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2009
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Invention
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Specific kinase inhibitors.
Resorcylic acid lactones having a C5-C6 cis double bond and a ketone... |
|
|
Invention
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17-allylamino-17-demethoxygeldanamycin polymorphs and formulations. Novel polymorphs and pharmace... |
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2008
|
Invention
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Intermediates and methods for the preparation of epothilones. Highly efficient methods are provid... |
|
|
Invention
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Trans-9,10-dehydroepothilone c and d, analogs thereof and methods of making the same.
The presen... |
|
|
Invention
|
Discodermolide analogues and methods of their use. 6- and 7-substituted coumarin and related 6- a... |
|
|
Invention
|
Benzoquinone ansamycins.
The invention relates to benzoquinone ansamycin analogs useful for the ... |
|
|
Invention
|
17-allylamino-17-demethoxygeldanamycin polymorphs and formulations.
Polymorphs and pharmaceutica... |
|
|
Invention
|
Methods of making epothilones. The invention provides novel compounds that may be used as interme... |
|
|
Invention
|
Process for the preparation of epothilones. Intermediates in the preparation of epothilones and e... |
|
|
Invention
|
Process for the preparation of epothilone precursor compounds. The invention relates to a novel p... |
|
|
Invention
|
Carbamate compounds. Carbamate compounds having a structure represented by formula (I) (where R1,... |
|
|
Invention
|
Carbamate compounds. 6 are as defined herein) are useful as anti-tumor agents.
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|
|
Invention
|
Macrolactams by engineered biosynthesis. geldanus NRRL 3602, wherein the gene cluster encoding en... |
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Invention
|
Macrolactams by engineered biosynthesis. Macrolactams are made by feeding aromatic amino acids as... |
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2007
|
Invention
|
Motilide polymorphs. The invention provides polymorphs of a motilide having a structure represent... |
|
|
Invention
|
Genetically modified cells and methods for converting (r)-methylmalonyl coa to (s)-methylmalonyl ... |
|
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Invention
|
Recombinant methods and materials for producing epothilone and epothilone derivatives. Recombinan... |
|
|
Invention
|
Production of polyketides.
Recombinant host cells of the suborder Cystobacterineae containing re... |
|
|
Invention
|
Biosynthetic gene cluster for leptomycins. Polypeptides and domains of leptomycin polyketide synt... |
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|
Invention
|
Synthetic genes.
The invention provides strategies, methods, vectors, reagents, and systems for ... |
|
|
Invention
|
Geldanamycin compounds and method of use. Geldanamycin compounds having a structure according to ... |
|
|
Invention
|
Macrocyclic kinase inhibitors. A compound having a structure according to formula (I) wherein R1,... |
|
|
Invention
|
Macrocyclic kinase inhibitors. A compound having a structure according to formula I
5 are as def... |
|
|
Invention
|
Recombinant polynucleotides encoding pro-geldanamycin producing polyketide synthases and accessor... |
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2006
|
Invention
|
Pharmaceutical formulations comprising 17-allylamino-17-demethoxygeldanamycin. A pharmaceutical f... |
|
|
Invention
|
7-quinolyl ketolide antibacterial agents. 15-fluoroketolides of the formula (I): having improved ... |
|
|
Invention
|
Pharmaceutical compositions comprising 17-allylamino-17-demethoxygeldanamycin.
A pharmaceutical ... |
|
|
Invention
|
7-quinolyl ketolide antibacterial agents. 15-fluoroketolides of the formula
having improved act... |
|
|
Invention
|
17-allylamino-17-demethoxygeldanamycin polymorphs and formulations. Polymorphs and pharmaceutical... |
|
|
Invention
|
Method for demethylating the 3'-dimethylamino group of erythromycin compounds.
A method for deme... |
|
|
Invention
|
Method of treating breast cancer. A method for treating a breast cancer in a subject by administe... |
|
|
Invention
|
Method of treating breast cancer using 17-aag or 17-ag or a prodrug of either in combination with... |
|
|
Invention
|
Esters of compounds in the leptomycin family. Esters of compounds in the leptomycin family, havin... |
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|
P/S
|
Pharmaceutical preparations, pharmaceuticals comprising polyketides for use in antibiotics, antic... |
|
|
Invention
|
Method of treating an aspergillus or cryptococcus infection by administering ambruticin vs-3, vs-... |
|
|
Invention
|
Method of treating a coccidioides infection by administering an ambruticin compound. A method of ... |
|
|
Invention
|
Method of treating multiple myeloma using 17-aag or 17-ag or a prodrug of either in combination w... |
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2005
|
Invention
|
Ambruticin vs compounds.
Antifungal compounds represented by formula I
where R1, R2, R3 a... |
|
|
Invention
|
Polyketide synthase enzymes and recombinant dna constructs therefor.
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|
|
Invention
|
Production of polyketides. Myxococcus host cells can be used to produce polyketides, including ep... |
|
|
Invention
|
Macrolide antinfective agents. including any pharmaceutically acceptable salts thereof and any st... |
|
|
Invention
|
Conjugates with reduced adverse systemic effects. A conjugate of an active agent and a targeting ... |
|
2004
|
Invention
|
Polynucleotides encoding the fkbb gene of the fk-520 polyketide synthase gene cluster. Host cells... |
|
2001
|
Invention
|
Design of polyketide synthase genes. Methods for the computational analysis of polyketides and th... |
