Abrégé

The present invention relates to dyes with pH-dependent absorption and fluorescence for pH detection and their applications in biology, medicine and theranostic. In particular, the present invention relates to compounds of the general formulae (I)-(IV), that show pH dependent absorption and fluorescence spectra as well as pH dependent fluorescence quantum yield, methods for their preparation and their application as pH-sensors and labeling groups for the detection of analytes.

Classes IPC  ?

• C09B 1/00 - Colorants à noyau anthracène non condensé avec d'autres cycles
• C09B 3/82 - Préparation à partir de substances contenant déjà le noyau anthracène condensé
• C09B 15/00 - Colorants acridiniques

Produits et services

Chemicals for use in industry and science; chemical reagents for non-medical purposes; reagents for research purposes; research reagents and preparations, except for medical or veterinary use; research preparations used in science; chemical reagents and diagnostic preparations for use in research laboratories and for use in industry; fluorescent dyes and fluorescent labels for applications in industry and science; assay reagents for use in research, quality control, diagnostic use; aptamers for use in research, quality control; affinity reagents for use in research or quality control; supramolecular host-guest systems for use in research or quality control; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for research use; kits comprising a combination of any of the aforesaid chemical reagents, research reagents and preparations, assay reagents, affinity reagents, supramolecular host-guest systems, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents and inactivation agents, all for industrial, scientific and research use. Research preparations, namely antibodies or nucleic acid probes, for the investigation of disease models; preparations for medical and veterinary research; reagents containing primary antibodies for research use; chemical reagents and medical preparations for research purposes; clinical research reagents; chemical reagents for medical or veterinary research purposes, namely reagents for immuno-histochemistry detection and in situ-hybridisation detection; in situ-hybridisation probes for medical research purposes; epitope retrieval solutions for medical research purposes; enzymes and enzyme preparations for medical research purposes; histological dye and stain solutions for medical research purposes; dewaxing and wash buffers used with the aforementioned preparations; fluorescent dyes and fluorescent labels for diagnostic use; assay reagents for diagnostic use; aptamers for diagnostic use; affinity reagents for diagnostic use; supramolecular host-guest systems for diagnostic use; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for diagnostic use; kits comprising a combination of any of the aforesaid research reagents, preparations for medical and veterinary research, clinical research reagents, in situ-hybridisation probes, epitope retrieval solutions, enzymes and enzyme preparations, histological dyes and stain solutions, dewaxing and wash buffers, fluorescent dyes and fluorescent labels, assay reagents, aptamers, affinity reagents, supramolecular host-guest systems, reagents containing primary antibodies, affimers, or other affinity reagents, nucleic acid probes, non-optically detectable labels, blocking agents and inactivation agents, all for diagnostic and medical research purposes.

Produits et services

Chemicals for use in industry and science; chemical reagents for non-medical purposes; reagents for research purposes; research reagents and preparations, except for medical or veterinary use; research preparations used in science; chemical reagents and diagnostic preparations for use in research laboratories and for use in industry; fluorescent dyes and fluorescent labels for applications in industry and science; assay reagents for use in research, quality control, diagnostic use; aptamers for use in research, quality control; affinity reagents for use in research or quality control; supramolecular host-guest systems for use in research or quality control; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for research use; kits comprising a combination of any of the aforesaid chemical reagents, research reagents and preparations, assay reagents, affinity reagents, supramolecular host-guest systems, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents and inactivation agents, all for industrial, scientific and research use. Research preparations, namely antibodies or nucleic acid probes, for the investigation of disease models; preparations for medical and veterinary research; reagents containing primary antibodies for research use; chemical reagents and medical preparations for research purposes; clinical research reagents; chemical reagents for medical or veterinary research purposes, namely reagents for immuno-histochemistry detection and in situ-hybridisation detection; in situ-hybridisation probes for medical research purposes; epitope retrieval solutions for medical research purposes; enzymes and enzyme preparations for medical research purposes; histological dye and stain solutions for medical research purposes; dewaxing and wash buffers used with the aforementioned preparations; fluorescent dyes and fluorescent labels for diagnostic use; assay reagents for diagnostic use; aptamers for diagnostic use; affinity reagents for diagnostic use; supramolecular host-guest systems for diagnostic use; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for diagnostic use; kits comprising a combination of any of the aforesaid research reagents, preparations for medical and veterinary research, clinical research reagents, in situ-hybridisation probes, epitope retrieval solutions, enzymes and enzyme preparations, histological dyes and stain solutions, dewaxing and wash buffers, fluorescent dyes and fluorescent labels, assay reagents, aptamers, affinity reagents, supramolecular host-guest systems, reagents containing primary antibodies, affimers, or other affinity reagents, nucleic acid probes, non-optically detectable labels, blocking agents and inactivation agents, all for diagnostic and medical research purposes.

Produits et services

Chemicals for use in industry and science; chemical reagents for non-medical purposes; research reagents and preparations, except for medical or veterinary use; research preparations used in science; chemical reagents and diagnostic preparations for use in research laboratories and for use in industry; fluorescent dyes and fluorescent labels for applications in industry and science; assay reagents for use in research, quality control, diagnostic use; aptamers for use in research, quality control; affinity reagents for use in research or quality control; supramolecular host-guest systems for use in research or quality control; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for research use; reagents for research purposes; kits comprising a combination of any of the aforesaid chemical reagents, research reagents and preparations, assay reagents, affinity reagents, supramolecular host-guest systems, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents and inactivation agents, all for industrial, scientific and research use. Research preparations, namely antibodies or nucleic acid probes, for the investigation of disease models; preparations for medical and veterinary research; reagents containing primary antibodies for research use; chemical reagents and medical preparations for research purposes; clinical research reagents; chemical reagents for medical or veterinary research purposes, namely reagents for immuno-histochemistry detection and in situ-hybridisation detection; in situ-hybridisation probes for medical research purposes; epitope retrieval solutions for medical research purposes; enzymes and enzyme preparations for medical research purposes; histological dye and stain solutions for medical research purposes; dewaxing and wash buffers used with the aforementioned preparations; fluorescent dyes and fluorescent labels for diagnostic use; assay reagents for diagnostic use; aptamers for diagnostic use; affinity reagents for diagnostic use; supramolecular host-guest systems for diagnostic use; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for diagnostic use; kits comprising a combination of any of the aforesaid research reagents, preparations for medical and veterinary research, clinical research reagents, in situ-hybridisation probes, epitope retrieval solutions, enzymes and enzyme preparations, histological dyes and stain solutions, dewaxing and wash buffers, fluorescent dyes and fluorescent labels, assay reagents, aptamers, affinity reagents, supramolecular host-guest systems, reagents containing primary antibodies, affimers, or other affinity reagents, nucleic acid probes, non-optically detectable labels, blocking agents and inactivation agents, all for diagnostic and medical research purposes.

Produits et services

Chemicals for use in industry and science; chemical reagents for non-medical purposes; reagents for research purposes; research reagents and preparations, except for medical or veterinary use; research preparations used in science; chemical reagents and diagnostic preparations for use in research laboratories and for use in industry; fluorescent dyes and fluorescent labels for applications in industry and science; assay reagents for use in research, quality control, diagnostic use; aptamers for use in research, quality control; affinity reagents for use in research or quality control; supramolecular host-guest systems for use in research or quality control; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for research use; kits comprising a combination of any of the aforesaid chemical reagents, research reagents and preparations, assay reagents, affinity reagents, supramolecular host-guest systems, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents and inactivation agents, all for industrial, scientific and research use. Research preparations, namely antibodies or nucleic acid probes, for the investigation of disease models; preparations for medical and veterinary research; reagents containing primary antibodies for research use; chemical reagents and medical preparations for research purposes; clinical research reagents; chemical reagents for medical or veterinary research purposes, namely reagents for immuno-histochemistry detection and in situ-hybridisation detection; in situ-hybridisation probes for medical research purposes; epitope retrieval solutions for medical research purposes; enzymes and enzyme preparations for medical research purposes; histological dye and stain solutions for medical research purposes; dewaxing and wash buffers used with the aforementioned preparations; fluorescent dyes and fluorescent labels for diagnostic use; assay reagents for diagnostic use; aptamers for diagnostic use; affinity reagents for diagnostic use; supramolecular host-guest systems for diagnostic use; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for diagnostic use; kits comprising a combination of any of the aforesaid research reagents, preparations for medical and veterinary research, clinical research reagents, in situ-hybridisation probes, epitope retrieval solutions, enzymes and enzyme preparations, histological dyes and stain solutions, dewaxing and wash buffers, fluorescent dyes and fluorescent labels, assay reagents, aptamers, affinity reagents, supramolecular host-guest systems, reagents containing primary antibodies, affimers, or other affinity reagents, nucleic acid probes, non-optically detectable labels, blocking agents and inactivation agents, all for diagnostic and medical research purposes.

Produits et services

Chemicals for use in industry and science; chemical reagents for non-medical purposes; reagents for research purposes; research reagents and preparations, except for medical or veterinary use; research preparations used in science; chemical reagents and diagnostic preparations for use in research laboratories and for use in industry; fluorescent dyes and fluorescent labels for applications in industry and science; assay reagents for use in research, quality control, diagnostic use; aptamers for use in research, quality control; affinity reagents for use in research or quality control; supramolecular host-guest systems for use in research or quality control; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for research use; kits comprising a combination of any of the aforesaid chemical reagents, research reagents and preparations, assay reagents, affinity reagents, supramolecular host-guest systems, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents and inactivation agents, all for industrial, scientific and research use. Research preparations, namely antibodies or nucleic acid probes, for the investigation of disease models; preparations for medical and veterinary research; reagents containing primary antibodies for research use; chemical reagents and medical preparations for research purposes; clinical research reagents; chemical reagents for medical or veterinary research purposes, namely reagents for immuno-histochemistry detection and in situ-hybridisation detection; in situ-hybridisation probes for medical research purposes; epitope retrieval solutions for medical research purposes; enzymes and enzyme preparations for medical research purposes; histological dye and stain solutions for medical research purposes; dewaxing and wash buffers used with the aforementioned preparations; fluorescent dyes and fluorescent labels for diagnostic use; assay reagents for diagnostic use; aptamers for diagnostic use; affinity reagents for diagnostic use; supramolecular host-guest systems for diagnostic use; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for diagnostic use; kits comprising a combination of any of the aforesaid research reagents, preparations for medical and veterinary research, clinical research reagents, in situ-hybridisation probes, epitope retrieval solutions, enzymes and enzyme preparations, histological dyes and stain solutions, dewaxing and wash buffers, fluorescent dyes and fluorescent labels, assay reagents, aptamers, affinity reagents, supramolecular host-guest systems, reagents containing primary antibodies, affimers, or other affinity reagents, nucleic acid probes, non-optically detectable labels, blocking agents and inactivation agents, all for diagnostic and medical research purposes.

Abrégé

A label (100, 200, 300, 400, 502, 600, 602, 700, 800) for analysing a biological sample is provided. The label (100, 200, 300, 400, 502, 600, 602, 700, 800) comprises a plurality of labelling molecules (104) and a plurality of spacer molecules (102). The label (100, 200, 300, 400, 502, 600, 602, 700, 800) further comprises at least a first nucleic acid backbone (106) and each spacer molecule (102) is attached to the first nucleic acid backbone (106). In further aspects, a marker and a method for analysing a biological sample are provided.

Classes IPC  ?

• C12Q 1/6818 - Tests d’hybridation caractérisés par les moyens de détection impliquant l’interaction de plusieurs marqueurs, p. ex. transfert d’énergie de résonance

Abrégé

A label for analyzing a biological sample includes a first label part comprising a first nucleic acid backbone, and a second label part comprising a second nucleic acid backbone. The first nucleic acid backbone and the second nucleic acid backbone are configured to hybridise at least partially to each other. The label further includes at least one first labelling moiety and at least one second labelling moiety, and at least one guest molecule configured to form a complex with a host molecule.

Classes IPC  ?

• C12Q 1/6818 - Tests d’hybridation caractérisés par les moyens de détection impliquant l’interaction de plusieurs marqueurs, p. ex. transfert d’énergie de résonance
• C12Q 1/6825 - Détecteurs faisant intervenir la détection d’acides nucléiques
• C12Q 1/6834 - Couplage enzymatique ou biochimique d’acides nucléiques à une phase solide

Abrégé

A label for analyzing a biological sample includes a first label part comprising a first nucleic acid strand, and a second label part comprising a second nucleic acid strand. The first nucleic acid strand and the second nucleic acid strand are configured to form a duplex. The label further includes at least one first labelling moiety and at least one second labelling moiety, and at least one blocking nucleic acid strand. The at least one blocking nucleic acid strand is at least partially complementary to one of the first nucleic acid strand and the second nucleic acid strand.

Classes IPC  ?

• G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
• G01N 21/64 - FluorescencePhosphorescence

Abrégé

A label (100, 200, 500, 702, 802, 900, 901, 1000, 1200, 1300, 1600) for analysing a biological sample is provided. The label (100, 200, 500, 702, 802, 900, 901, 1000, 1200, 1300, 1600) comprises a nucleic acid backbone (102, 502, 1002, 1102, 1202, 1301) and a first plurality of labelling moieties (104). The nucleic acid backbone (102, 502, 1002, 1102, 1202, 1301) has a duplex structure comprising at least 50% of nucleotides of the nucleic acid backbone (102, 502, 1002, 1102, 1202, 1301). In further aspects a marker (700, 800) comprising the label and a method for analysing biological samples is provided.

Classes IPC  ?

• C12Q 1/6818 - Tests d’hybridation caractérisés par les moyens de détection impliquant l’interaction de plusieurs marqueurs, p. ex. transfert d’énergie de résonance
• C12Q 1/6804 - Analyse d’acides nucléiques utilisant des immunogènes

Produits et services

(1) Chemicals for use in industry and science; chemical reagents for non-medical purposes; reagents for research purposes; research reagents and preparations, except for medical or veterinary use; research preparations used in science; chemical reagents and diagnostic preparations for use in research laboratories and for use in industry; fluorescent dyes and fluorescent labels for applications in industry and science; assay reagents for use in research, quality control, diagnostic use; aptamers for use in research, quality control; affinity reagents for use in research or quality control; supramolecular host-guest systems for use in research or quality control; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for research use; kits comprising a combination of any of the aforesaid chemical reagents, research reagents and preparations, assay reagents, affinity reagents, supramolecular host-guest systems, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents and inactivation agents, all for industrial, scientific and research use. (2) Research preparations, namely antibodies or nucleic acid probes, for the investigation of disease models; preparations for medical and veterinary research; reagents containing primary antibodies for research use; chemical reagents and medical preparations for research purposes; clinical research reagents; chemical reagents for medical or veterinary research purposes, namely reagents for immuno-histochemistry detection and in situ-hybridisation detection; in situ-hybridisation probes for medical research purposes; epitope retrieval solutions for medical research purposes; enzymes and enzyme preparations for medical research purposes; histological dye and stain solutions for medical research purposes; dewaxing and wash buffers used with the aforementioned preparations; fluorescent dyes and fluorescent labels for diagnostic use; assay reagents for diagnostic use; aptamers for diagnostic use; affinity reagents for diagnostic use; supramolecular host-guest systems for diagnostic use; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for diagnostic use; kits comprising a combination of any of the aforesaid research reagents, preparations for medical and veterinary research, clinical research reagents, in situ-hybridisation probes, epitope retrieval solutions, enzymes and enzyme preparations, histological dyes and stain solutions, dewaxing and wash buffers, fluorescent dyes and fluorescent labels, assay reagents, aptamers, affinity reagents, supramolecular host-guest systems, reagents containing primary antibodies, affimers, or other affinity reagents, nucleic acid probes, non-optically detectable labels, blocking agents and inactivation agents, all for diagnostic and medical research purposes.

Produits et services

(1) Chemicals for use in industry and science; chemical reagents for non-medical purposes; reagents for research purposes; research reagents and preparations, except for medical or veterinary use; research preparations used in science; chemical reagents and diagnostic preparations for use in research laboratories and for use in industry; fluorescent dyes and fluorescent labels for applications in industry and science; assay reagents for use in research, quality control, diagnostic use; aptamers for use in research, quality control; affinity reagents for use in research or quality control; supramolecular host-guest systems for use in research or quality control; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for research use; kits comprising a combination of any of the aforesaid chemical reagents, research reagents and preparations, assay reagents, affinity reagents, supramolecular host-guest systems, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents and inactivation agents, all for industrial, scientific and research use. (2) Research preparations, namely antibodies or nucleic acid probes, for the investigation of disease models; preparations for medical and veterinary research; reagents containing primary antibodies for research use; chemical reagents and medical preparations for research purposes; clinical research reagents; chemical reagents for medical or veterinary research purposes, namely reagents for immuno-histochemistry detection and in situ-hybridisation detection; in situ-hybridisation probes for medical research purposes; epitope retrieval solutions for medical research purposes; enzymes and enzyme preparations for medical research purposes; histological dye and stain solutions for medical research purposes; dewaxing and wash buffers used with the aforementioned preparations; fluorescent dyes and fluorescent labels for diagnostic use; assay reagents for diagnostic use; aptamers for diagnostic use; affinity reagents for diagnostic use; supramolecular host-guest systems for diagnostic use; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for diagnostic use; kits comprising a combination of any of the aforesaid research reagents, preparations for medical and veterinary research, clinical research reagents, in situ-hybridisation probes, epitope retrieval solutions, enzymes and enzyme preparations, histological dyes and stain solutions, dewaxing and wash buffers, fluorescent dyes and fluorescent labels, assay reagents, aptamers, affinity reagents, supramolecular host-guest systems, reagents containing primary antibodies, affimers, or other affinity reagents, nucleic acid probes, non-optically detectable labels, blocking agents and inactivation agents, all for diagnostic and medical research purposes.

Produits et services

(1) Chemicals for use in industry and science; chemical reagents for non-medical purposes; research reagents and preparations, except for medical or veterinary use; research preparations used in science; chemical reagents and diagnostic preparations for use in research laboratories and for use in industry; fluorescent dyes and fluorescent labels for applications in industry and science; assay reagents for use in research, quality control, diagnostic use; aptamers for use in research, quality control; affinity reagents for use in research or quality control; supramolecular host-guest systems for use in research or quality control; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for research use; reagents for research purposes; kits comprising a combination of any of the aforesaid chemical reagents, research reagents and preparations, assay reagents, affinity reagents, supramolecular host-guest systems, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents and inactivation agents, all for industrial, scientific and research use. (2) Research preparations, namely antibodies or nucleic acid probes, for the investigation of disease models; preparations for medical and veterinary research; reagents containing primary antibodies for research use; chemical reagents and medical preparations for research purposes; clinical research reagents; chemical reagents for medical or veterinary research purposes, namely reagents for immuno-histochemistry detection and in situ-hybridisation detection; in situ-hybridisation probes for medical research purposes; epitope retrieval solutions for medical research purposes; enzymes and enzyme preparations for medical research purposes; histological dye and stain solutions for medical research purposes; dewaxing and wash buffers used with the aforementioned preparations; fluorescent dyes and fluorescent labels for diagnostic use; assay reagents for diagnostic use; aptamers for diagnostic use; affinity reagents for diagnostic use; supramolecular host-guest systems for diagnostic use; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for diagnostic use; kits comprising a combination of any of the aforesaid research reagents, preparations for medical and veterinary research, clinical research reagents, in situ-hybridisation probes, epitope retrieval solutions, enzymes and enzyme preparations, histological dyes and stain solutions, dewaxing and wash buffers, fluorescent dyes and fluorescent labels, assay reagents, aptamers, affinity reagents, supramolecular host-guest systems, reagents containing primary antibodies, affimers, or other affinity reagents, nucleic acid probes, non-optically detectable labels, blocking agents and inactivation agents, all for diagnostic and medical research purposes.

Produits et services

Chemicals for use in industry and science; chemical reagents for non-medical purposes; research reagents and preparations, except for medical or veterinary use; research preparations used in science; chemical reagents and diagnostic preparations for use in research laboratories and for use in industry; fluorescent dyes and fluorescent labels for applications in industry and science; assay reagents for use in research, quality control, diagnostic use; aptamers for use in research, quality control; affinity reagents for use in research or quality control; supramolecular host-guest systems for use in research or quality control; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for research use; reagents for research purposes; kits comprising a combination of any of the aforesaid chemical reagents, research reagents and preparations, assay reagents, affinity reagents, supramolecular host-guest systems, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents and inactivation agents, all for industrial, scientific and research use. Research preparations, namely antibodies or nucleic acid probes, for the investigation of disease models; preparations for medical and veterinary research; reagents containing primary antibodies for research use; chemical reagents and medical preparations for research purposes; clinical research reagents; chemical reagents for medical or veterinary research purposes, namely reagents for immuno-histochemistry detection and in situ-hybridisation detection; in situ-hybridisation probes for medical research purposes; epitope retrieval solutions for medical research purposes; enzymes and enzyme preparations for medical research purposes; histological dye and stain solutions for medical research purposes; dewaxing and wash buffers used with the aforementioned preparations; fluorescent dyes and fluorescent labels for diagnostic use; assay reagents for diagnostic use; aptamers for diagnostic use; affinity reagents for diagnostic use; supramolecular host-guest systems for diagnostic use; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for diagnostic use; kits comprising a combination of any of the aforesaid research reagents, preparations for medical and veterinary research, clinical research reagents, in situ-hybridisation probes, epitope retrieval solutions, enzymes and enzyme preparations, histological dyes and stain solutions, dewaxing and wash buffers, fluorescent dyes and fluorescent labels, assay reagents, aptamers, affinity reagents, supramolecular host-guest systems, reagents containing primary antibodies, affimers, or other affinity reagents, nucleic acid probes, non-optically detectable labels, blocking agents and inactivation agents, all for diagnostic and medical research purposes.

Produits et services

Chemicals for use in industry and science; chemical reagents for non-medical purposes; reagents for research purposes; research reagents and preparations, except for medical or veterinary use; research preparations used in science; chemical reagents and diagnostic preparations for use in research laboratories and for use in industry; fluorescent dyes and fluorescent labels for applications in industry and science; assay reagents for use in research, quality control, diagnostic use; aptamers for use in research, quality control; affinity reagents for use in research or quality control; supramolecular host-guest systems for use in research or quality control; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for research use; kits comprising a combination of any of the aforesaid chemical reagents, research reagents and preparations, assay reagents, affinity reagents, supramolecular host-guest systems, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents and inactivation agents, all for industrial, scientific and research use. Research preparations, namely antibodies or nucleic acid probes, for the investigation of disease models; preparations for medical and veterinary research; reagents containing primary antibodies for research use; chemical reagents and medical preparations for research purposes; clinical research reagents; chemical reagents for medical or veterinary research purposes, namely reagents for immuno-histochemistry detection and in situ-hybridisation detection; in situ-hybridisation probes for medical research purposes; epitope retrieval solutions for medical research purposes; enzymes and enzyme preparations for medical research purposes; histological dye and stain solutions for medical research purposes; dewaxing and wash buffers used with the aforementioned preparations; fluorescent dyes and fluorescent labels for diagnostic use; assay reagents for diagnostic use; aptamers for diagnostic use; affinity reagents for diagnostic use; supramolecular host-guest systems for diagnostic use; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for diagnostic use; kits comprising a combination of any of the aforesaid research reagents, preparations for medical and veterinary research, clinical research reagents, in situ-hybridisation probes, epitope retrieval solutions, enzymes and enzyme preparations, histological dyes and stain solutions, dewaxing and wash buffers, fluorescent dyes and fluorescent labels, assay reagents, aptamers, affinity reagents, supramolecular host-guest systems, reagents containing primary antibodies, affimers, or other affinity reagents, nucleic acid probes, non-optically detectable labels, blocking agents and inactivation agents, all for diagnostic and medical research purposes.

Produits et services

Chemicals for use in industry and science; chemical reagents for non-medical purposes; reagents for research purposes; research reagents and preparations, except for medical or veterinary use; research preparations used in science; chemical reagents and diagnostic preparations for use in research laboratories and for use in industry; fluorescent dyes and fluorescent labels for applications in industry and science; assay reagents for use in research, quality control, diagnostic use; aptamers for use in research, quality control; affinity reagents for use in research or quality control; supramolecular host-guest systems for use in research or quality control; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for research use; kits comprising a combination of any of the aforesaid chemical reagents, research reagents and preparations, assay reagents, affinity reagents, supramolecular host-guest systems, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents and inactivation agents, all for industrial, scientific and research use. Research preparations, namely antibodies or nucleic acid probes, for the investigation of disease models; preparations for medical and veterinary research; reagents containing primary antibodies for research use; chemical reagents and medical preparations for research purposes; clinical research reagents; chemical reagents for medical or veterinary research purposes, namely reagents for immuno-histochemistry detection and in situ-hybridisation detection; in situ-hybridisation probes for medical research purposes; epitope retrieval solutions for medical research purposes; enzymes and enzyme preparations for medical research purposes; histological dye and stain solutions for medical research purposes; dewaxing and wash buffers used with the aforementioned preparations; fluorescent dyes and fluorescent labels for diagnostic use; assay reagents for diagnostic use; aptamers for diagnostic use; affinity reagents for diagnostic use; supramolecular host-guest systems for diagnostic use; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for diagnostic use; kits comprising a combination of any of the aforesaid research reagents, preparations for medical and veterinary research, clinical research reagents, in situ-hybridisation probes, epitope retrieval solutions, enzymes and enzyme preparations, histological dyes and stain solutions, dewaxing and wash buffers, fluorescent dyes and fluorescent labels, assay reagents, aptamers, affinity reagents, supramolecular host-guest systems, reagents containing primary antibodies, affimers, or other affinity reagents, nucleic acid probes, non-optically detectable labels, blocking agents and inactivation agents, all for diagnostic and medical research purposes.

Produits et services

(1) Chemicals for use in industry and science; chemical reagents for non-medical purposes; reagents for research purposes; research reagents and preparations, except for medical or veterinary use; research preparations used in science; chemical reagents and diagnostic preparations for use in research laboratories and for use in industry; fluorescent dyes and fluorescent labels for applications in industry and science; assay reagents for use in research, quality control, diagnostic use; aptamers for use in research, quality control; affinity reagents for use in research or quality control; supramolecular host-guest systems for use in research or quality control; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for research use; kits comprising a combination of any of the aforesaid chemical reagents, research reagents and preparations, assay reagents, affinity reagents, supramolecular host-guest systems, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents and inactivation agents, all for industrial, scientific and research use. (2) Research preparations, namely antibodies or nucleic acid probes, for the investigation of disease models; preparations for medical and veterinary research; reagents containing primary antibodies for research use; chemical reagents and medical preparations for research purposes; clinical research reagents; chemical reagents for medical or veterinary research purposes, namely reagents for immuno-histochemistry detection and in situ-hybridisation detection; in situ-hybridisation probes for medical research purposes; epitope retrieval solutions for medical research purposes; enzymes and enzyme preparations for medical research purposes; histological dye and stain solutions for medical research purposes; dewaxing and wash buffers used with the aforementioned preparations; fluorescent dyes and fluorescent labels for diagnostic use; assay reagents for diagnostic use; aptamers for diagnostic use; affinity reagents for diagnostic use; supramolecular host-guest systems for diagnostic use; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for diagnostic use; kits comprising a combination of any of the aforesaid research reagents, preparations for medical and veterinary research, clinical research reagents, in situ-hybridisation probes, epitope retrieval solutions, enzymes and enzyme preparations, histological dyes and stain solutions, dewaxing and wash buffers, fluorescent dyes and fluorescent labels, assay reagents, aptamers, affinity reagents, supramolecular host-guest systems, reagents containing primary antibodies, affimers, or other affinity reagents, nucleic acid probes, non-optically detectable labels, blocking agents and inactivation agents, all for diagnostic and medical research purposes.

Produits et services

(1) Chemicals for use in industry and science; chemical reagents for non-medical purposes; reagents for research purposes; research reagents and preparations, except for medical or veterinary use; research preparations used in science; chemical reagents and diagnostic preparations for use in research laboratories and for use in industry; fluorescent dyes and fluorescent labels for applications in industry and science; assay reagents for use in research, quality control, diagnostic use; aptamers for use in research, quality control; affinity reagents for use in research or quality control; supramolecular host-guest systems for use in research or quality control; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for research use; kits comprising a combination of any of the aforesaid chemical reagents, research reagents and preparations, assay reagents, affinity reagents, supramolecular host-guest systems, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents and inactivation agents, all for industrial, scientific and research use. (2) Research preparations, namely antibodies or nucleic acid probes, for the investigation of disease models; preparations for medical and veterinary research; reagents containing primary antibodies for research use; chemical reagents and medical preparations for research purposes; clinical research reagents; chemical reagents for medical or veterinary research purposes, namely reagents for immuno-histochemistry detection and in situ-hybridisation detection; in situ-hybridisation probes for medical research purposes; epitope retrieval solutions for medical research purposes; enzymes and enzyme preparations for medical research purposes; histological dye and stain solutions for medical research purposes; dewaxing and wash buffers used with the aforementioned preparations; fluorescent dyes and fluorescent labels for diagnostic use; assay reagents for diagnostic use; aptamers for diagnostic use; affinity reagents for diagnostic use; supramolecular host-guest systems for diagnostic use; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for diagnostic use; kits comprising a combination of any of the aforesaid research reagents, preparations for medical and veterinary research, clinical research reagents, in situ-hybridisation probes, epitope retrieval solutions, enzymes and enzyme preparations, histological dyes and stain solutions, dewaxing and wash buffers, fluorescent dyes and fluorescent labels, assay reagents, aptamers, affinity reagents, supramolecular host-guest systems, reagents containing primary antibodies, affimers, or other affinity reagents, nucleic acid probes, non-optically detectable labels, blocking agents and inactivation agents, all for diagnostic and medical research purposes.

Produits et services

Chemicals for use in industry and science; chemical reagents for non-medical purposes; reagents for research purposes; research reagents and preparations, except for medical or veterinary use; research preparations used in science; chemical reagents and diagnostic preparations for use in research laboratories and for use in industry; fluorescent dyes and fluorescent labels for applications in industry and science; assay reagents for use in research, quality control, diagnostic use; aptamers for use in research, quality control; affinity reagents for use in research or quality control; supramolecular host-guest systems for use in research or quality control; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for research use; kits comprising a combination of any of the aforesaid chemical reagents, research reagents and preparations, assay reagents, affinity reagents, supramolecular host-guest systems, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents and inactivation agents, all for industrial, scientific and research use. Research preparations, namely antibodies or nucleic acid probes, for the investigation of disease models; preparations for medical and veterinary research; reagents containing primary antibodies for research use; chemical reagents and medical preparations for research purposes; clinical research reagents; chemical reagents for medical or veterinary research purposes, namely reagents for immuno-histochemistry detection and in situ-hybridisation detection; in situ-hybridisation probes for medical research purposes; epitope retrieval solutions for medical research purposes; enzymes and enzyme preparations for medical research purposes; histological dye and stain solutions for medical research purposes; dewaxing and wash buffers used with the aforementioned preparations; fluorescent dyes and fluorescent labels for diagnostic use; assay reagents for diagnostic use; aptamers for diagnostic use; affinity reagents for diagnostic use; supramolecular host-guest systems for diagnostic use; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for diagnostic use; kits comprising a combination of any of the aforesaid research reagents, preparations for medical and veterinary research, clinical research reagents, in situ-hybridisation probes, epitope retrieval solutions, enzymes and enzyme preparations, histological dyes and stain solutions, dewaxing and wash buffers, fluorescent dyes and fluorescent labels, assay reagents, aptamers, affinity reagents, supramolecular host-guest systems, reagents containing primary antibodies, affimers, or other affinity reagents, nucleic acid probes, non-optically detectable labels, blocking agents and inactivation agents, all for diagnostic and medical research purposes.

Produits et services

Chemicals for use in industry and science; chemical reagents for non-medical purposes; reagents for research purposes; research reagents and preparations, except for medical or veterinary use; research preparations used in science; chemical reagents and diagnostic preparations for use in research laboratories and for use in industry; fluorescent dyes and fluorescent labels for applications in industry and science; assay reagents for use in research, quality control, diagnostic use; aptamers for use in research, quality control; affinity reagents for use in research or quality control; supramolecular host-guest systems for use in research or quality control; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for research use; kits comprising a combination of any of the aforesaid chemical reagents, research reagents and preparations, assay reagents, affinity reagents, supramolecular host-guest systems, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents and inactivation agents, all for industrial, scientific and research use. Research preparations, namely antibodies or nucleic acid probes, for the investigation of disease models; preparations for medical and veterinary research; reagents containing primary antibodies for research use; chemical reagents and medical preparations for research purposes; clinical research reagents; chemical reagents for medical or veterinary research purposes, namely reagents for immuno-histochemistry detection and in situ-hybridisation detection; in situ-hybridisation probes for medical research purposes; epitope retrieval solutions for medical research purposes; enzymes and enzyme preparations for medical research purposes; histological dye and stain solutions for medical research purposes; dewaxing and wash buffers used with the aforementioned preparations; fluorescent dyes and fluorescent labels for diagnostic use; assay reagents for diagnostic use; aptamers for diagnostic use; affinity reagents for diagnostic use; supramolecular host-guest systems for diagnostic use; reagents containing primary antibodies, aptamers, affimers, or other affinity reagents, nucleic acid probes, fluorescent dyes, fluorescent labels, non-optically detectable labels, blocking agents, inactivation agents for diagnostic use; kits comprising a combination of any of the aforesaid research reagents, preparations for medical and veterinary research, clinical research reagents, in situ-hybridisation probes, epitope retrieval solutions, enzymes and enzyme preparations, histological dyes and stain solutions, dewaxing and wash buffers, fluorescent dyes and fluorescent labels, assay reagents, aptamers, affinity reagents, supramolecular host-guest systems, reagents containing primary antibodies, affimers, or other affinity reagents, nucleic acid probes, non-optically detectable labels, blocking agents and inactivation agents, all for diagnostic and medical research purposes.

Abrégé

The invention relates to compounds of the general formulae (I)-(IV), which are characterized by substituents B comprising one or more sulfonic acid groups and their use as marker groups for the detection of analytes.

Classes IPC  ?

• C09B 1/34 - Colorants à groupes amine substitués par des radicaux hydrocarbonés substitués par des groupes aryle sulfonés
• C07D 311/88 - Atomes d'azote
• C07C 301/00 - Esters d'acide sulfureux
• C07C 309/31 - Acides sulfoniques ayant des groupes sulfo liés à des atomes de carbone de cycles aromatiques à six chaînons d'un squelette carboné de cycles aromatiques à six chaînons non condensés de cycles aromatiques à six chaînons substitués par des groupes alkyle par des groupes alkyle contenant au moins trois atomes de carbone
• C07C 323/62 - Thiols, sulfures, hydropolysulfures ou polysulfures substitués par des halogènes, des atomes d'oxygène ou d'azote ou par des atomes de soufre ne faisant pas partie de groupes thio contenant des groupes thio et des groupes carboxyle liés au même squelette carboné ayant l'atome de soufre d'au moins un des groupes thio lié à un atome de carbone d'un cycle aromatique à six chaînons du squelette carboné
• C07D 405/10 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne carbonée contenant des cycles aromatiques
• C07D 471/04 - Systèmes condensés en ortho
• C07C 13/00 - Hydrocarbures cycliques contenant des cycles autres que des cycles aromatiques à six chaînons, avec ou sans cycles aromatiques à six chaînons
• C07F 7/08 - Composés comportant une ou plusieurs liaisons C—Si
• C07D 215/10 - Composés quaternaires
• C09B 5/42 - Pyridinoanthraquinones
• C09B 57/02 - Colorants coumariniques
• G01N 21/64 - FluorescencePhosphorescence

Produits et services

Chemicals used in industry, science and photography, as well as in agriculture, horticulture and forestry. Pharmaceutical products except therapeutics for dermatology and oncology. Scientific instruments.

Produits et services

Chemicals used in industry, science and photography, as well as in agriculture, horticulture and forestry. Pharmaceutical products except therapeutics for dermatology and oncology. Scientific instruments.

Abrégé

7 on the central carbon atom of the chromophore, to processes for their preparation, and to the use thereof for the determination of analytes.

Classes IPC  ?

• G01N 21/64 - FluorescencePhosphorescence
• C09B 11/28 - Pyronines
• G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées

Abrégé

The invention relates to polycyclic compounds of general formula (I) which are characterized by an amine substituent NR6R7 at the central carbon atom of the chromophore, to methods for producing said polycyclic compounds, and to the use of said polycyclic compounds to identify analytes.

Classes IPC  ?

• C09B 11/28 - Pyronines
• G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées