The present invention generally relates to the field of blood treatment. More particularly, the invention relates to an ex vivo method for treating an immunological dysfunction of blood. The invention also relates to an ex vivo method for removing toxic or inflammatory compounds from blood plasma and/or supplementing blood plasma with immunologically active compounds. The methods of the invention comprise the steps of extracorporeally separating at least part of the plasma from the blood and conducting the separated plasma through a plasma-permeable hollow fiber filter with immune cells located thereon such that the plasma comes into contact with the immune cells. The invention also relates to the use of a plasma-permeable hollow fiber filter with immune cells located thereon for the ex vivo treatment of an immunological dysfunction of blood. Finally, the present invention relates to the use of a plasma-permeable hollow fiber filter with immune cells located thereon for removing toxic or inflammatory compounds from blood plasma and/or supplementing blood plasma with immunologically active compounds.
ex vivoex vivo ex vivo ex vivo treatment of an immunological dysfunction of blood. Finally, the present invention relates to the use of a plasma-permeable hollow fiber filter with immune cells located thereon for removing toxic or inflammatory compounds from blood plasma and/or supplementing blood plasma with immunologically active compounds.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Biological and biochemical preparations, in particular in
form of antibodies, antibody derivatives, binding proteins
and peptides for laboratory and experimentation purposes, in
particular for conducting experimental assays (other than
for medical or veterinary purposes). Pharmaceutical and veterinary preparations; biological and
biochemical preparations in form of antibodies, antibody
derivatives, binding proteins and peptides for medical or
veterinary purposes; biological and biochemical preparations
in form of bifunctional or multifunctional proteins with
binding affinity to immune cells, in particular with binding
affinity to T cells and natural killer (NK) cells, in
particular for the subsequent targeting of cancer cells;
biological and biochemical preparations for diagnostic and
therapeutic use, in particular in form of antibodies,
antibody derivatives, binding proteins and peptides;
biological and biochemical preparations in form of
antibodies, antibody derivatives, binding proteins and
peptides for use within the framework of experimental and
medical or veterinary assays; none of the aforesaid goods in
this class for use relating to kidney injury and all of the
aforesaid goods in this class other than cardiovascular
products. Surgical, medical, dental and veterinary apparatus and
instruments for the treatment of infections, in particular
for the treatment of sepsis; artificial limbs, eyes and
teeth; orthopedic articles; suture materials; therapeutic
and assistive devices adapted for persons with disabilities;
massage apparatus; apparatus, devices and articles for
nursing infants; sexual activity apparatus, devices and
articles; none of the aforesaid goods in this class for use
relating to aneurysms, embolisation procedures or kidney
injury. Scientific and technological services, research and design
in the field of immunotherapy, in particular in the field of
immuno-oncology; scientific and technological services,
research and design in the field of virology; scientific and
technological services, research and design in the field of
antiinfectives; scientific and technological services,
research and design in the field of neurodegenerative
diseases; scientific and technological services, research
and design in the filed of autoimmune diseases; in
particular all of the aforesaid services related to the use
of antibodies, antibody derivatives, binding proteins and
peptides; scientific and technological services, research
and design in the field of immunotherapy by means of
activating or modulating innate and adaptive immunity, in
particular in the field of immune-oncology; industrial
analysis and research services. Medical services, in particular in the field of
immunotherapy, in particular in the field of immuno-oncology
or relating to severe infections or sepsis; medical services
in the field of virology; medical services in the field of
antiinfectives; medical services in the field of
neurodegenerative diseases; medical services in the field of
autoimmune diseases; in particular all of the aforesaid
services related to the use of antibodies, antibody
derivatives, binding proteins and peptides; medical services
in the field of immunotherapy by means of activating or
modulating innate and adaptive immunity, in particular in
the field of immuno-oncology; none of the aforesaid services
in this class being medical services relating to the
treatment of aneurysms and all of the aforesaid services in
this class other than cardiovascular products.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
(1) Biological and biochemical preparations, in particular in form of antibodies, antibody derivatives, binding proteins and peptides for laboratory and experimentation purposes, in particular for conducting experimental assays (other than for medical or veterinary purposes) for detecting immune disorders, sepsis and infections
(2) Pharmaceutical and veterinary preparations, namely in form of antibodies, antibody derivatives, binding proteins, cytokines, chemokines, growth factors and peptides as well as immune cells, in particular B lymphocytes, T lymphocytes, phagocytes, dendritic cells and natural killer (NK) cells for medical or veterinary purposes in particular for detecting and treatment of immune disorders, sepsis and infections; biological and biochemical preparations in form of antibodies, antibody derivatives, binding proteins and peptides for medical or veterinary purposes in particular for detecting and treatment of immune disorders, sepsis and infections; biological and biochemical preparations in form of bifunctional or multifunctional proteins with binding affinity to immune cells, in particular with binding affinity to T cells and natural killer (NK) cells, in particular for the subsequent targeting of cancer cells; biological and biochemical preparations for diagnostic and therapeutic use, in particular in form of antibodies, antibody derivatives, binding proteins and peptides for detecting and treatment of immune disorders, sepsis and infections; biological and biochemical preparations in form of antibodies, antibody derivatives, binding proteins and peptides for use within the framework of experimental and medical or veterinary assays for detecting and treatment of immune disorders, sepsis and infections; none of the aforesaid goods for use relating to kidney injury and all of the aforesaid goods other than cardiovascular products.
(3) Surgical, medical, dental and veterinary apparatus and instruments for the treatment of infections, in particular for the treatment of sepsis; artificial limbs, eyes and teeth; suture materials; therapeutic and assistive devices adapted for persons with disabilities, namely, extracorporeal apheresis machines; apparatus, devices and articles for nursing infants, namely, blood transfusion apparatus, infusion pumps, medical tubing for transfusions, blood administration sets comprised of infusion pumps, medical tubing for administering fluids to patients, stopcocks for infusion of fluids and blood filters, extension sets comprised of stopcocks for infusion of fluids, infusion manifolds and infusion valves for medical purposes; none of the aforesaid goods for use relating to aneurysms, embolisation procedures or kidney injury. (1) Scientific and technological services, research and design in the field of immunotherapy, in particular in the field of immuno-oncology; scientific and technological services, research and design in the field of virology; scientific and technological services, research and design in the field of antiinfectives; scientific and technological services, research and design in the field of neurodegenerative diseases; scientific and technological services, research and design in the field of autoimmune diseases; in particular all of the aforesaid services related to the use of antibodies, antibody derivatives, binding proteins and peptides; scientific and technological services, research and design in the field of immunotherapy by means of activating or modulating innate and adaptive immunity, in particular in the field of immune-oncology.
(2) Medical services, in particular in the field of immunotherapy, in particular in the field of immuno-oncology or relating to severe infections or sepsis; medical services in the field of virology; medical services in the field of antiinfectives; medical services in the field of neurodegenerative diseases; medical services in the field of autoimmune diseases; in particular all of the aforesaid services related to the use of antibodies, antibody derivatives, binding proteins and peptides; medical services in the field of immunotherapy by means of activating or modulating innate and adaptive immunity, in particular in the field of immuno-oncology; none of the aforesaid services being medical services relating to the treatment of aneurysms and all of the aforesaid services other than cardiovascular products.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Biological and biochemical preparations, in particular in form of antibodies, antibody derivatives, binding proteins and peptides for laboratory and experimentation purposes, in particular for conducting experimental assays, other than for therapeutic medical or veterinary purposes Biological and biochemical preparations in form of antibodies, antibody derivatives, binding proteins and peptides for medical or veterinary diagnostic purposes; biological and biochemical preparations in form of bifunctional or multifunctional proteins with binding affinity to immune cells, in particular with binding affinity to T cells and natural killer (NK) cells, in particular for the subsequent targeting of cancer cells; biological and biochemical preparations for diagnostic and therapeutic use, in particular in form of antibodies, antibody derivatives, binding proteins and peptides; biological and biochemical preparations in form of antibodies, antibody derivatives, binding proteins and peptides for use within the framework of experimental and medical or veterinary assays; none of the aforesaid goods in this class for use relating to kidney injury and all of the aforesaid goods in this class other than cardiovascular products Surgical, medical, dental and veterinary apparatus and instruments for extracorporeal blood and plasma treatments or apheresis devices as well as infusion or transfusion devices for the treatment of infections, in particular for the treatment of sepsis; artificial limbs, eyes and teeth; suture materials; therapeutic and assistive devices adapted for persons with disabilities, namely, extracorporeal apheresis devices; massage apparatus; apparatus, devices and articles for nursing infants, namely, infusion and transfusion devices; none of the aforesaid goods in this class for use relating to aneurysms, embolisation procedures or kidney injury Scientific and technological services, namely, scientific research and design in the field of immunotherapy, in particular in the field of immuno-oncology; scientific and technological services, namely, scientific research and design in the field of virology; scientific and technological services, namely, scientific research and design in the field of antiinfectives; scientific and technological services, namely, scientific research and design in the field of neurodegenerative diseases; scientific and technological services, namely, scientific research and design in the field of autoimmune diseases; in particular all of the aforesaid services related to the use of antibodies, antibody derivatives, binding proteins and peptides; scientific and technological services, namely, scientific research and design in the field of immunotherapy by means of activating or modulating innate and adaptive immunity, in particular in the field of immune-oncology Medical services, in particular in the field of immunotherapy, in particular in the field of immuno-oncology or relating to severe infections or sepsis; medical services in the field of virology; medical services in the field of antiinfectives; medical services in the field of neurodegenerative diseases; medical services in the field of autoimmune diseases; in particular all of the aforesaid services related to the use of antibodies, antibody derivatives, binding proteins and peptides; medical services in the field of immunotherapy by means of activating or modulating innate and adaptive immunity, in particular in the field of immuno-oncology; none of the aforesaid services in this class being medical services relating to the treatment of aneurysms and all of the aforesaid services in this class other than cardiovascular products
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Biological and biochemical preparations, in particular in form of antibodies, antibody derivatives, binding proteins and peptides for laboratory and experimentation purposes, in particular for conducting experimental assays (other than for medical or veterinary purposes). Pharmaceutical and veterinary preparations; biological and biochemical preparations in form of antibodies, antibody derivatives, binding proteins and peptides for medical or veterinary purposes; biological and biochemical preparations in form of bifunctional or multifunctional proteins with binding affinity to immune cells, in particular with binding affinity to T cells and natural killer (NK) cells, in particular for the subsequent targeting of cancer cells; biological and biochemical preparations for diagnostic and therapeutic use, in particular in form of antibodies, antibody derivatives, binding proteins and peptides; biological and biochemical preparations in form of antibodies, antibody derivatives, binding proteins and peptides for use within the framework of experimental and medical or veterinary assays; None of the aforesaid goods in class 5 for use relating to kidney injury and all of the aforesaid goods in class 5 other than cardiovascular products. Surgical, medical, dental and veterinary apparatus and instruments for the treatment of infections, in particular for the treatment of sepsis; Artificial limbs, eyes and teeth; Orthopedic articles; Suture materials; Therapeutic and assistive devices adapted for persons with disabilities; Massage apparatus; Apparatus, devices and articles for nursing infants; Sexual activity apparatus, devices and articles; None of the aforesaid goods in class 10 for use relating to aneurysms, embolisation procedures or kidney injury. Scientific and technological services, research and design in the field of immunotherapy, in particular in the field of immuno-oncology; scientific and technological services, research and design in the field of virology; scientific and technological services, research and design in the field of antiinfectives; scientific and technological services, research and design in the field of neurodegenerative diseases; scientific and technological services, research and design in the filed of autoimmune diseases; in particular all of the aforesaid services related to the use of antibodies, antibody derivatives, binding proteins and peptides; scientific and technological services, research and design in the field of immunotherapy by means of activating or modulating innate and adaptive immunity, in particular in the field of immune-oncology; Industrial analysis and research services. Medical services, in particular in the field of immunotherapy, in particular in the field of immuno-oncology or Relating to severe infections or sepsis; medical services in the field of virology; medical services in the field of antiinfectives; medical services in the field of neurodegenerative diseases; medical services in the field of autoimmune diseases; in particular all of the aforesaid services related to the use of antibodies, antibody derivatives, binding proteins and peptides; medical services in the field of immunotherapy by means of activating or modulating innate and adaptive immunity, in particular in the field of immuno-oncology; None of the aforesaid services in class 44 being medical services relating to the treatment of aneurysms and all of the aforesaid services in class 44 other than cardiovascular products.
7.
Method for preparing a leukocyte preparation and leukocyte preparation
A method for preparing a leukocyte preparation from a leukocyte fraction and a correspondingly prepared or obtainable leukocyte preparation and its use. The methods include: a) sedimenting the leukocyte fraction removing leukocyte supernatant from the sediment, wherein the leukocyte supernatant is collected or remains in a leukocyte container, b) sedimenting the leukocytes in the leukocyte container, c) washing the sediment in the leukocyte container with a saline solution, and d) resuspending the sediment in the leukocyte container in a storage solution.
Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. (Allemagne)
Inventeur(s)
Altrichter, Jens
Mitzner, Steffen
Lübcke, Antje
Selleng, Kathleen
Doss, Fanny
Koch, Stephanie
Abrégé
A method for preparing a leukocyte preparation from a leukocyte fraction and a correspondingly prepared or obtainable leukocyte preparation and its use. The method includes: a) sedimenting the leukocyte fraction removing leukocyte supernatant from the sediment, wherein the leukocyte supernatant is collected or remains in a leukocyte container, b) sedimenting the leukocytes in the leukocyte container, c) washing the sediment in the leukocyte container with a saline solution, and d) resuspending the sediment in the leukocyte container in a storage solution.
FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V. (Allemagne)
Inventeur(s)
Altrichter, Jens
Mitzner, Steffen
Lübcke, Antje
Selleng, Kathleen
Doss, Fanny
Koch, Stephanie
Abrégé
The invention relates to a method for producing a leukocyte preparation from a leukocyte fraction. The invention further relates to a correspondingly produced or producible leukocyte preparation, and to the use thereof. The method according to the invention comprises the following method steps: a) sedimentation of the leukocyte fraction until a dividing line has formed between the sedimented erythrocytes and a leukocyte supernatant, separation of the leukocyte supernatant from the sediment, wherein the leukocyte supernatant is collected in, or remains in, a leukocyte container, b) sedimentation of the leukocytes in the leukocyte container, wherein a supernatant forms that is low in leukocytes, and removal of the supernatant low in leukocytes from the leukocyte container, c) washing of the sediment in the leukocyte container with a saline solution, wherein the sedimented cells are resuspended in the saline solution, the solution is sedimented and a resulting supernatant is removed, and d) resuspension of the sediment in the leukocyte container in a storage solution.
H04M 9/02 - Dispositions d'interconnexion ne comportant pas de commutation centralisée comprenant une ligne commune pour tous les groupes
10.
Methods for treating blood composition and function disorders wherein a patient's blood plasma is extracorporeally contacted with donor blood or modified donor blood
The present invention relates to a method for treating blood composition disorders and blood function disorders. Said method comprises steps, in which blood or blood plasma of a patient is brought into extracorporeal contact with a second fluid (bioequivalent), wherein said second fluid is blood or modified blood, which comprises at least granulocytes, thrombocytes, and erythrocytes. Furthermore, the invention relates to devices for performing said method and to the use of such a device or blood or modified blood, which comprises granulocytes, thrombocytes, and erythrocytes, for treating blood composition disorders and blood function disorders.
