Abstract

The present invention relates to dyes with pH-dependent absorption and fluorescence for pH detection and their applications in biology, medicine and theranostic. In particular, the present invention relates to compounds of the general formulae (I)-(IV), that show pH dependent absorption and fluorescence spectra as well as pH dependent fluorescence quantum yield, methods for their preparation and their application as pH-sensors and labeling groups for the detection of analytes.

IPC Classes  ?

• C09B 1/00 - Dyes with an anthracene nucleus not condensed with any other ring
• C09B 3/82 - Preparation from starting materials already containing the condensed anthracene nucleus
• C09B 15/00 - Acridine dyes

Goods & Services

Chemicals for use in industry and science; chemical reagents for non-medical purposes; reagents for research purposes; research reagents and preparations, except for medical or veterinary use; research preparations used in science; chemical reagents and diagnostic preparations for use in research laboratories and for use in industry; fluorescent dyes and fluorescent labels for applications in industry and science; assay reagents for use in research, quality control, diagnostic use; aptamers for use in research, quality control; affinity reagents for use in research or quality control; supramolecular host-guest systems for use in research or quality control; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for research use; kits comprising a combination of any of the aforesaid chemical reagents, research reagents and preparations, assay reagents, affinity reagents, supramolecular host-guest systems, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents and inactivation agents, all for industrial, scientific and research use. Research preparations, namely antibodies or nucleic acid probes, for the investigation of disease models; preparations for medical and veterinary research; reagents containing primary antibodies for research use; chemical reagents and medical preparations for research purposes; clinical research reagents; chemical reagents for medical or veterinary research purposes, namely reagents for immuno-histochemistry detection and in situ-hybridisation detection; in situ-hybridisation probes for medical research purposes; epitope retrieval solutions for medical research purposes; enzymes and enzyme preparations for medical research purposes; histological dye and stain solutions for medical research purposes; dewaxing and wash buffers used with the aforementioned preparations; fluorescent dyes and fluorescent labels for diagnostic use; assay reagents for diagnostic use; aptamers for diagnostic use; affinity reagents for diagnostic use; supramolecular host-guest systems for diagnostic use; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for diagnostic use; kits comprising a combination of any of the aforesaid research reagents, preparations for medical and veterinary research, clinical research reagents, in situ-hybridisation probes, epitope retrieval solutions, enzymes and enzyme preparations, histological dyes and stain solutions, dewaxing and wash buffers, fluorescent dyes and fluorescent labels, assay reagents, aptamers, affinity reagents, supramolecular host-guest systems, reagents containing primary antibodies, affimers, or other affinity reagents, nucleic acid probes, non-optically detectable labels, blocking agents and inactivation agents, all for diagnostic and medical research purposes.

Goods & Services

Chemicals for use in industry and science; chemical reagents for non-medical purposes; reagents for research purposes; research reagents and preparations, except for medical or veterinary use; research preparations used in science; chemical reagents and diagnostic preparations for use in research laboratories and for use in industry; fluorescent dyes and fluorescent labels for applications in industry and science; assay reagents for use in research, quality control, diagnostic use; aptamers for use in research, quality control; affinity reagents for use in research or quality control; supramolecular host-guest systems for use in research or quality control; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for research use; kits comprising a combination of any of the aforesaid chemical reagents, research reagents and preparations, assay reagents, affinity reagents, supramolecular host-guest systems, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents and inactivation agents, all for industrial, scientific and research use. Research preparations, namely antibodies or nucleic acid probes, for the investigation of disease models; preparations for medical and veterinary research; reagents containing primary antibodies for research use; chemical reagents and medical preparations for research purposes; clinical research reagents; chemical reagents for medical or veterinary research purposes, namely reagents for immuno-histochemistry detection and in situ-hybridisation detection; in situ-hybridisation probes for medical research purposes; epitope retrieval solutions for medical research purposes; enzymes and enzyme preparations for medical research purposes; histological dye and stain solutions for medical research purposes; dewaxing and wash buffers used with the aforementioned preparations; fluorescent dyes and fluorescent labels for diagnostic use; assay reagents for diagnostic use; aptamers for diagnostic use; affinity reagents for diagnostic use; supramolecular host-guest systems for diagnostic use; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for diagnostic use; kits comprising a combination of any of the aforesaid research reagents, preparations for medical and veterinary research, clinical research reagents, in situ-hybridisation probes, epitope retrieval solutions, enzymes and enzyme preparations, histological dyes and stain solutions, dewaxing and wash buffers, fluorescent dyes and fluorescent labels, assay reagents, aptamers, affinity reagents, supramolecular host-guest systems, reagents containing primary antibodies, affimers, or other affinity reagents, nucleic acid probes, non-optically detectable labels, blocking agents and inactivation agents, all for diagnostic and medical research purposes.

Goods & Services

Chemicals for use in industry and science; chemical reagents for non-medical purposes; research reagents and preparations, except for medical or veterinary use; research preparations used in science; chemical reagents and diagnostic preparations for use in research laboratories and for use in industry; fluorescent dyes and fluorescent labels for applications in industry and science; assay reagents for use in research, quality control, diagnostic use; aptamers for use in research, quality control; affinity reagents for use in research or quality control; supramolecular host-guest systems for use in research or quality control; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for research use; reagents for research purposes; kits comprising a combination of any of the aforesaid chemical reagents, research reagents and preparations, assay reagents, affinity reagents, supramolecular host-guest systems, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents and inactivation agents, all for industrial, scientific and research use. Research preparations, namely antibodies or nucleic acid probes, for the investigation of disease models; preparations for medical and veterinary research; reagents containing primary antibodies for research use; chemical reagents and medical preparations for research purposes; clinical research reagents; chemical reagents for medical or veterinary research purposes, namely reagents for immuno-histochemistry detection and in situ-hybridisation detection; in situ-hybridisation probes for medical research purposes; epitope retrieval solutions for medical research purposes; enzymes and enzyme preparations for medical research purposes; histological dye and stain solutions for medical research purposes; dewaxing and wash buffers used with the aforementioned preparations; fluorescent dyes and fluorescent labels for diagnostic use; assay reagents for diagnostic use; aptamers for diagnostic use; affinity reagents for diagnostic use; supramolecular host-guest systems for diagnostic use; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for diagnostic use; kits comprising a combination of any of the aforesaid research reagents, preparations for medical and veterinary research, clinical research reagents, in situ-hybridisation probes, epitope retrieval solutions, enzymes and enzyme preparations, histological dyes and stain solutions, dewaxing and wash buffers, fluorescent dyes and fluorescent labels, assay reagents, aptamers, affinity reagents, supramolecular host-guest systems, reagents containing primary antibodies, affimers, or other affinity reagents, nucleic acid probes, non-optically detectable labels, blocking agents and inactivation agents, all for diagnostic and medical research purposes.

Goods & Services

Chemicals for use in industry and science; chemical reagents for non-medical purposes; reagents for research purposes; research reagents and preparations, except for medical or veterinary use; research preparations used in science; chemical reagents and diagnostic preparations for use in research laboratories and for use in industry; fluorescent dyes and fluorescent labels for applications in industry and science; assay reagents for use in research, quality control, diagnostic use; aptamers for use in research, quality control; affinity reagents for use in research or quality control; supramolecular host-guest systems for use in research or quality control; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for research use; kits comprising a combination of any of the aforesaid chemical reagents, research reagents and preparations, assay reagents, affinity reagents, supramolecular host-guest systems, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents and inactivation agents, all for industrial, scientific and research use. Research preparations, namely antibodies or nucleic acid probes, for the investigation of disease models; preparations for medical and veterinary research; reagents containing primary antibodies for research use; chemical reagents and medical preparations for research purposes; clinical research reagents; chemical reagents for medical or veterinary research purposes, namely reagents for immuno-histochemistry detection and in situ-hybridisation detection; in situ-hybridisation probes for medical research purposes; epitope retrieval solutions for medical research purposes; enzymes and enzyme preparations for medical research purposes; histological dye and stain solutions for medical research purposes; dewaxing and wash buffers used with the aforementioned preparations; fluorescent dyes and fluorescent labels for diagnostic use; assay reagents for diagnostic use; aptamers for diagnostic use; affinity reagents for diagnostic use; supramolecular host-guest systems for diagnostic use; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for diagnostic use; kits comprising a combination of any of the aforesaid research reagents, preparations for medical and veterinary research, clinical research reagents, in situ-hybridisation probes, epitope retrieval solutions, enzymes and enzyme preparations, histological dyes and stain solutions, dewaxing and wash buffers, fluorescent dyes and fluorescent labels, assay reagents, aptamers, affinity reagents, supramolecular host-guest systems, reagents containing primary antibodies, affimers, or other affinity reagents, nucleic acid probes, non-optically detectable labels, blocking agents and inactivation agents, all for diagnostic and medical research purposes.

Goods & Services

Chemicals for use in industry and science; chemical reagents for non-medical purposes; reagents for research purposes; research reagents and preparations, except for medical or veterinary use; research preparations used in science; chemical reagents and diagnostic preparations for use in research laboratories and for use in industry; fluorescent dyes and fluorescent labels for applications in industry and science; assay reagents for use in research, quality control, diagnostic use; aptamers for use in research, quality control; affinity reagents for use in research or quality control; supramolecular host-guest systems for use in research or quality control; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for research use; kits comprising a combination of any of the aforesaid chemical reagents, research reagents and preparations, assay reagents, affinity reagents, supramolecular host-guest systems, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents and inactivation agents, all for industrial, scientific and research use. Research preparations, namely antibodies or nucleic acid probes, for the investigation of disease models; preparations for medical and veterinary research; reagents containing primary antibodies for research use; chemical reagents and medical preparations for research purposes; clinical research reagents; chemical reagents for medical or veterinary research purposes, namely reagents for immuno-histochemistry detection and in situ-hybridisation detection; in situ-hybridisation probes for medical research purposes; epitope retrieval solutions for medical research purposes; enzymes and enzyme preparations for medical research purposes; histological dye and stain solutions for medical research purposes; dewaxing and wash buffers used with the aforementioned preparations; fluorescent dyes and fluorescent labels for diagnostic use; assay reagents for diagnostic use; aptamers for diagnostic use; affinity reagents for diagnostic use; supramolecular host-guest systems for diagnostic use; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for diagnostic use; kits comprising a combination of any of the aforesaid research reagents, preparations for medical and veterinary research, clinical research reagents, in situ-hybridisation probes, epitope retrieval solutions, enzymes and enzyme preparations, histological dyes and stain solutions, dewaxing and wash buffers, fluorescent dyes and fluorescent labels, assay reagents, aptamers, affinity reagents, supramolecular host-guest systems, reagents containing primary antibodies, affimers, or other affinity reagents, nucleic acid probes, non-optically detectable labels, blocking agents and inactivation agents, all for diagnostic and medical research purposes.

Abstract

A label (100, 200, 300, 400, 502, 600, 602, 700, 800) for analysing a biological sample is provided. The label (100, 200, 300, 400, 502, 600, 602, 700, 800) comprises a plurality of labelling molecules (104) and a plurality of spacer molecules (102). The label (100, 200, 300, 400, 502, 600, 602, 700, 800) further comprises at least a first nucleic acid backbone (106) and each spacer molecule (102) is attached to the first nucleic acid backbone (106). In further aspects, a marker and a method for analysing a biological sample are provided.

IPC Classes  ?

• C12Q 1/6818 - Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer

Abstract

A label for analyzing a biological sample includes a first label part comprising a first nucleic acid backbone, and a second label part comprising a second nucleic acid backbone. The first nucleic acid backbone and the second nucleic acid backbone are configured to hybridise at least partially to each other. The label further includes at least one first labelling moiety and at least one second labelling moiety, and at least one guest molecule configured to form a complex with a host molecule.

IPC Classes  ?

• C12Q 1/6818 - Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
• C12Q 1/6825 - Nucleic acid detection involving sensors
• C12Q 1/6834 - Enzymatic or biochemical coupling of nucleic acids to a solid phase

Abstract

A label for analyzing a biological sample includes a first label part comprising a first nucleic acid strand, and a second label part comprising a second nucleic acid strand. The first nucleic acid strand and the second nucleic acid strand are configured to form a duplex. The label further includes at least one first labelling moiety and at least one second labelling moiety, and at least one blocking nucleic acid strand. The at least one blocking nucleic acid strand is at least partially complementary to one of the first nucleic acid strand and the second nucleic acid strand.

IPC Classes  ?

• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• G01N 21/64 - FluorescencePhosphorescence

Abstract

A label (100, 200, 500, 702, 802, 900, 901, 1000, 1200, 1300, 1600) for analysing a biological sample is provided. The label (100, 200, 500, 702, 802, 900, 901, 1000, 1200, 1300, 1600) comprises a nucleic acid backbone (102, 502, 1002, 1102, 1202, 1301) and a first plurality of labelling moieties (104). The nucleic acid backbone (102, 502, 1002, 1102, 1202, 1301) has a duplex structure comprising at least 50% of nucleotides of the nucleic acid backbone (102, 502, 1002, 1102, 1202, 1301). In further aspects a marker (700, 800) comprising the label and a method for analysing biological samples is provided.

IPC Classes  ?

• C12Q 1/6818 - Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
• C12Q 1/6804 - Nucleic acid analysis using immunogens

Goods & Services

(1) Chemicals for use in industry and science; chemical reagents for non-medical purposes; reagents for research purposes; research reagents and preparations, except for medical or veterinary use; research preparations used in science; chemical reagents and diagnostic preparations for use in research laboratories and for use in industry; fluorescent dyes and fluorescent labels for applications in industry and science; assay reagents for use in research, quality control, diagnostic use, except for medical purposes; aptamers for use in research, quality control; affinity reagents for use in research or quality control; supramolecular host-guest systems for use in research or quality control; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for research use; kits comprising a combination of any of the aforesaid chemical reagents, research reagents and preparations, assay reagents, affinity reagents, supramolecular host-guest systems, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents and inactivation agents, all for industrial, scientific and research use. (2) Research preparations, namely antibodies or nucleic acid probes, for the investigation of disease models; preparations for medical and veterinary research; reagents containing primary antibodies for research use; chemical reagents and medical preparations for research purposes; clinical research reagents; chemical reagents for medical or veterinary research purposes, namely reagents for immuno-histochemistry detection and in situ-hybridisation detection; in situ-hybridisation probes for medical research purposes; epitope retrieval solutions for medical research purposes; enzymes and enzyme preparations for medical research purposes; histological dye and stain solutions for medical research purposes; dewaxing and wash buffers used with the aforementioned preparations; fluorescent dyes and fluorescent labels for diagnostic use; assay reagents for diagnostic use; aptamers for diagnostic use; affinity reagents for diagnostic use; supramolecular host-guest systems for diagnostic use; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for diagnostic use; kits comprising a combination of any of the aforesaid research reagents, preparations for medical and veterinary research, clinical research reagents, in situ-hybridisation probes, epitope retrieval solutions, enzymes and enzyme preparations, histological dyes and stain solutions, dewaxing and wash buffers, fluorescent dyes and fluorescent labels, assay reagents, aptamers, affinity reagents, supramolecular host-guest systems, reagents containing primary antibodies, affimers, or other affinity reagents, nucleic acid probes, non-optically detectable labels, blocking agents and inactivation agents, all for diagnostic and medical research purposes.

Goods & Services

(1) Chemicals for use in industry and science; chemical reagents for non-medical purposes; reagents for research purposes; research reagents and preparations, except for medical or veterinary use; research preparations used in science; chemical reagents and diagnostic preparations for use in research laboratories and for use in industry; fluorescent dyes and fluorescent labels for applications in industry and science; assay reagents for use in research, quality control, diagnostic use, except for medical purposes; aptamers for use in research, quality control; affinity reagents for use in research or quality control; supramolecular host-guest systems for use in research or quality control; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for research use; kits comprising a combination of any of the aforesaid chemical reagents, research reagents and preparations, assay reagents, affinity reagents, supramolecular host-guest systems, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents and inactivation agents, all for industrial, scientific and research use. (2) Research preparations, namely antibodies or nucleic acid probes, for the investigation of disease models; preparations for medical and veterinary research; reagents containing primary antibodies for research use; chemical reagents and medical preparations for research purposes; clinical research reagents; chemical reagents for medical or veterinary research purposes, namely reagents for immuno-histochemistry detection and in situ-hybridisation detection; in situ-hybridisation probes for medical research purposes; epitope retrieval solutions for medical research purposes; enzymes and enzyme preparations for medical research purposes; histological dye and stain solutions for medical research purposes; dewaxing and wash buffers used with the aforementioned preparations; fluorescent dyes and fluorescent labels for diagnostic use; assay reagents for diagnostic use; aptamers for diagnostic use; affinity reagents for diagnostic use; supramolecular host-guest systems for diagnostic use; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for diagnostic use; kits comprising a combination of any of the aforesaid research reagents, preparations for medical and veterinary research, clinical research reagents, in situ-hybridisation probes, epitope retrieval solutions, enzymes and enzyme preparations, histological dyes and stain solutions, dewaxing and wash buffers, fluorescent dyes and fluorescent labels, assay reagents, aptamers, affinity reagents, supramolecular host-guest systems, reagents containing primary antibodies, affimers, or other affinity reagents, nucleic acid probes, non-optically detectable labels, blocking agents and inactivation agents, all for diagnostic and medical research purposes.

Goods & Services

(1) Chemicals for use in industry and science; chemical reagents for non-medical purposes; research reagents and preparations, except for medical or veterinary use; research preparations used in science; chemical reagents and diagnostic preparations for use in research laboratories and for use in industry; fluorescent dyes and fluorescent labels for applications in industry and science; assay reagents for use in research, quality control, diagnostic use, excluding medical applications; aptamers for use in research, quality control; affinity reagents for use in research or quality control; supramolecular host-guest systems for use in research or quality control; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for research use; reagents for research purposes; kits comprising a combination of any of the aforesaid chemical reagents, research reagents and preparations, assay reagents, affinity reagents, supramolecular host-guest systems, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents and inactivation agents, all for industrial, scientific and research use. (2) Research preparations, namely antibodies or nucleic acid probes, for the investigation of disease models; preparations for medical and veterinary research; reagents containing primary antibodies for research use; chemical reagents and medical preparations for research purposes; clinical research reagents; chemical reagents for medical or veterinary research purposes, namely reagents for immuno-histochemistry detection and in situ-hybridisation detection; in situ-hybridisation probes for medical research purposes; epitope retrieval solutions for medical research purposes; enzymes and enzyme preparations for medical research purposes; histological dye and stain solutions for medical research purposes; dewaxing and wash buffers used with the aforementioned preparations; fluorescent dyes and fluorescent labels for diagnostic use; assay reagents for diagnostic use; aptamers for diagnostic use; affinity reagents for diagnostic use; supramolecular host-guest systems for diagnostic use; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for diagnostic use; kits comprising a combination of any of the aforesaid research reagents, preparations for medical and veterinary research, clinical research reagents, in situ-hybridisation probes, epitope retrieval solutions, enzymes and enzyme preparations, histological dyes and stain solutions, dewaxing and wash buffers, fluorescent dyes and fluorescent labels, assay reagents, aptamers, affinity reagents, supramolecular host-guest systems, reagents containing primary antibodies, affimers, or other affinity reagents, nucleic acid probes, non-optically detectable labels, blocking agents and inactivation agents, all for diagnostic and medical research purposes.

Goods & Services

Chemicals for use in industry and science; chemical reagents for non-medical purposes; research reagents and preparations, except for medical or veterinary use; research preparations used in science; chemical reagents and diagnostic preparations for use in research laboratories and for use in industry; fluorescent dyes and fluorescent labels for applications in industry and science; assay reagents for use in research, quality control, diagnostic use; aptamers for use in research, quality control; affinity reagents for use in research or quality control; supramolecular host-guest systems for use in research or quality control; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for research use; reagents for research purposes; kits comprising a combination of any of the aforesaid chemical reagents, research reagents and preparations, assay reagents, affinity reagents, supramolecular host-guest systems, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents and inactivation agents, all for industrial, scientific and research use. Research preparations, namely antibodies or nucleic acid probes, for the investigation of disease models; preparations for medical and veterinary research; reagents containing primary antibodies for research use; chemical reagents and medical preparations for research purposes; clinical research reagents; chemical reagents for medical or veterinary research purposes, namely reagents for immuno-histochemistry detection and in situ-hybridisation detection; in situ-hybridisation probes for medical research purposes; epitope retrieval solutions for medical research purposes; enzymes and enzyme preparations for medical research purposes; histological dye and stain solutions for medical research purposes; dewaxing and wash buffers used with the aforementioned preparations; fluorescent dyes and fluorescent labels for diagnostic use; assay reagents for diagnostic use; aptamers for diagnostic use; affinity reagents for diagnostic use; supramolecular host-guest systems for diagnostic use; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for diagnostic use; kits comprising a combination of any of the aforesaid research reagents, preparations for medical and veterinary research, clinical research reagents, in situ-hybridisation probes, epitope retrieval solutions, enzymes and enzyme preparations, histological dyes and stain solutions, dewaxing and wash buffers, fluorescent dyes and fluorescent labels, assay reagents, aptamers, affinity reagents, supramolecular host-guest systems, reagents containing primary antibodies, affimers, or other affinity reagents, nucleic acid probes, non-optically detectable labels, blocking agents and inactivation agents, all for diagnostic and medical research purposes.

Goods & Services

Chemicals for use in industry and science; chemical reagents for non-medical purposes; reagents for research purposes; research reagents and preparations, except for medical or veterinary use; research preparations used in science; chemical reagents and diagnostic preparations for use in research laboratories and for use in industry; fluorescent dyes and fluorescent labels for applications in industry and science; assay reagents for use in research, quality control, diagnostic use; aptamers for use in research, quality control; affinity reagents for use in research or quality control; supramolecular host-guest systems for use in research or quality control; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for research use; kits comprising a combination of any of the aforesaid chemical reagents, research reagents and preparations, assay reagents, affinity reagents, supramolecular host-guest systems, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents and inactivation agents, all for industrial, scientific and research use. Research preparations, namely antibodies or nucleic acid probes, for the investigation of disease models; preparations for medical and veterinary research; reagents containing primary antibodies for research use; chemical reagents and medical preparations for research purposes; clinical research reagents; chemical reagents for medical or veterinary research purposes, namely reagents for immuno-histochemistry detection and in situ-hybridisation detection; in situ-hybridisation probes for medical research purposes; epitope retrieval solutions for medical research purposes; enzymes and enzyme preparations for medical research purposes; histological dye and stain solutions for medical research purposes; dewaxing and wash buffers used with the aforementioned preparations; fluorescent dyes and fluorescent labels for diagnostic use; assay reagents for diagnostic use; aptamers for diagnostic use; affinity reagents for diagnostic use; supramolecular host-guest systems for diagnostic use; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for diagnostic use; kits comprising a combination of any of the aforesaid research reagents, preparations for medical and veterinary research, clinical research reagents, in situ-hybridisation probes, epitope retrieval solutions, enzymes and enzyme preparations, histological dyes and stain solutions, dewaxing and wash buffers, fluorescent dyes and fluorescent labels, assay reagents, aptamers, affinity reagents, supramolecular host-guest systems, reagents containing primary antibodies, affimers, or other affinity reagents, nucleic acid probes, non-optically detectable labels, blocking agents and inactivation agents, all for diagnostic and medical research purposes.

Goods & Services

Chemicals for use in industry and science; chemical reagents for non-medical purposes; reagents for research purposes; research reagents and preparations, except for medical or veterinary use; research preparations used in science; chemical reagents and diagnostic preparations for use in research laboratories and for use in industry; fluorescent dyes and fluorescent labels for applications in industry and science; assay reagents for use in research, quality control, diagnostic use; aptamers for use in research, quality control; affinity reagents for use in research or quality control; supramolecular host-guest systems for use in research or quality control; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for research use; kits comprising a combination of any of the aforesaid chemical reagents, research reagents and preparations, assay reagents, affinity reagents, supramolecular host-guest systems, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents and inactivation agents, all for industrial, scientific and research use. Research preparations, namely antibodies or nucleic acid probes, for the investigation of disease models; preparations for medical and veterinary research; reagents containing primary antibodies for research use; chemical reagents and medical preparations for research purposes; clinical research reagents; chemical reagents for medical or veterinary research purposes, namely reagents for immuno-histochemistry detection and in situ-hybridisation detection; in situ-hybridisation probes for medical research purposes; epitope retrieval solutions for medical research purposes; enzymes and enzyme preparations for medical research purposes; histological dye and stain solutions for medical research purposes; dewaxing and wash buffers used with the aforementioned preparations; fluorescent dyes and fluorescent labels for diagnostic use; assay reagents for diagnostic use; aptamers for diagnostic use; affinity reagents for diagnostic use; supramolecular host-guest systems for diagnostic use; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for diagnostic use; kits comprising a combination of any of the aforesaid research reagents, preparations for medical and veterinary research, clinical research reagents, in situ-hybridisation probes, epitope retrieval solutions, enzymes and enzyme preparations, histological dyes and stain solutions, dewaxing and wash buffers, fluorescent dyes and fluorescent labels, assay reagents, aptamers, affinity reagents, supramolecular host-guest systems, reagents containing primary antibodies, affimers, or other affinity reagents, nucleic acid probes, non-optically detectable labels, blocking agents and inactivation agents, all for diagnostic and medical research purposes.

Goods & Services

(1) Chemicals for use in industry and science; chemical reagents for non-medical purposes; reagents for research purposes; research reagents and preparations, except for medical or veterinary use; research preparations used in science; chemical reagents and diagnostic preparations for use in research laboratories and for use in industry; fluorescent dyes and fluorescent labels for applications in industry and science; assay reagents for use in research, quality control, diagnostic use, except for medical purposes; aptamers for use in research, quality control; affinity reagents for use in research or quality control; supramolecular host-guest systems for use in research or quality control; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for research use; kits comprising a combination of any of the aforesaid chemical reagents, research reagents and preparations, assay reagents, affinity reagents, supramolecular host-guest systems, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents and inactivation agents, all for industrial, scientific and research use. (2) Research preparations, namely antibodies or nucleic acid probes, for the investigation of disease models; preparations for medical and veterinary research; reagents containing primary antibodies for research use; chemical reagents and medical preparations for research purposes; clinical research reagents; chemical reagents for medical or veterinary research purposes, namely reagents for immuno-histochemistry detection and in situ-hybridisation detection; in situ-hybridisation probes for medical research purposes; epitope retrieval solutions for medical research purposes; enzymes and enzyme preparations for medical research purposes; histological dye and stain solutions for medical research purposes; dewaxing and wash buffers used with the aforementioned preparations; fluorescent dyes and fluorescent labels for diagnostic use; assay reagents for diagnostic use; aptamers for diagnostic use; affinity reagents for diagnostic use; supramolecular host-guest systems for diagnostic use; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for diagnostic use; kits comprising a combination of any of the aforesaid research reagents, preparations for medical and veterinary research, clinical research reagents, in situ-hybridisation probes, epitope retrieval solutions, enzymes and enzyme preparations, histological dyes and stain solutions, dewaxing and wash buffers, fluorescent dyes and fluorescent labels, assay reagents, aptamers, affinity reagents, supramolecular host-guest systems, reagents containing primary antibodies, affimers, or other affinity reagents, nucleic acid probes, non-optically detectable labels, blocking agents and inactivation agents, all for diagnostic and medical research purposes.

Goods & Services

(1) Chemicals for use in industry and science; chemical reagents for non-medical purposes; reagents for research purposes; research reagents and preparations, except for medical or veterinary use; research preparations used in science; chemical reagents and diagnostic preparations for use in research laboratories and for use in industry; fluorescent dyes and fluorescent labels for applications in industry and science; assay reagents for use in research, quality control, diagnostic use, except for medical purposes; aptamers for use in research, quality control; affinity reagents for use in research or quality control; supramolecular host-guest systems for use in research or quality control; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for research use; kits comprising a combination of any of the aforesaid chemical reagents, research reagents and preparations, assay reagents, affinity reagents, supramolecular host-guest systems, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents and inactivation agents, all for industrial, scientific and research use. (2) Research preparations, namely antibodies or nucleic acid probes, for the investigation of disease models; preparations for medical and veterinary research; reagents containing primary antibodies for research use; chemical reagents and medical preparations for research purposes; clinical research reagents; chemical reagents for medical or veterinary research purposes, namely reagents for immuno-histochemistry detection and in situ-hybridisation detection; in situ-hybridisation probes for medical research purposes; epitope retrieval solutions for medical research purposes; enzymes and enzyme preparations for medical research purposes; histological dye and stain solutions for medical research purposes; dewaxing and wash buffers used with the aforementioned preparations; fluorescent dyes and fluorescent labels for diagnostic use; assay reagents for diagnostic use; aptamers for diagnostic use; affinity reagents for diagnostic use; supramolecular host-guest systems for diagnostic use; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for diagnostic use; kits comprising a combination of any of the aforesaid research reagents, preparations for medical and veterinary research, clinical research reagents, in situ-hybridisation probes, epitope retrieval solutions, enzymes and enzyme preparations, histological dyes and stain solutions, dewaxing and wash buffers, fluorescent dyes and fluorescent labels, assay reagents, aptamers, affinity reagents, supramolecular host-guest systems, reagents containing primary antibodies, affimers, or other affinity reagents, nucleic acid probes, non-optically detectable labels, blocking agents and inactivation agents, all for diagnostic and medical research purposes.

Goods & Services

Chemicals for use in industry and science; chemical reagents for non-medical purposes; reagents for research purposes; research reagents and preparations, except for medical or veterinary use; research preparations used in science; chemical reagents and diagnostic preparations for use in research laboratories and for use in industry; fluorescent dyes and fluorescent labels for applications in industry and science; assay reagents for use in research, quality control, diagnostic use; aptamers for use in research, quality control; affinity reagents for use in research or quality control; supramolecular host-guest systems for use in research or quality control; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for research use; kits comprising a combination of any of the aforesaid chemical reagents, research reagents and preparations, assay reagents, affinity reagents, supramolecular host-guest systems, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents and inactivation agents, all for industrial, scientific and research use. Research preparations, namely antibodies or nucleic acid probes, for the investigation of disease models; preparations for medical and veterinary research; reagents containing primary antibodies for research use; chemical reagents and medical preparations for research purposes; clinical research reagents; chemical reagents for medical or veterinary research purposes, namely reagents for immuno-histochemistry detection and in situ-hybridisation detection; in situ-hybridisation probes for medical research purposes; epitope retrieval solutions for medical research purposes; enzymes and enzyme preparations for medical research purposes; histological dye and stain solutions for medical research purposes; dewaxing and wash buffers used with the aforementioned preparations; fluorescent dyes and fluorescent labels for diagnostic use; assay reagents for diagnostic use; aptamers for diagnostic use; affinity reagents for diagnostic use; supramolecular host-guest systems for diagnostic use; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for diagnostic use; kits comprising a combination of any of the aforesaid research reagents, preparations for medical and veterinary research, clinical research reagents, in situ-hybridisation probes, epitope retrieval solutions, enzymes and enzyme preparations, histological dyes and stain solutions, dewaxing and wash buffers, fluorescent dyes and fluorescent labels, assay reagents, aptamers, affinity reagents, supramolecular host-guest systems, reagents containing primary antibodies, affimers, or other affinity reagents, nucleic acid probes, non-optically detectable labels, blocking agents and inactivation agents, all for diagnostic and medical research purposes.

Goods & Services

Chemicals for use in industry and science; chemical reagents for non-medical purposes; reagents for research purposes; research reagents and preparations, except for medical or veterinary use; research preparations used in science; chemical reagents and diagnostic preparations for use in research laboratories and for use in industry; fluorescent dyes and fluorescent labels for applications in industry and science; assay reagents for use in research, quality control, diagnostic use; aptamers for use in research, quality control; affinity reagents for use in research or quality control; supramolecular host-guest systems for use in research or quality control; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for research use; kits comprising a combination of any of the aforesaid chemical reagents, research reagents and preparations, assay reagents, affinity reagents, supramolecular host-guest systems, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents and inactivation agents, all for industrial, scientific and research use. Research preparations, namely antibodies or nucleic acid probes, for the investigation of disease models; preparations for medical and veterinary research; reagents containing primary antibodies for research use; chemical reagents and medical preparations for research purposes; clinical research reagents; chemical reagents for medical or veterinary research purposes, namely reagents for immuno-histochemistry detection and in situ-hybridisation detection; in situ-hybridisation probes for medical research purposes; epitope retrieval solutions for medical research purposes; enzymes and enzyme preparations for medical research purposes; histological dye and stain solutions for medical research purposes; dewaxing and wash buffers used with the aforementioned preparations; fluorescent dyes and fluorescent labels for diagnostic use; assay reagents for diagnostic use; aptamers for diagnostic use; affinity reagents for diagnostic use; supramolecular host-guest systems for diagnostic use; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for diagnostic use; kits comprising a combination of any of the aforesaid research reagents, preparations for medical and veterinary research, clinical research reagents, in situ-hybridisation probes, epitope retrieval solutions, enzymes and enzyme preparations, histological dyes and stain solutions, dewaxing and wash buffers, fluorescent dyes and fluorescent labels, assay reagents, aptamers, affinity reagents, supramolecular host-guest systems, reagents containing primary antibodies, affimers, or other affinity reagents, nucleic acid probes, non-optically detectable labels, blocking agents and inactivation agents, all for diagnostic and medical research purposes.

Abstract

The invention relates to compounds of the general formulae (I)-(IV), which are characterized by substituents B comprising one or more sulfonic acid groups and their use as marker groups for the detection of analytes.

IPC Classes  ?

• C09B 1/34 - Dyes with amino groups substituted by hydrocarbon radicals substituted by aryl groups sulfonated
• C07D 311/88 - Nitrogen atoms
• C07C 301/00 - Esters of sulfurous acid
• C07C 309/31 - Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups by alkyl groups containing at least three carbon atoms
• C07C 323/62 - Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
• C07D 405/10 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
• C07D 471/04 - Ortho-condensed systems
• C07C 13/00 - Cyclic hydrocarbons containing rings other than, or in addition to, six-membered aromatic rings
• C07F 7/08 - Compounds having one or more C—Si linkages
• C07D 215/10 - Quaternary compounds
• C09B 5/42 - Pyridino anthraquinones
• C09B 57/02 - Coumarine dyes
• G01N 21/64 - FluorescencePhosphorescence

Goods & Services

Chemicals used in industry, science and photography, as well as in agriculture, horticulture and forestry. Pharmaceutical products except therapeutics for dermatology and oncology. Scientific instruments.

Goods & Services

Chemicals used in industry, science and photography, as well as in agriculture, horticulture and forestry. Pharmaceutical products except therapeutics for dermatology and oncology. Scientific instruments.

Abstract

7 on the central carbon atom of the chromophore, to processes for their preparation, and to the use thereof for the determination of analytes.

IPC Classes  ?

• G01N 21/64 - FluorescencePhosphorescence
• C09B 11/28 - Pyronines
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances

Abstract

The invention relates to polycyclic compounds of general formula (I) which are characterized by an amine substituent NR6R7 at the central carbon atom of the chromophore, to methods for producing said polycyclic compounds, and to the use of said polycyclic compounds to identify analytes.

IPC Classes  ?

• C09B 11/28 - Pyronines
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances