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2025
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Invention
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N,n-diisopropylbenzamide salts. SHN,NN,N-diisopropylbenzamide, Atropisomer A-2; corresponding pha... |
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Invention
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Processes for the preparation of 4-{8-amino-3-[(2s)-1-(but-2-ynoyl)-pyrrolidin-2-yl]imidazo[1,5-a... |
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Invention
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Methods of treating chronic lymphocytic leukemia and small lymphocytic leukemia using a btk inhib... |
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Invention
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1-h-pyrrolo[2,3-c]pyridine compounds. Compounds having the structure of Formula (I):
4, and A ar... |
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2024
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Invention
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Methods of treating cancers, immune and autoimmune diseases, and inflammatory diseases based on b... |
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Invention
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Processes for the preparation of 4-{8-amino-3-[(2s)-1-(but-2-ynoyl)-pyrrolidin-2-yljimidazo[1,5-a... |
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Invention
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Therapeutic combinations of a btk inhibitor, a pi3k inhibitor, a jak-2 inhibitor, and/or a bcl-2 ... |
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Invention
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1-h-pyrrolo[2,3-c]pyridine compounds.
Compounds having the structure of Formula (I):
Compounds... |
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Invention
|
1-h-pyrrolo[2,3-c]pyridine compounds acting against cancer via agonism of menin |
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Invention
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1-h-pyrrolo[2,3-c]pyridine compounds acting against cancer via agonism of menin. Compounds having... |
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2023
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Invention
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Btk inhibitors to treat solid tumors through modulation of the tumor microenvironment.
In certai... |
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Invention
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Therapeutic combinations of a cd19 inhibitor and a btk inhibitor.
Therapeutic combinations of a ... |
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Invention
|
Crystal forms of (s)-4-(8-amino-3-(1-(but-2-ynoyl)-pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-n-... |
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|
Invention
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Methods and compositions for use of therapeutic t cells in combination with kinase inhibitors.
T... |
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2022
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Invention
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Crystal forms of (s)-4-(8-amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-n-(... |
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2021
|
Invention
|
Acalabrutinib maleate dosage forms.
The present disclosure relates, in general, to: (a) solid ph... |
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Invention
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Acalabrutinib maleate dosage forms. The present disclosure relates, in general, to: (a) solid pha... |
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2020
|
Invention
|
Imidazopyrazine inhibitors of bruton's tyrosine kinase. In some embodiments, the invention relate... |
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2019
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Invention
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Therapeutic combinations of an antifolate and a btk inhibitor.
Therapeutic combinations of an an... |
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Invention
|
Imidazopyrazine inhibitors of interleukin-2-inducible t-cell kinase. In some embodiments, the inv... |
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Invention
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Therapeutic combination of a pi3k inhibitor and a btk inhibitor.
In some embodiments, the invent... |
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Invention
|
Therapeutic combinations of a mek inhibitor and a btk inhibitor. Therapeutic combinations of a ME... |
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Invention
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Therapeutic combinations of an irak4 inhibitor and a btk inhibitor.
Therapeutic combinations of ... |
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Invention
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Therapeutic combinations of a btk inhibitor, a pi3k inhibitor, a jak-2 inhibitor, a pd-1 inhibito... |
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Invention
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Methods of blocking the cxcr-4/sdf-1 signaling pathway with inhibitors of bruton's tyrosine kinas... |
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2018
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Invention
|
Therapeutic combinations of a proteasome inhibitor and a btk inhibitor.
Therapeutic combinations... |
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Invention
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Pharmaceutical composition comprising a crystal form of (s)-4-(8-amino-3-(1-(but-2-ynoyl)pyrrolid... |
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Invention
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Methods of using btk inhibitors to treat dermatoses.
In certain embodiments, the invention inclu... |
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2017
|
Invention
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Methods and compositions for use of therapeutic t cells in combination with kinase inhibitors. Th... |
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2016
|
Invention
|
Therapeutic combinations of a btk inhibitor and a gitr binding molecule, a 4-1bb agonist, or an o... |
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Invention
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Therapeutic combinations of a mek inhibitor and a btk inhibitor.
Therapeutic combinations of a M... |
