One or more temperature control units are distributed throughout an environment to provide localized heating and cooling. The temperature control units include a thermal storage system including one or more substances of high latent heat capacity, a heat distribution surface, a solid-state heat pump positioned between the thermal storage system and the heat distribution surface, an environmental sensing module including a proximity sensor, and unit control modules in communication with the solid-state heat pumps. The solid-state heat pumps are individually controllable so that heating and cooling can be provided simultaneously from separate heat pumps in the same temperature control unit, or separate temperature control units in the same environment. The system also senses the presence and location of an individual in the environment, and turns the distributed temperature control units on and off accordingly to provide optimum heating and cooling to the individual without heating or cooling the entire environment.
The composition inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) via competitive binding to SARS-CoV-2 spike protein. The composition includes a plurality of sulfated glycosaminoglycans which bind to SARS-CoV-2 spike protein, preventing binding to and uptake by host cells. The sulfated glycosaminoglycans, including N-, 2-O, 3-O, or 6-O sulfate groups, or combinations thereof, include heparins and fucoidans, such as those isolated from brown seaweed. The compositions show antiviral activity, with EC50 as low as 0.08 μM, and low cytotoxicity, making it promising for clinical use. While established SARS-CoV-2 treatments such as remdesivir need to be administered intravenously, the compositions discussed herein are advantageously capable to being delivered as a nasal spray, metered dose inhaler, oral delivery, etc.
A membrane for separating organic solvents such as methanol and toluene is provided. A plurality methacrylate polymer brushes, e.g., composed of hydroxyethyl methacrylate (HEMA) monomers or aminoethyl methacrylate (AEMA) monomers, are grafted from a crosslinked polyimide support using Single Electron Transfer-Living Radical Polymerization (SET-LRP). The polymer brushes themselves are also crosslinked by ethylene glycol dimethacrylate (EGDMA), triethylene glycol dimethacryalte (TEGDMA) trimesic acid, and/or itaconic acid. These hydrophilic polymeric brush membranes demonstrate pore stiffening and yet also opening, obtaining high selectivity at reasonable permeability and reduced energy requirements for commercially relevant separations, e.g., methanol/toluene. The addition of the crosslinker prevents loss of selectivity as a result of imparting increased rigidity, enabling the membranes to be operated at higher operating pressures for increased throughput. These membranes would be beneficial for use in pharmaceutical, chemical, petroleum, food, and biotechnology industries, e.g., in the manufacture of polymethacrylic acid, the manufacture of paraxylene, etc.
B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
A cross-connect switch architecture is described. A cross-connect switch device includes a cross-point switch array, a plurality of photo detectors and a plurality of amplifiers. The cross-point switch array includes a plurality of switches. Each switch is coupled between a respective photo detector and a respective amplifier and is configured to couple the respective photo detector to the respective amplifier when the switch is selected.
H04Q 11/00 - Selecting arrangements for multiplex systems
H03F 3/08 - Amplifiers with only discharge tubes or only semiconductor devices as amplifying elements with semiconductor devices only controlled by light
The present disclosure provides methods related to the purification of a biologic. In particular, the present disclosure methods for purifying a biologic using a multifunctional chromatography medium comprising porous beads or particles having a defined pore diameter distribution and one or more ligands conjugated to the surface of the pores capable of removing process-related impurities and product-related impurities from a target biologic.
C07K 1/16 - ExtractionSeparationPurification by chromatography
B01D 15/34 - Size-selective separation, e.g. size-exclusion chromatographyGel filtrationPermeation
B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
Source and target vectors encode roles of a node in a directed graph as a source and a target role respectively. Source and target query matrices and source and target key matrices are learned based on the directed graph. The source query matrix and the target key matrix are projected and scaled to create a source-target attention matrix and the target query matrix and the source key matrix are projected and scaled to create a target-source attention matrix. The attention matrices are combined to generate a source-target vector-edge encoding and a target-source vector-edge encoding, and are also biased and gated to generate a modified source-target attention matrix and a modified target-source attention matrix, respectively. Source encodings and target encodings are generated using the modified attention matrices. A classification task is performed with respect to the obtained directed graph based on the generated source encodings and the generated target encodings.
Separation constructs such as membranes, porous beads, etc. are modified with a plurality of oligomeric ligands. The ligands are bound to the surface of the separation substrates via linker constructs such as acrylate groups or azide groups, e.g., via Single-Electron Transfer-Living Radical Polymerization (SET-LRP). A plurality of spacer constructs, such as polyethyleneglycol (PEG) groups and hydrocarbyl groups, separate the linker constructs from oligomer constructs. The oligomer constructs can include between 5% and about 10% guanine and about 90% to about 95% thymine, and can further include between about 20 and about 60 nucleotides including at least 15 thymines and at least 1 guanine. The oligomer constructs exhibit improved binding of mRNA with oligo-dAn tails, e.g., for purification of mRNA production and commercialization, enabling fast, efficient, and continuous production of mRNA vaccines such as those against coronaviruses, e.g., SARS-CoV-2.
Disclosed herein are novel microbial polycultures of two or more cell strains, capable of producinges, flavonoids, and anthocyanidin-3-O-glucosides, and methods of use thereof. Also disclosed is a microbial cell capable of producing phenylpropanoic acids, and methods of use thereof.
C12P 19/58 - Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound through only acyclic carbon atoms to a non-saccharide heterocyclic ring, e.g. bleomycin, phleomycin
C12N 9/00 - Enzymes, e.g. ligases (6.)ProenzymesCompositions thereofProcesses for preparing, activating, inhibiting, separating, or purifying enzymes
A machine learning model is trained using original source domain data through empirical risk minimization and a model sensitivity map is computed. Each sensitive frequency point on the model sensitivity map is targeted. An adversarial technique is employed to generate spectral adversarial images based on the model sensitivity map and an image amplitude spectrum is augmented. The generated spectral adversarial images are mixed with the original source domain data to finetune the machine learning model and deployment of the finetuned machine learning model is facilitated.
G06V 10/80 - Fusion, i.e. combining data from various sources at the sensor level, preprocessing level, feature extraction level or classification level
10.
SYSTEMS AND METHODS OF MULTI-MODAL MULTI-DIMENSIONAL IMAGE REGISTRATION
Multi-modal image registration in which a fixed image from a first imaging device is received; a moving image from a second imaging device is received, comprising a plurality of moving image frames. For each moving image frame: a set of candidate fixed image slices from the fixed image are identified based on a set of geometric parameters derived from an application of a template moving image to the fixed image. Feature extraction is performed on the candidate fixed image slices and on each moving image frame. A candidate feature vector from the set of candidate feature vectors with the highest similarity to each moving image feature vector is identified, and a location for each moving image feature vector relative to the fixed image is assigned based on the location of the identified candidate feature vector.
A NFCBRS system for installation on a surface of a building includes a body and one or more spacers. The body includes a core that includes a natural fiber wool that is bonded together and a composite skin that covers the core and includes a natural fiber impregnated with a thermoset resin. The one or more spacers are structured to be positioned between the body and a surface of a building to define a ventilation cavity between the body and the surface of the building. The ventilation cavity is structured to inhibit a build-up of moisture between the surface of the building and the body.
B32B 5/06 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by structural features of a layer comprising fibres or filaments characterised by a fibrous layer needled to another layer, e.g. of fibres, of paper
E04B 1/10 - Structures consisting primarily of load-supporting, block-shaped or slab-shaped elements the elements consisting of wood
A multicopter rotor fault diagnosis system includes a multicopter, a plurality of local sensors, and a controller. The multicopter includes a body, a plurality of booms secured to the body, and a plurality of rotors. Each boom has a proximal end secured to the body and extends radially outward to a distal end. Each rotor is secured to the distal end of a respective boom. Each sensor is secured to a respective boom and is positioned a distance from the body. The local sensors are configured to measure out-of-plane strain of the booms and to continuously generate boom strain signals. The controller is in communication with the body and the local sensors. The controller is configured to receive the continuously generated boom strain signals and to perform a pattern recognition algorithm to simultaneously detect and identify faults associated with the rotors.
For at least a first two iterations: for candidate training algorithms, obtain from clients, a score corresponding to a best hyperparameter, based on a fraction of available training data; for the algorithms, aggregate the scores and update a projected score for each of the algorithms; and increase the fraction of available training data to be used in a subsequent one of the at least a first two iterations or a first one of a plurality of subsequent iterations. For the subsequent iterations: for a best-performing subset of the algorithms, obtain from the clients, an updated best hyperparameter and corresponding score, based on a further increased fraction of available training data as compared to a final iteration of at least first two iterations or a previous one of the subsequent iterations; and for the best-performing subset, aggregate the obtained updated scores and further update a projected score for each subset member.
The systems and methods convert methane to one or more products using a green rust material in spontaneous, electrocatalytic, and photochemical reactions under aerobic and anaerobic conditions. In an embodiment, a first electrode that includes a green rust material and a second electrode are contacted by an electrolyte, where the first and second electrodes are separated by an ion exchange membrane. For electrocatalytic reactions, a potential difference is applied across the electrodes. For photochemical reactions, the green rust material is illuminated. Liquid products (e.g., methanol and/or acetate) can be removed from the electrolyte in contact with the green rust material after the desired contact period.
C01B 3/26 - Production of hydrogen or of gaseous mixtures containing hydrogen by decomposition of gaseous or liquid organic compounds of hydrocarbons using catalysts
C01B 3/40 - Production of hydrogen or of gaseous mixtures containing hydrogen by reaction of gaseous or liquid organic compounds with gasifying agents, e.g. water, carbon dioxide, air by reaction of hydrocarbons with gasifying agents using catalysts characterised by the catalyst
A system for free-space optical communication includes a first light source configured to emit an information signal, a spatial light modulator configured to shape the information signal, a second light source configured to emit a plurality of beam pulses, at least one spiral phase plate configured to convert each of the plurality of beam pulses into a plurality of vortical beam filaments, and a mirror coupler configured to combine the information signal and the plurality of vortical beam filaments to form a multi-filament beam having the plurality of vortical beam filaments embedded within the information signal. When the multi-filament beam passes through an optically obstructed space the plurality of vortical beam filaments are configured to clear at least one channel in the optically obstructed space for the information signal to pass through.
Customized recombinant proteins are designed and produced by cultures of Pseudomonas bacteria, including natural and recombinant silk proteins, fluorescent proteins, and elastin-like proteins (ELPs). The recombinant genes can be expressed via insertion directly into the Pseudomonas bacteria, or via the transformation of a suitably designed recombinant plasmid. Advantageously, the carbon source used as the nutrient source by the Pseudomonas bacteria is derived from non-traditional nutrient sources, such as exogenous rhamnolipids, hydrocarbons, polyolefins, polyesters, and pyrolysis products of waste plastic, e.g., pyrolysis products of polyethylene or poly (ethylene terephthalate). The waste feedstocks can be added to particularly designed growth media for sustained bacterial culture and protein production. These feedstocks allow for upcycling of plastic waste into high value protein products, such as recombinant silk fibroins.
C08J 11/10 - Recovery or working-up of waste materials of polymers by chemically breaking down the molecular chains of polymers or breaking of crosslinks, e.g. devulcanisation
C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
C07K 14/78 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
C12N 15/78 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Pseudomonas
In one embodiment, there is provided a dissectography module for dissecting a two-dimensional (2D) radiograph. The dissectography module includes an input module, an intermediate module, and an output module. The input module is configured to receive a number K of 2D input radiographs, and to generate at least one three-dimensional (3D) input feature set, and K 2D input feature sets based, at least in part, on the K 2D input radiographs. The intermediate module is configured to generate a 3D intermediate feature set based, at least in part, on the at least one 3D input feature set. The output module is configured to generate output image data based, at least in part, on the K 2D input feature sets, and the 3D intermediate feature set. Dissecting corresponds to extracting a region of interest from the 2D input radiographs while suppressing one or more other structure(s).
Financial engineering asset securitization principles are employed to carve out "risk-free" power generation capability from renewable assets, e.g., wind and solar. Dynamically evolving tranches of renewable power are defined that allow renewable power generators to participate in day-ahead power markets with bids competitive with those for conventionally-derived power. Historical data sets containing, e.g., renewable power generation mean, spread, maximum, minimum, and forecast, are used to define a. characteristic day projection. A tranche of renewable power generated during each hour is prepared based on the characteristic day projection, using the 4th percentile of generated power as the attachment point and the 5th-7th percentile as detachment point, corresponding to a 96% likelihood of successfully fulfilling a bid contract, competitive with conventionally-derived power. Bid price curves are prepared for each hour, and a bid for the day-ahead market composed of the bid price curves is prepared. A rating indicating how likely a renewable generator will fulfill a contract's obligations can be provided as well.
19.
RAPID AND FACILE MEMBRANE ADSORBER FABRICATION WITH ULTRA HIGH BINDING CAPACITY
Functionalized membranes are produced via grafting of polymer brushes to the membrane surface for use, e.g., in separation and purification of biomolecules. One or more initiators are attached to the membrane surface. A reactant substrate, such as a copper metal plate, is placed adjacent the membrane. A reaction medium is then provided in fluid contact with the membrane and the reactant substrate, the reaction medium including one or more monomers, one or more ligands, and one or more solvents. The polymer brushes are grown on the membrane via Cu(0)-mediated controlled radical polymerization involving the reactant substrate and the reaction medium. This reaction process uses fewer numbers and amounts of chemicals compared to other controlled radical polymerization reactions such as ATRP. The reaction can take place at room temperature, which is more energy efficient than other CRPs which occur at a much higher temperatures. The reaction process described herein is also sixteen times faster than the standard ATRP method without sacrificing subsequent separation performance.
B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
B01D 71/82 - Macromolecular material not specifically provided for in a single one of groups characterised by the presence of specified groups, e.g. introduced by chemical after-treatment
C08J 7/16 - Chemical modification with polymerisable compounds
G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
20.
MANIPULATION OF GASEOUS ION BEAMS WITH ACOUSTIC FIELDS
An apparatus for manipulation of a gaseous ion beam advantageously uses an ultrasonic acoustic field rather than physical structures, which can become contaminated or electromagnetic fields, which require high field strengths. Such apparatuses comprise an ion source having an outlet configured to release the gaseous ion beam at a flow rate along a first path; a transducer configured to generate an acoustic field along a second path that intersects or overlaps with the first path; and an ion detector. Aspects of the disclosure also provide methods of using the same to deflect, gate, focus, and separate gaseous ion beams.
Systems for capturing handwriting or other data corresponding to the movement of a stylus are provided. In some embodiments, such systems include an electronic inscription device with a flexible display screen that is extendable from and retractable into one or more housings. The device includes stylus position sensing circuitry for capturing data corresponding to movement of a stylus relative to the flexible display screen. In some embodiment, one or more of the housings include retraction and locking components that hold the screen in an extended position for use. In some embodiments, the stylus position sensing circuitry senses infrared signals from the tip of a stylus. In some embodiments, the system also includes a stylus with an infrared strobe tip.
A CT apparatus in which the x-ray source is coupled to a source robotic arm and the detector is coupled to a detector robotic arm. A motion correction module utilizes a locally linear embedding motion correction algorithm with normalized cross correlation to estimate the geometric parameters associated with the positions of the source and detector and the angle of the detector. These estimates are used to reconstruct the image data and produce corrected images with fewer errors resulting from patient movement, misalignments, and coordination issues in the system.
NOVEL CO-DRUG, CO-ADMINISTRATION, AND SEQUENTIAL ADMINISTRATION OF SELECTIVE TTR LIGAND AND C20-D3-RETINOL FOR ELIMINATION OF MECHANISM-BASED OCULAR ADVERSE EFFECTS IN TREATING MACULAR DEGENERATION AND TTR AMYLOIDOSIS
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (USA)
RENSSELAER POLYTECHNIC INSTITUTE (USA)
Inventor
Petrukhin, Konstantin
Cioffi, Christopher, L.
Abstract
New therapies for macular degeneration and TTR amyloidosis are provided based on a co-drug that represents a conjugate of two distinct chemical entities as well as co- administration and sequential administration of the two chemical entities. The first component ("selective TTR ligand") is a chemical entity that engages TTR (transthyretin) of the RBP4 (retinol binding protein 4) -TTR complex, which is involved in delivery of retinol to the retina. This component reduces traffic of retinol from circulation to the retina and provides stabilization of TTR tetramers. The second component ("C20-D3-visual- chromophore-producing compound") is a C20-D3-modified retinoid or carotenoid that upon metabolism in a mammal can eventually produce a C20-D3 visual chromophore that represents C20-D3-9-cis-retinaldehyde or C20-D3-11-cis-retinaldehyde in the retina. Deuteration at the C20 position reduces the formation of lipofuscin bisretinoid while other functions (such as providing a precursor for in vivo synthesis of the visual chromophore, 11-cis-retinaldehyde) are not reduced.
A61K 47/55 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
24.
NOVEL CO-DRUG, CO-ADMINISTRATION, AND SEQUENTIAL ADMINISTRATION OF SELECTIVE RBP4 ANTAGONIST AND C20-D3-RETINOL FOR ELIMINATION OF MECHANISM-BASED OCULAR ADVERSE EFFECTS IN TREATING MACULAR DEGENERATION, NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD), AND GOUTY ARTHRITIS (GOUT)
A61K 47/55 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
25.
CONTRACEPTIVE VACCINE BASED ON THE SPERM-ASSOCIATED PROTEIN CATSPER
A composition includes a contraceptive chimeric virus-like particle with an antigenic carrier domain and one or more antigenic regions from a sperm cell in the antigenic carrier domain, with the antigenic carrier domain including human papillomavirus L1 capsid protein and the antigenic regions including one or more structural elements of the Catsper ion channel complex. When administered to a patient, the contraceptive vaccine stimulates production of anti-sperm antibodies that, upon binding to a sperm cell, inhibit the sperm cell's motility and thus inhibit the ability of the sperm cell to fertilize an egg cell. The induced immunoinfertility of the composition can be reversed for brief or extended lengths of time by overdosing the patient with a reversal agent lacking the antigenic carrier domain but having a protein sequence substantially identical to that of the one or more antigenic regions to sequester the anti-sperm antibodies.
A61K 39/00 - Medicinal preparations containing antigens or antibodies
26.
NOVEL CO-DRUG, CO-ADMINISTRATION, AND SEQUENTIAL ADMINISTRATION OF BISPECIFIC RBP4/TTR LIGAND AND C20-D3-RETINOL FOR ELIMINATION OF MECHANISM-BASED OCULAR ADVERSE EFFECTS IN TREATING MACULAR DEGENERATION AND TTR AMYLOIDOSIS
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (USA)
RENSSELAER POLYTECHNIC INSTITUTE (USA)
Inventor
Petrukhin, Konstantin
Cioffi, Christopher, L.
Abstract
New therapies for macular degeneration and TTR amyloidosis are provided based on a co-drug that represents a conjugate of two distinct chemical entities as well as co- administration and sequential administration of the two chemical entities. The first component ("bispecific RBP4 /TTR ligand") is a chemical entity that engages TTR ( transthyretin) and RBP4 ( retinol binding protein 4 ) of the RBP4 -TTR complex, which is involved in delivery of retinol to the retina. This component reduces traffic of retinol from circulation to the retina and provides stabilization of TTR tetramers. The second component ("C20-D3-visual-chromophore-producing compound" ) is a C20 -D3 -modified retinoid or carotenoid that upon metabolism in a mammal can eventually produce a C20-D3 visual chromophore that represents C20 -D3- 9-cis-retinaldehyde or C20-D3-11-cis-retinaldehyde in the retina. Deuteration at the C20 position reduces the formation of lipofuscin bisretinoid while other functions ( such as providing a precursor for in vivo synthesis of the visual chromophore, 11-cis-retinaldehyde ) are not reduced.
C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
C07D 403/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
27.
MULTI-SENSOR SYSTEMS AND METHODS FOR PROVIDING IMMERSIVE VIRTUAL ENVIRONMENTS
A time-of-flight (TOF) array including a plurality of cameras is positioned with a coplanar Higher Order Ambisonics (HOA) array including a plurality of microphones above a target area such as a room or space for analyzing speaker activity in that area. The HOA microphone array iteratively samples sound energy level frames captured by the microphones to identify a sound vector associated with the global maximum energy level in the sound energy level frame. This sound vector is fused with the data from the TOF camera array that identified the positions of sound sources in the target area to associate produced sound corresponding with the sound vector with a physical active sound source in the target area. A beamformer can then be used to save audio corresponding to the sound vector and discard audio not associated with the sound vector to produce a sound recording associated with the active sound source.
Materials, methods, and systems for affinity membrane purification of nucleic acid products advantageously (i) reduce the residence times of the recovery process, (ii) allow continuous processing, (iii) retain a higher percentage of nucleic acids having the target structure, and (iv) reduce the "footprint" of the equipment. Systems include one or more bioreactors to synthesize nucleic acids. One or more affinity membrane separators modified by the inclusion of a peptide obtained using rational design, in silico optimization, and/or combinatorial screening. One or more diafiltration modules include flat sheet microporous membranes, cellulose hollow fiber microporous affinity membranes, or combinations thereof.
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
C12M 1/00 - Apparatus for enzymology or microbiology
C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
G16B 5/00 - ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
A61K 39/215 - Coronaviridae, e.g. avian infectious bronchitis virus
Various systems and methods are provided for MAR in CT images. A corrupted CT image, of a region of interest (ROI) of a subject, including artifacts caused by a metal object in the subject may be acquired. A corrupted sinogram including a corrupted region of corrupted data caused by the metal object and an uncorrupted region of uncorrupted data may be generated. A mask sinogram that delineates the corrupted region of the corrupted data may be generated. A corrected sinogram including the uncorrupted region of the uncorrupted data and an inpainted region of inpainted data corresponding to the corrupted region may be generated using a denoising diffusion probabilistic model, the corrupted sinogram, and the mask sinogram. A corrected CT image, of the ROI of the subject, that includes reduced artifacts relative to the artifacts in the corrupted CT image may be generated based on the corrected sinogram.
Methods and systems are directed to multiplex detection of a bacterial pathogen in a sample. A first biotinylated lysin-derived cell wall binding domain is complexed with an avidin layer on a surface. A first bacterial pathogen detection complex including a second biotinylated lysin-derived cell wall binding domain, a detection domain, and an avidin linker complexed between the cell wall binding domain and the detection domain is also provided. The cell wall binding domains are derived from an endolysin, autolysin, bacteriocin, or exolysin, and are configured to bind a cell wall of a target bacterial pathogen. The detection domain includes one or more enzymes, fluorescent material, or DNA for emitting a signal for detection. Target bacterial pathogens present in a sample can thus be detected in a sandwich assay exhibiting increased selectivity and reduced limit of detection relative to traditional ELISA.
G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
C12Q 1/26 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving oxidoreductase
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
31.
SYSTEMS AND METHODS INCLUDING FUSED PARTICLE MEMBRANES FOR FILTRATION
Rigid or flexible polymer membranes including one contiguous porous film are provided that include a plurality of fused microstructures, e.g., microspheres, teardrops, ellipsoids, other geometric designs, or combinations thereof. The microstructures are fused via a sintering, chemical, and/or physical process, crosslinking, or combinations thereof. The membranes have a plurality of repeating microstructures in a random or ordered, e.g., face-centered cubic, arrangement and a network of throats extending through the membrane and around the fused microstructures. The microstructures and throats precisely control the microstructure of the membrane, providing consistent and uniform flow across the membrane in all three directions. Channeling concerns of polymeric membranes cast using random statistical processes, such as phase inversion and interfacial polymerization, are thus reduced. The membranes provide consistent filtration performance, e.g., of proteins and nucleic acid mixtures, while reducing the compressibility, pore wall flexibility, and ageing limitations of traditional polymeric membranes. Surface modification of the microstructures can further enhance membrane selectivity for a given separation.
32.
METHOD FOR PRODUCING A MICROORGANISM HAVING N-DEACETYLATION ACTIVITY AND N-SULFATION ACTIVITY, METHOD FOR PRODUCING A HEPAROSAN-DERIVED COMPOUND, AND A MICROORGANISM HAVING N-DEACETYLATION ACTIVITY AND N-SULFATION ACTIVITY
The present invention relates to a method for producing a microorganism having N-deacetylation activity and N-sulfation activity, including a step (I) of modifying a nucleotide sequence of a DNA encoding N-deacetylase/N-sulfotransferase, and a step (II) of introducing the DNA containing the nucleotide sequence modified in the step (I) into a microorganism in an expressible manner, wherein the step (I) is a step of performing codon optimization according to the codon usage frequency of a biological species different from the microorganism. Further, the invention relates to a method for producing a microorganism having N-deacetylation activity and N-sulfation activity, including a step (i) of expressing a specific protein in a microorganism.
Systems, methods, and software that generate synthetic image data based on an original dataset. Some embodiments utilize a variational autoencoder trained on an original dataset to generate a latent space dataset to train a denoising diffusion model to generate synthetic latent space data which is then converted to a synthetic image by the trained decoder circuitry of the variational autoencoder. Some embodiments include enhanced privacy protection in which the original images and the synthetic images are converted to vectors, the L2 distance between a synthetic image vector and each original image vector is compared, and synthetic images for which the L2 distance is below a selected threshold are removed from the synthetic dataset.
Systems, methods, and software for reconstructing sparse projection data to full projection data and refining the resulting image volume using denoising diffusion probabilistic models in both the projection and image domains. A trained DDPM in the projection domain is used to inpaint projection data into sparse sub-volumes of a sparce projection dataset. The repaired sub-volumes are assembled into an assembled full projection dataset, which is then reconstructed into an image volume. A trained DDPM in the image domain then refines sub-volumes of the reconstructed image volume to produce a refined tomographic image volume.
A system for producing rebar includes a pultruding machine configured to receive a flexible rebar preform. The flexible rebar preform includes at least one reinforcement filament, and at least one thermoplastic filament. The at least one reinforcement filament, and the at least one thermoplastic filament are arranged in a selected distribution across a cross-section of the preform. The pultruding machine includes a pulling apparatus, a rebar cutting apparatus, and a bending apparatus. The pultruding machine is configured to heat the flexible rebar preform to a first temperature. The first temperature is greater than or equal to a melt temperature of the thermoplastic filaments. The pulling apparatus is configured to pull the flexible rebar preform through a pultrusion die to form the rebar. The rebar cutting apparatus is configured to cut the rebar at a prespecified length. The bending apparatus is configured to bend the cut rebar to a prespecified bend geometry.
B29C 70/54 - Component parts, details or accessoriesAuxiliary operations
B29K 105/10 - Condition, form or state of moulded material containing reinforcements, fillers or inserts of continuous length, e.g. cords, rovings, mats, fabrics, strands or yarns oriented
Provided herein are conformation-specific antibodies which bind to protein aggregates, such as amyloid fibrils, including aggregates of glucagon and liraglutide. Also provided are methods of using the antibodies to detect protein aggregates in samples, and methods for identifying aggregate-binding antibodies.
22 to one or more multicarbon products using a green rust material in spontaneous and electrocatalytic reactions. In an embodiment, a first electrode that includes a green rust material and a second electrode are contacted by an electrolyte, where the first and second electrodes are separated by a proton exchange membrane. For electrocatalytic reactions, a potential difference is applied across the electrodes. Multicarbon products can be removed from the electrolyte in contact with the green rust material after the desired contact period.
B01J 20/02 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material
39.
SYNTHETIC NETWORK GENERATOR FOR COVERT NETWORK ANALYTICS
A method of generating a synthetic network includes receiving, by a group structure identification module, anonymized input data related to an original network. The anonymized input data includes an anonymized list of nodes, a list of edges and a list of groups. The method further includes determining, by the group structure identification module, for each pair of nodes, a probability of an edge between the pair of nodes. A resulting list of probabilities corresponds to a summary group structure. The method further includes generating, by a synthetic random network generation module, at least one synthetic random network based, at least in part, on the determined probabilities.
BacillusB. megateriumB. megateriumB. megateriumB. megateriumB. megaterium generate the protein product and further secrete that product into the growth media, mitigating toxicity of the disordered proteins and facilitating continuous thereof. Previous recombinant silk protein production methods suffered from low-yields and batch-production limitations.
A system for tissue staining includes an upper housing, a lower housing, and a microscope lens. The upper housing includes a first reservoir configured to retain a solution therein, a valve attached to the reservoir including a turning knob, a first conduit configured to transport the solution, and a funnel fluidly connected to the first conduit. The lower housing is threadedly couped to the upper housing. The lower housing includes a top cassette portion having a window, a bottom cassette portion having a recess configured to retain a tissue therein, and a gasket disposed along an outer perimeter of the bottom cassette portion. The upper portion and the lower housing are coupled via threading. The microscope lens is configured to image the tissue through the window.
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
42.
SYSTEMS AND METHODS FOR REMOVAL OF CLOT MATERIAL FROM A BLOOD VESSEL
Systems and methods for removing thromboembolic material from blood vessels, including a first, outer catheter, a second, inner catheter disposed inside of the first catheter, an elongate member disposed inside of the second catheter, and a stent arranged adjacent to the distal end of the second catheter. The stent can be expanded to encapsulate at least a portion of a thrombus, and the elongate member can be rotated to break down the thrombus for removal from the blood vessel. In one or more embodiments, the first catheter is provided with aspiration capability to assist in removal of the thrombus.
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
Syringes and syringe systems for use in centrifuge machines including coupling arms for engaging the centrifuge machines. The syringe including a housing with a first coupling arm extending from a first side of the housing and a second coupling arm extending from a second side of the housing. The first side is opposite the second side. The syringe also includes at least one plunger slidingly received within the housing. Methods of using the syringes and syringe system for extracting and injecting platelet-rich plasma are also disclosed.
44.
RECOMBINANT ENZYME FOR THE ACCURATE INSERTION OF DNA SEQUENCES IN EUKARYOTIC CELLS
A construct for site-specific insertion of DNA fragments and transgenes into a genome includes a recombinant enzyme. The enzyme includes a modified HIV-1 integrase (HIV IN) tetramer having a plurality of mutations to favor a heterodimer of heterodimers construction with first and second outer monomers bound to first and second inner monomers, respectively. Transcription Activator Like Effectors (TALEs) are bound to N-terminal regions of the outer monomers via polypeptide linkers. The two TALEs grant the enzyme sequence specificity and prevent non-specific interactions with a target DNA structure. The modified HIV IN monomers ensure binding of TALEs to the outer-most monomers and arrangement of the TALEs relative to the HIV IN's catalytic region. Polynucleotides are bound to inner monomers of the HIV IN. Upon transport to the nucleus, either alone or within a lentiviral capsid, the TALEs interact with the DNA to localize the HIV IN, which then integrates the polynucleotides.
A system for tissue staining includes an upper housing, a lower housing, and a microscope lens. The upper housing includes a first reservoir configured to retain a solution therein, a valve attached to the reservoir including a turning knob, a first conduit configured to transport the solution, and a funnel fluidly connected to the first conduit. The lower housing is threadedly couped to the upper housing. The lower housing includes a top cassette portion having a window, a bottom cassette portion having a recess configured to retain a tissue therein, and a gasket disposed along an outer perimeter of the bottom cassette portion. The upper portion and the lower housing are coupled via threading. The microscope lens is configured to image the tissue through the window.
In an embodiment, there is provided a medical multimodal-multitask foundation model (M3FM) circuitry. The M3FM circuitry includes an image data preprocessor circuitry, an image encoder circuitry, a text data preprocessor circuitry, a text encoder circuitry, and a task encoder circuitry. The image data preprocessor circuitry is configured to divide received medical image data into a plurality of image tokens, to encode respective image token physical size data for each image token, and to combine respective encoded image token physical size data with a respective image token embedding corresponding to each image token. The image encoder circuitry is configured to map an image embedding space to a task embedding space. The text data preprocessor circuitry is configured to divide received clinical data into a plurality of clinical text tokens. The text encoder circuitry is configured to encode a plurality of text token embeddings. The task encoder circuitry is configured to extract task-specific embedding features from multimodal token embeddings.
Recombinant E. coli strains and synthetic protein sequence designs are leveraged for production of disordered polypeptides such as spidroins and elastin-like peptides (ELPs). These disordered polypeptides, the high-titer production of which has proven difficult, include repeating structural motifs from a small selection of amino acid residues, resulting in lack of well-defined tertiary and quaternary structure. The recombinant E. coli include expression vectors with genes encoding for the disordered polypeptide product. Expression of these genes is controlled by a promoter that downregulates and substantially inhibits basal expression in the recombinant bacteria. Further, the recombinant bacteria include mutations to one or more stress-response genes from wild-type E. coli, such as yggw, yedv, yedw, yedy, spec, speb, uspc, hcha, loip, mltc, envz, ompr, yhgf, or hupb. The recombinant E. coli enable production of high titers of disordered protein product while minimizing the toxic effects thereof on the host.
A system for detecting occupants in a room is provided. The system includes at least one first sensor configured to establish a background color map of the room in an unoccupied state and to detect color shift data resulting from at least one occupant entering the room, at least one second sensor configured to determine height data of the at least one occupant, and a controller configured to receive the color shift data and the height data and to generate equipment-control signals to operate at least one occupant-centric system.
A hydronic system includes a partition, a first conduit embedded in a first side of the partition, a second conduit embedded in a second side of the partition, a first sheet of finishing material covering the first conduit, a second sheet of finishing material covering the second conduit, and at least one valve and at least one pump. The at least one valve and at least one pump are configured to control a flow of a fluid inside the first conduit and the second conduit. When the hydronic system is operating in an isolating mode, the fluid flows in a first closed loop through the first conduit and the fluid flows in a second closed loop through the second conduit. When the hydronic system is operating in a heat exchange mode, the fluid flows between the first conduit and the second conduit in a third closed loop.
F24D 3/14 - Tube and panel arrangements for ceiling, wall, or underfloor heating incorporated in a ceiling, wall or floor
E04C 2/52 - Building elements of relatively thin form for the construction of parts of buildings, e.g. sheet materials, slabs, or panels characterised by the shape or structure with special adaptations for auxiliary purposes, e.g. serving for locating conduits
F24D 19/10 - Arrangement or mounting of control or safety devices
F24F 5/00 - Air-conditioning systems or apparatus not covered by group or
A luminaire includes a frame, an ambient light source positioned within the frame adjacent a first end of the frame, a downlight light source positioned within the frame adjacent a second end of the frame, a diffuser connected to the frame and at least partially surrounding the ambient light source, and a reflector configured to direct light emitted by the downlight light source. A first driver is in electrical communication with the ambient light source and is configured to adjust the illuminance of the ambient light source. A second driver is in electrical communication with the downlight light source and is configured to adjust the illuminance of the downlight light source. A controller is in electrical communication with and send control signals to the drivers to change the light sources between a plurality of illuminance modes, which includes a circadian effective mode and a circadian ineffective mode.
Evaluating viral clearance of a sample including a drug of interest is performed via modified viral surrogate nanoparticles that mimic a target live virus equivalent. The nanoparticles include fluorescent materials and a viral surface-mimicking layer that physicochemically mimics the external surface of the target live virus equivalent. One or more capsid proteins of the live virus are bound to the nanoparticle core (for non-enveloped viruses) or incorporated into a lipid bilayer (for enveloped viruses). A process solution is formed by adding the nanoparticles to the sample. The solution is subjected to purification steps to eliminate impurities, forming a product process solution. The product process solution is filtered through a dead-end flow nanofiltration membrane separator configured to bind the fluorescent nanoparticles. A load process solution is filtered as well. Baseline decomposition of the fluorescence intensity measurements from the separate membranes can, upon application of a standard curve indicate the relative nanoparticle concentration and thus the efficacy of the purification steps against the target live virus equivalent.
In one embodiment, there is provided an apparatus for ultra-low-dose (ULD) computed tomography (CT) reconstruction. The apparatus includes a low dimensional estimation neural network, and a high dimensional refinement neural network. The low dimensional estimation neural network is configured to receive sparse sinogram data, and to reconstruct a low dimensional estimated image based, at least in part, on the sparse sinogram data. The high dimensional refinement neural network is configured to receive the sparse sinogram data and intermediate image data, and to reconstruct a relatively high resolution CT image data. The intermediate image data is related to the low dimensional estimated image.
G06T 3/4046 - Scaling of whole images or parts thereof, e.g. expanding or contracting using neural networks
G06T 3/4053 - Scaling of whole images or parts thereof, e.g. expanding or contracting based on super-resolution, i.e. the output image resolution being higher than the sensor resolution
In an embodiment, there is provided a method for determining a spacecraft instantaneous velocity using starlight. The method includes determining, by a star pairing module, a plurality of star pairs in a selected star field image. The selected star field image includes a plurality of star images. The method includes estimating, by a line of sight estimation module, an apparent bearing direction to each star in at least some of the plurality of star pairs; determining, by the line of sight estimation module, a respective apparent inter-star angle for each star pair of the least some star pairs; and estimating, by a velocity estimation module, a spacecraft velocity to within a total velocity error based, at least in part, on the apparent inter-star angles.
An anion exchange membrane is composed of a copolymer of 1,1-diphenylethylene and one or more styrene monomers, such as 4-tert-butylstyrene. The copolymer includes a backbone substituted with a plurality of ionic groups coupled to phenyl groups on the backbone via hydrocarbyl tethers between about 1 and about 7 carbons in length. High-temperature conditions enabled by these copolymers enhance conductivity performance, making them particularly suitable for use in anion exchange membranes in fuel cells, electrolyzers employing hydrogen, ion separations, etc. The properties of the membranes can be tuned via the degree of functionalization of the phenyl groups and selection of the functional groups, such as quaternary ammonium groups. Several processes can be used to incorporate the desired ionic functional groups into the polymers, such as chloromethylation, radical bromination, Friedel-Crafts acylation and alkylation, sulfonation followed by amination, or combinations thereof.
The electrochemical energy conversion system include an anode, a cathode, and a proton exchange membrane disposed between the anode and the cathode. The proton exchange membrane includes a polymer having a hard block polymer, a soft block polymer, and one or more hydrophilic functional groups attached to the soft block polymer. The glass transition temperature of the hard block polymer is higher than a glass transition temperature of the soft block polymer, such that the hard block polymer is non-elastic and the soft block polymer is elastic at a desired operating temperature. The hydrophilic functional groups are attached to the soft block polymer via a thiol-ene reaction to modify double bonds in the soft block polymer. The swellable functional groups are selectively connected to the soft domains of the block copolymers, so that when the membrane swells (under hydration or gas adsorption), the stress is effectively absorbed by the soft domain and the impact on overall mechanical properties is minor, resulting in more durable membranes.
C08L 53/02 - Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bondsCompositions of derivatives of such polymers of vinyl aromatic monomers and conjugated dienes
H01M 8/1023 - Polymeric electrolyte materials characterised by the chemical structure of the main chain of the ion-conducting polymer having only carbon, e.g. polyarylenes, polystyrenes or polybutadiene-styrenes
H01M 8/1072 - Polymeric electrolyte materials characterised by the manufacturing processes by chemical reactions, e.g. insitu polymerisation or insitu crosslinking
H01M 8/1088 - Chemical modification, e.g. sulfonation
56.
ALKALINE ANION EXCHANGE MEMBRANES DERIVED FROM DIPHENYLETHYLENE AND CO-MONOMER FEEDSTOCK
The anion exchange membranes exhibit enhanced chemical stability and ion conductivity when compared with traditional styrene-based alkaline anion exchange membranes. A copolymer backbone is polymerized from a reaction medium that includes a diphenylalkylene and an alkadiene. The copolymer includes a plurality of pendant phenyl groups. The diphenyl groups on the polymer backbone are functionalized with one or more haloalkylated precursor substrates. The terminal halide from the precursor substrate can then be substituted with a desired ionic group. The diphenylethylene-based alkaline anion exchange membranes lack the α-hydrogens sharing tertiary carbons with phenyl groups from polystyrene or styrene-based precursor polymers, resulting in higher chemical stability. The ionic groups are also apart from each other by about 3 to 6 carbons in the polymer backbone, enhancing ion conductivity. These membrane are advantageous for use in fuel cells, electrolyzers employing hydrogen, ion separations, etc.
B01J 41/14 - Macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds
B01J 47/12 - Ion-exchange processes in generalApparatus therefor characterised by the use of ion-exchange material in the form of ribbons, filaments, fibres or sheets, e.g. membranes
C02F 1/469 - Treatment of water, waste water, or sewage by electrochemical methods by electrochemical separation, e.g. by electro-osmosis, electrodialysis, electrophoresis
C08F 212/32 - Monomers containing only one unsaturated aliphatic radical containing two or more rings
A membrane for separating organic solvents such as methanol and toluene is provided. A plurality methacrylate polymer brushes, e.g., composed of hydroxy ethyl methacrylate (HEMA) monomers, are grafted from a crosslinked polyimide support using Single Electron Transfer- Living Radical Polymerization (SET-LRP). The polymer brushes themselves are also crosslinked by ethylene glycol dimethacrylate (EGDMA) and/or triethylene glycol dimethacryalte (TEGDMA). These hydrophilic polymeric brush membranes demonstrate pore stiffening and yet also opening, obtaining high selectivity at reasonable permeability and reduced energy requirements for commercially relevant separations, e.g., methanol/toluene. The addition of the crosslinker prevents loss of selectivity as a result of imparting increased rigidity, enabling the membranes to be operated at higher operating pressures for increased throughput. These membranes would be beneficial for use in pharmaceutical, chemical, petroleum, food, and biotechnology industries, e.g., in the manufacture of polymethacrylic acid, the manufacture of paraxylene, etc.
B01D 53/22 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
A hollow-lid tube is provided with a body extending along a longitudinal axis and a lid configured to fit thereon. A seal is positioned within the tube to align a cavity within the body with one or more holes in the lid, and prevent a sample from escaping the cavity other than by those holes. Additionally, a membrane is positioned to separate the volume of the cavity and an environment surrounding the hollow-lid tube, for example by positioning the membrane within the hole itself, between the body and the lid, on the lid over the hole, etc. Samples to be tested or treated can be provided to a plurality of these tubes and subsequently positioned within a testing solution such that the sample and the solution each contact the membrane. Thus, simultaneous testing and/or assaying of one or more samples can be performed, greatly reducing analysis time and material costs.
In an embodiment, there is provided an apparatus. The apparatus includes an optic configured for a selected illumination application. The optic includes a first lens structure and a second lens structure. The first lens structure includes a first planar external surface configured to receive incident light, and a first internal nonplanar refractive surface opposing the first planar external surface. The second lens structure includes a second planar external surface configured to emit output light, and a second internal nonplanar refractive surface opposing the second planar external surface. The second planar external surface opposes the first planar external surface. The first internal nonplanar refractive surface and the second internal nonplanar refractive surface define a cavity. The first internal nonplanar refractive surface, the second internal nonplanar refractive surface, and the cavity are positioned between the first planar external surface and the second planar external surface. The first internal nonplanar refractive surface and the second internal nonplanar refractive surface are configured to refract received light to yield emitted light having a target output parameter corresponding to the selected illumination application.
Systems and techniques that facilitate reprogrammable federated learning are provided. In various embodiments, a server device can share a pre-trained and frozen neural network with a set of client devices. In various aspects, the server device can orchestrate reprogrammable federated learning of the pre-trained and frozen neural network among the set of client devices. In various instances, the pre-trained and frozen neural network can be positioned between at least one trainable input layer and at least one trainable output layer, and the reprogrammable federated learning can involve the at least one trainable input layer and the at least one trainable output layer, but not the pre-trained and frozen neural network, being locally adjusted by the set of client devices.
One embodiment provides a building material element. The building material element includes a three-dimensional (3D)-printed architectural element, and an integrated functional feature related to a functional element.
E04C 2/52 - Building elements of relatively thin form for the construction of parts of buildings, e.g. sheet materials, slabs, or panels characterised by the shape or structure with special adaptations for auxiliary purposes, e.g. serving for locating conduits
B33Y 80/00 - Products made by additive manufacturing
Systems and techniques that facilitate feature selection in vertical federated learning are provided. For example, one or more embodiments described herein can comprise a system, which can comprise a memory that can store computer executable components. The system can also comprise a processor, operably coupled to the memory that can execute the computer executable components stored in memory. The computer executable components can comprise an aggregator machine learning model that aggregates a plurality of embedding components from one or more local machine learning models and removes one or more embedding components based on minimizing weights at an input layer of the aggregator machine learning model.
The embodiments described herein are directed to various non-linear electrical devices in which charge flow is confined to two dimensions, so the charge flow occurs in what is called a two-dimensional system (2DS) or a two-dimensional electron system (2DES). A 2DS or 2DES can either exist in a natively two-dimensional material, such as graphene, potentially sandwiched between other materials, or in a quantum well sandwiched in semiconductor layers (e.g., a semiconductor heterostructure). A 2DS or 2DES can also be contained in certain threedimensional materials that enforce a predominantly two-dimensional charge flow. The devices exploit the non-linearity in current-voltage characteristics due to electron-electron interactions, either in the electronic ballistic or hydrodynamic transport regimes. The strength of the nonlinearity depends on the device geometry imposed on the 2DS or 2DES.
One embodiment provides a computing device. The computing device is configured to couple to a display. The computing device includes an ambient detection module configured to detect a characteristic of ambient light relative to at least a portion of a display area of the display. The computing device further includes a displayed image optimization module configured to optimize a feature of at least a portion of a displayed image based, at least in part, on the characteristic of the ambient light.
G09G 3/32 - Control arrangements or circuits, of interest only in connection with visual indicators other than cathode-ray tubes for presentation of an assembly of a number of characters, e.g. a page, by composing the assembly by combination of individual elements arranged in a matrix using controlled light sources using electroluminescent panels semiconductive, e.g. using light-emitting diodes [LED]
65.
ASSAY FOR FILTRATION OF SUSPENDED PARTICLES IN MICROPOROUS MEMBRANES
A method of assessing a membrane includes calculating fluid dynamic characteristics of at least one of a membrane and a material to be passed through the membrane, the membrane includes a plurality of rows and a plurality of teardrop structures arranged in the plurality of rows, the material includes particles; obtaining characteristic of at least one force acting on the particles of the material to be passed through the membrane due to the interaction between the particles and the membrane, the at least one force being an intermolecular force; and combining the calculated fluid dynamic characteristic and the obtained characteristics to assess the flow of the material through the membrane. In some embodiments, the teardrop structures in each row are arranged at substantially the same angle with respect to an anticipated direction of flow through the membrane.
B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
G01N 15/08 - Investigating permeability, pore volume, or surface area of porous materials
A footwear system includes an upper portion, a sole portion, and an adjustable heel. The adjustable heel includes a top section configured to the sole portion at a top surface of the top section. The top section defines a top section vertical cavity, a top section upper horizontal cavity, and a top section lower horizontal cavity. A movable top locking pin is positioned at least partially within the top section upper horizontal cavity. A bottom section is coupled to the top section and configured to extend beyond the bottom surface of the top section when extended and to be contained at least partially within the top section vertical cavity when retracted. A movable spring-loaded locking pin is positioned at least partially within a bottom section upper horizontal cavity. The spring-loaded locking pin is configured to hold the bottom section in an extended or retracted position.
A chip system is provided that includes a micropillar chip and a corresponding microwell chip. The micropillars are coated with an anchoring layer, e.g., polydopamine/polylysine/fibronectin, which anchors an amount of a hydrogel composition to the micropillars, the composition including a matrix and a concentration of cancer cells, such as those from a particular patient. Upon gelation, the composition forms a three-dimensional structure with a high cancer cell density mimicking a tumor microenvironment, e.g., allows culturing of the cancer cells in hypoxic conditions representative of the conditions at the patient's tumor. The 3D structures of composition on the micropillars are then stamped into corresponding microwells including media composed of a variety of treatments for testing against the cancer cells. The media can include immune cells, enabling co-culture of the cancer cells with the immune cells to test for immune cell-mediated cytotoxicity, as well as combinations of drug and antibody based therapies.
41 - Education, entertainment, sporting and cultural services
Goods & Services
clothing, namely, shirts, jackets and sweaters Educational services, namely, providing courses of instruction at the college level and distribution of course material in connection therewith
One embodiment provides an apparatus for fluorescence lifetime imaging (FLI). The apparatus includes a deep neural network (DNN). The DNN includes a first convolutional layer, a plurality of intermediate layers and an output layer. The first convolutional layer is configured to receive FLI input data. Each intermediate layer is configured to receive a respective intermediate input corresponding to an output of a respective prior layer. Each intermediate layer is further configured to provide a respective intermediate output related to the received respective intermediate input. The output layer is configured to provide estimated FLI output data corresponding to the received FLI input data. The DNN is trained using synthetic data.
A transition metal dichalcogenides device includes a substrate, at least one layer of boron nitride, a tungsten diselenide monolayer positioned such that the at least one layer of boron nitride at least partially encapsulates the tungsten diselenide monolayer, and a plurality of electrodes. Each of the plurality of electrodes includes gold and few-layer graphene, and the at least one layer of boron nitride includes hexagonal few-layer boron nitride. The tungsten diselenide monolayer is configured to reveal excitons when at least one of a K valley and a K′ valley of the tungsten diselenide monolayer is exposed to excitation photon energy and an external magnetic field. The excitons are giant valley-polarized Rydberg excitons in excited states ranging from 2 s to 11 s when the external magnetic field is in the range of about −17 T to about 17 T.
H01L 29/24 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only inorganic semiconductor materials not provided for in groups , , or
In an embodiment, there is provided a full tomographic data estimation circuitry. The full tomographic data estimation circuitry includes a tomographic data preprocessing circuitry, a trained score model circuitry, a parallel subset estimation circuitry, and a subset assembly circuitry. The tomographic data preprocessing circuitry is configured to divide an input sparse tomographic dataset into a number, N, input sparse tomographic data subsets. The parallel subset estimation circuitry is configured to estimate a respective estimated full tomographic data subset for each input sparse tomographic data subset in the input sparse tomographic dataset. The estimating is performed in parallel. The subset assembly circuitry is configured to combine the N estimated full tomographic data subsets to form an estimated full tomographic dataset.
G01N 23/04 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by transmitting the radiation through the material and forming images of the material
G03B 42/00 - Obtaining records using waves other than optical wavesVisualisation of such records by using optical means
The electrochemical energy conversion system of the present disclosure includes an anode, a cathode, and an ion exchange membrane including a polymer having an aromatic polymer chain and an alkylated substrate including an alkyl chain, and at least one ionic group. The alkylated substrate is bound to at least one aromatic group in the polymer chain via Friedel-Crafts alkylation of the at least one aromatic group. The alkylation reaction utilizes a haloalkylated tertiary alcohol or a haloalkylated alkene as a precursor. In the presence of an acid catalyst, a carbocation is generated in the precursor which reacts with the aromatic rings of the polymer chain. The at least one ionic group is then replaced with a desired cationic or anionic group using a substitution reaction. The membranes exhibit advantageous stability achieved through a simplified and scalable reaction scheme.
H01M 8/1032 - Polymeric electrolyte materials characterised by the chemical structure of the main chain of the ion-conducting polymer having sulfur, e.g. sulfonated-polyethersulfones [S-PES]
H01M 8/1072 - Polymeric electrolyte materials characterised by the manufacturing processes by chemical reactions, e.g. insitu polymerisation or insitu crosslinking
73.
PROGRAMMABLE AND TUNABLE CYLINDRICAL DEFLECTOR ANALYZERS
An electrostatic analyzer includes a cylindrical body having an inner cylinder and an outer cylinder that are coaxial with one another along a longitudinal axis of the cylindrical body. An inner cylindrical electrode is positioned on an exterior face of the inner cylinder. An outer cylindrical electrode is positioned on an interior face of the outer cylinder. A first azimuthal electrode positioned on a face of a first azimuthal plane that passes through the longitudinal axis. A second azimuthal electrode is positioned on a face of a second azimuthal plane that passes through the longitudinal axis. A first end electrode is positioned on a first end face of the cylindrical body. A second end electrode is positioned on a second end face of the cylindrical body.
Embodiments of the invention relate to a novel class of polymers with superior mechanical properties and chemical stability, as compared to known polymers. These polymers are particularly well suited for use in anion exchange membranes (AEMs), including those employed in fuel cells. Novel methods for the manufacture of these polymers are also described.
C08G 61/02 - Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes
A01N 29/00 - Biocides, pest repellants or attractants, or plant growth regulators containing halogenated hydrocarbons
C08G 10/00 - Condensation polymers of aldehydes or ketones with aromatic hydrocarbons or halogenated aromatic hydrocarbons only
C09D 5/14 - Paints containing biocides, e.g. fungicides, insecticides or pesticides
C09D 165/00 - Coating compositions based on macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chainCoating compositions based on derivatives of such polymers
C25B 13/08 - DiaphragmsSpacing elements characterised by the material based on organic materials
H01M 8/1004 - Fuel cells with solid electrolytes characterised by membrane-electrode assemblies [MEA]
H01M 8/1072 - Polymeric electrolyte materials characterised by the manufacturing processes by chemical reactions, e.g. insitu polymerisation or insitu crosslinking
A fixation device includes a body having a first axial end and a second axial end defining a longitudinal axis. The body has a longitudinal bore therein, and a longitudinal slot in a first side of the body extending laterally to the bore. A mounting bracket is connected to the first axial end at a second side opposite the slot and extends outward therefrom. The mounting bracket is configured to be mounted to a first structure. A support member is retained in the bore and is configured to move longitudinally in the bore. The support member protrudes outward from the first side of the body to support a second structure a longitudinal distance from the first structure. A lead screw engages a threaded hole in the base whereby rotation of the lead screw moves the support member to adjust the longitudinal distance between the first and second structures.
A thermoresponsive smart window is provided. The window includes a first windowpane that is positioned at a first side of the window, a second windowpane that is positioned at a second side of the window opposite the first side, and a gap between the first windowpane and the second windowpane. A thermoresponsive liquid mixture is within the gap. The thermoresponsive liquid mixture is configured to display a phase separation at a lower critical solution temperature such that the window is configured to dynamically and passively switch between a transparent state and a translucent state.
G02F 1/01 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour
G02F 1/00 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics
B32B 7/02 - Physical, chemical or physicochemical properties
E06B 9/24 - Screens or other constructions affording protection against light, especially against sunshineSimilar screens for privacy or appearance
A wind turbine includes a frame that has a top portion and a bottom portion defining a longitudinal axis of the wind turbine. A cylindrical core is substantially centrally located in the frame along the longitudinal axis and is configured to rotate about the longitudinal axis. A pair of airfoils is connected to the cylindrical core and is configured to collect incident wind to rotate the cylindrical core. The airfoils are diametrically opposed to each other and wrap around the cylindrical core along the longitudinal axis in a double-helical shape thereby forming a wind collection side on a first longitudinal side and a wind drag side on a second longitudinal side. A wind deflector is connected to the frame and is configured to divert wind incident on the wind drag side to the wind collection side for collection by the pair of airfoils.
F03D 3/04 - Wind motors with rotation axis substantially perpendicular to the air flow entering the rotor having stationary wind-guiding means, e.g. with shrouds or channels
A photodiode structure including a silicon substrate, an oxide layer on the silicon substrate, a silicon on insulator region on the oxide layer, a germanium absorption region, a silicon nitride waveguide, a cathode region, and an anode region is provided. The germanium absorption region is at least partially disposed in a recess of the silicon on insulator region. The germanium absorption region includes a top surface having a first width and a bottom surface having a second width, the first width being greater than the second width. The cathode region is formed at a first side of the germanium absorption region, and the anode region is formed at a second side of the germanium absorption region that is opposite the first side.
H01L 31/107 - Devices sensitive to infrared, visible or ultraviolet radiation characterised by only one potential barrier or surface barrier the potential barrier working in avalanche mode, e.g. avalanche photodiode
G02B 6/10 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type
H01L 31/0232 - Optical elements or arrangements associated with the device
H01L 31/0352 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by their semiconductor bodies characterised by their shape or by the shapes, relative sizes or disposition of the semiconductor regions
H01L 31/18 - Processes or apparatus specially adapted for the manufacture or treatment of these devices or of parts thereof
One embodiment provides a lens structure. The lens structure includes a backend. The backend includes a backend back surface and a backend front surface. The backend is configured to receive a luminous flux from a light source and to redirect the received luminous flux onto a lens. The redirected luminous flux is configured to increase a luminous efficacy.
Systems and methods for reducing temporal light artifacts ("TLAs") occurrence during light source dimming operations are provided. The system includes a dimmer, a light source, and a driving circuit. The driving circuit is configured to receive a signal from the dimmer and perform a dimming curve algorithm on the signal to drive the light source with a non-linear dimming curve such that a light output of the light source over a dimming duration has no TLAs detectable by a human observing the light output. The method includes receiving, at a driving circuit, a signal from a dimmer; performing a dimming curve algorithm on the signal to generate a non-linear dimming curve; and driving a light source with the non¬ linear dimming curve to dim a light output of the light source such that the light output over a dimming duration has no TLAs detectable by a human observing the light output.
H05B 45/59 - Circuit arrangements for operating light-emitting diodes [LED] responsive to malfunctions or undesirable behaviour of LEDsCircuit arrangements for operating light-emitting diodes [LED] responsive to LED lifeProtective circuits for reducing or suppressing flicker or glow effects
H05B 45/10 - Controlling the intensity of the light
81.
3D PRINTED INTEGRATED THERMAL MANAGEMENT AND LIGHT TRANSFER STRUCTURES
One embodiment provides a luminaire. The luminaire includes a light transfer structure, and a thermal management structure. The light transfer structure is configured to receive light from at least one light emitting diode (LED). The thermal management structure is configured to manage a thermal energy of the at least one LED. The light transfer structure and the thermal management structure are formed during a same three-dimensional (3D) printing process.
F21V 29/83 - Cooling arrangements characterised by passive heat-dissipating elements, e.g. heat-sinks the elements having apertures, ducts or channels, e.g. heat radiation holes
B33Y 80/00 - Products made by additive manufacturing
F21V 29/503 - Cooling arrangements characterised by the adaptation for cooling of specific components of light sources
82.
NASAL SPRAY USING PENTOSAN POLYSULFATE AND MUCOPOLYSACCHARIDE POLYSULFATE FOR COVID-19 PREVENTION AND TREATMENT
Prophylaxis and treatment of patients susceptible to infection by coronaviruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is achieved using compositions including one or more inhibitors including sulfated glycans and/or highly negative charged compounds. The inhibitors bind to wild-type and variant spike glycoproteins (S-proteins or SGPs) of SARS-CoV-2, inhibiting fusion, entry, and infection of a host cell. The inhibitors can include pentosan polysulfate (PPS), mucopolysaccharide polysulfate (MPS), sulfated lactobionic acid, sulodexide, a defibrotide, 4-t-butylcalix[X] arene-p-sulfonic acid, or combinations thereof. The presence of additional sulfo groups in PPS and MPS contribute to the improved inhibitory activity of compositions with those sulfated glycans against COVID-19 compared with compositions containing heparin alone. The compositions can be formulated for nasal delivery to a patient, enabling a simplified treatment regimen effective against an ever increasing number of SARS-CoV-2 variants of concern.
In one embodiment, there is provided a dynamic multi-source image reconstruction apparatus. The apparatus includes a first reconstruction stage, a second reconstruction stage, and a refinement stage. The first reconstruction stage is configured to receive an input data set including a group of data frames. Each data frame corresponds to a respective time step. Each data frame includes a number of projection data sets. Each projection data set corresponds to a respective source-detector pair of a stationary multi-source tomography system. The first reconstruction stage is further configured to reconstruct a first intermediate image based, at least in part, on the group of data frames. The second reconstruction stage is configured to receive a selected data frame and to reconstruct a second intermediate image with a constraint of the first intermediate image as prior. The refinement stage is configured to refine the second intermediate image to produce a three-dimensional output image.
A computer-implemented method, a computer program product, and a computer system for automatic adaptive client selection in federated learning. A server sends parameters of a machine learning model to all of clients, where all of the clients compute respective gradients using the parameters. The server receives sketches of the respective gradients, where the sketches are computed by all of the clients. The server uses the sketches to compute similarity between all of the clients and clusters the all of the clients based on the similarity. The server optimizes a number of client clusters and a dimension of the sketches, subject to a constraint of memory consumption, a constraint of communication overhead, and a performance metric. The server determines a subset of the clients that send the respective gradients, by selecting the clients from the client clusters. The server aggregates the respective gradients sent by the subset of the clients.
A composition is orally or topically administered to a patient susceptible to infection by an orthopoxvirus such as monkeypox (mpox). The composition includes inhibitors configured to bind to orthopoxvirus envelope proteins, e.g., MPXV A29 from mpox. The inhibitors can include sulfated polysaccharides or glycans such as heparin, chondroitin sulfate A, chondroitin sulfate B (dermatan sulfate), chondroitin sulfate C, chondroitin sulfate D, chondroitin sulfate E, pentosan polysulfate, mucopolysaccharide polysulfate, or combinations thereof. Binding of the composition to the envelope proteins inhibits the interaction between the virions and heparan sulfate proteoglycans (HSPG) and thus the ability of the virions to enter the host cell. Limiting this transport across the host cell membrane inhibits initial viral infection, as well as limits spread of that infection from cell to cell even in the event viral infection is initially achieved, providing significantly improved patient treatment and recovery outcomes relating to orthopoxvirus infections such as mpox.
A CT apparatus in which the x-ray source is coupled to a source robotic arm and the detector is coupled to a detector robotic arm. A motion correction module utilizes a locally linear embedding motion correction algorithm to estimate the geometry-describing parameters associated with the positions of the source and detector and the angle of the detector. These estimates are used to reconstruct the image data and produce corrected images with fewer errors resulting from patient movement, misalignments, and coordination issues in the system.
A decision network for moral decision-making includes a trained group artificial neural network (ANN), a trained individual ANN, and a fusion block. The trained group ANN is configured to receive a selected input vector and to produce an estimated en group output based, at least in part, on the selected input vector. The trained group ANN is trained based, at least in part, on group training data including a plurality of group input vectors and corresponding training group outputs. Each group input vector includes a plurality of scenario parameters. The trained individual ANN is configured to receive the selected input vector and to produce an estimated individual output based, at least in part, on the selected input vector. The trained individual ANN is trained after the trained group ANN is trained.
A plant stalk decorticator includes a pair of feed rollers arranged abutting one another along a substantially horizontal axis with a line of contact therebetween. A splitting wedge is positioned at least partially below the pair of feed rollers and aligned along a substantially vertical axis that is substantially centrally located in the line of contact between the pair of feed rollers, the splitting wedge is configured to split a plant stalk fed from the pair of feed rollers into two plant fiber bark sections. Symmetrical pairs of vertically stacked peeling rollers are positioned below the pair of feed rollers and laterally from either side of the substantially vertical axis. Each of the pairs of peeling rollers are configured to receive a respective one of the plant fiber bark sections from the splitting wedge and separate the plant fiber bark section from the respective other one of the plant fiber bark sections.
A system for few-view computed tomography (CT) image reconstruction is described. The system includes a preprocessing module, a first generator network, and a discriminator network. The preprocessing module is configured to apply a ramp filter to an input sinogram to yield a filtered sinogram. The first generator network is configured to receive the filtered sinogram, to learn a filtered back-projection operation and to provide a first reconstructed image as output. The first reconstructed image corresponds to the input sinogram. The discriminator network is configured to determine whether a received image corresponds to the first reconstructed image or a corresponding ground truth image. The generator network and the discriminator network correspond to a Wasserstein generative adversarial network (WGAN). The WGAN is optimized using an objective function based, at least in part, on a Wasserstein distance and based, at least in part, on a gradient penalty.
The present disclosure relates to an apparatus for enhancing contrast sensitivity and resolution in a grating interferometer by machine learning, which can improve both image contrast sensitivity and spatial resolution in a grating interferometer by machine learning, the apparatus including: an image acquisition unit; a numerical phantom generation unit, a convolution layer generation unit to extract features from input data; an activation function application calculation unit that can apply a rectified linear activation function to an output value of the convolution calculation to perform smooth repetitive machine learning; a CNN repetitive machine learning unit that corrects a convolution calculation factor while repeatedly performing forward propagation and backward propagation processes; and an image matching output unit that matches and outputs features extracted by repetitive machine learning of the CNN repetitive machine learning unit.
G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
G06V 10/75 - Organisation of the matching processes, e.g. simultaneous or sequential comparisons of image or video featuresCoarse-fine approaches, e.g. multi-scale approachesImage or video pattern matchingProximity measures in feature spaces using context analysisSelection of dictionaries
G02B 6/293 - Optical coupling means having data bus means, i.e. plural waveguides interconnected and providing an inherently bidirectional system by mixing and splitting signals with wavelength selective means
91.
METHODS OF PREDICTING BONE FRACTURE RISK IN TYPE 2 DIABETES PATIENTS
A method of predicting bone fracture risk in a type 2 diabetes (“T2D”) patient includes: obtaining a plurality of averaged glycated hemoglobin (“HbA1c”) values for a plurality of T2D subjects over an observational period; binning the plurality of averaged HbA1c values into two predetermined categories; obtaining a plurality of total fracture incidences for the plurality of T2D subjects over a follow-up period; performing a plurality of linear regression model correlations between the binned HbA1c values and the plurality of total fracture incidences to determine a bone fracture rate prediction model; obtaining a measurement of an HbA1c value of the T2D patient; and analyzing the HbA1c value of the T2D patient with the bone fracture rate prediction model to determine the T2D patient's risk of bone fracture for a future period.
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
In one embodiment, there is provided a magnetic resonance (MR) subsystem for magnetic resonance imaging (MRI). The MR subsystem includes a first magnet-coil assembly and a second magnet-coil assembly. The first magnet-coil assembly includes a first magnet structure and a first gradient coil. The second magnet-coil assembly includes a second magnet structure and a second gradient coil. The first magnet-coil assembly and the second magnet-coil assembly are separated by a gap. The gap is configured to facilitate transmission of an x-ray beam from an x-ray source to an x-ray detector. The x-ray source and the x-ray detector are included in a computed tomography (CT) subsystem.
In an embodiment, there is provided a self-supervised representation learning (SSRL) circuitry. The SSRL circuitry includes a normalizer circuitry, and a loss function circuitry. The normalizer circuitry is configured to receive a number, T, batches of embedding features. Each batch includes a number, N, embedding features. The number N corresponds to a number of input samples in a training batch. The number T corresponds to a number of respective transformed batches. Each transformed batch corresponds to a respective transformation of the training batch. The embedding features may be related to the transformed batches. Each embedding feature has a dimension, D, and each embedding feature element corresponds to a respective feature variable. The normalizer circuitry is further configured to normalize each feature variable of a selected batch, using a zero mean and a unit standard deviation of the selected batch. A loss function circuitry is configured to determine a loss function based, at least in part, on a factorizable mixed moment of a plurality of normalized feature variables. The mixed moment is of order K. K is less than or equal to the embedding feature dimension D.
nn tails, e.g., for purification of mRNA production and commercialization, enabling fast, efficient, and continuous production of mRNA vaccines such as those against coronaviruses, e.g., SARS-CoV-2.
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
Embodiments of the invention relate generally to electrospun fibers and, more particularly, to the controlled release of an active pharmaceutical ingredient (API) from electrospun fiber scaffolds (EFSs).
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
D01F 6/62 - Monocomponent man-made filaments or the like of synthetic polymersManufacture thereof from homopolycondensation products from polyesters
D01F 6/68 - Monocomponent man-made filaments or the like of synthetic polymersManufacture thereof from homopolycondensation products from polyaminoacids or polypeptides
D02J 13/00 - Heating or cooling the yarn, thread, cord, rope, or the like, not specific to any one of the processes provided for in this subclass
D04H 1/728 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning
96.
SELF-SUPERVISED REPRESENTATION LEARNING WITH MULTI-SEGMENTAL INFORMATIONAL CODING
In one embodiment, there is provided a self-supervised representation learning (SSRL) circuitry. The SSRL circuitry includes a transformer circuitry configured to receive input data. The input data includes an input batch containing a number, N, of input data sets. The transformer circuitry is configured to transform the input batch into a plurality of training batches. Each training batch contains the number N training data sets. The SSRL circuitry further includes for each training batch: a respective encoder circuitry, a respective projector circuitry, and a respective partitioning circuitry. The respective encoder circuitry is configured to encode each training data set into a respective representation feature. The respective projector circuitry is configured to map each representation feature into an embedding space as a respective embedding feature vector.
A liquid material including a polysaccharide is manufactured by creating a mixture of polysaccharides and an aqueous solvent or an aqueous cosolvent with organic solvents at a temperature at which gelation does not occur. The mixture is also irradiated at this lower temperature, such as with ultrasound waves in combination with stirring and/or bubbling of inert gases. to apply ultrasound to a mixture of. Compared with conventional reactions with low concentration solutions, the product yield and advantageous mechanical properties are significantly increased. Depolymerization (decomposition, disassembly) of polysaccharide in the liquid material does not occur to any substantial degree, and the molecular structure of the polysaccharide is maintained. Further, the liquid material does not gel even when the temperature is raised, and thus, its fluidity is maintained, despite polysaccharides being maintained at a high concentration. The liquid material is applicable to myriad industries, including pharmaceuticals and health foods.
C08J 3/28 - Treatment by wave energy or particle radiation
C08J 3/03 - Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
A23L 33/125 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing carbohydrate syrupsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugarsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugar alcoholsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing starch hydrolysates
The method provides for analyzing input and output connections of layers of a received neural network model configured for vertical federated learning. An undirected graph of nodes is generated in which a node having two or more child nodes includes an aggregation operation, based on the analysis of the model in which a model output corresponds to a node of the graph. A layer of the model is identified in which a sum of lower layer outputs are computed. The identified model layer is partitioned into a first part applied respectively to the multiple entities and a second part applied as an aggregator of the output of the first part. The aggregation operation is performed between pairs of lower layer outputs, and multiple forward and backward passes of the neural network model are performed that include secure aggregation and maintain model partitioning in forward and backward passes.
An output layer is removed from a pre-trained neural network model and a neural capacitance probe unit with multiple layers is incorporated on top of one or more bottom layers of the pre-trained neural network model. The neural capacitance probe unit is randomly initialized and a modified neural network model is trained by fine-tuning the one or more bottom layers on a target dataset for a maximum number of epochs, the modified neural network model comprising the neural capacitance probe unit incorporated with multiple layers on top of the one or more bottom layers of the pre-trained neural network model. An adjacency matrix is obtained from the initialized neural capacitance probe unit and a neural capacitance metric is computed using the adjacency matrix. An active model is selected using the neural capacitance metric and a machine learning system is configured using the active model.
G01R 27/26 - Measuring inductance or capacitanceMeasuring quality factor, e.g. by using the resonance methodMeasuring loss factorMeasuring dielectric constants
100.
ASYMMETRIC LIGHT TRANSMISSION SURFACES FOR ENHANCING EFFICIENCY OF SOLAR CONCENTRATORS
A luminescent solar concentrator including a light propagation device, one or more photovoltaic cells, and one or more waveguides is provided. The light propagation device includes a plurality of nanostructures configured to permit preferential propagation of a wavelength range of light in one direction. The one or more photovoltaic cells are positioned adjacent an end of the light propagation device. The one or more waveguides are configured to guide light toward the one or more photovoltaic cells via total internal reflection within the luminescent solar concentrator.
H01L 31/055 - Optical elements directly associated or integrated with the PV cell, e.g. light-reflecting means or light-concentrating means where light is absorbed and re-emitted at a different wavelength by the optical element directly associated or integrated with the PV cell, e.g. by using luminescent material, fluorescent concentrators or up-conversion arrangements
