Abstract

A nonlinear optical crystal structure is provided. The nonlinear optical crystal structure includes a plurality of two-dimensional material films, wherein the plurality of two-dimensional material films are stacked in a direction perpendicular to a two-dimensional plane thereof, and two-dimensional material films adjacent to each other are bonded by van der Waals forces, each of the plurality of two-dimensional material films is a crystal with a center-inversion-asymmetric crystal structure, and has a predetermined lattice orientation parallel to the two-dimensional plane in a direction parallel to the two-dimensional plane, there is a non-zero twist angle between the two-dimensional material films adjacent to each other, and the twist angle is an included angle between predetermined lattice orientations of the two-dimensional material films adjacent to each other in the same two-dimensional plane, and a thickness of each of the plurality of two-dimensional material films is greater than 5 nm.

IPC Classes  ?

• G02F 1/355 - Non-linear optics characterised by the materials used
• G02F 1/35 - Non-linear optics
• G02F 1/37 - Non-linear optics for second-harmonic generation

Abstract

A spatial information trajectory visualization method supporting expression of uncertainty level, belonging to the field of visualization. The method comprises: on the basis of actual spatial information, extracting a spatial uncertainty level from spatial data to be expressed; according to the extracted spatial uncertainty level, performing abstract map node layout, organizing locations in the trajectory into a nested circular structure according to a spatial uncertainty level organization, placing locations having determined positions inside a circle, placing locations having uncertain positions on a circle boundary, and drawing a trajectory path using a quadratic Bézier curve. The present method targets spatial information trajectory data having an uncertainty level, and, by means of constraint conditions such as geographic space and linking relationships, obtains an optimized layout for abstract map nodes, thereby avoiding misunderstandings caused by uncertain places drawn on a geographic map, and retaining, as much as possible, known information and association relationships; trajectory characteristics can be objectively and effectively shown, and a reliable foundation is laid for the development of spatial information visualization.

IPC Classes  ?

• G06F 16/26 - Visual data miningBrowsing structured data

Abstract

An intelligent deformable microneedle includes a supporting seat; a counter electrode provided above the supporting seat; an elastic object with a compressed state and a natural state, where a working electrode is provided on an outer surface of the elastic object, and a specific enzyme that can react with an analyte to be detected is provided on the working electrode; a soluble needle-shaped body fixed on the supporting seat, where the soluble needle-shaped body completely wraps the counter electrode and the elastic object from the outside, and the soluble needle-shaped body has an inner cavity structure that enables the elastic object to be in the compressed state. The microneedle is internally provided with the elastic object, after penetrating into skin, the soluble needle-shaped body is dissolved, the elastic object inside is exposed, length becomes longer, and the working electrode of an electrochemical sensor is attached to the elastic object.

IPC Classes  ?

• A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
• B33Y 80/00 - Products made by additive manufacturing

Abstract

The present application provides methods for producing circular RNAs (circRNAs) from a DNA construct encoding a linear RNA precursor, wherein the linear RNA precursor comprises from the 5′-end to the 3′ end: a 3′ catalytic Group I intron fragment, a 3′ exon sequence, an effector RNA sequence, a 5′ exon sequence, and a 5′ catalytic Group I intron fragment, wherein the method comprises an in vitro single-pot reaction. In some embodiments, the single-pot reaction does not comprise supplementing the reagent composition with GTP, a divalent metal ion such as Mg2+, or DNase I prior to circularization of a linear RNA precursor.

IPC Classes  ?

• C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides

Abstract

Compositions useful for delaying reproductive aging in an individual comprise L-ergothioneine and ginsenoside Rb1. Methods of delaying reproductive aging, such as methods of treating age-related ovarian granulosa cell injury.

IPC Classes  ?

• A61K 31/4172 - Imidazole-alkanecarboxylic acids, e.g. histidine
• A61K 31/704 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
• A61P 15/08 - Drugs for genital or sexual disordersContraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis

Abstract

The present disclosure provides a semiconductor structure and a preparation method therefor, a semiconductor device, and an electronic device. The preparation method comprises: providing a substrate; sequentially forming a first material layer and a second material layer made of materials having different lattice constants on the substrate; etching the first material layer and the second material layer, to form a fin structure comprising a first part formed of the first material layer undergone etching and a second part formed of the second material layer undergone etching; forming an underlying transistor on the basis of the second part; and on the basis of the first part after flipping, forming a top layer transistor.

IPC Classes  ?

• H01L 21/8238 - Complementary field-effect transistors, e.g. CMOS
• H01L 27/092 - Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including integrated passive circuit elements with at least one potential-jump barrier or surface barrier the substrate being a semiconductor body including only semiconductor components of a single kind including field-effect components only the components being field-effect transistors with insulated gate complementary MIS field-effect transistors

Abstract

The present disclosure provides a semiconductor structure and a preparation method therefor, a semiconductor device, and an electronic device. The preparation method comprises: providing a substrate; forming an active structure on the substrate, the active structure having a first portion and a second portion; forming a shallow trench isolation layer on the substrate to cover the second portion; forming an etch stop layer on the shallow trench isolation layer; forming a bottom-layer transistor on the basis of the first portion; performing flip-chip processing and etching the substrate and the shallow trench isolation layer to expose the etch stop layer and the second portion; and forming a top-layer transistor on the basis of the second portion. A first gate structure of the bottom-layer transistor and a second gate structure of the top-layer transistor are located on two opposite sides of the etch stop layer.

IPC Classes  ?

• H01L 21/8238 - Complementary field-effect transistors, e.g. CMOS
• H01L 27/092 - Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including integrated passive circuit elements with at least one potential-jump barrier or surface barrier the substrate being a semiconductor body including only semiconductor components of a single kind including field-effect components only the components being field-effect transistors with insulated gate complementary MIS field-effect transistors

Abstract

Provided in the present disclosure are a semiconductor structure, a manufacturing method therefor, a semiconductor device and an electronic device. The method comprises: providing a substrate; forming an active structure on the substrate, the active structure comprising a first active structure and a second active structure; filling the active structure with an oxide to form shallow trench isolation; removing a first part of the shallow trench isolation so as to expose the first active structure; on the basis of the first active structure, forming a first transistor, a first gate structure of the first transistor wrapping the first active structure; depositing a first insulating layer on the top of the first transistor, and bonding the first insulating layer to a carrier wafer; flipping over the first transistor; removing the substrate and a second part of the shallow trench isolation so as to expose the second active structure; and, on the basis of the second active structure, forming a second transistor, a second gate structure of the second transistor wrapping the second active structure.

IPC Classes  ?

• H01L 21/8238 - Complementary field-effect transistors, e.g. CMOS
• H01L 27/092 - Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including integrated passive circuit elements with at least one potential-jump barrier or surface barrier the substrate being a semiconductor body including only semiconductor components of a single kind including field-effect components only the components being field-effect transistors with insulated gate complementary MIS field-effect transistors

Abstract

The present invention provides a preparation method for a semiconductor structure, a semiconductor structure and device, and a device. The method comprises: forming active structures on a substrate, the active structures comprising first active structures and second active structures, and the first active structures being distant from the substrate with respect to the second active structures; forming on the substrate isolation structures surrounding the second active structures, so as to expose the first active structures; on the basis of the first active structures, forming a first transistor, the first transistor at least comprising a first gate structure; performing a flip operation on the first transistor to expose the second active structures; on the basis of the second active structures, forming a second transistor, the second transistor at least comprising a second gate structure; and forming an interconnection structure in a first area, the interconnection structure being used for connecting the first gate structure and the second gate structure, and the first area being located between the active structures and the boundary of one side of a gate area.

IPC Classes  ?

• H01L 21/8238 - Complementary field-effect transistors, e.g. CMOS
• H01L 27/092 - Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including integrated passive circuit elements with at least one potential-jump barrier or surface barrier the substrate being a semiconductor body including only semiconductor components of a single kind including field-effect components only the components being field-effect transistors with insulated gate complementary MIS field-effect transistors

Abstract

Provided in the present disclosure are a semiconductor structure and a preparation method therefor, and a semiconductor device and an electronic device. The preparation method comprises: forming an active structure on a semiconductor substrate, wherein the active structure comprises a first active structure and a second active structure; forming a first transistor on the basis of the first active structure, wherein the first transistor comprises a first source-drain structure, a first source-drain metal and a first interlayer dielectric layer; inverting the first transistor, and removing the semiconductor substrate; and forming a second transistor on the basis of the second active structure, wherein the second transistor comprises a second source-drain structure, a second source-drain metal and a second interlayer dielectric layer, the first source-drain metal and the second source-drain metal being connected by means of an interconnection through-hole structure, and the interconnection through-hole structure penetrating the first interlayer dielectric layer and the second interlayer dielectric layer.

IPC Classes  ?

• H01L 21/8234 - MIS technology
• H01L 21/8238 - Complementary field-effect transistors, e.g. CMOS
• H01L 27/088 - Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including integrated passive circuit elements with at least one potential-jump barrier or surface barrier the substrate being a semiconductor body including only semiconductor components of a single kind including field-effect components only the components being field-effect transistors with insulated gate

Abstract

The present disclosure provides the utilization of an RPN11 marker in detecting myeloma and assessing disease risk, prognostic analysis, and therapeutic drug development. This includes a detection reagent and a kit for detecting smoldering multiple myeloma (SMM) and multiple myeloma (MM) and assessing disease risk. Additionally, it involves molecular typing of MM patients' cassette, prognostic analysis of the MM patients, and predicting the response of the MM patients to a bortezomib treatment. It entails the use of an RPN11 inhibitor in preparation of a pharmaceutical composition for treating MM characterized by drug-resistant t(4;14) translocation and a high RPN11 expression level. Notably, the combined use of the RPN11 with histone methyltransferase (HMT) enhances detection sensitivity and accuracy, preventing a mismatch between the patients' genotype and the prediction of disease development, and can effectively predict the overall survival and prognosis of MM patients with t(4;14) translocation.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• A61K 31/4709 - Non-condensed quinolines containing further heterocyclic rings
• A61P 35/00 - Antineoplastic agents
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

A photosensitizer chimera targeting PD-L1 protein, and a preparation method therefor and a use thereof. The photosensitizer chimera is of an X-R-G structure, wherein X is a photosensitizer unit, R is a linker, G is a polypeptide unit targeting PD-L1 protein, the photosensitizer is a porphyrin photosensitizer, and the excitation light wavelength of the photosensitizer is longer than 550 nm; the molar absorption coefficient at the maximum absorption wavelength longer than the wavelength of 550 nm is greater than 1000 M -1cm-1; the quantum yield of a triplet state exceeds 0.01; the linker is selected from the following structural formulas, wherein the amino side of the linker is connected to the photosensitizer unit, the carboxyl side of the linker is connected to the polypeptide unit, and n is an integer of 0-50; the binding constant of the polypeptide and h-PD-L1 is less than 20 µm. Combination therapy of immune checkpoint blockade and cytotoxicity induced by the photosensitive chimera based on photodegradation of PD-L1 protein in PD-1/PD-L1 can cause stronger immune response than monotherapy, and thus the photosensitive chimera has great potential in enhancing antitumor therapy.

IPC Classes  ?

• C07K 19/00 - Hybrid peptides
• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention discloses a method for enhancing the activity of a photosensitizer by a magnetic field, in which the photosensitizer is placed in the magnetic field under light conditions, thus improving the cytotoxicity of the photosensitizer to tumor cells and increasing the activity of the photosensitizer, thereby further enhancing the apoptosis of cancer cells or an inhibitory effect on tumor tissue by using photodynamic treatment methods, which helps to improve an effect of photodynamic therapy.

IPC Classes  ?

• A61N 5/06 - Radiation therapy using light

Abstract

The present disclosure provides a carborane-phospholipid conjugate, in which carboranyl is introduced at the end of the arm of a phospholipid. The present disclosure also provides a liposome composition including the carborane-phospholipid conjugate, and a use of the composition in delivering at least one therapeutic agent and/or at least one diagnostic agent.

IPC Classes  ?

• C07F 9/09 - Esters of phosphoric acids
• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids

Abstract

Disclosed is a method for implementing a content addressable memory based on an ambipolar FET, wherein a linear non-separable comparison operation required for a CAM cell is realized based on a single ambipolar FET with a threshold voltage through interposing a memory layer between a gate dielectric layer and a control gate of the ambipolar FET in source/drain symmetry to modulate the threshold voltage for information storage and through utilizing its non-monotonic transfer characteristics for input search.

IPC Classes  ?

• G11C 15/04 - Digital stores in which information comprising one or more characteristic parts is written into the store and in which information is read-out by searching for one or more of these characteristic parts, i.e. associative or content-addressed stores using semiconductor elements

Abstract

The present application provides a method and kit for detecting N6-methyladenine in a nucleic acid molecule.

IPC Classes  ?

• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

Abstract

The present disclosure provides an immunoassay device, and a preparation method and use thereof, and belongs to the technical field of biological detection. In the present disclosure, the immunoassay device includes a test strip and a thin film pump, where a driving component in the thin film pump is connected to a printed circuit board (PCB) or a chip outside the thin film pump through a wire, to control starting or turning off of the thin film pump; and a liquid outlet of the thin film pump is closely attached to a top of a conjugate pad of the test strip, or a top of a sample pad of the test strip, or a top of a middle part between the conjugate pad and the sample pad.

IPC Classes  ?

• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 21/84 - Systems specially adapted for particular applications

Abstract

The present disclosure provides a TSV interposer and a manufacturing method therefor, and a three-dimensional chip. The TSV interposer comprises: a substrate provided therein with a cavity and a first structure layer covering part of the inner wall of the cavity, wherein the material type of the first structure layer is different from that of the substrate; a through via structure running through the substrate and located on one side of the cavity; and liquid metal located in the cavity, wherein the liquid metal and the first structure layer comprise the same material element. According to the present disclosure, the problem in the prior art of poor heat dissipation capability of TSV interposers is solved.

IPC Classes  ?

• H01L 23/498 - Leads on insulating substrates

Abstract

The present invention relates to a pharmacokinetics modified FAP-α specific radiopharmaceutical and a use thereof, and specifically provides a novel pharmacokinetic linker modified OncoFAP molecule. The molecule can be coupled to bifunctional chelators (BFCs), including HYNIC, MAG2, MAG3, DTPA, DOTA, NOTA, (±)-H3RESCA, TETA, etc., for labeling nuclides such as 99mTc, 68Ga, 64Cu, 18F, 111In, 90Y, and 177Lu, and then, by using nuclear medicine imaging technology, imaging diagnosis and nuclide therapy are carried out on FAP-positive tumors or fibrotic diseases.

IPC Classes  ?

• C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• A61K 31/4709 - Non-condensed quinolines containing further heterocyclic rings
• A61P 35/00 - Antineoplastic agents
• A61K 51/04 - Organic compounds

Abstract

The present invention relates to the technical field of visualization and human-computer interaction, and in particular to a visual analysis system and method for astronomical spectrum type inspection. The system comprises: a data preprocessing module used for preprocessing reference spectra and spectra to be inspected, to complete spectrum normalization, spectrum feature detection and spectrum characterization; a selection module used for helping a user to select a spectrum to be inspected and determine a possible redshift and important spectral lines under the redshift; an inspection module used for helping the user to determine the redshift and type of the spectrum to be inspected, the inspection module comprising an adjustment sub-module, a recommendation sub-module and a verification sub-module, which are respectively used for adjusting the redshift of the spectrum to be inspected, recommending a proper spectral line to the user and evaluating an inspection result; and a promotion module used for helping the user to obtain other spectra similar to the inspected spectrum by means of searching. The system and method provided by the present invention can significantly improve the classification efficiency while ensuring the spectrum classification accuracy of experts.

IPC Classes  ?

• G01N 21/25 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
• G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
• G06V 10/58 - Extraction of image or video features relating to hyperspectral data

Abstract

The present disclosure provides compounds that can inhibit the type III secretion system (TTSS) to decrease the pathogenesis of gram-negative bacteria. These compounds may have wide applications for treating bacteria diseases caused by gram-negative bacteria in a host species, including but not limited to, plants and animals. The present invention further relates to compositions that inhibit pathogenesis of gram-negative bacteria without killing the bacteria. Methods relating to preventing and/or treating infection of a host species by bacterial pathogens are also provided herein.

IPC Classes  ?

• C07C 233/09 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an acyclic unsaturated carbon skeleton
• A01N 33/04 - Nitrogen directly attached to aliphatic or cycloaliphatic carbon atoms
• A01N 37/18 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N, e.g. carboxylic acid amides or imidesThio-analogues thereof
• A01N 37/20 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N, e.g. carboxylic acid amides or imidesThio-analogues thereof containing the group , wherein Cn means a carbon skeleton not containing a ringThio-analogues thereof
• A01N 37/28 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N, e.g. carboxylic acid amides or imidesThio-analogues thereof containing the group Thio-analogues thereof
• A01N 43/08 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom five-membered rings with oxygen as the ring hetero atom
• A01P 1/00 - DisinfectantsAntimicrobial compounds or mixtures thereof
• A61K 31/131 - Amines, e.g. amantadine acyclic
• A61K 31/16 - Amides, e.g. hydroxamic acids
• A61K 31/164 - Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
• A61K 31/165 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
• A61K 31/17 - Amides, e.g. hydroxamic acids having the group N—C(O)—N or N—C(S)—N, e.g. urea, thiourea, carmustine
• A61K 31/365 - Lactones
• C07C 211/21 - Monoamines
• C07C 231/02 - Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
• C07C 233/05 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
• C07C 233/11 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
• C07C 233/18 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
• C07C 233/20 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
• C07C 239/14 - Hydroxylamino compounds or their ethers or esters having nitrogen atoms of hydroxylamino groups further bound to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
• C07C 273/18 - Preparation of urea or its derivatives, i.e. compounds containing any of the groups the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
• C07C 275/20 - Derivatives of urea, i.e. compounds containing any of the groups the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
• C07D 307/33 - Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form

Abstract

Disclosed is a lateral flow immunoassay device for albumin detection, including one or more strips that are formed by sequentially connecting the following components: a) a sample pad for receiving a sample to be tested; b) a conjugate pad for temporarily storing a gold nanoparticle labeled antibody; c) a test region for immobilizing an antigen, a nitrocellulose membrane being arranged above the test region; and d) an absorbent pad for increasing capillarity; two ends of the nitrocellulose membrane overlap with the conjugate pad and the absorbent pad at an overlapping length of 1 mm to 5 mm, respectively; and further including: e) a backing card for supporting the above components, the backing card being a transparent glass, an upper surface of the transparent glass being provided with the test region for immobilizing the antigen to capture the gold nanoparticle labeled antibody, and the transparent glass being pretreated by silanization.

IPC Classes  ?

• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

A nanoparticle drug based on a small interfering RNA (siRNA) targeting JFK and use thereof are provided. Nucleotide sequences of the sense strand and the antisense strand of the siRNA targeting JFK are set forth in SEQ ID NO: 1 and SEQ ID NO: 2, respectively. Liposomes can be used to encapsulate the complex of the siRNA and a protamine to produce a nanoparticle drug targeting JFK, which may be used to treat a disease related to abnormally-high expression of JFK. In this disclosure, breast cancer 4T1 cell-based tumor-bearing mice serve as the model for evaluating the anti-tumor activity of combined therapy involving the nanoparticle drug targeting JFK and radiotherapy. The results reveal that this combined therapy exhibits superior anti-tumor activity compared to the control group.

IPC Classes  ?

• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 9/51 - Nanocapsules
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61K 38/02 - Peptides of undefined number of amino acidsDerivatives thereof
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

Provided in the present application are a kind of aza[3.2.1] bridged ring substituted fluorescent dye, and a preparation method therefor and the use thereof. In this kind of fluorescent dye, the aza [3.2.1] bridged ring is used as the substituent of the fluorescent dye, which significantly improves the brightness and light stability of the fluorescent dye, completely avoids a blue shift of light of the dye after long-term illumination, and can also effectively improve the water solubility of the fluorescent dye and maintains good cell membrane permeability thereof. Also provided in the present application are embodiments of functionalized derivatives of this kind of dye for single-molecule imaging, confocal imaging and super-resolution imaging in biological samples.

IPC Classes  ?

• C09B 19/00 - Oxazine dyes
• C09B 57/00 - Other synthetic dyes of known constitution
• C07D 451/00 - Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.02,4] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamineCyclic acetals thereof
• A61K 31/46 - 8-Azabicyclo [3.2.1] octaneDerivatives thereof, e.g. atropine, cocaine
• G01N 33/533 - Production of labelled immunochemicals with fluorescent label
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances

Abstract

A radiation-activatable compound, a drug conjugate thereof and the use thereof, and the use of the compound as a drug conjugate linking group.

IPC Classes  ?

• C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 217/12 - Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
• C07D 213/02 - Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61K 49/00 - Preparations for testing in vivo
• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• A61P 35/00 - Antineoplastic agents

Abstract

The present disclosure provides a complementary storage circuit and a memory. The complementary storage circuit comprises storage units distributed in a matrix array, each storage unit comprises at least one group of P-channel field-effect transistors and N-channel field-effect transistors which are alternately connected, sources of the P-channel field-effect transistors are connected to drains of the N-channel field-effect transistors, and drains of the P-channel field-effect transistors are connected to sources of the N-channel field-effect transistors. According to the present disclosure, the density of a storage array can be improved, and the requirements for the driving capability of field-effect transistors are reduced.

IPC Classes  ?

• G11C 16/04 - Erasable programmable read-only memories electrically programmable using variable threshold transistors, e.g. FAMOS

Abstract

Disclosed is a method for monolithic integration preparation of a full-color nitride semiconductor micro light-emitting diode (micro-LED) array. The method includes preparing a composite conductive substrate; overlaying an insulating template onto the composite conductive substrate to prepare a template substrate; overlaying monocrystalline graphene onto the template substrate in a completely aligned manner to obtain a customized template graphene substrate including graphene array units, wherein one blue-region graphene array element, one green-region graphene array element, and two red-region graphene array elements in each graphene array unit have surface properties different from each other; then performing an in-situ process to epitaxially grow a vertical-structure all-nitride material, to obtain a full-color micro-LED array epitaxial wafer by one-step in-situ process; finally, performing packaging and preparing a transparent electrode, to obtain a vertical-structure full-color nitride micro-LED array with top light emission.

IPC Classes  ?

• H01L 33/00 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof
• H01L 25/075 - Assemblies consisting of a plurality of individual semiconductor or other solid-state devices all the devices being of a type provided for in a single subclass of subclasses , , , , or , e.g. assemblies of rectifier diodes the devices not having separate containers the devices being of a type provided for in group

Abstract

The present invention provides a method for co-expressing two or more proteins. Specifically, the present invention provides a method for co-expressing two or more proteins in a cell or a cell-free system by using a linker comprising one or more Mitochondrial Processing Peptidase (MPP) cleavable sequences. This invention also provides an MPP cleavable sequence, a fusion protein comprising the MPP cleavable sequence, a nucleic acid or a vector encoding the MPP cleavable sequence or the fusion protein, and a cell expressing the MPP cleavable sequence or the fusion protein.

IPC Classes  ?

• C07K 19/00 - Hybrid peptides
• C12P 21/00 - Preparation of peptides or proteins
• C12N 15/62 - DNA sequences coding for fusion proteins
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression
• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells

Abstract

The present disclosure provides a storage array, comprising storage units distributed in a matrix array, wherein each storage unit comprises two memories, and one P-channel field effect transistor and two N-channel field effect transistors which are alternately connected; the source electrode of the P-channel field effect transistor is connected to the drain electrode of each N-channel field effect transistor; the drain electrode of the P-channel field effect transistor is connected to the source electrode of the N-channel field effect transistor; the two memories are respectively connected to the source electrode of the P-channel field effect transistor and the source electrode of the N-channel field effect transistor. Use of the present invention can improve the density of the storage array and reduce the requirements for the driving capability of field effect transistors.

IPC Classes  ?

• G11C 11/4074 - Power supply or voltage generation circuits, e.g. bias voltage generators, substrate voltage generators, back-up power, power control circuits

Abstract

Provided in the present disclosure is a CMOS storage array, comprising storage units distributed in a matrix array, each storage unit comprising a memory, and a P-channel field effect transistor and an N-channel field effect transistor, which are connected in series, wherein a source electrode of the P-channel field effect transistor is connected to a drain electrode of the N-channel field effect transistor, a drain electrode of the P-channel field effect transistor is connected to a source electrode of the N-channel field effect transistor, and one end of the memory is connected to the drain electrode of the P-channel field effect transistor. By using the disclosure, the density of the storage array can be increased, and the requirement for a driving capability of a field effect transistor can be reduced.

IPC Classes  ?

• H10B 63/00 - Resistance change memory devices, e.g. resistive RAM [ReRAM] devices

Abstract

Provided are methods and agents for promoting erythroid differentiation. Also provided are methods of increasing RNA polymerase II pausing mediated by a MED26 polypeptide. Also provided are methods of delivering a reagent to a cell.

IPC Classes  ?

• C12N 5/078 - Cells from blood or from the immune system
• C12N 5/0789 - Stem cellsMultipotent progenitor cells
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans

Abstract

Embodiments of the present disclosure provide a repair patch generation method, a storage medium, and an electronic device. The method comprises: constructing a program code comprising a defect code into a first abstract syntax tree, and converting the first abstract syntax tree into a type flow graph by means of a type flow graph constructor, wherein the first abstract syntax tree carries type information; traversing the type flow graph to obtain a node sequence, an attribute sequence and a relation matrix, and inputting the node sequence, the attribute sequence and the relation matrix into a type flow graph encoder to obtain a feature vector; and inputting the feature vector and a grammar rule word list into a syntax-directed generator to obtain a second abstract syntax tree, and performing code instantiation on the second abstract syntax tree to generate a repair patch, wherein the second abstract syntax tree carries the type information.

IPC Classes  ?

• G06F 8/41 - Compilation

Abstract

Provided are methods and systems for inhibiting nonsense-mediated mRNA decay in a gene-specific manner, for example in the treatment of diseases or disorders related to premature termination codons (PTCs).

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61K 31/712 - Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose

Abstract

The present invention belongs to the field of nuclear medicine and relates to a Granzyme B-targeting complex, a radiopharmaceutical, a preparation method therefor and a use thereof. A structure of the Granzyme B-targeting complex is shown in formula (I), where R is any one of a bifunctional chelating group or a derivative thereof for radionuclide labeling. The Granzyme B-targeting complex provided by the present invention can be prepared into the Granzyme B-targeting radiopharmaceutical through radionuclide labeling. The Granzyme B-targeting radiopharmaceutical provided is simple to prepare and has better pharmacokinetic characteristics and in vivo metabolic stability than other Granzyme B-targeting drugs. The expression level of Granzyme B in vivo can be monitored noninvasively by nuclear medicine imaging. The present invention belongs to the field of nuclear medicine and relates to a Granzyme B-targeting complex, a radiopharmaceutical, a preparation method therefor and a use thereof. A structure of the Granzyme B-targeting complex is shown in formula (I), where R is any one of a bifunctional chelating group or a derivative thereof for radionuclide labeling. The Granzyme B-targeting complex provided by the present invention can be prepared into the Granzyme B-targeting radiopharmaceutical through radionuclide labeling. The Granzyme B-targeting radiopharmaceutical provided is simple to prepare and has better pharmacokinetic characteristics and in vivo metabolic stability than other Granzyme B-targeting drugs. The expression level of Granzyme B in vivo can be monitored noninvasively by nuclear medicine imaging.

IPC Classes  ?

• A61K 51/04 - Organic compounds
• A61P 35/00 - Antineoplastic agents

Abstract

A bacterial capsular oligosaccharide derivative, a preparation method therefor, a pharmaceutical composition and a use thereof. The derivative is as shown in formula (I), and the substituent is described in detail in the description. The derivative has anti-inflammatory activity and can be used for treating sepsis. A bacterial capsular oligosaccharide derivative, a preparation method therefor, a pharmaceutical composition and a use thereof. The derivative is as shown in formula (I), and the substituent is described in detail in the description. The derivative has anti-inflammatory activity and can be used for treating sepsis.

IPC Classes  ?

• A61K 31/715 - Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkagesDerivatives thereof, e.g. ethers, esters
• A61K 31/7028 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• C07H 1/00 - Processes for the preparation of sugar derivatives
• C07H 15/04 - Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of a saccharide radical
• C07H 15/18 - Acyclic radicals, substituted by carbocyclic rings

Abstract

The present application relates to the technical field of two-dimensional materials, and relates to a transition metal chalcogenide wafer and a preparation method and apparatus therefor. The preparation method comprises: S1, assembling growth modules; and S2, vertically stacking the assembled growth modules to obtain a combined growth module; and placing the combined growth module in a container, heating to a preset temperature in an inert gas protection atmosphere, and carrying out chemical vapor deposition to obtain a wafer. The method uses a "plane-to-plane" local element supply technology, uses a highly reactive precursor, and effectively solves the uneven supply problem of "point-to-plane" diffusion growth sources in a traditional mode; using the precursor element supply method of the present application can greatly expand the size of prepared wafers, and expand the size of a single transition metal chalcogenide wafer to 12 inches or above, reaching a standard compatible with a contemporary semiconductor process; additionally, the batch production of a plurality of wafers can be realized by successively stacking growth modules.

IPC Classes  ?

• C30B 25/02 - Epitaxial-layer growth
• C30B 25/12 - Substrate holders or susceptors
• C30B 29/48 - AIIBVI compounds
• C30B 29/46 - Sulfur-, selenium- or tellurium-containing compounds
• H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof

Abstract

Provided are a 7-hydroxy-butylphthalide nano-emulsion formulation, a preparation method therefor and a use thereof. Specifically, a 7-hydroxy-butylphthalide nano-emulsion formulation containing a phospholipid PEG derivative is developed, and a molecular action mechanism of 7-hydroxy-butylphthalide, a phospholipid and a phospholipid PEG derivative in the formulation is disclosed by means of multi-scale calculation simulation; the specification of the formulation is determined by means of prescription and process optimization; and the effectiveness of the formulation in treating cerebral apoplexy is verified by means of animal in-vivo pharmacodynamics evaluation, providing a reliable dosage form for meeting clinical medication. The present invention solves the problems of poor solubility of 7-hydroxy-butylphthalide and difficulty in drug preparation. Upon quality inspection, the encapsulation efficiency, the particle size, the Zeta potential and the like of the 7-hydroxy-butylphthalide nano-emulsion formulation meet the quality requirements of nano-drug formulations, the 7-hydroxy-butylphthalide nano-emulsion formulation is applied to the treatment of cerebral apoplexy of rats, and the treatment effect shows that the 7-hydroxy-butylphthalide nano-emulsion formulation has the potential of clinically treating tumors and great application value.

IPC Classes  ?

• A61K 9/107 - Emulsions
• A61K 31/365 - Lactones
• A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

The present application relates to the technical field of magnetoencephalography detection. Provided are an atomic magnetometer magnetoencephalography system based on wireless transmission, and a magnetoencephalography detection method. The system comprises a worn structural member (100), an atomic magnetometer (200), a collection upper computer (300) and a manipulation module (400), wherein the atomic magnetometer (200) can form a magnetic field detection array; the collection upper computer (300) can be used for storing a magnetoencephalography signal collected by the atomic magnetometer (200); and the manipulation module (400) is electrically connected to the atomic magnetometer (200) by means of a flexible printed circuit (700), and the manipulation module (400) is connected to the collection upper computer (300) by means of a wireless communication. In the present application, a manipulation module can be connected to a collection upper computer without the need for a wired circuit, such that a wearer is not bound by the circuit during a test period, thereby solving the problem of the activity of a testee being limited. Moreover, there is no need to use a wired circuit between the manipulation module and the collection upper computer, and therefor there is no need to take the specification and cost of the wired circuit into consideration.

IPC Classes  ?

• A61B 5/245 - Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents specially adapted for magnetoencephalographic [MEG] signals

Abstract

A method for implementing a universal content addressable memory on the basis of N-type and P-type ferroelectric field effect transistors, which relates to the technical fields of novel storage and computation. According to the method, the complementary characteristics of an N-type FeFET and a P-type FeFET are utilized, so that it is possible to simultaneously achieve the functions of a TCAM, MACM and ACAM without extra hardware overhead. Moreover, a simpler search operation is provided, so that the storage density and search energy efficiency of a CAM are improved. When quantized into an MCAM that stores multi-level entry states, the CAM also has the ability to compress entry states, allowing the storage density of the CAM to be further improved, which is of great significance for CAM-based table lookup search operations.

IPC Classes  ?

• G11C 11/22 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using electric elements using ferroelectric elements

Abstract

xyz1-x-y-z22, wherein Li layers and transition metal layers are alternately arranged, 0.1

IPC Classes  ?

• H01M 4/505 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of manganese of mixed oxides or hydroxides containing manganese for inserting or intercalating light metals, e.g. LiMn2O4 or LiMn2OxFy

Abstract

The disclosure discloses a method for parsing method and device, and an electronic device. The method includes: receiving a target instruction and a parameter processor set, wherein the target instruction includes a target instruction parameter vector, a composition element of the target instruction parameter vector is a target instruction parameter, the parameter processor set includes at least one parameter processor, and the parameter processor consists of a preset to-be-matched command parameter vector and a first preset anonymous function; determining, from the parameter processors, a target parameter processor matching the target instruction parameter in the target instruction parameter vector, and processing the target instruction parameter by using the target parameter processor, to obtain a processing result; and determining, according to the processing result, a processing command corresponding to the target instruction, and executing the processing command.

IPC Classes  ?

• G06F 9/30 - Arrangements for executing machine instructions, e.g. instruction decode

Abstract

The embodiments of the present application provide a compilation optimization option grouping method, a computer device, and a storage medium, and belong to the field of computers. The method comprises: acquiring function call relationship information of a compiler (S101); according to the function call relationship information, grouping all of the compilation optimization options in the compiler, and obtaining a plurality of target compilation optimization option groups (S102); and using the plurality of target compilation optimization option groups as a target search space of the compiler (S103).

IPC Classes  ?

• G06F 11/36 - Prevention of errors by analysis, debugging or testing of software

Abstract

An optimization and enhancement method for medical health physical examination big data includes following steps: all closed edges and all feature corner points in an anteroposterior spinal X-ray image are obtained, an internal difference coefficient of each closed edge relative to each other closed edge is obtained based on a positional distribution difference coefficient of each feature corner point within each closed edge relative to each feature corner point within each other closed edge, and the vertebral body edge probability of each closed edge is obtained by combing a rectangularity degree of each closed edge; the vertebral body edge confidence probability is obtained based on the rectangularity degree and the number of the feature corner points within each closed edge to select a reference vertebral body edge; all spinal vertebral bodies are obtained by a feature matching algorithm and grayscale enhancement is performed on all spinal vertebral bodies.

IPC Classes  ?

• G06T 7/00 - Image analysis
• G06T 5/40 - Image enhancement or restoration using histogram techniques

Abstract

The present disclosure provides a three-dimensional semiconductor memory array architecture and a preparation method therefor. The three-dimensional semiconductor memory array architecture comprises storage units consisting of novel memories distributed in multiple layers in the vertical direction, and vertical structures arranged between adjacent storage units, wherein vertical transistors are arranged in the vertical structures. Each novel memory has one end connected to a channel of the corresponding vertical transistor, and the other end connected to a bit line (BL) in the horizontal direction; the channel of the vertical transistor is connected to a source line (SL) in the horizontal direction; and a gate of the vertical transistor is wrapped in the center of the vertical structure by a gate dielectric material layer and a channel material layer. The present disclosure can meet the requirements of material diversity, array reliability, and process compatibility for novel memories, and is suitable for the integration of large-scale novel memory arrays.

IPC Classes  ?

• H10B 63/00 - Resistance change memory devices, e.g. resistive RAM [ReRAM] devices
• H10B 63/10 - Phase change RAM [PCRAM, PRAM] devices
• H10B 61/00 - Magnetic memory devices, e.g. magnetoresistive RAM [MRAM] devices
• H10B 51/20 - Ferroelectric RAM [FeRAM] devices comprising ferroelectric memory transistors characterised by the three-dimensional arrangements, e.g. with cells on different height levels
• H10B 53/20 - Ferroelectric RAM [FeRAM] devices comprising ferroelectric memory capacitors characterised by the three-dimensional arrangements, e.g. with cells on different height levels

Abstract

Provided are methods of forming circularized RNA (circRNA) using intact Group I introns provided in cis or fragments of Group I introns provided in trans. Also provided are methods of forming circRNA using intact Group II introns provided in cis or fragments of Group II introns provided in trans.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy

Abstract

The present invention relates to the field of biomedicine, in particular regenerative medicine. In particular, the present invention relates to a method for producing cardiomyocytes from differentiated cells, such as fibroblasts, by means of reprogramming using a Tyk2 inhibitor and/or a TGFβ inhibitor, and optionally a cardiomyocyte-inducing transcription factor.

IPC Classes  ?

• C12N 5/077 - Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
• C12N 15/86 - Viral vectors

Abstract

A ternary content addressable memory, which comprises: an oxide semiconductor array, a peripheral write word line drive circuit connected to the oxide semiconductor array, a TCAM input, a precharging and comparison circuit, and a logic circuit; the write word line drive circuit is used for driving a write word line of the oxide semiconductor array; the TCAM input is used for inputting data to be queried; the precharging and comparison circuit is used for precharging a read word line corresponding to the data to be queried, comparing the voltage of the read word line against a preset reference voltage, and outputting a comparison result; and the logic circuit is used for determining, according to the comparison result, a storage address corresponding to the data to be queried. The use of the ternary content addressable memory increases the energy efficiency and degree of parallelism of searches carried out by the ternary content addressable memory.

IPC Classes  ?

• G11C 15/04 - Digital stores in which information comprising one or more characteristic parts is written into the store and in which information is read-out by searching for one or more of these characteristic parts, i.e. associative or content-addressed stores using semiconductor elements

Abstract

A compute-in-memory circuit based on charge redistribution includes a memory array, multiple-functional output units (MFUs), multiplexers (MUXs), and a word line (WL) driver. The memory array includes memory cell rows and memory cell columns. Every two adjacent memory cells form a memory cell pair in sequence, and every two adjacent memory cell columns form a memory cell column pair in sequence. A grounded register capacitor is connected to a source line (SL) of each memory cell row. Input ends of each MFU are connected to a first bit line (BL) and a second BL of each memory cell column pair, respectively. Each MUX includes voltage-input ends and an output end, and the output end of each MUX is connected to the SL of each memory cell row in a one-to-one correspondence. An output end of the WL driver is connected to a WL of each memory cell row.

IPC Classes  ?

• G11C 7/10 - Input/output [I/O] data interface arrangements, e.g. I/O data control circuits, I/O data buffers
• G11C 7/12 - Bit line control circuits, e.g. drivers, boosters, pull-up circuits, pull-down circuits, precharging circuits, equalising circuits, for bit lines

Abstract

Provided are methods for inducing exon skipping in a pre-mRNA in a host cell comprising introducing a deaminase-recruiting RNA (dRNA) or a construct comprising a nucleic acid encoding the dRNA into the host cell, wherein the dRNA is a circular RNA (circRNA) or forms a circRNA within the host cell.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy

Abstract

The present disclosure relates to the technical field of electrochemistry, and in particular, to a threadlike sensor, a wearable device and a method for fabricating the threadlike sensor. The threadlike sensor includes a thread core, an inner insulating layer, an outside electrode layer and an outer insulating layer. The inner insulating layer covers the thread core with two ends of the thread core being exposed by the inner insulating layer. The outside electrode layer is disposed outside the inner insulating layer. The outer insulating layer covers the outside electrode layer with two ends of the outside electrode layer being exposed by the outer insulating layer. One end of the threadlike sensor is a detection end configured for placement in a human body. The other end of the threadlike sensor is an interface end configured for external connection. The thread core and the outside electrode layer are configured for sensitivity testing.

IPC Classes  ?

• G01N 27/28 - Electrolytic cell components
• B29C 63/08 - Lining or sheathing, i.e. applying preformed layers or sheathings of plasticsApparatus therefor using sheet or web-like material by folding, winding, bending or the like by winding helically
• G01N 27/327 - Biochemical electrodes
• G01N 27/403 - Cells and electrode assemblies

Abstract

A method for continuous epitaxy of a carbon film, including the following steps: Si, providing a foil, wherein the foil is selected from a nickel foil or a copper-nickel alloy foil and has a first surface and a second surface; and S2, using the foil as a substrate and placing it on a solid carbon source, wherein the first surface of the foil is positioned close to the solid carbon source, while the second surface of the foil is positioned away from the solid carbon source, and then heating the foil and the solid carbon source, so that a carbon film is formed by continuous epitaxy on the second surface of the foil.

IPC Classes  ?

• C01B 32/205 - Preparation
• C30B 1/02 - Single-crystal growth directly from the solid state by thermal treatment, e.g. strain annealing

Abstract

The present application discloses an external-cavity diode laser based on a Voigt anomalous dispersion atomic optical filter. The laser includes: a laser diode coated with an anti-reflective coating, where the laser diode is provided with a temperature control module thereon; a collimation module, configured to perform collimation and expanding for the laser diode; the Voigt anomalous dispersion atomic optical filter, configured to filter laser light emitted from the laser diode, where a spectrum of laser light output from the laser depends on a transmission spectrum of the atomic optical filter; a reflective cavity mirror, configured to reflect the laser light filtered by the atomic optical filter back into a resonant cavity to form oscillation and produce stable laser light; a piezoelectric ceramic, assembled with the reflective cavity mirror and configured to fine-tune a cavity length of the laser to achieve tuning of the laser light.

IPC Classes  ?

• H01S 5/14 - External cavity lasers
• H01S 3/08 - Construction or shape of optical resonators or components thereof
• H01S 3/105 - Controlling the intensity, frequency, phase, polarisation or direction of the emitted radiation, e.g. switching, gating, modulating or demodulating by controlling the mutual position or the reflecting properties of the reflectors of the cavity
• H01S 5/00 - Semiconductor lasers
• H01S 5/02326 - Arrangements for relative positioning of laser diodes and optical components, e.g. grooves in the mount to fix optical fibres or lenses
• H01S 5/024 - Arrangements for thermal management
• H01S 5/028 - Coatings

Abstract

Disclosed are a diabetes sensor, a method for manufacturing the diabetes sensor, and a closed-loop control system. The diabetes sensor includes a substrate, a microneedle array arranged on one side of the substrate, and a plurality of electrodes covering the microneedle array and the substrate, wherein the microneedle array includes a plurality of microneedles; and the plurality of electrodes includes an electrochemical sensor and a reverse iontophoresis device; the electrochemical sensor being configured to detect glucose molecules in interstitial fluid and generate an electrical signal; and the reverse iontophoresis device being configured to generate a reverse iontophoresis effect to attract glucose molecules in a deep skin layer to an upper part of dermis where needle tips of the microneedles are located.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
• A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
• A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin

Abstract

The present invention relates to the technical filed of biomedicine, and relates to a Tmem52 protein fragment, an encoding gene, a recombinant vector, a recombinant microorganism, and a use thereof. The Tmem52 protein fragment can reduce weight, increase basal metabolic rate, prevent and treat obesity, increase insulin sensitivity, improve blood glucose regulation ability, prevent and treat diabetes, reduce serum triglyceride level, and prevent and treat hyperlipidemia, and can also be used for treating obesity and related diseases, such as diabetes and hyperlipidemia.

IPC Classes  ?

• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• A61P 9/00 - Drugs for disorders of the cardiovascular system
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• A61P 3/00 - Drugs for disorders of the metabolism
• A61P 35/00 - Antineoplastic agents
• C12N 15/12 - Genes encoding animal proteins
• C12N 15/70 - Vectors or expression systems specially adapted for E. coli
• C12N 1/21 - BacteriaCulture media therefor modified by introduction of foreign genetic material
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61P 3/04 - AnorexiantsAntiobesity agents
• A61P 3/06 - Antihyperlipidemics
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

The present disclosure provides a random matrix vector multiply-add operation system and an operation method thereof. The operation system comprises an input bit stream generation unit, a weighting bit stream generation unit and a memory array; the input bit stream generation unit is used for generating, according to preset input vectors, pulse sequences of corresponding input random bit streams, and the weighting bit stream generation unit is used for generating, according to a preset weighting matrix, pulse sequences of corresponding weighting random bit streams, the pulse sequences of the input random bit streams and the pulse sequences of the weighting random bit streams being respectively applied to word lines and bit lines of the memory array; multiply-add results of the input random bit streams and the weighting random bit streams at memory devices of the memory array are stored in conductivity values of the corresponding memory devices. The random matrix vector multiply-add operation system and the operation method thereof provided by the present disclosure can solve the problems of low operation speed, low parallel degree and large hardware overheads of traditional multiply-add computing units in stochastic computing.

IPC Classes  ?

• G06F 7/544 - Methods or arrangements for performing computations using exclusively denominational number representation, e.g. using binary, ternary, decimal representation using non-contact-making devices, e.g. tube, solid state deviceMethods or arrangements for performing computations using exclusively denominational number representation, e.g. using binary, ternary, decimal representation using unspecified devices for evaluating functions by calculation

Abstract

A thermochromic cholesteric liquid crystal material, which is formed by mixing a parent liquid crystal and a chiral agent, wherein the parent liquid crystal comprises a mixture A and a mixture B, which are both hydrogen bond liquid crystals, wherein the mixture A has a clearing point of 120ºC to 180ºC, and is a mixture of at least two benzoic acid derivatives; and the mixture B has a crystallization point of -30ºC to 0ºC, and is a mixture of at least two cyclohexanecarboxylic acid derivatives. The cholesteric liquid crystal material of the present invention has the characteristics of high sensitivity and a wide color gamut, can achieve continuous change of a structural color from red to blue within a very narrow temperature interval, and can optimally achieve the change of the structural color from red to blue within 3-5ºC, which is more sensitive than a traditional cholesteric liquid crystal; moreover, the cholesteric liquid crystal material has a wide color change range, and has large application potential in the aspects of temperature display, anti-counterfeiting techniques, etc.

IPC Classes  ?

• C09K 9/02 - Organic tenebrescent materials
• C09K 19/36 - Steroidal liquid crystal compounds

Abstract

The present application provides a two-dimensional network-on-chip structure, a routing method therefor, an apparatus, a device, and a storage medium, and relates to the technical field of communication. The two-dimensional network-on-chip structure comprises: a plurality of processing cores, any one of the processing cores comprising a routing node, the routing node comprising five input distributors and five output arbiters; any one of the input distributors is used for sending to a target output arbiter a target data packet transmission request, the target output arbiter is determined on the basis of a target routing direction, and the target routing direction is determined on the basis of destination address information of the target data packet and an X/Y-dimension sequence routing policy; the target output arbiter is used for responding to the transmission request so as to transmit the target data packet to a target position corresponding to the target output arbiter, the target position comprising one of four adjacent routing nodes or a pulse data packet encoding and decoding interface. The present application avoids deadlocks and increases the throughput of the two-dimensional network-on-chip structure.

IPC Classes  ?

• H04L 49/112 - Switch control, e.g. arbitration

Abstract

Provided in the present application are a biological credible neuron calculation circuit and a calculation method. The circuit carries out an operation on a membrane level and a neural network pulse signal at the previous moment by means of a synaptic integration module, a leakage integration module, and a threshold comparison and pulse firing module, so as to acquire a membrane level at the current moment, and generate a pulse signal according to the membrane level at the current moment. Compared with a conventional digital-analog hybrid design which excessively pursues accurate neuromorphic behaviors, and a conventional digital design which excessively pursues extremely low calculation complexity, the biological credible neuron calculation circuit in the present application makes a better compromise between biological confidence and calculation complexity, such that richer neuron dynamics behaviors can be realized at a relatively low hardware cost, the maximum-scale enhancement of LIF neuron integration and synaptic integration is realized, and more complex and more diverse neuromorphic brain-like applications can be deployed.

IPC Classes  ?

• G06N 3/06 - Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons

Abstract

Provided in the present application are a brain-like synaptic learning method, and a neuromorphic hardware system based on a brain-like technique. The method comprises: determining a spike pair generated by means of a pre-synaptic neuron and post-synaptic neuron in a brain-like synaptic learning circuit, wherein the spike pair comprises an input spike generated by means of the pre-synaptic neuron and an output spike generated by means of the post-synaptic neuron; on the basis of the spike pair, determining an STDP mechanism corresponding to the spike pair, and a synaptic weight corresponding to the STDP mechanism; and on the basis of the spike pair and the synaptic weight, performing STDP learning corresponding to the brain-like synaptic learning circuit, wherein the STDP mechanism is a spike-timing-dependent plasticity mechanism, and a pre-synaptic spike and post-synaptic spike of the spike pair correspond to a long-term potentiation process or long-term depression process in the STDP mechanism according to a time order relationship. By means of the present application, online learning of brain-like intelligence is improved, and the environmental adaptation characteristic of brain-like computing being widely applicable is exploited.

IPC Classes  ?

• G06N 3/06 - Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons

Abstract

The present application provides a circuit of on-chip network and an electronic device. The circuit of on-chip network comprises a five-layer routing module circuit and a resource circuit. The routing module circuit comprises five routing layers. The resource circuit comprises a plurality of brain-like chip processing cores. Four routing nodes connected to a first routing layer in the routing module circuit to serve as a second routing layer; each routing node in the second routing layer is connected to four routing nodes to serve as a third routing layer; each routing node in the third routing layer is connected to four routing nodes to serve as a fourth routing layer; each routing node in the fourth routing layer is connected to four routing nodes to serve as a fifth routing layer; and each routing node in the fifth routing layer is connected to the four brain-like chip processing cores. Routing nodes closer to a root routing node have a larger number of parallel channels. According to the present application, excessive delay of the grid structure is avoided and the congestion problem of the circuit of on-chip network is alleviated.

IPC Classes  ?

• G06F 15/173 - Interprocessor communication using an interconnection network, e.g. matrix, shuffle, pyramid, star or snowflake

Abstract

The present application provides a digital neuromorphic computing processor and a computing method. The processor acquires neural network input data by means of a data packet routing module, a data caching module, a synaptic connection storage module, and a neuron computing module, so as to determine a neural network type of the neural network input data, then performs operation on an input pulse neural network pulse signal or an artificial neural network activation value according to a pre-stored neural network synaptic weight value and neuron parameters, and outputs an operation result according to the neural network type. Existing computational processors based on model conversion methods require model algorithm conversion, resulting in significant loss of precision. The present application can be applied to both pulse neural networks and artificial neural networks, and does not require model algorithm conversion, so that the loss of precision in a process of model conversion is avoided.

IPC Classes  ?

• G06N 3/063 - Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons using electronic means

Abstract

The present application provides a sparse spiking neural network accelerator based on a ping-pong architecture. Compressed weight values are transmitted to a compressed weight calculation module, and a sparse spike detection module is used for extracting an effective spike index from a spike input signal, thereby preventing subsequent spike signals from all participating in an operation, and reducing the amount of calculation; and the compressed weight calculation module accumulates a non-zero value among the compressed weight values to a membrane potential of a neuron according to the effective spike index, and finally decides whether to emit a spike or not. Compared with a traditional technical solution that all synapses in a synaptic crossbar array are activated and participate in an operation, in the present application, only a synaptic weight corresponding to the effective spike index is activated, and other synapses do not participate in the operation, thereby reducing the amount of calculation, reducing the operating power consumption of the whole chip, and improving the operating speed, energy efficiency and area efficiency of a spiking neural network.

IPC Classes  ?

• G06N 3/063 - Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons using electronic means

Abstract

A compute-in-memory (CIM) circuit and a control method thereof. The CIM circuit includes a memory array. The memory array comprises n1 memory blocks arranged in sequence from top to bottom, and each memory block comprises n2 rows of memory-cell rows arranged in sequence, wherein n1≥2, n2≥1. Each odd memory block and an adjacent even memory block arranged therebelow form a memory group. Each memory group comprises n2 pairs of memory-cell rows, and a k-th pair of memory-cell rows in each memory group includes a k-th memory-cell row and a (2n2+1−k)-th memory-cell row in the corresponding memory group, where 1≤k≤n2. The memory array is divided into n2 memory subarrays configured to be turned on in sequence for calculation, wherein a k-th memory subarray includes the k-th pair of memory-cell rows in each memory group.

IPC Classes  ?

• G11C 7/16 - Storage of analogue signals in digital stores using an arrangement comprising analogue/digital [A/D] converters, digital memories and digital/analogue [D/A] converters
• G11C 7/10 - Input/output [I/O] data interface arrangements, e.g. I/O data control circuits, I/O data buffers

Abstract

Provided in the present invention are an ASP-ELP for reducing immunogenicity and enhancing an anti-tumor effect, and a preparation method therefor and the use thereof. According to the present invention, for the first time, the artificial intelligence tool AlphaFold2 is used to fuse ELPs of different lengths and compositions with ASP. The designed ASP-ELPs have multiple advantages compared with bulk drug asparaginase ASP and long-acting asparaginase PEG-ASP. In vivo and in vitro experimental results show that the ASP-ELPs are superior to the long-acting asparaginase in the aspects of enzyme activity retention rate, storage stability, pharmacokinetics, immunogenicity, biosafety, anti-cancer efficacy, etc. The present invention not only provides a new design method for pharmaceutical research and development of a protein-macromolecular polymer on the basis of artificial intelligence-assisted design, but also shows that the ASP-ELPs are a new efficient therapy for treating hematological malignancies.

IPC Classes  ?

• A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
• C07K 19/00 - Hybrid peptides
• C12N 15/09 - Recombinant DNA-technology
• A61K 35/00 - Medicinal preparations containing materials or reaction products thereof with undetermined constitution

Abstract

The present application provides a weighted summation compute-in-memory circuit and a memory. The circuit is provided with a first array and a second array which are symmetrically distributed, and a peripheral circuit, wherein when the first array is used to perform compute-in-memory, firstly, the first array and the second array are disconnected by means of the peripheral circuit, and bitwise matrix vector multiplication is executed by means of the first array; and then, the first array and the second array are connected by means of the peripheral circuit, and the first array and the second array form a switched capacitor circuit, so as to acquire, by means of the second array, analog summation and analog weighted summation operations corresponding to pulse signals, and output operation results. By using the weighted summation compute-in-memory circuit and the memory, the voltage stability on a bit line can be maintained, and the number of times that an ADC is started is reduced, thereby improving the energy efficiency and area efficiency of a system.

IPC Classes  ?

• G06N 3/065 - Analogue means

Abstract

Provided is a genetically engineered nitrogen-fixing bacterium comprising conditionally activated ammonium excretion regulated by an environmental condition. Also provided is a composition comprising the bacterium as well as use of the bacterium or composition for providing fixed atmospheric nitrogen to crop plants in the fields.

IPC Classes  ?

• C12N 1/21 - BacteriaCulture media therefor modified by introduction of foreign genetic material
• C05F 11/08 - Organic fertilisers containing added bacterial cultures, mycelia or the like
• C12N 15/52 - Genes encoding for enzymes or proenzymes
• C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12R 1/19 - Escherichia coli
• C12R 1/22 - Klebsiella

Abstract

MEMEME has five cap modifications at each end of a full thio-sequence, and the carrier consists of a nucleoside phospholipid TPS or CPS, a cationic lipid CLDA and an auxiliary lipid DSPE-PEG. In the present invention, by means of adjusting the ratio in the preparation and optimizing the solvent of the preparation, a novel anti-liver cancer pharmaceutical preparation having a great clinical application potential is obtained. After low-dose and low-frequency intravenous administration to mice, the preparation significantly inhibits the growth of liver cancer in mice, and exhibits an ideal sustained-release/long-acting anti-cancer effect, with an efficacy superior to that of a CT102/DNCA/CLD/PEG preparation. The present invention establishes a foundation for the wide clinical application of anti-liver cancer antisense nucleic acid drugs, and also has wide application prospects in the field of gene therapy.

IPC Classes  ?

• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
• A61K 47/20 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
• A61P 35/00 - Antineoplastic agents
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Abstract

The present application provides a method for preventing metallic copper from corrosion and a metallic copper anti-corrosion structure, belonging to the technical field of metal anti-corrosion. The method for preventing metallic copper from corrosion comprises forming a graphene layer with a thickness of at least 2 atomic layers on a surface of a copper matrix. The method for preventing metallic copper from corrosion of the present application can weaken charge transfer between corrosive substances and the copper matrix by means of formation of the graphene layer with the thickness of at least 2 atomic layers on the surface of the copper matrix, so that the copper matrix is not prone to an electrochemical reaction via the graphene layer on the surface, thereby improving the anti-corrosion performance of the copper matrix.

IPC Classes  ?

• C23C 16/26 - Deposition of carbon only

Abstract

This invention relates to an unnatural amino acid-based ionic liquid, and preparation methods and applications thereof. It specifically provides a combination for preparing a protein comprising an unnatural amino acid, comprising: (1) one or more aminoacyl-tRNA synthetases capable of binding to a mutated tRNA; (2) one or more mutated tRNAs with an anti-codon loop mutated to complement a termination codon; (3) various unnatural amino acid-based ionic liquids. The combination can be used for recombinant expression of a target protein comprising an unnatural amino acid. The unnatural amino acid-based ionic liquids can improve the read-through efficiency of the genetic codon expansion system for a premature termination codon (PTC) and/or the incorporation efficiency of unnatural amino acids.

IPC Classes  ?

• C12P 21/00 - Preparation of peptides or proteins
• C12N 9/00 - Enzymes, e.g. ligases (6.)ProenzymesCompositions thereofProcesses for preparing, activating, inhibiting, separating, or purifying enzymes

Abstract

A chemiluminescent lateral flow immunoassay method is provided for reducing cross reactions and false positives when detecting protein analytes. The detection method involves a lateral flow immunoassay strip, the strip includes a sample pad, a conjugate pad, a nitrocellulose membrane, and an absorbent pad. The capture antibody of the analyte on the nitrocellulose membrane is used as the test line, and the IgG antibody is used as the control line. The lateral flow immunoassay is performed on the strip by the Au nanoparticle-antibody-horseradish peroxidase-polyethylene glycol (AuNP-Ab-RP-PEG) conjugate to detect the specific analyte. During the detection, the conjugate is prepared in the strip and then added to the analyte for detection, or the conjugate is mixed with the analyte and then added to the strip for detection.

IPC Classes  ?

• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 21/76 - ChemiluminescenceBioluminescence
• G01N 33/532 - Production of labelled immunochemicals

Abstract

A methane sensor includes a substrate, a conductive connection electrode, and a sensing electrode, the conductive connection electrode is arranged on the substrate, and the sensing electrode is covered on the conductive connection electrode, the sensing electrode is a layer of conductive polymer film, and the conductive connection electrode is coated with an insulating layer in addition to the sensing area. The sensing electrode adopts one of poly (3,4-ethylenedioxythiophene): poly (styrene sulfonic acid), polyaniline, polythiophene and polypyrrole, which is made into a film by a screen printing, inkjet printing or other coating method in the form of liquid or paste. The present invention adopts the above methane sensor, with a small and stable sensor, realizing sensitive and rapid detection of methane, and solving the problems of high power consumption of methane sensors in the prior art, high working temperature, expensive and bulky casing of the equipment, and high price.

IPC Classes  ?

• G01N 27/30 - Electrodes, e.g. test electrodesHalf-cells
• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups

Abstract

Provided is a composition used for obtaining and/or culturing a human intestinal tissue-derived organoid or a human colorectal tumor tissue-derived organoid, the composition comprising an ALK inhibitor, a WNT agonist, an EGF agonist, and an FGF agonist. Further provided is a composition used for obtaining and/or culturing an organoid having a proliferative intestinal crypt tissue feature and/or an "intermediate plastic state" cell, the composition comprising an ALK inhibitor, a WNT agonist, an EGF agonist, an EBP1 and IκB dual regulator, and a P38 inhibitor.

IPC Classes  ?

• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• C12N 5/09 - Tumour cells

Abstract

Provided is a composition for obtaining and/or culturing human normal-tissue-derived organoids or human tumor-tissue-derived organoids, the composition including ALK inhibitors (e.g., LDN214117), WNT agonists (e.g., CHIR), EGF agonists (e.g., EGF) and FGF agonists (e.g., FGF2), and optionally IKKε inhibitors.

IPC Classes  ?

• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• C12N 5/09 - Tumour cells
• C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving viable microorganisms

Abstract

A high-density ferroelectric memory, and a manufacturing method therefor and an application thereof, relating to the field of semiconductor memories. The memory consists of multiple memory cells arranged in an array, and two sides of the array of the memory cells are connected by substantially orthogonal word lines and bit lines. Each memory cell has a stack structure of a top electrode, a resistive dielectric layer, an intermediate metal layer, a ferroelectric dielectric layer, and a bottom electrode, and the structure is electrically equivalent to a ferroelectric capacitor and a resistive selector connected in series. By regulating the RC delay of the memory cells, the voltage distributed to a ferroelectric capacitor in an unselected cell is reduced, so that the disturbance to the unselected cell is reduced; additionally, the capacitance value of the ferroelectric capacitor is stable, and the effect of a disturbance voltage can be effectively reduced by means of RC regulation. The present invention improves the memory window of a memory and reduces the bit error rate, without increasing additional area overhead.

IPC Classes  ?

• H10B 53/30 - Ferroelectric RAM [FeRAM] devices comprising ferroelectric memory capacitors characterised by the memory core region

Abstract

Provided are methods for editing RNA by introducing a deaminase-recruiting RNA in a host cell for deamination of an adenosine in a target RNA. Further provided are deaminase-recruiting RNAs used in the RNA editing methods and compositions and kits comprising the same.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61P 3/06 - Antihyperlipidemics
• C12N 9/00 - Enzymes, e.g. ligases (6.)ProenzymesCompositions thereofProcesses for preparing, activating, inhibiting, separating, or purifying enzymes
• C12N 9/80 - Hydrolases (3.) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides

Abstract

A high-speed and high-density ferroelectric memory, and a manufacturing method therefor and an application thereof, relating to the field of semiconductor memories. The memory consists of multiple memory cells arranged in an array, and two sides of the array of the memory cells are connected by substantially orthogonal word lines and bit lines. Each memory cell has a structure in which a top electrode, a variable capacitance dielectric layer, an intermediate metal layer, a ferroelectric dielectric layer, and a bottom electrode are stacked, and the structure is electrically equivalent to a ferroelectric capacitor and a variable capacitance selector connected in series. By regulating a voltage distribution relationship among the memory cells, the voltage distributed to a ferroelectric capacitor in an unselected cell is reduced, so that the disturbance to the unselected cell is reduced; additionally, the serial connection of capacitors reduces the RC delay of the memory cells and improves the memory access speed. Therefore, the present invention reduces the disturbance to an unselected cell, improves the memory window of a memory, reduces the bit error rate of the memory, and improves the memory access speed, without increasing additional area overhead.

IPC Classes  ?

• H10B 53/30 - Ferroelectric RAM [FeRAM] devices comprising ferroelectric memory capacitors characterised by the memory core region
• H10B 53/10 - Ferroelectric RAM [FeRAM] devices comprising ferroelectric memory capacitors characterised by the top-view layout
• H10N 97/00 - Electric solid-state thin-film or thick-film devices, not otherwise provided for
• G11C 11/22 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using electric elements using ferroelectric elements

Abstract

Provided in the present application are an end-edge-cloud coordination system and method based on a digital retina, and a device. The coordination system may include, but is not limited to, a front-end device, an edge device, and a cloud device. The front-end device is used for extracting, from collected video data, features having universality, and is used for generating analysis and recognition tasks on the basis of the features. The front-end device is also used for processing the analysis and recognition tasks, so as to obtain a first intermediate result to be sent to the edge device. The edge device is used for processing the analysis and recognition tasks on the basis of the first intermediate result, so as to obtain a second intermediate result to be sent to the cloud device. The cloud device is used for processing the analysis and recognition tasks on the basis of the second intermediate result, so as to obtain an analysis and recognition result for video data. By means of a coordination system architecture provided in the present application, computing coordination, feature coordination, and model coordination can be achieved. Therefore, the technical solution of the present application has the advantages of high efficiency, etc., and is well suited for processing a large amount of video data.

IPC Classes  ?

• G06V 10/44 - Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersectionsConnectivity analysis, e.g. of connected components
• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks

Abstract

Disclosed are an optical instrument, an imaging system, and an imaging method for a miniature multi-photon microscope, relating to the optical configuration field. The optical instrument is configured to have a fluorescence excitation optical path and a fluorescence collection optical path. The optical instrument includes a condenser, and the condenser includes a first lens group and a second lens group separately disposed. The first lens group is located in the fluorescence collection optical path, the second lens group is located in the fluorescence excitation optical path and the fluorescence collection optical path. A relative distance the second lens group and a miniature objective is less than a first preset distance threshold. A collection efficiency of scattered fluorescence of the miniature multi-photon microscope may be improved, thereby improving an imaging signal-to-noise ratio and an imaging depth when a sample to be test with a scattering characteristic is observed.

IPC Classes  ?

• G02B 21/00 - Microscopes
• G02B 21/08 - Condensers

Abstract

Disclosed is an embedded semiconductor random access memory structure, including a hafnium oxide-based ferroelectric storage element suitable for storing information, and a tunneling field effect transistor connected to the storage element. The tunneling field effect transistor is suitable for controlling the hafnium oxide-based ferroelectric storage element to perform read and write operations. A semiconductor memory array can be formed by repeating the above memory structures. A control method for the memory structure includes steps of writing 0, writing 1, reading, and writing back.

IPC Classes  ?

• H10B 53/30 - Ferroelectric RAM [FeRAM] devices comprising ferroelectric memory capacitors characterised by the memory core region
• G11C 11/22 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using electric elements using ferroelectric elements

Abstract

The industrial geographical information system relates to the field of industrial production intelligent management and control and comprises a device acquisition control end, a spatio-temporal big data processing end and an industrial geographical information system platform end. Based on a spatial data unified management and analysis framework of the geographic information system, various sensors, monitoring devices and mobile devices in an industrial production environment are acquired to perceive real-time data, and the real-time data are cleaned, denoised, cached, distributed, stored and processed permanently. Various types of static spatial data are import and entered, a composite spatio-temporal object model is employed to make macroscopic and microscopic visualization, collaborative processing update, spatio-temporal analysis and linkage analysis of industrial production scenes and processes, and collaborative joint control of industrial production processes and devices are conducted based on the device acquisition control end.

IPC Classes  ?

• G06F 16/24 - Querying
• G05B 19/406 - Numerical control [NC], i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to execute positioning, movement or co-ordinated operations by means of programme data in numerical form characterised by monitoring or safety
• G05B 19/4063 - Monitoring general control system
• G05B 19/409 - Numerical control [NC], i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to execute positioning, movement or co-ordinated operations by means of programme data in numerical form characterised by using manual data input [MDI] or by using control panel, e.g. controlling functions with the panelNumerical control [NC], i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to execute positioning, movement or co-ordinated operations by means of programme data in numerical form characterised by control panel details or by setting parameters
• G06F 16/2458 - Special types of queries, e.g. statistical queries, fuzzy queries or distributed queries
• G06F 16/29 - Geographical information databases

Abstract

segmentsegment segments, inserts a deterministic reset-probabilistic set pulse pair at a starting end position of each pulse sequence segment or inserts a probabilistic reset pulse at the starting position of each pulse sequence segment, and inserts a deterministic set pulse at a tail end position of each pulse sequence segment, so as to fix a pulse condition. Since the device can be reset/set at random in the nonvolatile resistive switching mode, a random bit stream correspondingly generated by each pulse sequence segment will be set to 0 at random, thus generating random bit streams which are mutually independent of and uncorrelated with each other and have adjustable probabilities.

IPC Classes  ?

• G06F 7/70 - Methods or arrangements for performing computations using a digital non-denominational number representation, i.e. number representation without radixComputing devices using combinations of denominational and non-denominational quantity representations using stochastic pulse trains, i.e. randomly occurring pulses the average pulse rates of which represent numbers

Abstract

Embodiments of the present application relate to the technical field of computers, and provide a method for generating a document improvement suggestion, and a device and a storage medium. The method comprises: acquiring a visual feature vector and a text feature vector of a document to be detected, and inputting the visual feature vector and the text feature vector into a preset document quality detection model to generate a document quality detection result (S101); when the document quality detection result does not meet standards, according to the visual feature vector, the text feature vector and the preset document quality detection model, determining at least one target feature used for improving the document quality of said document (S102); and according to the at least one target feature, acquiring a modification suggestion matching said document (S103).

IPC Classes  ?

• G06F 40/253 - Grammatical analysisStyle critique
• G06F 40/284 - Lexical analysis, e.g. tokenisation or collocates
• G06F 40/289 - Phrasal analysis, e.g. finite state techniques or chunking
• G06Q 10/10 - Office automationTime management
• G06N 3/08 - Learning methods

Abstract

Provided in the embodiments of the present application are a target discovery method based on metadynamics, and a related apparatus, which are applied to the fields of biology, medicine and drug design. The method comprises: performing dynamics simulation on a ligand structure and a receptor structure, such that the ligand structure traverses the surface of the receptor structure during a dynamics simulation process; determining target information of binding sites of the ligand structure on the surface of the receptor structure; and determining pocket information of the receptor structure according to a ranking output of the target information of the binding sites. During this process, a plurality of binding sites can be obtained by means of one instance of traversal, such that the range of a receptor conformation search can be wider, and the calculation amount is reduced, thereby improving the discovery efficiency of the binding sites.

IPC Classes  ?

• G16B 15/30 - Drug targeting using structural dataDocking or binding prediction
• G16C 10/00 - Computational theoretical chemistry, i.e. ICT specially adapted for theoretical aspects of quantum chemistry, molecular mechanics, molecular dynamics or the like

Abstract

Methods and systems for image processing are provided. The method may include obtaining image data generated by an image acquisition device; generating a preliminary image by processing the image data; and generating a target image by using an image processing model to process the preliminary image according to an optimization algorithm. The image processing model includes a first sub-model and a second sub-model. The first sub-model is configured to determine a first optimization term related to a likelihood term of an objective function, and the second sub-model is configured to determine a second optimization term related to a regularization term of the objective function, wherein the second sub-model is a trained machine-learning model.

IPC Classes  ?

• G06T 5/00 - Image enhancement or restoration

Abstract

A method of solving a partial differential equation based on a non-volatile memory array includes converting a to-be-solved partial differential equation into an iterative relation, selecting a reusable sub-matrix cell from the iterative coefficient matrix, and storing the sub-matrix cell in the memory array, extracting an input vector from the iteration vector, inputting the input vector into the memory array, updating a portion of the iteration vector by adding an obtained output vector to a portion of the constant vector, extracting the input vector from an updated iteration vector again, and inputting the input vector into the memory array until all elements of the iteration vector are updated to obtain an iteration vector for a next iteration, and ending the iteration when a preset number of iterations is reached or an error is less than a preset range.

IPC Classes  ?

• G06F 17/13 - Differential equations

Abstract

The present disclosure provides a method and a system for efficient and selective recovery of a ferric phosphate product from a leachate. The method includes the following steps: adjusting a pH value of a phosphorus-containing leachate to obtain an acidic phosphorus-containing leachate, heating the acidic phosphorus-containing leachate, adding an iron salt to precipitate a phosphorus element in the acidic phosphorus-containing leachate in the form of a ferric phosphate hydrate, and recovering an obtained ferric phosphate hydrate precipitate. In the present disclosure, production of a phosphorus product requires a certain amount of iron element added into the leachate. Iron widely distributed on the earth is low in cost and easily available, thereby facilitating large-scale applications of the method. An initial leachate after acid leaching shows acidic, and only a slight pH adjustment is required to achieve a target pH value of the leachate.

IPC Classes  ?

• C01B 25/37 - Phosphates of heavy metals

Abstract

The present disclosure provides a data processing method and apparatus applied to an in-memory computing chip, and a device. The data processing method comprises: converting current input data into current target data; in response to said current target data, performing weight distribution conforming to set weight distribution rules on a plurality of convolutional layers corresponding to the in-memory computing chip on the basis of a standard convolutional layer; and in response to the weight distribution, performing convolution processing in parallel on the current target data by means of the plurality of convolutional layers. As a consequence, on the basis of the described data processing, the time utilization of non-volatile memory can be remarkably improved, thereby implementing in-memory computing chips having a super-pipeline design in-memory computing architecture, and greatly increasing the throughput of non-volatile memory-based in-memory computing accelerators.

IPC Classes  ?

• G06F 17/15 - Correlation function computation
• G06F 17/16 - Matrix or vector computation
• G06N 3/063 - Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons using electronic means
• G06N 3/0464 - Convolutional networks [CNN, ConvNet]

Abstract

Systems and methods for image processing are provided in the present disclosure. The systems may obtain a first image and a second image associated with a same object; determine a plurality of first blocks of the first image and a plurality of second blocks of the second image, the plurality of second blocks and the plurality of first blocks being in one-to-one correspondence; determine a plurality of first characteristic values based on the plurality of first blocks and the plurality of second blocks; and/or generate a first target map associated with the first image and the second image based on the plurality of first characteristic values.

IPC Classes  ?

• G06T 5/50 - Image enhancement or restoration using two or more images, e.g. averaging or subtraction
• G06T 3/40 - Scaling of whole images or parts thereof, e.g. expanding or contracting
• G06T 5/20 - Image enhancement or restoration using local operators
• G06T 7/11 - Region-based segmentation

Abstract

A memristor-based in-memory logic circuit and in-memory logic computation system, and applications, pertaining to the technical field of integrated circuits, are provided. The in-memory logic circuit includes: a first memory cell and a second memory cell connected in parallel to each other, and a sense amplifier for generating a logic operation result. The two memory cells include memristors and MOSFET selectors connected in series. Resistance states of the two memristors are used to represent a first group of logic input signals, and voltage signals applied by gates of the two MOSFET selectors are used to represent a second group of logic input signals. Also provided are an in-memory logic computation system and applications.

IPC Classes  ?

• G11C 11/4091 - Sense or sense/refresh amplifiers, or associated sense circuitry, e.g. for coupled bit-line precharging, equalising or isolating
• G11C 11/408 - Address circuits
• G11C 11/4096 - Input/output [I/O] data management or control circuits, e.g. reading or writing circuits, I/O drivers or bit-line switches

Abstract

Methods and systems for image processing are provided. The method may include obtaining image data generated by an image acquisition device; generating a preliminary image by processing the image data; and generating a target image by using an image processing model to process the preliminary image according to an optimization algorithm. The image processing model includes a first sub-model and a second sub-model. The first sub-model is configured to determine a first optimization term related to a likelihood term of an objective function, and the second sub-model is configured to determine a second optimization term related to a regularization term of the objective function, wherein the second sub-model is a trained machine-learning model.

IPC Classes  ?

• G06T 7/00 - Image analysis
• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks

Abstract

A vertical photo-assisted metal-organic chemical vapor deposition (MOCVD) device and a deposition method thereof. A light field vertically acts on a layered reactant gas stream, such that an action path between the light field and the reactant gas stream is short, thereby reducing the required laser power, reducing the design difficulty of the photo-assisted MOCVD device, and improving the safety, and also reducing the propagation process of the light field in an MOCVD gas field, and improving the utilization efficiency of the power of the light field. By means of the rotation and revolution of a growth substrate along with a substrate tray, an active reactant generated by the light field is uniformly obtained between growth substrates in a growth cavity and inside each growth substrate, thereby realizing the large-size IE high-uniformity photo-assisted MOCVD epitaxial growth; and a generation process of a photo-generated reactant and a chemical vapor deposition process of the photo-generated reactant are separated in space, thereby simplifying the light field-flow field-temperature field coupling design in the photo-assisted MOCVD device.

IPC Classes  ?

• C30B 25/12 - Substrate holders or susceptors
• C30B 25/14 - Feed and outlet means for the gasesModifying the flow of the reactive gases

Abstract

This disclosure provides methods for converting 5-hydroxymethylcytosine (5hmC) to 5-formylcytosine (5fC) in a nucleic acid and methods for converting 5fC to 5-carboxylcytosine (5caC) in a nucleic acid. The disclosure further provides methods for identifying the locations of 5hmC in a nucleic acid sequence comprising the methods for converting 5hmC to 5fC and/or the methods for converting 5fC to 5caC.

IPC Classes  ?

• C12Q 1/6827 - Hybridisation assays for detection of mutation or polymorphism
• C12Q 1/6869 - Methods for sequencing

Abstract

The present application relates to an electron beam ionization ionic wind device, comprising a vacuum chamber, an electron source, an electron beam acceleration electrode, an electron beam exit window and an ion acceleration electrode, wherein the electron source is located inside the vacuum chamber, and is used for generating an electron beam; the electron beam acceleration electrode is located inside the vacuum chamber, or on a wall of the vacuum chamber, or outside the vacuum chamber, and is used for accelerating the electron beam; the electron beam exit window is located on the wall of the vacuum chamber, the electron beam exiting through the electron beam exit window to the outside of the vacuum chamber, so as to ionize gas molecules outside the vacuum chamber or adhere to the gas molecules to form ions; and the ion acceleration electrode is located outside the vacuum chamber, and is used for accelerating the ions to generate ionic wind.

IPC Classes  ?

• H01T 23/00 - Apparatus for generating ions to be introduced into non-enclosed gases, e.g. into the atmosphere

Abstract

Provided are a method for detecting nucleic acid sites edited by a base editor, and a kit for implementing the method. Also provided is a method for detecting the editing efficiency or off-target effects of the base editor editing nucleic acids.

IPC Classes  ?

• C12Q 1/6869 - Methods for sequencing
• C12Q 1/44 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase involving esterase
• C12Q 1/48 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving transferase

Abstract

A method for initiating the polymerization of amino acid N-carboxyanhydrides in the water phase, that is, a method for polymerizing amino acid N-carboxyanhydrides, which comprises adding, in the presence of an initiator, one or more amino acid N-carboxyanhydrides in a mixed solution of water or water and an organic solvent for reaction to produce a polyamino acid. The initiator is used to initiate the polymerization of the amino acid N-carboxyanhydrides to generate a polyamino acid, and the organic solvent is selected from among the following group: acetonitrile, pyridine, N,N-dimethylformamide, tetrahydrofuran or dimethylsulfoxide. The described method can produce a polyamino acid in a short period of time at a high yield and by using a means in which polymerization can be controlled, and can be used to prepare a conjugate of functional molecules, such as proteins, polypeptides, drugs, and fluorescent dyes, and a polyamino acid.

IPC Classes  ?

• A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
• A61P 35/00 - Antineoplastic agents

Abstract

A method for screening a drug for a tumor disease, a program product, a high-content imaging analysis system, and a method for analyzing phase separation conditions. The method comprises: seeding cells comprising a target fusion protein into a well plate comprising a well array, the target fusion protein being associated with a target tumor disease, comprising PS and DBD, and comprising a labeling molecule, so as to form aggregates that can be identified by imaging; distributing multiple types of small molecule compounds into individual wells; using a microscopic imaging system to continuously photograph each well in a plurality of different fields of view within a predetermined period of time to generate time-series images of the plurality of fields of view; on the basis of the foregoing, analyzing the amount attenuation condition of intracellular aggregates in each well; and screening out the wells of which the attenuation condition of the amount of intracellular aggregates meets a predetermined condition, and using correspondingly assigned small molecule compounds as drug candidates for the target tumor disease. Thus, the dynamic effects of a large number of different small molecules with respect to aggregates can be continuously and comprehensively monitored at a high throughput, and drug candidates can be efficiently and accurately screened out.

IPC Classes  ?

• C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving viable microorganisms
• G01N 21/84 - Systems specially adapted for particular applications
• G01N 21/01 - Arrangements or apparatus for facilitating the optical investigation

Abstract

The present invention relates to a wire bonding structure with an embedded manifold type micro-channel. The wire bonding structure includes: a chip, including a substrate and an embedded micro-channel located on a back portion of the substrate; an interposer, including a manifold channel, a liquid inlet, and a liquid outlet; a low-temperature sealing layer, configured to hermetically communicate the embedded micro-channel with the manifold channel, wherein the low-temperature sealing layer is located between the chip and the interposer; and a bonding wire, configured to electrically connect the chip to the interposer. The present invention further relates to a preparation method of a wire bonding structure with an embedded manifold type micro-channel. The wire bonding structure of the present invention has both low-temperature process compatibility and packaging compatibility, and further has high heat dissipation efficiency. The embedded manifold type micro-channel of the present invention has the advantages of short flow distance, low flow resistance, and low thermal resistance, and is more suitable for being integrated into a high-power chip for efficient heat dissipation.

IPC Classes  ?

• H01L 23/473 - Arrangements for cooling, heating, ventilating or temperature compensation involving the transfer of heat by flowing fluids by flowing liquids
• H01L 21/48 - Manufacture or treatment of parts, e.g. containers, prior to assembly of the devices, using processes not provided for in a single one of the groups or
• H01L 23/00 - Details of semiconductor or other solid state devices

Abstract

Disclosed is a method for preparing a nitride light emitting diode (LED) and nondestructive interface separation. A two-dimensional atomic crystal layer on a transparent substrate is modified by using an atomic irradiation technology, to obtain an irradiated region; a nitride LED structure is prepared on a modified two-dimensional atomic crystal layer, and a support substrate is cured by means of a metal functional layer; visible laser is incident from a back surface of the transparent substrate to directionally destruct the irradiated region of the two-dimensional atomic crystal layer, so as to obtain a whole structure of the nitride LED structure, the metal functional layer and the support substrate that are separated from the transparent substrate. The present disclosure can nondestructively separate the interface and repeatedly use the transparent substrate.

IPC Classes  ?

• H01L 33/00 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof
• H01L 27/15 - Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including semiconductor components with at least one potential-jump barrier or surface barrier, specially adapted for light emission

Abstract

Provided are a recombinant chimeric antigen for a poxvirus, in particular for a Mpoxvirus, a subunit vaccine comprising the recombinant chimeric antigen, and a use thereof. The recombinant chimeric antigen of the present application comprises two immunogens arranged in a specific manner: a Mpoxvirus A35 protein or an antigenic fragment thereof or derivative peptides of same, and a Mpoxvirus M1 protein or an antigenic fragment thereof or derivative peptides of same, and can excite an immune response to two infectious virus particles of intracellular mature virus (IMV) particles and extracellular enveloped virus (EEV) particles.

IPC Classes  ?

• C07K 14/065 - Poxviridae, e.g. avipoxvirus
• A61K 39/275 - Poxviridae, e.g. avipoxvirus
• A61P 31/12 - Antivirals
• C12N 15/39 - Poxviridae, e.g. vaccinia virus, variola virus
• C07K 19/00 - Hybrid peptides
• C12N 15/62 - DNA sequences coding for fusion proteins
• A61P 31/20 - Antivirals for DNA viruses

Abstract

An orthogonal alphavirus RNA replication system, i.e., an RNA replicase-assisted continuous in vivo evolution (REPLACE) system, and an REPLACE method. An RNA-based evolution element makes REPLACE of mammalian cells possible. According to the method, more than one billion replicable RNA copies can be continuously diversified and selected, and RNA replication and powerful inducible RNA mutation by means of replicase restriction are achieved. According to the method, new functions of fluorescent proteins, transcription factors and miniature Cas proteins (dCasMINI) are evolved or existing functions are improved. Cells equipped with REPLACE can adapt to challenges from the exterior or interior of the cells by continuously evolving the replicable RNA carrying cancer-related key genes (i.e., MEK1 and KRAS). An RNA-based evolution platform will provide a new high-performance tool kit for mammalian synthetic biology, and assist in adaptive engineering modification of mammalian cells and tissues.

IPC Classes  ?

• C12N 15/40 - Proteins from RNA viruses, e.g. flaviviruses
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• A61K 39/12 - Viral antigens
• A61P 31/14 - Antivirals for RNA viruses