A network of microfibers are fabricated with a core-shell construction from sustainable materials, where the core includes a phase-change material, such as coconut oil, and the shell includes a biomass, such as cellulose. The microfibers are made via a wet-wet electrospinning process utilizing a coaxial spinneret with an inner conduit and an outer conduit. The biomass and the phase-change material are coaxially extruded into a coagulation bath including a mixture of ethanol and water. The collected microfibers exhibit a beaded structure of PCM aggregates and biomass connecting regions between the aggregates and are effective to aid in the thermoregulation of the immediate environment surrounding the network. The microfibers are suitable for use in a variety of sustainable products such as wearable thermoregulating textiles, wall/ceiling panels, insulation, packaging material, and more.
D01F 1/10 - Autres agents modifiant les propriétés de ces filaments
D01F 2/00 - Filaments, ou similaires, artificiels, à un seul composant, formés de cellulose ou de dérivés de la celluloseLeur fabrication
D04H 1/413 - Non-tissés formés uniquement ou principalement de fibres coupées ou autres fibres similaires relativement courtes à partir de voiles ou couches composés de fibres ne possédant pas des propriétés cohésives réelles ou potentielles contenant des granulés autres que les substances absorbantes
D04H 1/4382 - Fibres obtenues par étirage de film réticuléFibres compositesFibres mixtesFibres ultrafinesFibres pour cuir artificiel
D04H 1/4391 - Non-tissés formés uniquement ou principalement de fibres coupées ou autres fibres similaires relativement courtes à partir de voiles ou couches composés de fibres ne possédant pas des propriétés cohésives réelles ou potentielles caractérisés par l'emploi de certaines sortes de fibres dans la mesure où cet emploi n'a pas d'influence prépondérante sur la consolidation du voile caractérisés par la forme des fibres
D04H 1/728 - Non-tissés formés uniquement ou principalement de fibres coupées ou autres fibres similaires relativement courtes caractérisés par la méthode de formation des voiles ou couches, p. ex. par la réorientation des fibres les fibres étant disposées au hasard par électrofilage
2.
NANOFIBROUS MATERIALS FOR PASSIVE THERMAL CONTROL ON EARTH AND IN SPACE
Nanofibrous materials and their fabrication by electrospinning are disclosed for passive temperature control on earth and in outer space. The materials combine high solar reflectivity with high thermal emittance in the infrared region, including in the long wavelength atmospheric window region between 8 μm and 13 μm. The materials include nanofibrous PTFE/PEO and silica materials. The physical properties of the materials are suitable for extraterrestrial as well as terrestrial applications.
D01D 5/00 - Formation des filaments, fils ou similaires
D01F 1/10 - Autres agents modifiant les propriétés de ces filaments
D01F 6/66 - Filaments, ou similaires, faits par l’homme, à un seul composant, formés de polymères synthétiquesLeur fabrication à partir de produits d'homopolycondensation à partir de polyéthers
3.
METHODS AND SYSTEMS FOR COMPOSITE TOPOLOGICAL DESIGN
A method for topological design optimization in which a number of objective scattering(S) parameters are initially decomposed into a product of smaller devices (primitives). Each of the primitives are optimized in parallel using inverse design; and the topologies of the smaller devices are then composited into a final device design region, in which the final device design region is an initialization of a final optimization, advantageously saving computation time. According to at least one embodiment, the herein described optimization procedure can be utilized in order to design a composite power combiner that is essentially phase-insensitive.
G01D 5/26 - Moyens mécaniques pour le transfert de la grandeur de sortie d'un organe sensibleMoyens pour convertir la grandeur de sortie d'un organe sensible en une autre variable, lorsque la forme ou la nature de l'organe sensible n'imposent pas un moyen de conversion déterminéTransducteurs non spécialement adaptés à une variable particulière utilisant des moyens optiques, c.-à-d. utilisant de la lumière infrarouge, visible ou ultraviolette
G06N 3/067 - Réalisation physique, c.-à-d. mise en œuvre matérielle de réseaux neuronaux, de neurones ou de parties de neurone utilisant des moyens optiques
H04J 14/02 - Systèmes multiplex à division de longueur d'onde
G01F 1/00 - Mesure du débit volumétrique ou du débit massique d'un fluide ou d'un matériau solide fluent, dans laquelle le fluide passe à travers un compteur par un écoulement continu
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Business research services in the field of economics, entrepreneurship, information systems, social, cognitive and computer networks, management of business production and operations, applied manufacturing and business finance information Education services in the nature of courses at the university level Architectural research; Scientific research; Engineering research
An aircraft lift enhancement system is provided. The aircraft lift enhancement system includes an airfoil and at least one rotor. The airfoil includes a leading edge and a trailing edge defining a longitudinal axis of the airfoil, and a proximal end and a distal end defining a length of the airfoil. The at least one rotor is positioned a first distance substantially behind the trailing edge of the airfoil as measured along the longitudinal axis and a second distance substantially vertically below a lower surface of the airfoil. The at least one rotor includes a hub and a plurality of aerodynamic blades extending outwards from the hub a radial distance R and configured to rotate in a substantially horizontal plane around a center point of the rotor.
A separation substrate is modified with primary amine ligands, e.g., 2-aminoethyl methacrylate hydrochloride (AEMA), for continuous electrostatic purification of mRNA vaccines from in vitro transcription (IVT) bioreactor effluent. Modified membrane surface charges are responsive to changes in pH, as are charges associated with the mRNA and impurities in the sample. By reducing the pH of mobile phases in contact with the membrane below the isoelectric point (pl) of the peptide impurities in the sample, the peptides become net positive while the mRNA products remain net negative, allowing the mRNA product to bind while the peptides are eluted away. Salt solutions to increase the ionic strength and cationic species to increase the N/P ratio of the mobile phase/membrane further purify the mRNA from other nucleic acid species, e.g., pDNA, dsRNA. Raising mobile phase pH above the pl of the membrane, e.g., about 8.5, can then elute purified mRNA product.
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
B01D 15/36 - Adsorption sélective, p. ex. chromatographie caractérisée par le mécanisme de séparation impliquant une interaction ionique, p. ex. échange d'ions, paire d'ions, suppression d'ions ou exclusion d'ions
C08F 22/00 - Homopolymères ou copolymères de composés contenant un ou plusieurs radicaux aliphatiques non saturés, chaque radical ne contenant qu'une seule liaison double carbone-carbone, l'un au moins étant terminé par un radical carboxyle et contenant au moins un autre radical carboxyle dans la moléculeLeurs sels, anhydrides, esters, amides, imides ou nitriles
7.
METHODS FOR RECYCLING AND SEQUESTERING FLUORIDE SALT WASTE STREAMS
A method of treating molten salt reactor waste is disclosed, the method including solubility separations of lithium fluoride salts and cesium fluoride salts from other fluoride salts, recycling of lithium, sodium and potassium salts, and sequestration of radioactive waste in metal halide perovskite minerals.
An affinity membrane separator is provided that includes a separation substrate with a plurality of peptide ligands positioned thereon. The peptide ligands preferentially bind to one of a nucleic acid product and a waste nucleic acid product, e.g., produced by a mRNA synthesis bioreactor. The peptide ligands include fewer than 20 residues and at least one defined secondary structure, and have a global charge greater than about 1 and at least one lysine, arginine, or glutamine residue in order to preferentially bind ds-RNA relative to ss-RNA, or a global charge less than about 0 and at least one serine or asparagine residue in order to preferentially bind ss-RNA relative to ds-RNA. Peptide ligands can advantageously bind to ds-RNA byproducts from the production of ss-RNA vaccines, e.g., against SARS-CoV-2, while allowing the ss-RNA vaccines themselves to pass through the separator, providing an efficient system for production of purified ss-RNA vaccine products.
An intermediate global lower-level machine learning model is generated by executing federated learning model training using data from an identified first set of lower-level non-Byzantine client computers which are characterized as being non-Byzantine for the lower-level system. A global lower-level machine learning model is generated by executing the federated learning model training using data from an identified second lower-level set of non-Byzantine client computers which are characterized as being non-Byzantine for the lower-level system. An intermediate global upper-level machine learning model is generated by executing the federated learning model training using data from an identified first upper-level set of non-Byzantine client computers which are characterized as being non-Byzantine for an upper-level system. A global upper-level machine learning model is generated by executing the federated learning model training using data from a second upper-level set of client computers which are characterized as being non-Byzantine for the upper-level system.
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Business research services in the field of economics, entrepreneurship, information systems, social, cognitive and computer networks, management of business production and operations, applied manufacturing and business finance information Education services in the nature of courses at the university level Architectural research; Scientific research; Engineering research
Therapeutic agents such as mRNA fragments are delivered to a patient to treat peripheral nerve system injuries via functionalized fiber networks. The fiber networks are electrospun from poly(L-lactic acid), producing a hollow conduit of aligned fibers. The networks are functionalized with an anionic layer, e.g., dextran sulfate sodium salt (DSS), poly(3,4-dihydroxy-L-phenylalanine) (pDOPA). mRNA complexes including a cationic liposomal transfection portion and an mRNA portion, such as Ψ-modified mRNA encoding neurotrophin-3 (NT-3), are immobilized thereon. The fiber networks are positioned to bridge a peripheral nerve gap in the patient. These networks upregulate secretion of expressed oligopeptides, e.g., NT-3, by surrounding cells, and thus enhance neurite outgrowth. The networks serve as versatile non-viral mRNA delivery platforms. The mRNA transcript, gene delivery vehicle, and surface coatings can be modified to regulate different desired proteins, optimize transfection efficiency, enable targeted delivery, and tune loading efficiency and release kinetics.
C12N 15/88 - Introduction de matériel génétique étranger utilisant des procédés non prévus ailleurs, p. ex. co-transformation utilisant la micro-encapsulation, p. ex. utilisant des vésicules liposomiques
12.
BIOMIMETIC NANO-COMPOSITE SCAFFOLD FOR ENHANCED BONE HEALING AND FRACTURE REPAIR
Provided is a method of mineralizing tissue, including placing within a body of a subject a substance, wherein the substance includes osteopontin and osteocalcin. Also provided is a tissue mineralization-promoting substance including osteopontin and osteocalcin, and an article for promoting tissue mineralization, including an implant which may be an orthopedic implant or an endosseous implant, and a substance disposed on a surface of the implant including osteopontin, and osteocalcin. A method of making a tissue mineralization-promoting substance, including combining osteopontin and osteocalcin, is also provided. Other features, including calcium phosphate, type-I collagen, mesenchymal stem cells, and growth factors, are also provided.
A61L 27/26 - Mélanges de matériaux macromoléculaires
A61F 13/00 - Bandages ou pansementsGarnitures absorbantes
A61L 27/12 - Matériaux contenant du phosphore, p. ex. apatite
A61L 27/46 - Matériaux composites, c.-à-d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice macromoléculaire avec des charges inorganiques contenant du phosphore
A61L 27/54 - Matériaux biologiquement actifs, p. ex. substances thérapeutiques
13.
METHOD FOR PRODUCING SULFATED POLYSACCHARIDE AND METHOD FOR PRODUCING PAPS
The invention provides a method for producing a sulfated polysaccharide by generating a sulfated polysaccharide by incorporating, in a reaction solution in the presence of ATP or an ATP source, a sulfate ion source, and N-sulfoheparosan, a transformant (a) of a bacterium of the genus Corynebacterium, comprising at least a gene encoding an ATP sulfurylase and a gene encoding an APS kinase, and at least one selected from a transformant (b) of a microorganism belonging to prokaryotes, comprising at least a gene encoding a C5-epimerase, a transformant (c) of a microorganism belonging to prokaryotes, comprising at least a gene encoding a 2-O-sulfotransferase, a transformant (d) of a microorganism belonging to prokaryotes, comprising at least a gene encoding a 6-O-sulfotransferase, and a transformant (e) of a microorganism belonging to prokaryotes, comprising at least a gene encoding a 3-O-sulfotransferase.
Inhibitors are provided for targeting γ-secretase to reduce amyloid load as a viable strategy in Alzheimer's disease treatment and drug discovery. γ-secretase has been shown to cleave amyloid precursor protein, causing an increase in the extracellular concentration of amyloid-β peptides. This extracellular concentration increase can lead to a build-up of amyloid plaques in patients and associated health complications for them. The inhibitors bind adjacent the transmembrane domain of amyloid precursor protein through both covalent and non-covalent interactions. These interactions inhibit the ability of γ-secretase to cleave the amyloid precursor protein, halting the build-up of extracellular amyloid plaques. The inhibitors exhibit specificity for amyloid precursor proteins, reducing concerns of potential off-target effects.
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
A61K 38/00 - Préparations médicinales contenant des peptides
C12N 9/64 - Protéinases provenant de tissu animal, p. ex. rennine
15.
ENHANCING CONTRAST SENSITIVITY AND RESOLUTION IN A GRATING INTERFEROMETER BY MACHINE LEARNING
The present disclosure relates to an apparatus for enhancing contrast sensitivity and resolution in a grating interferometer by machine learning, which can improve both image contrast sensitivity and spatial resolution in a grating interferometer by machine learning, the apparatus including: a grating interferometer image acquisition unit that acquires a relatively high resolution image and a relatively high sensitivity image by linearly moving the position of a sample from the symmetrical grating interferometer; a numerical phantom generation unit that generates a numerical phantom for performing machine learning; a convolution layer generation unit that performs calculation processing of a convolutional neural network to extract features from input data; an activation function application calculation unit that can apply a ReLu (Rectified linear unit) activation function to an output value of the convolution calculation to perform smooth repetitive machine learning; a CNN repetitive machine learning unit that corrects a convolution calculation factor while repeatedly performing forward propagation and backward propagation processes; and an image matching output unit that matches and outputs features extracted by repetitive machine learning of the CNN repetitive machine learning unit.
G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
G02B 6/293 - Moyens de couplage optique ayant des bus de données, c.-à-d. plusieurs guides d'ondes interconnectés et assurant un système bidirectionnel par nature en mélangeant et divisant les signaux avec des moyens de sélection de la longueur d'onde
G06V 10/75 - Organisation de procédés de l’appariement, p. ex. comparaisons simultanées ou séquentielles des caractéristiques d’images ou de vidéosApproches-approximative-fine, p. ex. approches multi-échellesAppariement de motifs d’image ou de vidéoMesures de proximité dans les espaces de caractéristiques utilisant l’analyse de contexteSélection des dictionnaires
16.
MOTION CORRECTION WITH LOCALLY LINEAR EMBEDDING FOR HELICAL PHOTON-COUNTING CT
A method of motion correction image reconstruction for photon-counting CT images includes scanning a subject via a photon-counting CT scanner device to obtain measured projection data; performing, via motion correction circuitry of the motion correction system, a LLE motion correction algorithm on the measured projection data to obtain motion correction data; generating, via reconstruction circuitry of the motion correction system, reconstructed image data from the motion correction data; and outputting corrected image data based, at least in part, on the reconstructed image data. A binary bad pixel mask is applied to exclude contributions from the bad pixels to the measured projection data. An unreliable volume mask is applied to exclude contributions from X-ray beams that passed through unreliable portions of the reconstructed image data. A virtual static object removal algorithm is performed to remove a static object from the measured projection data.
Electro-optic modulators comprising cascaded apodized Bragg gratings for use as slow- light modulators. At least one waveguide arm of the modulator includes a first section comprising an outward apodized grating and a second section connected in series comprising an inward apodized grating. Some embodiments include one or more heaters for tuning the central operational wavelength of the modulator.
G02B 6/42 - Couplage de guides de lumière avec des éléments opto-électroniques
G02F 1/035 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p. ex. commutation, ouverture de porte ou modulationOptique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur basés sur des céramiques ou des cristaux électro-optiques, p. ex. produisant un effet Pockels ou un effet Kerr dans une structure de guide d'ondes optique
18.
ENHANCING IN-CONTEXT LEARNING WITH FOUNDATION MODELS VIA FEW-SHOT LINEAR PROBE CALIBRATION
Aspects provide in-context learning with calibration for a foundation model. A validation prompt including one or more demonstration samples and an evaluation example is received and an output probability generated using the foundation model and the validation prompt. A calibration loss is computed based on the output probability and a set of calibration parameters. The set of calibration parameters is updated based on the calibration loss using an optimization algorithm. An inferencing operation is performed using the updated calibration parameters.
A bead-based assay system and methods for screening molecule inhibitors of protein-glycan interactions. The assay system includes at least one donor bead and at least one acceptor bead. A first molecule is coupled to the at least one donor bead. The first molecule comprises a protein. A second molecule is coupled to the at least one acceptor bead. The second molecule comprises a glycan. The bead-based assay system includes a screening molecule to be screened for inhibiting protein-glycan interactions. The screening molecule is enabled to interact at a protein-glycan interface of the first molecule and the second molecule.
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
G01N 33/542 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec formation d'un complexe immunologique en phase liquide avec inhibition stérique ou modification du signal, p. ex. extinction de fluorescence
A Circadian Rhythm Monitoring and Regulation (CMR) system and method that includes: a novel non-obtrusive wearable system for increasing the health and productivity of warfighters or other individuals that are disrupted by excessive, abnormal shifts in work or flights across multiple time zones. The CMR system is based on advanced sensor and software technology and models of human circadian system phototransduction and a circadian stimulator oscillator developed by applicants. It measures circadian misalignment and provides lighting suggestions for circadian rhythm maintenance and realignment.
Blood plasma samples are obtained from type 2 diabetes (T2D) patients and a concentration of F2-isoprostanes (F2I) in the sample is quantified. Plasma F2I levels assess oxidative stress levels in the patient and indicate elevated risk of T2D-associated complications including incident clinical fracture, cardiovascular complications, renal disease, etc. in the T2D cohort, independently of other risk factors. Fracture risk in the T2D population is heightened for a given bone mineral density (BMD) and is underestimated by evaluation tools such as Fracture Risk Assessment Tool (FRAX). The patient's BMD T-score can be adjusted based on F2I concentrations, capturing reductions in bone quality as well as quantity that lead to the elevated fracture risk in T2D patients. These diagnostic procedures can be effectively deployed in a patient's course of treatment merely by supplementing an existing blood panel, rather than with a separate blood draw.
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
A61P 3/00 - Médicaments pour le traitement des troubles du métabolisme
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
22.
WICKLESS HEAT PIPE AND ASSOCIATED SYSTEM AND METHOD OF MANUFACTURING
A wickless heat pipe includes a body extending along a body axis from a first end to an opposing second end and defines an interior space. A liquid working fluid is retained within the interior space of the body and includes a mixture of a first liquid and a second liquid that is different from the first liquid. The mixture is about a 50:50 binary mixture of the first liquid and the second liquid, and the fill ratio of the liquid working fluid is about 10%.
F28D 15/02 - Appareils échangeurs de chaleur dans lesquels l'agent intermédiaire de transfert de chaleur en tubes fermés passe dans ou à travers les parois des canalisations dans lesquels l'agent se condense et s'évapore, p. ex. tubes caloporteurs
H01L 23/34 - Dispositions pour le refroidissement, le chauffage, la ventilation ou la compensation de la température
23.
DISCOVERY OF 2D MATERIALS CAPABLE OF SECOND HARMONIC GENERATION
In one embodiment, there is provided a method for discovering a two-dimensional (2D) material capable of second harmonic generation (SHG). The method includes training, by a training module, an SHG material discovery module based, at least in part, on one or more training machine learning (ML) descriptors. The method further includes predicting, by the trained SHG material discovery module, an SHG for a candidate material based, at least in part, on a received material descriptor. The received material descriptor is associated with the candidate material.
G02F 1/00 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p. ex. commutation, ouverture de porte ou modulationOptique non linéaire
G01N 21/00 - Recherche ou analyse des matériaux par l'utilisation de moyens optiques, c.-à-d. en utilisant des ondes submillimétriques, de la lumière infrarouge, visible ou ultraviolette
Photonic tensor cores that utilize optical modulators to perform matrix multiplication. Optical signals are encoded with matrix values via electrical signals applied by the optical modulators. Dot product engines combine the encoded optical signals and provide product photocurrent signals for conversion to digital electrical signals.
G06E 3/00 - Dispositifs non prévus dans le groupe , p. ex. pour traiter des données analogiques hybrides
G06N 3/067 - Réalisation physique, c.-à-d. mise en œuvre matérielle de réseaux neuronaux, de neurones ou de parties de neurone utilisant des moyens optiques
25.
SYSTEMS AND METHODS FOR TESTING ELECTRONIC DEVICES
A system for testing electronic devices, including power electronics, includes a thermal management apparatus for controlling the temperature around the devices-under-test, a selector switch for connecting the devices to a characterization instrument, and a control apparatus for controlling the application of test signals to the devices, the thermal management apparatus, the selector switch, and the devices-under-test, and for receiving and processing test data.
Target biomarkers, e.g., chemokine ligand 9 (CXCL9), chemokine ligand 10 (CXCL10), etc., are detected in human urinary samples via magnetic particle-antibody complexes. These complexes bind to the target biomarkers in the sample and enable magnetic enrichment of the biomarkers into a portion of that sample. Sandwich structure complexes are prepared via further contact with DNA barcode-antibody complexes that include CRISPR/Cas recognition sites, e.g., for Cas9, Casl2a, Cast 3 a, etc. Cas-RNA complexes activate upon binding with the DNA barcodes, resulting in cleavage of reporter complexes, e.g., fluorophore-biotin (FB) reporter, fluorophore-quencher (FQ) reporter, that can be detected as an indicator of biomarker concentration in the sample. A limit of detection for urinary biomarkers of 18 pg/mL was demonstrated in a patient sample via naked-eye detection using commercially available lateral flow assay test strips configured to bind cleaved portions of the reporter complexes.
C12Q 1/34 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase
G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
G01N 33/535 - Production de composés immunochimiques marqués avec un marqueur enzymatique
G01N 33/542 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec formation d'un complexe immunologique en phase liquide avec inhibition stérique ou modification du signal, p. ex. extinction de fluorescence
27.
SYSTEMS AND METHODS OF PREDICTING STUDENT RETENTION RATES
Systems and methods of predicting the retention rates of students attending an educational institution are provided. The method includes receiving an initial dataset related to a cohort of students attending the educational institution, dividing the initial dataset into a training dataset and a testing dataset, training a predictive algorithm via the training dataset to generate a prediction model, and processing the testing dataset via the prediction model to output a prediction results dataset. The prediction results dataset includes a listing of the cohort of students organized from most likely to leave the educational institution to least likely to leave the educational institution. The method includes filtering a percentage of the prediction results dataset to identify a watchlist of students likely to leave the educational institution.
A composition is orally or topically administered to a patient susceptible to infection by an orthopoxvirus such as monkeypox (mpox). The composition includes inhibitors configured to bind to orthopoxvirus envelope proteins, e.g., MPXV A29 from mpox. The inhibitors can include sulfated polysaccharides or glycans such as heparin, chondroitin sulfate A, chondroitin sulfate B (dermatan sulfate), chondroitin sulfate C, chondroitin sulfate D, chondroitin sulfate E, pentosan polysulfate, mucopolysaccharide polysulfate, or combinations thereof. Binding of the composition to the envelope proteins inhibits the interaction between the virions and heparan sulfate proteoglycans (HSPG) and thus the ability of the virions to enter the host cell. Limiting this transport across the host cell membrane inhibits initial viral infection, as well as limits spread of that infection from cell to cell even in the event viral infection is initially achieved, providing significantly improved patient treatment and recovery outcomes relating to orthopoxvirus infections such as mpox.
The present disclosure includes implantable screws, implants, and systems. The implantable screws including a proximal section, a distal section, and a middle section with two members coupling the proximal section and the distal section. The implantable screws may be used by applying a physiological load onto the first implantable screw and the second implantable screw to flex a middle section of each implantable screw and displace a proximal section relative to a distal section of each implantable screw.
A61B 17/70 - Dispositifs de mise en position ou de stabilisation de la colonne vertébrale, p. ex. stabilisateurs comprenant un liquide de remplissage dans un implant
30.
COMPOSITIONS INCORPORATING SULFATED POLYSACCHARIDES FOR INHIBITING SARS-COV-2
The composition inhibits severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) via competitive binding to SARS-COV-2 spike protein. The composition includes a plurality of sulfated glycosaminoglycans which bind to SARS-COV-2 spike protein, preventing binding to and uptake by host cells. The sulfated glycosaminoglycans, including N-, 2-O, 3-O, or 6-O sulfate groups, or combinations thereof, include heparins and fucoidans, such as those isolated from brown seaweed. The compositions show antiviral activity, with EC50 as low as 0.08 μM, and low cytotoxicity, making it promising for clinical use. While established SARS-COV-2 treatments such as remdesivir need to be administered intravenously, the compositions discussed herein are advantageously capable to being delivered as a nasal spray, metered dose inhaler, oral delivery, etc.
A slow-light photonic modulator includes a silicon-on-insulator substrate that includes a silicon device layer on top of a silicon dioxide buried layer. A ridge waveguide is formed partially etching the silicon device layer. The ridge waveguide includes a grating arm and a reference arm. A grating waveguide and a grating electrode are in the grating arm. A straight waveguide and a reference electrode are in the reference arm. A lateral junction is formed by doping the ridge waveguide with p-type and n-type dopants. In some embodiments, the slow-light photonic modulator further includes an unequal phase shifter architecture that is configured to set the modulator in quadrature without the use of external waveguide heaters.
G02F 1/025 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p. ex. commutation, ouverture de porte ou modulationOptique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur basés sur des éléments à semi-conducteurs ayant des barrières de potentiel, p. ex. une jonction PN ou PIN dans une structure de guide d'ondes optique
32.
SYSTEM FOR HEATING AND COOLING SYSTEM WITH STAND-ALONE MODULAR UNITS
One or more temperature control units are distributed throughout an environment to provide localized heating and cooling. The temperature control units include a thermal storage system including one or more substances of high latent heat capacity, a heat distribution surface, a solid-state heat pump positioned between the thermal storage system and the heat distribution surface, an environmental sensing module including a proximity sensor, and unit control modules in communication with the solid-state heat pumps. The solid-state heat pumps are individually controllable so that heating and cooling can be provided simultaneously from separate heat pumps in the same temperature control unit, or separate temperature control units in the same environment. The system also senses the presence and location of an individual in the environment, and turns the distributed temperature control units on and off accordingly to provide optimum heating and cooling to the individual without heating or cooling the entire environment.
The composition inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) via competitive binding to SARS-CoV-2 spike protein. The composition includes a plurality of sulfated glycosaminoglycans which bind to SARS-CoV-2 spike protein, preventing binding to and uptake by host cells. The sulfated glycosaminoglycans, including N-, 2-O, 3-O, or 6-O sulfate groups, or combinations thereof, include heparins and fucoidans, such as those isolated from brown seaweed. The compositions show antiviral activity, with EC50 as low as 0.08 μM, and low cytotoxicity, making it promising for clinical use. While established SARS-CoV-2 treatments such as remdesivir need to be administered intravenously, the compositions discussed herein are advantageously capable to being delivered as a nasal spray, metered dose inhaler, oral delivery, etc.
A membrane for separating organic solvents such as methanol and toluene is provided. A plurality methacrylate polymer brushes, e.g., composed of hydroxyethyl methacrylate (HEMA) monomers or aminoethyl methacrylate (AEMA) monomers, are grafted from a crosslinked polyimide support using Single Electron Transfer-Living Radical Polymerization (SET-LRP). The polymer brushes themselves are also crosslinked by ethylene glycol dimethacrylate (EGDMA), triethylene glycol dimethacryalte (TEGDMA) trimesic acid, and/or itaconic acid. These hydrophilic polymeric brush membranes demonstrate pore stiffening and yet also opening, obtaining high selectivity at reasonable permeability and reduced energy requirements for commercially relevant separations, e.g., methanol/toluene. The addition of the crosslinker prevents loss of selectivity as a result of imparting increased rigidity, enabling the membranes to be operated at higher operating pressures for increased throughput. These membranes would be beneficial for use in pharmaceutical, chemical, petroleum, food, and biotechnology industries, e.g., in the manufacture of polymethacrylic acid, the manufacture of paraxylene, etc.
B01D 67/00 - Procédés spécialement adaptés à la fabrication de membranes semi-perméables destinées aux procédés ou aux appareils de séparation
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétésProcédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
B01D 69/10 - Membranes sur supportSupports pour membranes
B01D 71/40 - Polymères d'acides non saturés ou de leurs dérivés, p. ex. sels, amides, imides, nitriles, anhydrides, esters
C07C 7/144 - Purification, séparation ou stabilisation d'hydrocarburesEmploi d'additifs par emploi de membranes, p. ex. par perméation sélective
A cross-connect switch architecture is described. A cross-connect switch device includes a cross-point switch array, a plurality of photo detectors and a plurality of amplifiers. The cross-point switch array includes a plurality of switches. Each switch is coupled between a respective photo detector and a respective amplifier and is configured to couple the respective photo detector to the respective amplifier when the switch is selected.
H04Q 11/00 - Dispositifs de sélection pour systèmes multiplex
H03F 3/08 - Amplificateurs comportant comme éléments d'amplification uniquement des tubes à décharge ou uniquement des dispositifs à semi-conducteurs comportant uniquement des dispositifs à semi-conducteurs commandés par la lumière
The present disclosure provides methods related to the purification of a biologic. In particular, the present disclosure methods for purifying a biologic using a multifunctional chromatography medium comprising porous beads or particles having a defined pore diameter distribution and one or more ligands conjugated to the surface of the pores capable of removing process-related impurities and product-related impurities from a target biologic.
C07K 1/16 - ExtractionSéparationPurification par chromatographie
B01D 15/34 - Séparation par sélection en fonction de la taille, p. ex. chromatographie d'exclusion de tailleFiltration sur gelPerméation
B01D 15/36 - Adsorption sélective, p. ex. chromatographie caractérisée par le mécanisme de séparation impliquant une interaction ionique, p. ex. échange d'ions, paire d'ions, suppression d'ions ou exclusion d'ions
Source and target vectors encode roles of a node in a directed graph as a source and a target role respectively. Source and target query matrices and source and target key matrices are learned based on the directed graph. The source query matrix and the target key matrix are projected and scaled to create a source-target attention matrix and the target query matrix and the source key matrix are projected and scaled to create a target-source attention matrix. The attention matrices are combined to generate a source-target vector-edge encoding and a target-source vector-edge encoding, and are also biased and gated to generate a modified source-target attention matrix and a modified target-source attention matrix, respectively. Source encodings and target encodings are generated using the modified attention matrices. A classification task is performed with respect to the obtained directed graph based on the generated source encodings and the generated target encodings.
Separation constructs such as membranes, porous beads, etc. are modified with a plurality of oligomeric ligands. The ligands are bound to the surface of the separation substrates via linker constructs such as acrylate groups or azide groups, e.g., via Single-Electron Transfer-Living Radical Polymerization (SET-LRP). A plurality of spacer constructs, such as polyethyleneglycol (PEG) groups and hydrocarbyl groups, separate the linker constructs from oligomer constructs. The oligomer constructs can include between 5% and about 10% guanine and about 90% to about 95% thymine, and can further include between about 20 and about 60 nucleotides including at least 15 thymines and at least 1 guanine. The oligomer constructs exhibit improved binding of mRNA with oligo-dAn tails, e.g., for purification of mRNA production and commercialization, enabling fast, efficient, and continuous production of mRNA vaccines such as those against coronaviruses, e.g., SARS-CoV-2.
Disclosed herein are novel microbial polycultures of two or more cell strains, capable of producinges, flavonoids, and anthocyanidin-3-O-glucosides, and methods of use thereof. Also disclosed is a microbial cell capable of producing phenylpropanoic acids, and methods of use thereof.
C12P 19/58 - Préparation d'O-glucosides, p. ex. glucosides avec un atome d'oxygène du radical saccharide lié directement, uniquement par des atomes de carbone acycliques, à un hétérocycle autre que saccharide, p. ex. bléomycine, phléomycine
C12N 9/00 - Enzymes, p. ex. ligases (6.)ProenzymesCompositions les contenantProcédés pour préparer, activer, inhiber, séparer ou purifier des enzymes
C12N 9/02 - Oxydoréductases (1.), p. ex. luciférase
C12N 9/04 - Oxydoréductases (1.), p. ex. luciférase agissant sur des groupes CHOH comme donneurs, p. ex. oxydase de glucose, déshydrogénase lactique (1.1)
C12P 17/06 - Préparation de composés hétérocycliques comportant O, N, S, Se ou Te comme uniques hétéro-atomes du cycle l'oxygène comme unique hétéro-atome du cycle contenant un hétérocycle à six chaînons, p. ex. fluorescéine
40.
SPECTRAL DATA AUGMENTATION FOR SINGLE DOMAIN GENERALIZATION
A machine learning model is trained using original source domain data through empirical risk minimization and a model sensitivity map is computed. Each sensitive frequency point on the model sensitivity map is targeted. An adversarial technique is employed to generate spectral adversarial images based on the model sensitivity map and an image amplitude spectrum is augmented. The generated spectral adversarial images are mixed with the original source domain data to finetune the machine learning model and deployment of the finetuned machine learning model is facilitated.
G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
G06V 10/776 - ValidationÉvaluation des performances
G06V 10/80 - Fusion, c.-à-d. combinaison des données de diverses sources au niveau du capteur, du prétraitement, de l’extraction des caractéristiques ou de la classification
41.
SYSTEMS AND METHODS OF MULTI-MODAL MULTI-DIMENSIONAL IMAGE REGISTRATION
Multi-modal image registration in which a fixed image from a first imaging device is received; a moving image from a second imaging device is received, comprising a plurality of moving image frames. For each moving image frame: a set of candidate fixed image slices from the fixed image are identified based on a set of geometric parameters derived from an application of a template moving image to the fixed image. Feature extraction is performed on the candidate fixed image slices and on each moving image frame. A candidate feature vector from the set of candidate feature vectors with the highest similarity to each moving image feature vector is identified, and a location for each moving image feature vector relative to the fixed image is assigned based on the location of the identified candidate feature vector.
G06T 7/33 - Détermination des paramètres de transformation pour l'alignement des images, c.-à-d. recalage des images utilisant des procédés basés sur les caractéristiques
A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
A NFCBRS system for installation on a surface of a building includes a body and one or more spacers. The body includes a core that includes a natural fiber wool that is bonded together and a composite skin that covers the core and includes a natural fiber impregnated with a thermoset resin. The one or more spacers are structured to be positioned between the body and a surface of a building to define a ventilation cavity between the body and the surface of the building. The ventilation cavity is structured to inhibit a build-up of moisture between the surface of the building and the body.
E04C 2/296 - Éléments de construction de relativement faible épaisseur pour la construction de parties de bâtiments, p. ex. matériaux en feuilles, dalles ou panneaux caractérisés par des matériaux spécifiés composés de matériaux couverts par plusieurs des groupes , , ou de matériaux couverts par un de ces groupes avec un matériau non spécifié dans l'un de ces groupes au moins un des matériaux étant isolant composés de matériau isolant et de matériau en feuilles non métallique ou non spécifié
E04C 2/32 - Éléments de construction de relativement faible épaisseur pour la construction de parties de bâtiments, p. ex. matériaux en feuilles, dalles ou panneaux caractérisés par la forme ou la structure formés d'un matériau ondulé ou cannelé analogue à des feuillesÉléments de construction de relativement faible épaisseur pour la construction de parties de bâtiments, p. ex. matériaux en feuilles, dalles ou panneaux caractérisés par la forme ou la structure composés de couches de ce genre avec ou sans couches d'un matériau plat en feuilles
A multicopter rotor fault diagnosis system includes a multicopter, a plurality of local sensors, and a controller. The multicopter includes a body, a plurality of booms secured to the body, and a plurality of rotors. Each boom has a proximal end secured to the body and extends radially outward to a distal end. Each rotor is secured to the distal end of a respective boom. Each sensor is secured to a respective boom and is positioned a distance from the body. The local sensors are configured to measure out-of-plane strain of the booms and to continuously generate boom strain signals. The controller is in communication with the body and the local sensors. The controller is configured to receive the continuously generated boom strain signals and to perform a pattern recognition algorithm to simultaneously detect and identify faults associated with the rotors.
For at least a first two iterations: for candidate training algorithms, obtain from clients, a score corresponding to a best hyperparameter, based on a fraction of available training data; for the algorithms, aggregate the scores and update a projected score for each of the algorithms; and increase the fraction of available training data to be used in a subsequent one of the at least a first two iterations or a first one of a plurality of subsequent iterations. For the subsequent iterations: for a best-performing subset of the algorithms, obtain from the clients, an updated best hyperparameter and corresponding score, based on a further increased fraction of available training data as compared to a final iteration of at least first two iterations or a previous one of the subsequent iterations; and for the best-performing subset, aggregate the obtained updated scores and further update a projected score for each subset member.
The systems and methods convert methane to one or more products using a green rust material in spontaneous, electrocatalytic, and photochemical reactions under aerobic and anaerobic conditions. In an embodiment, a first electrode that includes a green rust material and a second electrode are contacted by an electrolyte, where the first and second electrodes are separated by an ion exchange membrane. For electrocatalytic reactions, a potential difference is applied across the electrodes. For photochemical reactions, the green rust material is illuminated. Liquid products (e.g., methanol and/or acetate) can be removed from the electrolyte in contact with the green rust material after the desired contact period.
C01B 3/26 - Production d'hydrogène ou de mélanges gazeux contenant de l'hydrogène par décomposition de composés organiques gazeux ou liquides d'hydrocarbures avec des catalyseurs
C01B 3/40 - Production d'hydrogène ou de mélanges gazeux contenant de l'hydrogène par réaction de composés organiques gazeux ou liquides avec des agents gazéifiants, p. ex. de l'eau, du gaz carbonique, de l'air par réaction d'hydrocarbures avec des agents gazéifiants avec des catalyseurs caractérisée par le catalyseur
A system for free-space optical communication includes a first light source configured to emit an information signal, a spatial light modulator configured to shape the information signal, a second light source configured to emit a plurality of beam pulses, at least one spiral phase plate configured to convert each of the plurality of beam pulses into a plurality of vortical beam filaments, and a mirror coupler configured to combine the information signal and the plurality of vortical beam filaments to form a multi-filament beam having the plurality of vortical beam filaments embedded within the information signal. When the multi-filament beam passes through an optically obstructed space the plurality of vortical beam filaments are configured to clear at least one channel in the optically obstructed space for the information signal to pass through.
Customized recombinant proteins are designed and produced by cultures of Pseudomonas bacteria, including natural and recombinant silk proteins, fluorescent proteins, and elastin-like proteins (ELPs). The recombinant genes can be expressed via insertion directly into the Pseudomonas bacteria, or via the transformation of a suitably designed recombinant plasmid. Advantageously, the carbon source used as the nutrient source by the Pseudomonas bacteria is derived from non-traditional nutrient sources, such as exogenous rhamnolipids, hydrocarbons, polyolefins, polyesters, and pyrolysis products of waste plastic, e.g., pyrolysis products of polyethylene or poly (ethylene terephthalate). The waste feedstocks can be added to particularly designed growth media for sustained bacterial culture and protein production. These feedstocks allow for upcycling of plastic waste into high value protein products, such as recombinant silk fibroins.
C08J 11/10 - Récupération ou traitement des résidus des polymères par coupure des chaînes moléculaires des polymères ou rupture des liaisons de réticulation par voie chimique, p. ex. dévulcanisation
C07K 14/435 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
C07K 14/78 - Peptides du tissu connectif, p. ex. collagène, élastine, laminine, fibronectine, vitronectine ou globuline insoluble à froid [CIG]
C12N 15/78 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes procaryotes autres que E. coli, p. ex. Lactobacillus, Micromonospora pour Pseudomonas
In one embodiment, there is provided a dissectography module for dissecting a two-dimensional (2D) radiograph. The dissectography module includes an input module, an intermediate module, and an output module. The input module is configured to receive a number K of 2D input radiographs, and to generate at least one three-dimensional (3D) input feature set, and K 2D input feature sets based, at least in part, on the K 2D input radiographs. The intermediate module is configured to generate a 3D intermediate feature set based, at least in part, on the at least one 3D input feature set. The output module is configured to generate output image data based, at least in part, on the K 2D input feature sets, and the 3D intermediate feature set. Dissecting corresponds to extracting a region of interest from the 2D input radiographs while suppressing one or more other structure(s).
G06V 10/25 - Détermination d’une région d’intérêt [ROI] ou d’un volume d’intérêt [VOI]
G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
49.
SYSTEMS AND METHODS FOR RISK-RESPONSIVE BIDDING FOR RENEWABLE POWER GENERATION
Financial engineering asset securitization principles are employed to carve out "risk-free" power generation capability from renewable assets, e.g., wind and solar. Dynamically evolving tranches of renewable power are defined that allow renewable power generators to participate in day-ahead power markets with bids competitive with those for conventionally-derived power. Historical data sets containing, e.g., renewable power generation mean, spread, maximum, minimum, and forecast, are used to define a. characteristic day projection. A tranche of renewable power generated during each hour is prepared based on the characteristic day projection, using the 4th percentile of generated power as the attachment point and the 5th-7th percentile as detachment point, corresponding to a 96% likelihood of successfully fulfilling a bid contract, competitive with conventionally-derived power. Bid price curves are prepared for each hour, and a bid for the day-ahead market composed of the bid price curves is prepared. A rating indicating how likely a renewable generator will fulfill a contract's obligations can be provided as well.
Functionalized membranes are produced via grafting of polymer brushes to the membrane surface for use, e.g., in separation and purification of biomolecules. One or more initiators are attached to the membrane surface. A reactant substrate, such as a copper metal plate, is placed adjacent the membrane. A reaction medium is then provided in fluid contact with the membrane and the reactant substrate, the reaction medium including one or more monomers, one or more ligands, and one or more solvents. The polymer brushes are grown on the membrane via Cu(0)-mediated controlled radical polymerization involving the reactant substrate and the reaction medium. This reaction process uses fewer numbers and amounts of chemicals compared to other controlled radical polymerization reactions such as ATRP. The reaction can take place at room temperature, which is more energy efficient than other CRPs which occur at a much higher temperatures. The reaction process described herein is also sixteen times faster than the standard ATRP method without sacrificing subsequent separation performance.
B01D 67/00 - Procédés spécialement adaptés à la fabrication de membranes semi-perméables destinées aux procédés ou aux appareils de séparation
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétésProcédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
B01D 71/82 - Matériaux macromoléculaires non prévus spécifiquement dans un seul des groupes caractérisés par la présence de groupes déterminés, p. ex. introduits par un post-traitement chimique
C08J 7/16 - Modification chimique par des composés polymérisables
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
51.
MANIPULATION OF GASEOUS ION BEAMS WITH ACOUSTIC FIELDS
An apparatus for manipulation of a gaseous ion beam advantageously uses an ultrasonic acoustic field rather than physical structures, which can become contaminated or electromagnetic fields, which require high field strengths. Such apparatuses comprise an ion source having an outlet configured to release the gaseous ion beam at a flow rate along a first path; a transducer configured to generate an acoustic field along a second path that intersects or overlaps with the first path; and an ion detector. Aspects of the disclosure also provide methods of using the same to deflect, gate, focus, and separate gaseous ion beams.
G01N 27/62 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'ionisation des gaz, p. ex. des aérosolsRecherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant les décharges électriques, p. ex. l'émission cathodique
Systems for capturing handwriting or other data corresponding to the movement of a stylus are provided. In some embodiments, such systems include an electronic inscription device with a flexible display screen that is extendable from and retractable into one or more housings. The device includes stylus position sensing circuitry for capturing data corresponding to movement of a stylus relative to the flexible display screen. In some embodiment, one or more of the housings include retraction and locking components that hold the screen in an extended position for use. In some embodiments, the stylus position sensing circuitry senses infrared signals from the tip of a stylus. In some embodiments, the system also includes a stylus with an infrared strobe tip.
G06F 3/04883 - Techniques d’interaction fondées sur les interfaces utilisateur graphiques [GUI] utilisant des caractéristiques spécifiques fournies par le périphérique d’entrée, p. ex. des fonctions commandées par la rotation d’une souris à deux capteurs, ou par la nature du périphérique d’entrée, p. ex. des gestes en fonction de la pression exercée enregistrée par une tablette numérique utilisant un écran tactile ou une tablette numérique, p. ex. entrée de commandes par des tracés gestuels pour l’entrée de données par calligraphie, p. ex. sous forme de gestes ou de texte
G06F 3/0354 - Dispositifs de pointage déplacés ou positionnés par l'utilisateurLeurs accessoires avec détection des mouvements relatifs en deux dimensions [2D] entre le dispositif de pointage ou une partie agissante dudit dispositif, et un plan ou une surface, p. ex. souris 2D, boules traçantes, crayons ou palets
G06F 40/171 - Édition, p. ex. insertion ou suppression au moyen d’encre numérique
53.
MOTION CORRECTION WITH LOCALLY LINEAR EMBEDDING FOR COMPUTED TOMOGRAPHY
A CT apparatus in which the x-ray source is coupled to a source robotic arm and the detector is coupled to a detector robotic arm. A motion correction module utilizes a locally linear embedding motion correction algorithm with normalized cross correlation to estimate the geometric parameters associated with the positions of the source and detector and the angle of the detector. These estimates are used to reconstruct the image data and produce corrected images with fewer errors resulting from patient movement, misalignments, and coordination issues in the system.
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (USA)
RENSSELAER POLYTECHNIC INSTITUTE (USA)
Inventeur(s)
Petrukhin, Konstantin
Cioffi, Christopher, L.
Abrégé
New therapies for macular degeneration and TTR amyloidosis are provided based on a co-drug that represents a conjugate of two distinct chemical entities as well as co- administration and sequential administration of the two chemical entities. The first component ("selective TTR ligand") is a chemical entity that engages TTR (transthyretin) of the RBP4 (retinol binding protein 4) -TTR complex, which is involved in delivery of retinol to the retina. This component reduces traffic of retinol from circulation to the retina and provides stabilization of TTR tetramers. The second component ("C20-D3-visual- chromophore-producing compound") is a C20-D3-modified retinoid or carotenoid that upon metabolism in a mammal can eventually produce a C20-D3 visual chromophore that represents C20-D3-9-cis-retinaldehyde or C20-D3-11-cis-retinaldehyde in the retina. Deuteration at the C20 position reduces the formation of lipofuscin bisretinoid while other functions (such as providing a precursor for in vivo synthesis of the visual chromophore, 11-cis-retinaldehyde) are not reduced.
C07D 401/04 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
C07D 401/14 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant au moins trois hétérocycles
C07D 403/04 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
A61K 31/07 - Composés du rétinol, p. ex. vitamine A
A61K 31/395 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines
A61K 31/445 - Pipéridines non condensées, p. ex. pipérocaïne
A61K 31/41 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec plusieurs hétéro-atomes cycliques, l'un au moins étant l'azote, p. ex. tétrazole
A composition includes a contraceptive chimeric virus-like particle with an antigenic carrier domain and one or more antigenic regions from a sperm cell in the antigenic carrier domain, with the antigenic carrier domain including human papillomavirus L1 capsid protein and the antigenic regions including one or more structural elements of the Catsper ion channel complex. When administered to a patient, the contraceptive vaccine stimulates production of anti-sperm antibodies that, upon binding to a sperm cell, inhibit the sperm cell's motility and thus inhibit the ability of the sperm cell to fertilize an egg cell. The induced immunoinfertility of the composition can be reversed for brief or extended lengths of time by overdosing the patient with a reversal agent lacking the antigenic carrier domain but having a protein sequence substantially identical to that of the one or more antigenic regions to sequester the anti-sperm antibodies.
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (USA)
RENSSELAER POLYTECHNIC INSTITUTE (USA)
Inventeur(s)
Petrukhin, Konstantin
Cioffi, Christopher, L.
Abrégé
New therapies for macular degeneration and TTR amyloidosis are provided based on a co-drug that represents a conjugate of two distinct chemical entities as well as co- administration and sequential administration of the two chemical entities. The first component ("bispecific RBP4 /TTR ligand") is a chemical entity that engages TTR ( transthyretin) and RBP4 ( retinol binding protein 4 ) of the RBP4 -TTR complex, which is involved in delivery of retinol to the retina. This component reduces traffic of retinol from circulation to the retina and provides stabilization of TTR tetramers. The second component ("C20-D3-visual-chromophore-producing compound" ) is a C20 -D3 -modified retinoid or carotenoid that upon metabolism in a mammal can eventually produce a C20-D3 visual chromophore that represents C20 -D3- 9-cis-retinaldehyde or C20-D3-11-cis-retinaldehyde in the retina. Deuteration at the C20 position reduces the formation of lipofuscin bisretinoid while other functions ( such as providing a precursor for in vivo synthesis of the visual chromophore, 11-cis-retinaldehyde ) are not reduced.
C07D 401/04 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
C07D 401/14 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant au moins trois hétérocycles
C07D 403/04 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
A61K 31/07 - Composés du rétinol, p. ex. vitamine A
A time-of-flight (TOF) array including a plurality of cameras is positioned with a coplanar Higher Order Ambisonics (HOA) array including a plurality of microphones above a target area such as a room or space for analyzing speaker activity in that area. The HOA microphone array iteratively samples sound energy level frames captured by the microphones to identify a sound vector associated with the global maximum energy level in the sound energy level frame. This sound vector is fused with the data from the TOF camera array that identified the positions of sound sources in the target area to associate produced sound corresponding with the sound vector with a physical active sound source in the target area. A beamformer can then be used to save audio corresponding to the sound vector and discard audio not associated with the sound vector to produce a sound recording associated with the active sound source.
Materials, methods, and systems for affinity membrane purification of nucleic acid products advantageously (i) reduce the residence times of the recovery process, (ii) allow continuous processing, (iii) retain a higher percentage of nucleic acids having the target structure, and (iv) reduce the "footprint" of the equipment. Systems include one or more bioreactors to synthesize nucleic acids. One or more affinity membrane separators modified by the inclusion of a peptide obtained using rational design, in silico optimization, and/or combinatorial screening. One or more diafiltration modules include flat sheet microporous membranes, cellulose hollow fiber microporous affinity membranes, or combinations thereof.
B01D 15/38 - Adsorption sélective, p. ex. chromatographie caractérisée par le mécanisme de séparation impliquant une interaction spécifique non couverte par un ou plusieurs des groupes , p. ex. chromatographie d'affinité, chromatographie d'échange par ligand ou chromatographie chirale
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
C12P 19/34 - Polynucléotides, p. ex. acides nucléiques, oligoribonucléotides
G16B 5/00 - TIC spécialement adaptées à la modélisation ou aux simulations dans la biologie des systèmes, p. ex. réseaux de régulation génétique, réseaux d’interaction entre protéines ou réseaux métaboliques
A61K 39/215 - Coronaviridae, p. ex. virus de la bronchite infectieuse aviaire
A61P 31/14 - Antiviraux pour le traitement des virus ARN
60.
SYSTEM AND METHOD FOR METAL ARTIFACT REDUCTION IN MEDICAL IMAGES USING A DENOISING DIFFUSION PROBABALISTIC MODEL
Various systems and methods are provided for MAR in CT images. A corrupted CT image, of a region of interest (ROI) of a subject, including artifacts caused by a metal object in the subject may be acquired. A corrupted sinogram including a corrupted region of corrupted data caused by the metal object and an uncorrupted region of uncorrupted data may be generated. A mask sinogram that delineates the corrupted region of the corrupted data may be generated. A corrected sinogram including the uncorrupted region of the uncorrupted data and an inpainted region of inpainted data corresponding to the corrupted region may be generated using a denoising diffusion probabilistic model, the corrupted sinogram, and the mask sinogram. A corrected CT image, of the ROI of the subject, that includes reduced artifacts relative to the artifacts in the corrupted CT image may be generated based on the corrected sinogram.
Methods and systems are directed to multiplex detection of a bacterial pathogen in a sample. A first biotinylated lysin-derived cell wall binding domain is complexed with an avidin layer on a surface. A first bacterial pathogen detection complex including a second biotinylated lysin-derived cell wall binding domain, a detection domain, and an avidin linker complexed between the cell wall binding domain and the detection domain is also provided. The cell wall binding domains are derived from an endolysin, autolysin, bacteriocin, or exolysin, and are configured to bind a cell wall of a target bacterial pathogen. The detection domain includes one or more enzymes, fluorescent material, or DNA for emitting a signal for detection. Target bacterial pathogens present in a sample can thus be detected in a sandwich assay exhibiting increased selectivity and reduced limit of detection relative to traditional ELISA.
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
C12Q 1/26 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une oxydoréductase
C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
62.
SYSTEMS AND METHODS INCLUDING FUSED PARTICLE MEMBRANES FOR FILTRATION
Rigid or flexible polymer membranes including one contiguous porous film are provided that include a plurality of fused microstructures, e.g., microspheres, teardrops, ellipsoids, other geometric designs, or combinations thereof. The microstructures are fused via a sintering, chemical, and/or physical process, crosslinking, or combinations thereof. The membranes have a plurality of repeating microstructures in a random or ordered, e.g., face-centered cubic, arrangement and a network of throats extending through the membrane and around the fused microstructures. The microstructures and throats precisely control the microstructure of the membrane, providing consistent and uniform flow across the membrane in all three directions. Channeling concerns of polymeric membranes cast using random statistical processes, such as phase inversion and interfacial polymerization, are thus reduced. The membranes provide consistent filtration performance, e.g., of proteins and nucleic acid mixtures, while reducing the compressibility, pore wall flexibility, and ageing limitations of traditional polymeric membranes. Surface modification of the microstructures can further enhance membrane selectivity for a given separation.
METHOD FOR PRODUCING A MICROORGANISM HAVING N-DEACETYLATION ACTIVITY AND N-SULFATION ACTIVITY, METHOD FOR PRODUCING A HEPAROSAN-DERIVED COMPOUND, AND A MICROORGANISM HAVING N-DEACETYLATION ACTIVITY AND N-SULFATION ACTIVITY
The present invention relates to a method for producing a microorganism having N-deacetylation activity and N-sulfation activity, including a step (I) of modifying a nucleotide sequence of a DNA encoding N-deacetylase/N-sulfotransferase, and a step (II) of introducing the DNA containing the nucleotide sequence modified in the step (I) into a microorganism in an expressible manner, wherein the step (I) is a step of performing codon optimization according to the codon usage frequency of a biological species different from the microorganism. Further, the invention relates to a method for producing a microorganism having N-deacetylation activity and N-sulfation activity, including a step (i) of expressing a specific protein in a microorganism.
Systems, methods, and software that generate synthetic image data based on an original dataset. Some embodiments utilize a variational autoencoder trained on an original dataset to generate a latent space dataset to train a denoising diffusion model to generate synthetic latent space data which is then converted to a synthetic image by the trained decoder circuitry of the variational autoencoder. Some embodiments include enhanced privacy protection in which the original images and the synthetic images are converted to vectors, the L2 distance between a synthetic image vector and each original image vector is compared, and synthetic images for which the L2 distance is below a selected threshold are removed from the synthetic dataset.
Systems, methods, and software for reconstructing sparse projection data to full projection data and refining the resulting image volume using denoising diffusion probabilistic models in both the projection and image domains. A trained DDPM in the projection domain is used to inpaint projection data into sparse sub-volumes of a sparce projection dataset. The repaired sub-volumes are assembled into an assembled full projection dataset, which is then reconstructed into an image volume. A trained DDPM in the image domain then refines sub-volumes of the reconstructed image volume to produce a refined tomographic image volume.
A system for producing rebar includes a pultruding machine configured to receive a flexible rebar preform. The flexible rebar preform includes at least one reinforcement filament, and at least one thermoplastic filament. The at least one reinforcement filament, and the at least one thermoplastic filament are arranged in a selected distribution across a cross-section of the preform. The pultruding machine includes a pulling apparatus, a rebar cutting apparatus, and a bending apparatus. The pultruding machine is configured to heat the flexible rebar preform to a first temperature. The first temperature is greater than or equal to a melt temperature of the thermoplastic filaments. The pulling apparatus is configured to pull the flexible rebar preform through a pultrusion die to form the rebar. The rebar cutting apparatus is configured to cut the rebar at a prespecified length. The bending apparatus is configured to bend the cut rebar to a prespecified bend geometry.
B29C 70/54 - Parties constitutives, détails ou accessoiresOpérations auxiliaires
B29K 105/10 - Présentation, forme ou état de la matière moulée contenant des agents de renforcement, charges ou inserts de grande longueur, p. ex. ficelles, mèches, mats, tissus ou fils orientés
Provided herein are conformation-specific antibodies which bind to protein aggregates, such as amyloid fibrils, including aggregates of glucagon and liraglutide. Also provided are methods of using the antibodies to detect protein aggregates in samples, and methods for identifying aggregate-binding antibodies.
C07K 16/26 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des hormones
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
G01N 33/74 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des hormones
22 to one or more multicarbon products using a green rust material in spontaneous and electrocatalytic reactions. In an embodiment, a first electrode that includes a green rust material and a second electrode are contacted by an electrolyte, where the first and second electrodes are separated by a proton exchange membrane. For electrocatalytic reactions, a potential difference is applied across the electrodes. Multicarbon products can be removed from the electrolyte in contact with the green rust material after the desired contact period.
B01J 20/02 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation contenant une substance inorganique
70.
SYNTHETIC NETWORK GENERATOR FOR COVERT NETWORK ANALYTICS
A method of generating a synthetic network includes receiving, by a group structure identification module, anonymized input data related to an original network. The anonymized input data includes an anonymized list of nodes, a list of edges and a list of groups. The method further includes determining, by the group structure identification module, for each pair of nodes, a probability of an edge between the pair of nodes. A resulting list of probabilities corresponds to a summary group structure. The method further includes generating, by a synthetic random network generation module, at least one synthetic random network based, at least in part, on the determined probabilities.
BacillusB. megateriumB. megateriumB. megateriumB. megateriumB. megaterium generate the protein product and further secrete that product into the growth media, mitigating toxicity of the disordered proteins and facilitating continuous thereof. Previous recombinant silk protein production methods suffered from low-yields and batch-production limitations.
A system for tissue staining includes an upper housing, a lower housing, and a microscope lens. The upper housing includes a first reservoir configured to retain a solution therein, a valve attached to the reservoir including a turning knob, a first conduit configured to transport the solution, and a funnel fluidly connected to the first conduit. The lower housing is threadedly couped to the upper housing. The lower housing includes a top cassette portion having a window, a bottom cassette portion having a recess configured to retain a tissue therein, and a gasket disposed along an outer perimeter of the bottom cassette portion. The upper portion and the lower housing are coupled via threading. The microscope lens is configured to image the tissue through the window.
G01N 21/78 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique produisant un changement de couleur
73.
SYSTEMS AND METHODS FOR REMOVAL OF CLOT MATERIAL FROM A BLOOD VESSEL
Systems and methods for removing thromboembolic material from blood vessels, including a first, outer catheter, a second, inner catheter disposed inside of the first catheter, an elongate member disposed inside of the second catheter, and a stent arranged adjacent to the distal end of the second catheter. The stent can be expanded to encapsulate at least a portion of a thrombus, and the elongate member can be rotated to break down the thrombus for removal from the blood vessel. In one or more embodiments, the first catheter is provided with aspiration capability to assist in removal of the thrombus.
A61B 17/22 - Instruments pour comprimer les ulcères ou similaires placés sur les organes internes du corpsInstruments pour curer les cavités des organes du corps, p. ex. des osInstruments, dispositifs ou procédés chirurgicaux pour l'élimination ou la destruction invasives des calculs utilisant des vibrations mécaniquesInstruments, dispositifs ou procédés chirurgicaux pour l'élimination non prévue ailleurs des obstructions dans les vaisseaux sanguins
Syringes and syringe systems for use in centrifuge machines including coupling arms for engaging the centrifuge machines. The syringe including a housing with a first coupling arm extending from a first side of the housing and a second coupling arm extending from a second side of the housing. The first side is opposite the second side. The syringe also includes at least one plunger slidingly received within the housing. Methods of using the syringes and syringe system for extracting and injecting platelet-rich plasma are also disclosed.
A61M 5/315 - PistonsTiges de pistonGuidage, blocage, ou limitation des mouvements de la tigeAccessoires disposés sur la tige pour faciliter le dosage
A61J 1/05 - Récipients spécialement adaptés à des fins médicales ou pharmaceutiques pour recueillir, stocker ou administrer du sang, du plasma ou des liquides à usage médical
A61M 5/145 - Perfusion sous pression, p. ex. utilisant des pompes utilisant des réservoirs sous pression, p. ex. au moyen de pistons
75.
RECOMBINANT ENZYME FOR THE ACCURATE INSERTION OF DNA SEQUENCES IN EUKARYOTIC CELLS
A construct for site-specific insertion of DNA fragments and transgenes into a genome includes a recombinant enzyme. The enzyme includes a modified HIV-1 integrase (HIV IN) tetramer having a plurality of mutations to favor a heterodimer of heterodimers construction with first and second outer monomers bound to first and second inner monomers, respectively. Transcription Activator Like Effectors (TALEs) are bound to N-terminal regions of the outer monomers via polypeptide linkers. The two TALEs grant the enzyme sequence specificity and prevent non-specific interactions with a target DNA structure. The modified HIV IN monomers ensure binding of TALEs to the outer-most monomers and arrangement of the TALEs relative to the HIV IN's catalytic region. Polynucleotides are bound to inner monomers of the HIV IN. Upon transport to the nucleus, either alone or within a lentiviral capsid, the TALEs interact with the DNA to localize the HIV IN, which then integrates the polynucleotides.
A system for tissue staining includes an upper housing, a lower housing, and a microscope lens. The upper housing includes a first reservoir configured to retain a solution therein, a valve attached to the reservoir including a turning knob, a first conduit configured to transport the solution, and a funnel fluidly connected to the first conduit. The lower housing is threadedly couped to the upper housing. The lower housing includes a top cassette portion having a window, a bottom cassette portion having a recess configured to retain a tissue therein, and a gasket disposed along an outer perimeter of the bottom cassette portion. The upper portion and the lower housing are coupled via threading. The microscope lens is configured to image the tissue through the window.
In an embodiment, there is provided a medical multimodal-multitask foundation model (M3FM) circuitry. The M3FM circuitry includes an image data preprocessor circuitry, an image encoder circuitry, a text data preprocessor circuitry, a text encoder circuitry, and a task encoder circuitry. The image data preprocessor circuitry is configured to divide received medical image data into a plurality of image tokens, to encode respective image token physical size data for each image token, and to combine respective encoded image token physical size data with a respective image token embedding corresponding to each image token. The image encoder circuitry is configured to map an image embedding space to a task embedding space. The text data preprocessor circuitry is configured to divide received clinical data into a plurality of clinical text tokens. The text encoder circuitry is configured to encode a plurality of text token embeddings. The task encoder circuitry is configured to extract task-specific embedding features from multimodal token embeddings.
G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
G16H 30/20 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le maniement d’images médicales, p. ex. DICOM, HL7 ou PACS
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
78.
Systems and methods for increased production of recombinant biopolymers via genome engineering and downregulation of basal expression
A system for detecting occupants in a room is provided. The system includes at least one first sensor configured to establish a background color map of the room in an unoccupied state and to detect color shift data resulting from at least one occupant entering the room, at least one second sensor configured to determine height data of the at least one occupant, and a controller configured to receive the color shift data and the height data and to generate equipment-control signals to operate at least one occupant-centric system.
G01V 8/10 - Détection, p. ex. en utilisant des barrières de lumière
H05B 47/115 - Commande de la source lumineuse en réponse à des paramètres détectés en détectant la présence ou le mouvement d'objets ou d'êtres vivants
80.
HYDRONIC SYSTEM AND METHOD FOR HEATING AND COOLING A BUILDING
A hydronic system includes a partition, a first conduit embedded in a first side of the partition, a second conduit embedded in a second side of the partition, a first sheet of finishing material covering the first conduit, a second sheet of finishing material covering the second conduit, and at least one valve and at least one pump. The at least one valve and at least one pump are configured to control a flow of a fluid inside the first conduit and the second conduit. When the hydronic system is operating in an isolating mode, the fluid flows in a first closed loop through the first conduit and the fluid flows in a second closed loop through the second conduit. When the hydronic system is operating in a heat exchange mode, the fluid flows between the first conduit and the second conduit in a third closed loop.
F24D 3/14 - Aménagements de tubes et panneaux pour le chauffage par plafond, mur ou sol incorporés dans un plafond, un mur ou un plancher
E04C 2/52 - Éléments de construction de relativement faible épaisseur pour la construction de parties de bâtiments, p. ex. matériaux en feuilles, dalles ou panneaux caractérisés par la forme ou la structure avec adaptations particulières pour usages auxiliaires, p. ex. servant au logement de conduits
F24D 19/10 - Aménagements ou montage des dispositifs de commande ou de sécurité
F24F 5/00 - Systèmes ou appareils de conditionnement d'air non couverts par ou
A luminaire includes a frame, an ambient light source positioned within the frame adjacent a first end of the frame, a downlight light source positioned within the frame adjacent a second end of the frame, a diffuser connected to the frame and at least partially surrounding the ambient light source, and a reflector configured to direct light emitted by the downlight light source. A first driver is in electrical communication with the ambient light source and is configured to adjust the illuminance of the ambient light source. A second driver is in electrical communication with the downlight light source and is configured to adjust the illuminance of the downlight light source. A controller is in electrical communication with and send control signals to the drivers to change the light sources between a plurality of illuminance modes, which includes a circadian effective mode and a circadian ineffective mode.
H05B 47/16 - Commande de la source lumineuse par des moyens de minutage
F21S 6/00 - Dispositifs d'éclairage destinés à tenir debout tout seuls
F21S 8/06 - Dispositifs d'éclairage destinés à des installations fixes destinés uniquement au montage sur un plafond ou sur une structure similaire en porte-à-faux par suspension
H05B 47/115 - Commande de la source lumineuse en réponse à des paramètres détectés en détectant la présence ou le mouvement d'objets ou d'êtres vivants
F21Y 113/20 - Combinaison de sources lumineuses de formes différentes
82.
SYSTEMS FOR FACILE VIRAL CLEARANCE VALIDATION THROUGH THE DEVELOPMENT OF FLUORESCENT VIRAL SURROGATES
Evaluating viral clearance of a sample including a drug of interest is performed via modified viral surrogate nanoparticles that mimic a target live virus equivalent. The nanoparticles include fluorescent materials and a viral surface-mimicking layer that physicochemically mimics the external surface of the target live virus equivalent. One or more capsid proteins of the live virus are bound to the nanoparticle core (for non-enveloped viruses) or incorporated into a lipid bilayer (for enveloped viruses). A process solution is formed by adding the nanoparticles to the sample. The solution is subjected to purification steps to eliminate impurities, forming a product process solution. The product process solution is filtered through a dead-end flow nanofiltration membrane separator configured to bind the fluorescent nanoparticles. A load process solution is filtered as well. Baseline decomposition of the fluorescence intensity measurements from the separate membranes can, upon application of a standard curve indicate the relative nanoparticle concentration and thus the efficacy of the purification steps against the target live virus equivalent.
In one embodiment, there is provided an apparatus for ultra-low-dose (ULD) computed tomography (CT) reconstruction. The apparatus includes a low dimensional estimation neural network, and a high dimensional refinement neural network. The low dimensional estimation neural network is configured to receive sparse sinogram data, and to reconstruct a low dimensional estimated image based, at least in part, on the sparse sinogram data. The high dimensional refinement neural network is configured to receive the sparse sinogram data and intermediate image data, and to reconstruct a relatively high resolution CT image data. The intermediate image data is related to the low dimensional estimated image.
G06T 3/4046 - Changement d'échelle d’images complètes ou de parties d’image, p. ex. agrandissement ou rétrécissement utilisant des réseaux neuronaux
G06T 3/4053 - Changement d'échelle d’images complètes ou de parties d’image, p. ex. agrandissement ou rétrécissement basé sur la super-résolution, c.-à-d. où la résolution de l’image obtenue est plus élevée que la résolution du capteur
In an embodiment, there is provided a method for determining a spacecraft instantaneous velocity using starlight. The method includes determining, by a star pairing module, a plurality of star pairs in a selected star field image. The selected star field image includes a plurality of star images. The method includes estimating, by a line of sight estimation module, an apparent bearing direction to each star in at least some of the plurality of star pairs; determining, by the line of sight estimation module, a respective apparent inter-star angle for each star pair of the least some star pairs; and estimating, by a velocity estimation module, a spacecraft velocity to within a total velocity error based, at least in part, on the apparent inter-star angles.
G06T 7/246 - Analyse du mouvement utilisant des procédés basés sur les caractéristiques, p. ex. le suivi des coins ou des segments
B64G 1/36 - Appareils de guidage ou de commande, p. ex. de commande d'assiette par des capteurs, p. ex. par des capteurs solaires, des capteurs d'horizon
G01C 21/02 - NavigationInstruments de navigation non prévus dans les groupes par des moyens astronomiques
G01C 21/24 - NavigationInstruments de navigation non prévus dans les groupes spécialement adaptés pour la navigation des cosmonautes
85.
Thermally stable hydrocarbon-based anion exchange membrane and ionomers
An anion exchange membrane is composed of a copolymer of 1,1-diphenylethylene and one or more styrene monomers, such as 4-tert-butylstyrene. The copolymer includes a backbone substituted with a plurality of ionic groups coupled to phenyl groups on the backbone via hydrocarbyl tethers between about 1 and about 7 carbons in length. High-temperature conditions enabled by these copolymers enhance conductivity performance, making them particularly suitable for use in anion exchange membranes in fuel cells, electrolyzers employing hydrogen, ion separations, etc. The properties of the membranes can be tuned via the degree of functionalization of the phenyl groups and selection of the functional groups, such as quaternary ammonium groups. Several processes can be used to incorporate the desired ionic functional groups into the polymers, such as chloromethylation, radical bromination, Friedel-Crafts acylation and alkylation, sulfonation followed by amination, or combinations thereof.
The electrochemical energy conversion system include an anode, a cathode, and a proton exchange membrane disposed between the anode and the cathode. The proton exchange membrane includes a polymer having a hard block polymer, a soft block polymer, and one or more hydrophilic functional groups attached to the soft block polymer. The glass transition temperature of the hard block polymer is higher than a glass transition temperature of the soft block polymer, such that the hard block polymer is non-elastic and the soft block polymer is elastic at a desired operating temperature. The hydrophilic functional groups are attached to the soft block polymer via a thiol-ene reaction to modify double bonds in the soft block polymer. The swellable functional groups are selectively connected to the soft domains of the block copolymers, so that when the membrane swells (under hydration or gas adsorption), the stress is effectively absorbed by the soft domain and the impact on overall mechanical properties is minor, resulting in more durable membranes.
C08L 53/02 - Compositions contenant des copolymères séquencés possédant au moins une séquence d'un polymère obtenu par des réactions ne faisant intervenir que des liaisons non saturées carbone-carboneCompositions contenant des dérivés de tels polymères contenant des monomères vinylaromatiques et des diènes conjugués
H01M 8/1023 - Matériaux d’électrolyte polymère caractérisés par la structure chimique de la chaîne principale du polymère conducteur ionique comprenant uniquement du carbone, p. ex. des polyarylènes, des polystyrènes ou des polybutadiène-styrènes
H01M 8/1072 - Matériaux d’électrolyte polymère caractérisés par le procédé de fabrication par des réactions chimiques, p. ex. polymérisation in situ ou réticulation in situ
H01M 8/1088 - Modification chimique, p. ex. sulfonation
H01M 8/10 - Éléments à combustible avec électrolytes solides
87.
Alkaline anion exchange membranes derived from diphenylethylene and co-monomer feedstock
The anion exchange membranes exhibit enhanced chemical stability and ion conductivity when compared with traditional styrene-based alkaline anion exchange membranes. A copolymer backbone is polymerized from a reaction medium that includes a diphenylalkylene and an alkadiene. The copolymer includes a plurality of pendant phenyl groups. The diphenyl groups on the polymer backbone are functionalized with one or more haloalkylated precursor substrates. The terminal halide from the precursor substrate can then be substituted with a desired ionic group. The diphenylethylene-based alkaline anion exchange membranes lack the α-hydrogens sharing tertiary carbons with phenyl groups from polystyrene or styrene-based precursor polymers, resulting in higher chemical stability. The ionic groups are also apart from each other by about 3 to 6 carbons in the polymer backbone, enhancing ion conductivity. These membrane are advantageous for use in fuel cells, electrolyzers employing hydrogen, ion separations, etc.
B01J 41/14 - Composés macromoléculaires obtenus par des réactions ne faisant intervenir que des liaisons carbone-carbone non saturées
B01J 47/12 - Procédés d'échange d'ions en généralAppareillage à cet effet caractérisés par l'emploi d'une substance échangeur d'ions sous forme de rubans, de filaments, de fibres ou de feuilles, p. ex. sous forme de membranes
C02F 1/469 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par des procédés électrochimiques par séparation électrochimique, p. ex. par électro-osmose, électrodialyse, électrophorèse
C08F 212/32 - Monomères contenant un seul radical aliphatique non saturé contenant plusieurs cycles
A membrane for separating organic solvents such as methanol and toluene is provided. A plurality methacrylate polymer brushes, e.g., composed of hydroxy ethyl methacrylate (HEMA) monomers, are grafted from a crosslinked polyimide support using Single Electron Transfer- Living Radical Polymerization (SET-LRP). The polymer brushes themselves are also crosslinked by ethylene glycol dimethacrylate (EGDMA) and/or triethylene glycol dimethacryalte (TEGDMA). These hydrophilic polymeric brush membranes demonstrate pore stiffening and yet also opening, obtaining high selectivity at reasonable permeability and reduced energy requirements for commercially relevant separations, e.g., methanol/toluene. The addition of the crosslinker prevents loss of selectivity as a result of imparting increased rigidity, enabling the membranes to be operated at higher operating pressures for increased throughput. These membranes would be beneficial for use in pharmaceutical, chemical, petroleum, food, and biotechnology industries, e.g., in the manufacture of polymethacrylic acid, the manufacture of paraxylene, etc.
B01D 53/22 - Séparation de gaz ou de vapeursRécupération de vapeurs de solvants volatils dans les gazÉpuration chimique ou biologique des gaz résiduaires, p. ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par diffusion
A hollow-lid tube is provided with a body extending along a longitudinal axis and a lid configured to fit thereon. A seal is positioned within the tube to align a cavity within the body with one or more holes in the lid, and prevent a sample from escaping the cavity other than by those holes. Additionally, a membrane is positioned to separate the volume of the cavity and an environment surrounding the hollow-lid tube, for example by positioning the membrane within the hole itself, between the body and the lid, on the lid over the hole, etc. Samples to be tested or treated can be provided to a plurality of these tubes and subsequently positioned within a testing solution such that the sample and the solution each contact the membrane. Thus, simultaneous testing and/or assaying of one or more samples can be performed, greatly reducing analysis time and material costs.
In an embodiment, there is provided an apparatus. The apparatus includes an optic configured for a selected illumination application. The optic includes a first lens structure and a second lens structure. The first lens structure includes a first planar external surface configured to receive incident light, and a first internal nonplanar refractive surface opposing the first planar external surface. The second lens structure includes a second planar external surface configured to emit output light, and a second internal nonplanar refractive surface opposing the second planar external surface. The second planar external surface opposes the first planar external surface. The first internal nonplanar refractive surface and the second internal nonplanar refractive surface define a cavity. The first internal nonplanar refractive surface, the second internal nonplanar refractive surface, and the cavity are positioned between the first planar external surface and the second planar external surface. The first internal nonplanar refractive surface and the second internal nonplanar refractive surface are configured to refract received light to yield emitted light having a target output parameter corresponding to the selected illumination application.
Systems and techniques that facilitate reprogrammable federated learning are provided. In various embodiments, a server device can share a pre-trained and frozen neural network with a set of client devices. In various aspects, the server device can orchestrate reprogrammable federated learning of the pre-trained and frozen neural network among the set of client devices. In various instances, the pre-trained and frozen neural network can be positioned between at least one trainable input layer and at least one trainable output layer, and the reprogrammable federated learning can involve the at least one trainable input layer and the at least one trainable output layer, but not the pre-trained and frozen neural network, being locally adjusted by the set of client devices.
One embodiment provides a building material element. The building material element includes a three-dimensional (3D)-printed architectural element, and an integrated functional feature related to a functional element.
E04C 2/52 - Éléments de construction de relativement faible épaisseur pour la construction de parties de bâtiments, p. ex. matériaux en feuilles, dalles ou panneaux caractérisés par la forme ou la structure avec adaptations particulières pour usages auxiliaires, p. ex. servant au logement de conduits
B33Y 80/00 - Produits obtenus par fabrication additive
Systems and techniques that facilitate feature selection in vertical federated learning are provided. For example, one or more embodiments described herein can comprise a system, which can comprise a memory that can store computer executable components. The system can also comprise a processor, operably coupled to the memory that can execute the computer executable components stored in memory. The computer executable components can comprise an aggregator machine learning model that aggregates a plurality of embedding components from one or more local machine learning models and removes one or more embedding components based on minimizing weights at an input layer of the aggregator machine learning model.
The embodiments described herein are directed to various non-linear electrical devices in which charge flow is confined to two dimensions, so the charge flow occurs in what is called a two-dimensional system (2DS) or a two-dimensional electron system (2DES). A 2DS or 2DES can either exist in a natively two-dimensional material, such as graphene, potentially sandwiched between other materials, or in a quantum well sandwiched in semiconductor layers (e.g., a semiconductor heterostructure). A 2DS or 2DES can also be contained in certain threedimensional materials that enforce a predominantly two-dimensional charge flow. The devices exploit the non-linearity in current-voltage characteristics due to electron-electron interactions, either in the electronic ballistic or hydrodynamic transport regimes. The strength of the nonlinearity depends on the device geometry imposed on the 2DS or 2DES.
H01L 29/778 - Transistors à effet de champ avec un canal à gaz de porteurs de charge à deux dimensions, p.ex. transistors à effet de champ à haute mobilité électronique HEMT
B82Y 10/00 - Nanotechnologie pour le traitement, le stockage ou la transmission d’informations, p. ex. calcul quantique ou logique à un électron
H01L 29/06 - Corps semi-conducteurs caractérisés par les formes, les dimensions relatives, ou les dispositions des régions semi-conductrices
One embodiment provides a computing device. The computing device is configured to couple to a display. The computing device includes an ambient detection module configured to detect a characteristic of ambient light relative to at least a portion of a display area of the display. The computing device further includes a displayed image optimization module configured to optimize a feature of at least a portion of a displayed image based, at least in part, on the characteristic of the ambient light.
G09G 5/00 - Dispositions ou circuits de commande de l'affichage communs à l'affichage utilisant des tubes à rayons cathodiques et à l'affichage utilisant d'autres moyens de visualisation
G06F 3/14 - Sortie numérique vers un dispositif de visualisation
G09G 3/32 - Dispositions ou circuits de commande présentant un intérêt uniquement pour l'affichage utilisant des moyens de visualisation autres que les tubes à rayons cathodiques pour la présentation d'un ensemble de plusieurs caractères, p. ex. d'une page, en composant l'ensemble par combinaison d'éléments individuels disposés en matrice utilisant des sources lumineuses commandées utilisant des panneaux électroluminescents semi-conducteurs, p. ex. utilisant des diodes électroluminescentes [LED]
96.
ASSAY FOR FILTRATION OF SUSPENDED PARTICLES IN MICROPOROUS MEMBRANES
A method of assessing a membrane includes calculating fluid dynamic characteristics of at least one of a membrane and a material to be passed through the membrane, the membrane includes a plurality of rows and a plurality of teardrop structures arranged in the plurality of rows, the material includes particles; obtaining characteristic of at least one force acting on the particles of the material to be passed through the membrane due to the interaction between the particles and the membrane, the at least one force being an intermolecular force; and combining the calculated fluid dynamic characteristic and the obtained characteristics to assess the flow of the material through the membrane. In some embodiments, the teardrop structures in each row are arranged at substantially the same angle with respect to an anticipated direction of flow through the membrane.
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétésProcédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques
G01N 15/08 - Recherche de la perméabilité, du volume des pores ou de l'aire superficielle des matériaux poreux
A footwear system includes an upper portion, a sole portion, and an adjustable heel. The adjustable heel includes a top section configured to the sole portion at a top surface of the top section. The top section defines a top section vertical cavity, a top section upper horizontal cavity, and a top section lower horizontal cavity. A movable top locking pin is positioned at least partially within the top section upper horizontal cavity. A bottom section is coupled to the top section and configured to extend beyond the bottom surface of the top section when extended and to be contained at least partially within the top section vertical cavity when retracted. A movable spring-loaded locking pin is positioned at least partially within a bottom section upper horizontal cavity. The spring-loaded locking pin is configured to hold the bottom section in an extended or retracted position.
A chip system is provided that includes a micropillar chip and a corresponding microwell chip. The micropillars are coated with an anchoring layer, e.g., polydopamine/polylysine/fibronectin, which anchors an amount of a hydrogel composition to the micropillars, the composition including a matrix and a concentration of cancer cells, such as those from a particular patient. Upon gelation, the composition forms a three-dimensional structure with a high cancer cell density mimicking a tumor microenvironment, e.g., allows culturing of the cancer cells in hypoxic conditions representative of the conditions at the patient's tumor. The 3D structures of composition on the micropillars are then stamped into corresponding microwells including media composed of a variety of treatments for testing against the cancer cells. The media can include immune cells, enabling co-culture of the cancer cells with the immune cells to test for immune cell-mediated cytotoxicity, as well as combinations of drug and antibody based therapies.
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
C12M 1/32 - Inoculateur ou échantillonneur du type à champs multiples ou en continu
C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus
C12N 5/0783 - Cellules TCellules NKProgéniteurs de cellules T ou NK
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
clothing, namely, shirts, jackets and sweaters Educational services, namely, providing courses of instruction at the college level and distribution of course material in connection therewith
One embodiment provides an apparatus for fluorescence lifetime imaging (FLI). The apparatus includes a deep neural network (DNN). The DNN includes a first convolutional layer, a plurality of intermediate layers and an output layer. The first convolutional layer is configured to receive FLI input data. Each intermediate layer is configured to receive a respective intermediate input corresponding to an output of a respective prior layer. Each intermediate layer is further configured to provide a respective intermediate output related to the received respective intermediate input. The output layer is configured to provide estimated FLI output data corresponding to the received FLI input data. The DNN is trained using synthetic data.
