Abrégé

The present disclosure relates to processes for preparing functionalized cyclooctenes and the synthetic intermediates prepared thereby.

Classes IPC  ?

• C07C 51/47 - SéparationPurificationStabilisationEmploi d'additifs par traitement solide-liquideSéparationPurificationStabilisationEmploi d'additifs par absorption-adsorption chimique
• A61K 31/704 - Composés ayant des radicaux saccharide liés à des composés non-saccharide par des liaisons glycosidiques liés à un composé carbocyclique, p. ex. phloridzine liés à un système carbocyclique condensé, p. ex. sennosides, thiocolchicosides, escine, daunorubicine, digitoxine
• A61K 38/07 - Tétrapeptides
• A61K 38/14 - Peptides contenant des radicaux saccharideLeurs dérivés
• A61K 38/15 - DepsipeptidesLeurs dérivés
• A61K 47/14 - Esters d’acides carboxyliques, p. ex. acides gras monoglycérides, triglycérides à chaine moyenne, parabènes ou esters d’acide gras de PEG
• C07C 61/26 - Composés non saturés comportant un groupe carboxyle lié à un cycle de sept à douze chaînons
• C07C 62/30 - Composés non saturés
• C07C 62/32 - Composés non saturés contenant des groupes hydroxyle ou O-métal
• C07C 67/327 - Préparation d'esters d'acides carboxyliques par modification de la partie acide de l'ester sans introduction d'un groupe ester par élimination d'hydrogène ou de groupes fonctionnelsPréparation d'esters d'acides carboxyliques par modification de la partie acide de l'ester sans introduction d'un groupe ester par hydrogénolyse de groupes fonctionnels par élimination de groupes fonctionnels contenant de l'oxygène lié uniquement par liaison simple
• C07D 207/46 - Composés hétérocycliques contenant des cycles à cinq chaînons, non condensés avec d'autres cycles, ne comportant qu'un atome d'azote comme unique hétéro-atome du cycle avec les hétéro-atomes liés directement à l'atome d'azote du cycle
• C07D 311/94 - Composés hétérocycliques contenant des cycles à six chaînons comportant un atome d'oxygène comme unique hétéro-atome du cycle, condensés avec d'autres cycles condensés en ortho ou en péri avec des carbocycles ou avec des systèmes carbocycliques condensés avec des cycles autres que des cycles à six chaînons ou avec des systèmes cycliques contenant de tels cycles
• C07D 493/08 - Systèmes pontés

Abrégé

A method of preparing a composition for use as a cathode that combines two different cathode materials is disclosed. When utilized in a battery, one cathode material is rechargeable, and the second cathode material has a high capacity with a lower voltage than the first cathode material. The active materials may be combined in several fashions including mixing, layering, deposition, coating, and/or patterning. Such batteries can be tested repeatedly over a specific voltage range and provide high capacity under full discharge at deployment.

Classes IPC  ?

• H01M 4/525 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs d'oxydes ou d'hydroxydes inorganiques de nickel, de cobalt ou de fer d'oxydes ou d'hydroxydes mixtes contenant du fer, du cobalt ou du nickel pour insérer ou intercaler des métaux légers, p. ex. LiNiO2, LiCoO2 ou LiCoOxFy
• H01M 4/02 - Électrodes composées d'un ou comprenant un matériau actif
• H01M 4/52 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs d'oxydes ou d'hydroxydes inorganiques de nickel, de cobalt ou de fer
• H01M 4/58 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs de composés inorganiques autres que les oxydes ou les hydroxydes, p. ex. sulfures, séléniures, tellurures, halogénures ou LiCoFyEmploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs de structures polyanioniques, p. ex. phosphates, silicates ou borates
• H01M 4/583 - Matériau carboné, p. ex. composés au graphite d'intercalation ou CFx

Abrégé

A cancer vaccine technology is provided which knocks out expression of cell surface immune checkpoint proteins, to facilitate their processing by immune cells, and optionally by knocking-in the expression of cytokines to boost immune response. Non-replicating tumor cells lacking cell surface CD47 are highly effective immunizing agents against subcutaneous mouse melanoma. Whole-cell vaccines inhibited tumor growth, and immunophenotyping showed a dramatic increase in activated effector cell subsets and M1-type macrophages aided by a significant reduction in the tumor-associated macrophage and myeloid derived suppressor cell compartments. A remarkable downregulation of cell surface CD47 was observed in the tumors that did escape after vaccination with genetically modified cells, suggesting the intricate involvement of CD47 in a prophylactic situation. An effective vaccination strategy to increase tumor-specific immune response in solid tumors is provided to improve the outcome of cancer immunotherapy.

Classes IPC  ?

• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• C12N 5/09 - Cellules tumorales

Abrégé

Provided is a method for treating and reducing the recurrence of genital tract infections such as gonococcal infections. The method comprises local application of IL-12 incorporated in polymeric microspheres. A method is also provided to reduce the incidence of genital tract infections caused by N. gonorrhoeae by administration of outer membrane vesicle preparations from N. gonorrhoeae and IL-12 incorporated in polymeric microspheres.

Classes IPC  ?

• A61K 38/20 - Interleukines

Abrégé

Provided is a method for treating and reducing the recurrence of genital tract infections such as gonococcal infections. The method comprises local application of IL-12 incorporated in polymeric microspheres. A method is also provided to reduce the incidence of genital tract infections caused by N. gonorrhoeae by administration of outer membrane vesicle preparations from N. gonorrhoeae and IL-12 incorporated in polymeric microspheres.

Classes IPC  ?

• A61K 38/20 - Interleukines

Abrégé

A system and method of scheduling tasks, comprising receiving activity and performance data from registers or storage locations maintained by hardware and an operating system; storing calibration coefficients associated with the activity and performance data; computing an energy dissipation rate based on at least the activity and performance data; and scheduling tasks under the operating system based on the computed energy dissipation rate.

Classes IPC  ?

• G06F 13/00 - Interconnexion ou transfert d'information ou d'autres signaux entre mémoires, dispositifs d'entrée/sortie ou unités de traitement
• G06F 1/32 - Moyens destinés à économiser de l'énergie
• G06F 13/40 - Structure du bus
• H04L 29/06 - Commande de la communication; Traitement de la communication caractérisés par un protocole
• H04L 29/08 - Procédure de commande de la transmission, p.ex. procédure de commande du niveau de la liaison
• G06F 1/20 - Moyens de refroidissement
• G06F 9/50 - Allocation de ressources, p. ex. de l'unité centrale de traitement [UCT]
• G06F 9/48 - Lancement de programmes Commutation de programmes, p. ex. par interruption

Abrégé

Aspergillus species, such as by positron emission tomography (PET) scanning. In some examples, the disclosed compounds have a formula of 68Ga),1,4,7,10-tetraazacyclododecane-tetraacetic acid (DOTA) or 1,4,7-triazacyclononane-triacetic acid (NOTA).

Classes IPC  ?

• C07D 251/68 - Triazinylaminostilbènes
• A61K 31/53 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec trois azote comme seuls hétéro-atomes d'un cycle, p. ex. chlorazanil, mélamine
• A61K 51/04 - Composés organiques
• A61P 31/10 - Antifongiques
• C07B 59/00 - Introduction d'isotopes d'éléments dans les composés organiques

Abrégé

Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.

Classes IPC  ?

• C07K 14/20 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries provenant de Spirochaetales (O), p. ex. Tréponème, Leptospira
• A61K 39/02 - Antigènes bactériens
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps

Abrégé

Disclosed herein are isotopically labeled calcofluor derivatives and uses of such to detect fungi, such as filamentous fungi, including Aspergillus species, such as by positron emission tomography (PET) scanning. In some examples, the disclosed compounds have a formula of (I) wherein R1 is an amine, a hydroxyl group, a sulfide, a carboxylic acid, an amide, an alkyl, or aryl; R2 is -NHC(O)-R3-L or -C(O)NH-R3-L, wherein R3 is an aryl or an aliphatic group (such as alkyl); each R4 independently may be selected from halogen, aliphatic (such as alkyl), aryl, amine, hydroxyl, haloalkyl, carboxylic acid, amide, aralkyl, cyano, ester, thiol, thioether, or alkoxy; each R5 independently may be selected from hydrogen, aralkyl, alkyl, or aryl, with any one of the aralkyl, alkyl, or aryl groups optionally being substituted with any one of the substituents provided for R4; each n independently is 1, 2, 3, 4, or 5; and L is 18F or a chelator capable of chelating a radiolabel (such as chelators for [18F]A1F, 64Cu, 68Ga), 1,4,7,10- tetraazacyclododecane-tetraacetic acid (DOTA) or 1,4,7-triazacyclononane-triacetic acid (NOTA).

Classes IPC  ?

• C07D 251/68 - Triazinylaminostilbènes
• A61K 51/04 - Composés organiques

Abrégé

The subject matter disclosed herein pertains to a method for screening drugs using second-harmonic generation microscopy. The tissue is scanned with a pulsed laser light which has an excitation wavelength. At least some of microtubules within the tissue produce generated light with a second-harmonic wavelength that is half the excitation wavelength. A microtubule pattern within the tissue is determined based on an analysis of the generated second-harmonic wavelength.

Classes IPC  ?

• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
• G01J 9/00 - Mesure du déphasage des rayons lumineuxRecherche du degré de cohérenceMesure de la longueur d'onde des rayons lumineux
• G01J 4/00 - Mesure de la polarisation de la lumière
• G01N 33/483 - Analyse physique de matériau biologique
• G01N 21/63 - Systèmes dans lesquels le matériau analysé est excité de façon à ce qu'il émette de la lumière ou qu'il produise un changement de la longueur d'onde de la lumière incidente excité optiquement
• G01N 21/17 - Systèmes dans lesquels la lumière incidente est modifiée suivant les propriétés du matériau examiné
• G01N 21/21 - Propriétés affectant la polarisation
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 3/10 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux du type à mesure objective, c.-à-d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient
• G02B 21/00 - Microscopes

Abrégé

Disclosed is a radio frequency (RF) power calorimeter having a load electrically coupled to a RF input, a variable low-frequency power source electrically coupled to the load and configured to apply low-frequency bias to the load. The RF power calorimeter includes a thermal medium thermally coupled to the load. Additionally, the RF power calorimeter includes an outlet temperature sensor thermally coupled to the thermal medium, the outlet temperature sensor being positioned to measure the temperature of the thermal medium due to heating by the load. The RF power calorimeter also has circuitry configured to use temperature measurements of the thermal medium in thermal contact with an RF load in combination with the low-frequency bias to measure average power of an RF source electrically coupled to the RF input. Also disclosed in a method of measuring RF power using the RF power calorimeter.

Classes IPC  ?

• G01K 17/00 - Mesure d'une quantité de chaleur

Abrégé

Peptide nucleic acids containing thymidine and 2-aminopyridine (M) nucleobases formed stable and sequence selective triple helices with double stranded RNA at physiologically relevant conditions. The M-modified PNA displayed unique RNA selectivity by having two orders of magnitude higher affinity for the double stranded RNAs than for the same DNA sequences. Preliminary results suggested that nucleobase-modified PNA could bind and recognize double helical precursors of microRNAs.

Classes IPC  ?

• C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
• C12Q 1/6839 - Formation de chaine hélicoïdale triple ou autres conformations supérieures dans les tests d’hybridation
• C07K 7/08 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 12 à 20 amino-acides
• C07K 9/00 - Peptides ayant jusqu'à 20 amino-acides, contenant des radicaux saccharide et comportant une séquence entièrement déterminéeLeurs dérivés

Abrégé

Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.

Classes IPC  ?

• C07K 14/20 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries provenant de Spirochaetales (O), p. ex. Tréponème, Leptospira
• A61K 39/02 - Antigènes bactériens

Abrégé

Fluorescent compositions with enhanced fluorescent intensity are provided. Methods for using the fluorescent compositions in medical imaging are also provided. The enhanced fluorescent compositions can be a mixture or solution comprising a fluorescent dye and a light-scattering emulsion or fluorescence-enhancing diluent. The fluorescent dye, e.g., indocyanine green (ICG), is activated by near-infrared radiation. The fluorescence-enhancing diluent can be milk, infant formula, intravenous fat emulsions, soy bean oil, egg phospholipids, Intralipid, Liposyn, Nutralipid, Soyacal, Travamulsion, SMOFlipid, Clinoleic, Lipovenoes and/or combinations thereof. The fluorescent intensity of the enhanced fluorescent composition can be 5 to 20 or more times greater than that of the fluorescent dye in solution without added fluorescence-enhancing diluent.

Classes IPC  ?

• C09K 11/02 - Emploi de substances particulières comme liants, revêtements de particules ou milieux de suspension
• A61K 49/00 - Préparations pour examen in vivo
• A61K 49/08 - Préparations de contraste pour la résonance magnétique nucléaire [RMN]Préparations de contraste pour l'imagerie par résonance magnétique [IRM] caractérisées par le support
• C09B 67/46 - Dispersions

Abrégé

A optical control sensor system includes a driver controlling an operation of a light source coupled to an end of an optical fiber, an orthogonal signal generator, generating a set of different orthogonal signals controlling the driver, a terminal sensor coupled to another end of the optical fiber selecting a predetermined set of input orthogonal signals for converting them into component combinations, constituting output signals, and directing the output signals back to the optical fiber, a device coupled to the light sources and to the first end of the optical fiber for extracting output signals that have passed through a return path in the optical fiber, a detector converting optical output signals into electrical signals, and a selector and a decoder connected to the orthogonal signal generator indicating a current state of the optical control sensor system based on an analysis of the selected combinations of components in the output signals.

Classes IPC  ?

• G01J 1/42 - Photométrie, p. ex. posemètres photographiques en utilisant des détecteurs électriques de radiations
• G01D 5/26 - Moyens mécaniques pour le transfert de la grandeur de sortie d'un organe sensibleMoyens pour convertir la grandeur de sortie d'un organe sensible en une autre variable, lorsque la forme ou la nature de l'organe sensible n'imposent pas un moyen de conversion déterminéTransducteurs non spécialement adaptés à une variable particulière utilisant des moyens optiques, c.-à-d. utilisant de la lumière infrarouge, visible ou ultraviolette
• H04J 14/02 - Systèmes multiplex à division de longueur d'onde
• H05B 37/02 - Commande

Abrégé

An omnibus process of pulping and bleaching lignocellulosic materials in which a charge of a lignocellulosic material is biopulped and/or water extracted prior to pulping and bleaching. The lignocellulosic material may be mechanically pulped and bleached in the presence of an enzyme that breaks lignin-carbohydrate complexes. The aqueous extract in embodiments including a water extract step is separated into acetic acid and hemicellulose sugar aqueous solutions.

Classes IPC  ?

• D21C 3/02 - Réduction en pâte des matières contenant de la cellulose avec des bases inorganiques ou des composés à réaction alcaline, p. ex. procédés au sulfate
• D21C 3/26 - Procédés à plusieurs stades
• D21C 1/02 - Traitement préalable des matériaux finement divisés avant la cuisson avec l'eau ou la vapeur
• D21C 3/22 - Autres caractéristiques des procédés de réduction en pâte
• D21C 11/00 - Régénération des liqueurs noires
• D21H 11/02 - Pâte chimique ou mi-chimique
• D21H 11/08 - Pâte mécanique ou thermomécanique
• D21H 11/10 - Mélanges de pâte chimique et mécanique

Abrégé

An apparatus and method for non-invasive monitoring and detection of sudden changes in cardiovascular hemodynamics, in which a PPG signal is obtained from a patient, a time-frequency spectrum (TFS) is computed from the PPG signal, instantaneous modulations at a plurality of time points defining a curve of a prominent frequency of oscillation are extracted from the TFS, a peak power spectral density sequence is computed using the instantaneous modulations, and instantaneous peak values for following prominent frequency oscillations are monitored.

Classes IPC  ?

• A61B 5/02 - Détection, mesure ou enregistrement en vue de l'évaluation du système cardio-vasculaire, p. ex. mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin
• A61B 5/0205 - Évaluation simultanée de l'état cardio-vasculaire et de l'état d'autres parties du corps, p. ex. de l'état cardiaque et respiratoire
• A61B 5/024 - Mesure du pouls ou des pulsations cardiaques
• A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
• A61B 5/021 - Mesure de la pression dans le cœur ou dans les vaisseaux sanguins
• A61B 5/08 - Dispositifs de mesure pour examiner les organes respiratoires
• A61B 5/1455 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang en utilisant des capteurs optiques, p. ex. des oxymètres à photométrie spectrale

Abrégé

A method of treating a pulmonary disease such as, for instance idiopathic pulmonary fibrosis (IPF), mixed connective tissue disease and asthma, comprising administering an aerosolized interferon such as interferon γ in a therapeutically effective amount is provided herein. Also, pharmaceutical compositions of one or more aerosolized interferon(s) alone or in combination with other therapeutic agents are provided.

Classes IPC  ?

• A61K 38/00 - Préparations médicinales contenant des peptides
• A61K 38/21 - Interférons
• C07K 14/00 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés

Abrégé

A high flux and low pressure drop microfiltration (MF) membrane and a method for making the MF membrane. The microfiltration membranes are formed by a method that includes: preparing a nanofibrous structure; and modifying the surface of the nanofibrous structure with a surface modifier. The nanofibrous structure includes an electrospun nanofibrous scaffold or a polysaccharide nanofiber infused nanoscaffold or mixtures thereof. The electrospun nanofibrous scaffold can include polyacrylonitrile (PAN) or polyethersulfone (PES))/polyethylene terephthalate (PET) or mixtures thereof. The surface modifier includes polyethylenimine (PEI) and polyvinyl amine (Lupamin) cross-linked by ethylene glycol diglycidyl ether (EGdGE)/glycidyltrimethylammonium chloride (GTMAC1) or poly(l-(l- vinylimidazolium)ethyl-3-vinylimdazolium dibromide (VEVIMIBr).

Classes IPC  ?

• B01D 71/06 - Matériaux organiques

Abrégé

CD155 tumors) expressing CD155, the poliovirus receptor, and is effective for oncolytic treatment and cure of solid tumors, such as neuroblastoma.

Classes IPC  ?

• A61K 39/12 - Antigènes viraux
• C12N 7/00 - Virus, p. ex. bactériophagesCompositions les contenantLeur préparation ou purification
• A61K 35/76 - VirusParticules sous-viralesBactériophages

Abrégé

A method for determining a sentiment associated with an entity includes inputting a plurality of texts associated with the entity, labeling seed words in the plurality of texts as positive or negative, determining a score estimate for the plurality of words based on the labeling, re-enumerating paths of the plurality of words and determining a number of sentiment alternations, determining a final score for the plurality of words using only paths whose number of alternations is within a threshold, converting the final scores to corresponding z-scores for each of the plurality of words, and outputting the sentiment associated with the entity.

Classes IPC  ?

• G06F 17/27 - Analyse automatique, p.ex. analyse grammaticale, correction orthographique

Abrégé

A optical control sensor system includes a driver (102) controlling operation of a light source (103) coupled to an end of an optical fiber (105), an orthogonal signal generator (101), generating a set of different orthogonal signals controlling the driver, a terminal sensor (104) coupled to another end of the optical fiber selecting a predetermined set of input orthogonal signals for converting them into component combinations, constituting output signals, and directing the output signals back to the optical fiber, a device (108) coupled to the light sources and to the first end of the optical fiber for extracting output signals that have passed through a return path in the optical fiber, a detector (109) converting optical output signals into electrical signals, and a selector (110) and a decoder (111) connected to the orthogonal signal generator indicating a current state of the optical control sensor system.

Classes IPC  ?

• G02B 6/00 - Guides de lumièreDétails de structure de dispositions comprenant des guides de lumière et d'autres éléments optiques, p. ex. des moyens de couplage

Abrégé

The invention relates to the development of chimeric OspA molecules for use in against Lyme disease or borreliosis vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with the distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies.

Classes IPC  ?

• A61K 39/02 - Antigènes bactériens
• C07K 14/20 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries provenant de Spirochaetales (O), p. ex. Tréponème, Leptospira

Abrégé

The present invention relates to SHIP inhibitor compounds and methods for using these compounds. In particular, the present invention discloses the following methods: (i) a method of treating graft versus host disease in a subject; (ii) a method of inhibiting a SHIP1 protein in a cell; (iii) a method of selectively inhibiting a SHIP1 protein in a cell; (iv) a method for treating or preventing graft-versus-host disease (GVHD) in a recipient of an organ or tissue transplant; (v) a method of modulating SHIP activity in a cell expressing SHIP1 or SHIP2; (vi) a method of ex vivo or in vitro treatment of transplants; (vii) a method of inhibiting tumor growth and metastasis in a subject; (viii) a method of treating a hematologic malignancy in a subject; (ix) a method of inducing apoptosis of multiple myeloma cells; (x) a method of treating multiple myeloma in a subject; (xi) a method of inhibiting the proliferation of a human breast cancer cell; and (xii) a method of treating breast cancer in a subject.

Classes IPC  ?

• C07C 401/00 - Produits d'irradiation du cholestérol ou de ses dérivésDérivés de vitamine D, séco-9,10 cyclopenta[a]phénanthrène ou leurs analogues obtenus par préparation chimique sans irradiation
• A61K 31/565 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes non substitués en position 17 bêta par un atome de carbone, p. ex. œstrane, œstradiol
• A61K 31/575 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne d'au moins trois atomes de carbone, p. ex. cholane, cholestane, ergostérol, sitostérol
• A61K 31/56 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes
• A61P 35/00 - Agents anticancéreux

Abrégé

A method, system, and computer-readable medium for detecting a disease of a prostate. Exemplary embodiments of the present disclosure can include receiving an image dataset acquired with at least one acquisition mode; segmenting a region of interest including the prostate from the dataset; applying conformal mapping to map the region of interest to a canonical shape; generating a 3D visualization of the prostate using the canonically mapped dataset; and applying computer aided detection (CAD) to the canonically mapped volume to detect a region of disease of the organ.

Classes IPC  ?

• G06K 9/00 - Méthodes ou dispositions pour la lecture ou la reconnaissance de caractères imprimés ou écrits ou pour la reconnaissance de formes, p.ex. d'empreintes digitales

Abrégé

The present invention relates to genetic analysis and evaluation utilizing copy-number variants or polymorphisms. The methods utilize array comparative genomic hybridization and PCR assays to identify the significance of copy number variations in a human or non-human animal subject or subject group.

Classes IPC  ?

• C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
• G06F 19/18 - pour la génomique ou la protéomique fonctionnelle, p.ex. associations génotype-phénotype, déséquilibre de liaison, mutagénèse, génotypage ou annotation génomique, interactions protéines-protéines ou interactions protéines-acides nucléiques
• C12Q 1/6813 - Tests d’hybridation

Abrégé

The performance of a radio frequency identification (RFID) system is improved by a protocol that eliminates collisions between signals generated by a) RFID tags that the RFID reader has already identified as being in its interrogation zone and b) RFID tags that are newly arrived and thus that the reader has not yet identified. This is illustratively accomplished by the use of separate identification and access frames. It is during the identification frame that newly arrived tags become identified by the reader. Although there may be collisions during the identification frame, those collisions are only among newly arrived tags. The already-identified tags communicate with the reader during respective time slots of the access frame, so that they neither collide with each other nor with the newly arrived tags.

Classes IPC  ?

• H04Q 5/22 - Dispositifs de sélection dans lesquels plusieurs postes d’abonnés sont connectés par la même ligne au central avec connexion indirecte, c.-à-d. à travers un centre de commutation subordonné le centre subordonné ne permettant pas une interconnexion d'abonnés reliés à ce centre

Abrégé

The invention relates to the field of polymers and olefin polymerization, and more specifically olefin metathesis polymerization. The invention provides regioregular alternating polymers and methods of synthesizing such polymers.

Classes IPC  ?

• C08F 4/44 - MétauxHydrures métalliquesComposés organiques de métalLeur utilisation comme précurseurs de catalyseurs choisis parmi les métaux légers, le zinc, le cadmium, le mercure, le cuivre, l'argent, l'or, le bore, le gallium, l'indium, le thallium, les terres rares ou les actinides

Abrégé

Synthesis of nanoparticles with particle size control is provided by the method of using two different metal-containing precursors, a capping component, an optional reducing agent, and then contacting the two precursors with the capping component to form a reaction solution, which is heated to produce first and second metals-containing nanoparticles. By controlling the ratio of the concentration of the capping component to the total concentration of the two metal-containing precursors, the nanoparticles can have diameters ranging between about 1 nm to about 15 nm. A decrease in the concentration of the capping component typically increases the size of the nanoparticles. Preferred compositions include Pt and Co- containing alloy nanoparticles. Controlled synthesis of larger, about 6 nm to about 12 nm, sized nanoparticles can be achieved in a solvent-free reaction process.

Classes IPC  ?

• B22F 1/00 - Poudres métalliquesTraitement des poudres métalliques, p. ex. en vue de faciliter leur mise en œuvre ou d'améliorer leurs propriétés
• B22F 9/24 - Fabrication des poudres métalliques ou de leurs suspensionsAppareils ou dispositifs spécialement adaptés à cet effet par un procédé chimique avec réduction de mélanges métalliques à partir de mélanges métalliques liquides, p. ex. de solutions
• C22B 11/00 - Obtention des métaux nobles

Abrégé

Synthesis of nanoparticles with particle size control is provided by the method of using two different metal-containing precursors, a capping component, an optional reducing agent, and then contacting the two precursors with the capping component to form a reaction solution, which is heated to produce first and second metals-containing nanoparticles. By controlling the ratio of the concentration of the capping component to the total concentration of the two metal-containing precursors, the nanoparticles can have diameters ranging between about 1 nm to about 15 nm. A decrease in the concentration of the capping component typically increases the size of the nanoparticles. Preferred compositions include Pt and Co-containing alloy nanoparticles. Controlled synthesis of larger, about 6 nm to about 12 nm, sized nanoparticles can be achieved in a solvent-free reaction process.

Classes IPC  ?

• B22F 9/18 - Fabrication des poudres métalliques ou de leurs suspensionsAppareils ou dispositifs spécialement adaptés à cet effet par un procédé chimique avec réduction de mélanges métalliques

Abrégé

Method and apparatus are provided for automated determination and adjustment of height and tilt of a substrate surface within a lithography system. The method includes: directing a beam of light onto the substrate surface, which reflects off the substrate surface as a reflected beam; optically splitting the reflected beam into a first reflected beam portion and a second reflected beam portion; impinging the first reflected beam portion onto a first detector plane of a first optical detector to generate intensity data, and impinging the second reflected beam portion onto a second detector plane of a second optical detector to generate intensity data, and utilizing the generated data in determining height and tilt of the substrate surface relative to a nominal writing plane of the lithography system. Responsive to the determination, focus or tilt of the system's writing beam, or position of the substrate surface within the system, is adjusted.

Classes IPC  ?

• H01L 21/027 - Fabrication de masques sur des corps semi-conducteurs pour traitement photolithographique ultérieur, non prévue dans le groupe ou
• H01L 21/68 - Appareils spécialement adaptés pour la manipulation des dispositifs à semi-conducteurs ou des dispositifs électriques à l'état solide pendant leur fabrication ou leur traitementAppareils spécialement adaptés pour la manipulation des plaquettes pendant la fabrication ou le traitement des dispositifs à semi-conducteurs ou des dispositifs électriques à l'état solide ou de leurs composants pour le positionnement, l'orientation ou l'alignement

Abrégé

Disclosed is an apparatus and system for monitoring drug regimen compliance, the system utilizing a Radio Frequency Identification (RfID) tag affixed to a pharmaceutical agent and a wearable RFID reader that identifies a patient. The RFID tag identifies the pharmaceutical agent and the RFID reader wirelessly communicates with a central monitoring system upon ingestion of the pharmaceutical agent.

Classes IPC  ?

• G06Q 50/00 - Technologies de l’information et de la communication [TIC] spécialement adaptées à la mise en œuvre des procédés d’affaires d’un secteur particulier d’activité économique, p. ex. aux services d’utilité publique ou au tourisme

Abrégé

Virtually augmented endoscopy includes overlaying optical endoscopy image data with a virtual endoscopy model. Image distortion in the optical endoscopy image data can be substantially reduced. Features in the virtual endoscopy model can be correlated with features in the optical endoscopy image data to improve examination performance. A correlation path through the virtual endoscopy model can be determined that reasonably follows the physical path of an endoscope. A 2D or 3D correlation model can be generated from the image data and correlated to the virtual endoscopy model. Correlation between the scan data domain and the image data domain can use either the correlation path, correlation model or a combination thereof. CAD tools and other features of virtual endoscopy can then be applied to enhance the performance of optical endoscopy.

Classes IPC  ?

• A61B 1/00 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments
• A61B 1/06 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments avec dispositifs d'éclairement
• A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
• A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique

Abrégé

A method for fluorescence detection that provides control of experimental and molecular factors and reliably predicts of concentration from fluorescence intensity measurements utilizing capillary-based flow sensors utilizing a dual detector approach to provide instantaneous normalization of the fluorescent intensity by the Rayleigh scattered intensity measured from the same sensing volume, insensitive to various experimental parameters for prediction of absolute concentrations of fluorescent solutes.

Classes IPC  ?

• G01N 33/483 - Analyse physique de matériau biologique

Abrégé

A device, system, and method for isolating a ventilator from one or more patients in which the delivery conditions of gas delivered to an isolation device from a ventilator may drive the delivery of breathing-gas delivered to one or more patients, the breathing-gas having the same or different delivery conditions. In one embodiment, an isolation device may have a housing and a movable partition. The movable partition may be joined to the housing, The movable partition may have a patient side on a first side of the partition and an actuating side on a second side of the partition. The isolation device may include an inlet pressure regulator on the actuating side and/or an exhaust pressure regulator on the patient side. These regulators may alter the delivery conditions (including, but not limited to, pressure and volume) of breathing-gas delivered to a patient.

Classes IPC  ?

• A61M 16/00 - Dispositifs pour agir sur le système respiratoire des patients par un traitement au gaz, p. ex. ventilateursTubes trachéaux

Abrégé

Disclosed is a method for storing digital information for storage in an adversarial setting in which trusted hardware enforces digital information compliance with data storage mandates. Secure storage overhead is minimized by identifying sparsely accessing the trusted hardware based on data retention cycles. Data retention assurances are provided for information stored by a Write-Once Read-Many (WORM) storage system.

Classes IPC  ?

• G06F 21/00 - Dispositions de sécurité pour protéger les calculateurs, leurs composants, les programmes ou les données contre une activité non autorisée
• G06F 15/16 - Associations de plusieurs calculateurs numériques comportant chacun au moins une unité arithmétique, une unité programme et un registre, p. ex. pour le traitement simultané de plusieurs programmes
• G06F 11/30 - Surveillance du fonctionnement
• G06F 17/00 - Équipement ou méthodes de traitement de données ou de calcul numérique, spécialement adaptés à des fonctions spécifiques

Abrégé

A method of treating tuberculosis comprising administering an aerosolized interferon such as interferon α, interferon β or interferon &ggr; in a therapeutically effective amount is provided herein. Also, pharmaceutical compositions of one or more aerosolized interferon(s) are provided.

Classes IPC  ?

• C12P 21/04 - Peptides ou polypeptides cycliques ou pontés, p. ex. bacitracine

Abrégé

A method for determining a sentiment associated with an entity includes inputting a plurality of texts associated with the entity, labeling seed words in the plurality of texts as positive or negative (201), determining a score estimate for the plurality of words based on the labeling (203), re-enumerating paths of the plurality of words and determining a number of sentiment alternations (204), determining a final score for the plurality of words using only paths whose number of alternations is within a threshold (205), converting the final scores to corresponding z-scores for each of the plurality of words (207), and outputting the sentiment associated with the entity.

Classes IPC  ?

• G06F 17/27 - Analyse automatique, p.ex. analyse grammaticale, correction orthographique

Abrégé

An improved method of treating periodontitis includes the steps of: creating a formulation containing a lanthanide-containing protease inhibitor; and applying the formulation to a periodontal area. The lanthanide may be cerium chloride, samarium chloride, lutetium chloride, cerium chloride heptahydrate, lutetium chloride hexahydrate, samarium chloride hexa- hydrate, gadolinium, gadolinium nitrate, gadolinium chloride, gadolinium chloride hexahydrate and gadolinium nitrate hexahydrate. The invention also provides an improved method of reducing dentinal sensitivity, including the steps of: creating a formulation containing at least one of gadolinium and a gadolinium-containing compound; and applying the formulation to a sensitive dentinal area. The formulation may be a paste, a solution or a powder.

Classes IPC  ?

• A61K 8/00 - Cosmétiques ou préparations similaires pour la toilette

Abrégé

The invention relates to the discovery that collagenase injections are effective in dissolving and lysing the collagenase septa network in the skin that comprises cellulite. As such, the invention relates to methods of treating cellulite in a patient in need of such treatment comprising injecting or otherwise delivering the effective amount of purified collagenase to the collagenase septa network of cellulite in the skin. The invention also relates to the use of collagenase in the manufacture of a medicament to treat cellulite of the skin.

Classes IPC  ?

• A61K 38/48 - Hydrolases (3) agissant sur des liaisons peptidiques (3.4)
• A61K 8/66 - Enzymes

Abrégé

The present invention relates to methods and compositions for stimulating the proliferation of cardiomyocytes for enhancement of cardiac repair. The invention is based on. the discovery that upon contact with stem cells, or conditioned media derived from said stem cells, terminally differentiated cardiomyocytes can be stimulated to enter the cell cycle. Additionally, scaffolds capable of attracting stem cells to the area of implantation have been shown to induce cardiomyocyte proliferation. The present invention further relates to the discovery that the Wnt-5 A ligand, which binds to the frizzled receptor (fz), functions to stimulate cardiomyocyte proliferation. The methods and compositions of the invention may be used in the treatment of cardiac disorders including, but not limited to, myocardial dysfunction or infarction. The invention further relates to screening assays designed to identify compounds that modulate the proliferative activity of cardiomyocytes and the use of such compounds in the treatment of cardiac disorders.

Classes IPC  ?

• A61K 35/48 - Organes de reproduction
• A61K 35/26 - LympheGanglions lymphatiquesThymusRateSplénocytesThymocytes
• A61K 35/28 - Moelle osseuseCellules souches hématopoïétiquesCellules souches mésenchymateuses de toutes origines, p. ex. cellules souches dérivées de tissu adipeux
• A61K 38/18 - Facteurs de croissanceRégulateurs de croissance
• A61K 38/48 - Hydrolases (3) agissant sur des liaisons peptidiques (3.4)
• A61L 27/38 - Cellules animales
• A61P 9/10 - Médicaments pour le traitement des troubles du système cardiovasculaire des maladies ischémiques ou athéroscléreuses, p. ex. médicaments antiangineux, vasodilatateurs coronariens, médicaments pour le traitement de l'infarctus du myocarde, de la rétinopathie, de l'insuffisance cérébro-vasculaire, de l'artériosclérose rénale
• C12N 5/077 - Cellules mésenchymateuses, p. ex. cellules osseuses, cellules de cartilage, cellules stromales médulaires, cellules adipeuses ou cellules musculaires
• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique

Abrégé

An omnibus process of pulping and bleaching lignocellulosic materials in which a charge of a lignocellulosic material is biopulped and/or water extracted prior to pulping and bleaching. The lignocellulosic material may be mechanically pulped and bleached in the presence of an enzyme that breaks lignin-carbohydrate complexes. The aqueous extract in embodiments including a water extract step is separated into acetic acid and hemicellulose sugar aqueous solutions.

Classes IPC  ?

• D21C 3/26 - Procédés à plusieurs stades
• D21C 3/02 - Réduction en pâte des matières contenant de la cellulose avec des bases inorganiques ou des composés à réaction alcaline, p. ex. procédés au sulfate
• D21C 9/10 - Blanchiment
• D21C 9/14 - Blanchiment avec des halogènes ou des composés contenant des halogènes avec ClO2 ou des chlorites
• D21C 9/147 - Blanchiment avec de l'oxygène ou ses modifications allotropiques
• D21C 9/153 - Blanchiment avec de l'oxygène ou ses modifications allotropiques avec de l'ozone

Abrégé

This invention provides a chimeric hyperpolarization-activated, cyclic nucleotide-gated (HCN) polypeptide comprising portions of more than one type of HCN channel. The invention also provides methods of treating a subject afflicted with a cardiac rhythm disorder comprising expression of the chimeric HCN polypeptide in a selected region of the heart so as to induce a pacemaker current in the heart and thereby treat the subject.

Classes IPC  ?

• C12N 15/12 - Gènes codant pour des protéines animales
• C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteursVecteurs Utilisation d'hôtes pour ceux-ciRégulation de l'expression
• C07K 14/705 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire
• C12N 5/10 - Cellules modifiées par l'introduction de matériel génétique étranger, p. ex. cellules transformées par des virus
• A61K 31/713 - Acides nucléiques ou oligonucléotides à structure en double-hélice
• A61K 35/12 - Substances provenant de mammifèresCompositions comprenant des tissus ou des cellules non spécifiésCompositions comprenant des cellules souches non embryonnairesCellules génétiquement modifiées
• A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
• C12P 21/02 - Préparation de peptides ou de protéines comportant une séquence connue de plusieurs amino-acides, p. ex. glutathion

Abrégé

This invention provides a bypass bridge comprising a tract of gap junction-coupled cells having a first end and a second end, both ends capable of being attached to two selected sites in a heart so as to allow the conduction of a pacemaker and/or electrical signal/current across the tract between the two sites, wherein the cells functionally express a sodium channel. The invention also provides related methods of making the bypass bridge, methods of implanting same in a heart, and methods of treating a disorder associated with an impaired conduction in a subject's heart.

Classes IPC  ?

• C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
• C12N 5/077 - Cellules mésenchymateuses, p. ex. cellules osseuses, cellules de cartilage, cellules stromales médulaires, cellules adipeuses ou cellules musculaires
• C12N 5/0775 - Cellules souches mésenchymateusesCellules souches dérivées du tissu adipeux

Abrégé

This invention provides pacemaker systems comprising (1) an electronic pacemaker, and (2) a biological pacemaker, wherein the biological pacemaker comprises a cell that functionally expresses a chimeric hyperpolarization-activated, cyclic nucleotide-gated (HCN) ion channel at a level effective to induce pacemaker current in the cell. The invention also provides related biological pacemakers, atrioventricular bridges, methods of making same, and methods of treating a subject afflicted with a cardiac rhythm disorder.

Classes IPC  ?

• A61N 1/368 - Stimulateurs cardiaques commandés par un paramètre physiologique, p. ex. par le potentiel cardiaque comprenant plus d'une électrode coopérant avec différentes régions du cœur
• A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique

Abrégé

The present invention relates to inhibiting angiogenesis with sulfoxide containing compounds, and polymeric forms thereof, in mammals including animals and humans. Sulfoxide containing compounds, and polymeric forms thereof , can be used alone or in combination with standard therapies to inhibit angiogenesis-mediated disorders. The present invention also relates to the combined use of sulfoxide containing compounds, and polymeric forms thereof , with other anti-angiogenesis agents, with various anti- inflammatory and cytotoxic agents as well as with radio-therapeutic agents in cancer, and with laser, photodynamic therapy for ocular-related disorders such as diabetic retinopathy or age-related macular degeneration.

Classes IPC  ?

• A61K 31/10 - SulfuresSulfoxydesSulfones
• A61K 31/095 - Composés du soufre, du sélénium ou du tellure, p. ex. thiols
• A61K 33/04 - Soufre, sélénium ou tellureLeurs composés
• A61P 35/00 - Agents anticancéreux
• A61P 27/00 - Médicaments pour traiter les troubles des sens

Abrégé

A computer-implemented method for ranking a plurality of academic programs includes receiving a plurality of records corresponding to the plurality of academic programs, respectively, combining elements of the plurality of records to determine respective z-scores according to a predetermined metric, and ranking the plurality of academic programs according to the respective z-scores.

Classes IPC  ?

• G06N 5/00 - Agencements informatiques utilisant des modèles fondés sur la connaissance

Abrégé

A method for direct writing an electrically conductive metallic feature on an insulating substrate comprises creating a gas jet comprising metallic particles (301), ejecting the gas jet comprising metallic particles through a straight bore tube (302), and impacting the gas jet comprising metallic particles onto a substrate to impinge the metallic particles on the substrate to form the electrically conductive metallic feature (303).

Classes IPC  ?

• B05D 1/02 - Procédés pour appliquer des liquides ou d'autres matériaux fluides aux surfaces réalisés par pulvérisation
• B05D 5/12 - Procédés pour appliquer des liquides ou d'autres matériaux fluides aux surfaces pour obtenir des effets, finis ou des structures de surface particuliers pour obtenir un revêtement ayant des propriétés électriques spécifiques

Abrégé

The present teachings are directed toward single metal and alloy nanoparticles and synthesis methods for preparing single metal and alloy nanoparticles.

Classes IPC  ?

• B22F 9/24 - Fabrication des poudres métalliques ou de leurs suspensionsAppareils ou dispositifs spécialement adaptés à cet effet par un procédé chimique avec réduction de mélanges métalliques à partir de mélanges métalliques liquides, p. ex. de solutions

Abrégé

A seamless vertical handoff method allows the network applications and connections on a mobile node to continue without disruption as it moves within a wireless overlay network that comprises multiple possibly overlapping layers of wireless networks (e.g., a WLAN and a WWAN) with different underlying technologies, providing mobile roaming capabilities. The method comprises a WLAN access point signal strength monitor for determining when to switch between WLAN and WWAN, and a network connection migration scheme that can move an active network connection from a wireless link of one technology to another wireless link of a different technology in a way that is transparent to the user, the remote end of the network connection, and the operator of the WWAN carrier.

Classes IPC  ?

• H04Q 7/20 -

Abrégé

A method for fabricating an electronic device comprises providing a substrate (501), direct writing a functional material by a thermal spray on the substrate (502) and removing a portion of the function material to form the electronic or sensory device (503).

Classes IPC  ?

• B23K 26/38 - Enlèvement de matière par perçage ou découpage