Disclosed herein are assay methods and kits for assessing the strength of the immune response to SARS-CoV-2 virus in a subject by allowing for rapid and efficient detection of neutralizing antibodies (NAbs) from serum of vaccinated and non-vaccinated subjects. The assay method can be conducted in a biosafety level 2 setting, and uses highly-purified, monomeric SARS-Cov-2-Spike1 which leads to improved sensitivity and specificity over current state of the art assays.
G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Medical diagnostic rapid point-of-care test kits comprised
of medical diagnostic reagents and assays for testing of
bodily fluids for use in disease detection, namely,
hepatitis C (HCV), hepatitis B sAg (HBsAg), syphilis,
syphilis/HIV combination and malaria; medical diagnostic
rapid point-of-care test kits comprised of medical
diagnostic reagents and assays for testing of bodily fluids
for detection of pregnancy.
An aqueous composition for stabilizing nucleic acid contained in a biological sample at ambient temperature is provided. The aqueous composition comprises: (i) a denaturing agent selected from sodium dodecyl sulphate (SDS) or a guanidinium salt; (ii) aurintricarboxylic acid (ATA); and (iii) at least one of a chelating agent and a buffering agent; wherein the composition has a pH of 4.9 or less. A method of stabilizing nucleic acid contained in a biological sample at ambient temperature is also provided, wherein the method comprises the steps of: a) obtaining a biological sample; b) contacting the biological sample with the above-noted aqueous composition to form a mixture; c) homogenizing the mixture of (b) to form a homogeneous mixture; and d)storing the homogeneous mixture at ambient temperature.
The invention relates to a direct sample collection pad for assay diagnosis of a sample without introducing an additional sampling device into the assay method. This simplifies the system and method of sample collection and assay diagnosis, thus reducing waste and potential for patient irritation or injury during diagnosis.
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
An oral fluid collection device includes a plunger and funnel to simultaneously collect and split a single specimen into metered doses for drug testing. The device may be used with collection tubes for collection of the metered doses and later testing. The device, when used, drives the metered dose into the collection tubes and removes bubbles in the specimen to provide improved accuracy in testing.
A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
8.
PRODUCTS AND METHODS FOR MONITORING ADHERENCE TO NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR THERAPY
The invention provides novel compounds, reagents, systems, and methods for detecting a metabolite related to a NRTI in a biological sample and use thereof in monitoring adherence to pre-exposure prophylaxis or anti-retroviral treatment. Such reagents comprise NRTI derivatives, analogs, NRTI derivatives conjugates, along with antibodies directed to same, which are useful for antibody-based methods, such as a lateral flow immunoassay and other point of care devices.
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
C07K 16/44 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel non prévu ailleurs
C12N 9/16 - Hydrolases (3.) agissant sur les liaisons esters (3.1)
A biological sample collection system comprising a containment vessel and a sample collection assembly connected thereto is provided. The assembly comprises a sample collector threadedly engaged with a sample collection vessel having a sample receiving area for receiving the biological sample from the sample collector. The collector comprises a valve stem comprising a valve face, and the collection vessel comprises a complementary valve seat. The valve stem and valve seat form a valve comprising a closed configuration wherein threaded connection members of the collector and the collection vessel are fully engaged, and an open configuration wherein the threaded connection members are less than fully engaged. In the closed configuration, the valve face forms a sealing engagement with the valve seat. In the open configuration, the valve face is spaced apart from the valve seat to place the containment vessel, collection vessel, and collector in fluid communication with one another.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Medical diagnostic rapid point-of-care test kits comprised of medical diagnostic reagents and assays for testing of bodily fluids for use in disease detection, namely, hepatitis C (HCV), hepatitis B sAg (HBsAg), syphilis, syphilis/HIV combination and malaria; Medical diagnostic rapid point-of-care test kits comprised of medical diagnostic reagents and assays for testing of bodily fluids for detection of pregnancy
11.
METHOD FOR COLLECTING AND PRESERVING A BIOLOGICAL SAMPLE
The disclosure relates to devices, solutions and methods for collecting and processing samples of bodily fluids containing cells (as well as embodiments for the collection, and processing and/or analysis of other fluids including toxic and/or hazardous substances/fluids). In addition, the disclosure relates generally to function genomic studies and to the isolation and preservation of cells from saliva and other bodily fluids (e.g., urine), for cellular analysis. With respect to devices for collection of bodily fluids, some embodiments include two mating bodies, a cap and a tube (for example), where, in some embodiments, the cap includes a closed interior space for holding a sample preservative solution and mates with the tube to constitute the (closed) sample collection device. Upon mating, the preservation solution flows into the closed interior space to preserve cells in the bodily fluid. The tube is configured to receive a donor sample of bodily fluid (e.g., saliva, urine), which can then be subjected to processing to extract a plurality of cells. The plurality of cells can be further processed to isolate one and/or another cell type therefrom. The plurality of cells, as well as the isolated cell type(s), can be analyzed for functional genomic and epigenetic studies, as well as biomarker discovery.
A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
G01N 1/10 - Dispositifs pour prélever des échantillons à l'état liquide ou fluide
The present application is to provide a composition and method for stabilizing and maintaining the viability of hardy microorganisms from sample collection to downstream analysis. In particular, there is a method for preserving viable hardy bacteria, such as Mycobacteria, Bacillus anthracis, or Clostridium difficile, in a biological sample, comprising contacting the biological sample with a stabilization composition, wherein the stabilization composition comprises a chelating agent, a denaturing, a salt and has a p H between about 6 and about 11.
C12Q 1/00 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions
C12N 1/04 - Conservation des micro-organismes à l'état viable
C12Q 1/24 - Méthodes d'échantillonnage, d'inoculation ou de développement d'un échantillonMéthodes pour isoler physiquement un micro-organisme intact
14.
BIOLOGICAL SAMPLE COLLECTION SYSTEM WITH PUSH-ACTIVATED VALVE FOR SAMPLE RELEASE
A biological sample collection system is provided, the system comprising: a containment vessel; a sample collection reservoir disposed toward a first end of the containment vessel and comprising a valve disposed in a sample receiving area, the valve comprising: a closed configuration, wherein when the valve is in the closed configuration the biological sample is retained in the sample collection reservoir, and an open configuration, wherein when the valve is in the open configuration the biological sample is released from the sample collection reservoir into a sample storage chamber of the containment vessel; and a cap comprising a pusher; wherein, when the biological sample collection system is closed by engagement of the containment vessel with the cap, the pusher engages with the valve thereby moving the valve from the closed configuration to the open configuration to permit the biological sample to be released from the sample collection reservoir into the containment vessel.
Method and systems are provided for defining test sample read count limits for a range of microbial sequence reads. A computing device may generate a stabilization framework usable to determine a viability of a stabilization solution to stabilize a particular microbial species. The stabilization framework may include a first read count limit defined based on an enumerated abundance of the microbial species in a control sample multiplied by a first sequencing range value. The computing device may receive a read count value corresponding to an enumerated abundance of the microbial species in a mixture comprising a biological sample and the stabilization solution. The stabilization framework maybe applied to the read count value to generate an output based on whether the read count value exceeds the first read count limit. The computing device may then select, the stabilizing solution for use with subsequent biological samples.
The present invention generally relates to a sample receiving device for releasably storing a substance. The sample receiving device includes a lid having a reservoir for retaining the substance, and a pierceable barrier sealing the substance within the reservoir; and b) a funnel for receiving a sample and configured for closure by the lid. The funnel is configured for releasable attachment to a sample receptacle such that a sample can be provided to the funnel and travel through the channel in the funnel into the sample receptacle. Further, the funnel includes one or more cutting ribs for cutting the pierceable barrier such that upon cutting of the pierceable barrier the substance is released from the reservoir, flows through the channel in the funnel and into the sample receptacle to be mixed with the sample. The present invention also provides a kit for collecting and storing biomolecules.
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
Disclosed herein are assay methods and kits for for assessing the strength of the immune response to SARS-CoV-2 virus in a subject by allowing for rapid and efficient detection of neutralizing antibodies (NAbs) from serum of vaccinated and non-vaccinated subjects. The assay method can be conducted in a biosafety level 2 setting, and uses highly-purified, monomeric SARS-Cov-2-Spikel which leads to improved sensitivity and specificity over current state of the art assays.
G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
A61K 39/215 - Coronaviridae, p. ex. virus de la bronchite infectieuse aviaire
C07K 14/165 - Coronaviridae, p. ex. virus de la bronchite infectieuse aviaire
C07K 16/10 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus de virus à ARN
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
22.
LOW PH COMPOSITION AND METHOD FOR STABILIZING NUCLEIC ACIDS IN BIOLOGICAL SAMPLES
An aqueous composition for stabilizing nucleic acid contained in a biological sampleat ambient temperature is provided. The aqueous composition comprises: (i) adenaturing agent selected from sodium dodecyl sulphate (SDS) or a guanidinium salt;(ii) aurintricarboxylic acid (ATA); and (iii) at least one of a chelating agent and abuffering agent; wherein the composition has a pH of 4.9 or less. A method ofstabilizing nucleic acid contained in a biological sample at ambient temperature is alsoprovided, wherein the method comprises the steps of: a) obtaining a biological sample;b) contacting the biological sample with the above-noted aqueous composition to forma mixture; c) homogenizing the mixture of (b) to form a homogeneous mixture; and d)storing the homogeneous mixture at ambient temperature.
An aqueous composition for stabilizing nucleic acid contained in a biological sampleat ambient temperature is provided. The aqueous composition comprises: (i) adenaturing agent selected from sodium dodecyl sulphate (SDS) or a guanidinium salt;(ii) aurintricarboxylic acid (ATA); and (iii) at least one of a chelating agent and abuffering agent; wherein the composition has a pH of 4.9 or less. A method ofstabilizing nucleic acid contained in a biological sample at ambient temperature is alsoprovided, wherein the method comprises the steps of: a) obtaining a biological sample;b) contacting the biological sample with the above-noted aqueous composition to forma mixture; c) homogenizing the mixture of (b) to form a homogeneous mixture; and d)storing the homogeneous mixture at ambient temperature.
The invention relates to a direct sample collection pad for assay diagnosis of a sample without introducing an additional sampling device into the assay method. This simplifies the system and method of sample collection and assay diagnosis, thus reducing waste and potential for patient irritation or injury during diagnosis.
An oral fluid collection device includes a plunger and funnel to simultaneously collect and split a single specimen into metered doses for drug testing. The device may be used with collection tubes for collection of the metered doses and later testing. The device, when used, drives the metered dose into the collection tubes and removes bubbles in the specimen to provide improved accuracy in testing.
A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
B01L 99/00 - Matière non prévue dans les autres groupes de la présente sous-classe
The invention relates to a direct sample collection pad for assay diagnosis of a sample without introducing an additional sampling device into the assay method. This simplifies the system and method of sample collection and assay diagnosis, thus reducing waste and potential for patient irritation or injury during diagnosis.
An oral fluid collection device includes a plunger and funnel to simultaneously collect and split a single specimen into metered doses for drug testing. The device may be used with collection tubes for collection of the metered doses and later testing. The device, when used, drives the metered dose into the collection tubes and removes bubbles in the specimen to provide improved accuracy in testing.
A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
The invention relates to a direct sample collection pad for assay diagnosis of a sample without introducing an additional sampling device into the assay method. This simplifies the system and method of sample collection and assay diagnosis, thus reducing waste and potential for patient irritation or injury during diagnosis.
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
An oral fluid collection device includes a plunger and funnel to simultaneously collect and split a single specimen into metered doses for drug testing. The device may be used with collection tubes for collection of the metered doses and later testing. The device, when used, drives the metered dose into the collection tubes and removes bubbles in the specimen to provide improved accuracy in testing.
A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
The invention provides novel compounds, reagents, systems, and methods for detecting a metabolite related to a NRTI in a biological sample, and uses thereof in monitoring adherence to pre-exposure prophylaxis. Such reagents comprise NRTI derivatives, analogs, NRTI derivatives conjugates, along with antibodies directed to same, which are useful for antibody-based methods, such as a lateral flow immunoassay and other point of care devices.
A61K 47/64 - Conjugués médicament-peptide, médicament-protéine ou médicament-acide polyaminé, c.-à-d. l’agent de modification étant un peptide, une protéine ou un acide polyaminé lié par covalence ou complexé à un agent thérapeutiquement actif
C07K 16/44 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel non prévu ailleurs
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
32.
REAGENTS, METHODS, AND SYSTEMS FOR DETECTING THERAPEUTIC AGENTS TO MONITOR ADHERENCE TO NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR METABOLITES
The invention provides novel compounds, reagents, systems, and methods for detecting a metabolite related to a NRTI in a biological sample, and uses thereof in monitoring adherence to pre-exposure prophylaxis. Such reagents comprise NRTI derivatives, analogs, NRTI derivatives conjugates, along with antibodies directed to same, which are useful for antibody-based methods, such as a lateral flow immunoassay and other point of care devices.
A61K 47/64 - Conjugués médicament-peptide, médicament-protéine ou médicament-acide polyaminé, c.-à-d. l’agent de modification étant un peptide, une protéine ou un acide polyaminé lié par covalence ou complexé à un agent thérapeutiquement actif
33.
Reagents, methods, and systems for detecting therapeutic agents to monitor adherence to nucleoside reverse transcriptase inhibitor metabolites
The invention provides novel compounds, reagents, systems, and methods for detecting a metabolite related to a NRTI in a biological sample, and uses thereof in monitoring adherence to pre-exposure prophylaxis. Such reagents comprise NRTI derivatives, analogs, NRTI derivatives conjugates, along with antibodies directed to same, which are useful for antibody-based methods, such as a lateral flow immunoassay and other point of care devices.
G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
C07K 16/44 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel non prévu ailleurs
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
G01N 33/577 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet faisant intervenir des anticorps monoclonaux
The invention provides a developer solution vial and methods of its use to diagnose diseases using a sampling and/or assay device, for example, for use with a lateral flow assay (LFA) device. The developer solution vial may include any container that is capable of holding developer solution. The developer solution vial is keyed to the sampling and/or assay device. The developer solution vial minimizes the amount of developer solution required for accurate fluid flow assay testing.
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
The invention provides a developer solution vial and methods of its use to diagnose diseases using a sampling and/or assay device, for example, for use with a lateral flow assay (LFA) device. The developer solution vial may include any container that is capable of holding developer solution. The developer solution vial is keyed to the sampling and/or assay device. The developer solution vial minimizes the amount of developer solution required for accurate fluid flow assay testing.
The disclosure relates to devices, solutions and methods for collecting and processing samples of bodily fluids containing cells (as well as embodiments for the collection, and processing and/or analysis of other fluids including toxic and/or hazardous substances/fluids). In addition, the disclosure relates generally to function genomic studies and to the isolation and preservation of cells from saliva and other bodily fluids (e.g., urine), for cellular analysis. With respect to devices for collection of bodily fluids, some embodiments include two mating bodies, a cap and a tube (for example), where, in some embodiments, the cap includes a closed interior space for holding a sample preservative solution and mates with the tube to constitute the (closed) sample collection device. Upon mating, the preservation solution flows into the closed interior space to preserve cells in the bodily fluid. The tube is configured to receive a donor sample of bodily fluid (e.g., saliva, urine), which can then be subjected to processing to extract a plurality of cells. The plurality of cells can be further processed to isolate one and/or another cell type therefrom. The plurality of cells, as well as the isolated cell type(s), can be analyzed for functional genomic and epigenetic studies, as well as biomarker discovery.
A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
G01N 1/10 - Dispositifs pour prélever des échantillons à l'état liquide ou fluide
G01N 1/00 - ÉchantillonnagePréparation des éprouvettes pour la recherche
37.
Method for collecting and preserving a biological sample
The disclosure relates to devices, solutions and methods for collecting and processing samples of bodily fluids containing cells (as well as embodiments for the collection, and processing and/or analysis of other fluids including toxic and/or hazardous substances/fluids). In addition, the disclosure relates generally to function genomic studies and to the isolation and preservation of cells from saliva and other bodily fluids (e.g., urine), for cellular analysis. With respect to devices for collection of bodily fluids, some embodiments include two mating bodies, a cap and a tube (for example), where, in some embodiments, the cap includes a closed interior space for holding a sample preservative solution and mates with the tube to constitute the (closed) sample collection device. Upon mating, the preservation solution flows into the closed interior space to preserve cells in the bodily fluid. The tube is configured to receive a donor sample of bodily fluid (e.g., saliva, urine), which can then be subjected to processing to extract a plurality of cells. The plurality of cells can be further processed to isolate one and/or another cell type therefrom. The plurality of cells, as well as the isolated cell type(s), can be analyzed for functional genomic and epigenetic studies, as well as biomarker discovery.
A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
G01N 1/10 - Dispositifs pour prélever des échantillons à l'état liquide ou fluide
G01N 1/00 - ÉchantillonnagePréparation des éprouvettes pour la recherche
38.
LATERAL FLOW ASSAYS FOR DIFFERENTIAL ISOTYPE DETECTION
Disclosed are lateral flow assay methods, lateral flow assay test strips, and devices for detection of antibody classes associated with acute immune responses. The invention generally relates to assay methods, in particular, lateral flow assay methods for detection of an antibody isotype associated with acute infection, and to lateral flow assay strips for use in the methods of the invention.
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
G01N 33/553 - Support métallique ou recouvert d'un métal
G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
39.
STABILIZING COMPOSITION AND METHOD FOR PRESERVING A BODILY FLUID
An aqueous stabilizing composition for preserving a bodily fluid at ambient temperature is provided. The aqueous stabilizing composition comprises: a sugar selected from a monosaccharide, a disaccharide, or a combination thereof; a buffering agent; a C1-C6 alkanol; boric acid, a salt of boric acid, or a combination thereof; and a chelating agent; wherein the composition has a pH of from 4.5 to 5.2. A method for preserving a bodily fluid using the aqueous stabilizing composition is also provided, the method comprising: a) obtaining a sample of the bodily fluid; b) contacting the bodily fluid with the aqueous stabilizing composition to form a mixture; c) mixing the mixture of (b) to form a homogeneous mixture; and d) storing the homogeneous mixture at ambient temperature.
G01N 1/28 - Préparation d'échantillons pour l'analyse
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
C12Q 1/00 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions
G01N 1/38 - Dilution, dispersion ou mélange des échantillons
G01N 33/48 - Matériau biologique, p. ex. sang, urineHémocytomètres
A01N 1/00 - Conservation de corps humains ou animaux, ou de parties de ceux-ci
C12N 1/04 - Conservation des micro-organismes à l'état viable
40.
STABILIZING COMPOSITION AND METHOD FOR PRESERVING A BODILY FLUID
16 6 alkanol; boric acid, a salt of boric acid, or a combination thereof; and a chelating agent; wherein the composition has a pH of from 4.5 to 5.2. A method for preserving a bodily fluid using the aqueous stabilizing composition is also provided, the method comprising: a) obtaining a sample of the bodily fluid; b) contacting the bodily fluid with the aqueous stabilizing composition to form a mixture; c) mixing the mixture of (b) to form a homogeneous mixture; and d) storing the homogeneous mixture at ambient temperature.
G01N 1/28 - Préparation d'échantillons pour l'analyse
C12Q 1/00 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
G01N 1/38 - Dilution, dispersion ou mélange des échantillons
G01N 33/48 - Matériau biologique, p. ex. sang, urineHémocytomètres
A01N 1/00 - Conservation de corps humains ou animaux, ou de parties de ceux-ci
C12N 1/04 - Conservation des micro-organismes à l'état viable
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
Produits et services
(1) Preservatives for optimizing the stability of biological samples and body fluid specimens during storage and transport to testing facilities; stabilizing preparations for preserving biological samples and body fluid specimens during transportation and storage to testing facilities for medical diagnostic purposes.
Medical device for analyzing and checking adherence to prescribed medication regimens, detecting non-compliance with medical treatment plans and medication regimens, and alerting users when a non-compliance with medical adherence is detected
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Medical diagnostic rapid point-of-care test kits being specimen collection kits for use in virus testing, comprised primarily of nasal swabs for medical purposes, and also including plastic bags and boxes for oral fluid collection, as well as printed instructions for use, all for the detection of antibodies, antigen and viruses
44.
DEVICES, SOLUTIONS AND METHODS FOR SAMPLE COLLECTION
Some embodiments are directed to a bodily fluid sample collection device for the collection of naturally expressed bodily fluids and include a cap engageable with a tube to close a mouth of the tube. The cap includes a chamber for containing a reagent. The tube defines at least partly a sample collection space for receiving the naturally expressed bodily fluid. The cap comprises first and second cap portions relatively movable with respect to each other. The first and second cap portions are configured such that, responsive to engagement of the cap on the tube, one of the cap portions is caused to move integrally relative to the other cap portion to open the chamber and permit fluid communication between the chamber and the sample collection space. The reagent in the chamber is thereby permitted to mix with the bodily fluid in the sample collection space. A method of organizing and processing samples is also described.
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
B65D 51/28 - Fermetures non prévues ailleurs combinées avec dispositifs auxiliaires pour des buts autres que la fermeture avec réceptacles auxiliaires pour objets ou matériaux supplémentaires
A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
B65D 25/56 - Ouvertures ou fenêtres d'inspection avec moyens pour indiquer le niveau du contenu
B65D 41/04 - Capuchons ou couvercles en forme de capuchons filetés ou similaires, fixés par rotation
B65D 55/02 - Dispositifs de blocageMoyens pour empêcher ou indiquer l'ouverture ou l'enlèvement de la fermeture non autorisés
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Medical diagnostic rapid point-of-care test kits being specimen collection kits for use in virus testing, comprised primarily of nasal swabs for medical purposes, and also including plastic bags and boxes for oral fluid collection, as well as printed instructions for use, all for the detection of antibodies, antigen and viruses
Disclosed herein are assay methods, lateral flow assay test strips, and devices for improved analyte detection. Analyte binding to target is performed both in solution phase and with a target immobilized on a surface, resulting in improved analyte detection.
G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
G01N 33/536 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec formation d'un complexe immunologique en phase liquide
G01N 33/558 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet utilisant la diffusion ou la migration de l'anticorps ou de l'antigène
47.
Composition, system and method for removal of detergents from aqueous solutions
where R1 is an optionally substituted, linear, branched or cyclic C4-C12 alkyl; and a water immiscible halocarbon, wherein said halocarbon is miscible with said alcohol of Formula I. The system can be used on aqueous solutions that contain detergents (such as Sodium Dodecyl Sulphate (SDS), for example), and any detergent-associated or detergent-bound molecules that may be present in the aqueous solution, to form an aqueous phase and a non-aqueous phase, for effectively removing the detergent and any detergent-associated or detergent-bound molecules, and sequestering them into the non-aqueous phase.
The disclosure relates to devices, solutions and methods for collecting and processing samples of bodily fluids containing cells (as well as embodiments for the collection, and processing and/or analysis of other fluids including toxic and/or hazardous substances/fluids). In addition, the disclosure relates generally to function genomic studies and to the isolation and preservation of cells from saliva and other bodily fluids (e.g., urine), for cellular analysis. With respect to devices for collection of bodily fluids, some embodiments include two mating bodies, a cap and a tube (for example), where, in some embodiments, the cap includes a closed interior space for holding a sample preservative solution and mates with the tube to constitute the (closed) sample collection device. Upon mating, the preservation solution flows into the closed interior space to preserve cells in the bodily fluid. The tube is configured to receive a donor sample of bodily fluid (e.g., saliva, urine), which can then be subjected to processing to extract a plurality of cells. The plurality of cells can be further processed to isolate one and/or another cell type therefrom. The plurality of cells, as well as the isolated cell type(s), can be analyzed for functional genomic and epigenetic studies, as well as biomarker discovery.
A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
G01N 1/10 - Dispositifs pour prélever des échantillons à l'état liquide ou fluide
G01N 1/00 - ÉchantillonnagePréparation des éprouvettes pour la recherche
49.
Products and methods for monitoring adherence to nucleoside reverse transcriptase inhibitor therapy
The invention provides novel compounds, reagents, systems, and methods for detecting a metabolite related to a NRTI in a biological sample, and use thereof in monitoring adherence to pre-exposure prophylaxis or anti-retroviral treatment. Such reagents comprise NRTI derivatives, analogs, NRTI derivatives conjugates, along with antibodies directed to same, which are useful for anti-body-based methods, such as a lateral flow immunoassay and other point of care devices.
C07K 16/44 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel non prévu ailleurs
G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
C07F 9/6561 - Composés hétérocycliques, p. ex. contenant du phosphore comme hétéro-atome du cycle contenant des systèmes de plusieurs hétérocycles déterminants condensés entre eux ou condensés avec un carbocycle ou un système carbocyclique commun, avec ou sans autres hétérocycles non condensés
A61K 47/64 - Conjugués médicament-peptide, médicament-protéine ou médicament-acide polyaminé, c.-à-d. l’agent de modification étant un peptide, une protéine ou un acide polyaminé lié par covalence ou complexé à un agent thérapeutiquement actif
50.
Composition and method for stabilizing nucleic acids in biological samples
Methods, compositions, and kits for stabilizing both human and microbial deoxyribonucleic acid (DNA) present in complex biological samples, such as feces, are disclosed. In particular, aqueous compositions for stabilizing DNA contained in biological samples at ambient temperature are disclosed, together with associated methods and kits using same. In one aspect, the compositions comprise a chelating agent present at a concentration of at least about 150 mM, and the composition has a pH of at least about 9.5.
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
A61K 31/711 - Acides désoxyribonucléiques naturels, c.-à-d. contenant uniquement des 2'-désoxyriboses liés à l'adénine, la guanine, la cytosine ou la thymine et ayant des liaisons 3'-5' phosphodiester
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
Disclosed are lateral flow assay methods, lateral flow assay test strips, and devices for detection of antibody classes associated with acute immune responses. The invention generally relates to assay methods, in particular, lateral flow assay methods for detection of an antibody isotype associated with acute infection, and to lateral flow assay strips for use in the methods of the invention.
G01N 33/564 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour complexes immunologiques préexistants ou maladies auto-immunes
C07K 14/18 - Togaviridae, p. ex. flavivirus, virus de la peste, virus de la fièvre jaune, virus de l'hépatite C, virus de l'encéphalite japonaise
C07K 16/00 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux
C07K 16/10 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus de virus à ARN
C07K 1/22 - Chromatographie d'affinité ou techniques analogues basées sur des procédés d'absorption sélective
53.
LATERAL FLOW ASSAYS FOR DIFFERENTIAL ISOTYPE DETECTION
Disclosed are lateral flow assay methods, lateral flow assay test strips, and devices for detection of antibody classes associated with acute immune responses. The invention generally relates to assay methods, in particular, lateral flow assay methods for detection of an antibody isotype associated with acute infection, and to lateral flow assay strips for use in the methods of the invention.
C07K 16/10 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus de virus à ARN
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Reagents for scientific and research purposes used to collect, stabilize, transport and prepare analytes (nucleic acids, proteins, metabolites) from environmental samples, swabbed from surfaces, or sourced from blood, saliva, tissue, skin, urine, feces, sputum, and other bodily fluids; Kits comprising a preserving solution and specially designed collection tube used to optimally collect, stabilize, preserve, transport and extract analytes (nucleic acids, proteins, metabolites) from environmental samples, swabbed from surfaces, or sourced from blood, saliva, tissue, skin, urine, feces, sputum and other bodily fluids extracted or collected from humans and animals. Reagents for clinical, medical and medical diagnostic use used to collect, stabilize, transport and prepare analytes (nucleic acids, proteins, metabolites) from environmental samples, swabbed from surfaces, or sourced from blood, saliva, tissue, skin, urine, feces, sputum, and other bodily fluids; Kits comprising a preserving solution and specially designed collection tube used to optimally collect, stabilize, preserve, transport and extract analytes (nucleic acids, proteins, metabolites) from environmental samples, swabbed from surfaces, or sourced from blood, saliva, tissue, skin, urine, feces, sputum and other bodily fluids extracted or collected from humans and animals. Scientific research, namely identification and testing of analytes (nucleic acids, proteins, metabolites) from environmental samples, swabbed from surfaces, or sourced from blood, saliva, tissue, urine, feces, sputum, and other bodily fluids extracted or collected from humans and animals; scientific research and development in the field of multi-omics, including analytes (nucleic acids, proteins, metabolites) testing, purification and extraction from blood, saliva, tissue, skin, urine, feces, sputum, and other bodily fluids extracted or collected from humans and animals; laboratory services.
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
Scientific research kits for metabolites sample collection, stabilization, transportation and preparation consisting primarily of a preserving solution and specially designed collection receptacle to collect multiple sample types, including but not limited to saliva, urine, feces, tissue, sputum or blood. Diagnostic kits for metabolites sample collection, stabilization, transportation and preparation consisting primarily of a specifically designed collection receptacle containing a preserving solution to collect multiple sample types, including but not limited to saliva, urine, feces, tissue, sputum or blood.
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Genetic testing for medical, clinical, and diagnostic purposes of analytes (nucleic acids, proteins, metabolites) from environmental samples, swabbed from surfaces, or sourced from blood, saliva, tissue, urine, feces, sputum, and other bodily fluids extracted or collected from humans and animals
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Reagents used to collect, stabilize, transport and prepare analytes (nucleic acids, proteins, metabolites) from environmental samples, swabbed from surfaces, or sourced from blood, saliva, tissue, skin, urine, feces, sputum, and other bodily fluids; Kits comprising a preserving solution and specially designed collection tube used to optimally collect, stabilize, preserve, transport and extract analytes (nucleic acids, proteins, metabolites) from environmental samples, swabbed from surfaces, or sourced from blood, saliva, tissue, skin, urine, feces, sputum and other bodily fluids extracted or collected from humans and animals all of the foregoing for scientific and research purposes Reagents used to collect, stabilize, transport and prepare analytes (nucleic acids, proteins, metabolites) from environmental samples, swabbed from surfaces, or sourced from blood, saliva, tissue, skin, urine, feces, sputum, and other bodily fluids; Kits comprising a preserving solution and specially designed collection tube used to optimally collect, stabilize, preserve, transport and extract analytes (nucleic acids, proteins, metabolites) from environmental samples, swabbed from surfaces, or sourced from blood, saliva, tissue, skin, urine, feces, sputum and other bodily fluids extracted or collected from humans and animals all of the foregoing for clinical, medical and medical diagnostic use Genetic testing for scientific and research purposes of analytes (nucleic acids, proteins, metabolites) from environmental samples, swabbed from surfaces, or sourced from blood, saliva, tissue, urine, feces, sputum, and other bodily fluids extracted or collected from humans and animals; scientific and medical research and development in the field of multi-omics, including analyte (nucleic acids, proteins, metabolites) testing, purification and extraction from blood, saliva, tissue, skin urine, feces, sputum, and other bodily fluids extracted or collected from humans and animals; laboratory services for medical, scientific, and research purposes
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
10 - Appareils et instruments médicaux
Produits et services
Scientific research kits for metabolites sample collection, stabilization, transportation and preparation consisting primarily of a preserving solution and specially designed collection receptacle to college multiple sample types, including but not limited to saliva, urine, feces, tissue, sputum or blood Diagnostic kits for metabolites sample collection, stabilization, transportation and preparation consisting primarily of a specifically designed collection receptacle and also containing a preserving solution and specially designed collection receptacle to collect multiple sample types, including but not limited to saliva, urine, feces, tissue, sputum or blood
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
(1) Reagents for scientific and research purposes used to collect, stabilize, transport and prepare analytes (namely, nucleic acids, proteins, metabolites) obtained from environmental samples, swabbed from surfaces, or sourced from blood, saliva, tissue, skin, urine, feces, sputum, and other bodily fluids extracted or collected from humans and animals; Kits comprising a preserving solution and specially designed collection tube used to optimally collect, stabilize, preserve, transport and extract analytes (nucleic acids, proteins, metabolites) from environmental samples, swabbed from surfaces, or sourced from blood, saliva, tissue, skin, urine, feces, sputum and other bodily fluids extracted or collected from humans and animals all of the foregoing for scientific and research purposes.
(2) Reagents for clinical, medical and medical diagnostic purposes used to collect, stabilize, transport and prepare analytes (namely nucleic acids, proteins, metabolites) obtained from environmental samples, swabbed from surfaces, or sourced from blood, saliva, tissue, skin, urine, feces, sputum, and other bodily fluids extracted or collected from humans and animals; Kits comprising a preserving solution and specially designed collection tube used to optimally collect, stabilize, preserve, transport and extract analytes (nucleic acids, proteins, metabolites) from environmental samples, swabbed from surfaces, or sourced from blood, saliva, tissue, skin, urine, feces, sputum and other bodily fluids extracted or collected from humans and animals all of the foregoing for clinical, medical and medical diagnostic use. (1) Identification and testing of analytes (nucleic acids, proteins, metabolites) from environmental samples, swabbed from surfaces, or sourced from blood, saliva, tissue, urine, feces, sputum, and other bodily fluids extracted or collected from humans and animals; research and development in the field of multi-omics, including analyte (nucleic acids, proteins, metabolites) testing, purification and extraction from blood, saliva, tissue, skin urine, feces, sputum, and other bodily fluids extracted or collected from humans and animals; laboratory services namely laboratory testing of materials, laboratory research services in the field of multiomics, including analyte (nucleic acids, proteins, metabolites) testing, purification and extraction from blood, saliva, tissue, skin urine, feces, sputum, and other bodily fluids extracted or collected from humans and animals, clinical laboratory research studies, medical research laboratory services and medical diagnostic laboratory services.
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
(1) Scientific research kits for collecting, stabilizing, transporting and preparing samples for metabolite analysis which kits comprise of a preservative and specially designed collection receptacle to collect saliva, urine, feces, tissue, sputum, skin, nasal, vaginal and blood samples.
(2) Diagnostic kits for collecting, stabilizing, transporting and preparing samples for metabolite analysis which kits comprise a specifically designed collection receptacle, a preservative and specially designed collection receptacle to collect saliva, urine, feces, tissue, sputum, skin, nasal, vaginal and blood samples.
61.
CONTAINER SYSTEM FOR RELEASABLY STORING A SUBSTANCE
The present invention provides a container system for releasably storing a substance. The container system includes a vial having a sample storage chamber and a piercing member for piercing a membrane in the lid, which membrane seals a substance within a reservoir in the lid until the membrane is pierced by the piercing member. The container system optionally includes a funnel. There is also provided a method and kit for use of such a container system.
B65D 51/28 - Fermetures non prévues ailleurs combinées avec dispositifs auxiliaires pour des buts autres que la fermeture avec réceptacles auxiliaires pour objets ou matériaux supplémentaires
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
Disclosed herein are assay methods, lateral flow assay test strips, and devices for improved analyte detection. Analyte binding to target is performed both in solution phase and with a target immobilized on a surface, resulting in improved analyte detection.
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
C07K 16/10 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus de virus à ARN
G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
Disclosed herein are assay methods, lateral flow assay test strips, and devices for improved analyte detection. Analyte binding to target is performed both in solution phase and with a target immobilized on a surface, resulting in improved analyte detection.
C07K 16/10 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus de virus à ARN
G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
G01N 33/536 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec formation d'un complexe immunologique en phase liquide
65.
Stabilizing compositions and methods for extraction of ribonucleic acid
The present invention provides a composition and method for stabilizing ribonucleic acid (RNA) from biological samples such that the ribonucleic acid within the sample remains stable at room temperature. The composition comprises an anionic detergent and a buffering agent at a pH of about 5 to about 8.2 and is used in methods for extracting and storing ribonucleic acid from the biological sample.
The disclosure relates to devices, solutions and methods for collecting and processing samples of bodily fluids containing cells (as well as embodiments for the collection, and processing and/or analysis of other fluids including toxic and/or hazardous substances/fluids). In addition, the disclosure relates generally to function genomic studies and to the isolation and preservation of cells from saliva and other bodily fluids (e.g., urine), for cellular analysis. With respect to devices for collection of bodily fluids, some embodiments include two mating bodies, a cap and a tube (for example), where, in some embodiments, the cap includes a closed interior space for holding a sample preservative solution and mates with the tube to constitute the (closed) sample collection device. Upon mating, the preservation solution flows into the closed interior space to preserve cells in the bodily fluid. The tube is configured to receive a donor sample of bodily fluid (e.g., saliva, urine), which can then be subjected to processing to extract a plurality of cells. The plurality of cells can be further processed to isolate one and/or another cell type therefrom. The plurality of cells, as well as the isolated cell type(s), can be analyzed for functional genomic and epigenetic studies, as well as biomarker discovery.
A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
G01N 1/10 - Dispositifs pour prélever des échantillons à l'état liquide ou fluide
G01N 1/00 - ÉchantillonnagePréparation des éprouvettes pour la recherche
67.
Devices, solutions and methods for sample collection related applications, analysis and diagnosis
A solution is described for preserving cells and/or extra-cellular components in naturally expressed bodily fluids (e.g. saliva, sputum, urine) for further downstream analysis and/or for diagnosis of a medical condition. The solution may be hypertonic with respect to blood. Techniques are described for enriching cells from a sample of a naturally expressed bodily fluid, and/or for analysis, e.g. to diagnose medical conditions such as cancer, obesity, infections, autism, Alzheimer disease, hetotological disorders, cardiovascular disease or disorders, diabetes, vulnerable plack, LTBI, HIV infection, COPD, ACQS.
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
68.
A COMPOSITION, SYSTEM AND METHOD FOR REMOVAL OF DETERGENTS FROM AQUEOUS SOLUTIONS
The present application provides a system, composition, method and kit for removing a detergent, such as an anionic detergent, from an aqueous solution, comprising a salt, a water immiscible alcohol of Formula I: R1 - OH (Formula I) where R1 is an optionally substituted, linear, branched or cyclic C4 - C12 alkyl; and a water immiscible halocarbon, wherein said halocarbon is miscible with said alcohol of Formula I. The system can be used on aqueous solutions that contain detergents (such as Sodium Dodecyl Sulphate (SDS), for example), and any detergent-associated or detergent-bound molecules that may be present in the aqueous solution, to form an aqueous phase and a non-aqueous phase, for effectively removing the detergent and any detergent-associated or detergent-bound molecules, and sequestering them into the non- aqueous phase. The present composition, system, method and kit may, thus, ideally be used to remove inhibitors from aqueous solutions, i.e., inhibitors that inhibit reactions such as downstream applications including, but not limited to, Polymerase Chain Reaction (PCR, including Reverse Transcriptase-PCR (RT-PCR)), library preparation, and nucleotide sequencing. The aqueous phase may then be used directly for these downstream applications.
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
B01D 17/00 - Séparation de liquides, non prévue ailleurs, p. ex. par diffusion thermique
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
The present application provides a system, composition, method and kit for removing a detergent, such as an anionic detergent, from an aqueous solution, comprising a salt, a water immiscible alcohol of Formula I: R1 – OH (Formula I) where R1 is an optionally substituted, linear, branched or cyclic C4 - C12 alkyl; and a water immiscible halocarbon, wherein said halocarbon is miscible with said alcohol of Formula I. The system can be used on aqueous solutions that contain detergents (such as Sodium Dodecyl Sulphate (SDS), for example), and any detergent-associated or detergent-bound molecules that may be present in the aqueous solution, to form an aqueous phase and a non-aqueous phase, for effectively removing the detergent and any detergent-associated or detergent-bound molecules, and sequestering them into the non- aqueous phase. The present composition, system, method and kit may, thus, ideally be used to remove inhibitors from aqueous solutions, i.e., inhibitors that inhibit reactions such as downstream applications including, but not limited to, Polymerase Chain Reaction (PCR, including Reverse Transcriptase-PCR (RT-PCR)), library preparation, and nucleotide sequencing. The aqueous phase may then be used directly for these downstream applications.
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
B01D 17/00 - Séparation de liquides, non prévue ailleurs, p. ex. par diffusion thermique
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
Clostridium difficile, in a biological sample, comprising contacting the biological sample with a stabilization composition, wherein the stabilization composition comprises a chelating agent, a denaturing, a salt and has a pH between about 6 and about 11.
C12Q 1/24 - Méthodes d'échantillonnage, d'inoculation ou de développement d'un échantillonMéthodes pour isoler physiquement un micro-organisme intact
C12Q 1/00 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions
71.
Composition and method for stabilizing nucleic acids in biological samples
Methods, compositions, and kits for stabilizing both human and microbial deoxyribonucleic acid (DNA) present in complex biological samples, such as feces, are disclosed. In particular, aqueous compositions for stabilizing DNA contained in biological samples at ambient temperature are disclosed, together with associated methods and kits using same. In one aspect, the compositions comprise a chelating agent present at a concentration of at least about 150 mM, and the composition has a pH of at least about 9.5.
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
A61K 31/711 - Acides désoxyribonucléiques naturels, c.-à-d. contenant uniquement des 2'-désoxyriboses liés à l'adénine, la guanine, la cytosine ou la thymine et ayant des liaisons 3'-5' phosphodiester
72.
Method and system for microbial lysis using periodates
Some embodiments are directed to a bodily fluid sample collection device for the collection of naturally expressed bodily fluids and include a cap engageable with a tube to close a mouth of the tube. The cap includes a chamber for containing a reagent. The tube defines at least partly a sample collection space for receiving the naturally expressed bodily fluid. The cap comprises first and second cap portions relatively movable with respect to each other. The first and second cap portions are configured such that, responsive to engagement of the cap on the tube, one of the cap portions is caused to move integrally relative to the other cap portion to open the chamber and permit fluid communication between the chamber and the sample collection space. The reagent in the chamber is thereby permitted to mix with the bodily fluid in the sample collection space. A method of organizing and processing samples is also described.
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
B65D 51/28 - Fermetures non prévues ailleurs combinées avec dispositifs auxiliaires pour des buts autres que la fermeture avec réceptacles auxiliaires pour objets ou matériaux supplémentaires
A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
B65D 25/56 - Ouvertures ou fenêtres d'inspection avec moyens pour indiquer le niveau du contenu
B65D 41/04 - Capuchons ou couvercles en forme de capuchons filetés ou similaires, fixés par rotation
B65D 55/02 - Dispositifs de blocageMoyens pour empêcher ou indiquer l'ouverture ou l'enlèvement de la fermeture non autorisés
74.
Stabilizing compositions and methods for extraction of ribonucleic acid
The present invention provides a composition and method for stabilizing ribonucleic acid (RNA) from biological samples such that the ribonucleic acid within the sample remains stable at room temperature. The composition comprises an anionic detergent and a buffering agent at a pH of about 5 to about 8.2 and is used in methods for extracting and storing ribonucleic acid from the biological sample.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
75.
COMPOSITION AND METHOD FOR STABILIZING AND MAINTAINING THE VIABILITY OF HARDY MICROORGANISMS
The present application is to provide a composition and method for stabilizing and maintaining the viability of hardy microorganisms from sample collection to downstream analysis. In particular, there is a method for preserving viable hardy bacteria, such as Mycobacteria, Bacillus anthracis, or Clostridium difficile, in a biological sample, comprising contacting the biological sample with a stabilization composition, wherein the stabilization composition comprises a chelating agent, a denaturing, a salt and has a p H between about 6 and about 11.
C12Q 1/00 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions
76.
COMPOSITION AND METHOD FOR STABILIZING AND MAINTAINING THE VIABILITY OF HARDY MICROORGANISMS
The present application is to provide a composition and method for stabilizing and maintaining the viability of hardy microorganisms from sample collection to downstream analysis. In particular, there is a method for preserving viable hardy bacteria, such as Mycobacteria, Bacillus anthracis, or Clostridium difficile, in a biological sample, comprising contacting the biological sample with a stabilization composition, wherein the stabilization composition comprises a chelating agent, a denaturing, a salt and has a p H between about 6 and about 11.
C12Q 1/00 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
77.
DEVICE FOR COLLECTING, TRANSPORTING AND STORING BIOMOLECULES FROM A BIOLOGICAL SAMPLE
The present application provides a sample receiving device comprising a vial, a receptacle in communication with the vial for receiving the sample, and a cap comprising a pusher, the pusher for engaging with the sample in the receptacle. The receptacle comprises a disrupting means for disrupting the sample when the pusher engages with the sample in the receptacle and expels the disrupted sample into the vial. Typically, the device can be used for collecting fecal samples. A method of preserving a biomolecule in the device using a biomolecule preserving composition is also provided.
G01N 1/38 - Dilution, dispersion ou mélange des échantillons
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
C12M 1/24 - Appareillage pour l'enzymologie ou la microbiologie en forme de tube ou de bouteille
C12M 1/28 - Inoculateur ou échantillonneur incorporé au récipient
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
C12Q 1/00 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
78.
DEVICE FOR COLLECTING, TRANSPORTING AND STORING BIOMOLECULES FROM A BIOLOGICAL SAMPLE
The present application provides a sample receiving device comprising a vial, a receptacle in communication with the vial for receiving the sample, and a cap comprising a pusher, the pusher for engaging with the sample in the receptacle. The receptacle comprises a disrupting means for disrupting the sample when the pusher engages with the sample in the receptacle and expels the disrupted sample into the vial. Typically, the device can be used for collecting fecal samples. A method of preserving a biomolecule in the device using a biomolecule preserving composition is also provided.
G01N 1/38 - Dilution, dispersion ou mélange des échantillons
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
C12M 1/24 - Appareillage pour l'enzymologie ou la microbiologie en forme de tube ou de bouteille
C12M 1/28 - Inoculateur ou échantillonneur incorporé au récipient
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
C12Q 1/00 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
The present application provides a composition comprising periodates or persulfates for extracting nucleic acid from a microorganism, and a corresponding method of using the composition for nucleic acid extraction. The composition and method are particularly useful in extracting nucleic acid from microorganisms that are generally resistant to standard nucleic extraction techniques, such as, one or more species of the Mycobacterium genus, one or more species of the M. tuberculosis complex, MDR strains of M. tuberculosis, one or more species of Clostridium, one or more species of Bacillus, and other microorganisms with hardy cell walls.
The present application provides a composition comprising periodates or persulfates for extracting nucleic acid from a microorganism, and a corresponding method of using the composition for nucleic acid extraction. The composition and method are particularly useful in extracting nucleic acid from microorganisms that are generally resistant to standard nucleic extraction techniques, such as, one or more species of the Mycobacterium genus, one or more species of the M. tuberculosis complex, MDR strains of M. tuberculosis, one or more species of Clostridium, one or more species of Bacillus, and other microorganisms with hardy cell walls.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
83.
COMPOSITION AND METHOD FOR STABILIZING NUCLEIC ACIDS IN BIOLOGICAL SAMPLES
Methods, compositions, and kits for stabilizing both human and microbial deoxyribonucleic acid (DNA) present in complex biological samples, such as feces, are disclosed. In particular, aqueous compositions for stabilizing DNA contained in biological samples at ambient temperature are disclosed, together with associated methods and kits using same. In one aspect, the compositions comprise a chelating agent present at a concentration of at least about 150 m M, and the composition has a pH of at least about 9.5.
Methods, compositions, and kits for stabilizing both human and microbial deoxyribonucleic acid (DNA) present in complex biological samples, such as feces, are disclosed. In particular, aqueous compositions for stabilizing DNA contained in biological samples at ambient temperature are disclosed, together with associated methods and kits using same. In one aspect, the compositions comprise a chelating agent present at a concentration of at least about 150 m M, and the composition has a pH of at least about 9.5.
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
85.
METHOD AND COMPOSITION FOR NUCLEIC ACID STORAGE FROM BLOOD FRACTIONS
The present application provides a method and aqueous composition for stabilizing and isolating nucleic acid from whole blood or blood fraction samples. The method and aqueous composition can be used to stabilize and isolate nucleic acid from whole blood, plasma, buffy coat or total white blood cell isolates. The aqueous composition can comprise a denaturing agent, a chelating agent and a buffering agent, preferably in the absence of a chaotrope, and at a pH greater than 5.0. The samples can be stored at varying temperatures, preferably at room temperature, and for prolonged lengths of time while maintaining integrity of the nucleic acid.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
The disclosure relates to devices, solutions and methods for collecting and processing samples of bodily fluids containing cells (as well as embodiments for the collection, and processing and/or analysis of other fluids including toxic and/or hazardous substances/fluids). In addition, the disclosure relates generally to function genomic studies and to the isolation and preservation of cells from saliva and other bodily fluids (e.g., urine), for cellular analysis. With respect to devices for collection of bodily fluids, some embodiments include two mating bodies, a cap and a tube (for example), where, in some embodiments, the cap includes a closed interior space for holding a sample preservative solution and mates with the tube to constitute the (closed) sample collection device. Upon mating, the preservation solution flows into the closed interior space to preserve cells in the bodily fluid. The tube is configured to receive a donor sample of bodily fluid (e.g., saliva, urine), which can then be subjected to processing to extract a plurality of cells. The plurality of cells can be further processed to isolate one and/or another cell type therefrom. The plurality of cells, as well as the isolated cell type(s), can be analyzed for functional genomic and epigenetic studies, as well as biomarker discovery.
G01N 33/00 - Recherche ou analyse des matériaux par des méthodes spécifiques non couvertes par les groupes
G01N 1/10 - Dispositifs pour prélever des échantillons à l'état liquide ou fluide
A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
G01N 1/00 - ÉchantillonnagePréparation des éprouvettes pour la recherche
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Medical diagnostic test kit comprised of diagnostic preparation for detection of drugs in the body; medical diagnostic saliva pads; medical diagnostic saliva vials.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Medical diagnostic test kit comprised of diagnostic preparation for detection of drugs in the body; medical diagnostic saliva pads; medical diagnostic saliva vials.
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Kits use to collect, preserve and transport DNA samples from subjects' saliva for identification and testing purposes comprising a preserving solution and a specially designed collection tube. Kits use to collect, preserve and transport DNA samples from subjects' saliva for identification and testing purposes comprising a preserving solution and a specially designed collection tube. Identification and testing of DNA samples sourced from saliva for the forensic and law enforcement, military, research, medical, veterinary and consumer markets.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Reagents for scientific purposes, amongst others reagents used to collect, stabilize, transport and/or prepare nucleic acids extracted from whole blood and blood derivatives. Chemical reagents for medical or veterinary purposes. Advisory services relating to chemical reagents.
A sample collection tool comprises a collection end configured for collecting a sample. Optionally, the sample is collected from within a body cavity of an animal without causing significant discomfort or injury to the animal. A first handle portion has a first end connected to the collection end and a second end. A second handle portion is connected to the second end of the first handle portion by a breakable connection. The second end of the first handle portion has at least one winglet. The at least one winglet is compliant in a preferential direction. The breakable connection is ruptured at least in part when the at least one winglet is forced in the preferential direction.
A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
A61B 10/02 - Instruments pour prélever des échantillons cellulaires ou pour la biopsie
G01N 1/02 - Dispositifs pour prélever des échantillons
98.
Container system for releasably storing a substance
The present invention provides a container system for releasably storing a substance. The container system includes a vial having a sample storage chamber and a piercing member for piercing a membrane in the lid, which membrane seals a substance within a reservoir in the lid until the membrane is pierced by the piercing member. The container system optionally includes a funnel. There is also provided a method and kit for use of such a container system.
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
B65D 51/28 - Fermetures non prévues ailleurs combinées avec dispositifs auxiliaires pour des buts autres que la fermeture avec réceptacles auxiliaires pour objets ou matériaux supplémentaires
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
A sample collection kit includes a sample collector, a polycarbonate container, and a preservative solution. The sample collector includes an absorbent pad with a collecting element that receives a sample of oral fluid. The absorbent pad also includes an interior portion that extends into a handle. The handle includes an upper casing and a lower casing. The collecting element can be treated with a surfactant to optimize recovery of analytes from the oral sample and/or their absorbance onto the absorbent pad. A polycarbonate container receives the absorbent pad or the sample collector and stores it for testing of analytes. A dextran sulfate preservative solution is included in the polycarbonate container that inhibits enzymatic activity on a collected sample.
The disclosure relates to devices, solutions and methods for collecting and processing samples of bodily fluids containing cells (as well as embodiments for the collection, and processing and/or analysis of other fluids including toxic and/or hazardous substances/fluids). In addition, the disclosure relates generally to function genomic studies and to the isolation and preservation of cells from saliva and other bodily fluids (e.g., urine), for cellular analysis. With respect to devices for collection of bodily fluids, some embodiments include two mating bodies, a cap and a tube (for example), where, in some embodiments, the cap includes a closed interior space for holding a sample preservative solution and mates with the tube to constitute the (closed) sample collection device. Upon mating, the preservation solution flows into the closed interior space to preserve cells in the bodily fluid. The tube is configured to receive a donor sample of bodily fluid (e.g., saliva, urine), which can then be subjected to processing to extract a plurality of cells. The plurality of cells can be further processed to isolate one and/or another cell type therefrom. The plurality of cells, as well as the isolated cell type(s), can be analyzed for functional genomic and epigenetic studies, as well as biomarker discovery.
C12M 1/24 - Appareillage pour l'enzymologie ou la microbiologie en forme de tube ou de bouteille
G01N 1/10 - Dispositifs pour prélever des échantillons à l'état liquide ou fluide
G01N 33/48 - Matériau biologique, p. ex. sang, urineHémocytomètres
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
