The culture insert container has a lower culture container having a bottom portion equipped with a porous membrane and a sidewall, and having an upper insertion fixture having a cylindrical sidewall that is inserted into said lower culture container. The cylindrical sidewall has a land arranged so as to protrude from a top end of the sidewall of the lower culture container at a location such as will cause a top surface of said porous membrane and a bottom end portion of the cylindrical sidewall which is inserted within the lower culture container to be maintained in a noncontacting state. A land is arranged at an outer surface of the cylindrical sidewall so as to cause a constant distance to be maintained between an inner surface of the sidewall of the lower culture container and the outer surface of the cylindrical sidewall.
C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
2.
Atom Beam Generation Device, Physics Package, Physics Package for Optical Lattice Clock, Physics Package for Atomic Clock, Physics Package for Atomic Interferometer, Physics Package for Quantum Information Processing Device, and Physics Package System
An atom beam generation device includes an atomic oven including a reservoir in which a sample is contained, a deceleration unit, and coil units. The deceleration unit includes a bore through which an atomic beam and a slowing laser beam pass, and decelerates an atomic beam emitted from the atomic oven by means of slowing laser beam and a magnetic field. The coil units supply Joule heat to the atomic oven, and generate a magnetic field in the deceleration unit.
A learning method includes: causing an observer to perceive information to be compared by the observer from among a plurality of pieces of perceivable information; acquiring evaluation for the information made by the observer; and rating the plurality of pieces of information based on the evaluation made by the observer for the plurality of pieces of information acquired by a plurality of repetitions of the causing the observer to perceive the information and the acquiring the evaluation.
An object of the present invention is to provide a method capable of detecting activity of an enzyme that strictly recognizes a substrate, such as acetylcholinesterase (AChE). There is provided a method for detecting activity of an enzyme in a biological sample using a microdevice, the method including a step of bringing the biological sample into contact with a substrate analog or a natural substrate, and a compound represented by General Formula (I) below or a salt thereof, wherein the substrate analog or the natural substrate generates a compound A having a thiol group (R—SH), a selenol group (R—SeH), or a poly sulfur atom (R—(S)n-H) (R is a hydrogen atom or an alkyl group, and n is 1 to 5) by a reaction with the enzyme, and fluorescence is observed or measured, the fluorescence being emitted or enhanced from a fluorescent product generated by the reaction of the compound represented by General Formula (I) or the salt thereof with the thiol group, the selenol group, or the poly sulfur atom.
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
C07F 7/08 - Compounds having one or more C—Si linkages
C12Q 1/34 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase
C12Q 1/46 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase involving esterase involving cholinesterase
5.
LIGHT EMITTING ELEMENT AND METHOD FOR MANUFACTURING SAME
For the purpose of improving the luminous efficiency of a light emitting element by increasing conduction characteristics, a light emitting element 100 according to an embodiment of the present disclosure includes an AlGaN-based crystal or an InAlGaN-based crystal, and is provided with a light emitting layer 134, at least one electron blocking layer 138, a first Mg-doped layer 140, and a dam layer 150, which are sequentially stacked in this order in the direction of the flow of electrons. The dam layer 150 has a higher Al composition ratio than the first Mg-doped layer. Another embodiment of the present disclosure provides a method for manufacturing a light emitting element that is provided with an Mg-doped layer of any one of a GaN-based crystal, InGaN-based crystal, AlGaN-based crystal, and InAlGaN-based crystal, the method including an activation step for causing an electron catalytic reaction in a first Mg-doped layer so as to activate Mg into an ionized acceptor.
The present invention enhances light extraction efficiency (LEE) in a 230 nm band UVC-LED. This AlGaN-based deep ultraviolet LED having a light emission wavelength λ has a photonic crystal periodic structure in a thickness direction, wherein the distance between an upper part of a quantum well layer and a bottom part of the photonic crystal periodic structure substantially satisfies a resonance condition λ/n of free end reflection. Here, n is the weighted average refractive index of a layer structure existing between the upper part of the quantum well layer and the bottom part of the photonic crystal periodic structure.
H01L 33/10 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by the semiconductor bodies with a light reflecting structure, e.g. semiconductor Bragg reflector
H01L 33/32 - Materials of the light emitting region containing only elements of group III and group V of the periodic system containing nitrogen
The present invention addresses the problem of elucidating the function of human Mhr1 and providing a method for improving mitochondrial function. Provided is a method for promoting mitochondrial DNA homoplasmy formation or for improving mitochondrial function, the method including introducing a protein having 80% or higher sequence identity with the amino acid sequence represented by SEQ ID NO: 1 or DNA or mRNA encoding a protein having 80% or higher sequence identity with the amino acid sequence represented by SEQ ID NO: 1 into a cell.
A superconducting coil device includes a superconducting coil and adhesive layer. The superconducting coil includes a superconducting wire wound into a coil shape. An electrical conductivity is imparted to the adhesive layer. The adhesive layer constitutes at least a part of a current bypass for the superconducting coil. The adhesive layer includes a binder. The adhesive layer includes a resistance-decrease suppression structure that imparts the electrical conductivity to the adhesive layer while suppressing a decrease in contact resistance with the superconducting wire.
An objective of the present invention is to provide at least one among: an electrode containing a manganese oxide which suppresses the elution of manganese during water electrolysis without reducing hydrogen productivity; and a method for manufacturing the electrode. The electrode includes a conductive substrate, and an oxygen generating electrode catalyst containing iridium-manganese oxide. The content of iridium per geometric area of the conductive substrate is less than 10 μg/cm2.
C25B 11/093 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of at least one catalytic element and at least one catalytic compoundElectrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of two or more catalytic elements or catalytic compounds at least one noble metal or noble metal oxide and at least one non-noble metal oxide
C25B 1/04 - Hydrogen or oxygen by electrolysis of water
C25B 9/00 - Cells or assemblies of cellsConstructional parts of cellsAssemblies of constructional parts, e.g. electrode-diaphragm assembliesProcess-related cell features
C25B 9/23 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof with diaphragms comprising ion-exchange membranes in or on which electrode material is embedded
Provided is a device for estimating the atomic structure of a biomolecule, the device comprising: a generation unit that generates an image generated on the basis of a target biomolecule; an acquisition unit that acquires a plurality of first candidate structure images on the basis of two-dimensional projection images from a plurality of atomic structures prepared; a global search unit that, on the basis of the similarity between the generated image and the candidate structure images, selects, as a basic candidate structure, a structure having a high degree of structural similarity and/or molecular orientation similarity to the target biomolecule from among the plurality of atomic structure candidate structures; and a local search unit that acquires a plurality of second candidate structure images on the basis of two-dimensional projection images of a plurality of modified atomic structures obtained by modifying the basic candidate structure, and selects, on the basis of the similarity between the second candidate structure images and the generated image, a structure having a high degree of structural similarity and/or molecular orientation similarity to the target biomolecule from among the modified atomic structures.
G16C 10/00 - Computational theoretical chemistry, i.e. ICT specially adapted for theoretical aspects of quantum chemistry, molecular mechanics, molecular dynamics or the like
G16C 20/40 - Searching chemical structures or physicochemical data
This inspecting device is a device for inspecting an inner circumferential surface of an object under inspection that has a cylindrical shape. The device comprises: an inspecting unit for emitting terahertz waves toward the inner circumferential surface and detecting reflected waves of the terahertz waves; and a distance measuring unit for measuring the distance between the inspecting unit and the inner circumferential surface. The inspection target and the distance measuring unit are caused to rotate in the circumferential direction of the object under inspection. Further, the relative axial position of the inspecting unit with respect to the object under inspection is adjusted. Further, the position of the inspecting unit in a plane intersecting the axial direction of the object under inspection can be adjusted. Control of the position adjustment mechanism is performed on the basis of the measurement result from the distance measuring unit such that the center of rotation of a rotation unit is positioned on the central axis of the object under inspection.
G01B 15/04 - Measuring arrangements characterised by the use of electromagnetic waves or particle radiation, e.g. by the use of microwaves, X-rays, gamma rays or electrons for measuring contours or curvatures
12.
FILTER CIRCUIT, QUANTUM DEVICE, QUANTUM COMPUTER, FILTER CIRCUIT MANUFACTURING METHOD, FILTER CIRCUIT ASSEMBLY METHOD, READOUT FREQUENCY FILTERING METHOD, AND QUANTUM BIT DISPERSIVE READOUT METHOD
A filter circuit 1 comprises: a readout resonator 11 that is coupled to data quantum bits; and a filter resonator 12 that is configured and is coupled to an observation line. The readout resonator 11 and the filter resonator 12 are electrically and magnetically coupled by using capacitive coupling and inductive coupling in parallel.
Provided is an electrode exhibiting high oxygen generating electrode catalytic activity as compared with conventional electrodes using manganese-based oxide as an oxygen generating electrode catalyst.
C25B 11/093 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of at least one catalytic element and at least one catalytic compoundElectrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of two or more catalytic elements or catalytic compounds at least one noble metal or noble metal oxide and at least one non-noble metal oxide
C25B 1/04 - Hydrogen or oxygen by electrolysis of water
C25B 9/00 - Cells or assemblies of cellsConstructional parts of cellsAssemblies of constructional parts, e.g. electrode-diaphragm assembliesProcess-related cell features
C25B 11/042 - Electrodes formed of a single material
C25B 11/052 - Electrodes comprising one or more electrocatalytic coatings on a substrate
C25B 11/081 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of a single catalytic element or catalytic compound the element being a noble metal
A tissue transplantation resin tip and the like that allow easy transplantation of a tissue sucked inside are provided. A tissue transplantation resin tip 10 according to the present invention includes a needle tube 1 that can be inserted into an eyeball. The needle tube includes a main body portion 11 that extends linearly, and a front end portion 12 that is bent with respect to the main body portion and extends linearly, and that discharges a tissue T from a front end 121. A length L1 of the needle tube is 25 mm or more and 50 mm or less, a cross-sectional external shape of the front end portion has an oval shape having a major axis D1 of 0.8 mm or more and 1.5 mm or less, and a minor axis D2 of 0.5 mm or more and 1.0 mm or less, the front end of the front end portion is a bevel surface that extends in a direction substantially perpendicular to the main body portion, and that has a bevel angle 1 of 50 or more and 85 or less, the hardness of the front end portion is 0.15 N or more and 0.30 N or less, and the hardness of the center of the needle tube is 0.80 N or more and 1.50 N or less.
(1) The purpose of the present invention is to provide an antitumor agent in which an effect of an immune checkpoint inhibitor is enhanced. (2) The purpose of the present invention is also to provide a drug that could exhibit an effect even under conditions in which no antigen is present. (1) Provided is an antitumor agent obtained by combining an immune checkpoint inhibitor with an NKT cell ligand-containing liposome composition. (2) Also provided is a liposome composition containing an NKT cell ligand and an antigen.
A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
A61K 31/7032 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyl-diacylglycerides, lactobionic acid, gangliosides
In order to achieve a charged particle beam sensor capable of measuring beam position with high linearity, provided is a charged particle beam sensor comprising a plurality of electrodes 1-8 that cover a right cylinder side surface. The plurality of electrodes are insulated from each other by a plurality of separation curves which each draw, with respect to a direction along the axis of the right cylinder side surface, a curve from the minimum value to the maximum value of a sine wave relating to a rotation angle in any rotation direction around the axis of the right cylinder side surface. The charged particle beam is disposed so as to pass through the inside of the right cylinder side surface. In a measurement data processing method, a signal wave second-order integral value is calculated.
G01T 1/29 - Measurement performed on radiation beams, e.g. position or section of the beamMeasurement of spatial distribution of radiation
17.
METHOD FOR ACQUIRING VALUE OF AUTONOMIC NERVOUS SYSTEM INDEX FOR EVALUATING MENTAL STATE OF SUBJECT, AND METHOD, SYSTEM, AND PROGRAM FOR EVALUATING MENTAL STATE OF SUBJECT
The present invention provides a method for acquiring the value of an autonomic nervous system index for evaluating the mental state of a subject. The method comprises acquiring the value of the autonomic nervous system index of the subject at a first time point and a second time point. The autonomic nervous system index or a calculated value thereof serves as an index of the mental state of the subject. The method is characterized in that the sleep state of the subject at the first time differs from at the second time point. The present invention also provides a method, for example, for evaluating the mental state of a subject on the basis of an acquired value of an autonomic nervous system index or a calculated value thereof.
The purpose of the present invention is to provide a novel HVEM-binding protein. The present invention provides a human HVEM-binding protein comprising at least one immunoglobulin single variable region, wherein: the immunoglobulin single variable region includes complementarity determining regions 1-3 which have the amino acid sequence of SEQ ID NO: 1, the amino acid sequence of SEQ ID NO: 2, and the amino acid sequence of SEQ ID NO: 3, respectively; and the immunoglobulin single variable region is a humanized VHH. The protein according to the present invention may further comprise a human immunoglobulin Fc region or a human serum albumin-binding protein, and the immunoglobulin Fc region may be an Fc region of human IgG4.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
A film deposition method including installing a substrate on a turntable of a spin coating device such that a first main surface faces the turntable, and adding a first liquid having viscosity dropwise onto a second main surface of the substrate; holding the substrate in the same state until the first liquid added dropwise reaches the first main surface side from the second main surface side through a through-hole; otating the substrate together with the turntable; and heating the first liquid together with the substrate.
A method of producing radionuclides includes installation, irradiation, transport, and trapping steps. In the installation step, a target material containing a target nuclide is placed inside a target chamber. In the irradiation step, at least a portion of the target material is irradiated with a quantum beam. In the transport stage, a carrier gas is supplied to the inside of the target chamber and an ambient gas around the target material is sent to the outside of the target chamber through an exhaust pipe. In the trapping step, a trap device connected to the exhaust pipe is configured to trap the radionuclides produced from the target nuclide from the ambient gas. In some cases, a target holding device for quantum beam irradiation comprising a target material container and a rotational drive mechanism is also provided, as well as a quantum beam irradiation system. An example target material container is rotatable.
G21G 1/04 - Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation, or particle bombardment, e.g. producing radioactive isotopes outside of nuclear reactors or particle accelerators
G21G 1/00 - Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation, or particle bombardment, e.g. producing radioactive isotopes
G21K 5/08 - Holders for targets or for objects to be irradiated
The present invention provides a plant root system morphology control means which is effective and easy to use. The present invention provides a plant root system morphology control agent comprising 2-aminopimelic acid or a salt or ester thereof.
A01N 37/44 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio-analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio-analogue of a carboxylic group, e.g. amino-carboxylic acids
A01G 7/06 - Treatment of growing trees or plants, e.g. for preventing decay of wood, for tingeing flowers or wood, for prolonging the life of plants
A01H 3/04 - Processes for modifying phenotypes by treatment with chemicals
A data integration apparatus according to one embodiment includes a controller including a platform for automatically performing a type conversion of an object, an acquisition unit, an interpreter, and an integrator. The acquisition unit acquires each data as a graph in which an object of the platform is a constituent element, or as a collection of information in a language format in which an object is associated with a word. The interpreter performs an interpretation process for converting the constituent element of the graph into a type on a hyponymy-side. The integrator performs an integration process for holding information generated by the interpretation process and information acquired by the acquisition unit, and reflecting the information on the graph. The data integration apparatus operates when the controller repeatedly and automatically performs the interpretation process and the integration process.
G06F 30/12 - Geometric CAD characterised by design entry means specially adapted for CAD, e.g. graphical user interfaces [GUI] specially adapted for CAD
G06F 30/13 - Architectural design, e.g. computer-aided architectural design [CAAD] related to design of buildings, bridges, landscapes, production plants or roads
Provided is an LED having a quantum well structure and comprising: a quantum well layer having a composition AlaGa1-aN (aluminum gallium nitride) (0 < a < 1); and a high-level layer that has a composition AlbGa1-bN (a < b ≤ 1), is adjacent to the quantum well layer, and has an energy level higher than that of the quantum well layer. ΔX, which is the difference between a and b, and the width D [nm] of the quantum well layer satisfy [relational expression 1] D = k/ΔX (where, in the relational expression 1, D > 3, 0 < ΔX < 0.15, and 0.45 ≤ k ≤ 1.25 (unit of the coefficient k is [nm])).
H01L 33/06 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by the semiconductor bodies with a quantum effect structure or superlattice, e.g. tunnel junction within the light emitting region, e.g. quantum confinement structure or tunnel barrier
H01L 33/14 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by the semiconductor bodies with a carrier transport control structure, e.g. highly-doped semiconductor layer or current-blocking structure
H01L 33/32 - Materials of the light emitting region containing only elements of group III and group V of the periodic system containing nitrogen
H01S 5/343 - Structure or shape of the active regionMaterials used for the active region comprising quantum well or superlattice structures, e.g. single quantum well [SQW] lasers, multiple quantum well [MQW] lasers or graded index separate confinement heterostructure [GRINSCH] lasers in AIIIBV compounds, e.g. AlGaAs-laser
The present invention pertains to: a guide RNA having, on the 5' side of a spacer sequence, a repeat sequence that is cleaved through processing for forming a cascade complex, and not having a repeat sequence or having a sequence that is not cleaved through processing for forming a cascade complex, on the 3' side of the spacer sequence; and a type-I CRISPR-Cas system using the guide RNA.
A sample preparation system (100) includes a position identification section (34) that associates a plurality of cells constituting a cell group with the respective plurality of cells constituting the cell group in which at least a part of junctions between adjacent ones of the plurality of cells is disconnected, in a dispersion process of (i) disconnecting at least the part of the junctions between the adjacent ones of the plurality of cells in the cell group in which the plurality of cells are joined to each other and (ii) dispersing the cell group. This allows the realization of a technique of collecting a cell and specifying the position of the collected cell in an original cell group.
An observation device includes a neutron emission device, a detection device, and a data processing device. The neutron emission device emits neutrons to an inspection object. The detection device detects exit neutrons from the inspection object at one set of detection positions in a peripheral direction around the inspection object, outside the inspection object, and measures the number of the detected exit neutrons for each of the detection positions. The data processing device generates reconstructed cross-sectional data by performing reconstruction processing based on the number of the detected exit neutrons at each of the one set of detection positions. The reconstructed cross-sectional data represent a two-dimensional distribution of a neutron reaction rate in an imaginary cross-section of the inspection object.
G01N 23/05 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by transmitting the radiation through the material and forming images of the material using neutrons
NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (Japan)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
Inventor
Yamamoto Michihisa
Takada Shintaro
Bauerle Christopher
Abstract
Provided is a quantum computer, including: an input unit for inputting an electron wave packet; a propagation unit that propagates the electron wave packet in a predetermined direction and has a loop-like loop path; and a qubit generation unit that generates a time-bin qubit by using the electron wave packet.
Provided is a method for efficiently preparing a library. The method for preparing a library includes the steps of (a) synthesizing single-stranded cDNA from 10 pg or more of template RNA; (b) synthesizing double-stranded cDNA from the single-stranded cDNA; and (c) preparing a library using the double-stranded cDNA that is unpurified.
NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM (Japan)
RIKEN (Japan)
Inventor
Furukawa Taiki
Oyama Shintaro
Yokota Hideo
Abstract
This information processing device is provided with a state information acquisition unit and an analysis processing unit. The state information acquisition unit continuously acquires objective state information of a patient suffering from a disease, and subjective state information based on the patient's subjectivity. On the basis of the objective state information and the subjective state information, and using a predetermined information processing technique, the analysis processing unit continuously executes predetermined analysis processing including setting of a policy recommended to be executed by the patient in order to improve the symptom of the disease, and outputs the result of the analysis processing in a manner that can be perceived by the patient.
G16H 20/30 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
31.
ESTIMATION DEVICE, ESTIMATION SYSTEM, ESTIMATION METHOD, AND PROGRAM
Provided is an estimation device comprising a control unit that executes an estimation process for estimating dynamic information, which is information relating to the behavior of platelets, on the basis of video data from a video showing the flow of platelets in the blood. In the estimation process, the control unit executes a correlation acquisition process for, on the basis of the video data, acquiring information indicating a correlation among frames, from among a plurality of frames included in the video, satisfying the condition that a difference in time indicated by a time code is smaller than a preset time difference, and estimates the dynamic information on the basis of the result of the correlation acquisition process.
A composition for decomposition of trypsin or TMPRSS2 containing, as an active ingredient, bacteria that have 00502 protein, or a protein having 30% or higher sequence identity with an amino acid sequence of the 00502 protein and having a trypsin-binding ability; or bacteria that have 00509 protein, or a protein having 30% or higher sequence identity with an amino acid sequence of the 00509 protein and having a trypsin-binding ability.
The preventive or therapeutic agent for benign adult familial myoclonus epilepsy (BAFME) of the present invention contains an antisense oligonucleotide containing at least one of the base sequences of SEQ ID NOS: 1 to 4. Among the antisense oligonucleotides, oligonucleotide consisting of at least one of the base sequences of SEQ ID NOS: 1 to 4 may contain at least one RNase H inactive type nucleotide analog. The RNase H inactive type nucleotide analog may be β-D-oxy-L-LNA, β-D-ENA, R type cEt, 2′-OMe-nucleotide analog, and/or MOE-nucleotide analog.
Provided are: a composition for ammonia storage and an ammonia bonding composition, with which ammonia can be stored relatively easily under mild conditions and can be stored with high safety; and an ammonia storage device and an ammonia storage method, which use same. The composition for ammonia storage contains a compound for ammonia storage which is represented by any of specific formulae (I-a) to (I-c). In addition, the ammonia bonding composition contains said composition for ammonia storage and is obtained by bonding the compound to an ammonia molecule and a water molecule. In addition, the ammonia storage device, the ammonia storage method and an ammonia molecule removal method use the foregoing.
The present invention relates to a method for conducting phylogenetic analysis of cells. The method of the present invention includes steps of: (1) comparing, for a plurality of single cells derived from the same individual, the RNA sequence data of the transcriptome of each single cell with the corresponding genome sequence data, and then screening for a site where the RNA sequence differs from the genome sequence; (2) screening the sites identified by screening in step (1) for a site where three or more single nucleotide polymorphisms are detected, as a site of somatic mutation; and (3) generating a cell lineage tree based on the nucleotide sequence information of the site of somatic mutation obtained in step (2).
Provided is a technique for examining an autoimmune disease. This method for examining an autoimmune disease involves (1) a step for examining the presence or absence of endogenous human herpesvirus 6B in genomic DNA of a biological sample sampled from a subject.
Provided is a novel drug for tumor therapy which targets an S1P signaling pathway. A tumor therapeutic agent according to one embodiment of the present invention which comprises a complex that includes an acrolein reaction site having a chemical structure represented by formula (1), and a detachment site, wherein the detachment site is bonded to the acrolein reaction site via a linker that can be cleaved by a reaction between the acrolein reaction site and acrolein, and the detachment site includes a chemical structure of a compound which exhibits an activity for inhibiting sphingosine-1-phosphate signal transduction in a cell.
The present invention aims to provide a method for suppressing differentiation of ganglion cell, amacrine cell, horizontal cell and/or bipolar cell in a neural retina tissue containing photoreceptor precursor and/or photoreceptor, and the like. A method for suppressing differentiation of a ganglion cell, an amacrine cell, a horizontal cell and/or a bipolar cell in a neural retinal tissue containing a photoreceptor precursor and/or a photoreceptor, including a step of culturing a retinal tissue comprising a neural retinal progenitor cell and in any stage between a differentiation stage immediately after emergence of a ganglion cell and a differentiation stage where emergence rate of a cone photoreceptor precursor reaches maximum in a medium containing a thyroid gland hormone signal transduction pathway agonist.
A quality monitoring apparatus (10) is provided with a quality measurement device (30) that irradiates a food (1) with an electromagnetic wave, and measures an index value indicating the quality state of the food (1) on the basis of the response of the food (1) to the irradiation. The quality measurement device (30) is provided with a Raman scattered light measurement device (30A) that irradiates a food with laser light as an electromagnetic wave, and measures, as an index value, a value related to the intensity of Raman scattered light generated from the food 1 with respect to the laser light. Alternatively, the quality measurement device (30) is provided with a terahertz wave measurement device (30B) that irradiates the food (1) with a terahertz wave as an electromagnetic wave, and measures, as an index value, a value related to the absorption rate of the terahertz wave in the food (1).
A23L 5/30 - Physical treatment, e.g. electrical or magnetic means, wave energy or irradiation
F24C 7/04 - Stoves or ranges heated by electric energy with heat radiated directly from the heating element
G01N 21/3586 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using far infrared lightInvestigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using Terahertz radiation by Terahertz time domain spectroscopy [THz-TDS]
40.
METHOD FOR MATURING CARDIOMYOCYTES, AND METHOD FOR PRODUCING MATURED CARDIOMYOCYTES
A method for producing matured cardiomyocytes, the method comprising: a preparation step for preparing a sample containing immature cardiomyocytes; and a pressure loading step for continuously or intermittently applying hydrostatic pressure to the sample.
In one embodiment of the present disclosure, in order to increase production efficiency of astatine (At)-211, provided is a method for producing At by α-particle beam irradiation, and the method includes: an installation step S32 for receiving and arranging, in a housing part of a target material container (3), a target material (4) containing bismuth (Bi)-209; a rotation drive irradiation step S40 for irradiating at least a portion of the target material (4) with an α-particle beam (2) while rotating the target material container (3) around a rotation axis; a transportation step S46, after said step S40, for supplying a carrier gas and sending, through an exhaust pipe, an atmospheric gas around the target material; and a collection step S46 for collecting, from the atmospheric gas, astatine-211 generated from Bi by the irradiating with the α-particle beam. In a preferred embodiment of the present disclosure, the rotation drive irradiation step is performed with Bi of the target material in a solid state. Further, in a preferred embodiment of the present disclosure, the target material container is heated to a temperature higher than the melting point of Bi and lower than the boiling point of Bi in either or both of the transportation step or the collection step.
G21K 5/08 - Holders for targets or for objects to be irradiated
G21G 1/10 - Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation, or particle bombardment, e.g. producing radioactive isotopes outside of nuclear reactors or particle accelerators by bombardment with electrically-charged particles
G21K 1/00 - Arrangements for handling particles or ionising radiation, e.g. focusing or moderating
42.
CELL LABELING MOLECULE AND METHOD FOR ANALYZING CELL
A cell labeling molecule comprising a particle 101 having an identifiable property, an identification sequence 102 that is identifiable and corresponds to the property of the particle 101, a cleavable linker 103 that binds the particle 101 and the identification sequence 102, and a binding molecule 104 for binding to a cell, the binding molecule being bound to the identification sequence 102.
Provided is an ATAC-seq method including: step (a) for contacting a transposome with a chromatin and tagmenting an open chromatin region to obtain a population of tagmented DNA fragments, wherein the transposome is a complex in which a DNA fragment having a transposase binding sequence and a desired nucleotide sequence is bound to the transposase bound, and each of the tagmented DNA fragments has the desired nucleotide sequence at the end; step (b) for amplifying and sequencing the population of the tagmented DNA fragments to obtain a population of reads; and step (c) for analyzing the population of the reads. In this ATAC-seq method, the desired nucleotide sequence includes a nucleotide sequence for amplification and a recognition sequence in this order in the 5'- to 3'-direction, and the amplification of the population of the tagmented DNA fragments is performed using a primer specific to a target region on the genomic DNA and a primer specific to the nucleotide sequence for amplification.
The present invention relates to a method for labeling a cell with a barcode. The method for labeling a cell with a barcode of the invention includes (1) for a cell group containing a plurality of single cells, directly or indirectly bringing a cell surface protein of the cell into contact with a modified barcode; or (2) directly or indirectly bringing a cell surface protein of a single cell into contact with a modified barcode.
A liquid jet generation device 100 according to the present embodiment generates and recovers a jet of a liquid in a vacuum, and comprises: a vacuum chamber 70; a discharge device 10 that discharges a liquid into the vacuum chamber; a catcher assembly 20 that has a skimmer 21 for recovering the liquid discharged from the discharge device; and a first positioning device 30 that positions the catcher assembly with respect to the liquid. It is thereby possible to form a liquid jet in a vacuum and recover the liquid from the vacuum.
B05B 1/14 - Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means with multiple outlet openingsNozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means with strainers in or outside the outlet opening
B05C 11/00 - Component parts, details or accessories not specifically provided for in groups
B05C 11/10 - Storage, supply or control of liquid or other fluent materialRecovery of excess liquid or other fluent material
G01N 23/083 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by transmitting the radiation through the material and measuring the absorption the radiation being X-rays
G21K 1/06 - Arrangements for handling particles or ionising radiation, e.g. focusing or moderating using diffraction, refraction, or reflection, e.g. monochromators
G21K 5/02 - Irradiation devices having no beam-forming means
G21K 5/10 - Irradiation devices with provision for relative movement of beam source and object to be irradiated
Provided is a system comprising a management server, a robot, and a sensor that measures an environment including a space of an action range of the robot. The management server is provided with: a reception unit that receives a mission; and a command unit that generates a command on the basis of the mission and transmits the command to the robot. The command includes a first command representing a state after execution of the mission. The robot is provided with: a state specification unit that specifies an environmental state of the robot including a state of an article handled by the robot on the basis of measurement data of the sensor; and an instruction unit that receives the command and drives the robot so that the state of the robot approaches a state represented by the command on the basis of the difference between the specified state and the state represented by the command.
A feature extraction device extract features of a target from a plurality of images related to the target. The image processor calculates, using an image model, a likelihood of the inputted image belonging to a first image class, and a feature parameter of the inputted image. A feature processor that inputs an image included in the inputted image group into the image processor to calculate the likelihood and the feature parameter, selects, based on the calculated likelihood, a predetermined number of representative images from the inputted image group, and outputs, as feature information of the image group, the feature parameter calculated for the selected predetermined number of representative images. A classification processor is an additional element, inputs a target image group related to a target to the feature processor, and predicts, from the outputted feature information and using a classification model, whether the target belongs to a first target class. Here, an image belonging to the first image class corresponds to the target belonging to the first target class.
G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
G06V 10/77 - Processing image or video features in feature spacesArrangements for image or video recognition or understanding using pattern recognition or machine learning using data integration or data reduction, e.g. principal component analysis [PCA] or independent component analysis [ICA] or self-organising maps [SOM]Blind source separation
G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
An object of the present invention is to a new method of producing a kidney organoid. The method for producing a kidney organoid is characterized by comprising culturing an early kidney organoid with a medium containing an RXR agonist and a PPAR agonist, wherein the kidney organoid includes matured proximal tubule cells.
The present invention addresses the problem of providing a feature for forming large ribosomal subunits in vitro by a simpler method. The present invention relates to a large ribosomal subunit production method, the method comprising mixing a plurality of proteins or derivatives thereof for forming large ribosomal subunits with a plurality of RNAs or variants thereof for forming large ribosomal subunits in the presence of GTPase Der to form large ribosomal subunits. The present invention also relates to a ribosome production method, a peptide production method, and a kit.
To improve the emission efficiency of ultraviolet light emitting diodes in the Far-UVC wavelength range, the ultraviolet light emitting diode in one embodiment has a semiconductor layer that includes aluminum, gallium and nitrogen. It may also include Indium. In various embodiments, it may include an AlGaN-based crystal or an InAlGaN-based crystal. The relative atomic ratios of aluminum, gallium, nitrogen and indium may vary at different positions in the layer. The diode comprises a light emitting layer, a spacer layer and an electron blocking layer in this order along the electron flow direction. The Al composition ratio in the spacer layer varies along the position in the thickness direction of the layers. The ultraviolet light emitting diode of the embodiment of the present disclosure can be provided with the emitting layer comprising at least one barrier layer and at least two quantum well layers sandwiching the barrier layer.
H01L 33/14 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by the semiconductor bodies with a carrier transport control structure, e.g. highly-doped semiconductor layer or current-blocking structure
H01L 33/06 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by the semiconductor bodies with a quantum effect structure or superlattice, e.g. tunnel junction within the light emitting region, e.g. quantum confinement structure or tunnel barrier
H01L 33/32 - Materials of the light emitting region containing only elements of group III and group V of the periodic system containing nitrogen
51.
DATA COLLECTION METHOD, DATA-COLLECTING MOVEMENT DEVICE, TRAINED MODEL, METHOD FOR PRODUCING TRAINED MODEL, AUTONOMOUS MOVEMENT DEVICE, AND METHOD FOR PRODUCING LEARNING DATA
Provided are a data collection method, a data-collecting movement device, a trained model, a method for producing a trained model, an autonomous movement device, and a method for producing learning data that make it possible to improve accuracy of determination of a movement route by inference of machine learning. This data collection method is used for constructing a trained model used by an autonomous movement device in order to determine a host movement route in accordance with circumstances in the surroundings. A person moves a data-collecting movement device having a heteronomous movement mechanism under the circumstances in the surroundings (S22), and collects data representing the movement route of the data-collecting movement device under the circumstances in the surroundings from one or more sensors (S23). The heteronomous movement mechanism has a structure common to the movement mechanism of the autonomous movement device so as to enable movement simulating the movement of the autonomous movement device.
The present invention relates to a fusion protein. A fusion protein according to the present invention contains a cyan fluorescent protein, a ligand-binding region of a peroxisome proliferator-activated receptor, and a yellow fluorescent protein, wherein the ligand-binding region of the peroxisome proliferator-activated receptor is included between the cyan fluorescent protein and the yellow fluorescent protein, and the coactivator peptide of the peroxisome proliferator-activated receptor is not included.
The present invention addresses the problem of providing a method for detecting a target molecule more simply and safely than a conventional detection method by using a peptide aptamer specifically binding to a virus including influenza and other target molecules. The problem is solved by providing a detecting agent of a target molecule, comprising the following (1) and (2): (1) an alcohol-resistant peptide aptamer for the target molecule, containing an amino acid linked with a fluorescent molecule, and (2) an alcohol.
The present invention provides techniques for enabling estimation of the value of a perceived index. The present invention provides a system for estimating the value of a perceived index. The system comprises: a reception means for receiving the value of at least one objective index of a subject; an estimation means for estimating the value of a perceived index of the subject on the basis of the value of the at least one objective index; and an output means for outputting the estimated value or an output based on the estimated value. Typically, the estimation means estimates the value of the perceived index of the subject using a trained model.
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
A direct-current bus control system is provided for controlling power variation in a DC bus connecting an input power source and a load, including: a main stabilizer including a first charge/discharge element and a first power converter; and a plurality of sub-stabilizers each including a second charge/discharge element, a charge element, or a discharge element, and a second power converter. The plurality of sub-stabilizers include a first sub-stabilizer and a second sub-stabilizer including the charge element. When the voltage of the DC bus is higher than a first charge threshold, the second power converter of the first sub-stabilizer supplies a current equal to a current target value obtained by the second power converter of the first sub-stabilizer from the DC bus to the charge element of the first sub-stabilizer.
A first light-receiving element of an embodiment of the disclosure includes: a semiconductor substrate including a photoelectric conversion region; a first first electrically-conductive region provided at a first surface interface of the semiconductor substrate and coupled to a first electrode; a second first electrically-conductive region provided around the first first electrically-conductive region and coupled to a second electrode, at the first surface interface; a third first electrically-conductive region in an electrically floating state provided around the second first electrically-conductive region, at the first surface interface; a first second electrically-conductive region having a different electrically-conductive type between the first first electrically-conductive region and the second first electrically-conductive region, at the first surface interface; and a fourth first electrically-conductive region provided at least between the first first electrically conductive region and the first second electrically-conductive region and having an impurity concentration lower than the first first electrically-conductive region, near the first surface interface.
A non-transitory computer-readable recording medium stores a program that causes a computer to execute a process performed in an information processing system. The process includes acquiring data with which at least one of a year, a month, a date, an hour, a minute, or a second is associated; extracting at least one analysis target from the data acquired at the acquiring; creating a graph of a cumulative value of a value relating to the analysis target with respect to a period; calculating a first area formed by the graph and an x-axis; and identifying a pattern of a graph shape based on the first area.
The present invention addresses the problem of providing: a method for preparing a DNA library, in which method the RNA is amplified from an RNA material in an early stage of the procedure, thereby minimizing the loss of the RNA material in the procedure; and a method for performing the sequence determination and/or quantification of RNA molecules using this DNA library. The present invention provides a method for preparing a DNA library from a sample containing RNA. The method for preparing a DNA library comprises: (1) a step for attaching a first DNA linker to a 3' end of at least one RNA molecule in an RNA-containing sample to obtain an RNA molecule having the first DNA linker, wherein the first DNA linker includes at least a promoter antisense sequence; (2) a step for hybridizing a first oligonucleotide to the RNA molecule having the first DNA linker to obtain an RNA molecule having a double-stranded DNA promoter region, wherein the first oligonucleotide includes a promotor sense sequence; (3) a step for obtaining a complementary strand of an RNA molecule (complementary RNA) having the first DNA linker, by in vitro transcription with an RNA polymerase which starts transcription by recognizing a promoter sequence, using the RNA molecule having the double-stranded DNA promoter region as a template; and (4) a step for connecting a second DNA linker to the 3' end of the complementary RNA and performing reverse transcription using the complementary RNA having the second DNA linker as a template, to obtain a single-stranded DNA.
The present invention addresses the problem of providing a means for removing mutant mtDNA from a cell after homoplasmization of the cell. The present invention relates to: a homoplasmization promoter that comprises a reactive oxygen species or a chemical species which generates a reactive oxygen species in a cell, and a mitophagy promoter, or that comprises a substance that has the effect of generating a reactive oxygen species in a cell and the effect of promoting mitophagy; and a homoplasmization promotion method which uses the homoplasmization promoter. The present invention also relates to: a method for using the homoplasmization promotion method to prepare a homoplasmic cell; and a homoplasmic cell produced by said method.
A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
A61K 31/522 - Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
A61P 43/00 - Drugs for specific purposes, not provided for in groups
In order to improve the resolution of an image of a luminescent material excited by X-rays, an embodiment of the present disclosure provides a microscope 100 comprising an X-ray radiation unit and an observation optical system. The X-ray radiation unit 10 generates a patterned X-ray sheet beam 1 for illuminating an observation object 7. This patterned X-ray sheet beam has an intensity pattern 2 in which the intensity repeatedly varies with respect to a position in a certain direction included in the expansion in a partial region 32 of an expanding sheet region 3. The observation optical system 50 is arranged to receive radiation of an observation wavelength from an observation region 4, the observation region including at least a portion of the partial region. An embodiment of the present disclosure also provides a method for capturing an image of a luminescent material.
G02B 21/36 - Microscopes arranged for photographic purposes or projection purposes
G21K 1/00 - Arrangements for handling particles or ionising radiation, e.g. focusing or moderating
G21K 1/06 - Arrangements for handling particles or ionising radiation, e.g. focusing or moderating using diffraction, refraction, or reflection, e.g. monochromators
G21K 5/02 - Irradiation devices having no beam-forming means
A propulsion strengthening member attached to a surface of an object existing in outer space, the propulsion strengthening member includes: a transparent member that transmits an emitted laser; and an opaque member that is provided between the transparent member and the object and absorbs the laser such that at least a part thereof is evaporated by energy of the laser.
B32B 27/08 - Layered products essentially comprising synthetic resin as the main or only constituent of a layer next to another layer of a specific substance of synthetic resin of a different kind
F41H 13/00 - Means of attack or defence not otherwise provided for
62.
TRAINING DEVICE, EVALUATION DEVICE, TRAINING METHOD, AND PROGRAM
A training device according to one aspect of the present disclosure trains a model that evaluates text, in a document format, with respect to a prescribed issue. The training device includes: a first user interface provision unit that provides a first user interface capable of at least designating data for training the model; and a training unit that trains the model on the basis of the training data and index values representing the degree of contribution to the quality of the model.
INTER-UNIVERSITY RESEARCH INSTITUTE CORPORATION, RESEARCH ORGANIZATION OF INFORMATION AND SYSTEMS (Japan)
KAKE EDUCATIONAL INSTITUTION (Japan)
Inventor
Taniuchi Ichiro
Kanemaki Masato
Hayashi Ken-Ichiro
Abstract
The present invention provides novel technology which makes it possible to control the function of a protein in the living body of mouse with high temporal resolution. Provided is a genetically modified mouse, said genetically modified mouse comprising: a pair of Cre recombinase recognition sequences; a transcription termination polyA sequence that is located between the pair of Cre recombinase recognition sequences; a transport inhibitor response 1 (TIR1) family gene sequence that is located downstream of the pair of Cre recombinase recognition sequences and that codes for a TIR1 family protein; and a promoter sequence that is located upstream of the pair of Cre recombinase recognition sequences, and that can drive expression of the TIR1 family gene after recombination of the pair of Cre recombinase recognition sequences.
The present invention relates to a gel structure containing a gel composition that contains at least one anisotropic nanostructure, at least one liquid, and at least one polymer having a crosslinked structure. In a static state, the gel structure has at least one surface. The major axes of each of the at least one anisotropic nanostructure are oriented almost in parallel to each other and in non-parallel and non-perpendicular to the aforesaid at least one surface.
C08L 101/14 - Compositions of unspecified macromolecular compounds characterised by physical features, e.g. anisotropy, viscosity or electrical conductivity the macromolecular compounds being water soluble or water swellable, e.g. aqueous gels
C08L 33/26 - Homopolymers or copolymers of acrylamide or methacrylamide
C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
C12N 1/00 - Microorganisms, e.g. protozoaCompositions thereofProcesses of propagating, maintaining or preserving microorganisms or compositions thereofProcesses of preparing or isolating a composition containing a microorganismCulture media therefor
65.
METHOD FOR EVALUATING RECEPTOR-TYPE TYROSINE KINASE ACTIVITY
One embodiment provides a novel method that allows evaluation of receptor tyronsine kinase (RTK) activity. The present invention relates to a method for evaluating RTK activity, the method comprising: a step (A1) of determining the diffusion kinetics A1 of a labeled RTK by bringing a substance of interest into contact with cells that express said RTK on the cell membrane; a step (B1) of determining the diffusion kinetics B1 of a labeled RTK by bringing a substance of interest and a ligand that activates said RTK into contact with cells that express said RTK on the cell membrane; a step (C1) of calculating the ratio between the diffusion kinetics A1 of the RTK obtained by said step (A1) and the diffusion kinetics B1 of the RTK obtained by said step (B1); and a step (D1) of evaluating the effect of the substance of interest on RTK activity by comparing the ratio of diffusion kinetics obtained in step (C1) with a threshold value. In step (D1), the ratio of diffusion kinetics obtained in step (C1) being above the threshold value can indicate that the substance of interest has an effect on the molecular function of the RTK.
C12Q 1/48 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving transferase
C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving viable microorganisms
The present invention provides a novel polyester resin that exhibits biodegradability in seawater, and a method for producing the polyester resin. The ocean-biodegradable polyester resin contains a polymer having: a structural unit derived from succinic acid; a structural unit derived from a dicarboxylic acid having 7 or more carbon atoms; and a structural unit derived from at least one aliphatic diol selected from the group consisting of ethylene glycol, 1,2-propanediol and 1,3-propanediol.
The present invention provides a polyester amide resin having excellent gas barrier properties and biodegradability, and a method for producing the polyester amide resin. The polyester amide resin contains a polymer having: a structural unit (A) derived from succinic acid; a structural unit (B) derived from a dicarboxylic acid having 5 or more carbon atoms; a structural unit (C) derived from an aliphatic diol, and a structural unit (D) derived from an amino acid.
A non-destructive inspection device includes a neutron generation portion, a neutron shield portion, a gamma ray detector, and a gamma ray shield portion. The neutron generation portion emits neutrons spontaneously, or emits neutrons by DD nuclear fusion reaction or DT nuclear fusion reaction. The neutron shield portion is covers the neutron generation portion from at least an area around the neutron generation portion and thereby shields the neutrons at the area, and allows the neutrons to be emitted to a front side of the neutron generation portion. The gamma ray detector detects gamma rays generated in an inspection object on a front side of the neutron generation portion. The gamma rays are generated by the neutrons incident on the inspection object. The neutron shield portion, the gamma ray shield portion, and the gamma ray detector are arranged in this order in alignment with each other in a lateral direction.
G01N 23/222 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by measuring secondary emission from the material by activation analysis using neutron activation analysis [NAA]
A laser amplification medium includes: a clad part; a first core part and a second core part; a virtual first, second, and third layers. The first core part and the second core part extend parallel to an axis direction. The first layer includes the first core part, the second core part, and a part of the clad part. The second layer and the third layer include a part of the clad part. Each side face of the first core part and the second core part includes a first planar portion and a second planar portion. The first planar portion is included in a first surface of the first layer, the first surface being a virtual bonding interface with the second layer. The second planar portion is included in a second surface of the first layer, the second surface being a virtual bonding interface with the third layer.
In order to realize a far-ultraviolet irradiation device having increased output, an embodiment of the present disclosure provides a lens-attached irradiation device 100. In the lens-attached irradiation device, a module 1 is disposed in each of a plurality of element sites 10 forming a planar array, the module 1 having a radiating direction in a direction 90 normal to the planar array. The module 1 comprises: an ultraviolet light emitting diode (UVLED) element which includes an AlGaN-based crystal or InAlGaN-based crystal and emits a far-ultraviolet ray with a wavelength from 220 nm to 240 nm; and a lens 6 which is disposed in a far-ultraviolet radiating path corresponding to each UVLED element, and which is transmissive to the wavelength. An embodiment of the present disclosure further provides a reflector-attached irradiation device comprising: UVLED elements disposed in a plurality of element sites forming a planar array; and a reflector having a reflecting surface for reflecting a far-ultraviolet ray inclined from the radiating direction of the UVLED element in the radiating direction.
B01J 19/12 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor employing electromagnetic waves
H01L 33/00 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof
H01L 33/32 - Materials of the light emitting region containing only elements of group III and group V of the periodic system containing nitrogen
To provide a synthesis scheme capable of easily synthesizing various kinds of fluorescent probes. A method for preparing a compound represented by Formula (III) below, the method including steps (1) to (5).
To provide a synthesis scheme capable of easily synthesizing various kinds of fluorescent probes. A method for preparing a compound represented by Formula (III) below, the method including steps (1) to (5).
C12Q 1/37 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase involving peptidase or proteinase
[Problem] The purpose of the present disclosure is to provide a protein selectively recognizing cancer caused by a mutation of K-Ras gene (referred to herein as "K-Ras gene mutation cancer"). [Solution] Provided are: a method for producing a protein selectively recognizing K-ras gene mutation cancer, the method being characterized by including first to third steps for linking first to third specific sugar chains respectively to lysine residues on a protein molecule; and a protein produced by this method. Also provided is a pharmaceutical composition for cancer treatment, the pharmaceutical composition containing the protein.
A61K 47/61 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
73.
IRIDIUM-MANGANESE OXIDE COMPOSITE MATERIAL, IRIDIUM-MANGANESE OXIDE COMPOSITE ELECTRODE MATERIAL AND METHODS FOR PRODUCING THE SAME
Provided are an iridium-manganese oxide composite material and an iridium-manganese oxide composite electrode material that are inexpensive and have high catalytic activity for use in an anode catalyst for oxygen evolution associated with water electrolysis. Also provided are methods for producing the same. An iridium-manganese oxide composite material includes a manganese oxide and iridium distributed on at least a surface of the manganese oxide, the iridium having a metal valence of 3.1 or greater and 3.8 or less. An iridium-manganese oxide composite electrode material includes a conductive substrate formed of a fiber, with the iridium-manganese oxide composite material being coated on at least a portion of the conductive substrate.
C25B 11/093 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of at least one catalytic element and at least one catalytic compoundElectrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of two or more catalytic elements or catalytic compounds at least one noble metal or noble metal oxide and at least one non-noble metal oxide
C25B 1/04 - Hydrogen or oxygen by electrolysis of water
C25B 9/23 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof with diaphragms comprising ion-exchange membranes in or on which electrode material is embedded
C25D 9/04 - Electrolytic coating other than with metals with inorganic materials
74.
NON-DESTRUCTIVE INSPECTION DEVICE AND NON-DESTRUCTIVE INSPECTION SYSTEM
This non-destructive inspection system 1 has a non-destructive inspection device 2 and a management device 3. The non-destructive inspection device 2 is provided with: a neutron emission unit 10 capable of emitting a neutron beam; a gamma ray detection unit 20 capable of detecting gamma rays; a device casing 30 covering the neutron emission unit 10 and the gamma ray detection unit 20, an opening 30a being formed in the device casing 30; an outer shutter 31 that opens/closes the opening 30a; dose monitors 51, 52, 53 provided to the device casing 30, the dose monitors 51, 52, 53 detecting the radiation dose; a device communication unit 56 capable of transmitting device information including the detected radiation dose to the management device 3, and capable of receiving inspection permission information from the management device 3; and a device control unit 40 that, when the inspection permission information is acquired, opens the outer shutter 31 and enables emission of a neutron beam from the neutron emission unit 10.
G01N 23/222 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by measuring secondary emission from the material by activation analysis using neutron activation analysis [NAA]
Provided are a disease risk evaluation method, a disease risk evaluation system and a health information processing device, whereby it becomes possible to detect the latent onset tendency in a healthy stage in advance and to quantify the prospective disease risk of a disease of interest. Each of the disease risk evaluation method, the disease risk evaluation system and the health information processing device according to the present invention includes a plurality of steps, i.e., a step for classifying into a group in which the susceptibility to developing a specific disease is high and a group in which the susceptibility to developing the specific disease is low regardless of the degree of progression of the disease from a healthy stage until the onset of the disease, and a step for further classifying the degrees of the development of the disease in a group in which the incidence risk is determined as high. Each of the disease risk evaluation method, the disease risk evaluation system and the health information processing device is characterized by being achieved by changing the type of data to be used in a data-driven analysis in each of the steps.
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
76.
STRUCTURE FOR OPTICAL OBSERVATION, METHOD FOR FORMING SAME, METHOD FOR OBSERVING SAMPLE, AND MOUNTING LIQUID FOR MICROSCOPIC OBSERVATION
A structure for optical observation according to the present disclosure is obtained by sequentially arranging a liquid immersion objective lens, an immersion liquid, a light-transmitting sample placement member, and a sample that has been processed with a mounting liquid in the stated order on the optical axis of the liquid immersion objective lens. In the visible light region, the refractive index difference and the Abbe number difference between the immersion liquid and the mounting liquid are both 5% or less.
SHIZUOKA PREFECTURAL UNIVERSITY CORPORATION (Japan)
RIKEN (Japan)
JAPAN AS REPRESENTED BY DIRECTOR-GENERAL OF NATIONAL INSTITUTE OF INFECTIOUS DISEASES (Japan)
Inventor
Watanabe Kenji
Osada Hiroyuki
Watanabe Shogo
Kawatani Makoto
Nakajima Shogo
Hishiki Takayuki
Watashi Koichi
Abstract
The present disclosure addresses the problem of providing a novel compound that has the basic structure of furanocoumarin and is useful as a medicine. The present embodiment is a compound represented by formula (I) or a salt thereof (in formula (I), R11-61-6 alkyl group; R21-201-63-203-201-61-61-201-20-alkyl group; and Ar1and Ar25-203-203-20 heteroaryl group).
A61K 31/4545 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
C07D 493/02 - Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
78.
INIBHITION OF REVERSE TRANSCRIPTION DERIVED FROM RIBOSOMAL RNA
Provided are a composition and a method for inhibiting the reverse transcription of a ribosomal RNA. This composition for inhibiting the reverse transcription of a ribosomal RNA is characterized by containing a polymer having at least one functional group selected from the group consisting of sulfuric acid groups, sulfone groups, and basic groups thereof, and by being used in an amount such that the polymer concentration in a reverse transcription reaction solution is 10 pg/μL or more.
C12Q 1/6848 - Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
An object of the present invention is to provide a method for producing a retinal cell or retinal tissue with a reduced proportion of non-target cells in differentiating pluripotent stem cells. The method of the present invention for producing a retinal cell or retinal tissue comprises: (A) suspension-culturing a pluripotent stem cell to form a cell aggregate of pluripotent stem cells; and (B) suspension-culturing the cell aggregate obtained in the step (A) in the presence of a BMP signaling pathway agonist and a CHK1 signaling pathway inhibitor to obtain a cell aggregate containing a retinal cell.
Provided is a component analyzing device 1 including: a projection unit 11 which projects light on an object; a measurement unit 12 which detects reflected light, scattered light, or emitted light from the object and measures a content of a related substance, which is contained together with a target substance in the object, from a detection result; and an estimation unit 13 which estimates a content of the target substance from a measurement result of the content of the related substance, based on a quantitative relationship between the target substance and the related substance derived from a reaction equation system based on a biosynthetic metabolic pathway of the object.
A non-transitory computer-readable recording medium stores therein a path selecting program that causes a computer to execute a process including extracting a plurality of representative points from a presence probability distribution of states of a target, identifying a first plurality of state transition paths between the plurality of representative points, and selecting a second plurality of state transition paths from the first plurality of state transition paths, based on a probability density of each path included in the first plurality of state transition paths.
A non-transitory computer-readable recording medium stores therein an information output program that causes a computer to execute a process including acquiring a first point and a second point in a presence probability distribution of a state of an object, specifying a plurality of points serving as candidates for a transition destination from the first point, selecting a third point from the points based on a distance from the first point to each of the points and probability during transition, and outputting a transition path from the first point to the second point including the third point as state transition information on the object.
The death of some pluripotent stem cells in suspension culture of pluripotent stem cells is avoided. When performing the suspension culture of the pluripotent stem cells, a liquid medium that does not substantially contain a PKCβ inhibitor is used for a single-cell state and a liquid medium containing a PKCβ inhibitor and a WNT inhibitor is used after a cell mass is formed.
A thrust generating device according to the present invention is a thrust generating device for irradiating a target with a laser beam to generate thrust for the target, the thrust generating device including: a laser beam generating device that generates a first laser beam having a first wavelength and a second laser beam having a second wavelength different from the first wavelength; and an irradiation device that simultaneously irradiates the target with the first laser beam and the second laser beam. The second wavelength may be a wavelength having a high absorptivity in the target than the first wavelength, and the intensity of the second laser beam may be lower than that of the first laser beam. Further, the second laser beam may be generated by converting the wavelength of the first laser beam.
G02F 1/39 - Non-linear optics for parametric generation or amplification of light, infrared, or ultraviolet waves
85.
ARTIFICIAL ADJUVANT VECTOR CELL CAPABLE OF INDUCING IMMUNE RESPONSE TO CORONAVIRUS, PHARMACEUTICAL COMPOSITION CONTAINING SAID CELL, AND USE APPLICATIONS OF SAID CELL AND SAID PHARMACEUTICAL COMPOSITION
The present disclosure provides an artificial adjuvant vector cell inducing an immune response to a spike protein of a coronavirus, a pharmaceutical composition containing the cell, and use of the cell and the composition. According to the present disclosure, the cell can be an artificial adjuvant vector cell (aAVC) expressing a spike protein of a coronavirus.
C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses
C07K 14/74 - Major histocompatibility complex [MHC]
86.
STRING-LIKE AGGREGATES OF RETINAL PIGMENT EPITHELIAL CELLS, DEVICE AND PRODUCTION METHOD FOR PRODUCING SAME, AND THERAPEUTIC AGENT COMPRISING SAID STRING-LIKE AGGREGATES
The present invention provides a transplant material of a retinal pigment epithelial cell that can be prepared in a short time at a low cost, and that can be easily controlled at the site of transplantation even though the transplantation method is non-invasive, and a method for producing such transplant material.
A spider mite repellent comprises at least one oil selected from the group consisting of olive oils, olive pomace oils, and partially hydrogenated high-oleic rapeseed oils as an active ingredient.
A01N 25/30 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
The present invention relates to a therapeutic drug for a disease accompanied by a disorder in retinal cells or a retinal tissue, the drug including a retinal tissue, the retinal tissue being of an allogeneic origin and having a three-dimensional structure, wherein an intended patient to be given the therapeutic drug is a patient affected by a disease accompanied by a disorder of retinal cells or a retinal tissue, to be given systemically, for 1 month or more after the administration of the therapeutic drug, no immunosuppressive agent aimed at preventing graft rejection.
A tomographic image processing device generates a pseudo tomographic image from a moving image in which a cross section is captured via a light-receiving surface of a puncture member that punctures a living body. Herein, an acquirer acquires the moving image in which the cross section is captured via the light-receiving surface of the puncture member that punctures the living body. A corrector performs image correction of each frame of the moving image, based on a shape of the light-receiving surface. A tracker tracks a candidate for a picture of tissue of the living body that satisfies a desired tracking condition. An estimator estimates a representative vector, based on a movement vector of the candidate. An extractor extracts a candidate in which the movement vector is similar to the representative vector. A calculator calculates, based on a drawing position in a frame in which a picture of the extracted candidate is drawn in the moving image and an order of the frame, an arrangement position in which the picture of the candidate needs to be arranged. A generator generates a pseudo tomographic image of the living body by drawing the picture of the extracted candidate in the calculated arrangement position.
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
A novel fluorescent protein and uses thereof are provided. A polypeptide of the present invention has a fluorescence property, the polypeptide being indicated in any one of (1) to (3) below: (1) a polypeptide having an amino acid sequence set forth in SEQ ID NO: 1; (2) a polypeptide having an amino acid sequence set forth in SEQ ID NO: 1, the amino acid sequence having replaced, deleted, inserted, and/or added therein not less than 1 and not more than 32 amino acids; and (3) a polypeptide having not less than 85% sequence identity with respect to an amino acid sequence set forth in SEQ ID NO: 1.
C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
C12N 15/70 - Vectors or expression systems specially adapted for E. coli
G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
91.
PLANT HAVING ENHANCED RESISTANCE AGAINST COLORADO POTATO BEETLE AND METHOD FOR PRODUCING SAME, AND METHOD FOR EVALUATING RESISTANCE AGAINST COLORADO POTATO BEETLE IN PLANT
NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY (Japan)
NATIONAL AGRICUL TURE AND FOOD RESEARCH ORGANIZATION (Japan)
RIKEN (Japan)
Inventor
Umemoto, Naoyuki
Mizutani, Masaharu
Akiyama, Ryota
Asano, Kenji
Hamada, Haruyasu
Nagira, Yozo
Endo, Akira
Saito, Kazuki
Abstract
The spirosolane skeleton 23-position hydroxylase gene and the spirosolane skeleton 23-position acetyltransferase gene derived from S. chacoense, S. tuberosum, and S. lycopersicum are found to be involved with the biosynthesis of leptine, which achieves resistance against Colorado potato beetle.
To increase the ceiling of operating temperature of quantum cascade lasers in THz range, the quantum cascade laser element of the present disclosure has a semiconductor superlattice structure with an active region that emits electromagnetic waves of a certain frequency in the THz range under the external voltage applied through a pair of electrodes for operation. The quantum well structure of the unit structure that comprises this semiconductor superlattice structure has quantum levels of electrons in an isolated three-level structure. In one example, each unit structure has a two-quantum well structure having a first well layer and a second well layer, which are separated from each other by a barrier layer, the first well layer including a first sublayer, a second sublayer with a composition different from that of the first sublayer, and a third sublayer, which has the same composition as the first sublayer.
H01S 5/34 - Structure or shape of the active regionMaterials used for the active region comprising quantum well or superlattice structures, e.g. single quantum well [SQW] lasers, multiple quantum well [MQW] lasers or graded index separate confinement heterostructure [GRINSCH] lasers
H01S 5/343 - Structure or shape of the active regionMaterials used for the active region comprising quantum well or superlattice structures, e.g. single quantum well [SQW] lasers, multiple quantum well [MQW] lasers or graded index separate confinement heterostructure [GRINSCH] lasers in AIIIBV compounds, e.g. AlGaAs-laser
93.
NOVEL BIOACTIVE SUBSTANCE EXHIBITING ANTIMALARIAL ACTIVITY, AND USE FOR SAME
The present invention relates to a compound represented by the following formula (I):
The present invention relates to a compound represented by the following formula (I):
The present invention relates to a compound represented by the following formula (I):
and an antimalarial drug comprising the compound.
C07D 207/273 - 2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
A61K 31/4015 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
A light-receiving element according to an embodiment of the present disclosure includes: a semiconductor substrate including a photoelectric conversion region; a first first electrically-conductive region provided at an interface of a first surface of the semiconductor substrate and coupled to a first electrode; a second first electrically-conductive region provided at the interface of the first surface and around the first first electrically-conductive region and coupled to a second electrode; a third first electrically-conductive region provided at the interface of the first surface and around the second first electrically-conductive region and being in an electrically floating state; and an electrically-conductive film provided above the first surface at least between the first first electrically-conductive region and the second first electrically-conductive region.
A nondestructive inspection system 1 is provided with: a neutron radiation unit 10 capable of radiating a first neutron dose of neutrons; a neutron detection unit 20 capable of detecting a second neutron dose of neutrons scattered inside an inspection object A upon radiation of neutrons from the neutron radiation unit 10; a gamma ray detection unit 30 capable of detecting a gamma ray dose released from the inspection object A upon radiation of neutrons from the neutron radiation unit 10; and an analysis unit 50 that calculates the contained amount of a predetermined substance on the basis of the gamma ray dose and corrects the contained amount of the predetermined substance on the basis of the first neutron dose and the second neutron dose.
G01N 23/222 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by measuring secondary emission from the material by activation analysis using neutron activation analysis [NAA]
G01N 23/204 - Measuring back scattering using neutrons
G01N 23/2206 - Combination of two or more measurements, at least one measurement being that of secondary emission, e.g. combination of secondary electron [SE] measurement and back-scattered electron [BSE] measurement
96.
Method and System Thereof for Detecting Objects in the Field of View of an Optical Detection Device
A computer-implemented method for detecting objects in the field of view of an optical detection device is provided that includes (i) acquiring, through the optical detection device, a plurality of subsequent frames of a portion of an observed space in a time interval, wherein each frame is acquired in a corresponding time instant of the time interval; (ii) selecting a subset of frames from the plurality of frames; (iii) for each set of values of shifting parameters of a plurality of sets of values of shifting parameters that are indicative corresponding predetermined motions of an object with respect to the optical detection device, determining a corresponding first stacked frame on the basis of the subset of frames and as a function of the set of values of the shifting parameters; (iv) for each first stacked frame, determining whether the first stacked frame belongs to a first or a second class, wherein the first and the second class are respectively indicative of the presence or absence of an image of an object in the first stacked frame; and (v) selecting, among the sets of values of shifting parameters, each set of values of shifting parameters that is associated to corresponding first stacked frame classified as belonging to the first class. The method further includes, for each selected set of values of shifting parameters: (i) determining a corresponding second stacked frame on the basis of the set of frames and as a function of the selected set of values of shifting parameters; (ii) for each second stacked frame, determining whether the second stacked frame belongs to a third or a fourth class wherein the third and the fourth class are respectively indicative of the presence or absence of an image of an object in the second stacked frame; (iii) determining if the first stacked frame classified as belonging to the first class and in the second stacked frame classified as belonging to the third class meet a requirement; and (iv) if the requirement is met, indicate the presence of an object.
G06T 7/246 - Analysis of motion using feature-based methods, e.g. the tracking of corners or segments
97.
Slow Atomic Beam Generator, Physical Package, Physical Package For Optical Lattice Clock, Physical Package For Atomic Clock, Physical Package For Atomic Interferometer, Physical Package For Quantum Information Processing Device, And Physical Package System
A high-temperature tank includes an optical window which transmits a laser and is provided at one end, and a right-angle conical mirror which is provided at the other end, has an opening at the apex, and which reflects laser light incident from the optical window towards the one end in an area other than opening. A magnetic field generator generates a magnetic field in the region of intersection of the laser reflected by the right-angle conical mirror. A magnetic field gradient attenuation module locally attenuates the gradient of the magnetic field generated by the magnetic field generator.
H03L 7/26 - Automatic control of frequency or phaseSynchronisation using energy levels of molecules, atoms, or subatomic particles as a frequency reference
G04F 5/14 - Apparatus for producing preselected time intervals for use as timing standards using atomic clocks
98.
METHOD AND DEVICE FOR INDUCING HYPOMETABOLIC STATE IN SUBJECT WITH DISEASE
The present invention provides a method for inducing a hibernation-like state and an apparatus therefor. According to the present invention, provided is a method for decreasing a theoretical setpoint temperature of body temperature and a feedback gain of heat generation in a subject or a method for inducing a hibernation-like state in a subject, the method being a chemical and/or physical method including providing an excitatory stimulus to a pyroglutamylated RFamide peptide (QRFP)-producing neuron. According to the present invention, an apparatus used to practice this method is also provided.
A light-receiving element according to an embodiment of the present disclosure includes: a semiconductor substrate (11) including a photoelectric conversion region; a first electrically-conductive region (13A) provided at an interface of one surface of the semiconductor substrate (11) and coupled to a first electrode (16); a second first electrically-conductive region (13B) provided at the interface of the one surface and around the first first electrically-conductive region (13A) and coupled to a second electrode (17); and a third first electrically-conductive region (13C) provided at the interface of the one surface and around the second first electrically-conductive region (13B) and being in an electrically floating state.
A nondestructive inspecting device 1 is provided with: a neutron beam emitting unit 10 capable of emitting a neutron beam in a prescribed emission direction D1; a gamma ray detecting unit 20 capable of detecting a gamma ray incident from a prescribed detection direction D2 intersecting the emission direction D1; a device housing 30 which covers the neutron beam emitting unit 10 and the gamma ray detecting unit 20, and in which an opening portion 30a is formed in the emission direction D1 and the detection direction D2; an outer shutter 31 for opening and closing the opening portion 30a of the device housing 30; an external dose monitor 41 for detecting a radiation dose inside the device housing 30; an internal dose monitor 42 for detecting a radiation dose outside the device housing 30; and a control unit 40 for prohibiting opening of the outer shutter 31 if the radiation dose detected by at least either of the dose monitors 41, 42 exceeds a predetermined threshold.
G01N 23/00 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or
G01N 23/22 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by measuring secondary emission from the material
patents
