Abstract

The present disclosure relates to processes for preparing functionalized cyclooctenes and the synthetic intermediates prepared thereby.

IPC Classes  ?

• C07C 51/47 - SeparationPurificationStabilisationUse of additives by solid-liquid treatmentSeparationPurificationStabilisationUse of additives by chemisorption
• A61K 31/704 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
• A61K 38/07 - Tetrapeptides
• A61K 38/14 - Peptides containing saccharide radicalsDerivatives thereof
• A61K 38/15 - DepsipeptidesDerivatives thereof
• A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
• C07C 61/26 - Unsaturated compounds having a carboxyl group bound to a seven- to twelve-membered ring
• C07C 62/30 - Unsaturated compounds
• C07C 62/32 - Unsaturated compounds containing hydroxy or O-metal groups
• C07C 67/327 - Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by splitting-off hydrogen or functional groupsPreparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by hydrogenolysis of functional groups by elimination of functional groups containing oxygen only in singly bound form
• C07D 207/46 - Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
• C07D 311/94 - Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
• C07D 493/08 - Bridged systems

Abstract

A method of preparing a composition for use as a cathode that combines two different cathode materials is disclosed. When utilized in a battery, one cathode material is rechargeable, and the second cathode material has a high capacity with a lower voltage than the first cathode material. The active materials may be combined in several fashions including mixing, layering, deposition, coating, and/or patterning. Such batteries can be tested repeatedly over a specific voltage range and provide high capacity under full discharge at deployment.

IPC Classes  ?

• H01M 4/525 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of nickel, cobalt or iron of mixed oxides or hydroxides containing iron, cobalt or nickel for inserting or intercalating light metals, e.g. LiNiO2, LiCoO2 or LiCoOxFy
• H01M 4/02 - Electrodes composed of, or comprising, active material
• H01M 4/52 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of nickel, cobalt or iron
• H01M 4/58 - Selection of substances as active materials, active masses, active liquids of inorganic compounds other than oxides or hydroxides, e.g. sulfides, selenides, tellurides, halogenides or LiCoFySelection of substances as active materials, active masses, active liquids of polyanionic structures, e.g. phosphates, silicates or borates
• H01M 4/583 - Carbonaceous material, e.g. graphite-intercalation compounds or CFx

Abstract

A cancer vaccine technology is provided which knocks out expression of cell surface immune checkpoint proteins, to facilitate their processing by immune cells, and optionally by knocking-in the expression of cytokines to boost immune response. Non-replicating tumor cells lacking cell surface CD47 are highly effective immunizing agents against subcutaneous mouse melanoma. Whole-cell vaccines inhibited tumor growth, and immunophenotyping showed a dramatic increase in activated effector cell subsets and M1-type macrophages aided by a significant reduction in the tumor-associated macrophage and myeloid derived suppressor cell compartments. A remarkable downregulation of cell surface CD47 was observed in the tumors that did escape after vaccination with genetically modified cells, suggesting the intricate involvement of CD47 in a prophylactic situation. An effective vaccination strategy to increase tumor-specific immune response in solid tumors is provided to improve the outcome of cancer immunotherapy.

IPC Classes  ?

• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• C12N 5/09 - Tumour cells

Abstract

Provided is a method for treating and reducing the recurrence of genital tract infections such as gonococcal infections. The method comprises local application of IL-12 incorporated in polymeric microspheres. A method is also provided to reduce the incidence of genital tract infections caused by N. gonorrhoeae by administration of outer membrane vesicle preparations from N. gonorrhoeae and IL-12 incorporated in polymeric microspheres.

IPC Classes  ?

• A61K 38/20 - Interleukins

Abstract

Provided is a method for treating and reducing the recurrence of genital tract infections such as gonococcal infections. The method comprises local application of IL-12 incorporated in polymeric microspheres. A method is also provided to reduce the incidence of genital tract infections caused by N. gonorrhoeae by administration of outer membrane vesicle preparations from N. gonorrhoeae and IL-12 incorporated in polymeric microspheres.

IPC Classes  ?

• A61K 38/20 - Interleukins

Abstract

A system and method of scheduling tasks, comprising receiving activity and performance data from registers or storage locations maintained by hardware and an operating system; storing calibration coefficients associated with the activity and performance data; computing an energy dissipation rate based on at least the activity and performance data; and scheduling tasks under the operating system based on the computed energy dissipation rate.

IPC Classes  ?

• G06F 13/00 - Interconnection of, or transfer of information or other signals between, memories, input/output devices or central processing units
• G06F 1/32 - Means for saving power
• G06F 13/40 - Bus structure
• H04L 29/06 - Communication control; Communication processing characterised by a protocol
• H04L 29/08 - Transmission control procedure, e.g. data link level control procedure
• G06F 1/20 - Cooling means
• G06F 9/50 - Allocation of resources, e.g. of the central processing unit [CPU]
• G06F 9/48 - Program initiatingProgram switching, e.g. by interrupt

Abstract

Aspergillus species, such as by positron emission tomography (PET) scanning. In some examples, the disclosed compounds have a formula of 68Ga),1,4,7,10-tetraazacyclododecane-tetraacetic acid (DOTA) or 1,4,7-triazacyclononane-triacetic acid (NOTA).

IPC Classes  ?

• C07D 251/68 - Triazinylamino stilbenes
• A61K 31/53 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
• A61K 51/04 - Organic compounds
• A61P 31/10 - Antimycotics
• C07B 59/00 - Introduction of isotopes of elements into organic compounds

Abstract

Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.

IPC Classes  ?

• C07K 14/20 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
• A61K 39/02 - Bacterial antigens
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

Disclosed herein are isotopically labeled calcofluor derivatives and uses of such to detect fungi, such as filamentous fungi, including Aspergillus species, such as by positron emission tomography (PET) scanning. In some examples, the disclosed compounds have a formula of (I) wherein R1 is an amine, a hydroxyl group, a sulfide, a carboxylic acid, an amide, an alkyl, or aryl; R2 is -NHC(O)-R3-L or -C(O)NH-R3-L, wherein R3 is an aryl or an aliphatic group (such as alkyl); each R4 independently may be selected from halogen, aliphatic (such as alkyl), aryl, amine, hydroxyl, haloalkyl, carboxylic acid, amide, aralkyl, cyano, ester, thiol, thioether, or alkoxy; each R5 independently may be selected from hydrogen, aralkyl, alkyl, or aryl, with any one of the aralkyl, alkyl, or aryl groups optionally being substituted with any one of the substituents provided for R4; each n independently is 1, 2, 3, 4, or 5; and L is 18F or a chelator capable of chelating a radiolabel (such as chelators for [18F]A1F, 64Cu, 68Ga), 1,4,7,10- tetraazacyclododecane-tetraacetic acid (DOTA) or 1,4,7-triazacyclononane-triacetic acid (NOTA).

IPC Classes  ?

• C07D 251/68 - Triazinylamino stilbenes
• A61K 51/04 - Organic compounds

Abstract

The subject matter disclosed herein pertains to a method for screening drugs using second-harmonic generation microscopy. The tissue is scanned with a pulsed laser light which has an excitation wavelength. At least some of microtubules within the tissue produce generated light with a second-harmonic wavelength that is half the excitation wavelength. A microtubule pattern within the tissue is determined based on an analysis of the generated second-harmonic wavelength.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• G01J 9/00 - Measuring optical phase differenceDetermining degree of coherenceMeasuring optical wavelength
• G01J 4/00 - Measuring polarisation of light
• G01N 33/483 - Physical analysis of biological material
• G01N 21/63 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
• G01N 21/17 - Systems in which incident light is modified in accordance with the properties of the material investigated
• G01N 21/21 - Polarisation-affecting properties
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
• G02B 21/00 - Microscopes

Abstract

Disclosed is a radio frequency (RF) power calorimeter having a load electrically coupled to a RF input, a variable low-frequency power source electrically coupled to the load and configured to apply low-frequency bias to the load. The RF power calorimeter includes a thermal medium thermally coupled to the load. Additionally, the RF power calorimeter includes an outlet temperature sensor thermally coupled to the thermal medium, the outlet temperature sensor being positioned to measure the temperature of the thermal medium due to heating by the load. The RF power calorimeter also has circuitry configured to use temperature measurements of the thermal medium in thermal contact with an RF load in combination with the low-frequency bias to measure average power of an RF source electrically coupled to the RF input. Also disclosed in a method of measuring RF power using the RF power calorimeter.

IPC Classes  ?

• G01K 17/00 - Measuring quantity of heat

Abstract

Peptide nucleic acids containing thymidine and 2-aminopyridine (M) nucleobases formed stable and sequence selective triple helices with double stranded RNA at physiologically relevant conditions. The M-modified PNA displayed unique RNA selectivity by having two orders of magnitude higher affinity for the double stranded RNAs than for the same DNA sequences. Preliminary results suggested that nucleobase-modified PNA could bind and recognize double helical precursors of microRNAs.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• C12Q 1/6839 - Triple helix formation or other higher order conformations in hybridisation assays
• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
• C07K 9/00 - Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequenceDerivatives thereof

Abstract

Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.

IPC Classes  ?

• C07K 14/20 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
• A61K 39/02 - Bacterial antigens

Abstract

Fluorescent compositions with enhanced fluorescent intensity are provided. Methods for using the fluorescent compositions in medical imaging are also provided. The enhanced fluorescent compositions can be a mixture or solution comprising a fluorescent dye and a light-scattering emulsion or fluorescence-enhancing diluent. The fluorescent dye, e.g., indocyanine green (ICG), is activated by near-infrared radiation. The fluorescence-enhancing diluent can be milk, infant formula, intravenous fat emulsions, soy bean oil, egg phospholipids, Intralipid, Liposyn, Nutralipid, Soyacal, Travamulsion, SMOFlipid, Clinoleic, Lipovenoes and/or combinations thereof. The fluorescent intensity of the enhanced fluorescent composition can be 5 to 20 or more times greater than that of the fluorescent dye in solution without added fluorescence-enhancing diluent.

IPC Classes  ?

• C09K 11/02 - Use of particular materials as binders, particle coatings or suspension media therefor
• A61K 49/00 - Preparations for testing in vivo
• A61K 49/08 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by the carrier
• C09B 67/46 - Dispersions

Abstract

A optical control sensor system includes a driver controlling an operation of a light source coupled to an end of an optical fiber, an orthogonal signal generator, generating a set of different orthogonal signals controlling the driver, a terminal sensor coupled to another end of the optical fiber selecting a predetermined set of input orthogonal signals for converting them into component combinations, constituting output signals, and directing the output signals back to the optical fiber, a device coupled to the light sources and to the first end of the optical fiber for extracting output signals that have passed through a return path in the optical fiber, a detector converting optical output signals into electrical signals, and a selector and a decoder connected to the orthogonal signal generator indicating a current state of the optical control sensor system based on an analysis of the selected combinations of components in the output signals.

IPC Classes  ?

• G01J 1/42 - Photometry, e.g. photographic exposure meter using electric radiation detectors
• G01D 5/26 - Mechanical means for transferring the output of a sensing memberMeans for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for convertingTransducers not specially adapted for a specific variable using optical means, i.e. using infrared, visible or ultraviolet light
• H04J 14/02 - Wavelength-division multiplex systems
• H05B 37/02 - Controlling

Abstract

An omnibus process of pulping and bleaching lignocellulosic materials in which a charge of a lignocellulosic material is biopulped and/or water extracted prior to pulping and bleaching. The lignocellulosic material may be mechanically pulped and bleached in the presence of an enzyme that breaks lignin-carbohydrate complexes. The aqueous extract in embodiments including a water extract step is separated into acetic acid and hemicellulose sugar aqueous solutions.

IPC Classes  ?

• D21C 3/02 - Pulping cellulose-containing materials with inorganic bases or alkaline reacting compounds, e.g. sulfate processes
• D21C 3/26 - Multi-stage processes
• D21C 1/02 - Pretreatment of the finely-divided materials before digesting with water or steam
• D21C 3/22 - Other features of pulping processes
• D21C 11/00 - Regeneration of pulp liquors
• D21H 11/02 - Chemical or chemomechanical pulp
• D21H 11/08 - Mechanical or thermomechanical pulp
• D21H 11/10 - Mixtures of chemical and mechanical pulp

Abstract

An apparatus and method for non-invasive monitoring and detection of sudden changes in cardiovascular hemodynamics, in which a PPG signal is obtained from a patient, a time-frequency spectrum (TFS) is computed from the PPG signal, instantaneous modulations at a plurality of time points defining a curve of a prominent frequency of oscillation are extracted from the TFS, a peak power spectral density sequence is computed using the instantaneous modulations, and instantaneous peak values for following prominent frequency oscillations are monitored.

IPC Classes  ?

• A61B 5/02 - Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
• A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• A61B 5/024 - Measuring pulse rate or heart rate
• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
• A61B 5/021 - Measuring pressure in heart or blood vessels
• A61B 5/08 - Measuring devices for evaluating the respiratory organs
• A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters

Abstract

A method of treating a pulmonary disease such as, for instance idiopathic pulmonary fibrosis (IPF), mixed connective tissue disease and asthma, comprising administering an aerosolized interferon such as interferon γ in a therapeutically effective amount is provided herein. Also, pharmaceutical compositions of one or more aerosolized interferon(s) alone or in combination with other therapeutic agents are provided.

IPC Classes  ?

• A61K 38/00 - Medicinal preparations containing peptides
• A61K 38/21 - Interferons
• C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof

Abstract

A high flux and low pressure drop microfiltration (MF) membrane and a method for making the MF membrane. The microfiltration membranes are formed by a method that includes: preparing a nanofibrous structure; and modifying the surface of the nanofibrous structure with a surface modifier. The nanofibrous structure includes an electrospun nanofibrous scaffold or a polysaccharide nanofiber infused nanoscaffold or mixtures thereof. The electrospun nanofibrous scaffold can include polyacrylonitrile (PAN) or polyethersulfone (PES))/polyethylene terephthalate (PET) or mixtures thereof. The surface modifier includes polyethylenimine (PEI) and polyvinyl amine (Lupamin) cross-linked by ethylene glycol diglycidyl ether (EGdGE)/glycidyltrimethylammonium chloride (GTMAC1) or poly(l-(l- vinylimidazolium)ethyl-3-vinylimdazolium dibromide (VEVIMIBr).

IPC Classes  ?

• B01D 71/06 - Organic material

Abstract

CD155 tumors) expressing CD155, the poliovirus receptor, and is effective for oncolytic treatment and cure of solid tumors, such as neuroblastoma.

IPC Classes  ?

• A61K 39/12 - Viral antigens
• C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof
• A61K 35/76 - VirusesSubviral particlesBacteriophages

Abstract

A method for determining a sentiment associated with an entity includes inputting a plurality of texts associated with the entity, labeling seed words in the plurality of texts as positive or negative, determining a score estimate for the plurality of words based on the labeling, re-enumerating paths of the plurality of words and determining a number of sentiment alternations, determining a final score for the plurality of words using only paths whose number of alternations is within a threshold, converting the final scores to corresponding z-scores for each of the plurality of words, and outputting the sentiment associated with the entity.

IPC Classes  ?

• G06F 17/27 - Automatic analysis, e.g. parsing, orthograph correction

Abstract

A optical control sensor system includes a driver (102) controlling operation of a light source (103) coupled to an end of an optical fiber (105), an orthogonal signal generator (101), generating a set of different orthogonal signals controlling the driver, a terminal sensor (104) coupled to another end of the optical fiber selecting a predetermined set of input orthogonal signals for converting them into component combinations, constituting output signals, and directing the output signals back to the optical fiber, a device (108) coupled to the light sources and to the first end of the optical fiber for extracting output signals that have passed through a return path in the optical fiber, a detector (109) converting optical output signals into electrical signals, and a selector (110) and a decoder (111) connected to the orthogonal signal generator indicating a current state of the optical control sensor system.

IPC Classes  ?

• G02B 6/00 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings

Abstract

The invention relates to the development of chimeric OspA molecules for use in against Lyme disease or borreliosis vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with the distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies.

IPC Classes  ?

• A61K 39/02 - Bacterial antigens
• C07K 14/20 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira

Abstract

The present invention relates to SHIP inhibitor compounds and methods for using these compounds. In particular, the present invention discloses the following methods: (i) a method of treating graft versus host disease in a subject; (ii) a method of inhibiting a SHIP1 protein in a cell; (iii) a method of selectively inhibiting a SHIP1 protein in a cell; (iv) a method for treating or preventing graft-versus-host disease (GVHD) in a recipient of an organ or tissue transplant; (v) a method of modulating SHIP activity in a cell expressing SHIP1 or SHIP2; (vi) a method of ex vivo or in vitro treatment of transplants; (vii) a method of inhibiting tumor growth and metastasis in a subject; (viii) a method of treating a hematologic malignancy in a subject; (ix) a method of inducing apoptosis of multiple myeloma cells; (x) a method of treating multiple myeloma in a subject; (xi) a method of inhibiting the proliferation of a human breast cancer cell; and (xii) a method of treating breast cancer in a subject.

IPC Classes  ?

• C07C 401/00 - Irradiation products of cholesterol or its derivativesVitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
• A61K 31/565 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol
• A61K 31/575 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
• A61K 31/56 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids
• A61P 35/00 - Antineoplastic agents

Abstract

A method, system, and computer-readable medium for detecting a disease of a prostate. Exemplary embodiments of the present disclosure can include receiving an image dataset acquired with at least one acquisition mode; segmenting a region of interest including the prostate from the dataset; applying conformal mapping to map the region of interest to a canonical shape; generating a 3D visualization of the prostate using the canonically mapped dataset; and applying computer aided detection (CAD) to the canonically mapped volume to detect a region of disease of the organ.

IPC Classes  ?

• G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints

Abstract

The present invention relates to genetic analysis and evaluation utilizing copy-number variants or polymorphisms. The methods utilize array comparative genomic hybridization and PCR assays to identify the significance of copy number variations in a human or non-human animal subject or subject group.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• G06F 19/18 - for functional genomics or proteomics, e.g. genotype-phenotype associations, linkage disequilibrium, population genetics, binding site identification, mutagenesis, genotyping or genome annotation, protein-protein interactions or protein-nucleic acid interactions
• C12Q 1/6813 - Hybridisation assays

Abstract

The performance of a radio frequency identification (RFID) system is improved by a protocol that eliminates collisions between signals generated by a) RFID tags that the RFID reader has already identified as being in its interrogation zone and b) RFID tags that are newly arrived and thus that the reader has not yet identified. This is illustratively accomplished by the use of separate identification and access frames. It is during the identification frame that newly arrived tags become identified by the reader. Although there may be collisions during the identification frame, those collisions are only among newly arrived tags. The already-identified tags communicate with the reader during respective time slots of the access frame, so that they neither collide with each other nor with the newly arrived tags.

IPC Classes  ?

• H04Q 5/22 - Selecting arrangements wherein two or more subscriber stations are connected by the same line to the exchange with indirect connection, i.e. through subordinate switching centre the subordinate centre not permitting interconnection of subscribers connected thereto

Abstract

The invention relates to the field of polymers and olefin polymerization, and more specifically olefin metathesis polymerization. The invention provides regioregular alternating polymers and methods of synthesizing such polymers.

IPC Classes  ?

• C08F 4/44 - MetalsMetal hydridesMetallo-organic compoundsUse thereof as catalyst precursors selected from light metals, zinc, cadmium, mercury, copper, silver, gold, boron, gallium, indium, thallium, rare earths, or actinides

Abstract

Synthesis of nanoparticles with particle size control is provided by the method of using two different metal-containing precursors, a capping component, an optional reducing agent, and then contacting the two precursors with the capping component to form a reaction solution, which is heated to produce first and second metals-containing nanoparticles. By controlling the ratio of the concentration of the capping component to the total concentration of the two metal-containing precursors, the nanoparticles can have diameters ranging between about 1 nm to about 15 nm. A decrease in the concentration of the capping component typically increases the size of the nanoparticles. Preferred compositions include Pt and Co- containing alloy nanoparticles. Controlled synthesis of larger, about 6 nm to about 12 nm, sized nanoparticles can be achieved in a solvent-free reaction process.

IPC Classes  ?

• B22F 1/00 - Metallic powderTreatment of metallic powder, e.g. to facilitate working or to improve properties
• B22F 9/24 - Making metallic powder or suspensions thereofApparatus or devices specially adapted therefor using chemical processes with reduction of metal compounds starting from liquid metal compounds, e.g. solutions
• C22B 11/00 - Obtaining noble metals

Abstract

Synthesis of nanoparticles with particle size control is provided by the method of using two different metal-containing precursors, a capping component, an optional reducing agent, and then contacting the two precursors with the capping component to form a reaction solution, which is heated to produce first and second metals-containing nanoparticles. By controlling the ratio of the concentration of the capping component to the total concentration of the two metal-containing precursors, the nanoparticles can have diameters ranging between about 1 nm to about 15 nm. A decrease in the concentration of the capping component typically increases the size of the nanoparticles. Preferred compositions include Pt and Co-containing alloy nanoparticles. Controlled synthesis of larger, about 6 nm to about 12 nm, sized nanoparticles can be achieved in a solvent-free reaction process.

IPC Classes  ?

• B22F 9/18 - Making metallic powder or suspensions thereofApparatus or devices specially adapted therefor using chemical processes with reduction of metal compounds

Abstract

Method and apparatus are provided for automated determination and adjustment of height and tilt of a substrate surface within a lithography system. The method includes: directing a beam of light onto the substrate surface, which reflects off the substrate surface as a reflected beam; optically splitting the reflected beam into a first reflected beam portion and a second reflected beam portion; impinging the first reflected beam portion onto a first detector plane of a first optical detector to generate intensity data, and impinging the second reflected beam portion onto a second detector plane of a second optical detector to generate intensity data, and utilizing the generated data in determining height and tilt of the substrate surface relative to a nominal writing plane of the lithography system. Responsive to the determination, focus or tilt of the system's writing beam, or position of the substrate surface within the system, is adjusted.

IPC Classes  ?

• H01L 21/027 - Making masks on semiconductor bodies for further photolithographic processing, not provided for in group or
• H01L 21/68 - Apparatus specially adapted for handling semiconductor or electric solid state devices during manufacture or treatment thereofApparatus specially adapted for handling wafers during manufacture or treatment of semiconductor or electric solid state devices or components for positioning, orientation or alignment

Abstract

Disclosed is an apparatus and system for monitoring drug regimen compliance, the system utilizing a Radio Frequency Identification (RfID) tag affixed to a pharmaceutical agent and a wearable RFID reader that identifies a patient. The RFID tag identifies the pharmaceutical agent and the RFID reader wirelessly communicates with a central monitoring system upon ingestion of the pharmaceutical agent.

IPC Classes  ?

• G06Q 50/00 - Information and communication technology [ICT] specially adapted for implementation of business processes of specific business sectors, e.g. utilities or tourism

Abstract

Virtually augmented endoscopy includes overlaying optical endoscopy image data with a virtual endoscopy model. Image distortion in the optical endoscopy image data can be substantially reduced. Features in the virtual endoscopy model can be correlated with features in the optical endoscopy image data to improve examination performance. A correlation path through the virtual endoscopy model can be determined that reasonably follows the physical path of an endoscope. A 2D or 3D correlation model can be generated from the image data and correlated to the virtual endoscopy model. Correlation between the scan data domain and the image data domain can use either the correlation path, correlation model or a combination thereof. CAD tools and other features of virtual endoscopy can then be applied to enhance the performance of optical endoscopy.

IPC Classes  ?

• A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
• A61B 1/06 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements
• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging

Abstract

A method for fluorescence detection that provides control of experimental and molecular factors and reliably predicts of concentration from fluorescence intensity measurements utilizing capillary-based flow sensors utilizing a dual detector approach to provide instantaneous normalization of the fluorescent intensity by the Rayleigh scattered intensity measured from the same sensing volume, insensitive to various experimental parameters for prediction of absolute concentrations of fluorescent solutes.

IPC Classes  ?

• G01N 33/483 - Physical analysis of biological material

Abstract

A device, system, and method for isolating a ventilator from one or more patients in which the delivery conditions of gas delivered to an isolation device from a ventilator may drive the delivery of breathing-gas delivered to one or more patients, the breathing-gas having the same or different delivery conditions. In one embodiment, an isolation device may have a housing and a movable partition. The movable partition may be joined to the housing, The movable partition may have a patient side on a first side of the partition and an actuating side on a second side of the partition. The isolation device may include an inlet pressure regulator on the actuating side and/or an exhaust pressure regulator on the patient side. These regulators may alter the delivery conditions (including, but not limited to, pressure and volume) of breathing-gas delivered to a patient.

IPC Classes  ?

• A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes

Abstract

Disclosed is a method for storing digital information for storage in an adversarial setting in which trusted hardware enforces digital information compliance with data storage mandates. Secure storage overhead is minimized by identifying sparsely accessing the trusted hardware based on data retention cycles. Data retention assurances are provided for information stored by a Write-Once Read-Many (WORM) storage system.

IPC Classes  ?

• G06F 21/00 - Security arrangements for protecting computers, components thereof, programs or data against unauthorised activity
• G06F 15/16 - Combinations of two or more digital computers each having at least an arithmetic unit, a program unit and a register, e.g. for a simultaneous processing of several programs
• G06F 11/30 - Monitoring
• G06F 17/00 - Digital computing or data processing equipment or methods, specially adapted for specific functions

Abstract

A method of treating tuberculosis comprising administering an aerosolized interferon such as interferon α, interferon β or interferon &ggr; in a therapeutically effective amount is provided herein. Also, pharmaceutical compositions of one or more aerosolized interferon(s) are provided.

IPC Classes  ?

• C12P 21/04 - Cyclic or bridged peptides or polypeptides, e.g. bacitracin

Abstract

A method for determining a sentiment associated with an entity includes inputting a plurality of texts associated with the entity, labeling seed words in the plurality of texts as positive or negative (201), determining a score estimate for the plurality of words based on the labeling (203), re-enumerating paths of the plurality of words and determining a number of sentiment alternations (204), determining a final score for the plurality of words using only paths whose number of alternations is within a threshold (205), converting the final scores to corresponding z-scores for each of the plurality of words (207), and outputting the sentiment associated with the entity.

IPC Classes  ?

• G06F 17/27 - Automatic analysis, e.g. parsing, orthograph correction

Abstract

An improved method of treating periodontitis includes the steps of: creating a formulation containing a lanthanide-containing protease inhibitor; and applying the formulation to a periodontal area. The lanthanide may be cerium chloride, samarium chloride, lutetium chloride, cerium chloride heptahydrate, lutetium chloride hexahydrate, samarium chloride hexa- hydrate, gadolinium, gadolinium nitrate, gadolinium chloride, gadolinium chloride hexahydrate and gadolinium nitrate hexahydrate. The invention also provides an improved method of reducing dentinal sensitivity, including the steps of: creating a formulation containing at least one of gadolinium and a gadolinium-containing compound; and applying the formulation to a sensitive dentinal area. The formulation may be a paste, a solution or a powder.

IPC Classes  ?

• A61K 8/00 - Cosmetics or similar toiletry preparations

Abstract

The invention relates to the discovery that collagenase injections are effective in dissolving and lysing the collagenase septa network in the skin that comprises cellulite. As such, the invention relates to methods of treating cellulite in a patient in need of such treatment comprising injecting or otherwise delivering the effective amount of purified collagenase to the collagenase septa network of cellulite in the skin. The invention also relates to the use of collagenase in the manufacture of a medicament to treat cellulite of the skin.

IPC Classes  ?

• A61K 38/48 - Hydrolases (3) acting on peptide bonds (3.4)
• A61K 8/66 - Enzymes

Abstract

The present invention relates to methods and compositions for stimulating the proliferation of cardiomyocytes for enhancement of cardiac repair. The invention is based on. the discovery that upon contact with stem cells, or conditioned media derived from said stem cells, terminally differentiated cardiomyocytes can be stimulated to enter the cell cycle. Additionally, scaffolds capable of attracting stem cells to the area of implantation have been shown to induce cardiomyocyte proliferation. The present invention further relates to the discovery that the Wnt-5 A ligand, which binds to the frizzled receptor (fz), functions to stimulate cardiomyocyte proliferation. The methods and compositions of the invention may be used in the treatment of cardiac disorders including, but not limited to, myocardial dysfunction or infarction. The invention further relates to screening assays designed to identify compounds that modulate the proliferative activity of cardiomyocytes and the use of such compounds in the treatment of cardiac disorders.

IPC Classes  ?

• A61K 35/48 - Reproductive organs
• A61K 35/26 - LymphLymph nodesThymusSpleenSplenocytesThymocytes
• A61K 35/28 - Bone marrowHaematopoietic stem cellsMesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• A61K 38/18 - Growth factorsGrowth regulators
• A61K 38/48 - Hydrolases (3) acting on peptide bonds (3.4)
• A61L 27/38 - Animal cells
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• C12N 5/077 - Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

An omnibus process of pulping and bleaching lignocellulosic materials in which a charge of a lignocellulosic material is biopulped and/or water extracted prior to pulping and bleaching. The lignocellulosic material may be mechanically pulped and bleached in the presence of an enzyme that breaks lignin-carbohydrate complexes. The aqueous extract in embodiments including a water extract step is separated into acetic acid and hemicellulose sugar aqueous solutions.

IPC Classes  ?

• D21C 3/26 - Multi-stage processes
• D21C 3/02 - Pulping cellulose-containing materials with inorganic bases or alkaline reacting compounds, e.g. sulfate processes
• D21C 9/10 - Bleaching
• D21C 9/14 - Bleaching with halogens or halogen-containing compounds with ClO2 or chlorites
• D21C 9/147 - Bleaching with oxygen or its allotropic modifications
• D21C 9/153 - Bleaching with oxygen or its allotropic modifications with ozone

Abstract

This invention provides a chimeric hyperpolarization-activated, cyclic nucleotide-gated (HCN) polypeptide comprising portions of more than one type of HCN channel. The invention also provides methods of treating a subject afflicted with a cardiac rhythm disorder comprising expression of the chimeric HCN polypeptide in a selected region of the heart so as to induce a pacemaker current in the heart and thereby treat the subject.

IPC Classes  ?

• C12N 15/12 - Genes encoding animal proteins
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression
• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61K 35/12 - Materials from mammalsCompositions comprising non-specified tissues or cellsCompositions comprising non-embryonic stem cellsGenetically modified cells
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• C12P 21/02 - Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Abstract

This invention provides a bypass bridge comprising a tract of gap junction-coupled cells having a first end and a second end, both ends capable of being attached to two selected sites in a heart so as to allow the conduction of a pacemaker and/or electrical signal/current across the tract between the two sites, wherein the cells functionally express a sodium channel. The invention also provides related methods of making the bypass bridge, methods of implanting same in a heart, and methods of treating a disorder associated with an impaired conduction in a subject's heart.

IPC Classes  ?

• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• C12N 5/077 - Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
• C12N 5/0775 - Mesenchymal stem cellsAdipose-tissue derived stem cells

Abstract

This invention provides pacemaker systems comprising (1) an electronic pacemaker, and (2) a biological pacemaker, wherein the biological pacemaker comprises a cell that functionally expresses a chimeric hyperpolarization-activated, cyclic nucleotide-gated (HCN) ion channel at a level effective to induce pacemaker current in the cell. The invention also provides related biological pacemakers, atrioventricular bridges, methods of making same, and methods of treating a subject afflicted with a cardiac rhythm disorder.

IPC Classes  ?

• A61N 1/368 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential comprising more than one electrode co-operating with different heart regions
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy

Abstract

The present invention relates to inhibiting angiogenesis with sulfoxide containing compounds, and polymeric forms thereof, in mammals including animals and humans. Sulfoxide containing compounds, and polymeric forms thereof , can be used alone or in combination with standard therapies to inhibit angiogenesis-mediated disorders. The present invention also relates to the combined use of sulfoxide containing compounds, and polymeric forms thereof , with other anti-angiogenesis agents, with various anti- inflammatory and cytotoxic agents as well as with radio-therapeutic agents in cancer, and with laser, photodynamic therapy for ocular-related disorders such as diabetic retinopathy or age-related macular degeneration.

IPC Classes  ?

• A61K 31/10 - SulfidesSulfoxidesSulfones
• A61K 31/095 - Sulfur, selenium or tellurium compounds, e.g. thiols
• A61K 33/04 - Sulfur, selenium or telluriumCompounds thereof
• A61P 35/00 - Antineoplastic agents
• A61P 27/00 - Drugs for disorders of the senses

Abstract

A computer-implemented method for ranking a plurality of academic programs includes receiving a plurality of records corresponding to the plurality of academic programs, respectively, combining elements of the plurality of records to determine respective z-scores according to a predetermined metric, and ranking the plurality of academic programs according to the respective z-scores.

IPC Classes  ?

• G06N 5/00 - Computing arrangements using knowledge-based models

Abstract

A method for direct writing an electrically conductive metallic feature on an insulating substrate comprises creating a gas jet comprising metallic particles (301), ejecting the gas jet comprising metallic particles through a straight bore tube (302), and impacting the gas jet comprising metallic particles onto a substrate to impinge the metallic particles on the substrate to form the electrically conductive metallic feature (303).

IPC Classes  ?

• B05D 1/02 - Processes for applying liquids or other fluent materials performed by spraying
• B05D 5/12 - Processes for applying liquids or other fluent materials to surfaces to obtain special surface effects, finishes or structures to obtain a coating with specific electrical properties

Abstract

The present teachings are directed toward single metal and alloy nanoparticles and synthesis methods for preparing single metal and alloy nanoparticles.

IPC Classes  ?

• B22F 9/24 - Making metallic powder or suspensions thereofApparatus or devices specially adapted therefor using chemical processes with reduction of metal compounds starting from liquid metal compounds, e.g. solutions

Abstract

A seamless vertical handoff method allows the network applications and connections on a mobile node to continue without disruption as it moves within a wireless overlay network that comprises multiple possibly overlapping layers of wireless networks (e.g., a WLAN and a WWAN) with different underlying technologies, providing mobile roaming capabilities. The method comprises a WLAN access point signal strength monitor for determining when to switch between WLAN and WWAN, and a network connection migration scheme that can move an active network connection from a wireless link of one technology to another wireless link of a different technology in a way that is transparent to the user, the remote end of the network connection, and the operator of the WWAN carrier.

IPC Classes  ?

• H04Q 7/20 -

Abstract

A method for fabricating an electronic device comprises providing a substrate (501), direct writing a functional material by a thermal spray on the substrate (502) and removing a portion of the function material to form the electronic or sensory device (503).

IPC Classes  ?

• B23K 26/38 - Removing material by boring or cutting