Provided is a porous membrane containing a hydrophobic polymer and a water-insoluble hydrophilic polymer, wherein the pore diameter/fiber diameter of the outer surface of the porous membrane is 0.15-0.26, the major axis/minor axis of a pore circumscribed rectangle on the outer surface of the porous membrane is 1.00-1.60, the porous membrane has a dense layer, the abundance ratio of pores measuring 10 nm or less in the dense layer is 8.0% or less, and the thickness of the dense layer is 1-8 μm.
B01D 69/00 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétés; Procédés spécialement adaptés à leur fabrication
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétés; Procédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
The purpose of the invention is to provide a virus recovery method including reducing viability of cells in a culture solution and filtering, through a hollow fiber membrane, the culture solution containing a virus produced by the cells to recover the virus. The hollow fiber membrane has a gradient structure in which an average pore size becomes smaller from an upstream side to a downstream side in a membrane thickness direction.
The purpose of the present invention is to provide a viral clearance test method, including supplying a protein solution to a first channel provided with, upstream and downstream thereof, a protein purification unit and a virus removal filter, respectively, and pouring the protein solution into the protein purification unit at a first constant rate; supplying, at a second constant rate, a virus solution to a second channel connected between the protein purification unit and the virus removal filter in the first channel and mixing the purified protein solution with the virus solution in the first channel; pouring the mixture of the protein solution and the virus solution into the virus removal filter at a third constant rate; and measuring a virus contained in the permeate of the mixture which has passed through the virus removal filter.
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétés; Procédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
G01N 21/33 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p.ex. spectrométrie d'absorption atomique en utilisant la lumière ultraviolette
G01N 27/06 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance en recherchant la résistance d'un liquide
4.
EVALUATION METHOD OF FILTRATION CONDITION AND PRODUCTION METHOD OF CELL PRODUCT
A method for evaluating filtration condition(s), the method including: under conditions where cell growth is suppressed, feeding a culture fluid containing cells from a culture tank 11 containing the culture fluid to a porous membrane 12, returning the culture fluid, which has passed through the porous membrane 12 without being filtered, back to the culture tank 11 so as to circulate the culture fluid between the culture tank 11 and the porous membrane 12; and evaluating one or more filtration conditions in the porous membrane 12.
B01D 69/00 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétés; Procédés spécialement adaptés à leur fabrication
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétés; Procédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
C12P 1/00 - Préparation de composés ou de compositions, non prévue dans les groupes , utilisant des micro-organismes ou des enzymes; Procédés généraux de préparation de composés ou de compositions utilisant des micro-organismes ou des enzymes
C12P 21/02 - Préparation de peptides ou de protéines comportant une séquence connue de plusieurs amino-acides, p.ex. glutathion
C12Q 1/02 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des micro-organismes viables
C12Q 1/48 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir une transférase
5.
METHOD FOR PRODUCING CELL PRODUCT, METHOD FOR PURIFYING CELL PRODUCT, METHOD FOR SUPPRESSING DECREASE IN MEMBRANE PERMEABILITY OF CELL PRODUCT, SYSTEM FOR PRODUCING CELL PRODUCT, AND SYSTEM FOR PURIFYING CELL PRODUCT
Provided is a method for producing a cell product, the method comprising obtaining a cell product by filtering a cell culture medium through a porous membrane, wherein: the porous membrane has a liquid contact surface having at least one selected from the group consisting of an aperture ratio of 57.5% or less, a pore diameter having a variation coefficient of 0.5 or less, and a pore diameter/fiber diameter of 1.3 or less; the liquid contact surface has at least one selected from the group consisting of a structural anisotropy of 0.97-1.03 and a long diameter/short diameter of a hole of 1.8 or less; and the shear stress due to the flow of the culture medium on the liquid contact surface is 4.0 N/m2 or less.
B01D 69/00 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétés; Procédés spécialement adaptés à leur fabrication
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétés; Procédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
This method for purifying an antibody comprises preparing a solution containing an antibody, and filtering the solution using a porous membrane containing regenerated cellulose to purify the antibody. This method for purifying an antibody comprises preparing a solution containing an antibody, and filtering the solution using a porous membrane containing regenerated cellulose to purify the antibody, wherein: (A) Tr-Tm of the antibody in hydrophobic interaction chromatography is not less than 15 min; and/or (B) the k value of the antibody in hydrophobic interaction chromatography is not less than 19.
Provided is a chamber that can improve a fibrinogen recovery rate. This chamber 22 accommodates plasma when the plasma is being frozen and thawed to prepare a fibrinogen liquid from the plasma. The chamber 22 comprises a film section 51 that has an inner surface 60 contacting the plasma and an outer surface 61 contacting a heat source. A relief that has a surface roughness in which the arithmetic mean height is 0.7 μm to 1.7 μm is formed on the inner surface 60.
C07K 1/30 - Extraction; Séparation; Purification par précipitation
A61J 3/00 - Dispositifs ou procédés spécialement conçus pour donner à des produits pharmaceutiques une forme physique déterminée ou une forme propre à leur administration
The purpose of the invention is to provide a porous hollow-fiber membrane containing a regenerated cellulose and having an elastic limit pressure of 200 kPa or more.
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétés; Procédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
B01D 65/10 - Test de membranes ou d'appareils à membranes; Détection ou réparation de fuites
G01N 15/08 - Recherche de la perméabilité, du volume des pores ou de l'aire superficielle des matériaux poreux
9.
METHOD FOR SUPPLYING GAS TO PATIENT AND ARTIFICIAL VENTILATOR, CHEST COMPRESSION METHOD AND CHEST COMPRESSOR, ARTIFICIAL VENTILATION AND CHEST COMPRESSION METHOD AND SYSTEM THEREOF, AND BRAIN COOLING METHOD
Provided are a method for supplying a gas to a cardiac arrest patient, an artificial ventilator, etc. that have excellent practicality from comprehensive and realistic viewpoints while considering brain cooling rate, invasiveness, etc. To achieve the above, the artificial ventilator (100) of the present disclosure, which is to be used in combination with cardiac massage for a cardiac arrest patient, comprises: a detection means (110) for detecting whether or not the chest of the cardiac arrest patient is compressed by the cardiac massage; a control means (120) for controlling to supply a cooling gas to the airway of the cardiac arrest patient according to the timing at which the detection means (110) detects that the chest is not compressed; and a gas supply means (130) for inducing the cooling gas into the airway of the patient in response to the control by the control means (120).
The purpose of the present invention is to provide a method for evaluating the clogging of a filtration membrane with a protein-containing solution, including the steps of:
a) passing a protein-containing solution through a filtration membrane,
b) after the step a), obtaining a filtration membrane cross-section from the filtration membrane,
c) treating the protein-containing solution before the step a), the filtration membrane before the step b), or the filtration membrane cross-section after the step b) with at least one stain specific to a protein aggregate, and
d) confirming the presence of the protein aggregate in the filtration membrane cross-section.
B01D 65/10 - Test de membranes ou d'appareils à membranes; Détection ou réparation de fuites
C07K 1/34 - Extraction; Séparation; Purification par filtration, ultrafiltration ou osmose inverse
G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides
This hollow fiber membrane blood purifier includes hollow fiber membranes and a container in which the hollow fiber membranes are packed, wherein the hollow fiber membranes in the hollow fiber membrane blood purifier contain a fat-soluble substance, the proportion of flat fibers among all hollow fibers included in the hollow fiber membrane blood purifier is 5% or less, the flat fibers being such that the flatness calculated by formula (1): "short diameter of the outside diameter of the hollow fiber cross-section/long diameter of the outside diameter of the hollow fiber cross-section" is 0.5 or less, and the amount of the fat-soluble substance immobilized on the hollow fiber membrane being 1-500 mg/m2.
B01D 71/44 - Polymères obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, non prévus dans un seul des groupes
A hollow fiber membrane-type blood purifier that comprises a hollow fiber membrane and a container in which the hollow fiber membrane is filled, wherein: the hollow fiber membrane contains a fat-soluble substance; the acetic acid content per hollow fiber membrane area contained in the blood purifier is 1-40 mg/m2; the water permeability is 163 mL/Hr/mmHg/m2 or more; and the hollow fiber elongation is 55% or more.
Provided are a blood purification system, etc., to enable more achieve more efficient purification of blood. A blood purification system includes a line through which a liquid containing blood or filtrate flows, a blood purification device to purify the blood flowing through the line, a supply device to supply dialysate or replacement fluid to the line, a detector to detect blood information relating to the blood flowing through the line, a liquid control mechanism to control flow of liquid in the line based on control parameters, a parameter acquisition module to input the detected blood information into a learning model trained to output predetermined control parameters when predetermined blood information is input, and acquires control parameters outputted from the learning model, and a control module to control the liquid control mechanism based on the acquired control parameters.
Provided are a blood purification system, etc., to enable more achieve more efficient purification of blood. A blood purification system includes a line through which a liquid containing blood or filtrate flows, a plasma separation device to separate a plasma component from blood flowing through the line, a factor separating device to separate a factor component which is a pathogenic factor from the plasma component, a detector to detect blood information relating to blood flowing through the line, a liquid control mechanism to control flow of liquid in the line based on control parameters, a parameter acquisition module to input the detected blood information into a learning model trained to output predetermined control parameters when predetermined blood information is input, and acquire control parameters output from the learning model, and a control module to control the liquid control mechanism based on the acquired control parameters.
A61M 1/16 - Systèmes de dialyse; Reins artificiels; Oxygénateurs du sang avec membranes
G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
15.
CLOSED CIRCULATION SYSTEM TEST APPARATUS FOR BLOOD PURIFICATION DEVICE USING WHOLE BLOOD
A closed circulation system test apparatus independently sets the amount of a liquid such as a dialysate for a blood purification device, facilitates management of operations of multiple pumps, and is capable of evaluating performance for removing wastes in blood and lifespan performance of membranes. The closed circulation system test apparatus includes: a blood sending line for sending blood from the blood bag to the blood purification device via a blood pump; a blood returning line for sending blood exiting from the blood purification device to the blood bag via a resistance imparting means; a filtrate line for sending the filtrate exiting from a dialysate outlet of the blood purification device to the replacement fluid container via a filtrate pump; and a dialysate line for sending, via a dialysate pump, dialysate or replacement fluid from the replacement fluid container to a dialysate inlet of the blood purification device.
Provided is a method for evaluating the viral clearance capability of a virus removal medium, comprising the steps of: (a) adding a viral capsid-containing liquid to a solution to be purified; (b) contacting the virus removal medium with the solution to be purified that has been supplemented with the viral capsid-containing liquid to harvest a purified solution; and (c) quantifying a total viral capsid in the solution to be purified before the purification and a total viral capsid in the purified solution.
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
A blood treatment filter comprising a filter element, an inlet-side flexible container and an outlet-side flexible container, an inlet port, and a tubular outlet port, further comprises: an outlet-side frame sheet disposed between the filter element and the outlet-side flexible container; a first seal portion provided by sealing at least the filter element and the outlet-side frame sheet in a belt-shaped manner; and an annular second seal portion provided to surround the first seal portion, wherein on an outlet side of the filter element, a valley portion is formed at the first seal portion, the outlet port includes a protruding portion that protrudes to an inside of the container, and the protruding portion is provided with an opening at least a part of which overlaps with the first seal portion and which can communicate with a gap region formed by the valley portion.
A virus removal membrane includes cellulose, and a primary-side surface through which the protein-containing solution is to be applied and a secondary-side surface from which a permeate that has permeated the virus removal membrane is to be flowed, wherein a bubble point is 0.5 MPa or more and 1.0 MPa or less; and when a solution containing gold colloids having a diameter of 30 nm is applied through the primary-side surface to the virus removal membrane to allow the virus removal membrane to capture the gold colloids for measurement of brightness in a cross section of the virus removal membrane, a value obtained by dividing a standard deviation of a value of an area of a spectrum of variation in the brightness by an average of the value of the area of the spectrum of variation in the brightness is 0.01 or more and 0.30 or less.
B01D 65/10 - Test de membranes ou d'appareils à membranes; Détection ou réparation de fuites
B01D 67/00 - Procédés spécialement adaptés à la fabrication de membranes semi-perméables destinées aux procédés ou aux appareils de séparation
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétés; Procédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
D01D 5/24 - Formation des filaments, fils ou similaires à structure creuse; Ensembles de filage à cet effet
D01F 2/04 - Filaments, ou similaires, artificiels, à un seul composant, formés de cellulose ou de dérivés de la cellulose; Leur fabrication obtenus à partir de solutions de cellulose dans des acides, des bases ou des sels obtenus à partir de solutions cupro-ammoniacale
A virus recovery method that comprises lowering the survival rate of cells in a liquid culture medium and filtering the liquid culture medium containing a virus produced by the cells using a hollow fiber membrane to recover the virus, wherein the hollow fiber membrane has an inclined structure in which the average pore size decreases from the primary side to the secondary side in the membrane thickness direction.
B01D 61/00 - Procédés de séparation utilisant des membranes semi-perméables, p.ex. dialyse, osmose ou ultrafiltration; Appareils, accessoires ou opérations auxiliaires, spécialement adaptés à cet effet
C12N 1/00 - Micro-organismes, p.ex. protozoaires; Compositions les contenant; Procédés de culture ou de conservation de micro-organismes, ou de compositions les contenant; Procédés de préparation ou d'isolement d'une composition contenant un micro-organisme; Leurs milieux de culture
C12N 1/02 - Séparation des micro-organismes de leurs milieux de culture
20.
Phosphate adsorbing agent for blood processing, blood processing system and blood processing method
The present invention relates to a phosphate adsorbing agent for blood processing comprising a porous formed article comprising an organic polymer resin and an inorganic ion adsorbent and having the most frequent pore size of 0.08 to 0.70 μm measured with a mercury porosimeter. The present invention also relates to a blood processing system and a blood processing method involving the phosphate adsorbing agent for blood processing.
B01J 20/02 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation contenant une substance inorganique
B01J 20/06 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant des oxydes ou des hydroxydes des métaux non prévus dans le groupe
B01J 20/08 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant des oxydes ou des hydroxydes des métaux non prévus dans le groupe contenant de la bauxite
B01J 20/10 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant de la silice ou un silicate
B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques
21.
BLOOD PROCESSING FILTER, METHOD FOR PRODUCING SAME, AND METHOD FOR REMOVING LEUKOCYTE
An object is to provide a blood processing filter favorable in both of the effectiveness (leukocyte removing performance) and the safety (reduction in the amount of elutable substances). The object can be achieved by a blood processing filter comprising a filtration medium including a polyester fiber, wherein a surface area of the filtration medium is 6.0 m2 or more, and a maximum absorbance of an aqueous extract of the blood processing filter in the range from 240 to 245 nm is 0.03 or less.
A viral clearance test method that comprises: supplying a protein solution into a first channel 10, in which a protein purification part 11 is provided upstream and a virus removal filter 12 is provided downstream, and flowing the protein solution at a first constant speed to the protein purification part 11; supplying a virus solution at a second constant speed to a second channel 20, which is connected between the protein purification part 11 and the virus removal filter 12 of the first channel, and mixing the purified protein solution with the virus solution in the first channel 10; flowing the solution mixture of the protein solution with the virus solution at a third constant speed through the virus removal filter 12; and measuring the virus contained in the permeate of the solution mixture having passed through the virus removal filter 12.
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
B01D 65/10 - Test de membranes ou d'appareils à membranes; Détection ou réparation de fuites
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétés; Procédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
A method for producing a polyamide medium for purifying a protein-containing solution, comprising: a step of treating a polyamide medium before a treatment with an acidic or alkaline aqueous solution, with an acidic or alkaline aqueous solution.
C07K 1/34 - Extraction; Séparation; Purification par filtration, ultrafiltration ou osmose inverse
C07K 16/40 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre des enzymes
B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques
24.
PACKING MATERIAL, PACKED BODY, MODULE ASSEMBLY, AND MODULE PACKING METHOD
Provided is a packing material by which breakage of a header part of a module and breakage of a packaging bag of the module can be suppressed. This packing material 1 is for packing, into a box B, modules M each having a cylindrical body part M1 and header parts M2 attached to both longitudinal ends of the body part M1. The packing material: comprises body part support surfaces 10 for at least partially supporting lower surfaces M11 of the body parts M1 of the modules M which are in a recumbent state, body part support walls 20 for supporting the modules M so as to sandwich both side surfaces M12 of the body parts M1 thereof, and top surface support walls 30 for supporting top surfaces M22 of the both header parts M2 of the modules M; and is configured such that when the modules M are supported by the body part support surfaces 10, the body part support walls 20, and the top surface support walls 30, the packing material 1 is prevented from coming into contact with side surfaces M21 of the header parts M2 of the modules.
B65D 77/26 - Eléments ou dispositifs pour placer ou protéger les objets
B65D 85/20 - Réceptacles, éléments d'emballage ou paquets spécialement adaptés à des objets ou à des matériaux particuliers pour objets incompressibles ou rigides en forme de baguette ou tubulaires
B65D 81/05 - Réceptacles, éléments d'emballage ou paquets pour contenus présentant des problèmes particuliers de stockage ou de transport ou adaptés pour servir à d'autres fins que l'emballage après avoir été vidés de leur contenu spécialement adaptés pour protéger leur contenu des dommages mécaniques maintenant le contenu en position éloignée des parois de l'emballage ou des autres pièces du contenu
25.
POROUS HOLLOW-FIBER MEMBRANE AND METHOD FOR TESTING INTEGRITY
The purpose of the invention is to provide a porous hollow-fiber membrane containing a regenerated cellulose and having an elastic limit pressure of 200 kPa or more.
B01D 65/10 - Test de membranes ou d'appareils à membranes; Détection ou réparation de fuites
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétés; Procédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
D01F 2/04 - Filaments, ou similaires, artificiels, à un seul composant, formés de cellulose ou de dérivés de la cellulose; Leur fabrication obtenus à partir de solutions de cellulose dans des acides, des bases ou des sels obtenus à partir de solutions cupro-ammoniacale
26.
POROUS HOLLOW-FIBER MEMBRANE AND METHOD FOR TESTING INTEGRITY
The present invention is a porous hollow-fiber membrane that includes recycled cellulose, wherein the elastic limit pressure of the porous hollow fiber membrane is 200 kPa or more.
B01D 65/10 - Test de membranes ou d'appareils à membranes; Détection ou réparation de fuites
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétés; Procédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
G01M 3/26 - Examen de l'étanchéité des structures ou ouvrages vis-à-vis d'un fluide par utilisation d'un fluide ou en faisant le vide par mesure du taux de perte ou de gain d'un fluide, p.ex. avec des dispositifs réagissant à la pression, avec des indicateurs de débit
D01F 2/00 - Filaments, ou similaires, artificiels, à un seul composant, formés de cellulose ou de dérivés de la cellulose; Leur fabrication
D01F 2/04 - Filaments, ou similaires, artificiels, à un seul composant, formés de cellulose ou de dérivés de la cellulose; Leur fabrication obtenus à partir de solutions de cellulose dans des acides, des bases ou des sels obtenus à partir de solutions cupro-ammoniacale
A method for purifying a protein-containing solution comprising a protein of interest, the method comprising the steps of:
A method for purifying a protein-containing solution comprising a protein of interest, the method comprising the steps of:
(a1) contacting the protein-containing solution with a porous medium comprising polyketone; and
A method for purifying a protein-containing solution comprising a protein of interest, the method comprising the steps of:
(a1) contacting the protein-containing solution with a porous medium comprising polyketone; and
(a2) passing the protein-containing solution contacted with the porous medium comprising polyketone through a virus removal membrane.
B01D 71/44 - Polymères obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, non prévus dans un seul des groupes
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétés; Procédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
Provided is a blood purifier which has a porous molded body with good phosphorus adsorption, which has good cytokine adsorption performance, no hemolysis, and can be used safely. The blood purifier has a porous molded body having a low-melting-point moisture content per gram of dry weight of 0.12 g or more and 1.35 g or less. After three and six months from sealing of a saline solution for injection into the blood purifier, the number of microparticles greater than or equal to 10 μm is 25 or less and the number of microparticles greater than or equal to 25 μm is three or less in 1 mL of the saline solution for injection.
A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p.ex. adaptation de la température, irradiation
A61M 1/14 - Systèmes de dialyse; Reins artificiels; Oxygénateurs du sang
B01J 20/08 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant des oxydes ou des hydroxydes des métaux non prévus dans le groupe contenant de la bauxite
B01J 20/10 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant de la silice ou un silicate
The problem is to provide a porous membrane with a reduced phenomenon in which membranes firmly adhere to one another during production of the porous membrane (membrane adhesion). The problem is solved by a porous membrane comprising a hydrophobic polymer and a hydrophilic polymer, wherein an average value T of ratios of the number of counts of ions derived from the hydrophilic polymer to the number of counts of ions derived from the hydrophobic polymer is 1.0 or more when a surface of the porous membrane is measured by time-of-flight secondary ion mass spectrometry (TOF-SIMS).
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétés; Procédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
B01D 71/40 - Polymères d'acides non saturés ou de leurs dérivés, p.ex. sels, amides, imides, nitriles, anhydrides, esters
D01F 6/76 - Filaments, ou similaires, faits par l’homme, à un seul composant, formés de polymères synthétiques; Leur fabrication à partir de produits d'homopolycondensation à partir d'autres produits de polycondensation
D06M 15/263 - Composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone d'acides carboxyliques non saturés; Leurs sels ou esters
30.
Strong cation exchange chromatographic matrix and method for using same
A cation exchange chromatographic matrix comprising a base material, and a copolymer with one monomer unit having at least a sulfonic acid group, the copolymer being immobilized on the base material, wherein: the copolymer forms substantially no cross-linked structure, and the copolymer comprises neither acrylamide nor an acrylamide derivative as a monomer unit, or comprises acrylamide or an acrylamide derivative as a monomer unit in a range which has no substantial influence; the ratio of the mass of the copolymer to the mass of the base material is 5% or more and 200% or less; and the density of the sulfonic acid group is higher than 30 mmol/L and 200 mmol/L or lower.
B01D 15/18 - Adsorption sélective, p.ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives aux différents types d'écoulement
B01D 15/36 - Adsorption sélective, p.ex. chromatographie caractérisée par le mécanisme de séparation impliquant une interaction ionique, p.ex. échange d'ions, paire d'ions, suppression d'ions ou exclusion d'ions
B01D 15/38 - Adsorption sélective, p.ex. chromatographie caractérisée par le mécanisme de séparation impliquant une interaction spécifique non couverte par un ou plusieurs des groupes , p.ex. chromatographie d'affinité, chromatographie d'échange par ligand ou chromatographie chirale
B01J 39/05 - Procédés utilisant des échangeurs organiques sous forme fortement acide
B01J 39/20 - Composés macromoléculaires obtenus par des réactions ne faisant intervenir que des liaisons carbone-carbone non saturées
B01J 39/26 - Echange de cations; Utilisation d'une substance comme échangeur de cations; Traitement d'une substance en vue d'améliorer ses propriétés d'échange de cations Échangeurs de cations pour procédés chromatographiques
C07K 1/22 - Chromatographie d'affinité ou techniques analogues basées sur des procédés d'absorption sélective
C07K 16/00 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux
C08F 255/02 - Composés macromoléculaires obtenus par polymérisation de monomères sur des polymères d'hydrocarbures tels que définis dans le groupe sur des polymères d'oléfines contenant deux ou trois atomes de carbone
B01J 39/07 - Procédés utilisant des échangeurs organiques sous forme faiblement acide
B01J 47/12 - Procédés d'échange d'ions en général; Appareillage à cet effet caractérisés par l'emploi d'une substance échangeur d'ions sous forme de rubans, de filaments, de fibres ou de feuilles, p.ex. sous forme de membranes
G01N 30/88 - Systèmes intégrés d'analyse, spécialement adaptés à cet effet, non couverts par un seul des groupes
B01J 47/127 - Procédés d'échange d'ions en général; Appareillage à cet effet caractérisés par l'emploi d'une substance échangeur d'ions sous forme de rubans, de filaments, de fibres ou de feuilles, p.ex. sous forme de membranes sous forme de filaments ou de fibres
A blood purifier includes a porous molded body; exhibits an excellent blood compatibility wherein platelet adherence is inhibited and exhibits a good cytokine adsorption capacity and a low pressure loss before and after blood treatment; and can be safely used. A blood purifier includes a main vessel and a porous molded body housed in the main vessel. The porous molded body contains a hydrophobic polymer and a hydrophilic polymer. The amount of low-melting-point water per 1 g of dry weight of the porous molded body is 0.12 g to 2.00 g. The contact change ratio for the porous molded body is 0% to 0.2%. The ratio L/D is 1.00 to 2.30 where, for the region taken up by the porous molded body in the main vessel, L is the length in the flow direction and D is the circle-equivalent diameter of the cross section in the direction perpendicular to the flow direction.
B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques
B01J 20/06 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant des oxydes ou des hydroxydes des métaux non prévus dans le groupe
B01J 20/285 - Absorbants ou adsorbants poreux à base de polymères
Provided is a blood purifier which includes a porous formed body and which has excellent blood compatibility, in which platelets are unlikely to adhere, has good cytokine adsorption capacity, and low pressure loss before and after treating blood, and can be safely used. Disclosed is a blood purifier having a body container, and a porous formed body accommodated in the body container. The porous formed body contains a hydrophobic polymer and a hydrophilic polymer, the low-melting-point water content per 1 g of dry weight of the porous formed body is 0.12-2.00 g, the rate of contact change of the porous formed body is 0-0.2%, and the adhering amount of platelets per 1 mL of blood is 0.400 billion/mL or less when brining the blood into contact with the porous formed body.
An extracorporeal blood circulation device is provided with: a blood component adjuster; a blood purification device; a pipe system provided with a pump for supplying blood from a blood collecting part to the blood component adjuster, a valve for supplying a physiological saline solution, and a pressure gauge for sensing a pressure loss; a bypass pipe system for bypassing the blood component adjuster and supplying blood to the blood purification device; a pipe system for connecting the blood component adjuster and the blood purification device, the pipe system being provided with a pressure gauge for sensing a pressure loss; a pipe system provided with a valve for returning blood from the blood purification device to a reinfusion part and recovering the physiological saline solution, and a pressure gauge for sensing a pressure loss; and a control unit for switching to the bypass pipe system and switching to a reinfusion mode.
A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p.ex. adaptation de la température, irradiation
A61M 1/16 - Systèmes de dialyse; Reins artificiels; Oxygénateurs du sang avec membranes
B01J 20/02 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation contenant une substance inorganique
B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques
Provided is a method for evaluating clogging of a filtration membrane for a protein-containing solution, the method comprises the following: a) a step for passing the protein-containing solution through the filtration membrane; b) a step for acquiring a filtration membrane cross-section from the filtration membrane after step a); c) a step for treating, with at least one type of stain specific to a protein aggregate, the protein-containing solution before step a), the filtration membrane before step b), or the filtration membrane cross-section after step b); and d) a step for confirming the presence of the protein aggregate in the filtration membrane cross-section.
C07K 1/34 - Extraction; Séparation; Purification par filtration, ultrafiltration ou osmose inverse
C12Q 1/28 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir une oxydoréductase une peroxydase
C12Q 1/42 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir une hydrolase une phosphatase
G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
Process filter used for the removal of viruses, microbes and
the like, in the manufacturing process of plasma
fractionation and biopharmaceutical products. Process filter used for the removal of viruses, microbes and
the like in the apparatus and instrument for the laboratory. Process filter used for the removal of viruses, microbes and
the like in the medical apparatus and instrument.
Provided is a blood purification device including a porous molded body that has a high phosphorus adsorption capacity and that can be used safely. A blood purification device includes a porous molded body containing an inorganic ion-adsorbing material and is characterized by the following: said blood purification device satisfies the relationship B=−0.02 A+2.175±0.185 (74≤A≤94) when the moisture content of the porous molded body is denoted by A and the bulk density is denoted by B; and the number of fine particles having a size of 10 μm or more is 25 or less and the number of fine particles having a size of 25 μm or more is 3 or less in 1 mL of a physiological saline solution for injection both three months and six months after said physiological saline solution for injection is sealed in the blood purification device.
A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p.ex. adaptation de la température, irradiation
B01J 20/06 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant des oxydes ou des hydroxydes des métaux non prévus dans le groupe
B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques
B01J 20/30 - Procédés de préparation, de régénération ou de réactivation
Provided are a blood purification system and the like, capable of more appropriately carrying out blood purification. The blood purification system comprises: a line through which a liquid including blood or filtrate flows; a plasma separation device that separates a plasma component from the blood flowing through the line; a factor separation device that separates, from the plasma component, a factor component causing a disease; a detecting unit that detects blood information relating to the blood flowing through the line; a liquid controlling mechanism that controls the flow of the liquid within the line on the basis of a controlling parameter; a parameter acquiring unit that inputs, into a learning model having been trained to output a predetermined controlling parameter when a predetermined piece of blood information is input thereinto, the detected blood information and acquires the controlling parameter output from the learning model; and a controlling unit that controls the liquid controlling mechanism on the basis of the acquired controlling parameter.
Provided is a closed circulation system test apparatus that independently sets the amount of a liquid such as a dialysate for a blood purification device, facilitates management of operations of multiple pumps, and is capable of evaluating, under the condition where the water removal amount is increased, performance for removing wastes in blood and lifespan performance of membranes. The closed circulation system test apparatus according to the present invention performs a performance evaluation test on a blood purification device within a closed circuit not in contact with the atmosphere, with the blood purification device, a blood bag, and a replacement fluid container being set in the closed circulation system test apparatus. The closed circulation system test apparatus is characterized by comprising: a blood sending line for sending blood from the blood bag to the blood purification device via a blood pump; a blood returning line for sending blood exiting from the blood purification device to the blood bag via a resistance imparting means; a filtrate line for sending the filtrate exiting from a dialysate outlet of the blood purification device to the replacement fluid container via a filtrate pump; and a dialysate line for sending, via a dialysate pump, dialysate or replacement fluid from the replacement fluid container to a dialysate inlet of the blood purification device and/or to the blood returning line.
Provided are a blood purification system and the like, capable of more appropriately carrying out blood purification. The blood purification system comprises: a line through which a liquid including blood or filtrate flows; a blood purification device that purifies the blood flowing through the line; a feeder that feeds a dialysate or replacement fluid to the line; a detecting unit that detects blood information relating to the blood flowing through the line; a liquid controlling mechanism that controls the flow of the liquid within the line on the basis of a controlling parameter; a parameter acquiring unit that inputs, into a learning model having been trained to output a predetermined controlling parameter when a predetermined piece of blood information is input thereinto, the detected blood information and acquires the controlling parameter output from the learning model; and a controlling unit that controls the liquid controlling mechanism on the basis of the acquired controlling parameter.
The present invention addresses the problem of providing a blood treatment filter having an excellent filtration rate. The problem can be solved by the blood treatment filter comprising: a container having an inlet part and an outlet part of blood; and a filter medium disposed between the inlet part and the outlet part in the container, wherein the filter medium comprises a filter element, the average thickness of the filter medium is 7-12 mm, and the standard deviation in thickness of the filter medium is 0.30-0.80 mm.
A method for evaluating the viral clearance performance of a virus-removing medium, said method involving: (a) a step for adding a virus capsid-containing liquid to a solution to be purified; (b) a step for recovering a purified solution by contacting the solution to be purified to which the virus capsid-containing liquid has been added to the virus-removing medium; and (c) a step for quantifying the total virus capsid amount in the solution to be purified before said purification occurs and the the total virus capsid amount in the purified solution.
C12Q 1/34 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir une hydrolase
C12Q 1/686 - Réaction en chaine par polymérase [PCR]
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
G01N 33/569 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour micro-organismes, p.ex. protozoaires, bactéries, virus
09 - Appareils et instruments scientifiques et électriques
Produits et services
(1) Measuring and testing machines namely apparatus for measuring filter membrane quality for removal of virus from biotherapeutic drug products, apparatus for testing virus removal through the hollow fibers; detectors namely automatic indicators of filter membrane quality; leak detectors for filters namely leak detection indicator of filter membrane quality.
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
(1) Manufacturing filter for chemical processing, namely, process filters used for the removal of viruses and microbes in the manufacturing process of plasma fractionation and biopharmaceutical products.
(2) Laboratory filters, namely, process filters used for the removal of viruses and microbes in laboratory instruments for use in biopharmaceutical products.
(3) Medical process filters used for the removal of viruses and microbes in medical instruments, for medical purposes.
09 - Appareils et instruments scientifiques et électriques
Produits et services
Measuring or testing machines and instruments, namely, machines for testing filters used for removing viruses from drug products; detectors for detecting defects in the fibers of filters used for removing viruses from drug products; leak detectors for filters
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
Filtering machines for chemical processing, namely, process filter used for the removal of viruses, microbes and the like, in the manufacturing process of plasma fractionation and biopharmaceutical products Laboratory filters, namely, process filter used for the removal of viruses, microbes and the like in the laboratory apparatus and instrument Medical device in the nature of process filter used for the removal of viruses, microbes and the like in the medical apparatus and instrument, for medical purposes
Provided are beads for blood processing having porous beads and a polymer carried on the surface of the porous beads, wherein: the porous beads are configured from at least one resin selected from the group consisting of acrylic resins, styrene resins, and cellulose resins; and the polymer includes a specific monomer defined in the description as a monomer unit.
B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques
A porous membrane containing a hydrophobic polymer and a water-insoluble hydrophilic polymer, the porous membrane having a dense layer in the downstream portion of filtration in the membrane, having a gradient asymmetric structure in which the average pore diameter of fine pores increases from the downstream portion of filtration toward the upstream portion of filtration, and having a gradient index of the average pore diameter from the dense layer to the coarse layer of 0.5 to 12.0.
B01D 69/00 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétés; Procédés spécialement adaptés à leur fabrication
B01D 67/00 - Procédés spécialement adaptés à la fabrication de membranes semi-perméables destinées aux procédés ou aux appareils de séparation
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétés; Procédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
Provided are beads for blood processing having porous beads and a polymer carried on the surface of the porous beads, wherein: the porous beads are configured from at least one resin selected from the group consisting of acrylic resins, styrene resins, and cellulose resins; and the polymer includes a specific monomer defined in the description as a monomer unit.
B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques
50.
BLOOD TREATMENT FILTER AND METHOD FOR MANUFACTURING SAME, AND LEUKOCYTE REMOVAL METHOD
The present invention addresses the problem of providing a blood treatment filter having excellent effectiveness (leukocyte removal performance) and safety (reduction in amount of an eluted material). The problem can be solved by a blood treatment filter which comprises a filtering material comprising polyester fibers, wherein the surface area of the filtering material is 6.0 m2 or more and the maximum absorbance of a water extraction solution of the blood treatment filter in the range from 240 to 245 nm is 0.03 or less.
The present invention addresses the problem of providing a blood processing filter excellent in white blood cell removal rate and filtration time (filtration speed). The problem can be solved by the following blood processing filter. A blood processing filter that includes a container having an inlet part and an outlet part for blood, and a filter medium positioned between the inlet part and the outlet part in the container. The filter medium includes a filter layer. The filter layer includes a non-woven fabric. Fibers of the non-woven fabric have an orientation degree X in an X-axis planar direction of the filter layer and an orientation degree Y in a Y-axis planar direction orthogonal to the X-axis planar direction, the maximum value of the ratio of the orientation degree X to the orientation degree Y (orientation degree X/orientation degree Y) being 1.2 or more.
B01D 39/16 - Autres substances filtrantes autoportantes en substance organique, p.ex. fibres synthétiques
B01D 29/01 - Filtres à éléments filtrants stationnaires pendant la filtration, p.ex. filtres à aspiration ou à pression, non couverts par les groupes ; Leurs éléments filtrants avec des éléments filtrants plats
A61M 5/165 - Accessoires de filtrage, p.ex. filtres pour le sang, pour les liquides de perfusion
A61M 1/02 - Appareils pour transfusion sanguine d'un corps à un autre
A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p.ex. adaptation de la température, irradiation
52.
Blood purification device and method for producing same
A blood purification device includes a porous molded body containing an inorganic ion-adsorbing material and is characterized by the following: the concentrations of Mg, Al, Ti, V, Cr, Mn, Fe, Ni, Cu, Zn, Ga, Rb, Sr, Y, Zr, Mo, Ru, Ag, Cd, Sn, Cs, La, Pr, Sm, Gd, Tb, Ta, Au, Tl, Co, In, and Bi are each 0.1 ppb or less and the concentrations of Ba, Nd, Pb, And Ce are each 1 ppb or less in a physiological saline solution for injection both three months and six months after said physiological saline solution for injection is sealed in the blood purification device; and the number of fine particles having a size of 10 μm or more is 25 or less and the number of fine particles having a size of 25 μm or more is 3 or less in 1 mL of the physiological saline solution for injection.
The present invention addresses the problem of providing a blood treatment filter that is excellent in all of leukocyte removal performance, filtration time (filtration speed) and blood recovery. This problem can be solved by the blood treatment filter mentioned below. The blood treatment filter comprises a flexible container having an inlet port of blood and an outlet port of blood, a filter medium disposed between the inlet port and the outlet port in the flexible container, and a flow path-securing member disposed between the filter medium and the outlet port in the flexible container, wherein: the filter medium comprises a filter layer X1 containing a filter-forming unit A1 and a filter layer Y containing a filter-forming unit B; the filter layer X1 is disposed between the filter layer Y and the flow path-securing member; the aeration resistance per thickness of the filter-forming unit A1 is 5.0 Pa•s/m2or more and less than 9.0 Pa•s/m2; the aeration resistance per thickness of the filter-forming unit B is 9.0 Pa•s/m2 or more; the aeration resistance of the filter layer X1 is 4.0 kPa•s/m or more and not more than 20.0•kPa s/m; and the aeration resistance of the filter medium is 55.0 kPa•s/m or more and less than 75.0 kPa•s/m.
This concentration calculation device comprises: a radiation unit that irradiates dialysis drainage with excitation light; a detection unit that detects fluorescence generated from the dialysis drainage; a classification unit that classifies the spectrum of fluorescence detected by the detection unit into one from among a predetermined plurality of groups; and a concentration detection unit that calculates the concentration of albumin included in the dialysis discharge on the basis of a calibration model that corresponds to the group of the fluorescence spectrum classified by the classification unit, from among a plurality of calibration models provided in advance in correspondence with each of the plurality of groups, and also on the basis of the fluorescence intensity of a plurality of wavelengths in a predetermined wavelength range for the spectrum of the fluorescence detected by the detection unit.
A blood treatment filter comprising a filter element, an inlet-side flexible container and an outlet-side flexible container, an inlet port, and a tubular outlet port, further comprises: an outlet-side frame sheet disposed between the filter element and the outlet-side flexible container; a first seal portion provided by sealing at least the filter element and the outlet-side frame sheet in a belt-shaped manner; and an annular second seal portion provided to surround the first seal portion, wherein on an outlet side of the filter element, a valley portion is formed at the first seal portion, the outlet port includes a protruding portion that protrudes to an inside of the container, and the protruding portion is provided with an opening at least a part of which overlaps with the first seal portion and which can communicate with a gap region formed by the valley portion.
This method is for producing a polyamide medium for purifying a protein-containing solution and comprises a step for treating, with an acidic or alkaline aqueous solution, a polyamide medium yet to be treated with said acidic or alkaline aqueous solution.
Provided is a blood purifier that comprises a porous molded body; that exhibits an excellent blood compatibility wherein platelet adherence is inhibited and exhibits a good cytokine adsorption capacity and a low pressure loss before and after blood treatment; and that can be safely used. Disclosed is a blood purifier that comprises a main vessel and a porous molded body housed in the main vessel. The porous molded body contains a hydrophobic polymer and a hydrophilic polymer. The amount of low-melting-point water per 1 g of dry weight of the porous molded body is 0.12 g to 2.00 g. The contact change ratio for the porous molded body is 0% to 0.2%. The ratio L/D is 1.00 to 2.30 where, for the region taken up by the porous molded body in the main vessel, L is the length in the flow direction and D is the circle-equivalent diameter of the cross section in the direction perpendicular to the flow direction. The circle-equivalent diameter D is calculated based on formula (A): D = 2√(V/L/3.14) (A). In formula (A), V is the apparent volume of the region taken up by the porous molded body in the main vessel. In addition, when an aqueous polyvinylpyrrolidone solution with a viscosity adjusted to 3.75 mPa·s to 3.85 mPa·s is flowed through the blood purifier at a flow-through rate of 400 mL/minute, the pressure loss of the blood purifier before blood treatment is less than 13 kPa and the pressure loss of the blood purifier after blood treatment is less than 13 kPa.
B01J 20/06 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant des oxydes ou des hydroxydes des métaux non prévus dans le groupe
B01J 20/08 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant des oxydes ou des hydroxydes des métaux non prévus dans le groupe contenant de la bauxite
B01J 20/10 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant de la silice ou un silicate
B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques
B01J 20/30 - Procédés de préparation, de régénération ou de réactivation
A61M 1/02 - Appareils pour transfusion sanguine d'un corps à un autre
A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p.ex. adaptation de la température, irradiation
The present invention addresses the problem of providing a porous membrane in which the phenomenon of membranes fusing to each other (membrane sticking) during manufacture of the porous membrane is reduced. The problem can be solved by a porous membrane containing a hydrophobic polymer and a hydrophilic polymer, wherein the average value T of the ratio of the hydrophilic polymer-derived ion count relative to the hydrophobic polymer-derived ion count, when the surface of the porous membrane is measured by Time-of-Flight Secondary Ion Mass Spectrometry (TOF-SIMS), is 1.0 = T.
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétés; Procédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
D01F 6/76 - Filaments, ou similaires, faits par l’homme, à un seul composant, formés de polymères synthétiques; Leur fabrication à partir de produits d'homopolycondensation à partir d'autres produits de polycondensation
D06M 15/263 - Composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone d'acides carboxyliques non saturés; Leurs sels ou esters
The present invention addresses the problem of providing a porous membrane in which the phenomenon of membranes fusing to each other (membrane sticking) during manufacture of the porous membrane is reduced. The problem can be solved by a porous membrane containing a hydrophobic polymer and a hydrophilic polymer, wherein the average value T of the ratio of the hydrophilic polymer-derived ion count relative to the hydrophobic polymer-derived ion count, when the surface of the porous membrane is measured by Time-of-Flight Secondary Ion Mass Spectrometry (TOF-SIMS), is 1.0 ≤ T.
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétés; Procédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
D06M 101/30 - Polymères synthétiques consistant en composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone
D01F 6/76 - Filaments, ou similaires, faits par l’homme, à un seul composant, formés de polymères synthétiques; Leur fabrication à partir de produits d'homopolycondensation à partir d'autres produits de polycondensation
D06M 15/263 - Composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone d'acides carboxyliques non saturés; Leurs sels ou esters
A method for purifying a protein-containing solution that contains a target protein, said method comprising: (α1) a step for contacting the protein-containing solution with a porous medium containing a polyketone; and (α2) a step for passing the protein-containing solution, which has been contacted with the porous medium containing the polyketone, through a virus removal film.
B01D 65/08 - Prévention de l'encrassement de la membrane ou de la polarisation par concentration
B01D 69/00 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétés; Procédés spécialement adaptés à leur fabrication
B01D 71/44 - Polymères obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, non prévus dans un seul des groupes
C07K 1/34 - Extraction; Séparation; Purification par filtration, ultrafiltration ou osmose inverse
C07K 1/36 - Extraction; Séparation; Purification par une combinaison de plusieurs procédés de types différents
C07K 16/00 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux
B01D 15/00 - Procédés de séparation comportant le traitement de liquides par des adsorbants ou des absorbants solides; Appareillages pour ces procédés
Provided is a blood purifier which has a porous molded body with good phosphorus adsorption, which has good cytokine adsorption performance, no hemolysis, and can be used safely. The blood purifier has a porous molded body having a low-melting-point moisture content per gram of dry weight of 0.12 g or more and 1.35 g or less. After three and six months from sealing of a saline solution for injection into the blood purifier, the number of microparticles greater than or equal to 10 µm is 25 or less and the number of microparticles greater than or equal to 25 µm is three or less in 1 mL of the saline solution for injection.
B01J 20/06 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant des oxydes ou des hydroxydes des métaux non prévus dans le groupe
B01J 20/08 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant des oxydes ou des hydroxydes des métaux non prévus dans le groupe contenant de la bauxite
B01J 20/10 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant de la silice ou un silicate
B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques
B01J 20/30 - Procédés de préparation, de régénération ou de réactivation
A61M 1/02 - Appareils pour transfusion sanguine d'un corps à un autre
A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p.ex. adaptation de la température, irradiation
Provided is a blood purifier which includes a porous formed body and which has excellent blood compatibility, in which platelets are unlikely to adhere, has good cytokine adsorption capacity, and low pressure loss before and after treating blood, and can be safely used. Disclosed is a blood purifier having a body container, and a porous formed body accommodated in the body container. The porous formed body contains a hydrophobic polymer and a hydrophilic polymer, the low-melting-point water content per 1 g of dry weight of the porous formed body is 0.12-2.00 g, the rate of contact change of the porous formed body is 0-0.2%, and the adhering amount of platelets per 1 mL of blood is 0.400 billion/mL or less when brining the blood into contact with the porous formed body.
B01J 20/06 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant des oxydes ou des hydroxydes des métaux non prévus dans le groupe
B01J 20/08 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant des oxydes ou des hydroxydes des métaux non prévus dans le groupe contenant de la bauxite
B01J 20/10 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant de la silice ou un silicate
B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques
B01J 20/30 - Procédés de préparation, de régénération ou de réactivation
A61M 1/02 - Appareils pour transfusion sanguine d'un corps à un autre
A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p.ex. adaptation de la température, irradiation
63.
Virus removal membrane and method for manufacturing virus removal membrane
A virus removal membrane includes cellulose, and a primary-side surface through which the protein-containing solution is to be applied and a secondary-side surface from which a permeate that has permeated the virus removal membrane is to be flowed, wherein a bubble point is 0.5 MPa or more and 1.0 MPa or less; and when a solution containing gold colloids having a diameter of 30 nm is applied through the primary-side surface to the virus removal membrane to allow the virus removal membrane to capture the gold colloids for measurement of brightness in a cross section of the virus removal membrane, a value obtained by dividing a standard deviation of a value of an area of a spectrum of variation in the brightness by an average of the value of the area of the spectrum of variation in the brightness is 0.01 or more and 0.30 or less.
B01D 65/10 - Test de membranes ou d'appareils à membranes; Détection ou réparation de fuites
B01D 67/00 - Procédés spécialement adaptés à la fabrication de membranes semi-perméables destinées aux procédés ou aux appareils de séparation
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétés; Procédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
D01D 5/24 - Formation des filaments, fils ou similaires à structure creuse; Ensembles de filage à cet effet
D01F 2/04 - Filaments, ou similaires, artificiels, à un seul composant, formés de cellulose ou de dérivés de la cellulose; Leur fabrication obtenus à partir de solutions de cellulose dans des acides, des bases ou des sels obtenus à partir de solutions cupro-ammoniacale
Surgical, medical, dental and veterinary equipment,
apparatus and instruments; hemodialyzers and parts thereof;
hemofilters and parts thereof; hemodiafilters and parts
thereof; blood purification equipment, apparatus and
instruments, and parts thereof; plasma separating filter and
parts thereof; plasma component fractionating filter and
parts thereof; hollow fiber membrane for medical use; tubing
sets used for blood purification equipment, apparatus and
instruments; blood cells adsorber; blood component adsorber;
ascites filter and ascites concentrator; blood component
separation device, equipment, apparatus and instruments;
needles for medical purposes.
Surgical, medical, dental and veterinary equipment,
apparatus and instruments; hemodialyzers and parts thereof;
hemofilters and parts thereof; hemodiafilters and parts
thereof; blood purification equipment, apparatus and
instruments, and parts thereof; plasma separating filter and
parts thereof; plasma component fractionating filter and
parts thereof; hollow fiber membrane for medical use; tubing
sets used for blood purification equipment, apparatus and
instruments; blood cells adsorber; blood component adsorber;
ascites filter and ascites concentrator; blood component
separation device, equipment, apparatus and instruments;
needles for medical purposes.
66.
BLOOD PURIFICATION DEVICE AND EXTRACORPOREAL BLOOD CIRCULATION SYSTEM PROVIDED WITH BLOOD COMPONENT ADJUSTER
Provided is an extracorporeal blood circulation device which is provided with a blood purification device and a blood component adjuster and which can be safely used. The present invention relates to an extracorporeal blood circulation device provided with: a blood component adjuster; a blood purification device; a pipe system provided with a pump for supplying blood from a blood collecting part to the blood component adjuster, a valve for supplying a physiological saline solution, and a pressure gauge for sensing a pressure loss; a bypass pipe system for bypassing the blood component adjuster and supplying blood to the blood purification device; a pipe system for connecting the blood component adjuster and the blood purification device, the pipe system being provided with a pressure gauge for sensing a pressure loss; a pipe system provided with a valve for returning blood from the blood purification device to a reinfusion part and recovering the physiological saline solution, and a pressure gauge for sensing a pressure loss; and a control unit having a function for switching to the bypass pipe system on the basis of a pressure loss in the blood component adjuster, and a function for switching to a reinfusion mode on the basis of a pressure loss in the blood purification device.
The present invention provides a phosphate adsorbing agent for blood processing comprising a porous formed article comprising an organic polymer resin and an inorganic ion adsorbent and having a most frequent pore size of 0.08 to 0.70 μm measured with a mercury porosimeter, the phosphate adsorbing agent for blood processing having a biocompatible polymer in the surface of the porous formed article.
B01J 47/014 - Procédés d'échange d'ions en général; Appareillage à cet effet dans lesquels les propriétés d’adsorption de l’échangeur d’ions sont utilisées, p.ex. récupération de protéines ou de composés macromoléculaires
A61M 1/16 - Systèmes de dialyse; Reins artificiels; Oxygénateurs du sang avec membranes
B01J 41/13 - Composés macromoléculaires obtenus autrement que par des réactions ne faisant intervenir que des liaisons carbone-carbone non saturées
B01D 15/36 - Adsorption sélective, p.ex. chromatographie caractérisée par le mécanisme de séparation impliquant une interaction ionique, p.ex. échange d'ions, paire d'ions, suppression d'ions ou exclusion d'ions
B01J 41/02 - Procédés utilisant des échangeurs inorganiques
B01J 41/04 - Procédés utilisant des échangeurs organiques
The present invention provides a blood processing filter including: a container with two openings for the entry of a liquid to be processed and for the exit of a liquid that has been processed; and a filtering material filled in the container. The filtering material has a ventilation resistance of not less than 55.0 kPa·s/m and less than 85.0 kPa·s/m. The filtering material includes a filter material A of which ventilation resistance per unit area is not less than 0.01 kPa·s·m/g and less than 0.04 kPa·s·m/g, and a filter material B of which the ventilation resistance per unit area is not less than 0.04 kPa·s·m/g. At least a part of the filter material A is disposed on the side closer to the entry of the liquid to be processed than the filter material B. The total of the ventilation resistance of the filter material A disposed on the side closer to the entry of the liquid to be processed than the filter material B is not less than 6.0 kPa·s/m.
Provided are beads for blood processing having porous beads and a polymer carried on the surface of the porous beads, wherein: the porous beads are configured from at least one resin selected from the group consisting of acrylic resins, styrene resins, and cellulose resins; and the polymer includes a specific monomer defined in the description as a monomer unit.
B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques
Surgical, medical, dental and veterinary equipment,
apparatus and instruments; hemodialyzers and parts thereof;
hemofilters and parts thereof; hemodiafilters and parts
thereof; blood purification equipment, apparatus and
instruments, and parts thereof; plasma separating filter and
parts thereof; plasma component fractionating filter and
parts thereof; hollow fiber membrane for medical use; tubing
sets used for blood purification equipment, apparatus and
instruments; blood cells adsorber; blood component adsorber;
ascites filter and ascites concentrator; blood component
separation device, equipment, apparatus and instruments;
needles for medical purposes.
An aspect of the present application comprises a leak detection device (1) for detecting leaks from a filtration membrane M, the device being provided with: a container (10) that is separated into two spaces due to the filtration membrane M being disposed therein; a liquid storage container (20) for storing liquid to be supplied to the container (10); a first connection pipe (30) for connecting the liquid storage container (20) with either one of the spaces inside the container (10); a gas supply device (40) for supplying a gas to the container (10); a second connection pipe (50) for connecting the gas supply device (40) to the container (10); closing means (61, 62, 63) provided in the first connection pipe (30) and/or the second connection pipe (50); and a detection member (70) for detecting leaking of the gas supplied by the gas supply device (40) from the filtration membrane M.
Provided is a blood purification device comprising a porous molded body that has a high phosphorus adsorption capacity and that can be used safely. A blood purification device according to the present invention comprises a porous molded body containing an inorganic ion-adsorbing material and is characterized by the following: said blood purification device satisfies the relationship B = -0.02A + 2.175 ± 0.185 (74 ≤ A ≤ 94) when the moisture content of the porous molded body is denoted by A and the bulk density is denoted by B; and the number of fine particles having a size of 10 µm or more is 25 or less and the number of fine particles having a size of 25 µm or more is 3 or less in 1 mL of a physiological saline solution for injection both three months and six months after said physiological saline solution for injection is sealed in the blood purification device.
A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p.ex. adaptation de la température, irradiation
B01J 20/06 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant des oxydes ou des hydroxydes des métaux non prévus dans le groupe
B01J 20/08 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant des oxydes ou des hydroxydes des métaux non prévus dans le groupe contenant de la bauxite
B01J 20/10 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant de la silice ou un silicate
Provided is a blood purification device comprising a porous molded body that has a high phosphorus adsorption capacity and that can be used safely. A blood purification device according to the present invention comprises a porous molded body containing an inorganic ion-adsorbing material and is characterized by the following: the concentrations of Mg, Al, Ti, V, Cr, Mn, Fe, Ni, Cu, Zn, Ga, Rb, Sr, Y, Zr, Mo, Ru, Ag, Cd, Sn, Cs, La, Pr, Sm, Gd, Tb, Ta, Au, Tl, Co, In, and Bi are each 0.1 ppb or less and the concentrations of Ba, Nd, Pb, And Ce are each 1 ppb or less in a physiological saline solution for injection both three months and six months after said physiological saline solution for injection is sealed in the blood purification device; and the number of fine particles having a size of 10 µm or more is 25 or less and the number of fine particles having a size of 25 µm or more is 3 or less in 1 mL of the physiological saline solution for injection both three months and six months after said physiological saline solution for injection is sealed in the blood purification device.
A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p.ex. adaptation de la température, irradiation
B01J 20/06 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant des oxydes ou des hydroxydes des métaux non prévus dans le groupe
B01J 20/08 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant des oxydes ou des hydroxydes des métaux non prévus dans le groupe contenant de la bauxite
B01J 20/10 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant de la silice ou un silicate
Provided is a blood processing filter comprising a container having two spouts serving as an inlet for a liquid to be processed and an outlet for the processed liquid, and a filtration medium contained in the container, the filtration medium comprising a filter material having different CWST values for one surface A and the other surface B.
A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p.ex. adaptation de la température, irradiation
A61M 1/02 - Appareils pour transfusion sanguine d'un corps à un autre
B01D 39/16 - Autres substances filtrantes autoportantes en substance organique, p.ex. fibres synthétiques
B01D 67/00 - Procédés spécialement adaptés à la fabrication de membranes semi-perméables destinées aux procédés ou aux appareils de séparation
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétés; Procédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
B01D 69/10 - Membranes sur support; Supports pour membranes
76.
BLOOD PURIFYING DEVICE, METHOD FOR OBTAINING TRANSMEMBRANE PRESSURE DIFFERENCE ACROSS BLOOD PURIFICATION MEMBRANE, AND METHOD, DEVICE AND PROGRAM FOR DETERMINING SAME
The objective of the present invention is to control an amount of leakage of albumin in blood while suppressing leakage of the albumin when blood is being purified using a blood purification membrane. A blood purifying device 1 includes a control means for controlling a transmembrane pressure difference across a blood purification membrane of a blood purifier. The control means obtains the transmembrane pressure difference Pa (Tn) corresponding to a target solute leakage concentration Na (Tn) at each of at least one predetermined time Tn, on the basis of a function Fn: N(Tn)=Fn(P(Tn), Tn) (where n is an integer equal to or greater than 1) representing a relationship between a transmembrane pressure difference P (Tn) at at least one predetermined time Tn after the start of blood purification and a solute leakage concentration N (Tn) of a predetermined solute in the blood, and controls the transmembrane pressure difference during blood purification on the basis of the transmembrane pressure difference Pa (Tn).
A method for filtering a protein-containing liquid containing protein at a concentration of 20 mg/mL or more and 100 mg/mL or less, the method including a prefiltration step of filtering the protein-containing liquid by a prefilter having a pore size of 0.08 µm to 0.25 µm and including a hydrophobic resin, and a virus removal step of filtering the protein-containing liquid by a virus removal membrane including a synthetic polymer, after the prefiltration step, wherein the protein-containing liquid before conducting the prefiltration step includes 0.25 g or more of a trimer or higher multimer of the proteins having an average diameter of less than 100 nm, per 1 m2 of the virus removal membrane.
A filtration method for a protein-containing liquid, said liquid containing a protein at a concentration of 20-100 mg/mL inclusive, which comprises a prefiltration step for filtering the protein-containing liquid through a prefilter, said prefilter having a pore diameter of 0.08-0.25 μm and comprising a hydrophobic resin, and a virus removal step for, after the prefiltration step, filtering the protein-containing liquid through a virus removal membrane comprising a synthetic polymer, wherein the protein-containing liquid before subjected to the prefiltration step contains a trimeric or larger protein multimer, which has an average diameter of less than 100 nm, in an amount of 0.25 g or greater per square meter of the virus removal membrane.
50/mL)}:{impurity protein concentration (ng/mL)} ratio more than 5000:1; and a method of producing such a high-infectivity titer and high-purity parvovirus.
The present invention provides a phosphorus adsorbent for blood treatment. The phosphorus absorbent: includes a porous molded body that contains an organic polymer resin and an inorganic ion adsorbent and that has a most frequent pore diameter as determined by a mercury porosimeter of 0.08 to 0.70 µm; and includes a biocompatible polymer at the surface of the porous molded body.
A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p.ex. adaptation de la température, irradiation
B01J 20/06 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant des oxydes ou des hydroxydes des métaux non prévus dans le groupe
B01J 20/08 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant des oxydes ou des hydroxydes des métaux non prévus dans le groupe contenant de la bauxite
B01J 20/10 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant de la silice ou un silicate
B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques
81.
BLOOD PURIFICATION DEVICE, CONTROL METHOD THEREOF, AND BLOOD REMOVAL DEFECT ELIMINATION METHOD
In a blood purification device which removes blood through a puncture needle, in order to effectively eliminate blood removal defects resulting from a patient's blood vessel sticking to the hole in the puncture needle, this blood purification device 1 is provided with a blood removal line 10 which allows blood extracted from a patient P to circulate through a blood purifier 20, a blood pump 30 on the blood removal line 10, a pressure sensor 40 upstream of the blood pump 30 in the blood removal line 10, an infusion line 50 which supplies the infusion liquid upstream of the blood pump 30 in the blood removal line 10, an infusion container 60 which is connected to the infusion line 50, an opening/closing valve 70 which opens and closes the infusion line 50, and a control unit 80 which controls the blood pump 30 and the opening/closing valve 70. The infusion container 60 is arranged directly above the patient P. The control unit 80 opens the infusion line 50 with the opening/closing valve 70 if the pressure measured by the pressure sensor 40 during operation of the blood pump 30 falls below a prescribed value.
Provided is a blood purification device in which an infusion line for supplying an infusion of an anticoagulant or the like is connected to a blood removal line, wherein blood can be returned automatically without the need to reverse the rotation of a blood pump and without the need to provide an infusion supply means for retransfusion to a downstream side of the blood pump. A control unit 80 of a blood purification device 1: stops operation of a blood pump 30 and infusion pump 52, and opens a first infusion line 40 with a first on/off valve 42 and closes a blood removal line 10 with a second on/off valve 11; rotates the blood pump 30 forward by a predetermined amount X, and causes a first infusion to move from the first infusion line 40 to the blood removal line 10; rotates the infusion pump 52 backward by a predetermined amount Y, and causes the first infusion in the blood removal line 10 to move to a second infusion line 50; closes the first infusion line 40 with the first on/off valve 42 and opens the blood removal line 10 with the second on/off valve 11; and rotates the infusion pump 52 forward by a predetermined amount Z, and causes the first infusion in the second infusion line 50 to move to the blood removal line 10 and return to a patient P. Due to this configuration, automatic retransfusion to the patient P can be achieved.
When air bubbles are detected during priming of a blood purification device, in order to remove the air bubbles automatically while maintaining cleanliness of the equipment, this blood purification device 1 is provided with: a blood purifier 10; a cleaning liquid storage unit 20 in which a cleaning liquid is stored; a cleaning flow path 30 which connects the blood purifier 10 and the cleaning liquid storage unit 20; a detector 40 which is provided in the cleaning flow path 30 and detects air bubbles; a discharge flow path 50 which communicates with the blood purifier 10 and discharges the cleaning liquid; an infusion liquid storage unit 60 which stores an infusion liquid; a pump 80 which is provided in the flow path between the detector 40 and the infusion liquid storage unit 60; and a control unit 90 which, if the detector 40 has detected air bubbles, operates the pump 80 so as to supply the infusion liquid from the infusion liquid storage unit 60, through the detector 40 and to the cleaning liquid storage unit 20.
Provided is a blood purification device that includes a blood circuit, a waste liquid circuit, a citric acid solution feeding means, and a calcium solution feeding means. The blood purification device is configured such that when a citric acid solution has been fed by the citric acid solution feeding means, the total calcium flow rate in waste liquid is calculated from the total calcium concentration of the waste liquid in the waste liquid circuit and the waste liquid flow rate in the waste liquid circuit, and the flow rate of calcium solution to be fed by the calcium solution feeding means is determined from the total calcium flow rate in the waste liquid.
Provided is a blood purification device that comprises a blood circuit, a blood purifier, a citric acid solution supplying means, and a calcium solution supplying means. The blood purification device is configured so as to: estimate a calcium reduction quantity for reduction in the blood circuit overall, including a removal quantity of calcium to be removed with the blood purifier when blood of a target calcium ion concentration flows through the blood circuit, on the basis of a target calcium ion concentration of patient blood that has been inputted; calculate a supplied quantity of calcium solution to be supplied to the blood circuit on the basis of the calcium reduction quantity; and supply the calcium solution to the blood circuit with the calcium solution supplying means on the basis of the supplied quantity of calcium solution.
The present invention provides a filter element for a blood processing filter, comprising a nonwoven fabric, wherein the quantity of crystallization heat of the uncrystallized portion of the nonwoven fabric is 5 J/g or smaller before steam heat treatment.
A61M 1/02 - Appareils pour transfusion sanguine d'un corps à un autre
B01D 39/16 - Autres substances filtrantes autoportantes en substance organique, p.ex. fibres synthétiques
A61M 1/34 - Filtration du sang à travers une membrane pour en éliminer une matière, c. à d. hémofiltration, diafiltration
B01D 29/00 - Filtres à éléments filtrants stationnaires pendant la filtration, p.ex. filtres à aspiration ou à pression, non couverts par les groupes ; Leurs éléments filtrants
87.
POROUS FILM AND METHOD FOR MANUFACTURING POROUS FILM
A porous film that contains a thermoplastic resin and that is provided with a dense structure layer, the proportion of α-crystal strength relative to β-crystal strength of the thermoplastic resin in the dense structure layer being 5.0 or above.
B01D 69/00 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétés; Procédés spécialement adaptés à leur fabrication
B01D 67/00 - Procédés spécialement adaptés à la fabrication de membranes semi-perméables destinées aux procédés ou aux appareils de séparation
C08J 9/26 - Mise en œuvre de substances macromoléculaires pour produire des matériaux ou objets poreux ou alvéolaires; Leur post-traitement par élimination d'une phase solide d'un objet ou d'une composition macromoléculaire, p.ex. par lessivage
Surgical, medical, dental and veterinary equipment,
apparatus and instruments; hemodialyzers and parts thereof;
hemofilters and parts thereof; hemodiafilters and parts
thereof; blood purification equipment, apparatus and
instruments, and parts thereof; plasma separating filter and
parts thereof; plasma component fractionating filter and
parts thereof; hollow fiber membrane for medical use; tubing
sets used for blood purification equipment, apparatus and
instruments; blood cells adsorber; blood component adsorber;
ascites filter and ascites concentrator; blood component
separation device, equipment, apparatus and instruments.
89.
STRONG CATION EXCHANGE CHROMATOGRAPHY CARRIER AND USE OF SAME
A cation exchange chromatography carrier which is provided with: a substrate; and a copolymer that is immobilized on the substrate and comprises one monomer unit which has at least a sulfonic acid group. This cation exchange chromatography carrier is configured such that: the copolymer does not substantially have a crosslinked structure; the copolymer does not contain acrylamide and an acrylamide derivative as a monomer unit, or contains acrylamide and an acrylamide derivative in such an amount that does not have a substantial effect; the ratio of the mass of the copolymer to the mass of the substrate is from 5% to 200% (inclusive); and the density of the sulfonic acid groups is more than 30 mmol/L but 200 mmol/L or less.
G01N 30/88 - Systèmes intégrés d'analyse, spécialement adaptés à cet effet, non couverts par un seul des groupes
B01D 15/36 - Adsorption sélective, p.ex. chromatographie caractérisée par le mécanisme de séparation impliquant une interaction ionique, p.ex. échange d'ions, paire d'ions, suppression d'ions ou exclusion d'ions
B01J 39/07 - Procédés utilisant des échangeurs organiques sous forme faiblement acide
B01J 39/20 - Composés macromoléculaires obtenus par des réactions ne faisant intervenir que des liaisons carbone-carbone non saturées
B01J 39/26 - Echange de cations; Utilisation d'une substance comme échangeur de cations; Traitement d'une substance en vue d'améliorer ses propriétés d'échange de cations Échangeurs de cations pour procédés chromatographiques
B01J 47/12 - Procédés d'échange d'ions en général; Appareillage à cet effet caractérisés par l'emploi d'une substance échangeur d'ions sous forme de rubans, de filaments, de fibres ou de feuilles, p.ex. sous forme de membranes
C07K 16/00 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux
C08F 255/02 - Composés macromoléculaires obtenus par polymérisation de monomères sur des polymères d'hydrocarbures tels que définis dans le groupe sur des polymères d'oléfines contenant deux ou trois atomes de carbone
A filter element for a blood processing filter, containing a nonwoven fabric, wherein the nonwoven fabric has a carboxyl group equivalent of from 20 to 140 (µeq/g) and a surface potential of 0 mV or larger.
A filter element for a blood treatment filter, including a non-woven fabric having a carboxyl group equivalent of 20–140 (µeq/g) and a surface ζ potential of at least 0 mV.
The present invention provides a method for treating a solution contaminated with porcine circoviruses, said method comprising the steps of: adjusting the pH value of the solution contaminated with porcine circoviruses to 3.0 to 7.0; and treating the pH-adjusted solution using a filtration membrane having a LRV for bacteriophage PP7 of 4 or more.
A polyethylene resin porous hollow fiber membrane having a plurality of microfibrils which include a polyethylene resin and which are aligned in the fiber longitudinal direction, and nodular parts comprising a lamellar laminate connected to both ends of the microfibrils, wherein the mass fraction of components having a molecular weight of 10,000 or less is 17.5 mass% or above, and the mass fraction of components having a molecular weight of 1,000,000 or higher is less than 1.5 mass%.
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétés; Procédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
Surgical, medical, dental and veterinary equipment,
apparatus and instruments; hemodialyzers and parts thereof;
hemofilters and parts thereof; hemodiafilters and parts
thereof; blood purification equipment, apparatus and
instruments, and parts thereof; plasma separating filter and
parts thereof; plasma component fractionating filter and
parts thereof; hollow fiber membrane for medical use; tubing
sets used for blood purification equipment, apparatus and
instruments; blood cells adsorber; blood component adsorber;
ascites filter and ascites concentrator; blood component
separation device, equipment, apparatus and instruments.
95.
VIRUS REMOVAL MEMBRANE AND METHOD FOR MANUFACTURING VIRUS REMOVAL MEMBRANE
A virus removal membrane for removing a virus from a solution containing a protein, wherein the virus removal membrane is provided with cellulose and has a primary-side surface that is supplied with a solution containing a protein, and a secondary-side surface from which a permeated liquid that has permeated the virus removal membrane is discharged, the bubble point of the virus removal membrane being 0.5-1.0 MPa, a solution containing metal colloids having a diameter of 30 nm being supplied from the primary side to the virus removal membrane and the metal colloids being captured by the virus removal membrane, and, when luminance is measured in a cross-section of the virus removal membrane, the value obtained by dividing the standard deviation of the area value of a spectrum of luminance displacement by the average value of the area value of the spectrum of luminance displacement is 0.01-0.30.
C07K 1/34 - Extraction; Séparation; Purification par filtration, ultrafiltration ou osmose inverse
A61L 2/02 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contact; Accessoires à cet effet utilisant des phénomènes physiques
B01D 65/10 - Test de membranes ou d'appareils à membranes; Détection ou réparation de fuites
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétés; Procédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
D01D 5/24 - Formation des filaments, fils ou similaires à structure creuse; Ensembles de filage à cet effet
D01F 2/04 - Filaments, ou similaires, artificiels, à un seul composant, formés de cellulose ou de dérivés de la cellulose; Leur fabrication obtenus à partir de solutions de cellulose dans des acides, des bases ou des sels obtenus à partir de solutions cupro-ammoniacale
The hollow fiber membrane module pertaining to the present invention is provided with: a cylindrical container (2) in which one end part and the other end part thereof are open; a hollow fiber membrane bundle (3) loaded in the cylindrical container (2); a potting part (4) in which the hollow fiber membrane bundle (3) is embedded and fixed in both end parts of the cylindrical container (2); and a header (5) having a nozzle as a fluid exit/entrance, the header (5) being provided to both end parts of the cylindrical container (2). In the hollow fiber membrane module, the header (5) and the cylindrical container (2) are welded in at least the two locations of a primary weld part (71) and a secondary weld part (72), the secondary weld part (72) being disposed in a position at which welding is initiated after or at the same time as the start of welding of the primary weld part (71).
A hollow fiber membrane module 1 has: a cylindrical container 2 for accommodating a hollow fiber membrane bundle 3; a header 5; and a potting unit 4. The header 5 has a header protrusion 22 protruding in a circular shape to the cylindrical container 2 side. The cylindrical container 2 has an inside protrusion 50 and an outside protrusion 51 protruding in a double circular shape to the header 5 side. The header 5 and the cylindrical container 2 are welded by ultrasonic welding in a state wherein the header protrusion 22 is inserted between the inside protrusion 50 and the outside protrusion 51 of the cylindrical container 2. The header protrusion 22 and the inside protrusion 50 of the cylindrical container 2 are welded in at least one area, and the header protrusion 22 and the outside protrusion 51 of the cylindrical container 2 are welded in at least one area.
A virus removal membrane for removing a virus from a solution containing a protein, wherein the virus removal membrane is provided with cellulose and has a primary-side surface that is supplied with a solution containing a protein, and a secondary-side surface from which a permeated liquid that has permeated the virus removal membrane is discharged, the bubble point of the virus removal membrane being 0.5-1.0 MPa, a solution containing metal colloids having a diameter of 30 nm being supplied from the primary side to the virus removal membrane and the metal colloids being captured by the virus removal membrane, and, when luminance is measured in a cross-section of the virus removal membrane, the value obtained by dividing the standard deviation of the area value of a spectrum of luminance displacement by the average value of the area value of the spectrum of luminance displacement is 0.01-0.30.
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétés; Procédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
B01D 65/10 - Test de membranes ou d'appareils à membranes; Détection ou réparation de fuites
D01D 5/24 - Formation des filaments, fils ou similaires à structure creuse; Ensembles de filage à cet effet
D01F 2/04 - Filaments, ou similaires, artificiels, à un seul composant, formés de cellulose ou de dérivés de la cellulose; Leur fabrication obtenus à partir de solutions de cellulose dans des acides, des bases ou des sels obtenus à partir de solutions cupro-ammoniacale
99.
BLOOD PURIFICATION SYSTEM AND METHOD FOR PRIMING OF SAME
The purpose of the present invention is to provide a blood purification system which is capable of reducing an operating burden associated with priming, etc., thereby contributing to greater error avoidance, said blood purification system also having superior universality, and a method for priming of said blood purification system. This online blood purification system comprises: a blood purification device which further comprises a first space and second spaces which are partitioned with blood purification membranes, and which passes extracorporeally circulating blood through the first space and purifying said blood; a blood inlet-side flow path wherethrough the extracorporeally circulating blood flows prior to flowing into the first space; a blood outlet-side flow path wherethrough the extracorporeally circulating blood flows after having flowed out from the first space; a fluid supply flow path for supplying a fluid to the second spaces; a fluid recovery flow path for recovering the fluid from the second spaces; an arterial-side fluid replacement supply flow path which branches off of the fluid supply path, and which is connected to the blood inlet-side flow path; and a venous-side fluid replacement supply flow path which branches off of the fluid supply flow path, and which is connected to the blood outlet-side flow path. The arterial-side fluid replacement supply flow path and the venous-side fluid replacement supply flow path further comprise respective fluid transporting means which are capable of being independently controlled.
The object of the present invention is to provide a porous membrane by which a useful component can be recovered while suppressing the clogging during filtration of a protein solution and from which only a small amount of an eluate is eluted even when an aqueous solution is filtered.
The present invention provides a porous membrane containing a hydrophobic polymer and a water-insoluble hydrophilic polymer, the porous membrane having a dense layer in the downstream portion of filtration in the membrane, having a gradient asymmetric structure in which the average pore diameter of fine pores increases from the downstream portion of filtration toward the upstream portion of filtration, and having a gradient index of the average pore diameter from the dense layer to the coarse layer of 0.5 to 12.0.
B01D 69/00 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétés; Procédés spécialement adaptés à leur fabrication
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétés; Procédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés