depressive disorder and mood disorders, and evaluating epidemiological results for treatments for anhedonia, major depressive disorder and mood disorders; providing medical and scientific research information to patients and practitioners in the field of clinical trials, namely, as to the results of clinical trials; providing medical and scientific research information to patients and practitioners in the field of clinical trials, namely, as to the results of clinical trials pertaining to therapies and treatments for anhedonia, major depressive disorder and mood disorders.
(2) Providing medical information; providing medical information relating to therapies and treatments for anhedonia, major depressive disorder and mood disorders.
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical research and development services; conducting clinical trials for others for pharmaceutical preparations; pharmaceutical research services and pharmaceutical product evaluation, namely, conducting post-authorization research for the marketing of pharmaceutical preparations and evaluating epidemiological results; pharmaceutical research and development services in the field of neurological, central nervous system, and movement diseases and disorders and tardive dyskinesia; conducting clinical trials for others for pharmaceutical preparations for the treatment and prevention of neurological, central nervous system, and movement diseases and disorders and tardive dyskinesia; providing medical and scientific research information to patients and practitioners in the field of clinical trials, namely, as to the results of clinical trials; providing medical and scientific research information to patients and practitioners in the field of clinical trials, namely, as to the results of clinical trials pertaining to therapies and treatments for neurological, central nervous system, and movement diseases and disorders and tardive dyskinesia; pharmaceutical research services and pharmaceutical product evaluation, namely, conducting post-authorization research for the marketing of pharmaceutical preparations for the treatment and prevention of neurological, central nervous system, and movement diseases and disorders and tardive dyskinesia, and evaluating epidemiological results for treatments for neurological, central nervous system, and movement diseases and disorders and tardive dyskinesia Providing medical information; providing medical information relating to therapies and treatments for neurological, central nervous system, and movement diseases and disorders and tardive dyskinesia
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Promoting awareness of congenital adrenal hyperplasia;
promoting awareness of adrenal insufficiency; promoting
awareness of endocrine diseases and disorders; promoting the
interests of people who have congenital adrenal hyperplasia
and their families and health care providers by means of
public advocacy; promoting the interests of people who have
adrenal insufficiency and their families and health care
providers by means of public advocacy; promoting the
interests of people who have endocrine diseases and
disorders and their families and health care providers by
means of public advocacy; maintaining a registry of patients
with congenital adrenal hyperplasia; maintaining a registry
of patients with adrenal insufficiency; maintaining a
registry of patients with endocrine diseases and disorders;
updating and maintenance of information in registries,
namely, administering a patient registry for patients with
congenital adrenal hyperplasia; updating and maintenance of
information in registries, namely, administering a patient
registry for patients with adrenal insufficiency; updating
and maintenance of information in registries, namely,
administering a patient registry for patients with endocrine
diseases and disorders. Providing an in-person health forum for users to participate
in discussions in the field of congenital adrenal
hyperplasia; providing an in-person health forum for users
to participate in discussions in the field of adrenal
insufficiency; providing an in-person health forum for users
to participate in discussions in the field of endocrine
diseases and disorders. Providing information about medical research; providing
medical research information in the field of pharmaceuticals
and congenital adrenal hyperplasia; providing medical
research information in the field of pharmaceuticals and
adrenal insufficiency; providing medical research
information in the field of pharmaceuticals and endocrine
diseases and disorders; providing a public platform to
discuss congenital adrenal hyperplasia and coping
strategies; providing a public platform to discuss adrenal
insufficiency and coping strategies; providing a public
platform to discuss endocrine diseases and disorders and
coping strategies. Providing medical information; providing medical information
to patients, medical professionals, and insurance companies
in the field of congenital adrenal hyperplasia; providing
medical information to patients, medical professionals, and
insurance companies in the field of adrenal insufficiency;
providing medical information to patients, medical
professionals, and insurance companies in the field of
endocrine diseases and disorders; online information
services, namely, providing medical information in the field
of congenital adrenal hyperplasia; online information
services, namely, providing medical information in the field
of adrenal insufficiency; online information services,
namely, providing medical information in the field of
endocrine diseases and disorders.
38.
IMPROVEMENT, MAINTENANCE OR REDUCTION OF DECLINE OF MOTOR FUNCTION ASSOCIATED WITH HUNTINGTON DISEASE USING VALBENAZINE
Provided herein are methods for treatment of chorea associated with Huntington disease using a vesicular monoamine transporter isoform 2 (VMAT2) inhibitor. In certain embodiments, the VMAT2 inhibitor is valbenazine or a pharmaceutically acceptable salt thereof.
A61K 31/4745 - QuinoléinesIsoquinoléines condensées en ortho ou en péri avec des systèmes hétérocycliques condensées avec des systèmes cycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. phénanthrolines
A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
A61B 5/11 - Mesure du mouvement du corps entier ou de parties de celui-ci, p. ex. tremblement de la tête ou des mains ou mobilité d'un membre
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
09 - Appareils et instruments scientifiques et électriques
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Downloadable podcasts in the field of health, pharmaceuticals, and medicine; Downloadable podcasts in the field of Huntington’s disease, HD chorea and other medical conditions Production of podcasts; Providing podcasts in the field of health, pharmaceuticals, and medicine; Providing podcasts in the field of Huntington’s disease, HD chorea and other medical conditions
09 - Appareils et instruments scientifiques et électriques
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Downloadable podcasts in the field of health, pharmaceuticals, and medicine; Downloadable podcasts in the field of Huntington’s disease, HD chorea and other medical conditions Production of podcasts; Providing podcasts in the field of health, pharmaceuticals, and medicine; Providing podcasts in the field of Huntington’s disease, HD chorea and other medical conditions
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Promoting awareness of congenital adrenal hyperplasia and
providing a public platform to discuss congenital adrenal
hyperplasia and coping strategies (term considered too vague
by the International Bureau pursuant to Rule 13 (2) (b) of
the Regulations); promoting awareness of adrenal
insufficiency and providing a public platform to discuss
adrenal insufficiency and coping strategies (term considered
too vague by the International Bureau pursuant to Rule 13
(2) (b) of the Regulations); promoting awareness of
endocrine diseases and disorders and providing a public
platform to discuss endocrine diseases and disorders and
coping strategies (term considered too vague by the
International Bureau pursuant to Rule 13 (2) (b) of the
Regulations); promoting the interests of people who have
congenital adrenal hyperplasia and their families and health
care providers by means of public advocacy (term considered
too vague by the International Bureau pursuant to Rule 13
(2) (b) of the Regulations); promoting the interests of
people who have adrenal insufficiency and their families and
health care providers by means of public advocacy (term
considered too vague by the International Bureau pursuant to
Rule 13 (2) (b) of the Regulations); promoting the interests
of people who have endocrine diseases and disorders and
their families and health care providers by means of public
advocacy (term considered too vague by the International
Bureau pursuant to Rule 13 (2) (b) of the Regulations);
maintaining a registry of patients with congenital adrenal
hyperplasia; maintaining a registry of patients with adrenal
insufficiency; maintaining a registry of patients with
endocrine diseases and disorders; updating and maintenance
of information in registries, namely, administering a
patient registry for patients with congenital adrenal
hyperplasia; updating and maintenance of information in
registries, namely, administering a patient registry for
patients with adrenal insufficiency; updating and
maintenance of information in registries, namely,
administering a patient registry for patients with endocrine
diseases and disorders. Providing an in-person health forum for users to participate
in discussions in the field of congenital adrenal
hyperplasia; providing an in-person health forum for users
to participate in discussions in the field of adrenal
insufficiency; providing an in-person health forum for users
to participate in discussions in the field of endocrine
diseases and disorders. Providing information about medical research; providing
medical research information in the field of pharmaceuticals
and congenital adrenal hyperplasia; providing medical
research information in the field of pharmaceuticals and
adrenal insufficiency; providing medical research
information in the field of pharmaceuticals and endocrine
diseases and disorders. Providing medical information; providing medical information
to patients, medical professionals, and insurance companies
in the field of congenital adrenal hyperplasia; providing
medical information to patients, medical professionals, and
insurance companies in the field of adrenal insufficiency;
providing medical information to patients, medical
professionals, and insurance companies in the field of
endocrine diseases and disorders; online information
services, namely, providing medical information in the field
of congenital adrenal hyperplasia; online information
services, namely, providing medical information in the field
of adrenal insufficiency; online information services,
namely, providing medical information in the field of
endocrine diseases and disorders.
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Promoting awareness of congenital adrenal hyperplasia and
providing a public platform to discuss congenital adrenal
hyperplasia and coping strategies (term considered too vague
by the International Bureau pursuant to Rule 13 (2) (b) of
the Regulations); promoting awareness of adrenal
insufficiency and providing a public platform to discuss
adrenal insufficiency and coping strategies (term considered
too vague by the International Bureau pursuant to Rule 13
(2) (b) of the Regulations); promoting awareness of
endocrine diseases and disorders and providing a public
platform to discuss endocrine diseases and disorders and
coping strategies (term considered too vague by the
International Bureau pursuant to Rule 13 (2) (b) of the
Regulations); promoting the interests of people who have
congenital adrenal hyperplasia and their families and health
care providers by means of public advocacy (term considered
too vague by the International Bureau pursuant to Rule 13
(2) (b) of the Regulations); promoting the interests of
people who have adrenal insufficiency and their families and
health care providers by means of public advocacy (term
considered too vague by the International Bureau pursuant to
Rule 13 (2) (b) of the Regulations); promoting the interests
of people who have endocrine diseases and disorders and
their families and health care providers by means of public
advocacy (term considered too vague by the International
Bureau pursuant to Rule 13 (2) (b) of the Regulations);
maintaining a registry of patients with congenital adrenal
hyperplasia; maintaining a registry of patients with adrenal
insufficiency; maintaining a registry of patients with
endocrine diseases and disorders; updating and maintenance
of information in registries, namely, administering a
patient registry for patients with congenital adrenal
hyperplasia; updating and maintenance of information in
registries, namely, administering a patient registry for
patients with adrenal insufficiency; updating and
maintenance of information in registries, namely,
administering a patient registry for patients with endocrine
diseases and disorders. Providing an in-person health forum for users to participate
in discussions in the field of congenital adrenal
hyperplasia; providing an in-person health forum for users
to participate in discussions in the field of adrenal
insufficiency; providing an in-person health forum for users
to participate in discussions in the field of endocrine
diseases and disorders. Providing information about medical research; providing
medical research information in the field of pharmaceuticals
and congenital adrenal hyperplasia; providing medical
research information in the field of pharmaceuticals and
adrenal insufficiency; providing medical research
information in the field of pharmaceuticals and endocrine
diseases and disorders. Providing medical information; providing medical information
to patients, medical professionals, and insurance companies
in the field of congenital adrenal hyperplasia; providing
medical information to patients, medical professionals, and
insurance companies in the field of adrenal insufficiency;
providing medical information to patients, medical
professionals, and insurance companies in the field of
endocrine diseases and disorders; online information
services, namely, providing medical information in the field
of congenital adrenal hyperplasia; online information
services, namely, providing medical information in the field
of adrenal insufficiency; online information services,
namely, providing medical information in the field of
endocrine diseases and disorders.
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical research and development services; Conducting pharmaceutical research for the marketing of pharmaceutical preparations and evaluating epidemiological results; Providing medical research information to others regarding the results of research studies Providing medical information
44.
MUSCARINIC RECEPTOR 4 ANTAGONISTS AND METHODS OF USE
The present invention relates to compounds of Formula (Ia), pharmaceutically acceptable salts of compounds of Formula (Ia), and pharmaceutical compositions thereof that modulate the activity of the muscarinic acetylcholine receptor M4. Compounds, pharmaceutical salts of compounds, and pharmaceutical compositions of the present invention are directed to methods useful in the treatment or prophylaxis of a neurological disease, disorder, or symptom, and conditions related thereto.
C07D 403/14 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant au moins trois hétérocycles
A61K 31/506 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime non condensées et contenant d'autres hétérocycles
A61K 31/519 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
Printed questionnaires in the nature of assessments in the field of healthcare; printed questionnaires in the nature of assessments in the field of tardive dyskinesia
09 - Appareils et instruments scientifiques et électriques
16 - Papier, carton et produits en ces matières
35 - Publicité; Affaires commerciales
41 - Éducation, divertissements, activités sportives et culturelles
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Downloadable electronic publications in the nature of brochures and pamphlets in the field of healthcare and pharmaceuticals Printed publications, namely, brochures and pamphlets in the field of healthcare and pharmaceuticals Promoting the interests of patients by means of public advocacy; promotional sponsorship of patients in the fields of healthcare and pharmaceuticals Educational and entertainment services, namely, providing online interviews featuring patients and healthcare professionals discussing their experiences in the field of healthcare and pharmaceuticals; Providing online non-downloadable electronic publications in the nature of brochures and pamphlets in the field of healthcare and pharmaceuticals Providing medical information; Providing educational information about healthcare via a website; Providing educational information relating to therapeutic properties of pharmaceuticals via a website
09 - Appareils et instruments scientifiques et électriques
16 - Papier, carton et produits en ces matières
35 - Publicité; Affaires commerciales
41 - Éducation, divertissements, activités sportives et culturelles
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Downloadable electronic publications in the nature of brochures and pamphlets in the field of healthcare and pharmaceuticals Printed publications, namely, brochures and pamphlets in the field of healthcare and pharmaceuticals Promoting the interests of patients by means of public advocacy; promotional sponsorship of patients in the fields of healthcare and pharmaceuticals Educational and entertainment services, namely, providing online interviews featuring patients and healthcare professionals discussing their experiences in the field of healthcare and pharmaceuticals; Providing online non-downloadable electronic publications in the nature of brochures and pamphlets in the field of healthcare and pharmaceuticals Providing medical information; Providing educational information about healthcare via a website; Providing educational information relating to therapeutic properties of pharmaceuticals via a website
The present application is related to methods of preparing pharmaceutical compositions comprising a VMAT2 inhibitor and/or identifying therapeutically effective dosages of a VMAT2 inhibitor, wherein the VMAT2 inhibitor is useful for treating neurological and psychiatric diseases and disorders and for achieving an occupancy rate between 80-96% in a subject.
Provided herein are methods for treatment of chorea associated with Huntington's disease using a vesicular monoamine transporter isoform 2 (VMAT2) inhibitor. In certain embodiments, the VMAT2 inhibitor is valbenazine or a pharmaceutically acceptable salt thereof.
A61K 31/4745 - QuinoléinesIsoquinoléines condensées en ortho ou en péri avec des systèmes hétérocycliques condensées avec des systèmes cycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. phénanthrolines
A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
A61P 25/14 - Médicaments pour le traitement des troubles du système nerveux pour traiter les mouvements anormaux, p. ex. chorée, dyskinésie
50.
METHODS FOR THE ADMINISTRATION OF CERTAIN VMAT2 INHIBITORS
Provided herein are methods for treatment of chorea associated with Huntington's disease using a vesicular monoamine transporter isoform 2 (VMAT2) inhibitor. In certain embodiments, the VMAT2 inhibitor is valbenazine or a pharmaceutically acceptable salt thereof.
A61K 31/4745 - QuinoléinesIsoquinoléines condensées en ortho ou en péri avec des systèmes hétérocycliques condensées avec des systèmes cycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. phénanthrolines
A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
A61P 25/14 - Médicaments pour le traitement des troubles du système nerveux pour traiter les mouvements anormaux, p. ex. chorée, dyskinésie
This present disclosure relates to processes for preparing a compound of Formula (A) which is useful as an intermediate in the preparation of mAChR agonist compounds; and compositions comprising the compound of Formula (A).
C12P 17/10 - Préparation de composés hétérocycliques comportant O, N, S, Se ou Te comme uniques hétéro-atomes du cycle l'azote comme unique hétéro-atome du cycle
C12N 9/04 - Oxydoréductases (1.), p. ex. luciférase agissant sur des groupes CHOH comme donneurs, p. ex. oxydase de glucose, déshydrogénase lactique (1.1)
C12P 41/00 - Procédés utilisant des enzymes ou des micro-organismes pour la séparation d'isomères optiques à partir d'un mélange racémique
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical preparations for the treatment of adrenal insufficiency; pharmaceutical preparations for the treatment of hormonal and genetic diseases, disorders and conditions; pharmaceutical preparations for the diagnosis, prevention and treatment of endocrine diseases and disorders; pharmaceutical preparations for the treatment of congenital adrenal hyperplasia; pharmaceuticals for the treatment of rare and orphan hormonal and genetic diseases, disorders and conditions Providing medical research information; providing medical research information in the field of pharmaceuticals and clinical trials focusing on other endocrine diseases and disorders; Scientific research in the nature of conducting clinical trials for pharmaceutical preparations for the treatment of congenital adrenal hyperplasia and other endocrine diseases and disorders, for others; conducting post-authorization pharmaceutical research for the marketing of pharmaceutical preparations and evaluating epidemiological results Providing medical information; providing medical information to patients, medical professionals in the field of other endocrine
diseases and disorders; providing medical information to insurance companies in the field of congenital adrenal hyperplasia and
other endocrine diseases and disorders; on-line information services, namely, providing medical information to patients, medical
professionals in the field of other endocrine diseases and disorders; on-line information services, namely, providing medical
information to insurance companies in the field of congenital adrenal hyperplasia and other endocrine diseases and disorders
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Providing medical research information in the field of pharmaceuticals and clinical trials focusing on congenital adrenal hyperplasia Providing medical information to patients, medical professionals in the field of congenital adrenal hyperplasia; on-line information services, namely, providing medical information to patients, medical professionals in the field of congenital adrenal hyperplasia
SSS)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2-fluoro-5-methyl-N-(thiazol-4-yl)benzenesulfonamide; and uses of said crystalline forms and compositions.
C07D 417/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical preparations for the treatment of adrenal insufficiency; pharmaceutical preparations for the treatment of hormonal and genetic diseases, disorders and conditions; pharmaceutical preparations for the diagnosis, prevention and treatment of endocrine diseases and disorders; pharmaceutical preparations for the treatment of congenital adrenal hyperplasia; pharmaceuticals for the treatment of rare and orphan hormonal and genetic diseases, disorders and conditions Providing medical research information; providing medical research information in the field of pharmaceuticals and clinical trials focusing on congenital adrenal hyperplasia and other endocrine diseases and disorders; Scientific research in the nature of conducting clinical trials for pharmaceutical preparations for the treatment of congenital adrenal hyperplasia and other endocrine diseases and disorders, for others; conducting post-authorization pharmaceutical research for the marketing of pharmaceutical preparations and evaluating epidemiological results Providing medical information; Providing medical information to patients, medical professionals, and insurance companies in the field of congenital adrenal hyperplasia and other endocrine diseases and disorders; on-line information services, namely, providing medical information to patients, medical professionals, and insurance companies in the field of congenital adrenal hyperplasia and other endocrine diseases and disorders
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
pharmaceutical preparations for the treatment of hormonal and genetic diseases, disorders and conditions; pharmaceutical preparations for the treatment of endocrine diseases and disorders; pharmaceutical preparations for the treatment of congenital adrenal hyperplasia; pharmaceuticals for the treatment of rare and orphan hormonal and genetic diseases, disorders and conditions
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Providing medical research information; providing medical research information in the field of pharmaceuticals and clinical trials focusing on congenital adrenal hyperplasia and other endocrine diseases and disorders; Scientific research in the nature of conducting clinical trials for pharmaceutical preparations for the treatment of congenital adrenal hyperplasia and other endocrine diseases and disorders, for others; conducting post-authorization pharmaceutical research for the marketing of pharmaceutical preparations and evaluating epidemiological results Providing medical information; Providing medical information to patients, medical professionals, and insurance companies in the field of congenital adrenal hyperplasia and other endocrine diseases and disorders; on-line information services, namely, providing medical information to patients, medical professionals, and insurance companies in the field of congenital adrenal hyperplasia and other endocrine diseases and disorders
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical preparations for the treatment of adrenal insufficiency; pharmaceutical preparations for the treatment of hormonal and genetic diseases, disorders and conditions; pharmaceutical preparations for the diagnosis, prevention and treatment of endocrine diseases and disorders; pharmaceutical preparations for the treatment of congenital adrenal hyperplasia; pharmaceuticals for the treatment of rare and orphan hormonal and genetic diseases, disorders and conditions Providing medical research information; providing medical research information in the field of pharmaceuticals and clinical trials focusing on congenital adrenal hyperplasia and other endocrine diseases and disorders; Scientific research in the nature of conducting clinical trials for pharmaceutical preparations for the treatment of congenital adrenal hyperplasia and other endocrine diseases and disorders, for others; conducting post-authorization pharmaceutical research for the marketing of pharmaceutical preparations and evaluating epidemiological results Providing medical information; Providing medical information to patients, medical professionals, and insurance companies in the field of congenital adrenal hyperplasia and other endocrine diseases and disorders; on-line information services, namely, providing medical information to patients, medical professionals, and insurance companies in the field of congenital adrenal hyperplasia and other endocrine diseases and disorders
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical preparations for the treatment of adrenal insufficiency; pharmaceutical preparations for the treatment of hormonal and genetic diseases, disorders and conditions; pharmaceutical preparations for the diagnosis, prevention and treatment of endocrine diseases and disorders; pharmaceutical preparations for the treatment of congenital adrenal hyperplasia; pharmaceuticals for the treatment of rare and orphan hormonal and genetic diseases, disorders and conditions Providing medical research information; providing medical research information in the field of pharmaceuticals and clinical trials focusing on congenital adrenal hyperplasia and other endocrine diseases and disorders; Scientific research in the nature of conducting clinical trials for pharmaceutical preparations for the treatment of congenital adrenal hyperplasia and other endocrine diseases and disorders, for others; conducting post-authorization pharmaceutical research for the marketing of pharmaceutical preparations and evaluating epidemiological results Providing medical information; Providing medical information to patients, medical professionals, and insurance companies in the field of congenital adrenal hyperplasia and other endocrine diseases and disorders; on-line information services, namely, providing medical information to patients, medical professionals, and insurance companies in the field of congenital adrenal hyperplasia and other endocrine diseases and disorders
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical preparations for the treatment of adrenal insufficiency; pharmaceutical preparations for the treatment of hormonal and genetic diseases, disorders and conditions; pharmaceutical preparations for the diagnosis, prevention and treatment of endocrine diseases and disorders; pharmaceutical preparations for the treatment of congenital adrenal hyperplasia; pharmaceuticals for the treatment of rare and orphan hormonal and genetic diseases, disorders and conditions Providing medical research information; providing medical research information in the field of pharmaceuticals and clinical trials focusing on congenital adrenal hyperplasia and other endocrine diseases and disorders; Scientific research in the nature of conducting clinical trials for pharmaceutical preparations for the treatment of congenital adrenal hyperplasia and other endocrine diseases and disorders, for others; conducting post-authorization pharmaceutical research for the marketing of pharmaceutical preparations and evaluating epidemiological results Providing medical information; Providing medical information to patients, medical professionals, and insurance companies in the field of congenital adrenal hyperplasia and other endocrine diseases and disorders; on-line information services, namely, providing medical information to patients, medical professionals, and insurance companies in the field of congenital adrenal hyperplasia and other endocrine diseases and disorders
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical research and development services; conducting clinical trials for pharmaceutical preparations; pharmaceutical research services and pharmaceutical product evaluation, namely, conducting post-authorization research for the marketing of pharmaceutical preparations and evaluating epidemiological results; pharmaceutical research and development services in the field of anhedonia, major depressive disorder and mood disorders; conducting clinical trials for others for pharmaceutical preparations for the treatment and prevention of anhedonia, major depressive disorder and mood disorders; pharmaceutical research services and pharmaceutical product evaluation, namely, conducting post-authorization research for the marketing of pharmaceutical preparations for the treatment and prevention of anhedonia, major depressive disorder and mood disorders, and evaluating epidemiological results for treatments for anhedonia, major depressive disorder and mood disorders; providing medical and scientific research information to patients and practitioners in the field of clinical trials, namely, as to the results of clinical trials; providing medical and scientific research information to patients and practitioners in the field of clinical trials, namely, as to the results of clinical trials pertaining to therapies and treatments for anhedonia, major depressive disorder and mood disorders Providing medical information; providing medical information relating to therapies and treatments for anhedonia, major depressive disorder and mood disorders
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical research and development services; conducting clinical trials for pharmaceutical preparations; pharmaceutical research services and pharmaceutical product evaluation, namely, conducting post-authorization research for the marketing of pharmaceutical preparations and evaluating epidemiological results; pharmaceutical research and development services in the field of anhedonia, major depressive disorder and mood disorders; conducting clinical trials for others for pharmaceutical preparations for the treatment and prevention of anhedonia, major depressive disorder and mood disorders; pharmaceutical research services and pharmaceutical product evaluation, namely, conducting post-authorization research for the marketing of pharmaceutical preparations for the treatment and prevention of anhedonia, major depressive disorder and mood disorders, and evaluating epidemiological results for treatments for anhedonia, major depressive disorder and mood disorders; providing medical and scientific research information to patients and practitioners in the field of clinical trials, namely, as to the results of clinical trials; providing medical and scientific research information to patients and practitioners in the field of clinical trials, namely, as to the results of clinical trials pertaining to therapies and treatments for anhedonia, major depressive disorder and mood disorders Providing medical information; providing medical information relating to therapies and treatments for anhedonia, major depressive disorder and mood disorders
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical research and development services; conducting clinical trials for pharmaceutical preparations; pharmaceutical research services and pharmaceutical product evaluation, namely, conducting post-authorization research for the marketing of pharmaceutical preparations and evaluating epidemiological results; pharmaceutical research and development services in the field of anhedonia, major depressive disorder and mood disorders; conducting clinical trials for others for pharmaceutical preparations for the treatment and prevention of anhedonia, major depressive disorder and mood disorders; pharmaceutical research services and pharmaceutical product evaluation, namely, conducting post-authorization research for the marketing of pharmaceutical preparations for the treatment and prevention of anhedonia, major depressive disorder and mood disorders, and evaluating epidemiological results for treatments for anhedonia, major depressive disorder and mood disorders; providing medical and scientific research information to patients and practitioners in the field of clinical trials, namely, as to the results of clinical trials; providing medical and scientific research information to patients and practitioners in the field of clinical trials, namely, as to the results of clinical trials pertaining to therapies and treatments for anhedonia, major depressive disorder and mood disorders Providing medical information; providing medical information relating to therapies and treatments for anhedonia, major depressive disorder and mood disorders
09 - Appareils et instruments scientifiques et électriques
16 - Papier, carton et produits en ces matières
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Administering a patient support program to coordinate access to medicines; administering a patient support program to provide pharmaceutical co-pay assistance; administering a patient support program to provide general education and support and information about available resources for patients, caregivers and healthcare providers; administering a patient support program to provide and assist with insurance coverage and reimbursement information; Promoting awareness of congenital adrenal hyperplasia and providing a public platform to discuss congenital adrenal hyperplasia and coping strategies; Promoting awareness of adrenal insufficiency and providing a public platform to discuss adrenal insufficiency and coping strategies; Promoting awareness of endocrine diseases and disorders and providing a public platform to discuss endocrine diseases and disorders and coping strategies; promoting the interests of people who have congenital adrenal hyperplasia and their families and health care providers by means of public advocacy; promoting the interests of people who have adrenal insufficiency and their families and health care providers by means of public advocacy; promoting the interests of people who have endocrine diseases and disorders and their families and health care providers by means of public advocacy; maintaining a registry of patients with congenital adrenal hyperplasia; maintaining a registry of patients with adrenal insufficiency; maintaining a registry of patients with endocrine diseases and disorders; updating and maintenance of information in registries, namely, administering a patient registry for patients with congenital adrenal hyperplasia; updating and maintenance of information in registries, namely, administering a patient registry for patients with adrenal insufficiency; updating and maintenance of information in registries, namely, administering a patient registry for patients with endocrine diseases and disorders Providing an online forum in the field of health and pharmaceuticals Downloadable children's books; downloadable children's booklets; downloadable children's activity books; downloadable newsletters; downloadable computer software games Printed children's books; printed children's booklets; printed activity books; printed newsletters in the field of endocrine diseases and disorders Educational services; providing mentorship programs in the field of health and pharmaceuticals Providing information about medical research; providing medical research information in the field of pharmaceuticals and congenital adrenal hyperplasia; providing medical research information in the field of pharmaceuticals and adrenal insufficiency; providing medical research information in the field of pharmaceuticals and endocrine diseases and disorders; creating an online community for users for the purpose of participating in discussions in the fields of health, pharmaceuticals, and coping strategies Providing medical information; providing medical information to patients, medical professionals, and insurance companies in the field of congenital adrenal hyperplasia; providing medical information to patients, medical professionals, and insurance companies in the field of adrenal insufficiency; providing medical information to patients, medical professionals, and insurance companies in the field of endocrine diseases and disorders; online information services, namely, providing medical information in the field of congenital adrenal hyperplasia; online information services, namely, providing medical information in the field of adrenal insufficiency; online information services, namely, providing medical information in the field of endocrine diseases and disorders; Providing an in-person health forum for users to participate in discussions in the field of congenital adrenal hyperplasia; Providing an in-person health forum for users to participate in discussions in the field of adrenal insufficiency; Providing an in-person health forum for users to participate in discussions in the field of endocrine diseases and disorders
09 - Appareils et instruments scientifiques et électriques
16 - Papier, carton et produits en ces matières
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Administering a patient support program to coordinate access to medicines; administering a patient support program to provide pharmaceutical co-pay assistance; administering a patient support program to provide general education and support and information about available resources for patients, caregivers and healthcare providers; administering a patient support program to provide and assist with insurance coverage and reimbursement information; Promoting awareness of congenital adrenal hyperplasia and providing a public platform to discuss congenital adrenal hyperplasia and coping strategies; Promoting awareness of adrenal insufficiency and providing a public platform to discuss adrenal insufficiency and coping strategies; Promoting awareness of endocrine diseases and disorders and providing a public platform to discuss endocrine diseases and disorders and coping strategies; promoting the interests of people who have congenital adrenal hyperplasia and their families and health care providers by means of public advocacy; promoting the interests of people who have adrenal insufficiency and their families and health care providers by means of public advocacy; promoting the interests of people who have endocrine diseases and disorders and their families and health care providers by means of public advocacy; maintaining a registry of patients with congenital adrenal hyperplasia; maintaining a registry of patients with adrenal insufficiency; maintaining a registry of patients with endocrine diseases and disorders; updating and maintenance of information in registries, namely, administering a patient registry for patients with congenital adrenal hyperplasia; updating and maintenance of information in registries, namely, administering a patient registry for patients with adrenal insufficiency; updating and maintenance of information in registries, namely, administering a patient registry for patients with endocrine diseases and disorders Providing an online forum in the field of health and pharmaceuticals Downloadable children's books; downloadable children's booklets; downloadable children's activity books; downloadable newsletters; downloadable computer software games Printed children's books; printed children's booklets; printed activity books; printed newsletters in the field of endocrine diseases and disorders Educational services; providing mentorship programs in the field of health and pharmaceuticals Providing information about medical research; providing medical research information in the field of pharmaceuticals and congenital adrenal hyperplasia; providing medical research information in the field of pharmaceuticals and adrenal insufficiency; providing medical research information in the field of pharmaceuticals and endocrine diseases and disorders; creating an online community for users for the purpose of participating in discussions in the fields of health, pharmaceuticals, and coping strategies Providing medical information; providing medical information to patients, medical professionals, and insurance companies in the field of congenital adrenal hyperplasia; providing medical information to patients, medical professionals, and insurance companies in the field of adrenal insufficiency; providing medical information to patients, medical professionals, and insurance companies in the field of endocrine diseases and disorders; online information services, namely, providing medical information in the field of congenital adrenal hyperplasia; online information services, namely, providing medical information in the field of adrenal insufficiency; online information services, namely, providing medical information in the field of endocrine diseases and disorders; Providing an in-person health forum for users to participate in discussions in the field of congenital adrenal hyperplasia; Providing an in-person health forum for users to participate in discussions in the field of adrenal insufficiency; Providing an in-person health forum for users to participate in discussions in the field of endocrine diseases and disorders
66.
DOSAGE REGIME OF CRINECERFONT FOR TREATING CONGENITAL ADRENAL HYPERPLASIA IN A PEDIATRIC SUBJECT
A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone substitués en position 21, p. ex. cortisone, dexaméthasone, prednisone ou aldostérone
A61P 5/38 - Médicaments pour le traitement des troubles du système endocrinien des hormones surrénales
67.
VALBENAZINE FOR USE IN THE ADD-ON TREATMENT OF SCHIZOPHRENIA
Provided herein are methods for the add-on treatment of schizophrenia using a vesicular monoamine transporter isoform 2 (VMAT2) inhibitor. In certain embodiments, the VMAT2 inhibitor is valbenazine or a pharmaceutically acceptable salt thereof.
A61K 31/4745 - QuinoléinesIsoquinoléines condensées en ortho ou en péri avec des systèmes hétérocycliques condensées avec des systèmes cycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. phénanthrolines
A61K 9/48 - Préparations en capsules, p. ex. de gélatine, de chocolat
A61K 31/40 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil
A61K 31/407 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil condensés avec des systèmes hétérocycliques, p. ex. kétorolac, physostigmine
A61K 31/451 - Pipéridines non condensées, p. ex. pipérocaïne ayant un carbocycle lié directement à l'hétérocycle, p. ex. glutéthimide, mépéridine, lopéramide, phencyclidine, piminodine
A61K 31/454 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pimozide, dompéridone
A61K 31/4545 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pipampérone, anabasine
A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p. ex. rifampine, thiothixène ou sparfloxacine
A61K 31/519 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
A61K 31/5415 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec au moins un azote et au moins un soufre comme hétéro-atomes d'un cycle, p. ex. sulthiame condensés en ortho ou en péri avec des systèmes carbocycliques, p. ex. phénothiazine, chlorpromazine, piroxicam
A61K 31/551 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole ayant deux atomes d'azote comme hétéro-atomes d'un cycle, p. ex. clozapine, dilazèpe
A61K 31/553 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole ayant au moins un azote et au moins un oxygène comme hétéro-atomes d'un cycle, p. ex. loxapine, staurosporine
A61K 31/554 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole ayant au moins un azote et au moins un soufre comme hétéro-atomes d'un cycle, p. ex. clothiapine, diltiazem
68.
VALBENAZINE FOR USE IN THE TREATMENT OF DYSKINESIA DUE TO CEREBRAL PALSY
Provided is a method of treating dyskinesia due to cerebral palsy in a patient in need thereof, comprising: administering a vesicular monoamine transporter 2 (VMAT2) inhibitor to the patient in need thereof.
A61K 31/4745 - QuinoléinesIsoquinoléines condensées en ortho ou en péri avec des systèmes hétérocycliques condensées avec des systèmes cycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. phénanthrolines
05 - Produits pharmaceutiques, vétérinaires et hygièniques
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical preparations for human use; pharmaceutical
preparations for the diagnosis, prevention and treatment of
endocrine diseases and disorders; pharmaceutical
preparations for the treatment of congenital adrenal
hyperplasia; pharmaceuticals for human use for the treatment
of rare and orphan diseases, disorders and conditions. Providing medical information; providing medical information
to patients, medical professionals, and insurance companies
in the field of congenital adrenal hyperplasia and other
endocrine diseases and disorders; on-line information
services, namely, providing medical information to patients,
medical professionals, and insurance companies in the field
of congenital adrenal hyperplasia and other endocrine
diseases and disorders.
70.
DOSAGE REGIME OF CRINECERFONT FOR TREATING CONGENITAL ADRENAL HYPERPLASIA
A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone substitués en position 21, p. ex. cortisone, dexaméthasone, prednisone ou aldostérone
A61P 5/38 - Médicaments pour le traitement des troubles du système endocrinien des hormones surrénales
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Providing medical information; providing medical information
to patients, medical professionals, and insurance companies
in the field of congenital adrenal hyperplasia and other
endocrine diseases and disorders; on-line information
services, namely, providing medical information to patients,
medical professionals, and insurance companies in the field
of congenital adrenal hyperplasia and other endocrine
diseases and disorders.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical preparations for human use; pharmaceutical
preparations for the diagnosis, prevention and treatment of
endocrine diseases and disorders; pharmaceutical
preparations for the treatment of congenital adrenal
hyperplasia; pharmaceuticals for human use for the treatment
of rare and orphan diseases, disorders and conditions. Providing medical information to patients, medical
professionals, and insurance companies in the field of
congenital adrenal hyperplasia and other endocrine diseases
and disorders; on-line information services, namely,
providing medical information to patients, medical
professionals, and insurance companies in the field of
congenital adrenal hyperplasia and other endocrine diseases
and disorders.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical preparations for human use; pharmaceutical
preparations for the diagnosis, prevention and treatment of
endocrine diseases and disorders; pharmaceutical
preparations for the treatment of congenital adrenal
hyperplasia; pharmaceuticals for human use for the treatment
of rare and orphan diseases, disorders and conditions. Providing medical information to patients, medical
professionals, and insurance companies in the field of
congenital adrenal hyperplasia and other endocrine diseases
and disorders; on-line information services, namely,
providing medical information to patients, medical
professionals, and insurance companies in the field of
congenital adrenal hyperplasia and other endocrine diseases
and disorders.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Pharmaceutical preparations for human use; pharmaceutical
preparations for the diagnosis, prevention and treatment of
endocrine diseases and disorders; pharmaceutical
preparations for the treatment of congenital adrenal
hyperplasia; pharmaceuticals for human use for the treatment
of rare and orphan diseases, disorders and conditions.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical preparations for human use; pharmaceutical
preparations for the diagnosis, prevention and treatment of
endocrine diseases and disorders; pharmaceutical
preparations for the treatment of congenital adrenal
hyperplasia; pharmaceuticals for human use for the treatment
of rare and orphan diseases, disorders and conditions. Providing medical information to patients, medical
professionals, and insurance companies in the field of
congenital adrenal hyperplasia and other endocrine diseases
and disorders; on-line information services, namely,
providing medical information to patients, medical
professionals, and insurance companies in the field of
congenital adrenal hyperplasia and other endocrine diseases
and disorders.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Pharmaceutical preparations for human use; pharmaceutical
preparations for the diagnosis, prevention and treatment of
endocrine diseases and disorders; pharmaceutical
preparations for the treatment of congenital adrenal
hyperplasia; pharmaceuticals for human use for the treatment
of rare and orphan diseases, disorders and conditions.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Pharmaceutical preparations for human use; pharmaceutical
preparations for the diagnosis, prevention and treatment of
endocrine diseases and disorders; pharmaceutical
preparations for the treatment of congenital adrenal
hyperplasia; pharmaceuticals for human use for the treatment
of rare and orphan diseases, disorders and conditions.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical preparations for human use; pharmaceutical
preparations for the diagnosis, prevention and treatment of
endocrine diseases and disorders; pharmaceutical
preparations for the treatment of congenital adrenal
hyperplasia; pharmaceuticals for human use for the treatment
of rare and orphan diseases, disorders and conditions. Providing medical information; providing medical information
to patients, medical professionals, and insurance companies
in the field of congenital adrenal hyperplasia and other
endocrine diseases and disorders; on-line information
services, namely, providing medical information to patients,
medical professionals, and insurance companies in the field
of congenital adrenal hyperplasia and other endocrine
diseases and disorders.
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
(1) Providing medical information; providing medical information to patients, medical professionals, and insurance companies in the field of congenital adrenal hyperplasia and other endocrine diseases and disorders; on-line information services, namely, providing medical information to patients, medical professionals, and insurance companies in the field of congenital adrenal hyperplasia and other endocrine diseases and disorders.
The present disclosure provides deuterated compounds and their use as agonists of the M4 muscarinic acetylcholine receptor in the treatment or prevention of various diseases or disorders associated with the M4 receptor.
C07D 401/14 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant au moins trois hétérocycles
C07B 59/00 - Introduction d'isotopes d'éléments dans les composés organiques
A61P 25/18 - Antipsychotiques, c.-à-d. neuroleptiquesMédicaments pour le traitement de la manie ou de la schizophrénie
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
81.
Synthetic methods for preparation of 4-(2-chloro-4-methoxy-5-methylphenyl)-n-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-n-prop-2-ynyl-1,3-thiazol-2-amine
The present disclosure relates to the fields of chemistry and medicine, more particularly to processes for making 4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-prop-2-ynyl-1,3-thi-azol-2-amine (Compound 1), pharmaceutically acceptable salts, and crystalline forms thereof, for the treatment of congenital adrenal hyperplasia (CAH).
A61K 9/28 - DragéesPilules ou comprimés avec revêtements
A61K 9/48 - Préparations en capsules, p. ex. de gélatine, de chocolat
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
A61K 47/14 - Esters d’acides carboxyliques, p. ex. acides gras monoglycérides, triglycérides à chaine moyenne, parabènes ou esters d’acide gras de PEG
A61K 47/22 - Composés hétérocycliques, p. ex. acide ascorbique, tocophérol ou pyrrolidones
A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
A61K 47/32 - Composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. carbomères
C07D 277/42 - Radicaux amino ou imino substitués par des radicaux hydrocarbonés ou par des radicaux hydrocarbonés substitués
The present application relates to processes for preparing (S)-(2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-yl 2-amino-3-methylbutanoate di(4-methylbenzenesulfonate), which is an inhibitor of vesicular monoamine transporter 2 (VMAT2) useful in the treatment of hyperkinetic movement disorders such as tardive dyskinesia (TD).
A61K 31/4375 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à six chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. quinolizines, naphtyridines, berbérine, vincamine
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Pharmaceutical preparations for human use; pharmaceutical preparations for the prevention and treatment of hormonal, genetic, and endocrine diseases, disorders, and conditions; pharmaceutical preparations for human use for the treatment of rare and orphan diseases, disorders, and conditions; pharmaceutical preparations for the treatment of congenital adrenal hyperplasia.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
(1) Pharmaceutical preparations for human use; pharmaceutical preparations for the diagnosis, prevention and treatment of endocrine diseases and disorders; pharmaceutical preparations for the treatment of congenital adrenal hyperplasia; pharmaceuticals for human use for the treatment of rare and orphan diseases, disorders and conditions. (1) Providing medical information to patients, medical professionals, and insurance companies in the field of congenital adrenal hyperplasia and other endocrine diseases and disorders; on-line information services, namely, providing medical information to patients, medical professionals, and insurance companies in the field of congenital adrenal hyperplasia and other endocrine diseases and disorders.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
(1) Pharmaceutical preparations for human use; pharmaceutical preparations for the diagnosis, prevention and treatment of endocrine diseases and disorders; pharmaceutical preparations for the treatment of congenital adrenal hyperplasia; pharmaceuticals for human use for the treatment of rare and orphan diseases, disorders and conditions. (1) Providing medical information to patients, medical professionals, and insurance companies in the field of congenital adrenal hyperplasia and other endocrine diseases and disorders; on-line information services, namely, providing medical information to patients, medical professionals, and insurance companies in the field of congenital adrenal hyperplasia and other endocrine diseases and disorders.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
(1) Pharmaceutical preparations for human use; pharmaceutical preparations for the diagnosis, prevention and treatment of endocrine diseases and disorders; pharmaceutical preparations for the treatment of congenital adrenal hyperplasia; pharmaceuticals for human use for the treatment of rare and orphan diseases, disorders and conditions. (1) Providing medical information to patients, medical professionals, and insurance companies in the field of congenital adrenal hyperplasia and other endocrine diseases and disorders; on-line information services, namely, providing medical information to patients, medical professionals, and insurance companies in the field of congenital adrenal hyperplasia and other endocrine diseases and disorders.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
pharmaceutical preparations for the prevention and treatment of hormonal, genetic, and endocrine diseases, disorders, and conditions; pharmaceutical preparations for human use for the treatment of rare and orphan hormonal and genetic diseases, disorders, and conditions; pharmaceutical preparations for the treatment of congenital adrenal hyperplasia
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Promoting the interests of people who have congenital adrenal hyperplasia and their families and health care providers by means of public advocacy; maintaining a registry of patients with congenital adrenal hyperplasia; Updating and maintenance of information in registries, namely, administering a patient registry for patients with congenital adrenal hyperplasia Medical and scientific research services; providing an online computer database that contains data on clinical outcomes, patient-reported outcomes, clinician-reported outcomes, and health care resource utilization for medical and scientific research purposes; providing information in the field of medical and scientific research featuring a registry of patients with congenital adrenal hyperplasia; administering a scientific advisory committee in the nature of providing scientific advice and scientific consultation relating to congenital adrenal hyperplasia Providing medical information; providing a website featuring a registry of patients with congenital adrenal hyperplasia for medical treatment purposes; providing medical and health information to consumers, patients, doctors, and caregivers in the field of congenital adrenal hyperplasia
The present disclosure relates to compounds of Formula (I) that modulate the activity of G-protein coupled receptor 52 (GPR52), pharmaceutically acceptable salts of compounds of Formula (I), and pharmaceutical compositions thereof. Compounds, pharmaceutical salts of compounds, and pharmaceutical compositions of the present disclosure are directed to methods useful in the treatment or prophylaxis of a neurological disease or disorder and conditions related thereto.
The present disclosure relates to compounds of Formula (I) that modulate the activity of G-protein coupled receptor 52 (GPR52), pharmaceutically acceptable salts of compounds of Formula (I), and pharmaceutical compositions thereof. Compounds, pharmaceutical salts of compounds, and pharmaceutical compositions of the present disclosure are directed to methods useful in the treatment or prophylaxis of a neurological disease or disorder and conditions related thereto.
A61K 31/4418 - Pyridines non condenséesLeurs dérivés hydrogénés ayant un carbocycle lié directement à l'hétérocycle, p. ex. cyproheptadine
A61K 31/4545 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pipampérone, anabasine
A61K 31/4725 - Isoquinoléines non condensées, p. ex. papavérine contenant d'autres hétérocycles
C07D 401/04 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
90.
METHODS FOR THE COMBINED ADMINISTRATION OF DEUTETRABENAZINE AND A CYP2D6 INHIBITOR
Provided is a method of treating a neurological or psychiatric disease or disorder in a patient in need thereof, comprising: administering a vesicular monoamine transporter 2 (VMAT2) inhibitor to the patient in need thereof, the patient also being administered a strong cytochrome P450 2D6 (CYP2D6) inhibitor.
A61K 31/4738 - QuinoléinesIsoquinoléines condensées en ortho ou en péri avec des systèmes hétérocycliques
A61K 31/137 - Arylalkylamines, p. ex. amphétamine, épinéphrine, salbutamol, éphédrine
A61K 31/138 - Aryloxyalkylamines, p. ex. propranolol, tamoxifène, phénoxybenzamine
A61K 31/4525 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'oxygène comme hétéro-atome du cycle
A61K 31/49 - Dérivés du cinchonane, p. ex. quinine
91.
METHODS FOR THE ADMINISTRATION OF CERTAIN VMAT2 INHIBITORS
Provided is a method of treating a neurological or psychiatric disease or disorder in a patient in need thereof, comprising: administering a vesicular monoamine transporter 2 (VMAT2) inhibitor to the patient in need thereof wherein the patient is a CYP2D6 poor metabolizer.
A61K 31/4745 - QuinoléinesIsoquinoléines condensées en ortho ou en péri avec des systèmes hétérocycliques condensées avec des systèmes cycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. phénanthrolines
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Pharmaceutical preparations for human use; pharmaceutical
preparations for the prevention and treatment of hormonal,
genetic, and endocrine diseases, disorders, and conditions;
pharmaceutical preparations for human use for the treatment
of rare and orphan diseases, disorders, and conditions;
pharmaceutical preparations for the treatment of congenital
adrenal hyperplasia.
The present disclosure relates to compounds of Formula (I) capable of modulating the activity of GPR52. The present disclosure further provides a process for the preparation of compounds of Formula (1) and methods of using compounds of Formula (I) in the management of diseases or disorders associated with the activity of GPR52 including, but not limited to, the treatment of various neurological conditions.
A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 401/14 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant au moins trois hétérocycles
C07D 403/12 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 405/14 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant au moins trois hétérocycles
A61K 31/416 - 1,2-Diazoles condensés avec des systèmes carbocycliques, p. ex. indazole
A61K 31/437 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à cinq chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. indolizine, bêta-carboline
A61K 31/439 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle le cycle formant une partie d'un système cyclique ponté, p. ex. quinuclidine
A61K 31/4439 - Pyridines non condenséesLeurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p. ex. oméprazole
A61K 31/444 - Pyridines non condenséesLeurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p. ex. amrinone
A61K 31/454 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pimozide, dompéridone
A61K 31/4545 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pipampérone, anabasine
The present disclosure relates to compounds of formula (I), which are capable of modulating the activity of GPR52. The present disclosure further provides a process for the preparation of said compounds and methods of using said compounds in the management of diseases or disorders associated with the activity of GPR52 including, but not limited to, the treatment of various neurological conditions. (Formula (I))
C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 405/12 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
A61K 31/4418 - Pyridines non condenséesLeurs dérivés hydrogénés ayant un carbocycle lié directement à l'hétérocycle, p. ex. cyproheptadine
A61K 31/444 - Pyridines non condenséesLeurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p. ex. amrinone
A61K 31/4545 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pipampérone, anabasine
The present disclosure relates to compounds of Formula (I) capable of modulating the activity of GPR52. The present disclosure further provides a process for the preparation of compounds of Formula (1) and methods of using compounds of Formula (I) in the management of diseases or disorders associated with the activity of GPR52 including, but not limited to, the treatment of various neurological conditions.
C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 405/12 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 413/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 417/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 491/052 - Systèmes condensés en ortho avec un seul atome d'oxygène comme hétéro-atome du cycle contenant de l'oxygène le cycle contenant de l'oxygène étant à six chaînons
A61K 31/444 - Pyridines non condenséesLeurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p. ex. amrinone
A61K 31/4439 - Pyridines non condenséesLeurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p. ex. oméprazole
A61K 31/437 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à cinq chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. indolizine, bêta-carboline
A61K 31/443 - Pyridines non condenséesLeurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'oxygène comme hétéro-atome du cycle
A61K 31/538 - 1,4-Oxazines, p. ex. morpholine condensées en ortho ou en péri avec des systèmes carbocycliques
A61K 31/4709 - Quinoléines non condensées contenant d'autres hétérocycles
A61K 31/4725 - Isoquinoléines non condensées, p. ex. papavérine contenant d'autres hétérocycles
A61K 31/4436 - Pyridines non condenséesLeurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un hétérocycle avec le soufre comme hétéro-atome du cycle
A61K 31/517 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des systèmes carbocycliques, p. ex. quinazoline, périmidine
A61K 31/498 - Pyrazines ou pipérazines condensées en ortho ou en péri avec des systèmes carbocycliques, p. ex. quinoxaline, phénazine
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical research and development services; conducting clinical trials for others for pharmaceutical preparations; pharmaceutical research services and pharmaceutical product evaluation, namely, conducting post-authorization research for the marketing of pharmaceutical preparations and evaluating epidemiological results; pharmaceutical research and development services in the field of major depressive disorder and neurological, central nervous system, psychiatric, and mood disorders; conducting clinical trials for others for pharmaceutical preparations for the treatment and prevention of major depressive disorder and neurological, central nervous system, psychiatric, and mood disorders; pharmaceutical research services and pharmaceutical product evaluation, namely, conducting post-authorization research for the marketing of pharmaceutical preparations for the treatment and prevention of major depressive disorder and neurological, central nervous system, psychiatric, and mood disorders, and evaluating epidemiological results for treatments for major depressive disorder and neurological, central nervous system, psychiatric, and mood disorders; providing medical and scientific research information to patients and practitioners in the field of clinical trials, namely, as to the results of clinical trials; providing medical and scientific research information to patients and practitioners in the field of clinical trials, namely, as to the results of clinical trials pertaining to therapies and treatments for major depressive disorder and neurological, central nervous system, psychiatric, and mood disorders. Providing medical information; providing medical information relating to therapies and treatments for major depressive disorder and neurological, central nervous system, psychiatric, and mood disorders.
97.
HEXAHYDRO-2H-PYRIDO[2,1-A]ISOQUINOLINE VMAT2 INHIBITORS AND METHODS OF USE
This disclosure relates to, inter alia, certain compounds, compositions, and pharmaceutical compositions thereof, that modulate the activity of the transporter protein vesicular monoamine transporter-2 (VMAT2) and are directed to methods useful in the treatment of transporter protein vesicular monoamine transporter-2 mediated disorders, such as, neurological or psychiatric disease or disorders, including but not limited to, hyperkinetic movement disorders (e.g., tardive dyskinesia, Tourette's syndrome, Huntington's disease, tics, ataxia, chorea (such as, chorea associated with Huntington's disease), dystonia, hemifacial spasm, myoclonus, restless leg syndrome, and tremors). The disclosure further relates to synthetic methods and intermediates useful in the preparation of the compounds.
A61K 31/4375 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à six chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. quinolizines, naphtyridines, berbérine, vincamine
A61P 25/26 - Psychostimulants, p. ex. nicotine, cocaïne
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Promoting awareness of tardive dyskinesia; Promoting the interests of people who have tardive dyskinesia and their families and health care providers by means of public advocacy Providing healthcare information for patients and caregivers in the field of tardive dyskinesia; Providing healthcare information for healthcare providers in the field of tardive dyskinesia; Providing medical information; Providing medical information for patients and caregivers in the field of tardive dyskinesia; Providing medical information for healthcare providers in the field of tardive dyskinesia; Online information services, namely, providing medical information in the field of tardive dyskinesia
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Promoting awareness of Huntington's disease and chorea associated with Huntington's disease; Promoting the interests of people who have Huntington's disease and chorea associated with Huntington's disease and their families and health care providers by means of public advocacy Providing healthcare information for patients and caregivers in the field of Huntington's disease and chorea associated with Huntington's disease; Providing medical information; providing medical information for patients and caregivers in the field of Huntington's disease and chorea associated with Huntington's disease; Online information services, namely, providing medical information in the field of Huntington's disease and chorea associated with Huntington's disease
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Promoting awareness of congenital adrenal hyperplasia and promoting awareness of congenital adrenal hyperplasia by providing a public in-person platform to discuss congenital adrenal hyperplasia and coping strategies; Promoting awareness of adrenal insufficiency and promoting awareness of adrenal insufficiency by providing a public in-person platform to discuss adrenal insufficiency and coping strategies; Promoting awareness of endocrine diseases and disorders and promoting awareness of endocrine diseases and disorders by providing a public in-person platform to discuss endocrine diseases and disorders and coping strategies; promoting the interests of people who have congenital adrenal hyperplasia and their families and health care providers by means of public advocacy; promoting the interests of people who have adrenal insufficiency and their families and health care providers by means of public advocacy; promoting the interests of people who have endocrine diseases and disorders and their families and health care providers by means of public advocacy; maintaining a registry of patients with congenital adrenal hyperplasia; maintaining a registry of patients with adrenal insufficiency; maintaining a registry of patients with endocrine diseases and disorders; updating and maintenance of information in registries, namely, administering a patient registry for patients with congenital adrenal hyperplasia; updating and maintenance of information in registries, namely, administering a patient registry for patients with adrenal insufficiency; updating and maintenance of information in registries, namely, administering a patient registry for patients with endocrine diseases and disorders Promoting awareness of congenital adrenal hyperplasia by providing a public online platform in the nature of an online forum to discuss congenital adrenal hyperplasia and coping strategies; Promoting awareness of adrenal insufficiency by providing a public online platform in the nature of an online forum to discuss adrenal insufficiency and coping strategies; Promoting awareness of endocrine diseases and disorders by providing a public online platform in the nature of an online forum to discuss endocrine diseases and disorders and coping strategies Providing information about medical research; providing medical research information in the field of pharmaceuticals and congenital adrenal hyperplasia; providing medical research information in the field of pharmaceuticals and adrenal insufficiency; providing medical research information in the field of pharmaceuticals and endocrine diseases and disorders Providing medical information; providing medical information to patients, medical professionals, and insurance companies in the field of congenital adrenal hyperplasia; providing medical information to patients, medical professionals, and insurance companies in the field of adrenal insufficiency; providing medical information to patients, medical professionals, and insurance companies in the field of endocrine diseases and disorders; online information services, namely, providing medical information in the field of congenital adrenal hyperplasia; online information services, namely, providing medical information in the field of adrenal insufficiency; online information services, namely, providing medical information in the field of endocrine diseases and disorders; Providing medical information in the nature of providing an in-person health forum for users to participate in discussions in the field of congenital adrenal hyperplasia; Providing medical information in the nature of providing an in-person health forum for users to participate in discussions in the field of adrenal insufficiency; Providing medical information in the nature of providing an in-person health forum for users to participate in discussions in the field of endocrine diseases and disorders
