Abrégé

Provided are methods of treating a disease or condition by administering a circular RNA (circRNA) encoding a therapeutic polypeptide (e.g., an antigenic polypeptide, a functional protein, a receptor protein, or a targeting protein (e.g., antibody)), wherein the circRNA is naked; and pharmaceutical composition(s) comprising the circRNA(s) as disclosed herein.

Classes IPC  ?

• A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
• A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
• A61K 38/39 - Peptides du tissu connectif, p. ex. collagène, élastine, laminine, fibronectine, vitronectine, globuline insoluble à froid [CIG]
• A61K 38/45 - Transférases (2)
• A61K 38/46 - Hydrolases (3)
• A61K 38/47 - Hydrolases (3) agissant sur des composés glycosyliques (3.2), p. ex. cellulases, lactases
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61K 39/215 - Coronaviridae, p. ex. virus de la bronchite infectieuse aviaire
• A61P 37/04 - Immunostimulants

Abrégé

Provided in the present application are a nonvolatile semiconductor memory and a preparation method. The memory comprises a substrate, and a control gate and a storage gate, which are sequentially arranged on the substrate, wherein a source electrode and a drain electrode are arranged on the substrate, and a channel that separates the source electrode from the drain electrode is formed in a substrate region located between the source electrode and the drain electrode; a ferroelectric layer is arranged between the channel and the storage gate, and the storage gate is used for applying a voltage to the upper surface of the ferroelectric layer, so as to change the polarization state of the ferroelectric layer; the control gate is used for controlling the channel to turn on or turn off; and writing, reading and erasing of data are realized by means of controlling the voltages of the storage gate, the source electrode, the control gate and the drain electrode.

Classes IPC  ?

• H10B 51/30 - Dispositifs de RAM ferro-électrique [FeRAM] comprenant des transistors ferro-électriques de mémoire caractérisés par la région noyau de mémoire
• H01L 29/78 - Transistors à effet de champ l'effet de champ étant produit par une porte isolée
• H01L 21/336 - Transistors à effet de champ à grille isolée

Abrégé

The present application provides a nonvolatile memory and a preparation method. The memory comprises a substrate, and a source side control gate, a storage gate, and a drain side control gate which are sequentially arranged above the substrate, wherein a source and a drain are arranged on the substrate, and a channel for isolating the source from the drain is formed in a substrate area between the source and the drain; a ferroelectric layer is arranged between the channel and the storage gate, and the storage gate is used for applying a voltage to the upper surface of the ferroelectric layer to change the polarization state of the ferroelectric layer; the source side control gate and the drain side control gate are used for controlling the opening or closing of the channel; data writing, reading and erasing are realized by controlling voltages of the storage gate, the source, the source side control gate, the drain side control gate, and the drain.

Classes IPC  ?

• H10B 51/30 - Dispositifs de RAM ferro-électrique [FeRAM] comprenant des transistors ferro-électriques de mémoire caractérisés par la région noyau de mémoire
• H01L 29/78 - Transistors à effet de champ l'effet de champ étant produit par une porte isolée

Abrégé

A nucleic acid molecule that regulates gene expression using an RNA splicing modulator, a nucleic acid construct containing an alternative splicing regulatory element and a target gene located at the 3' end of the alternative splicing regulatory element, a transcript of the nucleic acid construct under different conditions, and a vector, recombinant virus, cell and pharmaceutical composition containing the nucleic acid construct or the transcript, a method for regulating the expression level of a target gene by using same, and the use thereof in gene therapy.

Classes IPC  ?

• C12N 15/09 - Technologie d'ADN recombinant
• C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteursVecteurs Utilisation d'hôtes pour ceux-ciRégulation de l'expression
• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens

Abrégé

The present disclosure provides a video processing method, apparatus and electronic device. The method includes: acquiring a first video; processing the first video based on a video processing model to obtain a second video, wherein a training stage of the video processing model includes a differentiable encoder which is configured to simulate quantization and encoding processes performed by an encoder on a video, and the differentiable encoder is capable of performing gradient backpropagation; and encoding the second video.

Classes IPC  ?

• H04N 19/149 - Débit ou quantité de données codées à la sortie du codeur par estimation de la quantité de données codées au moyen d’un modèle, p. ex. un modèle mathématique ou un modèle statistique
• H04N 19/107 - Sélection du mode de codage ou du mode de prédiction entre codage prédictif spatial et temporel, p. ex. rafraîchissement d’image
• H04N 19/119 - Aspects de subdivision adaptative, p. ex. subdivision d’une image en blocs de codage rectangulaires ou non
• H04N 19/124 - Quantification
• H04N 19/13 - Codage entropique adaptatif, p. ex. codage adaptatif à longueur variable [CALV] ou codage arithmétique binaire adaptatif en fonction du contexte [CABAC]
• H04N 19/154 - Qualité visuelle après décodage mesurée ou estimée de façon subjective, p. ex. mesure de la distorsion
• H04N 19/159 - Type de prédiction, p. ex. prédiction intra-trame, inter-trame ou de trame bidirectionnelle
• H04N 19/176 - Procédés ou dispositions pour le codage, le décodage, la compression ou la décompression de signaux vidéo numériques utilisant le codage adaptatif caractérisés par l’unité de codage, c.-à-d. la partie structurelle ou sémantique du signal vidéo étant l’objet ou le sujet du codage adaptatif l’unité étant une zone de l'image, p. ex. un objet la zone étant un bloc, p. ex. un macrobloc
• H04N 19/503 - Procédés ou dispositions pour le codage, le décodage, la compression ou la décompression de signaux vidéo numériques utilisant le codage prédictif mettant en œuvre la prédiction temporelle
• H04N 19/593 - Procédés ou dispositions pour le codage, le décodage, la compression ou la décompression de signaux vidéo numériques utilisant le codage prédictif mettant en œuvre des techniques de prédiction spatiale
• H04N 19/61 - Procédés ou dispositions pour le codage, le décodage, la compression ou la décompression de signaux vidéo numériques utilisant un codage par transformée combiné avec un codage prédictif
• H04N 19/85 - Procédés ou dispositions pour le codage, le décodage, la compression ou la décompression de signaux vidéo numériques utilisant le pré-traitement ou le post-traitement spécialement adaptés pour la compression vidéo

Abrégé

The present disclosure provides a complementary phototransistor pixel unit, a sensing and computing array structure and an operation method thereof. The complementary phototransistor pixel unit includes: a first photoelectric field effect transistor, which is a photoelectric field effect transistor based on an ultra-thin body and buried oxide layer; and a second photoelectric field effect transistor, the second photoelectric field effect transistor is a photoelectric field effect transistor based on an ultra-thin body and buried oxide layer, each of the first photoelectric field effect transistor and the second photoelectric field effect transistor is four-end device and has a gate electrode G, a source electrode S, a drain electrode D, and a well base electrode B, and the source electrode S or drain electrode D of the first photoelectric field effect transistor is connected to the source electrode S or drain electrode D of the second photoelectric field effect transistor.

Classes IPC  ?

• G11C 13/04 - Mémoires numériques caractérisées par l'utilisation d'éléments d'emmagasinage non couverts par les groupes , ou utilisant des éléments optiques
• H10B 99/00 - Matière non prévue dans les autres groupes de la présente sous-classe
• H10F 30/282 - Transistors à effet de champ à grille isolée [IGFET], p. ex. phototransistors MISFET [transistor à effet de champ métal-isolant-semi-conducteur]

Abrégé

Provided in the present disclosure are a method for preparing a self-aligned transistor, a self-aligned transistor, a device and an apparatus. The method comprises: forming a hard mask and a side wall structure on a channel region of a substrate; etching the substrate on the basis of the hard mask and the side wall structure, so as to form a first semiconductor structure; removing the hard mask, and etching the first semiconductor structure and the substrate, so as to form a first active structure and a second active structure, wherein the first active structure comprises at least two fins corresponding to the side wall structure; epitaxially growing a first source structure or a first drain structure in an active region at either end of the first active structure, so as to form a first transistor, wherein the first transistor is a fin field effect transistor; and chamfering the substrate, and removing the substrate, so as to expose the second active structure; and epitaxially growing a second source structure or a second drain structure in an active region at either end of the second active structure, so as to form a second transistor, wherein the second transistor is a nanosheet field effect transistor or a planar transistor.

Classes IPC  ?

• H01L 21/8238 - Transistors à effet de champ complémentaires, p.ex. CMOS
• H01L 21/8234 - Technologie MIS
• H01L 27/088 - Dispositifs consistant en une pluralité de composants semi-conducteurs ou d'autres composants à l'état solide formés dans ou sur un substrat commun comprenant des éléments de circuit passif intégrés avec au moins une barrière de potentiel ou une barrière de surface le substrat étant un corps semi-conducteur comprenant uniquement des composants semi-conducteurs d'un seul type comprenant uniquement des composants à effet de champ les composants étant des transistors à effet de champ à porte isolée
• H01L 27/092 - Transistors à effet de champ métal-isolant-semi-conducteur complémentaires
• H05K 1/18 - Circuits imprimés associés structurellement à des composants électriques non imprimés
• B82Y 10/00 - Nanotechnologie pour le traitement, le stockage ou la transmission d’informations, p. ex. calcul quantique ou logique à un électron

Abrégé

A method, apparatus, and system for generating a local vibratory haptic feedback, and a computing device are provided. The method may comprise: on the basis of a target vibration position and a reference vibration field at the target vibration position, determining an intrinsic mode set and a reference mode participation coefficient set associated with a vibration patch; on the basis of the intrinsic mode set and the reference mode participation coefficient set, determining a target vibration field at the target vibration position; on the basis of the reference mode participation coefficient set, selecting an intrinsic mode subset for mode superposition and a mode participation coefficient subset corresponding to the intrinsic mode subset, wherein a superposed vibration field generated on the basis of the intrinsic mode subset and the mode participation coefficient subset corresponding to the intrinsic mode subset meets a preset similarity requirement with respect to the target vibration field; and on the basis of the intrinsic mode subset, the mode participation coefficient subset corresponding to the intrinsic mode subset, and the position of a vibration assembly, determining driving control information, wherein the driving control information is used for driving the vibration assembly to generate a local vibratory haptic feedback at the target vibration position.

Classes IPC  ?

• G06F 3/01 - Dispositions d'entrée ou dispositions d'entrée et de sortie combinées pour l'interaction entre l'utilisateur et le calculateur

Abrégé

Provided in the present disclosure are a semiconductor structure preparation method, a semiconductor structure, a semiconductor device, and a device. The method comprises: providing a substrate, which is a wafer; forming an active structure on the substrate, wherein the active structure comprises a first part and a second part; depositing a semiconductor material on the active structure, so as to form a dummy gate structure; forming a source structure and a drain structure of a first transistor on two sides of a third part of the dummy gate structure; flipping the wafer, and removing the substrate; forming a source structure and a drain structure of a second transistor on two sides of a fourth part of the dummy gate structure; etching the dummy gate structure, so as to form a first trench; and forming a first gate structure of the first transistor and a second gate structure of the second transistor, respectively, at the first trench, wherein the first gate structure and the second gate structure are self-aligned in a vertical direction.

Classes IPC  ?

• H01L 21/8234 - Technologie MIS
• H01L 27/088 - Dispositifs consistant en une pluralité de composants semi-conducteurs ou d'autres composants à l'état solide formés dans ou sur un substrat commun comprenant des éléments de circuit passif intégrés avec au moins une barrière de potentiel ou une barrière de surface le substrat étant un corps semi-conducteur comprenant uniquement des composants semi-conducteurs d'un seul type comprenant uniquement des composants à effet de champ les composants étant des transistors à effet de champ à porte isolée
• H01L 29/423 - Electrodes caractérisées par leur forme, leurs dimensions relatives ou leur disposition relative ne transportant pas le courant à redresser, à amplifier ou à commuter
• H01L 29/08 - Corps semi-conducteurs caractérisés par les formes, les dimensions relatives, ou les dispositions des régions semi-conductrices avec des régions semi-conductrices connectées à une électrode transportant le courant à redresser, amplifier ou commuter, cette électrode faisant partie d'un dispositif à semi-conducteur qui comporte trois électrodes ou plus

Abrégé

A method for identifying transformation products of antibiotics from known and potential unknown transformation pathways includes: step 1: collecting samples, extracting antibiotics and transformation products thereof, and obtaining non-target data by ultra-high performance liquid chromatography-high resolution mass spectrometry; step 2: identifying transformation products of antibiotics from known and unknown transformation pathways; step 3: generating a list of candidate transformation products and annotating their structures; step 4: extracting feature fragments based on structure annotations of the transformation products obtained in step 3, and searching for spectra with the feature fragment, and supplementing the transformation products from unknown transformation pathway; and step 5: obtaining a final list of identified products based on annotated structures.

Classes IPC  ?

• G16C 20/20 - Identification d’entités moléculaires, de leurs parties ou de compositions chimiques
• G01N 30/02 - Chromatographie sur colonne
• G01N 30/72 - Spectromètres de masse
• G01N 30/86 - Analyse des signaux

Abrégé

The present invention discloses a method and system for enhancing the accuracy of point cloud classification in the spectral domain, relating to the field of point cloud classification. The method comprises the following steps: acquiring original point cloud data of 3D objects; constructing a KNN graph on the original point cloud to represent the geometric structural information, wherein the KNN graph transforms the original point cloud data from the data domain to the spectral domain using GFT; constructing spectral filters to filter the spectral features of the data transformed to the spectral domain, generating perturbed spectral signals; reverting the perturbed spectral signals back to the data domain through GFT, obtaining adversarial point cloud data; generating samples based on the original point cloud data and adversarial samples based on the adversarial point cloud data, serving as training data, and inputting them into the point cloud classification model for classification training; using the trained point cloud classification model to classify the original point cloud data of the target 3D object and producing a classification result. This invention can enhance the accuracy of point cloud classification and recognition by the model.

Classes IPC  ?

• G06V 10/764 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant la classification, p. ex. des objets vidéo
• G06T 5/10 - Amélioration ou restauration d'image utilisant le filtrage dans le domaine non spatial
• G06T 5/20 - Amélioration ou restauration d'image utilisant des opérateurs locaux
• G06T 17/00 - Modélisation tridimensionnelle [3D] pour infographie

Abrégé

Provided are an annular gate plasma transistor and a manufacturing method therefor. The annular gate plasma transistor comprises a source electrode layer (1), a gate electrode layer (2) and a drain electrode layer (3), wherein a first insulating layer (4) is provided between the gate electrode layer (2) and the drain electrode layer (3), and a second insulating layer (5) is provided between the source electrode layer (1) and the gate electrode layer (2); several through holes (20) are formed in a gate electrode of the gate electrode layer (2), the first insulating layer (4) and the second insulating layer (5) are of a hollow structure, and the hollow structure of the first insulating layer (4) is connected to the hollow structure of the second insulating layer (5) by means of the through holes (20), so that a closed chamber is formed between the source electrode layer (1) and the drain electrode layer (3), and a source electrode of the source electrode layer (1), the gate electrode of the gate electrode layer (2) and a drain electrode of the drain electrode layer (3) are exposed in the closed chamber; when the annular gate plasma transistor works, there are carriers in the closed cavity; and the movement trajectories of the carriers are regulated, so as to regulate an on-state current of the annular gate plasma transistor. The present disclosure has a relatively strong gate control capability.

Classes IPC  ?

• H01J 21/10 - Tubes à voie de décharge unique pourvus de moyens de commande exclusivement électrostatiques à une ou plusieurs électrodes de commande intérieures fixes, p. ex. triode, pentode, octode
• H01J 19/38 - Électrodes de commande, p. ex. grille
• H01J 19/54 - EnceintesRécipientsBlindages associés
• H01J 9/00 - Appareils ou procédés spécialement adaptés à la fabrication de tubes à décharge électrique, de lampes à décharge électrique ou de leurs composantsRécupération de matériaux à partir de tubes ou de lampes à décharge

Abrégé

The present disclosure provides a method for preparing a gallium nitride (GaN) single-crystal substrate with an edge metal mask technology. The method includes: preparing a metal mask ring on a composite epitaxial substrate, epitaxially growing a GaN single-crystal sacrificial layer in a confined manner, performing separation with interlayer decoupling of single-crystal graphene through an in-situ temperature gradient method to obtain a self-supporting GaN single-crystal sacrificial layer, epitaxially growing a GaN single-crystal thick film in a diameter expanded manner, and performing chemico-mechanical trimming on the GaN single-crystal thick film to obtain a stress-free self-supporting GaN single-crystal substrate. The metal mask ring is compatible with the GaN single-crystal preparation process (hydride vapor phase epitaxy (HVPE)), and efficiently catalyzes decomposition reaction of the nitrogen source. While prohibiting edge growth of the GaN single-crystal thick film, the present disclosure improves a crystalline quality of the GaN single-crystal substrate.

Classes IPC  ?

• C30B 29/40 - Composés AIII BV
• C30B 25/04 - Dépôt suivant une configuration déterminée, p. ex. en utilisant des masques
• C30B 25/08 - Enceintes de réactionEmploi d'un matériau spécifié à cet effet
• C30B 25/14 - Moyens d'introduction et d'évacuation des gazModification du courant des gaz réactifs
• C30B 25/16 - Commande ou régulation
• H01L 21/02 - Fabrication ou traitement des dispositifs à semi-conducteurs ou de leurs parties constitutives

Abrégé

Provided are circular RNAs (circRNAs) encoding an antigenic polypeptide of a SARS-CoV-2 variant. Provided are circRNA vaccines against a SARS-CoV-2 variant, such as a Delta or Omicron variant. The circRNA vaccine comprises a circRNA comprising a nucleic acid sequence encoding an antigenic polypeptide comprising a Spike(S) protein or a fragment thereof of a SRAS-CoV-2 variant. Also provided are methods of treating or preventing a SARS-CoV-2 infection using the circRNAs or compositions thereof.

Classes IPC  ?

• A61K 39/215 - Coronaviridae, p. ex. virus de la bronchite infectieuse aviaire
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61P 37/04 - Immunostimulants
• C07K 14/005 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de virus

Abrégé

A glycan, a preparation method therefor and a use thereof, and an anti-tumor drug, relating to the technical field of medicines. The glycan having a structure as shown in formula I has good anti-tumor activity and good safety. The results of the test example show that the glycan has a good proliferation inhibition effect on pancreatic cancer cells, has no cytotoxicity to the growth of hepatocytes, and shows better safety characteristics compared with a positive drug gemcitabine; in addition, the pancreatic cancer cells are sensitive to the glycan, thereby overcoming the problem that the pancreatic cancer cells have certain drug resistance to gemcitabine.

Classes IPC  ?

• C08B 37/00 - Préparation des polysaccharides non prévus dans les groupes Leurs dérivés
• A61K 31/715 - Polysaccharides, c.-à-d. ayant plus de cinq radicaux saccharide liés les uns aux autres par des liaisons glycosidiquesLeurs dérivés, p. ex. éthers, esters

Abrégé

Methods, compounds, and compositions for promoting cellular COPII condensation, regulating plasma lipid in a subject, or treating or preventing diseases, disorders or conditions related to or resulted from dyslipidemia, chylomicron retention disease, or symptoms thereof.

Classes IPC  ?

• A61K 33/32 - ManganèseSes composés
• A61P 3/06 - Antihyperlipémiants

Abrégé

Embodiments of the present application provides a method for improving the short-circuit capability of an enhancement-mode (E-mode) GaN HEMT and its device structure. This is achieved by depositing metal in the active region between the gate and the source, adjacent to the source region of a conventional E-mode GaN HEMT, the metal is directly connected with the source of the conventional E-mode GaN HEMT. The conventional E-mode GaN HEMT is combined with a gate-source-shorted depletion-mode (D-mode) GaN HEMT to form a complete E-mode GaN HEMT with improved short-circuit capability. By clamping the saturation current of the complete device through the D-mode GaN HEMT, the saturation current density of the E-mode GaN HEMT can be reduced, and the purpose of improving the short-circuit capability is finally realized.

Classes IPC  ?

• H01L 29/40 - Electrodes
• H01L 23/31 - Encapsulations, p. ex. couches d’encapsulation, revêtements caractérisées par leur disposition
• H01L 29/20 - Corps semi-conducteurs caractérisés par les matériaux dont ils sont constitués comprenant, à part les matériaux de dopage ou autres impuretés, uniquement des composés AIIIBV
• H01L 29/66 - Types de dispositifs semi-conducteurs
• H01L 29/778 - Transistors à effet de champ avec un canal à gaz de porteurs de charge à deux dimensions, p.ex. transistors à effet de champ à haute mobilité électronique HEMT

Abrégé

The present disclosure provides a method and an apparatus for operating an in-memory computing architecture applied to a neural network and a device, the method includes: generating a mono-pulse input signal based on discrete time coding; inputting the mono-pulse input signal into a memory array of the in-memory computing architecture to generate a bit line current signal corresponding to the memory array; and controlling a neuron circuit of the in-memory computing architecture to output a mono-pulse output signal based on discrete time coding according to the bit line current signal, wherein the mono-pulse output signal is configured as a mono-pulse input signal of a memory array of the next layer of neural network in the next in-memory computing cycle.

Classes IPC  ?

• G11C 7/10 - Dispositions d'interface d'entrée/sortie [E/S, I/O] de données, p. ex. circuits de commande E/S de données, mémoires tampon de données E/S
• G06F 17/16 - Calcul de matrice ou de vecteur

Abrégé

Provided here is use of Lacticaseibacillus paracasei or postbiotics thereof for the manufacture of a pharmaceutical or a food composition for generating a cholic acid conjugated to tryptophan. The Lacticaseibacillus paracasei or the postbiotics thereof can be used for preventing and/or treating a metabolic disease, or for promoting GLP-1 and/or insulin production, or for maintaining healthy blood glucose level, maintaining healthy lipid level and/or controlling body fat.

Classes IPC  ?

• A61K 35/747 - Lactobacilles, p. ex. L. acidophilus ou L. brevis
• A61P 1/10 - Laxatifs
• A61P 3/04 - AnorexigènesMédicaments de l'obésité
• A61P 3/06 - Antihyperlipémiants
• A61P 3/10 - Médicaments pour le traitement des troubles du métabolisme de l'homéostase du glucose de l'hyperglycémie, p. ex. antidiabétiques
• A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
• C12Q 1/02 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des micro-organismes viables
• C12P 7/42 - Acides hydroxycarboxyliques
• C12P 13/22 - TryptophaneTyrosinePhénylalanineDihydroxy-3, 4 phénylalanine
• A23L 33/135 - Bactéries ou leurs dérivés, p. ex. probiotiques

Abrégé

Provided is the use of a conjugated cholic acid, tryptophan-conjugated bile acids (TrpCA) or a TrpCA-producing strain for preventing and/or treating a metabolic disease. The present disclosure relates to the use of tryptophan-conjugated cholic acid or its producing bacteria strain in the preparation of a composition for preventing and/or treating a metabolic disease, or for promoting GLP-1 and/or insulin production. The inventors have discovered for the first time that the tryptophan-conjugated cholic acid can significantly promote the secretion of GLP-1 in both in vivo animal model and in vitro cell model, thereby reducing weight, lowering blood glucose and relieving symptoms of non-alcoholic fatty liver disease. Moreover, colonization of the selected probiotics can also have the same metabolic improvement effects.

Classes IPC  ?

• A23L 33/135 - Bactéries ou leurs dérivés, p. ex. probiotiques
• A23L 33/17 - Acides aminés, peptides ou protéines

Abrégé

A diazo compound and a preparation method and a use thereof. The diazo compound has the structure as shown in formula A diazo compound and a preparation method and a use thereof. The diazo compound has the structure as shown in formula A diazo compound and a preparation method and a use thereof. The diazo compound has the structure as shown in formula wherein R1 represents H, alkyl, halogen, alkoxy or alkylamino; and R2 represents an aromatic group. On the basis of the aforementioned diazo compound as a derivatization reagent, the derivatization treatment of a small molecule carboxylic acid can significantly enhance the mass spectrometry response thereof and improve the detection sensitivity, thereby improving the detection accuracy. Moreover, it is not required to configure special chromatographic columns or special mobile phases for the derivatized small molecule carboxylic acid, and the best separation effect in a shorter time can be achieved on the basis of a lower cost, which is more conducive to high-throughput sample detection and has better detection accuracy.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
• C07C 249/02 - Préparation de composés contenant des atomes d'azote, liés par des liaisons doubles à un squelette carboné de composés contenant des groupes imino
• C07C 251/24 - Composés contenant des atomes d'azote, liés par des liaisons doubles à un squelette carboné contenant des groupes imino ayant des atomes de carbone de groupes imino liés à des atomes de carbone de cycles aromatiques à six chaînons
• C07D 215/14 - Radicaux substitués par des atomes d'oxygène
• G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
• G01N 33/531 - Production de matériaux de tests immunochimiques

Abrégé

The use of piceatannol as an immune function enhancer in tumor immunotherapy, which use belongs to the technical field of biomedicine. Piceatannol can regulate the ratio and function of immune cells such as T cells, B cells, macrophages, neutrophils, monocytes and myeloid-derived suppressor cells, thereby improving an immune microenvironment in the body, remodeling a tumor immune microenvironment by means of inhibiting the migration of immunosuppressive cells to tumors, and inhibiting the growth and metastasis of melanoma, colorectal cancer and breast cancer. Piceatannol has application prospects in the treatment and prevention of various cancers. It is suggested that piceatannol can significantly improve the effects on anti-tumor immune responses and remodel the tumor immune microenvironment, thereby effectively inhibiting tumor proliferation, growth and metastasis, and can be used for the preparation of a drug for regulating immune cell functions or can be used as a lead compound for the development of a tumor immunotherapeutic drug.

Classes IPC  ?

• A61K 31/05 - Phénols
• A61P 35/00 - Agents anticancéreux

Abrégé

A nonlinear optical crystal structure is provided. The nonlinear optical crystal structure includes a plurality of two-dimensional material films, wherein the plurality of two-dimensional material films are stacked in a direction perpendicular to a two-dimensional plane thereof, and two-dimensional material films adjacent to each other are bonded by van der Waals forces, each of the plurality of two-dimensional material films is a crystal with a center-inversion-asymmetric crystal structure, and has a predetermined lattice orientation parallel to the two-dimensional plane in a direction parallel to the two-dimensional plane, there is a non-zero twist angle between the two-dimensional material films adjacent to each other, and the twist angle is an included angle between predetermined lattice orientations of the two-dimensional material films adjacent to each other in the same two-dimensional plane, and a thickness of each of the plurality of two-dimensional material films is greater than 5 nm.

Classes IPC  ?

• G02F 1/355 - Optique non linéaire caractérisée par les matériaux utilisés
• G02F 1/35 - Optique non linéaire
• G02F 1/37 - Optique non linéaire pour la génération de l'harmonique deux

Abrégé

A spatial information trajectory visualization method supporting expression of uncertainty level, belonging to the field of visualization. The method comprises: on the basis of actual spatial information, extracting a spatial uncertainty level from spatial data to be expressed; according to the extracted spatial uncertainty level, performing abstract map node layout, organizing locations in the trajectory into a nested circular structure according to a spatial uncertainty level organization, placing locations having determined positions inside a circle, placing locations having uncertain positions on a circle boundary, and drawing a trajectory path using a quadratic Bézier curve. The present method targets spatial information trajectory data having an uncertainty level, and, by means of constraint conditions such as geographic space and linking relationships, obtains an optimized layout for abstract map nodes, thereby avoiding misunderstandings caused by uncertain places drawn on a geographic map, and retaining, as much as possible, known information and association relationships; trajectory characteristics can be objectively and effectively shown, and a reliable foundation is laid for the development of spatial information visualization.

Classes IPC  ?

• G06F 16/26 - Exploration de données visuellesNavigation dans des données structurées

Abrégé

An intelligent deformable microneedle includes a supporting seat; a counter electrode provided above the supporting seat; an elastic object with a compressed state and a natural state, where a working electrode is provided on an outer surface of the elastic object, and a specific enzyme that can react with an analyte to be detected is provided on the working electrode; a soluble needle-shaped body fixed on the supporting seat, where the soluble needle-shaped body completely wraps the counter electrode and the elastic object from the outside, and the soluble needle-shaped body has an inner cavity structure that enables the elastic object to be in the compressed state. The microneedle is internally provided with the elastic object, after penetrating into skin, the soluble needle-shaped body is dissolved, the elastic object inside is exposed, length becomes longer, and the working electrode of an electrochemical sensor is attached to the elastic object.

Classes IPC  ?

• A61B 5/1486 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang en utilisant des procédés chimiques ou électrochimiques, p. ex. par des moyens polarographiques en utilisant des électrodes enzymatiques, p. ex. avec oxydase immobilisée
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
• B33Y 80/00 - Produits obtenus par fabrication additive

Abrégé

The present application provides methods for producing circular RNAs (circRNAs) from a DNA construct encoding a linear RNA precursor, wherein the linear RNA precursor comprises from the 5′-end to the 3′ end: a 3′ catalytic Group I intron fragment, a 3′ exon sequence, an effector RNA sequence, a 5′ exon sequence, and a 5′ catalytic Group I intron fragment, wherein the method comprises an in vitro single-pot reaction. In some embodiments, the single-pot reaction does not comprise supplementing the reagent composition with GTP, a divalent metal ion such as Mg2+, or DNase I prior to circularization of a linear RNA precursor.

Classes IPC  ?

• C12P 19/34 - Polynucléotides, p. ex. acides nucléiques, oligoribonucléotides

Abrégé

Compositions useful for delaying reproductive aging in an individual comprise L-ergothioneine and ginsenoside Rb1. Methods of delaying reproductive aging, such as methods of treating age-related ovarian granulosa cell injury.

Classes IPC  ?

• A61K 31/4172 - Acides imidazole-alkanecarboxyliques, p. ex. histidine
• A61K 31/704 - Composés ayant des radicaux saccharide liés à des composés non-saccharide par des liaisons glycosidiques liés à un composé carbocyclique, p. ex. phloridzine liés à un système carbocyclique condensé, p. ex. sennosides, thiocolchicosides, escine, daunorubicine, digitoxine
• A61P 15/08 - Médicaments pour le traitement des troubles génitaux ou sexuelsContraceptifs pour les troubles gonadiques ou pour augmenter la fertilité, p. ex. inducteurs d'ovulation ou de spermatogénèse

Abrégé

The present disclosure provides a semiconductor structure and a preparation method therefor, a semiconductor device, and an electronic device. The preparation method comprises: providing a substrate; sequentially forming a first material layer and a second material layer made of materials having different lattice constants on the substrate; etching the first material layer and the second material layer, to form a fin structure comprising a first part formed of the first material layer undergone etching and a second part formed of the second material layer undergone etching; forming an underlying transistor on the basis of the second part; and on the basis of the first part after flipping, forming a top layer transistor.

Classes IPC  ?

• H01L 21/8238 - Transistors à effet de champ complémentaires, p.ex. CMOS
• H01L 27/092 - Transistors à effet de champ métal-isolant-semi-conducteur complémentaires

Abrégé

The present disclosure provides a semiconductor structure and a preparation method therefor, a semiconductor device, and an electronic device. The preparation method comprises: providing a substrate; forming an active structure on the substrate, the active structure having a first portion and a second portion; forming a shallow trench isolation layer on the substrate to cover the second portion; forming an etch stop layer on the shallow trench isolation layer; forming a bottom-layer transistor on the basis of the first portion; performing flip-chip processing and etching the substrate and the shallow trench isolation layer to expose the etch stop layer and the second portion; and forming a top-layer transistor on the basis of the second portion. A first gate structure of the bottom-layer transistor and a second gate structure of the top-layer transistor are located on two opposite sides of the etch stop layer.

Classes IPC  ?

• H01L 21/8238 - Transistors à effet de champ complémentaires, p.ex. CMOS
• H01L 27/092 - Transistors à effet de champ métal-isolant-semi-conducteur complémentaires

Abrégé

Provided in the present disclosure are a semiconductor structure, a manufacturing method therefor, a semiconductor device and an electronic device. The method comprises: providing a substrate; forming an active structure on the substrate, the active structure comprising a first active structure and a second active structure; filling the active structure with an oxide to form shallow trench isolation; removing a first part of the shallow trench isolation so as to expose the first active structure; on the basis of the first active structure, forming a first transistor, a first gate structure of the first transistor wrapping the first active structure; depositing a first insulating layer on the top of the first transistor, and bonding the first insulating layer to a carrier wafer; flipping over the first transistor; removing the substrate and a second part of the shallow trench isolation so as to expose the second active structure; and, on the basis of the second active structure, forming a second transistor, a second gate structure of the second transistor wrapping the second active structure.

Classes IPC  ?

• H01L 21/8238 - Transistors à effet de champ complémentaires, p.ex. CMOS
• H01L 27/092 - Transistors à effet de champ métal-isolant-semi-conducteur complémentaires

Abrégé

The present invention provides a preparation method for a semiconductor structure, a semiconductor structure and device, and a device. The method comprises: forming active structures on a substrate, the active structures comprising first active structures and second active structures, and the first active structures being distant from the substrate with respect to the second active structures; forming on the substrate isolation structures surrounding the second active structures, so as to expose the first active structures; on the basis of the first active structures, forming a first transistor, the first transistor at least comprising a first gate structure; performing a flip operation on the first transistor to expose the second active structures; on the basis of the second active structures, forming a second transistor, the second transistor at least comprising a second gate structure; and forming an interconnection structure in a first area, the interconnection structure being used for connecting the first gate structure and the second gate structure, and the first area being located between the active structures and the boundary of one side of a gate area.

Classes IPC  ?

• H01L 21/8238 - Transistors à effet de champ complémentaires, p.ex. CMOS
• H01L 27/092 - Transistors à effet de champ métal-isolant-semi-conducteur complémentaires

Abrégé

Provided in the present disclosure are a semiconductor structure and a preparation method therefor, and a semiconductor device and an electronic device. The preparation method comprises: forming an active structure on a semiconductor substrate, wherein the active structure comprises a first active structure and a second active structure; forming a first transistor on the basis of the first active structure, wherein the first transistor comprises a first source-drain structure, a first source-drain metal and a first interlayer dielectric layer; inverting the first transistor, and removing the semiconductor substrate; and forming a second transistor on the basis of the second active structure, wherein the second transistor comprises a second source-drain structure, a second source-drain metal and a second interlayer dielectric layer, the first source-drain metal and the second source-drain metal being connected by means of an interconnection through-hole structure, and the interconnection through-hole structure penetrating the first interlayer dielectric layer and the second interlayer dielectric layer.

Classes IPC  ?

• H01L 21/8234 - Technologie MIS
• H01L 21/8238 - Transistors à effet de champ complémentaires, p.ex. CMOS
• H01L 27/088 - Dispositifs consistant en une pluralité de composants semi-conducteurs ou d'autres composants à l'état solide formés dans ou sur un substrat commun comprenant des éléments de circuit passif intégrés avec au moins une barrière de potentiel ou une barrière de surface le substrat étant un corps semi-conducteur comprenant uniquement des composants semi-conducteurs d'un seul type comprenant uniquement des composants à effet de champ les composants étant des transistors à effet de champ à porte isolée

Abrégé

The present disclosure provides the utilization of an RPN11 marker in detecting myeloma and assessing disease risk, prognostic analysis, and therapeutic drug development. This includes a detection reagent and a kit for detecting smoldering multiple myeloma (SMM) and multiple myeloma (MM) and assessing disease risk. Additionally, it involves molecular typing of MM patients' cassette, prognostic analysis of the MM patients, and predicting the response of the MM patients to a bortezomib treatment. It entails the use of an RPN11 inhibitor in preparation of a pharmaceutical composition for treating MM characterized by drug-resistant t(4;14) translocation and a high RPN11 expression level. Notably, the combined use of the RPN11 with histone methyltransferase (HMT) enhances detection sensitivity and accuracy, preventing a mismatch between the patients' genotype and the prediction of disease development, and can effectively predict the overall survival and prognosis of MM patients with t(4;14) translocation.

Classes IPC  ?

• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
• A61K 31/4709 - Quinoléines non condensées contenant d'autres hétérocycles
• A61P 35/00 - Agents anticancéreux
• G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

A photosensitizer chimera targeting PD-L1 protein, and a preparation method therefor and a use thereof. The photosensitizer chimera is of an X-R-G structure, wherein X is a photosensitizer unit, R is a linker, G is a polypeptide unit targeting PD-L1 protein, the photosensitizer is a porphyrin photosensitizer, and the excitation light wavelength of the photosensitizer is longer than 550 nm; the molar absorption coefficient at the maximum absorption wavelength longer than the wavelength of 550 nm is greater than 1000 M -1cm-1; the quantum yield of a triplet state exceeds 0.01; the linker is selected from the following structural formulas, wherein the amino side of the linker is connected to the photosensitizer unit, the carboxyl side of the linker is connected to the polypeptide unit, and n is an integer of 0-50; the binding constant of the polypeptide and h-PD-L1 is less than 20 µm. Combination therapy of immune checkpoint blockade and cytotoxicity induced by the photosensitive chimera based on photodegradation of PD-L1 protein in PD-1/PD-L1 can cause stronger immune response than monotherapy, and thus the photosensitive chimera has great potential in enhancing antitumor therapy.

Classes IPC  ?

• C07K 19/00 - Peptides hybrides
• A61K 41/00 - Préparations médicinales obtenues par traitement de substances par énergie ondulatoire ou par rayonnement corpusculaire
• A61K 47/60 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique macromoléculaire, p. ex. une molécule oligomérique, polymérique ou dendrimérique obtenu par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyurées ou polyuréthanes le composé organique macromoléculaire étant un oligomère, un polymère ou un dendrimère de polyoxyalkylène, p. ex. PEG, PPG, PEO ou polyglycérol
• A61P 35/00 - Agents anticancéreux

Abrégé

The present invention discloses a method for enhancing the activity of a photosensitizer by a magnetic field, in which the photosensitizer is placed in the magnetic field under light conditions, thus improving the cytotoxicity of the photosensitizer to tumor cells and increasing the activity of the photosensitizer, thereby further enhancing the apoptosis of cancer cells or an inhibitory effect on tumor tissue by using photodynamic treatment methods, which helps to improve an effect of photodynamic therapy.

Classes IPC  ?

• A61N 5/06 - Thérapie par radiations utilisant un rayonnement lumineux

Abrégé

The present disclosure provides a carborane-phospholipid conjugate, in which carboranyl is introduced at the end of the arm of a phospholipid. The present disclosure also provides a liposome composition including the carborane-phospholipid conjugate, and a use of the composition in delivering at least one therapeutic agent and/or at least one diagnostic agent.

Classes IPC  ?

• C07F 9/09 - Esters des acides phosphoriques
• A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
• A61K 47/24 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant des atomes autres que des atomes de carbone, d'hydrogène, d'oxygène, d'halogènes, d'azote ou de soufre, p. ex. cyclométhicone ou phospholipides

Abrégé

Disclosed is a method for implementing a content addressable memory based on an ambipolar FET, wherein a linear non-separable comparison operation required for a CAM cell is realized based on a single ambipolar FET with a threshold voltage through interposing a memory layer between a gate dielectric layer and a control gate of the ambipolar FET in source/drain symmetry to modulate the threshold voltage for information storage and through utilizing its non-monotonic transfer characteristics for input search.

Classes IPC  ?

• G11C 15/04 - Mémoires numériques dans lesquelles l'information, comportant une ou plusieurs parties caractéristiques, est écrite dans la mémoire et dans lesquelles l'information est lue au moyen de la recherche de l'une ou plusieurs de ces parties caractéristiques, c.-à-d. mémoires associatives ou mémoires adressables par leur contenu utilisant des éléments semi-conducteurs

Abrégé

The present application provides a method and kit for detecting N6-methyladenine in a nucleic acid molecule.

Classes IPC  ?

• C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]

Abrégé

The present disclosure provides an immunoassay device, and a preparation method and use thereof, and belongs to the technical field of biological detection. In the present disclosure, the immunoassay device includes a test strip and a thin film pump, where a driving component in the thin film pump is connected to a printed circuit board (PCB) or a chip outside the thin film pump through a wire, to control starting or turning off of the thin film pump; and a liquid outlet of the thin film pump is closely attached to a top of a conjugate pad of the test strip, or a top of a sample pad of the test strip, or a top of a middle part between the conjugate pad and the sample pad.

Classes IPC  ?

• G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
• G01N 21/84 - Systèmes spécialement adaptés à des applications particulières

Abrégé

The present disclosure provides a TSV interposer and a manufacturing method therefor, and a three-dimensional chip. The TSV interposer comprises: a substrate provided therein with a cavity and a first structure layer covering part of the inner wall of the cavity, wherein the material type of the first structure layer is different from that of the substrate; a through via structure running through the substrate and located on one side of the cavity; and liquid metal located in the cavity, wherein the liquid metal and the first structure layer comprise the same material element. According to the present disclosure, the problem in the prior art of poor heat dissipation capability of TSV interposers is solved.

Classes IPC  ?

• H01L 23/498 - Connexions électriques sur des substrats isolants

Abrégé

The present invention relates to a pharmacokinetics modified FAP-α specific radiopharmaceutical and a use thereof, and specifically provides a novel pharmacokinetic linker modified OncoFAP molecule. The molecule can be coupled to bifunctional chelators (BFCs), including HYNIC, MAG2, MAG3, DTPA, DOTA, NOTA, (±)-H3RESCA, TETA, etc., for labeling nuclides such as 99mTc, 68Ga, 64Cu, 18F, 111In, 90Y, and 177Lu, and then, by using nuclear medicine imaging technology, imaging diagnosis and nuclide therapy are carried out on FAP-positive tumors or fibrotic diseases.

Classes IPC  ?

• C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
• A61K 31/4709 - Quinoléines non condensées contenant d'autres hétérocycles
• A61P 35/00 - Agents anticancéreux
• A61K 51/04 - Composés organiques

Abrégé

The present invention relates to the technical field of visualization and human-computer interaction, and in particular to a visual analysis system and method for astronomical spectrum type inspection. The system comprises: a data preprocessing module used for preprocessing reference spectra and spectra to be inspected, to complete spectrum normalization, spectrum feature detection and spectrum characterization; a selection module used for helping a user to select a spectrum to be inspected and determine a possible redshift and important spectral lines under the redshift; an inspection module used for helping the user to determine the redshift and type of the spectrum to be inspected, the inspection module comprising an adjustment sub-module, a recommendation sub-module and a verification sub-module, which are respectively used for adjusting the redshift of the spectrum to be inspected, recommending a proper spectral line to the user and evaluating an inspection result; and a promotion module used for helping the user to obtain other spectra similar to the inspected spectrum by means of searching. The system and method provided by the present invention can significantly improve the classification efficiency while ensuring the spectrum classification accuracy of experts.

Classes IPC  ?

• G01N 21/25 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes
• G06V 10/764 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant la classification, p. ex. des objets vidéo
• G06V 10/58 - Extraction de caractéristiques d’images ou de vidéos relative aux données hyperspectrales

Abrégé

The present disclosure provides compounds that can inhibit the type III secretion system (TTSS) to decrease the pathogenesis of gram-negative bacteria. These compounds may have wide applications for treating bacteria diseases caused by gram-negative bacteria in a host species, including but not limited to, plants and animals. The present invention further relates to compositions that inhibit pathogenesis of gram-negative bacteria without killing the bacteria. Methods relating to preventing and/or treating infection of a host species by bacterial pathogens are also provided herein.

Classes IPC  ?

• C07C 233/09 - Amides d'acides carboxyliques ayant des atomes de carbone de groupes carboxamide liés à des atomes d'hydrogène ou à des atomes de carbone acycliques ayant les atomes d'azote des groupes carboxamide liés à des atomes d'hydrogène ou à des atomes de carbone de radicaux hydrocarbonés non substitués avec des atomes de carbone de groupes carboxamide liés à des atomes de carbone d'un squelette carboné acyclique non saturé
• A01N 33/04 - AminesComposés d'ammonium quaternaire l'atome d'azote étant lié directement à des atomes de carbone aliphatiques ou cycloaliphatiques
• A01N 37/18 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques comportant un atome de carbone possédant trois liaisons à des hétéro-atomes, avec au plus deux liaisons à un halogène, p. ex. acides carboxyliques contenant le groupe —CO—N, p. ex. amides ou imides d'acide carboxyliqueLeurs thio-analogues
• A01N 37/20 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques comportant un atome de carbone possédant trois liaisons à des hétéro-atomes, avec au plus deux liaisons à un halogène, p. ex. acides carboxyliques contenant le groupe —CO—N, p. ex. amides ou imides d'acide carboxyliqueLeurs thio-analogues contenant le groupe , dans lequel Cn représente un squelette carboné ne comportant pas de cycleLeurs thio-analogues
• A01N 37/28 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques comportant un atome de carbone possédant trois liaisons à des hétéro-atomes, avec au plus deux liaisons à un halogène, p. ex. acides carboxyliques contenant le groupe —CO—N, p. ex. amides ou imides d'acide carboxyliqueLeurs thio-analogues contenant le groupe Leurs thio-analogues
• A01N 43/08 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un ou plusieurs atomes d'oxygène ou de soufre comme uniques hétéro-atomes du cycle avec un hétéro-atome des cycles à cinq chaînons avec l'oxygène comme hétéro-atome du cycle
• A01P 1/00 - DésinfectantsComposés antimicrobiens ou leurs mélanges
• A61K 31/131 - Amines, p. ex. amantadine acycliques
• A61K 31/16 - Amides, p. ex. acides hydroxamiques
• A61K 31/164 - Amides, p. ex. acides hydroxamiques d'un acide carboxylique avec un aminoalcool, p. ex. céramides
• A61K 31/165 - Amides, p. ex. acides hydroxamiques ayant des cycles aromatiques, p. ex. colchicine, aténolol, progabide
• A61K 31/17 - Amides, p. ex. acides hydroxamiques ayant le groupe N-C(O)-N ou N-C(S)-N, p. ex. urée, thiourée, carmustine
• A61K 31/365 - Lactones
• C07C 211/21 - Monoamines
• C07C 231/02 - Préparation d'amides d'acides carboxyliques à partir d'acides carboxyliques ou à partir de leurs esters, anhydrides ou halogénures par réaction avec de l'ammoniac ou des amines
• C07C 233/05 - Amides d'acides carboxyliques ayant des atomes de carbone de groupes carboxamide liés à des atomes d'hydrogène ou à des atomes de carbone acycliques ayant les atomes d'azote des groupes carboxamide liés à des atomes d'hydrogène ou à des atomes de carbone de radicaux hydrocarbonés non substitués avec des atomes de carbone de groupes carboxamide liés à des atomes de carbone d'un squelette carboné saturé acyclique ayant les atomes d'azote des groupes carboxamide liés à des atomes d'hydrogène ou à des atomes de carbone acycliques
• C07C 233/11 - Amides d'acides carboxyliques ayant des atomes de carbone de groupes carboxamide liés à des atomes d'hydrogène ou à des atomes de carbone acycliques ayant les atomes d'azote des groupes carboxamide liés à des atomes d'hydrogène ou à des atomes de carbone de radicaux hydrocarbonés non substitués avec des atomes de carbone de groupes carboxamide liés à des atomes de carbone d'un squelette carboné non saturé contenant des cycles aromatiques à six chaînons
• C07C 233/18 - Amides d'acides carboxyliques ayant des atomes de carbone de groupes carboxamide liés à des atomes d'hydrogène ou à des atomes de carbone acycliques ayant l'atome d'azote d'au moins un des groupes carboxamide lié à un atome de carbone d'un radical hydrocarboné substitué par des atomes d'oxygène liés par des liaisons simples avec le radical hydrocarboné substitué lié à l'atome d'azote du groupe carboxamide par un atome de carbone acyclique ayant l'atome de carbone du groupe carboxamide lié à un atome d'hydrogène ou à un atome de carbone d'un squelette carboné acyclique saturé
• C07C 233/20 - Amides d'acides carboxyliques ayant des atomes de carbone de groupes carboxamide liés à des atomes d'hydrogène ou à des atomes de carbone acycliques ayant l'atome d'azote d'au moins un des groupes carboxamide lié à un atome de carbone d'un radical hydrocarboné substitué par des atomes d'oxygène liés par des liaisons simples avec le radical hydrocarboné substitué lié à l'atome d'azote du groupe carboxamide par un atome de carbone acyclique ayant l'atome de carbone du groupe carboxamide lié à un atome de carbone d'un squelette carboné acyclique non saturé
• C07C 239/14 - Composés hydroxylaminés ou leurs éthers ou esters ayant des atomes d'azote de groupes hydroxylamino liés de plus à des atomes de carbone de radicaux hydrocarbonés substitués par des atomes d'oxygène liés par des liaisons doubles
• C07C 273/18 - Préparation d'urée ou de ses dérivés, c.-à-d. de composés contenant l'un des groupes les atomes d'azote ne faisant pas partie de groupes nitro ou nitroso d'urées substituées
• C07C 275/20 - Dérivés d'urée, c.-à-d. composés contenant l'un des groupes les atomes d'azote ne faisant pas partie de groupes nitro ou nitroso ayant des atomes d'azote de groupes urée liés à des atomes de carbone acycliques d'un squelette carboné non saturé
• C07D 307/33 - Atomes d'oxygène en position 2, l'atome d'oxygène étant sous la forme céto ou énol non substituée

Abrégé

Disclosed is a lateral flow immunoassay device for albumin detection, including one or more strips that are formed by sequentially connecting the following components: a) a sample pad for receiving a sample to be tested; b) a conjugate pad for temporarily storing a gold nanoparticle labeled antibody; c) a test region for immobilizing an antigen, a nitrocellulose membrane being arranged above the test region; and d) an absorbent pad for increasing capillarity; two ends of the nitrocellulose membrane overlap with the conjugate pad and the absorbent pad at an overlapping length of 1 mm to 5 mm, respectively; and further including: e) a backing card for supporting the above components, the backing card being a transparent glass, an upper surface of the transparent glass being provided with the test region for immobilizing the antigen to capture the gold nanoparticle labeled antibody, and the transparent glass being pretreated by silanization.

Classes IPC  ?

• G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

A nanoparticle drug based on a small interfering RNA (siRNA) targeting JFK and use thereof are provided. Nucleotide sequences of the sense strand and the antisense strand of the siRNA targeting JFK are set forth in SEQ ID NO: 1 and SEQ ID NO: 2, respectively. Liposomes can be used to encapsulate the complex of the siRNA and a protamine to produce a nanoparticle drug targeting JFK, which may be used to treat a disease related to abnormally-high expression of JFK. In this disclosure, breast cancer 4T1 cell-based tumor-bearing mice serve as the model for evaluating the anti-tumor activity of combined therapy involving the nanoparticle drug targeting JFK and radiotherapy. The results reveal that this combined therapy exhibits superior anti-tumor activity compared to the control group.

Classes IPC  ?

• A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique
• A61K 9/51 - Nanocapsules
• A61K 31/713 - Acides nucléiques ou oligonucléotides à structure en double-hélice
• A61K 38/02 - Peptides à nombre indéterminé d'amino-acidesLeurs dérivés
• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens

Abrégé

Provided in the present application are a kind of aza[3.2.1] bridged ring substituted fluorescent dye, and a preparation method therefor and the use thereof. In this kind of fluorescent dye, the aza [3.2.1] bridged ring is used as the substituent of the fluorescent dye, which significantly improves the brightness and light stability of the fluorescent dye, completely avoids a blue shift of light of the dye after long-term illumination, and can also effectively improve the water solubility of the fluorescent dye and maintains good cell membrane permeability thereof. Also provided in the present application are embodiments of functionalized derivatives of this kind of dye for single-molecule imaging, confocal imaging and super-resolution imaging in biological samples.

Classes IPC  ?

• C09B 19/00 - Colorants oxaziniques
• C09B 57/00 - Autres colorants synthétiques de structure connue
• C07D 451/00 - Composés hétérocycliques contenant des systèmes cycliques aza-8 bicyclo [3.2.1] octane, aza-9 bicyclo [3.3.1] nonane ou oxa-3 aza-9 tricyclo [3.3.1.02,4] nonane, p. ex. alcaloïdes du tropane ou du granatane, scopolamineLeurs acétals cycliques
• A61K 31/46 - Aza-8-bicyclo[3.2.1]octaneSes dérivés, p. ex. atropine, cocaïne
• G01N 33/533 - Production de composés immunochimiques marqués avec un marqueur fluorescent
• G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées

Abrégé

A radiation-activatable compound, a drug conjugate thereof and the use thereof, and the use of the compound as a drug conjugate linking group.

Classes IPC  ?

• C07D 405/12 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
• C07D 217/12 - Composés hétérocycliques contenant les systèmes cycliques de l'isoquinoléine ou de l'isoquinoléine hydrogénée avec des radicaux, substitués par des hétéro-atomes, liés aux atomes de carbone du cycle contenant l'azote
• C07D 213/02 - Composés hétérocycliques contenant des cycles à six chaînons, non condensés avec d'autres cycles, ne comportant qu'un atome d'azote comme unique hétéro-atome du cycle et avec au moins trois doubles liaisons entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques comportant trois liaisons doubles
• A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique
• A61K 49/00 - Préparations pour examen in vivo
• A61K 41/00 - Préparations médicinales obtenues par traitement de substances par énergie ondulatoire ou par rayonnement corpusculaire
• A61P 35/00 - Agents anticancéreux

Abrégé

The present disclosure provides a complementary storage circuit and a memory. The complementary storage circuit comprises storage units distributed in a matrix array, each storage unit comprises at least one group of P-channel field-effect transistors and N-channel field-effect transistors which are alternately connected, sources of the P-channel field-effect transistors are connected to drains of the N-channel field-effect transistors, and drains of the P-channel field-effect transistors are connected to sources of the N-channel field-effect transistors. According to the present disclosure, the density of a storage array can be improved, and the requirements for the driving capability of field-effect transistors are reduced.

Classes IPC  ?

• G11C 16/04 - Mémoires mortes programmables effaçables programmables électriquement utilisant des transistors à seuil variable, p. ex. FAMOS

Abrégé

Disclosed is a method for monolithic integration preparation of a full-color nitride semiconductor micro light-emitting diode (micro-LED) array. The method includes preparing a composite conductive substrate; overlaying an insulating template onto the composite conductive substrate to prepare a template substrate; overlaying monocrystalline graphene onto the template substrate in a completely aligned manner to obtain a customized template graphene substrate including graphene array units, wherein one blue-region graphene array element, one green-region graphene array element, and two red-region graphene array elements in each graphene array unit have surface properties different from each other; then performing an in-situ process to epitaxially grow a vertical-structure all-nitride material, to obtain a full-color micro-LED array epitaxial wafer by one-step in-situ process; finally, performing packaging and preparing a transparent electrode, to obtain a vertical-structure full-color nitride micro-LED array with top light emission.

Classes IPC  ?

• H01L 33/00 - DISPOSITIFS À SEMI-CONDUCTEURS NON COUVERTS PAR LA CLASSE - Détails
• H01L 25/075 - Ensembles consistant en une pluralité de dispositifs à semi-conducteurs ou d'autres dispositifs à l'état solide les dispositifs étant tous d'un type prévu dans une seule des sous-classes , , , , ou , p. ex. ensembles de diodes redresseuses les dispositifs n'ayant pas de conteneurs séparés les dispositifs étant d'un type prévu dans le groupe

Abrégé

The present invention provides a method for co-expressing two or more proteins. Specifically, the present invention provides a method for co-expressing two or more proteins in a cell or a cell-free system by using a linker comprising one or more Mitochondrial Processing Peptidase (MPP) cleavable sequences. This invention also provides an MPP cleavable sequence, a fusion protein comprising the MPP cleavable sequence, a nucleic acid or a vector encoding the MPP cleavable sequence or the fusion protein, and a cell expressing the MPP cleavable sequence or the fusion protein.

Classes IPC  ?

• C07K 19/00 - Peptides hybrides
• C12P 21/00 - Préparation de peptides ou de protéines
• C12N 15/62 - Séquences d'ADN codant pour des protéines de fusion
• C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteursVecteurs Utilisation d'hôtes pour ceux-ciRégulation de l'expression
• C12N 5/10 - Cellules modifiées par l'introduction de matériel génétique étranger, p. ex. cellules transformées par des virus

Abrégé

The present disclosure provides a storage array, comprising storage units distributed in a matrix array, wherein each storage unit comprises two memories, and one P-channel field effect transistor and two N-channel field effect transistors which are alternately connected; the source electrode of the P-channel field effect transistor is connected to the drain electrode of each N-channel field effect transistor; the drain electrode of the P-channel field effect transistor is connected to the source electrode of the N-channel field effect transistor; the two memories are respectively connected to the source electrode of the P-channel field effect transistor and the source electrode of the N-channel field effect transistor. Use of the present invention can improve the density of the storage array and reduce the requirements for the driving capability of field effect transistors.

Classes IPC  ?

• G11C 11/4074 - Circuits d'alimentation ou de génération de tension, p. ex. générateurs de tension de polarisation, générateurs de tension de substrat, alimentation de secours, circuits de commande d'alimentation

Abrégé

Provided in the present disclosure is a CMOS storage array, comprising storage units distributed in a matrix array, each storage unit comprising a memory, and a P-channel field effect transistor and an N-channel field effect transistor, which are connected in series, wherein a source electrode of the P-channel field effect transistor is connected to a drain electrode of the N-channel field effect transistor, a drain electrode of the P-channel field effect transistor is connected to a source electrode of the N-channel field effect transistor, and one end of the memory is connected to the drain electrode of the P-channel field effect transistor. By using the disclosure, the density of the storage array can be increased, and the requirement for a driving capability of a field effect transistor can be reduced.

Classes IPC  ?

• H10B 63/00 - Dispositifs de mémoire par changement de résistance, p. ex. dispositifs RAM résistifs [ReRAM]

Abrégé

Provided are methods and agents for promoting erythroid differentiation. Also provided are methods of increasing RNA polymerase II pausing mediated by a MED26 polypeptide. Also provided are methods of delivering a reagent to a cell.

Classes IPC  ?

• C12N 5/078 - Cellules du sang ou du système immunitaire
• C12N 5/0789 - Cellules souchesCellules progénitrices multipotentes
• A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
• C07K 14/435 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains

Abrégé

Embodiments of the present disclosure provide a repair patch generation method, a storage medium, and an electronic device. The method comprises: constructing a program code comprising a defect code into a first abstract syntax tree, and converting the first abstract syntax tree into a type flow graph by means of a type flow graph constructor, wherein the first abstract syntax tree carries type information; traversing the type flow graph to obtain a node sequence, an attribute sequence and a relation matrix, and inputting the node sequence, the attribute sequence and the relation matrix into a type flow graph encoder to obtain a feature vector; and inputting the feature vector and a grammar rule word list into a syntax-directed generator to obtain a second abstract syntax tree, and performing code instantiation on the second abstract syntax tree to generate a repair patch, wherein the second abstract syntax tree carries the type information.

Classes IPC  ?

• G06F 8/41 - Compilation

Abrégé

Provided are methods and systems for inhibiting nonsense-mediated mRNA decay in a gene-specific manner, for example in the treatment of diseases or disorders related to premature termination codons (PTCs).

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
• A61K 31/712 - Acides nucléiques ou oligonucléotides ayant des sucres modifiés, c.-à-d. autres que le ribose ou le 2'-désoxyribose

Abrégé

The present invention belongs to the field of nuclear medicine and relates to a Granzyme B-targeting complex, a radiopharmaceutical, a preparation method therefor and a use thereof. A structure of the Granzyme B-targeting complex is shown in formula (I), where R is any one of a bifunctional chelating group or a derivative thereof for radionuclide labeling. The Granzyme B-targeting complex provided by the present invention can be prepared into the Granzyme B-targeting radiopharmaceutical through radionuclide labeling. The Granzyme B-targeting radiopharmaceutical provided is simple to prepare and has better pharmacokinetic characteristics and in vivo metabolic stability than other Granzyme B-targeting drugs. The expression level of Granzyme B in vivo can be monitored noninvasively by nuclear medicine imaging. The present invention belongs to the field of nuclear medicine and relates to a Granzyme B-targeting complex, a radiopharmaceutical, a preparation method therefor and a use thereof. A structure of the Granzyme B-targeting complex is shown in formula (I), where R is any one of a bifunctional chelating group or a derivative thereof for radionuclide labeling. The Granzyme B-targeting complex provided by the present invention can be prepared into the Granzyme B-targeting radiopharmaceutical through radionuclide labeling. The Granzyme B-targeting radiopharmaceutical provided is simple to prepare and has better pharmacokinetic characteristics and in vivo metabolic stability than other Granzyme B-targeting drugs. The expression level of Granzyme B in vivo can be monitored noninvasively by nuclear medicine imaging.

Classes IPC  ?

• A61K 51/04 - Composés organiques
• A61P 35/00 - Agents anticancéreux

Abrégé

A bacterial capsular oligosaccharide derivative, a preparation method therefor, a pharmaceutical composition and a use thereof. The derivative is as shown in formula (I), and the substituent is described in detail in the description. The derivative has anti-inflammatory activity and can be used for treating sepsis. A bacterial capsular oligosaccharide derivative, a preparation method therefor, a pharmaceutical composition and a use thereof. The derivative is as shown in formula (I), and the substituent is described in detail in the description. The derivative has anti-inflammatory activity and can be used for treating sepsis.

Classes IPC  ?

• A61K 31/715 - Polysaccharides, c.-à-d. ayant plus de cinq radicaux saccharide liés les uns aux autres par des liaisons glycosidiquesLeurs dérivés, p. ex. éthers, esters
• A61K 31/7028 - Composés ayant des radicaux saccharide liés à des composés non-saccharide par des liaisons glycosidiques
• A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
• C07H 1/00 - Procédés de préparation des dérivés du sucre
• C07H 15/04 - Radicaux acycliques non substitués par des structures cycliques liés à un atome d'oxygène d'un radical saccharide
• C07H 15/18 - Radicaux acycliques substitués par des carbocycles

Abrégé

The present application relates to the technical field of two-dimensional materials, and relates to a transition metal chalcogenide wafer and a preparation method and apparatus therefor. The preparation method comprises: S1, assembling growth modules; and S2, vertically stacking the assembled growth modules to obtain a combined growth module; and placing the combined growth module in a container, heating to a preset temperature in an inert gas protection atmosphere, and carrying out chemical vapor deposition to obtain a wafer. The method uses a "plane-to-plane" local element supply technology, uses a highly reactive precursor, and effectively solves the uneven supply problem of "point-to-plane" diffusion growth sources in a traditional mode; using the precursor element supply method of the present application can greatly expand the size of prepared wafers, and expand the size of a single transition metal chalcogenide wafer to 12 inches or above, reaching a standard compatible with a contemporary semiconductor process; additionally, the batch production of a plurality of wafers can be realized by successively stacking growth modules.

Classes IPC  ?

• C30B 25/02 - Croissance d'une couche épitaxiale
• C30B 25/12 - Porte-substrat ou supports
• C30B 29/48 - Composés AII BVI
• C30B 29/46 - Composés contenant du soufre, du sélénium ou du tellure
• H01L 21/02 - Fabrication ou traitement des dispositifs à semi-conducteurs ou de leurs parties constitutives

Abrégé

Provided are a 7-hydroxy-butylphthalide nano-emulsion formulation, a preparation method therefor and a use thereof. Specifically, a 7-hydroxy-butylphthalide nano-emulsion formulation containing a phospholipid PEG derivative is developed, and a molecular action mechanism of 7-hydroxy-butylphthalide, a phospholipid and a phospholipid PEG derivative in the formulation is disclosed by means of multi-scale calculation simulation; the specification of the formulation is determined by means of prescription and process optimization; and the effectiveness of the formulation in treating cerebral apoplexy is verified by means of animal in-vivo pharmacodynamics evaluation, providing a reliable dosage form for meeting clinical medication. The present invention solves the problems of poor solubility of 7-hydroxy-butylphthalide and difficulty in drug preparation. Upon quality inspection, the encapsulation efficiency, the particle size, the Zeta potential and the like of the 7-hydroxy-butylphthalide nano-emulsion formulation meet the quality requirements of nano-drug formulations, the 7-hydroxy-butylphthalide nano-emulsion formulation is applied to the treatment of cerebral apoplexy of rats, and the treatment effect shows that the 7-hydroxy-butylphthalide nano-emulsion formulation has the potential of clinically treating tumors and great application value.

Classes IPC  ?

• A61K 9/107 - Émulsions
• A61K 31/365 - Lactones
• A61K 47/24 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant des atomes autres que des atomes de carbone, d'hydrogène, d'oxygène, d'halogènes, d'azote ou de soufre, p. ex. cyclométhicone ou phospholipides
• A61P 9/10 - Médicaments pour le traitement des troubles du système cardiovasculaire des maladies ischémiques ou athéroscléreuses, p. ex. médicaments antiangineux, vasodilatateurs coronariens, médicaments pour le traitement de l'infarctus du myocarde, de la rétinopathie, de l'insuffisance cérébro-vasculaire, de l'artériosclérose rénale

Abrégé

The present application relates to the technical field of magnetoencephalography detection. Provided are an atomic magnetometer magnetoencephalography system based on wireless transmission, and a magnetoencephalography detection method. The system comprises a worn structural member (100), an atomic magnetometer (200), a collection upper computer (300) and a manipulation module (400), wherein the atomic magnetometer (200) can form a magnetic field detection array; the collection upper computer (300) can be used for storing a magnetoencephalography signal collected by the atomic magnetometer (200); and the manipulation module (400) is electrically connected to the atomic magnetometer (200) by means of a flexible printed circuit (700), and the manipulation module (400) is connected to the collection upper computer (300) by means of a wireless communication. In the present application, a manipulation module can be connected to a collection upper computer without the need for a wired circuit, such that a wearer is not bound by the circuit during a test period, thereby solving the problem of the activity of a testee being limited. Moreover, there is no need to use a wired circuit between the manipulation module and the collection upper computer, and therefor there is no need to take the specification and cost of the wired circuit into consideration.

Classes IPC  ?

• A61B 5/245 - Détection de champs biomagnétiques, p. ex. de champs magnétiques produits par des courants bioélectriques spécialement adaptée aux signaux magnétoencéphalographiques [MEG]

Abrégé

A method for implementing a universal content addressable memory on the basis of N-type and P-type ferroelectric field effect transistors, which relates to the technical fields of novel storage and computation. According to the method, the complementary characteristics of an N-type FeFET and a P-type FeFET are utilized, so that it is possible to simultaneously achieve the functions of a TCAM, MACM and ACAM without extra hardware overhead. Moreover, a simpler search operation is provided, so that the storage density and search energy efficiency of a CAM are improved. When quantized into an MCAM that stores multi-level entry states, the CAM also has the ability to compress entry states, allowing the storage density of the CAM to be further improved, which is of great significance for CAM-based table lookup search operations.

Classes IPC  ?

• G11C 11/22 - Mémoires numériques caractérisées par l'utilisation d'éléments d'emmagasinage électriques ou magnétiques particuliersÉléments d'emmagasinage correspondants utilisant des éléments électriques utilisant des éléments ferro-électriques

Abrégé

xyz1-x-y-z22, wherein Li layers and transition metal layers are alternately arranged, 0.1

Classes IPC  ?

• H01M 4/505 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs d'oxydes ou d'hydroxydes inorganiques de manganèse d'oxydes ou d'hydroxydes mixtes contenant du manganèse pour insérer ou intercaler des métaux légers, p. ex. LiMn2O4 ou LiMn2OxFy

Abrégé

The disclosure discloses a method for parsing method and device, and an electronic device. The method includes: receiving a target instruction and a parameter processor set, wherein the target instruction includes a target instruction parameter vector, a composition element of the target instruction parameter vector is a target instruction parameter, the parameter processor set includes at least one parameter processor, and the parameter processor consists of a preset to-be-matched command parameter vector and a first preset anonymous function; determining, from the parameter processors, a target parameter processor matching the target instruction parameter in the target instruction parameter vector, and processing the target instruction parameter by using the target parameter processor, to obtain a processing result; and determining, according to the processing result, a processing command corresponding to the target instruction, and executing the processing command.

Classes IPC  ?

• G06F 9/30 - Dispositions pour exécuter des instructions machines, p. ex. décodage d'instructions

Abrégé

The embodiments of the present application provide a compilation optimization option grouping method, a computer device, and a storage medium, and belong to the field of computers. The method comprises: acquiring function call relationship information of a compiler (S101); according to the function call relationship information, grouping all of the compilation optimization options in the compiler, and obtaining a plurality of target compilation optimization option groups (S102); and using the plurality of target compilation optimization option groups as a target search space of the compiler (S103).

Classes IPC  ?

• G06F 11/36 - Prévention d'erreurs par analyse, par débogage ou par test de logiciel

Abrégé

An optimization and enhancement method for medical health physical examination big data includes following steps: all closed edges and all feature corner points in an anteroposterior spinal X-ray image are obtained, an internal difference coefficient of each closed edge relative to each other closed edge is obtained based on a positional distribution difference coefficient of each feature corner point within each closed edge relative to each feature corner point within each other closed edge, and the vertebral body edge probability of each closed edge is obtained by combing a rectangularity degree of each closed edge; the vertebral body edge confidence probability is obtained based on the rectangularity degree and the number of the feature corner points within each closed edge to select a reference vertebral body edge; all spinal vertebral bodies are obtained by a feature matching algorithm and grayscale enhancement is performed on all spinal vertebral bodies.

Classes IPC  ?

• G06T 7/00 - Analyse d'image
• G06T 5/40 - Amélioration ou restauration d'image utilisant des techniques d'histogrammes

Abrégé

The present disclosure provides a three-dimensional semiconductor memory array architecture and a preparation method therefor. The three-dimensional semiconductor memory array architecture comprises storage units consisting of novel memories distributed in multiple layers in the vertical direction, and vertical structures arranged between adjacent storage units, wherein vertical transistors are arranged in the vertical structures. Each novel memory has one end connected to a channel of the corresponding vertical transistor, and the other end connected to a bit line (BL) in the horizontal direction; the channel of the vertical transistor is connected to a source line (SL) in the horizontal direction; and a gate of the vertical transistor is wrapped in the center of the vertical structure by a gate dielectric material layer and a channel material layer. The present disclosure can meet the requirements of material diversity, array reliability, and process compatibility for novel memories, and is suitable for the integration of large-scale novel memory arrays.

Classes IPC  ?

• H10B 63/00 - Dispositifs de mémoire par changement de résistance, p. ex. dispositifs RAM résistifs [ReRAM]
• H10B 63/10 - Dispositifs RAM à changement de phase [PCRAM, PRAM]
• H10B 61/00 - Dispositifs de mémoire magnétique, p. ex. dispositifs RAM magnéto-résistifs [MRAM]
• H10B 51/20 - Dispositifs de RAM ferro-électrique [FeRAM] comprenant des transistors ferro-électriques de mémoire caractérisés par les agencements tridimensionnels, p. ex. avec des cellules à des niveaux différents de hauteur
• H10B 53/20 - Dispositifs RAM ferro-électrique [FeRAM] comprenant des condensateurs ferro-électriques de mémoire caractérisés par les agencements tridimensionnels, p. ex. avec des cellules à des niveaux différents de hauteur

Abrégé

Provided are methods of forming circularized RNA (circRNA) using intact Group I introns provided in cis or fragments of Group I introns provided in trans. Also provided are methods of forming circRNA using intact Group II introns provided in cis or fragments of Group II introns provided in trans.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
• A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique

Abrégé

The present invention relates to the field of biomedicine, in particular regenerative medicine. In particular, the present invention relates to a method for producing cardiomyocytes from differentiated cells, such as fibroblasts, by means of reprogramming using a Tyk2 inhibitor and/or a TGFβ inhibitor, and optionally a cardiomyocyte-inducing transcription factor.

Classes IPC  ?

• C12N 5/077 - Cellules mésenchymateuses, p. ex. cellules osseuses, cellules de cartilage, cellules stromales médulaires, cellules adipeuses ou cellules musculaires
• C12N 15/86 - Vecteurs viraux

Abrégé

A ternary content addressable memory, which comprises: an oxide semiconductor array, a peripheral write word line drive circuit connected to the oxide semiconductor array, a TCAM input, a precharging and comparison circuit, and a logic circuit; the write word line drive circuit is used for driving a write word line of the oxide semiconductor array; the TCAM input is used for inputting data to be queried; the precharging and comparison circuit is used for precharging a read word line corresponding to the data to be queried, comparing the voltage of the read word line against a preset reference voltage, and outputting a comparison result; and the logic circuit is used for determining, according to the comparison result, a storage address corresponding to the data to be queried. The use of the ternary content addressable memory increases the energy efficiency and degree of parallelism of searches carried out by the ternary content addressable memory.

Classes IPC  ?

• G11C 15/04 - Mémoires numériques dans lesquelles l'information, comportant une ou plusieurs parties caractéristiques, est écrite dans la mémoire et dans lesquelles l'information est lue au moyen de la recherche de l'une ou plusieurs de ces parties caractéristiques, c.-à-d. mémoires associatives ou mémoires adressables par leur contenu utilisant des éléments semi-conducteurs

Abrégé

A compute-in-memory circuit based on charge redistribution includes a memory array, multiple-functional output units (MFUs), multiplexers (MUXs), and a word line (WL) driver. The memory array includes memory cell rows and memory cell columns. Every two adjacent memory cells form a memory cell pair in sequence, and every two adjacent memory cell columns form a memory cell column pair in sequence. A grounded register capacitor is connected to a source line (SL) of each memory cell row. Input ends of each MFU are connected to a first bit line (BL) and a second BL of each memory cell column pair, respectively. Each MUX includes voltage-input ends and an output end, and the output end of each MUX is connected to the SL of each memory cell row in a one-to-one correspondence. An output end of the WL driver is connected to a WL of each memory cell row.

Classes IPC  ?

• G11C 7/10 - Dispositions d'interface d'entrée/sortie [E/S, I/O] de données, p. ex. circuits de commande E/S de données, mémoires tampon de données E/S
• G11C 7/12 - Circuits de commande de lignes de bits, p. ex. circuits d'attaque, de puissance, de tirage vers le haut, d'abaissement, circuits de précharge, circuits d'égalisation, pour lignes de bits

Abrégé

Provided are methods for inducing exon skipping in a pre-mRNA in a host cell comprising introducing a deaminase-recruiting RNA (dRNA) or a construct comprising a nucleic acid encoding the dRNA into the host cell, wherein the dRNA is a circular RNA (circRNA) or forms a circRNA within the host cell.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
• A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique

Abrégé

The present disclosure relates to the technical field of electrochemistry, and in particular, to a threadlike sensor, a wearable device and a method for fabricating the threadlike sensor. The threadlike sensor includes a thread core, an inner insulating layer, an outside electrode layer and an outer insulating layer. The inner insulating layer covers the thread core with two ends of the thread core being exposed by the inner insulating layer. The outside electrode layer is disposed outside the inner insulating layer. The outer insulating layer covers the outside electrode layer with two ends of the outside electrode layer being exposed by the outer insulating layer. One end of the threadlike sensor is a detection end configured for placement in a human body. The other end of the threadlike sensor is an interface end configured for external connection. The thread core and the outside electrode layer are configured for sensitivity testing.

Classes IPC  ?

• G01N 27/28 - Composants de cellules électrolytiques
• B29C 63/08 - Garnissage ou gainage, c.-à-d. application de couches ou de gainages préformés en matière plastiqueAppareils à cet effet avec des matières sous forme de feuilles ou de nappes par pliage, enroulement, cintrage ou par des opérations similaires par enroulement hélicoïdal
• G01N 27/327 - Électrodes biochimiques
• G01N 27/403 - Ensembles de cellules et d'électrodes

Abrégé

A method for continuous epitaxy of a carbon film, including the following steps: Si, providing a foil, wherein the foil is selected from a nickel foil or a copper-nickel alloy foil and has a first surface and a second surface; and S2, using the foil as a substrate and placing it on a solid carbon source, wherein the first surface of the foil is positioned close to the solid carbon source, while the second surface of the foil is positioned away from the solid carbon source, and then heating the foil and the solid carbon source, so that a carbon film is formed by continuous epitaxy on the second surface of the foil.

Classes IPC  ?

• C01B 32/205 - Préparation
• C30B 1/02 - Croissance des monocristaux à partir de l'état solide par traitement thermique, p. ex. recuit sous contrainte

Abrégé

The present application discloses an external-cavity diode laser based on a Voigt anomalous dispersion atomic optical filter. The laser includes: a laser diode coated with an anti-reflective coating, where the laser diode is provided with a temperature control module thereon; a collimation module, configured to perform collimation and expanding for the laser diode; the Voigt anomalous dispersion atomic optical filter, configured to filter laser light emitted from the laser diode, where a spectrum of laser light output from the laser depends on a transmission spectrum of the atomic optical filter; a reflective cavity mirror, configured to reflect the laser light filtered by the atomic optical filter back into a resonant cavity to form oscillation and produce stable laser light; a piezoelectric ceramic, assembled with the reflective cavity mirror and configured to fine-tune a cavity length of the laser to achieve tuning of the laser light.

Classes IPC  ?

• H01S 5/14 - Lasers à cavité externe
• H01S 3/08 - Structure ou forme des résonateurs optiques ou de leurs composants
• H01S 3/105 - Commande de l'intensité, de la fréquence, de la phase, de la polarisation ou de la direction du rayonnement, p. ex. commutation, ouverture de porte, modulation ou démodulation par commande de la position relative ou des propriétés réfléchissantes des réflecteurs de la cavité
• H01S 5/00 - Lasers à semi-conducteurs
• H01S 5/02326 - Dispositions pour le positionnement relatif des diodes laser et des composants optiques, p. ex. rainures dans le support pour fixer des fibres optiques ou des lentilles
• H01S 5/024 - Dispositions pour la gestion thermique
• H01S 5/028 - Revêtements

Abrégé

Disclosed are a diabetes sensor, a method for manufacturing the diabetes sensor, and a closed-loop control system. The diabetes sensor includes a substrate, a microneedle array arranged on one side of the substrate, and a plurality of electrodes covering the microneedle array and the substrate, wherein the microneedle array includes a plurality of microneedles; and the plurality of electrodes includes an electrochemical sensor and a reverse iontophoresis device; the electrochemical sensor being configured to detect glucose molecules in interstitial fluid and generate an electrical signal; and the reverse iontophoresis device being configured to generate a reverse iontophoresis effect to attract glucose molecules in a deep skin layer to an upper part of dermis where needle tips of the microneedles are located.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
• A61B 5/1486 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang en utilisant des procédés chimiques ou électrochimiques, p. ex. par des moyens polarographiques en utilisant des électrodes enzymatiques, p. ex. avec oxydase immobilisée
• A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau

Abrégé

The present invention relates to the technical filed of biomedicine, and relates to a Tmem52 protein fragment, an encoding gene, a recombinant vector, a recombinant microorganism, and a use thereof. The Tmem52 protein fragment can reduce weight, increase basal metabolic rate, prevent and treat obesity, increase insulin sensitivity, improve blood glucose regulation ability, prevent and treat diabetes, reduce serum triglyceride level, and prevent and treat hyperlipidemia, and can also be used for treating obesity and related diseases, such as diabetes and hyperlipidemia.

Classes IPC  ?

• C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
• A61P 9/10 - Médicaments pour le traitement des troubles du système cardiovasculaire des maladies ischémiques ou athéroscléreuses, p. ex. médicaments antiangineux, vasodilatateurs coronariens, médicaments pour le traitement de l'infarctus du myocarde, de la rétinopathie, de l'insuffisance cérébro-vasculaire, de l'artériosclérose rénale
• A61P 9/00 - Médicaments pour le traitement des troubles du système cardiovasculaire
• A61P 1/16 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des troubles de la vésicule biliaire ou du foie, p. ex. protecteurs hépatiques, cholagogues, cholélitholytiques
• A61P 3/00 - Médicaments pour le traitement des troubles du métabolisme
• A61P 35/00 - Agents anticancéreux
• C12N 15/12 - Gènes codant pour des protéines animales
• C12N 15/70 - Vecteurs ou systèmes d'expression spécialement adaptés à E. coli
• C12N 1/21 - BactériesLeurs milieux de culture modifiés par l'introduction de matériel génétique étranger
• A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
• A61P 3/04 - AnorexigènesMédicaments de l'obésité
• A61P 3/06 - Antihyperlipémiants
• A61P 3/10 - Médicaments pour le traitement des troubles du métabolisme de l'homéostase du glucose de l'hyperglycémie, p. ex. antidiabétiques

Abrégé

The present disclosure provides a random matrix vector multiply-add operation system and an operation method thereof. The operation system comprises an input bit stream generation unit, a weighting bit stream generation unit and a memory array; the input bit stream generation unit is used for generating, according to preset input vectors, pulse sequences of corresponding input random bit streams, and the weighting bit stream generation unit is used for generating, according to a preset weighting matrix, pulse sequences of corresponding weighting random bit streams, the pulse sequences of the input random bit streams and the pulse sequences of the weighting random bit streams being respectively applied to word lines and bit lines of the memory array; multiply-add results of the input random bit streams and the weighting random bit streams at memory devices of the memory array are stored in conductivity values of the corresponding memory devices. The random matrix vector multiply-add operation system and the operation method thereof provided by the present disclosure can solve the problems of low operation speed, low parallel degree and large hardware overheads of traditional multiply-add computing units in stochastic computing.

Classes IPC  ?

• G06F 7/544 - Méthodes ou dispositions pour effectuer des calculs en utilisant exclusivement une représentation numérique codée, p. ex. en utilisant une représentation binaire, ternaire, décimale utilisant des dispositifs n'établissant pas de contact, p. ex. tube, dispositif à l'état solideMéthodes ou dispositions pour effectuer des calculs en utilisant exclusivement une représentation numérique codée, p. ex. en utilisant une représentation binaire, ternaire, décimale utilisant des dispositifs non spécifiés pour l'évaluation de fonctions par calcul

Abrégé

A thermochromic cholesteric liquid crystal material, which is formed by mixing a parent liquid crystal and a chiral agent, wherein the parent liquid crystal comprises a mixture A and a mixture B, which are both hydrogen bond liquid crystals, wherein the mixture A has a clearing point of 120ºC to 180ºC, and is a mixture of at least two benzoic acid derivatives; and the mixture B has a crystallization point of -30ºC to 0ºC, and is a mixture of at least two cyclohexanecarboxylic acid derivatives. The cholesteric liquid crystal material of the present invention has the characteristics of high sensitivity and a wide color gamut, can achieve continuous change of a structural color from red to blue within a very narrow temperature interval, and can optimally achieve the change of the structural color from red to blue within 3-5ºC, which is more sensitive than a traditional cholesteric liquid crystal; moreover, the cholesteric liquid crystal material has a wide color change range, and has large application potential in the aspects of temperature display, anti-counterfeiting techniques, etc.

Classes IPC  ?

• C09K 9/02 - Substances organiques devenant sombres
• C09K 19/36 - Composés stéroïdes formant des cristaux liquides

Abrégé

The present application provides a two-dimensional network-on-chip structure, a routing method therefor, an apparatus, a device, and a storage medium, and relates to the technical field of communication. The two-dimensional network-on-chip structure comprises: a plurality of processing cores, any one of the processing cores comprising a routing node, the routing node comprising five input distributors and five output arbiters; any one of the input distributors is used for sending to a target output arbiter a target data packet transmission request, the target output arbiter is determined on the basis of a target routing direction, and the target routing direction is determined on the basis of destination address information of the target data packet and an X/Y-dimension sequence routing policy; the target output arbiter is used for responding to the transmission request so as to transmit the target data packet to a target position corresponding to the target output arbiter, the target position comprising one of four adjacent routing nodes or a pulse data packet encoding and decoding interface. The present application avoids deadlocks and increases the throughput of the two-dimensional network-on-chip structure.

Classes IPC  ?

• H04L 49/112 - Commande de la commutation, p. ex. par arbitrage

Abrégé

Provided in the present application are a biological credible neuron calculation circuit and a calculation method. The circuit carries out an operation on a membrane level and a neural network pulse signal at the previous moment by means of a synaptic integration module, a leakage integration module, and a threshold comparison and pulse firing module, so as to acquire a membrane level at the current moment, and generate a pulse signal according to the membrane level at the current moment. Compared with a conventional digital-analog hybrid design which excessively pursues accurate neuromorphic behaviors, and a conventional digital design which excessively pursues extremely low calculation complexity, the biological credible neuron calculation circuit in the present application makes a better compromise between biological confidence and calculation complexity, such that richer neuron dynamics behaviors can be realized at a relatively low hardware cost, the maximum-scale enhancement of LIF neuron integration and synaptic integration is realized, and more complex and more diverse neuromorphic brain-like applications can be deployed.

Classes IPC  ?

• G06N 3/06 - Réalisation physique, c.-à-d. mise en œuvre matérielle de réseaux neuronaux, de neurones ou de parties de neurone

Abrégé

Provided in the present application are a brain-like synaptic learning method, and a neuromorphic hardware system based on a brain-like technique. The method comprises: determining a spike pair generated by means of a pre-synaptic neuron and post-synaptic neuron in a brain-like synaptic learning circuit, wherein the spike pair comprises an input spike generated by means of the pre-synaptic neuron and an output spike generated by means of the post-synaptic neuron; on the basis of the spike pair, determining an STDP mechanism corresponding to the spike pair, and a synaptic weight corresponding to the STDP mechanism; and on the basis of the spike pair and the synaptic weight, performing STDP learning corresponding to the brain-like synaptic learning circuit, wherein the STDP mechanism is a spike-timing-dependent plasticity mechanism, and a pre-synaptic spike and post-synaptic spike of the spike pair correspond to a long-term potentiation process or long-term depression process in the STDP mechanism according to a time order relationship. By means of the present application, online learning of brain-like intelligence is improved, and the environmental adaptation characteristic of brain-like computing being widely applicable is exploited.

Classes IPC  ?

• G06N 3/06 - Réalisation physique, c.-à-d. mise en œuvre matérielle de réseaux neuronaux, de neurones ou de parties de neurone

Abrégé

The present application provides a circuit of on-chip network and an electronic device. The circuit of on-chip network comprises a five-layer routing module circuit and a resource circuit. The routing module circuit comprises five routing layers. The resource circuit comprises a plurality of brain-like chip processing cores. Four routing nodes connected to a first routing layer in the routing module circuit to serve as a second routing layer; each routing node in the second routing layer is connected to four routing nodes to serve as a third routing layer; each routing node in the third routing layer is connected to four routing nodes to serve as a fourth routing layer; each routing node in the fourth routing layer is connected to four routing nodes to serve as a fifth routing layer; and each routing node in the fifth routing layer is connected to the four brain-like chip processing cores. Routing nodes closer to a root routing node have a larger number of parallel channels. According to the present application, excessive delay of the grid structure is avoided and the congestion problem of the circuit of on-chip network is alleviated.

Classes IPC  ?

• G06F 15/173 - Communication entre processeurs utilisant un réseau d'interconnexion, p. ex. matriciel, de réarrangement, pyramidal, en étoile ou ramifié

Abrégé

The present application provides a digital neuromorphic computing processor and a computing method. The processor acquires neural network input data by means of a data packet routing module, a data caching module, a synaptic connection storage module, and a neuron computing module, so as to determine a neural network type of the neural network input data, then performs operation on an input pulse neural network pulse signal or an artificial neural network activation value according to a pre-stored neural network synaptic weight value and neuron parameters, and outputs an operation result according to the neural network type. Existing computational processors based on model conversion methods require model algorithm conversion, resulting in significant loss of precision. The present application can be applied to both pulse neural networks and artificial neural networks, and does not require model algorithm conversion, so that the loss of precision in a process of model conversion is avoided.

Classes IPC  ?

• G06N 3/063 - Réalisation physique, c.-à-d. mise en œuvre matérielle de réseaux neuronaux, de neurones ou de parties de neurone utilisant des moyens électroniques

Abrégé

The present application provides a sparse spiking neural network accelerator based on a ping-pong architecture. Compressed weight values are transmitted to a compressed weight calculation module, and a sparse spike detection module is used for extracting an effective spike index from a spike input signal, thereby preventing subsequent spike signals from all participating in an operation, and reducing the amount of calculation; and the compressed weight calculation module accumulates a non-zero value among the compressed weight values to a membrane potential of a neuron according to the effective spike index, and finally decides whether to emit a spike or not. Compared with a traditional technical solution that all synapses in a synaptic crossbar array are activated and participate in an operation, in the present application, only a synaptic weight corresponding to the effective spike index is activated, and other synapses do not participate in the operation, thereby reducing the amount of calculation, reducing the operating power consumption of the whole chip, and improving the operating speed, energy efficiency and area efficiency of a spiking neural network.

Classes IPC  ?

• G06N 3/063 - Réalisation physique, c.-à-d. mise en œuvre matérielle de réseaux neuronaux, de neurones ou de parties de neurone utilisant des moyens électroniques

Abrégé

A compute-in-memory (CIM) circuit and a control method thereof. The CIM circuit includes a memory array. The memory array comprises n1 memory blocks arranged in sequence from top to bottom, and each memory block comprises n2 rows of memory-cell rows arranged in sequence, wherein n1≥2, n2≥1. Each odd memory block and an adjacent even memory block arranged therebelow form a memory group. Each memory group comprises n2 pairs of memory-cell rows, and a k-th pair of memory-cell rows in each memory group includes a k-th memory-cell row and a (2n2+1−k)-th memory-cell row in the corresponding memory group, where 1≤k≤n2. The memory array is divided into n2 memory subarrays configured to be turned on in sequence for calculation, wherein a k-th memory subarray includes the k-th pair of memory-cell rows in each memory group.

Classes IPC  ?

• G11C 7/16 - Emmagasinage de signaux analogiques dans des mémoires numériques utilisant une disposition comprenant des convertisseurs analogiques/numériques [A/N], des mémoires numériques et des convertisseurs numériques/analogiques [N/A]
• G11C 7/10 - Dispositions d'interface d'entrée/sortie [E/S, I/O] de données, p. ex. circuits de commande E/S de données, mémoires tampon de données E/S

Abrégé

Provided in the present invention are an ASP-ELP for reducing immunogenicity and enhancing an anti-tumor effect, and a preparation method therefor and the use thereof. According to the present invention, for the first time, the artificial intelligence tool AlphaFold2 is used to fuse ELPs of different lengths and compositions with ASP. The designed ASP-ELPs have multiple advantages compared with bulk drug asparaginase ASP and long-acting asparaginase PEG-ASP. In vivo and in vitro experimental results show that the ASP-ELPs are superior to the long-acting asparaginase in the aspects of enzyme activity retention rate, storage stability, pharmacokinetics, immunogenicity, biosafety, anti-cancer efficacy, etc. The present invention not only provides a new design method for pharmaceutical research and development of a protein-macromolecular polymer on the basis of artificial intelligence-assisted design, but also shows that the ASP-ELPs are a new efficient therapy for treating hematological malignancies.

Classes IPC  ?

• A61K 47/64 - Conjugués médicament-peptide, médicament-protéine ou médicament-acide polyaminé, c.-à-d. l’agent de modification étant un peptide, une protéine ou un acide polyaminé lié par covalence ou complexé à un agent thérapeutiquement actif
• C07K 19/00 - Peptides hybrides
• C12N 15/09 - Technologie d'ADN recombinant
• A61K 35/00 - Préparations médicinales contenant des substances ou leurs produits de réaction de constitution non déterminée

Abrégé

The present application provides a weighted summation compute-in-memory circuit and a memory. The circuit is provided with a first array and a second array which are symmetrically distributed, and a peripheral circuit, wherein when the first array is used to perform compute-in-memory, firstly, the first array and the second array are disconnected by means of the peripheral circuit, and bitwise matrix vector multiplication is executed by means of the first array; and then, the first array and the second array are connected by means of the peripheral circuit, and the first array and the second array form a switched capacitor circuit, so as to acquire, by means of the second array, analog summation and analog weighted summation operations corresponding to pulse signals, and output operation results. By using the weighted summation compute-in-memory circuit and the memory, the voltage stability on a bit line can be maintained, and the number of times that an ADC is started is reduced, thereby improving the energy efficiency and area efficiency of a system.

Classes IPC  ?

• G06N 3/065 - Moyens analogiques

Abrégé

Provided is a genetically engineered nitrogen-fixing bacterium comprising conditionally activated ammonium excretion regulated by an environmental condition. Also provided is a composition comprising the bacterium as well as use of the bacterium or composition for providing fixed atmospheric nitrogen to crop plants in the fields.

Classes IPC  ?

• C12N 1/21 - BactériesLeurs milieux de culture modifiés par l'introduction de matériel génétique étranger
• C05F 11/08 - Engrais organiques comportant l'addition de cultures bactériennes, de mycélium ou similaires
• C12N 15/52 - Gènes codant pour des enzymes ou des proenzymes
• C07K 14/195 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries
• C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteursVecteurs Utilisation d'hôtes pour ceux-ciRégulation de l'expression
• C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
• C12R 1/19 - Escherichia coli
• C12R 1/22 - Klebsiella

Abrégé

MEMEME has five cap modifications at each end of a full thio-sequence, and the carrier consists of a nucleoside phospholipid TPS or CPS, a cationic lipid CLDA and an auxiliary lipid DSPE-PEG. In the present invention, by means of adjusting the ratio in the preparation and optimizing the solvent of the preparation, a novel anti-liver cancer pharmaceutical preparation having a great clinical application potential is obtained. After low-dose and low-frequency intravenous administration to mice, the preparation significantly inhibits the growth of liver cancer in mice, and exhibits an ideal sustained-release/long-acting anti-cancer effect, with an efficacy superior to that of a CT102/DNCA/CLD/PEG preparation. The present invention establishes a foundation for the wide clinical application of anti-liver cancer antisense nucleic acid drugs, and also has wide application prospects in the field of gene therapy.

Classes IPC  ?

• A61K 31/7105 - Acides ribonucléiques naturels, c.-à-d. contenant uniquement des riboses liés à l'adénine, la guanine, la cytosine ou l'uracile et ayant des liaisons 3'-5' phosphodiester
• A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
• A61K 47/24 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant des atomes autres que des atomes de carbone, d'hydrogène, d'oxygène, d'halogènes, d'azote ou de soufre, p. ex. cyclométhicone ou phospholipides
• A61K 47/20 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant du soufre, p. ex. sulfoxyde de diméthyle [DMSO], docusate, laurylsulfate de sodium ou acides aminosulfoniques
• A61P 35/00 - Agents anticancéreux
• A61P 1/16 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des troubles de la vésicule biliaire ou du foie, p. ex. protecteurs hépatiques, cholagogues, cholélitholytiques

Abrégé

The present application provides a method for preventing metallic copper from corrosion and a metallic copper anti-corrosion structure, belonging to the technical field of metal anti-corrosion. The method for preventing metallic copper from corrosion comprises forming a graphene layer with a thickness of at least 2 atomic layers on a surface of a copper matrix. The method for preventing metallic copper from corrosion of the present application can weaken charge transfer between corrosive substances and the copper matrix by means of formation of the graphene layer with the thickness of at least 2 atomic layers on the surface of the copper matrix, so that the copper matrix is not prone to an electrochemical reaction via the graphene layer on the surface, thereby improving the anti-corrosion performance of the copper matrix.

Classes IPC  ?

• C23C 16/26 - Dépôt uniquement de carbone

Abrégé

This invention relates to an unnatural amino acid-based ionic liquid, and preparation methods and applications thereof. It specifically provides a combination for preparing a protein comprising an unnatural amino acid, comprising: (1) one or more aminoacyl-tRNA synthetases capable of binding to a mutated tRNA; (2) one or more mutated tRNAs with an anti-codon loop mutated to complement a termination codon; (3) various unnatural amino acid-based ionic liquids. The combination can be used for recombinant expression of a target protein comprising an unnatural amino acid. The unnatural amino acid-based ionic liquids can improve the read-through efficiency of the genetic codon expansion system for a premature termination codon (PTC) and/or the incorporation efficiency of unnatural amino acids.

Classes IPC  ?

• C12P 21/00 - Préparation de peptides ou de protéines
• C12N 9/00 - Enzymes, p. ex. ligases (6.)ProenzymesCompositions les contenantProcédés pour préparer, activer, inhiber, séparer ou purifier des enzymes

Abrégé

A chemiluminescent lateral flow immunoassay method is provided for reducing cross reactions and false positives when detecting protein analytes. The detection method involves a lateral flow immunoassay strip, the strip includes a sample pad, a conjugate pad, a nitrocellulose membrane, and an absorbent pad. The capture antibody of the analyte on the nitrocellulose membrane is used as the test line, and the IgG antibody is used as the control line. The lateral flow immunoassay is performed on the strip by the Au nanoparticle-antibody-horseradish peroxidase-polyethylene glycol (AuNP-Ab-RP-PEG) conjugate to detect the specific analyte. During the detection, the conjugate is prepared in the strip and then added to the analyte for detection, or the conjugate is mixed with the analyte and then added to the strip for detection.

Classes IPC  ?

• G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
• G01N 21/76 - ChimioluminescenceBioluminescence
• G01N 33/532 - Production de composés immunochimiques marqués

Abrégé

A methane sensor includes a substrate, a conductive connection electrode, and a sensing electrode, the conductive connection electrode is arranged on the substrate, and the sensing electrode is covered on the conductive connection electrode, the sensing electrode is a layer of conductive polymer film, and the conductive connection electrode is coated with an insulating layer in addition to the sensing area. The sensing electrode adopts one of poly (3,4-ethylenedioxythiophene): poly (styrene sulfonic acid), polyaniline, polythiophene and polypyrrole, which is made into a film by a screen printing, inkjet printing or other coating method in the form of liquid or paste. The present invention adopts the above methane sensor, with a small and stable sensor, realizing sensitive and rapid detection of methane, and solving the problems of high power consumption of methane sensors in the prior art, high working temperature, expensive and bulky casing of the equipment, and high price.

Classes IPC  ?

• G01N 27/30 - Électrodes, p. ex. électrodes pour testsDemi-cellules
• G01N 33/00 - Recherche ou analyse des matériaux par des méthodes spécifiques non couvertes par les groupes

Abrégé

Provided is a composition used for obtaining and/or culturing a human intestinal tissue-derived organoid or a human colorectal tumor tissue-derived organoid, the composition comprising an ALK inhibitor, a WNT agonist, an EGF agonist, and an FGF agonist. Further provided is a composition used for obtaining and/or culturing an organoid having a proliferative intestinal crypt tissue feature and/or an "intermediate plastic state" cell, the composition comprising an ALK inhibitor, a WNT agonist, an EGF agonist, an EBP1 and IκB dual regulator, and a P38 inhibitor.

Classes IPC  ?

• C12N 5/071 - Cellules ou tissus de vertébrés, p. ex. cellules humaines ou tissus humains
• C12N 5/09 - Cellules tumorales

Abrégé

Provided is a composition for obtaining and/or culturing human normal-tissue-derived organoids or human tumor-tissue-derived organoids, the composition including ALK inhibitors (e.g., LDN214117), WNT agonists (e.g., CHIR), EGF agonists (e.g., EGF) and FGF agonists (e.g., FGF2), and optionally IKKε inhibitors.

Classes IPC  ?

• C12N 5/071 - Cellules ou tissus de vertébrés, p. ex. cellules humaines ou tissus humains
• C12N 5/09 - Cellules tumorales
• C12Q 1/02 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des micro-organismes viables

Abrégé

A high-density ferroelectric memory, and a manufacturing method therefor and an application thereof, relating to the field of semiconductor memories. The memory consists of multiple memory cells arranged in an array, and two sides of the array of the memory cells are connected by substantially orthogonal word lines and bit lines. Each memory cell has a stack structure of a top electrode, a resistive dielectric layer, an intermediate metal layer, a ferroelectric dielectric layer, and a bottom electrode, and the structure is electrically equivalent to a ferroelectric capacitor and a resistive selector connected in series. By regulating the RC delay of the memory cells, the voltage distributed to a ferroelectric capacitor in an unselected cell is reduced, so that the disturbance to the unselected cell is reduced; additionally, the capacitance value of the ferroelectric capacitor is stable, and the effect of a disturbance voltage can be effectively reduced by means of RC regulation. The present invention improves the memory window of a memory and reduces the bit error rate, without increasing additional area overhead.

Classes IPC  ?

• H10B 53/30 - Dispositifs RAM ferro-électrique [FeRAM] comprenant des condensateurs ferro-électriques de mémoire caractérisés par la région noyau de mémoire

Abrégé

Provided are methods for editing RNA by introducing a deaminase-recruiting RNA in a host cell for deamination of an adenosine in a target RNA. Further provided are deaminase-recruiting RNAs used in the RNA editing methods and compositions and kits comprising the same.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• A61P 3/06 - Antihyperlipémiants
• C12N 9/00 - Enzymes, p. ex. ligases (6.)ProenzymesCompositions les contenantProcédés pour préparer, activer, inhiber, séparer ou purifier des enzymes
• C12N 9/80 - Hydrolases (3.) agissant sur les liaisons carbone-azote autres que les liaisons peptidiques (3.5) agissant sur les liaisons amides des amides aliphatiques

Abrégé

A high-speed and high-density ferroelectric memory, and a manufacturing method therefor and an application thereof, relating to the field of semiconductor memories. The memory consists of multiple memory cells arranged in an array, and two sides of the array of the memory cells are connected by substantially orthogonal word lines and bit lines. Each memory cell has a structure in which a top electrode, a variable capacitance dielectric layer, an intermediate metal layer, a ferroelectric dielectric layer, and a bottom electrode are stacked, and the structure is electrically equivalent to a ferroelectric capacitor and a variable capacitance selector connected in series. By regulating a voltage distribution relationship among the memory cells, the voltage distributed to a ferroelectric capacitor in an unselected cell is reduced, so that the disturbance to the unselected cell is reduced; additionally, the serial connection of capacitors reduces the RC delay of the memory cells and improves the memory access speed. Therefore, the present invention reduces the disturbance to an unselected cell, improves the memory window of a memory, reduces the bit error rate of the memory, and improves the memory access speed, without increasing additional area overhead.

Classes IPC  ?

• H10B 53/30 - Dispositifs RAM ferro-électrique [FeRAM] comprenant des condensateurs ferro-électriques de mémoire caractérisés par la région noyau de mémoire
• H10B 53/10 - Dispositifs RAM ferro-électrique [FeRAM] comprenant des condensateurs ferro-électriques de mémoire caractérisés par la configuration vue du dessus
• H10N 97/00 - Dispositifs électriques à l’état solide à film mince ou à film épais, non prévus ailleurs
• G11C 11/22 - Mémoires numériques caractérisées par l'utilisation d'éléments d'emmagasinage électriques ou magnétiques particuliersÉléments d'emmagasinage correspondants utilisant des éléments électriques utilisant des éléments ferro-électriques

Abrégé

Provided in the present application are an end-edge-cloud coordination system and method based on a digital retina, and a device. The coordination system may include, but is not limited to, a front-end device, an edge device, and a cloud device. The front-end device is used for extracting, from collected video data, features having universality, and is used for generating analysis and recognition tasks on the basis of the features. The front-end device is also used for processing the analysis and recognition tasks, so as to obtain a first intermediate result to be sent to the edge device. The edge device is used for processing the analysis and recognition tasks on the basis of the first intermediate result, so as to obtain a second intermediate result to be sent to the cloud device. The cloud device is used for processing the analysis and recognition tasks on the basis of the second intermediate result, so as to obtain an analysis and recognition result for video data. By means of a coordination system architecture provided in the present application, computing coordination, feature coordination, and model coordination can be achieved. Therefore, the technical solution of the present application has the advantages of high efficiency, etc., and is well suited for processing a large amount of video data.

Classes IPC  ?

• G06V 10/44 - Extraction de caractéristiques locales par analyse des parties du motif, p. ex. par détection d’arêtes, de contours, de boucles, d’angles, de barres ou d’intersectionsAnalyse de connectivité, p. ex. de composantes connectées
• G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux

Abrégé

Disclosed are an optical instrument, an imaging system, and an imaging method for a miniature multi-photon microscope, relating to the optical configuration field. The optical instrument is configured to have a fluorescence excitation optical path and a fluorescence collection optical path. The optical instrument includes a condenser, and the condenser includes a first lens group and a second lens group separately disposed. The first lens group is located in the fluorescence collection optical path, the second lens group is located in the fluorescence excitation optical path and the fluorescence collection optical path. A relative distance the second lens group and a miniature objective is less than a first preset distance threshold. A collection efficiency of scattered fluorescence of the miniature multi-photon microscope may be improved, thereby improving an imaging signal-to-noise ratio and an imaging depth when a sample to be test with a scattering characteristic is observed.

Classes IPC  ?

• G02B 21/00 - Microscopes
• G02B 21/08 - Condensateurs