Methods and apparatuses for applying energy to a target tissue or cell are described herein. These methods and apparatuses may use one or more pairs of stimulating electrodes and a dedicated ground electrode to locally apply energy to a target tissue or cell at or adjacent the dedicated ground electrode.
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
Disclosed herein is a method of fabrication used in conjunction with simplified fabrication process such as sheet cutting or additive material manufacturing which can cure many deficiencies of laminar bonding or assembly processes including curing of micro-voids or delamination between layers of a component, as well as enabling the combination of components to form a more complex assembly. This method includes the steps of: providing a first component having been formed of a plurality of planar layers; providing a compaction vessel; providing a granular support medium to the interior of the compaction vessel; placing the first component into the granular support medium within the compaction vessel so as to fully encompass the first component or component assembly; heating the granular support and the primary component within the compaction vessel; and applying a compaction force so as to bond or re-fuse the planar layers together.
B29C 43/36 - Moules pour la fabrication d'objets de longueur définie, c.-à-d. d'objets séparés
B29C 43/18 - Moulage par pressage, c.-à-d. en appliquant une pression externe pour faire couler la matière à moulerAppareils à cet effet pour la fabrication d'objets de longueur définie, c.-à-d. d'objets séparés en incorporant des parties ou des couches préformées, p. ex. moulage par pressage autour d'inserts ou sur des objets à recouvrir
B29C 43/20 - Fabrication d'objets multicouches ou polychromes
B29C 43/32 - Éléments constitutifs, détails ou accessoiresOpérations auxiliaires
B29K 21/00 - Utilisation de caoutchouc non spécifié ou élastomères non spécifiés comme matière de moulage
B29K 105/08 - Présentation, forme ou état de la matière moulée contenant des agents de renforcement, charges ou inserts de grande longueur, p. ex. ficelles, mèches, mats, tissus ou fils
B29K 105/14 - Présentation, forme ou état de la matière moulée contenant des agents de renforcement, charges ou inserts de longueur réduite, p. ex. filaments coupés, fibres coupées ou crins orientés
B32B 5/02 - Produits stratifiés caractérisés par l'hétérogénéité ou la structure physique d'une des couches caractérisés par les caractéristiques de structure d'une couche comprenant des fibres ou des filaments
B32B 5/12 - Produits stratifiés caractérisés par l'hétérogénéité ou la structure physique d'une des couches caractérisés par les caractéristiques de structure d'une couche comprenant des fibres ou des filaments caractérisés par la disposition relative des fibres ou filaments des couches adjacentes
B32B 5/26 - Produits stratifiés caractérisés par l'hétérogénéité ou la structure physique d'une des couches caractérisés par la présence de plusieurs couches qui comportent des fibres, filaments, grains ou poudre, ou qui sont sous forme de mousse ou essentiellement poreuses une des couches étant fibreuse ou filamenteuse un autre couche également étant fibreuse ou filamenteuse
B32B 27/12 - Produits stratifiés composés essentiellement de résine synthétique adjacente à une couche fibreuse ou filamenteuse
B32B 27/18 - Produits stratifiés composés essentiellement de résine synthétique caractérisée par l'emploi d'additifs particuliers
B33Y 40/20 - Posttraitement, p. ex. durcissement, revêtement ou polissage
3.
COMPOSITIONS AND METHODS FOR TREATING AND/OR PREVENTING LUNG INJURY
Provided are methods for treating and/or preventing diseases, disorders, and/or conditions associated with viral infections in subjects, which in some embodiments can include administering to the subject an effective amount of a PTP4A3 inhibitor. In some embodiments, the disease, disorder, and/or condition is characterized by lung damage, ALI, ARDS, or any combination thereof. Also provided are methods for reducing or inhibiting virus-induced alveolar inflammation and/or damage, methods for reducing or inhibiting induction of inflammatory cytokines and/or chemokines in subjects, methods for reducing or inhibiting pulmonary diseases, disorders, and/or conditions associated with viral infections, or pulmonary damage resulting therefrom, methods for preventing and/or treating chemical damage to lungs, uses of PTP4A3 inhibitors in the presently disclosed methods.
A61K 31/4365 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique ayant le soufre comme hétéro-atome du cycle, p. ex. ticlopidine
A61P 31/14 - Antiviraux pour le traitement des virus ARN
A61P 39/00 - Agents protecteurs généraux ou antipoisons
4.
TREATMENT OF TISSUE USING ELECTRICAL STIMULATION PULSES BASED ON NON-CANCELED ELECTRICAL OUTPUT
An apparatus for electrical stimulation of tissue includes: a first pair of electrodes configured to contact a person and convey a first AC current through tissue of the person; a second pair of electrodes configured to contact the person and convey a second AC current through tissue of the person; and a controller configured to control the first and second AC currents such that they have substantially the same frequency and substantially opposite phases except during at least one distortion that is introduced in the first AC current and/or the second AC current. The first and second pairs of electrodes are configured to be positioned on the person such that the first and second AC currents are simultaneously conveyed through target tissue of the person, where the first and second AC currents are configured to substantially cancel each other in target tissue except during the at least one distortion.
A61N 1/18 - Application de courants électriques par électrodes de contact
A61N 1/32 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
Various implementations include an ultrasound needle guidance device. The device includes a coupling body and at least one needle holder portion. The coupling body is configured to fixedly couple to an ultrasound probe that is able to produce an ultrasonic beam along a scanning plane. The needle holder portion has a rotational axis and defines a needle opening having an opening central axis extending perpendicularly to the rotational axis. The needle holder portion is rotationally coupled to the coupling body such that the needle holder portion is rotatable about the rotational axis relative to the coupling body from a first position to a second position. The needle holder portion is configured such that, when the coupling body is coupled to the ultrasound probe, the opening central axis is disposed within the scanning plane in all positions in a range from the first position to the second position.
A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles
Various implementations include an ultrasound needle guidance device. The device includes a coupling body and at least one needle holder portion. The coupling body is configured to fixedly couple to an ultrasound probe that is able to produce an ultrasonic beam along a scanning plane. The needle holder portion has a rotational axis and defines a needle opening having an opening central axis extending perpendicularly to the rotational axis. The needle holder portion is rotationally coupled to the coupling body such that the needle holder portion is rotatable about the rotational axis relative to the coupling body from a first position to a second position. The needle holder portion is configured such that, when the coupling body is coupled to the ultrasound probe, the opening central axis is disposed within the scanning plane in all positions in a range from the first position to the second position.
An apparatus and methods for performing ablation of myocardial tissues are disclosed. The apparatus includes a plurality of ablation electrode configurations to which nanosecond pulsed electric fields are applied. The methods relate to therapies to treat cardiac arrhythmias, such as, atrial fibrillation and scar-related ventricular tachycardia, amongst others. The affected myocardial tissues are ablated creating a plurality of lesions enabled by the nanosecond pulsed electric fields applied to either penetrating electrodes, endo-endo electrodes, or endo-epi electrodes. Different electrophysiological tests are performed to assess the application of nanosecond pulsed electric field ablation to specific desired tissue location within the heart. Test results show the potential to overcome limitations of current ablation therapies, thereby providing patients and doctors a superior treatment for cardiac arrhythmias.
Methods and apparatuses for applying energy to a target tissue or cell are described herein. These methods and apparatuses may use one or more pairs of stimulating electrodes and a dedicated ground electrode to locally apply energy to a target tissue or cell at or adjacent the dedicated ground electrode.
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
Methods and apparatuses are described herein for inactivation of bacterial biofilms using sub-microsecond pulsed electric field application to an affected surface or region. In some examples, a bacterial biofilm may be inactivated while planktonic bacteria in the vicinity of the biofilm are not inactivated. These methods and systems provide an electrical-based therapeutic modality for which bacteria in biofilms may have difficulty developing resistance, unlike antibiotic therapies.
A61N 1/32 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
10.
COMPOSITIONS AND METHODS FOR TREATING AND/OR PREVENTING LUNG INJURY
Provided are methods for treating and/or preventing diseases, disorders, and/or conditions associated with viral infections in subjects, which in some embodiments can include administering to the subject an effective amount of a PTP4A3 inhibitor. In some embodiments, the disease, disorder, and/or condition is characterized by lung damage, ALI, ARDS, or any combination thereof. Also provided are methods for reducing or inhibiting virus-induced alveolar inflammation and/or damage, methods for reducing or inhibiting induction of inflammatory cytokines and/or chemokines in subjects, methods for reducing or inhibiting pulmonary diseases, disorders, and/or conditions associated with viral infections, or pulmonary damage resulting therefrom, methods for preventing and/or treating chemical damage to lungs, uses of PTP4A3 inhibitors in the presently disclosed methods.
METHOD AND APPARATUS FOR FORMING VARIABLE DENSITY SINTERED CERAMIC USING APPLICATION OF ALTERNATING VOLTAGE TO AQUEOUS CERAMIC SUSPENSION WITH ICE-TEMPLATING
A method and apparatus for forming variable density ceramic structures, where the method includes: obtaining a ceramic powder having an ultrafine particle size; mixing the ceramic powder into a suspension fluid thus forming a ceramic suspension; providing a mold configured to retain the ceramic suspension; providing a plurality of electrodes about the mold; applying an alternating voltage to the electrodes thus forming alternating electric currents through the suspension thus causing accumulation of ceramic particles on at least one of the electrodes; reducing the temperature of the suspension thus inducing the formation of ice crystals therein necessary for ice-templating; freeze drying the frozen suspension into a porous state; and sintering the ceramic particles into a solid architecture retaining a common final structure with the ceramic particles in the porous state.
A system and method for the detection and system impact mitigation of bots in Internet of Things (IoT) devices, the system including a smart auditor configured to interface with and control a power supply of an IoT device, the smart auditor being configured to measure and transmit power usage information of the IoT device. The system then utilizing a historical database and various IoT devices and associated power usage patterns to identify anomalies in power usage by the IoT device based on historical data, utilize machine learning to recognize normal and non-normal power usage patterns, and generate a command to shut off power to the IoT device upon detection of malicious botnet activity. The system including encryption protocols to maintain privacy during communication of the power usage information as well as maintain integrity and secrecy regarding model information from the historical database.
Methods and apparatuses are described herein for inactivation of bacterial biofilms using sub-microsecond pulsed electric field application to an affected surface or region. In some examples, a bacterial biofilm may be inactivated while planktonic bacteria in the vicinity of the biofilm are not inactivated. These methods and systems provide an electrical-based therapeutic modality for which bacteria in biofilms may have difficulty developing resistance, unlike antibiotic therapies.
A61N 1/32 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
A61B 18/12 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage en faisant passer des courants à travers les tissus à chauffer, p. ex. des courants à haute fréquence
A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
14.
Targeted remote electrostimulation by interference of bipolar nanosecond pulses
Provided herein are methods of generating a biologically effective unipolar nanosecond electric pulse by superposing two biologically ineffective bipolar nanosecond electric pulses and related aspects, such as electroporation and/or therapeutic applications of these methods to non-invasively target electrostimulation (ES) selectively to deep tissues and organs.
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
C12N 13/00 - Traitement de micro-organismes ou d'enzymes par énergie électrique ou ondulatoire, p. ex. par magnétisme, par des ondes sonores
Systems and methods of enhancing membrane permeabilization in a cell are provided. An example method includes disposing the cell between a first electrode and a second electrode and applying a plurality of electrical pulses between the first electrode and the second electrode. In the systems and methods, the plurality of electrical pulses include at least two trains of pulses separated by an interval greater than about 10 s. Further, the amplitude of the electrical pulses is selected to be greater than about 0.2 kV/cm.
A method and system for delivering a molecule to a specific area of a tissue by controlling temperature and impedance is presented. The method is generally comprised of applying heat to a biological structure, such as cells or tissues, to heat the biological structure to a preset temperature after which at least one electroporation pulse is administered to the biological structure. Impedance is measured as a feedback control mechanism after each pulse and pulse parameters are adjusted accordingly until desired impedance is reached. The system generally comprises an electroporation system capable of generating at least one pulse, measuring impedance and measuring temperature. The method may be used to deliver a molecule such as a vaccine or therapeutic to a biological structure, such as for prevention or treatment of SARS-CoV-2 infection.
An apparatus and methods for performing ablation of myocardial tissues are disclosed. The apparatus includes a plurality of ablation electrode configurations to which nanosecond pulsed electric fields are applied. The methods relate to therapies to treat cardiac arrhythmias, such as, atrial fibrillation and scar-related ventricular tachycardia, amongst others. The affected myocardial tissues are ablated creating a plurality of lesions enabled by the nanosecond pulsed electric fields applied to either penetrating electrodes, endo-endo electrodes, or endo-epi electrodes. Different electrophysiological tests are performed to assess the application of nanosecond pulsed electric field ablation to specific desired tissue location within the heart. Test results show the potential to overcome limitations of current ablation therapies, thereby providing patients and doctors a superior treatment for cardiac arrhythmias.
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
18.
Targeted delivery of molecules using impedance-based monitoring at elevated temperatures
A method and system for delivering a molecule to a specific area of a tissue by controlling temperature and impedance is presented. The method is generally comprised of applying heat to a biological structure, such as cells or tissues, to heat the biological structure to a preset temperature after which at least one electroporation pulse is administered to the biological structure. Impedance is measured as a feedback control mechanism after each pulse and pulse parameters are adjusted accordingly until desired impedance is reached. The system generally comprises an electroporation system capable of generating at least one pulse, measuring impedance and measuring temperature.
Resistively loaded dielectric biconical antenna apparatuses, including systems and devices, that may be used to transmit very short electrical pulses (e.g., nanosecond, sub-nanosecond, picosecond, etc.) into tissue non-invasively at energy levels sufficient to invoke biological changes in the tissue. These resistively loaded dielectric biconical antenna apparatuses may include a resistor ring reducing internal reflection and reducing energy loss, as well as delivering longer pulses (e.g. microsecond to millisecond) to tissue.
H01Q 13/24 - Antennes constituées par un guide non résonnant à ondes de fuite ou une ligne de transmissionStructures équivalentes produisant un rayonnement le long du trajet de l'onde guidée constitué par une tige ou un tube diélectrique ou ferromagnétique
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs
Aspects of the subject disclosure may include, for example, a method comprising sending context information from a mobile wireless device through a control channel to a network server; receiving a policy at the mobile wireless device from the network server, wherein the policy assigns a video streaming bit rate to the mobile wireless device based on the context information; and implementing the policy to control a video streaming session between the mobile wireless device and a media server over a data channel. The context information may include information about the mobile wireless device and/or a user of the mobile wireless device. The policy may be different for each mobile wireless device. Other embodiments are disclosed.
Methods and apparatuses (systems, devices, etc.) for treating biological tissue to evoke one or more desirable biological and/or physiological effects using pulsed electric fields in the sub-microsecond range at very low electric field strength (e.g., less than 1 kV/cm) but at high (e.g., megahertz) frequencies.
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
A61N 1/08 - Aménagements ou circuits de surveillance, de protection, de commande ou d'indication
Methods and apparatuses (systems, devices, etc.) for treating biological tissue to evoke one or more desirable biological and/or physiological effects using pulsed electric fields in the sub-microsecond range at very low electric field strength (e.g., less than 1 kV/cm) but at high (e.g., megahertz) frequencies.
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
A61B 18/12 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage en faisant passer des courants à travers les tissus à chauffer, p. ex. des courants à haute fréquence
A61N 1/40 - Application de champs électriques par couplage inductif ou capacitif
Methods and apparatuses (systems, devices, etc.) for treating biological tissue to evoke one or more desirable biological and/or physiological effects using pulsed electric fields in the sub-microsecond range at very low electric field strength (e.g., less than 1 kV/cm) but at high (e.g., megahertz) frequencies.
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
A61N 1/40 - Application de champs électriques par couplage inductif ou capacitif
A61B 18/12 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage en faisant passer des courants à travers les tissus à chauffer, p. ex. des courants à haute fréquence
24.
TARGETED REMOTE ELECTROSTIMULATION BY INTERFERENCE OF BIPOLAR NANOSECOND PULSES
Provided herein are methods of generating a biologically effective unipolar nanosecond electric pulse by superposing two biologically ineffective bipolar nanosecond electric pulses and related aspects, such as electroporation and/or therapeutic applications of these methods to non-invasively target electrostimulation (ES) selectively to deep tissues and organs.
A61B 18/12 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage en faisant passer des courants à travers les tissus à chauffer, p. ex. des courants à haute fréquence
Provided herein are methods of generating a biologically effective unipolar nanosecond electric pulse by superposing two biologically ineffective bipolar nanosecond electric pulses and related aspects, such as electroporation and/or therapeutic applications of these methods to non-invasively target electrostimulation (ES) selectively to deep tissues and organs.
A61N 1/32 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
Provided herein are methods of generating a biologically effective unipolar nanosecond electric pulse by superposing two biologically ineffective bipolar nanosecond electric pulses and related aspects, such as electroporation and/or therapeutic applications of these methods to non-invasively target electrostimulation (ES) selectively to deep tissues and organs.
A61B 18/12 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage en faisant passer des courants à travers les tissus à chauffer, p. ex. des courants à haute fréquence
Systems and methods for treatment of a biological tissues including target tissues and other tissues. The method includes elevating a temperature of the target tissues above a physiological temperature of the biological tissues to treatment temperature, and generating an electric field extending through at least a portion of the target tissues using a pre-defined sequence of short voltage pulses applied between at least two electrodes. In the method, the treatment temperature is maintained during the generating. Further, the pre-defined sequence is selected such that a magnitude of the electric field generated is sufficient to induce electromanipulation in the portion of the target tissues without substantially elevating of the temperature of the portion of the target tissues above the treatment temperature.
A61B 18/12 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage en faisant passer des courants à travers les tissus à chauffer, p. ex. des courants à haute fréquence
A61N 1/40 - Application de champs électriques par couplage inductif ou capacitif
A61N 1/32 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents
A61N 5/02 - Thérapie par radiations utilisant des hyperfréquences
A61N 5/06 - Thérapie par radiations utilisant un rayonnement lumineux
A61B 18/18 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par application de radiations électromagnétiques, p. ex. de micro-ondes
A61B 18/20 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par application de radiations électromagnétiques, p. ex. de micro-ondes en utilisant des lasers
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
A61N 5/067 - Thérapie par radiations utilisant un rayonnement lumineux utilisant un rayonnement laser
A61B 18/24 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par application de radiations électromagnétiques, p. ex. de micro-ondes en utilisant des lasers le faisceau étant dirigé le long, ou à l'intérieur d'un conduit flexible, p. ex. d'une fibre optiquePièces à main à cet effet avec un cathéter
28.
Treatment of biological tissues using subnanosecond electric pulses
A system for treatment of biological tissues is provided. The system can deliver electric pulses to a targeted region within a biological tissue. The system includes an antenna assembly and a lens. The antenna assembly is configured to generate and direct electromagnetic radiation. The lens is configured to be positioned between a surface of the biological tissue and the antenna assembly. The lens can have a plurality of lossy portions. The lens can be configured to be adjustable to create a patient-specific desired electric field distribution by selective positioning of the plurality of lossy portions within the lens.
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
Methods of enhancing membrane permeabilization in a cell are provided. A method includes disposing the cell between a first electrode and a second electrode and applying a plurality of electrical pulses between the first electrode and the second electrode. In the method, the plurality of electrical pulses include at least two trains of pulses separated by an interval greater than about 10 s. Further, the amplitude of the electrical pulses is selected to be greater than about 0.2 kV/cm.
Methods for a new, drug-free therapy for treating solid skin tumors through the application of nanosecond pulsed electric fields (“nsPEFs”) are provided. In one embodiment of the invention, the cells are melanoma cells, and the applied nsPEFs penetrate into the interior of tumor cells and cause tumor cell nuclei to rapidly shrink and tumor blood flow to stop. This new technique provides a highly localized targeting of tumor cells with only minor effects on overlying skin.
An apparatus and methods for performing ablation of myocardial tissues are disclosed. The apparatus includes a plurality of ablation electrode configurations to which nanosecond pulsed electric fields are applied. The methods relate to therapies to treat cardiac arrhythmias, such as, atrial fibrillation and scar-related ventricular tachycardia, amongst others. The affected myocardial tissues are ablated creating a plurality of lesions enabled by the nanosecond pulsed electric fields applied to either penetrating electrodes, endo-endo electrodes, or endo-epi electrodes. Different electrophysiological tests are performed to assess the application of nanosecond pulsed electric field ablation to specific desired tissue location within the heart. Test results show the potential to overcome limitations of current ablation therapies, thereby providing patients and doctors a superior treatment for cardiac arrhythmias.
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
32.
METHODS AND DEVICES FOR TREATMENT OF TUMORS WITH NANO-PULSE STIMULATION
Disclosed herein are methods and devices for stimulating an immune response to a disease in a subject, which involves passing sub-microsecond long pulses of electric fields having an amplitude between 5 kV/cm and 68 kV/cm through an abnormal growth of a subject sufficient to suppress myeloid-derived suppressor cell (MDSC) or regulatory T cell (Treg) production, increase adenosine triphosphate (ATP) or high mobility group box 1 (HMGB1) production, or stimulate dendritic cell activation in the subject.
A61N 1/32 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents
A61B 18/12 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage en faisant passer des courants à travers les tissus à chauffer, p. ex. des courants à haute fréquence
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
33.
Multi-electrode electrical pulse delivery system for treatment of biological tissues
Systems and methods for treating or manipulating biological tissues are provided. In the systems and methods, a biological tissue is placed in contact with an array of electrodes. Electrical pulses are then applied between a bias voltage bus and a reference voltage bus of a distributor having switching elements associated with each of the electrodes. The switching elements provide a first contact position for coupling electrodes to bias voltage bus, a second contact position for coupling electrodes to the reference voltage bus, and a third contact position for isolating electrodes from the high and reference voltage buses. The switching elements are operated over various time intervals to provide the first contact position for first electrodes, a second contact position for second electrodes adjacent to the first electrodes, and a third contact position for a remainder of the electrodes adjacent to the first and second electrodes.
A61B 18/12 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage en faisant passer des courants à travers les tissus à chauffer, p. ex. des courants à haute fréquence
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
34.
Methods and devices for using sub-microsecond electric pulses to trigger apoptosis
The methods disclosed herein are directed towards improving ablation efficiency associated with applying nanosecond electric pulses (nsEP) to tissue. In particular, applying nsEP to tissue can open pores in the cellular membranes of the tissue. These pores can be kept open longer by cooling the tissue. The combined application of nsEP and the cooling of tissue may have synergistic effects on triggering apoptosis of cells in the tissue. This allows for numerous practical benefits associated with nsEP-based tissue ablation to be realized. For instance, nsEP of lower pulse strength or lower numbers of pulses to be used, which can be provided by smaller pulse generators operating on less power.
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
A61B 18/02 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par refroidissement, p. ex. techniques cryogéniques
A61B 18/12 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage en faisant passer des courants à travers les tissus à chauffer, p. ex. des courants à haute fréquence
35.
METHODS AND DEVICES FOR USING SUB-MICROSECOND ELECTRIC PULSES TO TRIGGER APOPTOSIS
The methods disclosed herein are directed towards improving ablation efficiency associated with applying nanosecond electric pulses (nsEP) to tissue. In particular, applying nsEP to tissue can open pores in the cellular membranes of the tissue. These pores can be kept open longer by cooling the tissue. The combined application of nsEP and the cooling of tissue may have synergistic effects on triggering apoptosis of cells in the tissue. This allows for numerous practical benefits associated with nsEP-based tissue ablation to be realized. For instance, nsEP of lower pulse strength or lower numbers of pulses to be used, which can be provided by smaller pulse generators operating on less power.
A61B 18/12 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage en faisant passer des courants à travers les tissus à chauffer, p. ex. des courants à haute fréquence
A61B 18/02 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par refroidissement, p. ex. techniques cryogéniques
36.
Low-energy defibrillation with nanosecond pulsed electric fields
Methods for terminating fibrillation in a fibrillating heart employing nanosecond pulsed electric fields (nsPEFs) are disclosed. nsPEF defibrillation demonstrates its effectiveness as a new defibrillation modality, achieving reliable defibrillation with energies that are an order of magnitude lower than those needed for conventional defibrillation (millisecond shocks with mono- and bi-phasic waveforms). Tests did not reveal any negative effect of nsPEF defibrillation on cardiac tissue, in particular, cardiac tissue treated with nsPEFs does not exhibit a baseline shift in the optical transmembrane potential signal (distinctive feature that indicates electroporation), or changes in action potential duration or shape. The mechanism of nsPEF defibrillation is likely different from conventional defibrillation since it does not rely on membrane charging but on the basis of displacement currents that flow within nanoseconds after the shock is applied. nsPEFs provide the technology for the next generation of defibrillators that help emergency medical services to treat patients effectively.
A method and apparatus are provided for delivering an agent into a cell through the application of nanosecond pulse electric fields (“nsPEF's”). The method includes circuitry for delivery of an agent into a cell via known methods followed by the application of nanosecond pulse electric fields to said cell in order to facilitate entry of the agent into the nucleus of the cell. In a preferred embodiment, the present invention is directed to a method of enhancing gene expression in a cell comprising the application of nanosecond pulse electric fields to said cell. An apparatus for generating long and short pulses according to the present invention is also provided. The apparatus includes a pulse generator capable of producing a first pulse having a long duration and low voltage amplitude and a second pulse having a short duration and high voltage amplitude.
A61N 1/32 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents
C12M 1/42 - Appareils pour le traitement de micro-organismes ou d'enzymes au moyen d'énergie électrique ou ondulatoire, p. ex. magnétisme, ondes sonores
C12N 15/87 - Introduction de matériel génétique étranger utilisant des procédés non prévus ailleurs, p. ex. co-transformation
C12N 13/00 - Traitement de micro-organismes ou d'enzymes par énergie électrique ou ondulatoire, p. ex. par magnétisme, par des ondes sonores
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
38.
System and methods of treatment using electromagnetic illumination
A method of inducing local cell death in patient tissue is provided. The method includes generating first and second radiation, conveying the radiation to a focusing element, and focusing the radiation on a target with the focusing element. A system for inducing local cell death in patient tissue is also provided. The system includes a power source for generating narrowband and/or ultra-wideband radiation, and a focusing element for focusing the radiation on a target.
A61B 18/18 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par application de radiations électromagnétiques, p. ex. de micro-ondes
A system for treatment of biological tissues is provided. The system includes a lens having a hollow, substantially hemispherical shape with an outer surface and an inner surface, the inner surface defining a substantially hemispherical cavity for inserting the biological tissues. The system further includes an antenna assembly for generating and directing electromagnetic radiation towards the outer surface. In the system, the lens is configured to direct the electromagnetic energy to an area in the cavity, a dielectric constant of the lens at the inner surface substantially matches a dielectric constant of the biological tissues, the dielectric constant monotonically increases from the outer surface to the inner surface, and the electromagnetic energy is generated via a series of pulses having a transient of less than about 1 nanosecond.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
A61N 1/40 - Application de champs électriques par couplage inductif ou capacitif
Catheter devices can include an elongate housing extending along a major axis, the elongate housing comprising a first end an opening. The catheter devices can also include an electrode assembly disposed in the elongate housing and including deformable electrodes with respective electrode distal ends, where the electrode distal ends each consist of respective member portions and respective tip portions. The electrode assembly is slidably movable within the housing along the major axis to allow the electrode distal end portions to transition between a first retracted position and a second extended position. The catheter device is configured such that an average distance between the tip portions in the second position is configured to be greater than an average distance between the tip portions in the first position the tip portions are positioned substantially in a same plane when the electrode assembly is in the second position.
A61B 1/00 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments
A61N 1/32 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
A61B 1/018 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments caractérisés par les conduits internes ou par leurs accessoires destinés à recevoir des instruments
A61B 1/04 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments combinés avec des dispositifs photographiques ou de télévision
A61B 1/06 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments avec dispositifs d'éclairement
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
A61B 18/12 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage en faisant passer des courants à travers les tissus à chauffer, p. ex. des courants à haute fréquence
41.
Radio frequency plasma method for uniform surface processing of RF cavities and other three-dimensional structures
A method for efficient plasma etching of surfaces inside three-dimensional structures can include positioning an inner electrode within the chamber cavity; evacuating the chamber cavity; adding a first inert gas to the chamber cavity; regulating the pressure in the chamber; generating a plasma sheath along the inner wall of the chamber cavity; adjusting a positive D.C. bias on the inner electrode to establish an effective plasma sheath voltage; adding a first electronegative gas to the chamber cavity; optionally readjusting the positive D.C. bias on the inner electrode reestablish the effective plasma sheath voltage at the chamber cavity; etching the inner wall of the chamber cavity; and polishing the inner wall to a desired surface roughness.
Methods for treating tumors employing HSp90 inhibitors in combination with nanosecond pulsed electric fields (nsPEFs) are disclosed. The methods are directed to induce regulated cell death (RCD) in tumor cells and tissues. Further, Hsp90 inhibitors in combination with nsPEF are used at low non-toxic concentrations, thereby reducing the side-effects associated with these drugs. Additionally, nsPEFs are employed at lower electric fields and/or with fewer number of pulses than when nsPEFs are employed alone. Further, the mechanisms by which nsPEFs and Hsp90 inhibitors act upon cancer cells are different, thereby combining these treatments results in a synergistic effect.
A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
43.
LOW-ENERGY DEFIBRILLATION WITH NANOSECOND PULSED ELECTRIC FIELDS
Methods for terminating fibrillation in a fibrillating heart employing nanosecond pulsed electric fields (nsPEFs) are disclosed. nsPEF defibrillation demonstrates its effectiveness as a new defibrillation modality, achieving reliable defibrillation with energies that are an order of magnitude lower than those needed for conventional defibrillation (millisecond shocks with mono- and bi-phasic waveforms). Tests did not reveal any negative effect of nsPEF defibrillation on cardiac tissue, in particular, cardiac tissue treated with nsPEFs does not exhibit a baseline shift in the optical transmembrane potential signal (distinctive feature that indicates electroporation), or changes in action potential duration or shape. The mechanism of nsPEF defibrillation is likely different from conventional defibrillation since it does not rely on membrane charging but on the basis of displacement currents that flow within nanoseconds after the shock is applied. nsPEFs provide the technology for the next generation of defibrillators that help emergency medical services to treat patients effectively.
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
An imaging and recordation system is provided. The system includes a high-power, focusing antenna for illuminating biological tissue. The system further includes a power source for powering the antenna. The system further includes a data acquisition module, for recording the dielectric properties of tissues illuminated by the high-power, focusing antenna. The system illuminates the tissues using ultrashort electrical pulses.
A61B 5/05 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio
The present disclosure describes methods for intracellular electromanipulation of proteins using nanosecond pulsed electric fields (nsPEFs). The nsPEFs have effects on proteins in addition to permeabilizing cellular membranes. The nsPEFs induce a Ca2+-dependent dissipation of the mitochondria membrane potential (ΔΨm), which is enhanced when high frequency components are present in fast rise-fall waveforms. Ca2+ is shown to have little or no effect on propidium iodide uptake as a measure of plasma membrane poration and consequently intracellular membranes. Since Ca2+-regulated events are mediated by proteins, actions of nsPEFs on proteins that regulate and/or affect the mitochondria membrane potential are possible. Given that nsPEF-induced dissipation of ΔΨm was more effective when high frequency components were present in fast rise time waveforms, the effects on proteins are due to these high frequency components. These results present direct evidence that nsPEFs affect proteins and their functions by affecting their structure.
Methods for a new, drug-free therapy for treating solid skin tumors through the application of nanosecond pulsed electric fields (“nsPEFs”) are provided. In one embodiment of the invention, the cells are melanoma cells, and the applied nsPEFs penetrate into the interior of tumor cells and cause tumor cell nuclei to rapidly shrink and tumor blood flow to stop. This new technique provides a highly localized targeting of tumor cells with only minor effects on overlying skin.
Catheter devices can include an elongate housing extending along a major axis, the elongate housing comprising a first end an opening. The catheter devices can also include an electrode assembly disposed in the elongate housing and including deformable electrodes with respective electrode distal ends, where the electrode distal ends each consist of respective member portions and respective tip portions. The electrode assembly is slidably movable within the housing along the major axis to allow the electrode distal end portions to transition between a first retracted position and a second extended position. The catheter device is configured such that an average distance between the tip portions in the second position is configured to be greater than an average distance between the tip portions in the first position the tip portions are positioned substantially in a same plane when the electrode assembly is in the second position.
Catheter devices can include an elongate housing extending along a major axis, the elongate housing comprising a first end an opening. The catheter devices can also include an electrode assembly disposed in the elongate housing and including deformable electrodes with respective electrode distal ends, where the electrode distal ends each consist of respective member portions and respective tip portions. The electrode assembly is slidably movable within the housing along the major axis to allow the electrode distal end portions to transition between a first retracted position and a second extended position. The catheter device is configured such that an average distance between the tip portions in the second position is configured to be greater than an average distance between the tip portions in the first position the tip portions are positioned substantially in a same plane when the electrode assembly is in the second position.
An apparatus and methods for performing ablation of myocardial tissues are disclosed. The apparatus includes a plurality of ablation electrode configurations to which nanosecond pulsed electric fields are applied. The methods relate to therapies to treat cardiac arrhythmias, such as, atrial fibrillation and scar-related ventricular tachycardia, amongst others. The affected myocardial tissues are ablated creating a plurality of lesions enabled by the nanosecond pulsed electric fields applied to either penetrating electrodes, endo-endo electrodes, or endo-epi electrodes. Different electrophysiological tests are performed to assess the application of nanosecond pulsed electric field ablation to specific desired tissue location within the heart. Test results show the potential to overcome limitations of current ablation therapies, thereby providing patients and doctors a superior treatment for cardiac arrhythmias.
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
50.
Method for making multiple walled nested coaxial nanostructures
Methods for making multiple walled nested coaxial nanostructures and devices incorporating the coaxial nanostructures are disclosed. The coaxial nanostructures include an inner nanostructure, a first outer nanotube disposed around the inner nanostructure, and a first annular channel between the inner nanostructure and the first outer nanotube. The coaxial nanostructures have extremely high aspect ratios, ranging from about 5 to about 1,200, or about 300 to about 1200.
B01D 67/00 - Procédés spécialement adaptés à la fabrication de membranes semi-perméables destinées aux procédés ou aux appareils de séparation
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétésProcédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
C23C 16/01 - Revêtement chimique par décomposition de composés gazeux, ne laissant pas de produits de réaction du matériau de la surface dans le revêtement, c.-à-d. procédés de dépôt chimique en phase vapeur [CVD] sur des substrats temporaires, p. ex. sur des substrats qui sont ensuite enlevés par attaque chimique
F04B 19/00 - "Machines" ou pompes ayant des caractéristiques particulières non prévues dans les groupes ou présentant un intérêt autre que celui visé par ces groupes
51.
Electromanipulation of cells and other biological tissues by pulsed electric fields at elevated temperatures
Systems and methods for treatment of a biological tissues comprising target tissues and other tissues. The method includes elevating a temperature of the target tissues above a physiological temperature of the biological tissues to treatment temperature, and generating an electric field extending through at least a portion of the target tissues using a pre-defined sequence of short voltage pulses applied between at least two electrodes. In the method, the treatment temperature is maintained during the generating. Further, the pre-defined sequence is selected such that a magnitude of the electric field generated is sufficient to induce electromanipulation in the portion of the target tissues without substantially elevating of the temperature of the portion of the target tissues above the treatment temperature.
A61N 1/30 - Appareils d'ionothérapie ou d'électrophorèse
A61B 18/12 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage en faisant passer des courants à travers les tissus à chauffer, p. ex. des courants à haute fréquence
A61N 1/40 - Application de champs électriques par couplage inductif ou capacitif
A61N 1/32 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents
A61N 5/02 - Thérapie par radiations utilisant des hyperfréquences
A61N 5/06 - Thérapie par radiations utilisant un rayonnement lumineux
A61B 18/18 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par application de radiations électromagnétiques, p. ex. de micro-ondes
A61B 18/20 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par application de radiations électromagnétiques, p. ex. de micro-ondes en utilisant des lasers
A61B 18/24 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par application de radiations électromagnétiques, p. ex. de micro-ondes en utilisant des lasers le faisceau étant dirigé le long, ou à l'intérieur d'un conduit flexible, p. ex. d'une fibre optiquePièces à main à cet effet avec un cathéter
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
A61N 5/067 - Thérapie par radiations utilisant un rayonnement lumineux utilisant un rayonnement laser
52.
GREEN PROCESS TO HYDROLYZE CARBOHYDRATES FROM TOBACCO BIOMASS USING SUBCRITICAL WATER
Processes for recovering sugars and nicotine from a tobacco biomass include feeding a biomass of tobacco plants and subcritical water to a reactor (20), hydrolyzing the biomass of tobacco plants with the subcritical water at a temperature between about 150°C and 305°C and recovering a liquid product and a solid product from the reactor, wherein the liquid product contains water-soluble sugars and nicotine.
A system and method for detecting and isolating a shadow of buildings or structures of interest within an input image. The building or structure of interest is localized by the system using region based geometric active contour modeling, and the present approach is able to overcome complexity of pattern and structure by a sequence of global and local processing to remove image data from clutter.
Described herein are carboxylated biochar compositions and methods for creating advanced biochar materials with higher cation exchange capacity and free of potential toxic components for use as filtration materials and as biochar soil amendment and carbon sequestration agent to help control climate change for energy and environmental sustainability on Earth.
OLD DOMINION UNIVERSITY RESEARCH FOUNDATION, (USA)
Inventeur(s)
Knisley, Dr. Stephen
Abrégé
A device is provided for measuring the progress of a treatment for pectus excavatum, the treatment incorporating an implanted elongated pectus bar having ends defining and end-to-end distance. The device includes a caliper for measuring the end-to-end distance of the pectus bar and a device for determining sternal force in part from the change in end-to-end distance.
Described herein are fertilizers for enhancing the carbon sequestration properties of soil. The fertilizers described herein include algae comprising algaenan. In one aspect, the fertilizer includes (a) one or more organic nitrogen sources, (b) one or more synthetic nitrogen sources, and (c) algae comprising algaenan. The fertilizers and fertilizer compositions release nitrogen at a predictable rate over time, which can enhance growth of plants that are fertile with the composition described herein.
A system for treatment of biological tissues is provided. The system includes a lens having a hollow, substantially hemispherical shape with an outer surface and an inner surface, the inner surface defining a substantially hemispherical cavity for inserting the biological tissues. The system further includes an antenna assembly for generating and directing electromagnetic radiation towards the outer surface. In the system, the lens is configured to direct the electromagnetic energy to an area in the cavity, a dielectric constant of the lens at the inner surface substantially matches a dielectric constant of the biological tissues, the dielectric constant monotonically increases from the outer surface to the inner surface, and the electromagnetic energy is generated via a series of pulses having a transient of less than about 1 nanosecond.
Provided herein are methods of optimizing energy recovery from oilseeds. The methods disclosed provide at least the ability to swell oilseeds and disrupt the cell walls (hulls) without changing the functionality and quality of oil; the process integration of oil extraction and green coal production to maximize the energy recovery in the form of crude oil and green coal from oilseeds; and heat integration during processing stages including subcritical water pretreatment, oil extraction, and subcritical water carbonization to minimize the process heat requirement.
OLD DOMINION UNIVERSITY REASEARCH FOUNDATION (USA)
Inventeur(s)
Foteinos, Panagiotis
Chrisochoides, Nikos
Abrégé
A system, recording medium, and methods therefor for generating mesh from an image. The method includes processing a parallel real-time Image-to-Mesh conversion using an algorithm (PI2M) for processing an image; wherein the system is configured to process the image without surface extraction pre-processing. The method includes recovering boundaries for an image and generating meshes through a sequence of dynamic insertion and deletion of points in a Delaunay fashion. The image can be a three-dimensional medical image. The system implementing the method can be configured to process images for at least one of finite element analysis, simulation, interpolation, computer vision, or robotics.
OLD DOMINION UNIVERSITY REASEARCH FOUNDATION (USA)
Inventeur(s)
Foteinos, Panagiotis
Chrisochoides, Nikos
Abrégé
A system, recording medium, and methods therefor for generating mesh from an image. The method includes meshing a 4D medical image, and simulating a time-evolving medical condition with the 4D medical image. The method comprises recovering an underlying hyper- surface of a moving object; and filling the volume of the hyper-surface with sliver free pentatopes. The system implementing the method can be configured to process images for at least one of finite element analysis, simulation, interpolation, computer vision, or robotics
A system, method, device, and non-transitory computer readable recording medium storing a program, for processing brain image data using a three-variable solver, the variables being a Point Correspondence, a Deformation Field, and a Resection Region, and resolving the three variables with a Nested Expectation and Maximization (NEM) framework.
A61B 5/05 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio
A61B 19/00 - Instruments, outillage ou accessoires pour la chirurgie ou le diagnostic non couverts par l'un des groupes A61B 1/00-A61B 18/00, p.ex. pour stéréotaxie, opération aseptique, traitement de la luxation, protecteurs des bords des blessures(masques de protection du visage A41D 13/11; blouses de chirurgien ou vêtements pour malades A41D 13/12; dispositifs pour retirer, traiter ou transporter les liquides du corps A61M 1/00)
G06K 9/00 - Méthodes ou dispositions pour la lecture ou la reconnaissance de caractères imprimés ou écrits ou pour la reconnaissance de formes, p.ex. d'empreintes digitales
62.
A POLYMER-BASED MICROFLUIDIC RESISTIVE SENSOR FOR DETECTING DISTRIBUTED LOADS, METHODS, AND PROCESSES FOR FABRICATING THE SAME
OLD DOMINION UNIVERSITY REASEARCH FOUNDATION (USA)
Inventeur(s)
Hao, Julie (zhili)
Beskok, Ali
Cheng, Peng
Gu, Wenting
Ghosh, Arindam
Liao, Boxiong
Liao, Yuxi
Abrégé
A device, method, and process for fabricating a sensor comprising a polymer-based microfluidic sensing platform for detecting distributed loads. The sensing platform comprises a polymer microstructure; and an electrolyte-enabled distributed transducer. The electrolyte-enabled distributed transducer comprises: a microchannel formed in the unitary polymer microstructure configured to hold an electrolyte; and an electrode underneath the microchannel. The microfluidic sensing platform is configured to detect distributed loads at the micron-millimeter scale.
G01L 1/20 - Mesure des forces ou des contraintes, en général en mesurant les variations de la résistance ohmique des matériaux solides ou des fluides conducteurs de l'électricitéMesure des forces ou des contraintes, en général en faisant usage des cellules électrocinétiques, c.-à-d. des cellules contenant un liquide, dans lesquelles un potentiel électrique est produit ou modifié par l'application d'une contrainte
63.
PRODUCTION OF HYDROCARBONS FROM SELECT COAL AND ALGAL BIOMASS MIXTURES
Hydrocarbons suitable for commercial use or further refining are produced by a process that mixes an aliphatic-rich biomass and coal to obtain a feedstock. The feedstock is then subjected to a conversion process to produce a product mixture. The bio-oil, or hydrocarbons, is separated from the resulting product mixture for use or further processing. Separating the bio-oil can be done, for example, using liquid-liquid extraction to obtain an organic phase comprising the bio-oil, an aqueous phase and a solid residue. Also provided is a feedstock comprising an aliphatic-rich biomass and coal.
C10G 3/00 - Production de mélanges liquides d'hydrocarbures à partir de matières organiques contenant de l'oxygène, p. ex. huiles, acides gras
C10G 1/02 - Production de mélanges liquides d'hydrocarbures à partir de schiste bitumineux, de sable pétrolifère ou de matières carbonées solides non fusibles ou similaires, p. ex. bois, charbon par distillation
C10L 1/32 - Combustibles carbonés liquides consistant en suspensions charbon-huile ou émulsions aqueuses
An adiabatic logic family that is suitable for use with a dual-phase sinusoidal power clock as the driver. The core of all circuits in this family consists of two pMOS transistors, PI and P2, and two nMOS transistors, N3 and N4, These transistors provide the drive that provides the circuit outputs, which are complementary outputs in all cases. The logic function and its complement are specified by nMOS switching circuits that connect to N3 and N4 respectively. Unlike other adiabatic families, where the logic function switching networks are in the same path as the output networks, the proposed family decouples the logic function from the core driver circuit. The adiabatic logic family can achieve substantial reductions in energy dissipation when compared to traditional CMOS circuits.
H03K 19/08 - Circuits logiques, c.-à-d. ayant au moins deux entrées agissant sur une sortieCircuits d'inversion utilisant des éléments spécifiés utilisant des dispositifs à semi-conducteurs
Methods of enhancing membrane permeabilization in a cell are provided. A method includes disposing the cell between a first electrode and a second electrode and applying a plurality of electrical pulses between the first electrode and the second electrode. In the method, the plurality of electrical pulses include at least two trains of pulses separated by an interval greater than about 10 s. Further, the amplitude of the electrical pulses is selected to be greater than about 0.2 kV/cm.
Gas treatment systems and methods are provided. A system includes at least one device defining a space and having a gas inlet and a gas outlet. The device also includes an electrode assembly, where the electrode assembly includes a dielectric plate, at least one first electrode, at least one second electrode, and a conductive layer. The electrodes are elongate electrodes disposed on a first major surface of the dielectric plate and arranged substantially in parallel. Further, the conductive layer extends over a second major surface of the dielectric plate, is electrically coupled to the one of the electrodes, and is electrically isolated from the other electrode. The system includes a circuit configured for generating a pulsed electric field between the electrodes.
B01J 19/00 - Procédés chimiques, physiques ou physico-chimiques en généralAppareils appropriés
C01B 3/10 - Production d'hydrogène ou de mélanges gazeux contenant de l'hydrogène par réaction de composés inorganiques comportant un hydrogène lié électropositivement, p. ex. de l'eau, des acides, des bases, de l'ammoniac, avec des agents réducteurs inorganiques avec des métaux par réaction de la vapeur d'eau avec des métaux
67.
METHOD AND SYSTEM FOR AUTOMATED DENTAL IMPLANTATION
An automated dental implantation method and system using an image-guided robotic system in order to insure the accurate insertion of a dental implant within a patient's jaw bone. Patient-specific 3D models are reconstructed from preoperative Cone-beam CT images and implantation planning is performed with the virtual models. A two-step registration procedure is applied to transform the preoperative plan of the implant insertion into intra-operative operations of a robot. The two-step registration process includes registration between a virtual coordinate system and a reference coordinate system and registration between the reference coordinate system and an operation coordinate system in order to avoid direct contact between the robot and the patient during the setup stage, thus ensuring the safety of the patient.
A61C 8/00 - Moyens destinés à être fixés à l'os de la mâchoire pour consolider les dents naturelles ou pour y assujettir des prothèses dentairesImplants dentairesOutils pour l'implantation
68.
METHOD AND DEVICE FOR NATURAL ROOT FORM DENTAL IMPLANTS
A one-piece dental implant consisting of multiple roots to provide long term stability. The surface area of the dental implant can be of various configurations, peaks, dimples, cavities and grooves, vertical or horizontal, to allow for attachment in the biological environment. The surface of the dental implant has a precision engineered 3-dimensional bio-material scaffold attached that is designed to heal around the implant and promote acceptance in the patient's body. The one-piece dental implant has a shape that is optimized for automated robotic placement-site drilling and stress distribution. A method for designing a dental implant model for use with robotic site preparation of a dental implant insertion is also disclosed.
A61C 8/00 - Moyens destinés à être fixés à l'os de la mâchoire pour consolider les dents naturelles ou pour y assujettir des prothèses dentairesImplants dentairesOutils pour l'implantation
A material processing device that couples a spark discharge to a laser multicharged ion source to enhance the production of multicharged ions and increases ionization while simplifying structure. The processing device is capable of laser generation of multicharged ions for applications such as deposition and implantation. The ion beam of the device includes an electrostatic energy selector for controlling the energy of the ions used in processing. Some processing devices have the option to select ion charge over a wide range. The ability to select ions from a large spread of kinetic energy, and optionally with different charge states, offers a processing device with flexibility and applications in the areas of nanotechnology, microelectronics, and semiconductor processing.
H01J 47/00 - Tubes pour déterminer la présence, l'intensité, la densité ou l'énergie d'une radiation ou de particules
H01S 3/0977 - Procédés ou appareils pour l'excitation, p. ex. pompage par décharge dans le gaz d'un laser à gaz ayant des moyens d'ionisation auxiliaires
H01T 23/00 - Appareils pour la production d'ions destinés à être introduits dans des gaz à l'état libre, p. ex. dans l'atmosphère
70.
Multi-electrode electrical pulse delivery system for treatment of biological tissues
Systems and methods for treating or manipulating biological tissues are provided. In the systems and methods, a biological tissue is placed in contact with an array of electrodes. Electrical pulses are then applied between a bias voltage bus and a reference voltage bus of a distributor having switching elements associated with each of the electrodes. The switching elements provide a first contact position for coupling electrodes to bias voltage bus, a second contact position for coupling electrodes to the reference voltage bus, and a third contact position for isolating electrodes from the high and reference voltage buses. The switching elements are operated over various time intervals to provide the first contact position for first electrodes, a second contact position for second electrodes adjacent to the first electrodes, and a third contact position for a remainder of the electrodes adjacent to the first and second electrodes.
A61B 18/12 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage en faisant passer des courants à travers les tissus à chauffer, p. ex. des courants à haute fréquence
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
71.
ELECTROMANIPULATION OF CELLS AND OTHER BIOLOGICALTISSUES BY PULSED ELECTRIC FIELDS AT ELEVATED TEMPERATURES
Systems and methods for treatment of a biological tissues comprising target tissues and other tissues. The method includes elevating a temperature of the target tissues above a physiological temperature of the biological tissues to treatment temperature, and generating an electric field extending through at least a portion of the target tissues using a pre-defined sequence of short voltage pulses applied between at least two electrodes. In the method, the treatment temperature is maintained during the generating. Further, the pre-defined sequence is selected such that a magnitude of the electric field generated is sufficient to induce electromanipulation in the portion of the target tissues without substantially elevating of the temperature of the portion of the target tissues above the treatment temperature.
A61N 1/02 - ÉlectrothérapieCircuits à cet effet Parties constitutives
A61N 1/40 - Application de champs électriques par couplage inductif ou capacitif
A61B 18/08 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage à l'aide de sondes chauffées électriquement
A61B 18/12 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage en faisant passer des courants à travers les tissus à chauffer, p. ex. des courants à haute fréquence
Disclosed is a distortion invariant system, method and computer readable medium for detecting the presence of one or more predefined targets in an input image. The input image and a synthetic discriminant function (SDF) reference image are correlated in a shift phase-encoded fringe-adjusted joint transform correlation (SPFJTC) correlator yielding a correlation output. A peak-to-clutter ratio (PCR) is determined for the correlation output and compared to a threshold value. A predefined target is present in the input image when the PCR is greater than or equal to the threshold value.
Methods of fractionating proteins and lipids in algae are provided. The methods can extract peptides and amino acids from algae, can produce components used in food or fertilizer, and can improve algal biomass feed for biofuel production, as mom-limiting examples. One embodiment of a method as disclosed herein comprises providing a feed material of algae saturated with water to a reactor, bringing the water saturating the algae to a subcritical temperature within the reactor and separating a reactor effluent into solids and liquid.
C12P 21/04 - Peptides ou polypeptides cycliques ou pontés, p. ex. bacitracine
C12P 7/64 - GraissesHuilesCires de type esterAcides gras supérieurs, c.-à-d. ayant une chaîne continue d'au moins sept atomes de carbone liée à un groupe carboxyleHuiles ou graisses oxydées
C07K 14/405 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'algues
C11B 1/10 - Production des graisses ou huiles à partir de matières premières par extraction
C12N 1/12 - Algues unicellulairesLeurs milieux de culture
A plasma generator having a dielectric body; a first end wall and a second end wall attached or coupled to each end of the dielectric body to define a cavity within the dielectric body, and wherein the second end wall includes at least one discharge aperture formed therein; at least one gas inlet formed proximate the first end of the dielectric body; at least one anode located within the cavity of the dielectric body, wherein the at least one anode includes at least one anode aperture; at least one hollow discharge nozzle associated with each discharge aperture, and extending from the second end wall to a nozzle aperture, such that when a generated plasma is produced, the generated plasma flows through each discharge aperture, each associated discharge nozzles, and each associated nozzle aperture; and at least one cathode formed at least substantially around a portion of each discharge nozzle.
A61B 18/08 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage à l'aide de sondes chauffées électriquement
75.
PRODUCTION AND SEPARATION OF GLYCEROL-RELATED PRODUCTS USING VARIOUS FEED STOCKS
Disclosed are processes for producing glycerol-related products. One process for producing glycerol-related products comprises introducing glycerol and an alkylation reagent to a substantially oxygen free environment. Another process for producing glycerol-related products comprises introducing a glycerol and tetramethylammonium hydroxide to a substantially oxygen free environment.
C10G 3/00 - Production de mélanges liquides d'hydrocarbures à partir de matières organiques contenant de l'oxygène, p. ex. huiles, acides gras
C10L 1/02 - Combustibles carbonés liquides à base essentielle de composants formés uniquement de carbone, d'hydrogène et d'oxygène
C10L 1/08 - Combustibles carbonés liquides à base essentielle de mélanges d'hydrocarbures pour allumage par compression
C07C 67/03 - Préparation d'esters d'acides carboxyliques par réaction d'un groupe ester avec un groupe hydroxyle
C07C 67/08 - Préparation d'esters d'acides carboxyliques par réaction d'acides carboxyliques ou d'anhydrides symétriques avec le groupe hydroxyle ou O-métal de composés organiques
Use of an algal for biodiesel fuel selected for growing strain of production, the genus Desmodesmus wherein said strain was under high nutrient conditions and is characterized as having a determined fatty by acid nuclear methyl ester content of 2.6% magnetic resonance analysis, nitrogen content of 11.3% and a carbon content of 46.3%. Given the growth and elemental composition of this strain t the instant algal strain is of particular use as a biomass source for biofuel lipids and/or biodiesel fuel production.
Disclosed are processes for producing glycerol-related products. One process for producing glycerol-related products comprises introducing glycerol and an alkylation reagent to a substantially oxygen free environment. Another process for producing glycerol-related products comprises introducing a glycerol and tetramethylammonium hydroxide to a substantially oxygen free environment.
Disclosed herein is the use of terrestrial plant materials (e.g., leaves and bark) that contain biopolymer materials to produce hydrocarbon-rich crude oils that can be refined further into hydrocarbon-based biofuels, via the hydrous pyrolysis method, which involves heating to subcritical temperatures and pressures in an aqueous medium. One can also isolate the aliphatic biopolymers and utilize them as feedstocks for production of the hydrocarbon-rich crude via hydrous pyrolysis.
C07C 1/20 - Préparation d'hydrocarbures à partir d'un ou plusieurs composés, aucun d'eux n'étant un hydrocarbure à partir de composés organiques ne renfermant que des atomes d'oxygène en tant qu'hétéro-atomes
C07C 4/22 - Préparations d'hydrocarbures à partir d'hydrocarbures contenant un plus grand nombre d'atomes de carbone par dépolymérisation en monomère d'origine, p. ex. dépolymérisation du dicyclopentadiène pour obtenir du cyclopentadiène
79.
Low temperature plasma generator having an elongate discharge tube
A plasma generator for delivering a generated plasma to an area that is a distance from the area where the plasma is initially generated, including a dielectric tube portion extending from a gas inlet to a discharge aperture; an anode formed at least substantially around a portion of the discharge tube, wherein the anode is electrically coupled, via an electrical connection, to a power supply; a cathode formed at least substantially around a portion of the discharge tube, wherein the cathode is electrically coupled, via an electrical connection, to the power supply; and an elongate discharge tube attached or coupled to the discharge aperture such that when a generated plasma is produced, the generated plasma flows through the discharge tube.
Systems and methods for treatment of a heated exhaust gas including hydrocarbons are provided. A method includes providing a first gas including a gaseous mixture of vaporized diesel fuel and steam and treating the first gas using at least one corona discharge including a combination of streamers to transform the first gas into a second gas including volatile partially oxidized hydrocarbons (PO-HC) and hydrogen gas (H2), the combination of streamers including primarily surface streamers. The method also includes extracting at least a portion of vaporized diesel fuel and steam from the second gas to form a third gas and directing a combination of the third gas and the exhaust gas into a nitrogen oxides (NOx) reduction reactor.
Methods of enhancing membrane permeabilization in a cell are provided. A method includes disposing the cell between a first electrode and a second electrode and applying a plurality of electrical pulses between the first electrode and the second electrode. In the method, the plurality of electrical pulses include at least two trains of pulses separated by an interval greater than about 10s. Further, the amplitude of the electrical pulses is selected to be greater than about 0.2 kV/cm.
A nanoparticle translocation device includes a first reservoir having a first reservoir electrode, a second reservoir having a second reservoir electrode, and at least one nanopore providing fluid communication between the first and second reservoirs. The device also includes one or more inner electrode portions on an inner wall of the nanopore and one or more outer electrode portions disposed on an outer wall of the nanopore. The device further includes at least one DC voltage supply for selectively applying a DC voltage to each of the first reservoir electrode, the second reservoir electrode, and the outer electrode layer, where the inner electrode portions, the outer electrode portions, and the nanopore are in a substantially coaxial arrangement.
G01F 1/64 - Mesure du débit volumétrique ou du débit massique d'un fluide ou d'un matériau solide fluent, dans laquelle le fluide passe à travers un compteur par un écoulement continu en utilisant des effets électriques ou magnétiques en mesurant des courants électriques passant à travers l’écoulement de fluideMesure du débit volumétrique ou du débit massique d'un fluide ou d'un matériau solide fluent, dans laquelle le fluide passe à travers un compteur par un écoulement continu en utilisant des effets électriques ou magnétiques en mesurant le potentiel électrique produit par l’écoulement de fluide, p. ex. par effet électrochimique, effet de contact ou effet de frottement
83.
METHOD FOR SCALING PLASMA REACTORS FOR GAS TREATMENT AND DEVICES THEREFROM
Systems and methods for the treatment of a gas are provided. A method includes providing multiple discharge chambers defined by dielectric sections, where each of the discharge chambers comprises sets of electrodes for producing electric fields in the discharge chambers, where the dielectric sections and the sets of electrodes are arranged to define a volume that inhibits the formation of volume-streamers and the discharge chambers are configured to prevent pulsed electric fields generated in adjacent discharge chambers from substantially interacting. The method also includes directing the gas into the discharge chambers and treating the gas using a corona discharge in the discharge chambers produced by a pulsed electric field generated by each of the sets of the first and second electrodes in the discharge chambers, where the pulsed electric field is configured to produce the corona discharge to have surface-streamers and volume-streamers.
Systems and methods for treating or manipulating biological tissues are provided. In the systems and methods, a biological tissue is placed in contact with an array of electrodes. Electrical pulses are then applied between a bias voltage bus and a reference voltage bus of a distributor having switching elements associated with each of the electrodes. The switching elements provide a first contact position for coupling electrodes to bias voltage bus, a second contact position for coupling electrodes to the reference voltage bus, and a third contact position for isolating electrodes from the high and reference voltage buses. The switching elements are operated over various time intervals to provide the first contact position for first electrodes, a second contact position for second electrodes adjacent to the first electrodes, and a third contact position for a remainder of the electrodes adjacent to the first and second electrodes.
A61N 1/32 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents
A61B 18/12 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage en faisant passer des courants à travers les tissus à chauffer, p. ex. des courants à haute fréquence
A61N 1/18 - Application de courants électriques par électrodes de contact
A61N 1/30 - Appareils d'ionothérapie ou d'électrophorèse
85.
MULTI-ELECTRODE ELECTRICAL PULSE DELIVERY SYSTEM FOR TREATMENT OF BIOLOGICAL TISSUES
Systems and methods for treating or manipulating biological tissues are provided. In the systems and methods, a biological tissue is placed in contact with an array of electrodes. Electrical pulses are then applied between a bias voltage bus and a reference voltage bus of a distributor having switching elements associated with each of the electrodes. The switching elements provide a first contact position for coupling electrodes to bias voltage bus, a second contact position for coupling electrodes to the reference voltage bus, and a third contact position for isolating electrodes from the high and reference voltage buses. The switching elements are operated over various time intervals to provide the first contact position for first electrodes, a second contact position for second electrodes adjacent to the first electrodes, and a third contact position for a remainder of the electrodes adjacent to the first and second electrodes.
A61B 18/18 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par application de radiations électromagnétiques, p. ex. de micro-ondes
86.
System and methods of treatment using electromagnetic illumination
A method of inducing local cell death in patient tissue is provided. The method includes generating first and second radiation, conveying the radiation to a focusing element, and focusing the radiation on a target with the focusing element. A system for inducing local cell death in patient tissue is also provided. The system includes a power source for generating narrow-band and/or ultra-wideband radiation, and a focusing element for focusing the radiation on a target.
A61B 18/18 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par application de radiations électromagnétiques, p. ex. de micro-ondes
Disclosed herein is the production of hydrocarbon based fuel from micro-organisms and algae that comprise algaenan without requiring prior removal of water, as well as the production of hydrocarbon based fuel directly from the algaenan itself. Also disclosed herein are feed material for the processes disclosed herein comprising modified algae and algaenan that selectively produce hydrocarbon of desired chain lengths, along with the process of modifying the algae and algaenan. Also disclosed herein is the production of both hydrocarbon and organic fertilizer from algae without the need to remove the water from the algae prior to processing.
Disclosed herein is the production of hydrocarbon based fuel from micro-organisms and algae that comprise algaenan without requiring prior removal of water, as well as the production of hydrocarbon based fuel directly from the algaenan itself. Also disclosed herein are feed material for the processes disclosed herein comprising modified algae and algaenan that selectively produce hydrocarbon of desired chain lengths, along with the process of modifying the algae and algaenan. Also disclosed herein is the production of both hydrocarbon and organic fertilizer from algae without the need to remove the water from the algae prior to processing.
Described is a direct method for the fabrication of resorcinarene nanocapsules by photopolymerization of compounds of formula (I), such as resorcinarene tetraalkene tetrathiol (RTATT), in the absence of any template or preorganization. Further, by varying the polymerization media, a variety of other polymeric architectures like lattices, fibrous networks, and nanoparticles were obtained. The morphology and structure were characterized by transmission electron microscopy, energy dispersive spectroscopy, scanning electron microscopy, dynamic light scattering, infrared and nuclear magnetic resonance spectroscopy. These morphologically distinct resorcinarene polymeric architectures contain residual thiol and ene functional groups offering potential functionalization opportunities.
C08F 136/22 - Homopolymères de composés possédant un ou plusieurs radicaux aliphatiques non saturés, l'un au moins contenant plusieurs liaisons doubles carbone-carbone le radical contenant au moins trois doubles liaisons carbone-carbone
Systems and methods for cardiac rhythm management using a plurality of electrodes are provided, where at least one of the plurality of electrodes is in contact with a cardiac site. In the system and method, at least one sequence of electrical pulses is generated for electrically stimulating cardiac tissues using either of cathodal stimulation and anodal stimulation. Further, the at least one sequence of electrical pulses is applied to the cardiac tissue. In the system and method, the pulse widths in at least a portion of the at least one sequence of electrical pulses are configured to be less than about 1us and to have an amplitude and a frequency so that a threshold for the cathodal stimulation of the cardiac tissues and a threshold for the anodal stimulation of the cardiac tissues are substantially the same.
A method and device for treating a condition aggravated by the presence of amyloid fibrils is disclosed. The method includes applying a plurality of ultra-short pulses to target tissue comprising amyloid fibrils. The plurality of ultra-short pulses produce an electric field in the target tissue sufficient to change a molecular structure of the amyloid fibrils without causing the death, destruction, or serious injury of healthy cells surrounding the target tissue. For example, the plurality of ultra-short pulses can be sufficient to change the molecular structure of amyloid fibrils without causing apoptosis or necrosis of surrounding cells. The ultra-short pulses can be applied using an electrode device or a wideband antenna. The ultra-short pulses can have a duration ranging from 1 ps to 10 ns, an amplitude ranging from 100 V to 1MV, and can apply an electrical field to the target tissue ranging from 1kV/cm to 1MV/cm.
A61B 18/18 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par application de radiations électromagnétiques, p. ex. de micro-ondes
A61N 1/18 - Application de courants électriques par électrodes de contact
A method and device for treating a condition aggravated by the presence of amyloid fibrils is disclosed. The method includes applying a plurality of ultra-short pulses to target tissue comprising amyloid fibrils. The plurality of ultra-short pulses produce an electric field in the target tissue sufficient to change a molecular structure of the amyloid fibrils without causing the death, destruction, or serious injury of healthy cells surrounding the target tissue. For example, the plurality of ultra-short pulses can be sufficient to change the molecular structure of amyloid fibrils without causing apoptosis or necrosis of surrounding cells. The ultra-short pulses can be applied using an electrode device or a wideband antenna. The ultra-short pulses can have a duration ranging from 1 ps to 10 ns, an amplitude ranging from 100 V to 1 MV, and can apply an electrical field to the target tissue ranging from 1 kV/cm to 1 MV/cm.
A61N 1/20 - Application de courants électriques par électrodes de contact courants continus ininterrompus
A61N 1/32 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents
A61B 18/12 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage en faisant passer des courants à travers les tissus à chauffer, p. ex. des courants à haute fréquence
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
93.
Production of glycerol-related products from a high temperature reaction
Disclosed are processes for producing glycerol related products. One process comprises introducing a biomass and an alkylation reagent to a substantially oxygen free environment, hydrolyzing at a temperature at or above 200° C. one or more lipid glycerides in the biomass, methylating one or more fatty acids in the biomass with methyl groups from the alkylation reagent, wherein the hydrolyzing and methylating occur contemporaneously and separating resulting biodiesel and methylated glycerol-related products from a residue of the biomass by condensation.
A61K 31/20 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe carboxyle lié à une chaîne acyclique d'au moins sept atomes de carbone, p. ex. acides stéarique, palmitique ou arachidique
94.
Apparatus for generating electrical pulses and methods of using same
A method and apparatus are provided for delivering an agent into a cell through the application of nanosecond pulse electric fields (“nsPEF's”). The method includes circuitry for delivery of an agent into a cell via known methods followed by the application of nanosecond pulse electric fields to said cell in order to facilitate entry of the agent into the nucleus of the cell. In a preferred embodiment, the present invention is directed to a method of enhancing gene expression in a cell comprising the application of nanosecond pulse electric fields to said cell. An apparatus for generating long and short pulses according to the present invention is also provided. The apparatus includes a pulse generator capable of producing a first pulse having a long duration and low voltage amplitude and a second pulse having a short duration and high voltage amplitude.
Methods for a new, drug-free therapy for treating solid skin tumors through the application of nanosecond pulsed electric fields (“nsPEFs”) are provided. In one embodiment of the invention, the cells are melanoma cells, and the applied nsPEFs penetrate into the interior of tumor cells and cause tumor cell nuclei to rapidly shrink and tumor blood flow to stop. This new technique provides a highly localized targeting of tumor cells with only minor effects on overlying skin.
A method and device for aggregating algae in an aqueous solution is disclosed. The method can include providing an algae feed comprising a liquid and algae dispersed therein. The algae feed can be aggregated by applying a nanosecond pulsed electric field to the algae feed. The nanosecond pulsed electric field can include a plurality of electric pulses having a pulse duration ranging from 1 to 1,000 nanoseconds. The method can also include separating an aggregated algae stream from the algae feed and feeding the aggregated algae stream to a lipid extraction operation.
A method of treating a patient is described herein. The method can include the steps of identifying a target that contains biological tissue and directing one or more pulses of electromagnetic radiation at the target. The pulses of electromagnetic radiation can cause a temperature increase per unit of time in the biological tissue. Additionally, the temperature increase per unit of time can cause the change in the cell function in the biological tissue and can be within a range of approximately one degree Celsius per second to approximately one degree Celsius per microsecond.
A microhollow cathode discharge assembly capable of generating a low temperature, atmospheric pressure plasma micro jet is disclosed. The microhollow assembly has two electrodes: an anode and a cathode separated by a dielectric. A microhollow gas passage is disposed through the three layers. In some embodiments, the passage is tapered such that the area at the first electrode is larger than the area at the second electrode. When a potential is placed across the electrodes and a gas is directed through the gas passage, then a low temperature micro plasma jet can be created at atmospheric pressure or above.
Multiple walled nested coaxial nano structures, methods for making multiple walled nested coaxial nanostructures, and devices incorporating the coaxial nanostructures are disclosed. The coaxial nanostructures include an inner nanostructure, a first outer nanotube disposed around the inner nanostructure, and a first annular channel between the inner nanostructure and the first outer nanotube. The coaxial nanostructures have extremely high aspect ratios, ranging from about 5 to about 1,200, or about 300 to about 1200.
B82B 1/00 - Nanostructures formées par manipulation d’atomes ou de molécules, ou d’ensembles limités d’atomes ou de molécules un à un comme des unités individuelles
B82B 3/00 - Fabrication ou traitement des nanostructures par manipulation d’atomes ou de molécules, ou d’ensembles limités d’atomes ou de molécules un à un comme des unités individuelles
brevets
