The purposes of the present invention are to provide a method of easily introducing a gene to mitochondria from the outside of a cell, and to provide a method of introducing a relatively large nucleic acid to mitochondria. A carrier peptide for introducing a nucleic acid to mitochondria is provided, which comprises a mitochondrial-targeting sequence and a polycationic sequence, wherein said mitochondrial-targeting sequence consists of an N-terminal region comprising a transmembrane domain in a mitoNEET protein.
This method for producing vascular endothelial cells derived from pluripotent stem cells comprises: a preparation step for preparing vascular endothelial progenitor cells derived from pluripotent stem cells; and a stress application step for applying a fluid shear stress to the vascular endothelial progenitor cells.
The present invention addresses the problem of providing a simple and efficient method for inducing differentiation of pluripotent stem cells into neural crest cells. Provided is a method for producing neural crest cells, said method comprising a step for culturing stem cells for at least 6 days under conditions in which the expression or activity of a novel protein kinase C (nPKC) and/or an atypical protein kinase C (aPKC) is suppressed or inhibited.
C12N 1/00 - Micro-organismes, p. ex. protozoairesCompositions les contenantProcédés de culture ou de conservation de micro-organismes, ou de compositions les contenantProcédés de préparation ou d'isolement d'une composition contenant un micro-organismeLeurs milieux de culture
C12N 5/10 - Cellules modifiées par l'introduction de matériel génétique étranger, p. ex. cellules transformées par des virus
The present disclosure provides a method for designing a peptide sequence for increasing a binding capability with respect to a target substance. The present disclosure combines protein complex structure prediction, the accuracy of which has recently rapidly increased, with binding capability prediction from a structure, predicts a structure of a complex of a target substance and a peptide, and predicts and compares binding capabilities of a plurality of modified peptides with respect to the target substance, thereby acquiring a peptide sequence having a high binding capability with respect to the target substance. The present disclosure also provides an adeno-associated virus (AAV) vector which passes through a blood-brain barrier (BBB).
Provided is a three-dimensional shaped carbon structure having a nanocarbon structure, the nanocarbon structure including at least one of a petal-shaped structure with flaky carbons fixed into a petal shape, each of the flaky carbons having a graphene skeleton and a thickness of less than 20 nm; and a projected-and-recessed structure formed by an assembly of seed-shaped structures, each of the seed-shaped structures having a size of 1 to 100 nm. The carbon structure has a good formability and an excellent durability in high radiation fields, and is further useful as a reflector of a cold neutron or an extremely cold neutron that can achieve high strengths of the cold neutron and the extremely cold neutron through coherent scattering.
Provided are a production method of retinal pigment epithelial (RPE) cells that improves differentiation induction efficiency of pluripotent stem cells into RPE cells, and can provide highly pure RPE cells by a simple and easy operation in a short period, a culture method of RPE cells that can stably grow and culture a cell, a toxicity/efficacy evaluation method using RPE cells useful for transplantation therapy, and a therapeutic drug for a retinal disease. The invention relates to a production method of RPE cells, comprising adhesion culture of human pluripotent stem cells using a culture substrate coated with a laminin-E8 fragment, a culture method of RPE cells, comprising adhesion culture of RPE cells using a culture substrate coated with a laminin-E8 fragment, a toxicity or efficacy evaluation method using RPE cells obtained by producing or culturing by the method, and a therapeutic drug for a retinal disease, containing the RPE cells.
In order to obtain a high-output quantum cascade laser (QCL) element, the QCL according to an embodiment of the present disclosure comprises: a first electrode 101 that is a uniform film extending beyond a certain range; a semiconductor superlattice structure 110 that is disposed on or above the first electrode and has an active region 112 comprising a plurality of repeatedly stacked unit structures; and a second electrode 102 that is disposed on or above the semiconductor superlattice structure. A plasma conductive layer 105 is disposed at least either between the first electrode and the semiconductor superlattice structure or between the semiconductor superlattice structure and the second electrode, so that a radiation field magnetic field between the first electrode and the second electrode exhibits asymmetry with respect to a coordinate in the thickness direction. In the second electrode, a photonic crystal including an array of openings passing therethrough in the thickness direction is formed so as to extend in the above range. The second electrode is a radiation surface.
H01S 5/185 - Lasers à émission de surface [lasers SE], p. ex. comportant à la fois des cavités horizontales et verticales comportant uniquement des cavités horizontales, p. ex. lasers à émission de surface à cavité horizontale [HCSEL]
H01S 5/11 - Structure ou forme du résonateur optique comprenant une structure de bande photonique interdite
H01S 5/343 - Structure ou forme de la région activeMatériaux pour la région active comprenant des structures à puits quantiques ou à superréseaux, p. ex. lasers à puits quantique unique [SQW], lasers à plusieurs puits quantiques [MQW] ou lasers à hétérostructure de confinement séparée ayant un indice progressif [GRINSCH] dans des composés AIIIBV, p. ex. laser AlGaAs
A measurement device (1) comprises: at least one light radiation unit (10) that radiates excitation light (EL) toward an interface between a culture solution (W) for expressing a target product substance and the inner surface of a culture container (2) holding the culture solution; a first imaging unit (dual-purpose imaging unit (12)) that captures an image of scattered light, which is the excitation light reflected at the interface, and acquires the image as a scattered light image; a second imaging unit (dual-purpose imaging unit (12)) that captures an image of fluorescence emitted by the expressed target product substance due to the radiation of the excitation light, and acquires the image as a fluorescence image; a fluorescence filter (13) that transmits light in a wavelength range including the wavelength of the fluorescence and restricts the transmission of light in at least the wavelength range of the excitation light; and a measurement unit (91) that measures the turbidity of the culture solution and the fluorescence intensity of the target product substance on the basis of the scattered light image and the fluorescence image.
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12M 1/02 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens d'agitationAppareillage pour l'enzymologie ou la microbiologie avec des moyens d'échange de chaleur
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
C12M 1/42 - Appareils pour le traitement de micro-organismes ou d'enzymes au moyen d'énergie électrique ou ondulatoire, p. ex. magnétisme, ondes sonores
A shaking device (10) is provided with: a shaking table (11) having a placement surface (11a) for placing a culture container accommodating a culture solution containing an object to be cultured; and a shaking mechanism (30) for shaking the shaking table in a plane parallel to the placement surface. The shaking mechanism comprises: a guide member (31) that movably supports the shaking table along a first axis (X axis) and a second axis (Y axis) that intersect each other in the plane parallel to the placement surface; a drive belt (32) that moves the shaking base along the first axis and the second axis; and a drive unit (33) that drives the drive belt. The drive unit drives the drive belt while independently controlling the movement of the shaking table along the first axis and the movement of the shaking table along the second axis.
C12M 1/02 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens d'agitationAppareillage pour l'enzymologie ou la microbiologie avec des moyens d'échange de chaleur
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12M 1/10 - Appareillage pour l'enzymologie ou la microbiologie montés rotativement
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
This method for detecting a target molecule in a liquid sample comprises: a step for mixing the liquid sample with a first hairpin probe that specifically binds to the target molecule, a second hairpin probe that performs a hybridization chain reaction with the first hairpin probe, and a double-stranded nucleic acid sequence-specific fluorescent dye that specifically binds to a specific double-stranded nucleic acid sequence and emits fluorescence, resultantly forming, when the target molecule is present, an amplification product of the first hairpin probe and the second hairpin probe by means of the hybridization chain reaction, and binding the double-stranded nucleic acid sequence-specific fluorescent dye to the specific double-stranded nucleic acid sequence contained in the amplification product; and a step for detecting fluorescence generated by irradiating the double-stranded nucleic acid sequence-specific fluorescent dye with excitation light.
A photoelectric conversion element (10) according to one embodiment of the present disclosure has a photoelectric conversion unit (1), wherein: the photoelectric conversion unit (1) has a light-receiving surface (1a); the photoelectric conversion unit (1) contains a ferroelectric semiconductor material; the ferroelectric semiconductor material is polarized in an in-plane direction of the light-receiving surface (1a), thereby breaking the spatial inversion symmetry of the photoelectric conversion unit (1); the ferroelectric semiconductor material contains one or both of a halogenated metal perovskite semiconductor material and a haolgenated perovskite semiconductor material containing formamidinium ions; and radiation light radiated onto the light-receiving surface (1a) is photoelectrically converted, thereby generating a photocurrent that flows in the polarization direction of the ferroelectric semiconductor material.
H10K 30/60 - Dispositifs organiques sensibles au rayonnement infrarouge, à la lumière, au rayonnement électromagnétique de plus courte longueur d'onde ou au rayonnement corpusculaire dans lesquels le rayonnement commande le flux de courant à travers les dispositifs, p. ex. photorésistances
H10F 10/00 - Cellules photovoltaïques individuelles, p. ex. cellules solaires
H10F 30/20 - Dispositifs individuels à semi-conducteurs sensibles au rayonnement dans lesquels le rayonnement commande le flux de courant à travers les dispositifs, p. ex. photodétecteurs les dispositifs ayant des barrières de potentiel, p. ex. phototransistors
To reduce the loss of superconductive passive elements, the superconductive passive element of the embodiment of the present disclosure includes a first conductor part having a deposited superconductor and a second conductor part having a superconductor. Here, the first conductor part is separated from the second conductor part, the outermost surface of the superconductor deposited on the first conductor part being opposite the second conductor part. Preferably, the superconductor of the second conductor part is one that has been deposited, and the first conductor part and the second conductor part are arranged with their respective outermost surfaces facing each other and separated from each, as in the superconductive passive element. In an embodiment of the present disclosure, a method for manufacturing the above superconductive passive element is also provided.
H01P 11/00 - Appareils ou procédés spécialement adaptés à la fabrication de guides d'ondes, résonateurs, lignes ou autres dispositifs du type guide d'ondes
A superconducting magnet device includes a low temperature vessel disposed in a cylindrical shape around a central axis so as to surround a sample region including the central axis, the low temperature vessel internally having a low temperature region, a winding frame having a cylindrical shape centered on the central axis and disposed in the low temperature region, a superconducting coil including a superconducting wire wound around an outer periphery of the winding frame, the superconducting coil being excited to generate a magnetic field, a shim coil that is arranged in the sample region and generates a magnetic field by being excited, a sample region magnetic shim disposed in the sample region and cooperating with the shim coil to increase homogeneity of a magnetic field of the sample region, and a low temperature magnetic shim in the low temperature region and enhances homogeneity of a magnetic field.
A spectroscopic device 1 comprises: a first atomic movement path 11 that is provided with an atom supply unit 10; a second atomic movement path 12 that, at a finite angle, intersects the first atomic movement path 11 at a first intersection position P1; a third atomic movement path 13 that, at a finite angle, intersects the second atomic movement path 12 at a second intersection position P2; and a clock laser light source 20 that supplies a clock laser L20 which propagates in a direction opposite to or the same as that of the movement of atoms on the second atomic movement path 12. A spectroscopic region SP where the clock laser L20 causes excitation of clock transition in atoms is formed between the first intersection position P1 and the second intersection position P2 on the second atomic movement path 12.
Provided is a gas measurement device for measuring a target gas present in soil. The gas measurement device comprises: one or more suction units that are buried in the soil and suck in gas; and a concentration measurement unit that measures concentration of the target gas contained in the gas that has been sucked in by the suction units. The gas measurement device also comprises a heating unit that heats at least a portion of a region in the soil from which the suction units suck in the gas, and the suction units may suck in the gas in the soil heated by the heating unit.
Provided are a structure and a reduction device capable of more efficiently generating hydride ions. A structure according to an embodiment of the present invention comprises a first electrode, a second electrode, and an electrolyte. The first electrode and the second electrode are porous and allow a fluid to pass therethrough. The electrolyte is a solid disposed between the first electrode and the second electrode. The electrolyte is electrically connected to the first electrode and the second electrode. Hydride ions can move through the electrolyte.
C25B 9/23 - Cellules comprenant des électrodes fixes de dimensions stablesAssemblages de leurs éléments de structure avec des diaphragmes comprenant des membranes échangeuses d'ions dans ou sur lesquelles est incrusté du matériau pour électrode
C25B 9/00 - Cellules ou assemblages de cellulesÉléments de structure des cellulesAssemblages d'éléments de structure, p. ex. assemblages d'électrode-diaphragmeCaractéristiques des cellules relatives aux procédés
This electron tube is provided with an electron emission unit including a metasurface from which electrons are emitted in response to entering of an electromagnetic wave having a predetermined electric field vibration direction, an electron multiplication unit that multiplies the electrons emitted from the electron emission unit, and a mesh electrode disposed between the electron emission unit and the electron multiplication unit. The mesh electrode includes a plurality of thin wires defining a plurality of openings arranged in a first direction parallel to the electric field vibration direction. When viewed in a traveling direction of the electromagnetic wave, each of the plurality of openings has an elongated shape of which the longitudinal direction corresponds to a second direction intersecting the first direction at an angle greater than or equal to 45 degrees.
A population of antibodies including homogeneous antibodies in which N-linked complex sugar chains attached to asparagine (Asn) at position 297 of CH domains of Fc regions of two heavy chains on the left and the right of each antibody are sugar chains structurally different from each other is described as well as a method of producing the population of antibodies.
The present invention provides a method for creating a health level positioning map, the method including: acquiring a first data set for a first parameter set, for each of a plurality of examinees; processing the first data set to obtain first data; mapping the processed first data for each of the plurality of examinees; clustering the mapped first data and thereby specifying a plurality of regions; and characterizing at least some of the plurality of regions.
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
G16H 50/70 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour extraire des données médicales, p. ex. pour analyser les cas antérieurs d’autres patients
20.
INFORMATION PROCESSING SYSTEM, INFORMATION PROCESSING METHOD, AND PROGRAM
NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM (Japon)
RIKEN (Japon)
Inventeur(s)
Takaishi, Masaki
Seki, Shota
Ujihara, Toru
Kutsukake, Kentaro
Abrégé
[Problem] To provide an information processing system and the like capable of optimizing an entire manufacturing line. [Solution] According to one aspect of the present invention, an information processing system is provided, the information processing system comprising a processor configured to execute following steps by reading a program, wherein the processor executes: a model acquisition step to acquire a pre-process model in which a pre-process for generating an intermediate product from a raw material is simulated, and a post-process model in which a post-process for generating a final product from the intermediate product is simulated; a condition acquisition step to acquire a process condition for each of the pre-process model and the post-process model; and an inference step to acquire, as an inference value, at least one of a characteristic value of the intermediate product, a characteristic value of the final product, a state value of a device used in the pre-process, and a state value of a device used in the post-process, by inputting the process conditions into a linked model in which at least the pre-process model and the post-process model are linked.
Provided are: a method for producing a spinal cord organoid from a pluripotent stem cell in vitro, the method comprising (1) a step for culturing a human pluripotent stem cell in a culture medium that contains a ROCK inhibitor and a Wnt signal activator but does not substantially contain a TGFβ inhibitor or a BMP signal inhibitor, (2) a step for further culturing the cell obtained in step (1) in a culture medium that contains a retinoic acid receptor agonist and a hedgehog signal activator, and (3) a step for further culturing the cell obtained in step (2) in a culture medium that does not substantially contain a TGFβ inhibitor, a BMP signal inhibitor, a retinoic acid receptor agonist, or a sonic hedgehog stimulator to obtain a spinal cord organoid; and a spinal cord organoid obtained by the method. The spinal cord organoid according to the present application comprises at least a portion of the dorsal side of the spinal cord and a ventral region of the spinal cord.
A01K 67/027 - Nouvelles races ou races modifiées de vertébrés
A61K 35/30 - NerfsCerveauYeuxCellules cornéennesLiquide céphalorachidienCellules souches neuronalesCellules précurseurs neuronalesCellules glialesOligodendrocytesCellules de SchwannAstrogliesAstrocytesPlexus choroïdeTissu de moelle épinière
A61L 27/36 - Matériaux pour prothèses ou pour revêtement de prothèses contenant des constituants de constitution indéterminée ou leurs produits réactionnels
A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
C12N 5/10 - Cellules modifiées par l'introduction de matériel génétique étranger, p. ex. cellules transformées par des virus
C12Q 1/02 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des micro-organismes viables
C25B 11/093 - Électrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau électro-catalytique formé d’au moins un élément catalytique et d’au moins un composé catalytiqueÉlectrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau électro-catalytique formé de plusieurs éléments catalytiques ou composés catalytiques au moins un métal noble ou oxyde de métal noble et au moins un oxyde d’un métal non noble
A pair of wheels (240) support a body part (100). A motor (210) rotates the pair of wheels (240). A weight member (220) is disposed such that a center of gravity B of the body part (100) is positioned vertically below a rotation axis A of the pair of wheels (240) when the body part (100) is in an upright state. The weight member (220) is fixed to a stator (211) of the motor (210), and is configured such that when torque is applied to the motor (210), torque required to rotate the pair of wheels (240) is generated around the rotation axis A.
Provided are: a novel electrode with relaxed and reduced restrictions on a use environment; a method for manufacturing the same; and a structure. The electrode according to the present invention contains: a metal nanowire; and a composite polymer of polyethylenedioxythiophene and an anionic fluorine-based polymer. The electrode has a single-layer structure or a layered structure. The composite polymer is contained at least in an outermost surface layer on the side opposite to a supported side. This method for manufacturing an electrode according to the present invention involves: a step for applying a first liquid containing the metal nanowire onto a surface to form a coating layer; and a step for applying a second liquid containing a solution of the composite polymer onto a surface of the coating layer to form the outermost surface layer.
A61B 5/268 - Électrodes bioélectriques à cet effet caractérisées par les matériaux des électrodes contenant des polymères conducteurs, p. ex. des polymères PEDOT:PSS
A terahertz wave generating device includes: a pump light source configured to generate pump light; a periodically poled element as a nonlinear optical element having a periodic structure in which a polarization or a crystal orientation is inverted at a certain inversion period; and a rotation stage configured to rotatably support the periodically poled element. The terahertz wave generating device causes the pump light to enter the periodically poled element to generate signal light that is a terahertz wave, and rotates the periodically poled element to change a wavelength of the signal light. The periodically poled element has an incident end face through which the pump light enters and an output end face through which the pump light exits. A rotation axis of the periodically poled element is closer to the incident end face than to the output end face.
National University Corporation Tokai National Higher Education and Research System (Japon)
Nagoya Institute of Technology (Japon)
RIKEN (Japon)
Inventeur(s)
Teramachi, Ryo
Furukawa, Taiki
Karasuyama, Masayuki
Yokota, Hideo
Abrégé
This information processing device is for predicting the prognosis of a subject patient affected by a disease, and includes a model acquisition unit, a subject patient information acquisition unit, and a prognosis prediction execution unit. The model acquisition unit acquires a prognosis prediction model, being a machine learning model that takes time-series information indicating a time-series transition of factors of the disease as an input, and outputs a prognosis of the disease. The subject patient information acquisition unit acquires time-series information about the subject patient. The prognosis prediction execution unit executes prognosis prediction of the subject patient using the time-series information about the subject patient and the prognosis prediction model, and outputs a result of the prognosis prediction.
G16H 50/50 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour la simulation ou la modélisation des troubles médicaux
28.
FLIGHT TIME MEASUREMENT METHOD AND FLIGHT TIME CORRECTION DEVICE
In the present invention, a target object is irradiated with a pulsed charged particle beam to generate neutrons with which a subject is irradiated, and as a result, the neutrons scattered at the subject are detected to determine the time of flight of each of the neutrons (step S5). The determined time of flight is corrected on the basis of delay time data for estimating a delay time related to the flight of each of the neutrons (step S6). The delay time data is obtained in advance on the basis of one or both of the pulse width of the pulsed charged particle beam and the deceleration characteristic of a moderator that decelerates the neutrons toward the subject (steps S1-S4).
G01N 23/204 - Recherche ou analyse des matériaux par l'utilisation de rayonnement [ondes ou particules], p. ex. rayons X ou neutrons, non couvertes par les groupes , ou en utilisant la diffraction de la radiation par les matériaux, p. ex. pour rechercher la structure cristallineRecherche ou analyse des matériaux par l'utilisation de rayonnement [ondes ou particules], p. ex. rayons X ou neutrons, non couvertes par les groupes , ou en utilisant la diffusion de la radiation par les matériaux, p. ex. pour rechercher les matériaux non cristallinsRecherche ou analyse des matériaux par l'utilisation de rayonnement [ondes ou particules], p. ex. rayons X ou neutrons, non couvertes par les groupes , ou en utilisant la réflexion de la radiation par les matériaux en mesurant la rétrodiffusion en utilisant des neutrons
An aerial image display device characterized by comprising a first optical element and a second optical element, which are configured such that a plurality of triangular ridges including a first inclined surface and a second inclined surface are arranged on a first surface, a second surface is a flat surface, and a light flux entering the first surface at a predetermined incident angle is transmitted through the first inclined surface, is reflected by the second inclined surface, and is emitted from the second surface, and characterized in that the first optical element and the second optical element are laminated such that the arrangement directions of the ridges are orthogonal to each other.
G02B 30/56 - Systèmes ou appareils optiques pour produire des effets tridimensionnels [3D], p. ex. des effets stéréoscopiques l’image étant construite à partir d'éléments d'image répartis sur un volume 3D, p. ex. des voxels en projetant une image aérienne ou flottante
G02B 5/00 - Éléments optiques autres que les lentilles
[Problem] To provide a new photoelectric conversion element in which scattering of carriers caused by light incident on a photoelectric conversion part is reduced, even at a high temperature equal to or higher than room temperature, and a current generated by movement of the carriers can be efficiently extracted from the photoelectric conversion part. [Solution] This photoelectric conversion element comprises: a photoelectric conversion part made of an organic nonlinear optical material and having no p-n junction; and first and second electrodes provided to the photoelectric conversion part and arranged with a space therebetween. The photoelectric conversion part is polarized in a direction aligned with the first and second electrodes and has a structure in which space inversion symmetry is broken.
C07D 213/38 - Radicaux substitués par des atomes d'azote liés par des liaisons simples comportant uniquement de l'hydrogène, ou des radicaux hydrocarbonés, liés à l'atome d'azote substituant
H10K 30/60 - Dispositifs organiques sensibles au rayonnement infrarouge, à la lumière, au rayonnement électromagnétique de plus courte longueur d'onde ou au rayonnement corpusculaire dans lesquels le rayonnement commande le flux de courant à travers les dispositifs, p. ex. photorésistances
H10K 85/60 - Composés organiques à faible poids moléculaire
In order to provide a THz-QCL element which takes advantage of the characteristics of a ZnO-based semiconductor material, a quantum cascade laser element has a semiconductor superlattice structure (a QCL structure), wherein the semiconductor superlattice structure has a plurality of unit structures that are stacked repeatedly. Each unit structures comprises three well layers having a composition of ZnO or ZnMgO, and barrier layers having a composition of ZnMgO or MgO that separates each well layer from each other and have a higher ratio of MgO than the left and right wells.
H01S 5/34 - Structure ou forme de la région activeMatériaux pour la région active comprenant des structures à puits quantiques ou à superréseaux, p. ex. lasers à puits quantique unique [SQW], lasers à plusieurs puits quantiques [MQW] ou lasers à hétérostructure de confinement séparée ayant un indice progressif [GRINSCH]
H01S 5/347 - Structure ou forme de la région activeMatériaux pour la région active comprenant des structures à puits quantiques ou à superréseaux, p. ex. lasers à puits quantique unique [SQW], lasers à plusieurs puits quantiques [MQW] ou lasers à hétérostructure de confinement séparée ayant un indice progressif [GRINSCH] dans des composés AIIBVI, p. ex. laser ZnCdSe
33.
METHOD AND APPARATUS FOR DETERMINING RISKS OF NEURODEGENERATIVE DISEASES
Provided is a method comprising acquiring representation abundances of multiple types of bacteria from analysis of salivary microbiota of a test subject; and inputting the acquired representation abundances into a prediction model to estimate risks of neurodegenerative diseases occurring in the test subject through stratification which differentiates multiple diseases, wherein the prediction model has been generated by machine learning which entails obtaining algorithm using, as explanatory variables, representation abundances of multiple types of bacteria acquired from analysis of salivary microbiota of healthy subjects and patients of multiple diseases belonging to the neurodegenerative diseases, and the disease states of the healthy subjects and the patients, output as target variables, as training data, wherein said multiple types of bacteria include bacteria types having high representation abundances and/or bacteria types showing significant differences in the representation abundances between patients of different diseases in the analysis of the salivary microbiota of the patients.
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
34.
INFORMATION-BASED KNOWLEDGE PRODUCTION DEVICE, INFORMATION-BASED KNOWLEDGE PRODUCTION METHOD, TRAINED MODEL, TRAINED MODEL GENERATION METHOD, AND PROGRAM
One aspect of the present invention is an information-based knowledge production device that comprises: a knowledge production vocabulary management unit that assigns unified meaning to information about different types of power systems in a machine-readable form and manages an ontology that defines a common vocabulary that is needed for knowledge production; and an information-based knowledge production unit that adds metadata that uses the common vocabulary of the ontology to individual pieces of information and produces knowledge from the information.
H02J 13/00 - Circuits pour pourvoir à l'indication à distance des conditions d'un réseau, p. ex. un enregistrement instantané des conditions d'ouverture ou de fermeture de chaque sectionneur du réseauCircuits pour pourvoir à la commande à distance des moyens de commutation dans un réseau de distribution d'énergie, p. ex. mise en ou hors circuit de consommateurs de courant par l'utilisation de signaux d'impulsion codés transmis par le réseau
The present invention provides a method for producing regenerated hair follicle primordium that allows production of regenerated hair follicle primordium more easily and in larger amounts compared to conventional production methods.
The present invention provides a method for producing regenerated hair follicle primordium that allows production of regenerated hair follicle primordium more easily and in larger amounts compared to conventional production methods.
A method for producing regenerated hair follicle primordium comprising a step of obtaining hair follicle primordium by culturing a first population of cells comprising epithelial cells and a second population of cells comprising mesenchymal cells while allowing them to be in contact is provided. The production method of the present invention is characterized in that at least either one of said first population of cells and said second population of cells has formed cell aggregates before said contact, and a culture support is not used when contacting the other population of cells with said cell aggregate.
The present invention provides a method for producing regenerated hair follicle primordium that allows production of regenerated hair follicle primordium more easily and in larger amounts compared to conventional production methods.
The present invention provides a method for producing regenerated hair follicle primordium that allows production of regenerated hair follicle primordium more easily and in larger amounts compared to conventional production methods.
A method for producing regenerated hair follicle primordium comprising a step of obtaining hair follicle primordium by culturing a first population of cells comprising epithelial cells and a second population of cells comprising mesenchymal cells while allowing them to be in contact is provided. The production method of the present invention is characterized in that at least either one of said first population of cells and said second population of cells has formed cell aggregates before said contact, and a culture support is not used when contacting the other population of cells with said cell aggregate.
The present invention provides a method for producing regenerated hair follicle primordium that allows production of regenerated hair follicle primordium more easily and in larger amounts compared to conventional production methods.
The present invention provides a method for producing regenerated hair follicle primordium that allows production of regenerated hair follicle primordium more easily and in larger amounts compared to conventional production methods.
A method for producing regenerated hair follicle primordium comprising a step of obtaining hair follicle primordium by culturing a first population of cells comprising epithelial cells and a second population of cells comprising mesenchymal cells while allowing them to be in contact is provided. The production method of the present invention is characterized in that at least either one of said first population of cells and said second population of cells has formed cell aggregates before said contact, and a culture support is not used when contacting the other population of cells with said cell aggregate.
VECTOR SET USED FOR TARGETING SPECIFIC NEURON POPULATION IN NEURAL CIRCUIT, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND METHOD FOR TARGETING SPECIFIC NEURON POPULATION IN NEURAL CIRCUIT
The purpose of the present invention is to provide a novel method for targeting a neuron population that is a neural circuit element which has more limited functional localization. The purpose of the present invention is also to provide a method for treating a disease or the like by targeting a specific neuron population involved in a disease or the like by said novel method and controlling the neural activity thereof. The present invention is a vector set used for targeting a specific neuron population in a neural circuit, said vector set being characterized by comprising first to third vectors, wherein: the first vector is an antegrade trans-synaptic virus vector that contains a base sequence which codes for a split-Cre recombinase consisting of a C-terminal-side sequence of a Cre recombinase; the second vector is a retrograde trans-synaptic virus vector that contains a base sequence which codes for a split-Cre recombinase consisting of an N-terminal-side sequence of a Cre recombinase; the third vector is a non-trans-synaptic virus vector that contains an inverted sequence of a gene sequence which codes for a desired protein and that has a loxP sequence and a loxP mutation sequence which face opposite to each other and which are at both ends of the inverted sequence; and a functional Cre recombinase is formed in a cell that has been infected with the first vector and the second vector.
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
This electromagnetic wave detection device 10 comprises an electromagnetic wave transmitter 11, an electromagnetic wave detector 12, a waveform deformation unit 13, a control device 15, a reference signal generation unit 14a, a waveform generation unit 16, and a synchronous detection unit 14b. The electromagnetic wave transmitter 11 transmits electromagnetic waves to a sample 1, and the electromagnetic wave detector 12 detects electromagnetic waves that have interacted with the sample 1 and outputs an electric signal. The reference signal generation unit 14a generates a reference signal with a frequency that is a natural number multiple of a standard frequency, the natural number multiple being at least two. The waveform deformation unit 13, 23 deforms the waveforms of either one or both of the electric signal and the reference signal. After this waveform deformation, the synchronous detection unit 14b synchronously detects the electrical signal with the reference signal and outputs a detection signal.
G01N 21/3586 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge en utilisant la lumière de l'infrarouge lointainCouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge en utilisant un rayonnement térahertz par spectroscopie térahertz dans le domaine temporel [THz-TDS]
G01N 21/33 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière ultraviolette
G01N 21/35 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge
G01N 22/00 - Recherche ou analyse des matériaux par l'utilisation de micro-ondes ou d'ondes radio, c.-à-d. d'ondes électromagnétiques d'une longueur d'onde d'un millimètre ou plus
G01N 23/02 - Recherche ou analyse des matériaux par l'utilisation de rayonnement [ondes ou particules], p. ex. rayons X ou neutrons, non couvertes par les groupes , ou en transmettant la radiation à travers le matériau
The present disclosure relates to a factor pertaining to autoimmune diseases such as inflammatory bowel disease (IBD) (e.g., ulcerative colitis (UC)). The present disclosure provides a composition for adjusting an immune state or for preventing or treating autoimmune/inflammatory diseases, the composition including a means for altering or maintaining N-acyloxyacyl ornithine (NAAO) to/at an appropriate level. The present disclosure also provides: a method for preventing or treating inflammatory diseases, disorders, or disease symptoms, the method comprising activating MRGPRX4, Mrgprb5, or an ortholog thereof; a related medicine; a medical device; and the like.
A61K 31/198 - Alpha-amino-acides, p. ex. alanine ou acide édétique [EDTA]
A61K 31/7088 - Composés ayant au moins trois nucléosides ou nucléotides
A61K 35/12 - Substances provenant de mammifèresCompositions comprenant des tissus ou des cellules non spécifiésCompositions comprenant des cellules souches non embryonnairesCellules génétiquement modifiées
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
A61P 1/04 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des ulcères, des gastrites ou des œsophagites par reflux, p. ex. antiacides, antisécrétoires, protecteurs de la muqueuse
A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
A61P 37/06 - Immunosuppresseurs, p. ex. médicaments pour le traitement du rejet de greffe
C12N 1/15 - ChampignonsLeurs milieux de culture modifiés par l'introduction de matériel génétique étranger
C12N 1/19 - LevuresLeurs milieux de culture modifiés par l'introduction de matériel génétique étranger
Disclosed herein are improved in vitro methods of making splanchnic mesoderm cell types and subtypes thereof from pluripotent cells. These methods can be used to produced improved foregut- and hindgut-derived organoids containing enriched mesenchyme, which enhances organoid viability, growth, and maturation, both in in vitro culture and in vivo transplantation.
A tissue transplantation resin tip includes a needle tube for eyeball insertion. The needle tube includes a main body portion that extends linearly. A front end portion is bent with respect to the main body portion and extends linearly, with tissue discharging from the front end. The needle tube length is 25 mm to 50 mm, the front end portion cross sectional shape is oval with a major axis D1 of 0.8 mm to 1.5 mm and a minor axis D2 of 0.5 mm to 1.0 mm. The front end of the front end portion is a bevel surface that extends in a direction substantially perpendicular to the main body portion and has a bevel angle of 50° to 85°. The front end portion hardness is 0.15 N to 0.30 N or less and the center of the needle tube hardness is 0.80 N to 1.50 N.
Provided is a building inside structure recognition system for recognizing a structure in a building by using a machine learning model. A building inside structure recognition system according to the present invention comprises: a machine learning model generation device that generates a machine learning model by executing machine learning in which a correct image generated from building information modeling (BIM) data is set as correct data and a virtually observed image generated by rendering the BIM data is set as observation data; and a building inside structure recognition device that recognizes a structure in a building by using the machine learning model generated by the machine learning model generation device.
G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
G06V 10/46 - Descripteurs pour la forme, descripteurs liés au contour ou aux points, p. ex. transformation de caractéristiques visuelles invariante à l’échelle [SIFT] ou sacs de mots [BoW]Caractéristiques régionales saillantes
G06V 10/77 - Traitement des caractéristiques d’images ou de vidéos dans les espaces de caractéristiquesDispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant l’intégration et la réduction de données, p. ex. analyse en composantes principales [PCA] ou analyse en composantes indépendantes [ ICA] ou cartes auto-organisatrices [SOM]Séparation aveugle de source
44.
SAMPLE LIQUID CONCENTRATION DEVICE, SAMPLE LIQUID ANALYSIS AUXILIARY DEVICE, METHOD FOR PRODUCING SAME, AND SAMPLE LIQUID CONCENTRATION METHOD
In order to increase the efficiency with which an analysis using an enhanced electric field based on a microstructure is made, an embodiment of the present disclosure provides a plate-shaped sample liquid concentration device (10) that is to be used being placed over a microstructure substrate which has disposed on the surface thereof a microstructure capable of generating an enhanced electric field with respect to incident light. The sample liquid concentration device includes a first surface and a second surface that defines a thickness together with the first surface, and has formed therein a plurality of passage parts connecting the first surface and the second surface. The passage parts each have a first opening and a second opening formed respectively in the first surface and the second surface and are each defined by an inner surface connecting the first opening and the second opening. With the first surface disposed in proximity to the surface of the microstructure substrate, the first opening can be positioned corresponding to the position of the microstructure. The second opening can receive a sample liquid that contains a detection target object.
INTER-UNIVERSITY RESEARCH INSTITUTE CORPORATION NATIONAL INSTITUTES OF NATURAL SCIENCES (Japon)
Inventeur(s)
Ebizuka, Noboru
Hosobata, Takuya
Takeda, Masahiro
Yamagata, Yutaka
Motohara, Kentaro
Okuma Konishi, Masahiro
Matsubayashi, Kazuya
Kushibiki, Kosuke
Okamoto, Takayuki
Abrégé
[Problem] To miniaturize an optical device. In particular, provided is a miniaturized grism which is a high-performance grism that achieves higher angular dispersion (wavelength resolution) under the condition of retaining the same size and refractive index, or having a smaller refractive index. [Solution] A grism is provided with: a prism and a prism array, or two prism arrays; and a transmission-type grating arranged between the prism and the prism array or between the two prism arrays.
A method for producing a polymer having a repeating unit represented by formula (1) (in formula (1), R represents a hydrogen atom or an acetyl group), the method comprising a step for bringing PKS2 or a PKS2 homolog, PBG13 or a PBG13 homolog, and reduced nicotinamide adenine dinucleotide phosphate (NADPH) into contact with a substrate to obtain the polymer, wherein the substrate is malonyl-CoA, or malonyl-CoA and acetyl-CoA.
Provided is a superconducting magnet device comprising: a winding frame; a superconducting coil that is configured by winding a tape-shaped superconducting wire on the winding frame; and a buffer member that suppresses torsional deformation which is caused by flow of a transport current to the superconducting coil.
A tissue cell parameter processing device (101) estimates a tissue cell parameter from images obtained by imaging an affected area. In this estimation, a reception unit (102) receives a low-load image obtained by imaging the affected area under a low-load condition. A generation unit (103) feeds the low-load image as input into a trained generative model, and thus generates a high-load image that would be obtained by imaging the affected area under a high-load condition. An estimation unit (104) estimates a tissue cell parameter pertaining to the affected area from the high-load image. A control unit (105), which can be omitted, executes the processing by the reception unit (102), the generation unit (103), and the estimation unit (104) on a plurality of low-load images respectively obtained by imaging the affected area at different times, so that the tissue cell parameter at the different times is estimated. A prediction unit (106), which can be omitted, feeds the tissue cell parameter at the different times as input into a trained predictive model, and thus interpolates and predicts temporal changes in the tissue cell parameter.
G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
G06V 20/69 - Objets microscopiques, p. ex. cellules biologiques ou pièces cellulaires
49.
METHOD AND KIT FOR PREDICTING EFFECTIVENESS OF DUPILUMAB ADMINISTRATION TO ATOPIC DERMATITIS PATIENT
This method for predicting the effectiveness of dupilumab administration to an atopic dermatitis patient comprises a step for measuring the concentration of at least one biomarker in a blood sample derived from the patient before dupilumab administration, wherein: the concentration of the biomarker is an indicator for predicting the effectiveness of the dupilumab administration; and the biomarker is selected from the group consisting of interleukin (IL)-22, C-C Motif Chemokine Ligand (CCL) 20, IL-18, IL-17, Tumor Necrosis Factor (TNF)-α, and C-X-C Motif Chemokine 9 (CXCL9).
G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
A61P 17/00 - Médicaments pour le traitement des troubles dermatologiques
C07K 16/24 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des cytokines, des lymphokines ou des interférons
C12N 15/115 - Aptamères, c.-à-d. acides nucléiques liant spécifiquement une molécule cible avec une haute affinité sans s'y hybrider
50.
METHOD FOR IDENTIFYING FUNCTIONAL CELL SUBPOPULATIONS IN MESENCHYMAL/STEM CELL POPULATIONS
JAPAN AS REPRESENTED BY DIRECTOR GENERAL OF NATIONAL INSTITUTE OF HEALTH SCIENCES (Japon)
KANAGAWA INSTITUTE OF INDUSTRIAL SCIENCE AND TECHNOLOGY (Japon)
RIKEN (Japon)
Inventeur(s)
Sato, Yoji
Miura, Takumi
Takano, Megumi
Umezawa, Akihiro
Kawai, Jun
Kouno, Tsukasa
Ito, Masayoshi
Abrégé
The present invention provides a method for identifying functional cell subpopulations in an MSCs cell population, the method comprising performing omics analysis of an MSCs cell population at the single cell level and clustering the MSCs cell population based on the results of the analysis to classify the cell population into cell subpopulations.
Provided is: an oxygen generating electrode in which a high electrolytic current density can be obtained even with a content of a noble metal within a certain range, the oxygen generating electrode comprising a catalyst containing an iridium-containing manganese oxide combined with a conductive base material containing platinum; and/or a water electrolysis method using the electrode. The oxygen generating electrode comprises a conductive base material and a catalyst containing an iridium-containing manganese oxide. The conductive base material contains platinum, the total of the amount of iridium per geometric area of the oxygen generating electrode and the amount of platinum per geometric area of the oxygen generating electrode is above 0.1 mg/cm2and 6.1 mg/cm2 or less, and the ratio of the amount of platinum per geometric area of the oxygen generating electrode to the amount of iridium per geometric area of the oxygen generating electrode is 1 or more and less than 600.
C25B 11/093 - Électrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau électro-catalytique formé d’au moins un élément catalytique et d’au moins un composé catalytiqueÉlectrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau électro-catalytique formé de plusieurs éléments catalytiques ou composés catalytiques au moins un métal noble ou oxyde de métal noble et au moins un oxyde d’un métal non noble
C25B 11/053 - Électrodes comportant un substrat et un ou plusieurs revêtements électro-catalytiques caractérisées par des revêtements électro-catalytiques multicouches
C25B 11/054 - Électrodes comportant des électro-catalyseurs sur un support
52.
Magnetic Optical Trap Device, Physics Package, Physics Package for Optical Lattice Clock, Physics Package for Atomic Clock, Physics Package for Atomic Interferometer, Physics Package for Quantum Information Processing Device, and Physics Package System
According to the present invention, atoms are trapped by a quadrupole magnetic field formed by ring-shaped magnets and three sets of laser beam pairs. A portion of the laser beam pairs is partially blocked by the ring-shaped magnets, , so that a region which is a non-atom trap space is formed inside an intersecting region where the three groups of laser beam pairs cross. The inside of the intersecting region is irradiated with a laser beam so that atoms within the non-atom catch space are extracted from the intersecting region.
G21K 1/00 - Dispositions pour manipuler des particules ou des rayonnements ionisants, p. ex. pour focaliser ou pour modérer
G04F 5/14 - Appareils pour la production d'intervalles de temps prédéterminés, utilisés comme étalons utilisant des horloges atomiques
H03L 7/26 - Commande automatique de fréquence ou de phaseSynchronisation utilisant comme référence de fréquence les niveaux d'énergie de molécules, d'atomes ou de particules subatomiques
53.
METHOD AND KIT FOR PREDICTING EFFICACY OF DUPILUMAB ADMINISTRATION TO ATOPIC DERMATITIS PATIENT
Provided is a method for predicting the efficacy of dupilumab administration to an atopic dermatitis patient, the method comprising a step for measuring the expression level of at least one biomarker in a skin tissue sample from the patient prior to dupilumab administration, wherein the expression level of the biomarker is an indicator for predicting the efficacy of dupilumab administration.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
A61P 17/00 - Médicaments pour le traitement des troubles dermatologiques
C12Q 1/6876 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
54.
METHOD FOR PRODUCING RETINAL TISSUE AND RETINA-RELATED CELLS
The present invention provides a method for producing a retinal progenitor cell, including (1) a first step of subjecting pluripotent stem cells to floating culture in a serum-free medium to form an aggregate of pluripotent stem cells, and (2) a second step of subjecting the aggregate formed in step (1) to floating culture in a serum-free medium or serum-containing medium each being free of a substance acting on the Sonic hedgehog signal transduction pathway but containing a substance acting on the BMP signal transduction pathway, thereby obtaining an aggregate containing retinal progenitor cells.
Provided are a small animal excreta recovery device and a small animal rearing cage equipped with the small animal excreta recovery device. This small animal excreta recovery device comprises: a rotation mechanism that, for each preset set time, rotates a disk-shaped turntable having a container for accommodating excreta; and a distribution mechanism that distributes a member for closing the container accommodating the excreta.
To provide a surface-emitting quantum cascade laser that can easily achieve high power with low divergence operation, the PhC-QCL element of the present disclosure has a first electrode, which is a film extending beyond a certain range, a semiconductor superlattice structure, and a second electrode disposed on or above the semiconductor superlattice structure. The semiconductor superlattice structure has an active region comprising a plurality of unit structures that are repeatedly stacked. The second electrode has an array of apertures that forms, for example, a triangular lattice. The second electrode has no electrically isolated areas in the range. Preferably, the active region is provided with column holes shaped to match the openings in the second electrode as a similar triangular lattice arrangement.
H01S 5/34 - Structure ou forme de la région activeMatériaux pour la région active comprenant des structures à puits quantiques ou à superréseaux, p. ex. lasers à puits quantique unique [SQW], lasers à plusieurs puits quantiques [MQW] ou lasers à hétérostructure de confinement séparée ayant un indice progressif [GRINSCH]
The present invention provides a model mouse. A model mouse according to the present invention has at least the following three or four mutations in the microtubule-binding protein Tau (MAPT): (i) a mutation of an amino acid residue that corresponds to the 320th serine residue of human MAPT, (ii) a mutation of an amino acid residue that corresponds to the 305th serine residue of human MAPT and/or a mutation of an amino acid residue that corresponds to the 301st proline residue of human MAPT, and (iii) a mutation in an intron that corresponds to intron 10 in the gene that codes for human MAPT.
A01K 67/0275 - Vertébrés modifiés génétiquement, p. ex. transgéniques
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
C12N 15/12 - Gènes codant pour des protéines animales
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
58.
WAVELENGTH-VARIABLE LIGHT SOURCE AND WAVELENGTH CONTROL METHOD
A wavelength-variable light source (1) comprises: an oscillation unit (2) that oscillates light; first light output units (4, 5, 6) that variably change the wavelength of the light oscillated by the oscillation unit and output first light having a wavelength in a first wavelength band; a second light optical path (21) that propagates second light having a wavelength different from the first light; and a sum frequency light generation unit (8) that includes a nonlinear optical crystal and combines the first light (L1) output by the first light output units and the second light (L2) propagated in the second light optical path on the same optical axis, causes the combined light to enter the nonlinear optical crystal, and emits sum frequency light (L3) having a wavelength in a second wavelength band shorter than the first wavelength band from the nonlinear optical crystal by sum frequency generation.
The present invention addresses the problem of providing a method with which plants that are not currently used for food, or parts of said plants, are made edible. The present invention also addresses the problem of providing a method for improving the taste of plants that are used for food, or parts of said plants. Provided is a crop or a food/beverage that is made of a plant in which the expression and/or activity of a jasmonic acid defense-related protein is suppressed or inhibited, or part of said plant, or that contains any one thereof, the crop being an edible crop or a feed crop for animals excluding Agromyzidae, and the food/beverage being for humans or being feed for animals excluding Agromyzidae.
A01H 5/00 - Angiospermes, c.-à-d. plantes à fleurs, caractérisées par leurs parties végétalesAngiospermes caractérisées autrement que par leur taxonomie botanique
A01H 6/00 - Angiospermes, c.-à-d. plantes à fleurs, caractérisées par leur taxonomie botanique
A01H 6/20 - Brassicaceae, p. ex. colza, brocoli ou roquette
A01H 6/82 - Solanaceae, p. ex. poivron, tabac, pomme de terre, tomate ou aubergine
A23K 10/30 - Produits alimentaires pour animaux à base de matières d’origine végétale, p. ex. de racines, de graines ou de foinProduits alimentaires pour animaux à base de matières d’origine fongique, p. ex. de champignons
A23L 35/00 - Aliments ou produits alimentaires non prévus par les groupes Leur préparation ou leur traitement
The present disclosure provides a composition having NKT cell activation ability that contains cells incubated with a CD1d ligand prior to CD1d introduction. The present disclosure also provides a composition comprising cells, wherein the cells are human-derived cells and express a complex of CD1d and CD1d ligand on the cell surface and in the cell, respectively, and the amount of the complex in the cells is significantly greater than the amount of the complex on the cell surface. The present disclosure further provides a composition capable of further expressing an antigen and further inducing antigen-specific immunity.
C12N 5/10 - Cellules modifiées par l'introduction de matériel génétique étranger, p. ex. cellules transformées par des virus
A61K 35/12 - Substances provenant de mammifèresCompositions comprenant des tissus ou des cellules non spécifiésCompositions comprenant des cellules souches non embryonnairesCellules génétiquement modifiées
C09K 11/06 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances organiques luminescentes
C12Q 1/34 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase
C12Q 1/37 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase faisant intervenir une peptidase ou une protéinase
G01N 21/78 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique produisant un changement de couleur
62.
NON-TRANSITORY COMPUTER-READABLE RECORDING MEDIUM, PREDICTION METHOD, TRAINING METHOD, AND INFORMATION PROCESSING APPARATUS
A non-transitory computer-readable recording medium has stored therein a prediction program that causes a computer to execute a process including inputting input data of reference timing and information of a lapse of time to a trained self-encoder, predicting an output from the trained self-encoder as noiseless data corresponding to the input data of the reference timing wherein the trained self-encoder has been trained such that an output in a case where data of a reference timing included in training data and information of a lapse of time are input approaches data of a timing corresponding to information of the lapse of time.
In order to set a target value for a physical quantity of an object to be controlled, an acquisition unit (102) in a control device (101) acquires a physical quantity pertaining to an object to be observed and a time differential of the physical quantity pertaining to the object to be observed. A calculation unit (103) calculates the sum of the acquired physical quantity and the product of the acquired time differential and a prediction coefficient. A setting unit (104) sets, as the target value for the physical quantity pertaining to the object to be controlled, an upper limit value if the calculated sum exceeds the upper limit value, a lower limit value if the calculated sum is less than the lower limit value, and the calculated sum if the calculated sum is equal to or greater than the lower limit value and equal to or less than the upper limit value. The control device (101) repeats the acquisition by the acquisition unit (102), the calculation by the calculation unit (103), and the setting by the setting unit (104).
G05B 11/36 - Commandes automatiques électriques avec les dispositions nécessaires pour obtenir des caractéristiques particulières, p. ex. proportionnelles, intégrales, différentielles
The present invention provides: a fluorinated compound in which a group represented by general formula (1) (wherein n represents an integer of 1-7; and the black dot represents a bond) is linked, via a linking group, to a functional molecule that acts in cells, and the functional molecule is a low-molecular-weight compound having a molecular weight of 200-1,000 Da; a pharmaceutical composition which contains the fluorinated compound; and a method for transporting a fluorinated compound in cells, the method comprising culturing cells in a culture medium containing the fluorinated compound to transport the fluorinated compound into the cells.
A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique
C09K 11/06 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances organiques luminescentes
C12N 5/071 - Cellules ou tissus de vertébrés, p. ex. cellules humaines ou tissus humains
C12Q 1/02 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des micro-organismes viables
65.
METHOD FOR PRODUCING CHAIN UNSATURATED CARBOXYLIC ACID COMPOUND USING PHENYLALANINE AMMONIA LAYSE
A method for producing a chain-shaped unsaturated carboxylic acid compound or a geometric isomer thereof, having at least two carbon-carbon double bonds, including the steps of: removing, from a chain-shaped unsaturated carboxylic acid compound or a geometric isomer thereof having an amino group and a carbon-carbon double bond at a terminus, that amino group, in the presence of phenylalanine ammonia lyase, and further forming a carbon-carbon double bond.
An object of the present invention is to provide a fluorescent probe that can be used in an enzyme activity detection method. According to the present invention, there is provided a fluorescent probe for detecting a hydrolase, the fluorescent probe containing a compound having at least one water-soluble substituent selected from the group consisting of —CO2H, —PO3H2, and —SO3H and represented by General Formula (II), or a salt thereof. The fluorescent probe of the present invention can be used in an enzyme activity detection method using a microdevice.
An object of the present invention is to provide a fluorescent probe that can be used in an enzyme activity detection method. According to the present invention, there is provided a fluorescent probe for detecting a hydrolase, the fluorescent probe containing a compound having at least one water-soluble substituent selected from the group consisting of —CO2H, —PO3H2, and —SO3H and represented by General Formula (II), or a salt thereof. The fluorescent probe of the present invention can be used in an enzyme activity detection method using a microdevice.
C12Q 1/37 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase faisant intervenir une peptidase ou une protéinase
C09K 11/06 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances organiques luminescentes
The present disclosure relates to: a labeled collagen IVα1 protein; a labeled collagen IVα2 protein; nucleic acids encoding said proteins; and animals having said nucleic acids. The present disclosure also relates to a method for observing the labeled collagen IVα1 protein or the labeled collagen IVα2 protein in the animals.
Provided is a method for inducing the differentiation of pluripotent stem cells which are obtained by suspension culture with high quality and/or high efficiency. The present invention pertains to a method for producing differentiated cells, the method comprising: a step in which thermal stimulation is applied to pluripotent stem cells after suspension culture of the pluripotent stem cells; a step in which the pluripotent stem cells are subsequently seeded in a culture medium that is different from a culture medium used in the suspension culture; and a step in which agregate mass formation and differentiation induction of the seeded pluripotent stem cells are performed.
This fluorescence observation device comprises: an excitation light source that irradiates an observation target with excitation light; an imaging unit that captures an observation image using fluorescence emitted by the observation target excited by the excitation light; a light guide optical system that guides the fluorescence to the imaging unit; a fluorescence filter that is disposed on the light incident side of the light guide optical system and transmits light in a wavelength range including the wavelength of the fluorescence; and a light shielding member disposed on the light incident side of the fluorescence filter. The light shielding member shields light incident on the fluorescence filter from a direction intersecting the normal of the fluorescence filter.
This method for determining the risk of a subject developing heart failure is characterized by: including a step for preparing a data list including effect alleles and effect sizes of genetic polymorphism, a step for acquiring genetic information on the subject, a step for calculating a heart failure risk score from genetic information of the subject based on information pertaining to effect alleles and effect sizes of genetic polymorphism in the data list, and a step for determining the risk of heart failure based on the risk score; the data list including genomic analysis results for heart failure in a European and American population, genomic analysis results for heart failure in a population other than Europeans and Americans, genomic analysis results on measurement values related to heart failure subtype, and genomic analysis results on diseases related to heart failure; and the risk score being a combination of the risk scores calculated from these data lists.
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
71.
VARIABLE-WAVELENGTH LIGHT SOURCE AND VARIABLE-WAVELENGTH METHOD
This variable-wavelength light source includes: a light output unit that outputs light, the wavelength of the outputted light being variable; a first optical amplification unit that amplifies the light outputted by the light output unit; a filter unit that filters the light amplified by the first optical amplification unit; and a second optical amplification unit that amplifies the light filtered by the filter unit. The first optical amplification unit has a gain on a first-wavelength side that is higher than the gain on a second-wavelength side, the second wavelength being different from the first wavelength. The second optical amplification unit has a gain on the second-wavelength side that is higher than the gain on the first-wavelength side. The filter unit attenuates the natural radiation amplified light.
H01S 3/10 - Commande de l'intensité, de la fréquence, de la phase, de la polarisation ou de la direction du rayonnement, p. ex. commutation, ouverture de porte, modulation ou démodulation
G02F 1/365 - Optique non linéaire dans une structure de guide d'ondes optique
H01S 3/23 - Agencement de plusieurs lasers non prévu dans les groupes , p. ex. agencement en série de deux milieux actifs séparés
72.
WAVELENGTH CONVERSION OPTICAL SYSTEM AND PULSE LIGHT GENERATION DEVICE
This wavelength conversion optical system includes: a wavelength conversion element in which different light incident positions have different wavelength conversion bands; and a wavelength-specific optical path setting unit for adjusting an optical path for each wavelength band so that light to be converted to the intended wavelength band hits the corresponding incident position in the wavelength conversion element.
A scanning microscope disclosed herein comprises: a pulse light generation device (or a pulse light generation device) that emits excitation light toward a sample, wherein the excitation wavelength of the excitation light is switched for each pulse; and a detector that detects fluorescence from a cell mass S irradiated with the excitation light and outputs a detection signal. The sensor bandwidth of the detector is adjusted so that the detection signal attenuates within a pulse-off period of the excitation light.
H01S 3/00 - Lasers, c.-à-d. dispositifs utilisant l'émission stimulée de rayonnement électromagnétique dans la gamme de l’infrarouge, du visible ou de l’ultraviolet
The purpose of the present invention is to provide a polymer blend exhibiting excellent marine biodegradability even when containing a biodegradable resin having poor biodegradability in a marine environment. The present invention provides a marine biodegradable polymer blend comprising: a polyester-based polymer A having a structural unit (A) derived from a succinic acid, a structural unit (B) derived from a C7 or higher dicarboxylic acid, and a structural unit (C) derived from an aliphatic diol; and a biodegradable polymer B, wherein the polyester-based polymer A and the biodegradable polymer B are in a compatible or incompatible state.
A pulse light generation device 1 comprises: an oscillator 2 for oscillating an ultrashort pulse light L; a stretcher fiber 7 for widening the time width of the ultrashort pulse light L; a fiber amplifier 8 for amplifying the ultrashort pulse light L the time width of which has been widened by the stretcher fiber 7; and a compressor 9 for compressing the time width of the ultrashort pulse light L which has been amplified by the fiber amplifier 8. The stretcher fiber 7 is configured by combining a first fiber 71 for widening the time width of the ultrashort pulse light L with a first characteristic, and a second fiber 72 for widening the time width of the ultrashort pulse light L with a second characteristic which is different from the first characteristic.
H01S 3/10 - Commande de l'intensité, de la fréquence, de la phase, de la polarisation ou de la direction du rayonnement, p. ex. commutation, ouverture de porte, modulation ou démodulation
G02F 1/11 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p. ex. commutation, ouverture de porte ou modulationOptique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur basés sur des éléments acousto-optiques, p. ex. en utilisant la diffraction variable par des ondes sonores ou des vibrations mécaniques analogues
The present invention provides: an agent for reducing the concentration of a protein in blood, the agent containing Pediococcus acidilactici; and a food, a feed, and a medicine each of which is for reducing the concentration of a protein in blood and contains the agent for reducing the concentration of a protein in blood or Pediococcus acidilactici.
A23L 33/135 - Bactéries ou leurs dérivés, p. ex. probiotiques
A23K 10/16 - Ajout de micro-organismes ou de leurs produits d’extraction, p. ex. de protéines provenant d’organismes unicellulaires, à des compositions de produits alimentaires
A61K 35/744 - Bactéries lactiques, p. ex. entérocoques, pédiocoques, lactocoques, streptocoques ou leuconostoques
A61P 3/00 - Médicaments pour le traitement des troubles du métabolisme
A61P 7/00 - Médicaments pour le traitement des troubles du sang ou du fluide extracellulaire
A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes
77.
POLYNUCLEOTIDE FOR TREATMENT OF NEURODEGENERATIVE DISEASE, VECTOR, CELL, PHARMACEUTICAL COMPOSITION, AND SCREENING METHOD
The purpose of the present invention is to provide a novel method for increasing the number of newly generated neurons in the adult brain, and to provide a polynucleotide, a vector, and a pharmaceutical composition for use in the method. The present invention provides: a polynucleotide characterized by including (A) the nucleic acid sequence of the Plagl2 gene, (B) an miR-shRNA (microRNA adapted short hairpin RNA) nucleic acid sequence for the Dyrk1a gene, and (C) a promoter sequence operatively connected to the nucleic acid sequences; a vector including the polynucleotide; and a pharmaceutical composition including the polynucleotide and the vector.
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
To improve the luminous efficiency of a UV light-emitting device, the UV light-emitting devices disclosed herein have an AlGaN-based crystal or an InAlGaN-based crystal, and comprise an emission layer, at least one electron blocking layer, a first p-type doped layer, and a composition gradient layer in which the Al composition ratio varies depending on the position over a thickness direction of the layer stack, stacked in this order in the direction of the flow of electrons. The Al composition ratio varies depending on the position over the thickness direction in the composition gradient layer. The UV light-emitting devices are implemented as UV-region light-emitting diodes and laser diodes.
H10H 20/816 - Corps ayant des structures contrôlant le transport des charges, p. ex. couches semi-conductrices fortement dopées ou structures bloquant le courant
H10H 20/825 - Matériaux des régions électroluminescentes comprenant uniquement des matériaux du groupe III-V, p. ex. GaP contenant de l’azote, p. ex. GaN
A quantum device includes a filter having a plurality of notches in a first frequency band lower than a second frequency band, a first qubit that resonates in the first frequency band, and a second qubit that resonates in the second frequency band. The first qubit is input with a signal having a frequency at which the first qubit resonates via the filter to control a state of the first qubit when executing a one-qubit gating, and is input with a signal having a frequency at which the second qubit resonates via the filter to control a state of the second qubit according to a quantum state of the first qubit when executing a two-qubit gating.
G06N 10/40 - Réalisations ou architectures physiques de processeurs ou de composants quantiques pour la manipulation de qubits, p. ex. couplage ou commande de qubit
80.
DECODING DEVICE, DECODING METHOD, PROGRAM, AND QUANTUM COMPUTER
A decoding device 1 decodes measurement results of a concatenated quantum code in which a plurality of quantum codes are concatenated, the decoding device including: a level 1 minimum distance candidate calculation unit 11 that, when the number of concatenated quantum codes is L, obtains a minimum distance, which is the minimum value of the Hamming distance between a code word and a measurement result, for each level 1 code block, and selects an encoded bit string corresponding to the minimum distance of each level 1 code block as a minimum distance candidate for each level 1 code block; a level i minimum distance candidate calculation unit 14 that, for i = 2,..., L, obtains the minimum distance for each level i code block by using a level (i-1) minimum distance and minimum distance candidate, for each level i encoded block consisting of a plurality of level (i-1) encoded blocks, and selects an encoded bit string corresponding to the minimum distance of each level i code block as a minimum distance candidate for each level i code block; and an output unit 20 that selects and outputs one of the level L minimum distance candidates.
H03M 13/19 - Correction d'une seule erreur sans utiliser les propriétés particulières des codes cycliques, p. ex. codes de Hamming, codes de Hamming étendus ou généralisés
G06N 10/70 - Correction, détection ou prévention d’erreur quantique, p. ex. codes de surface ou distillation d’état magique
1−xx2212−y−δyδ2222. X is at least one element selected from the group consisting of Cr, Sb, In, and V. The relationship 0 ≤ x ≤ 1 is satisfied. The relationships 0 < y ≤ 2 and 0 ≤ δ ≤ 1, or 0 ≤ y ≤ 2 and 0 < δ ≤ 1, are satisfied. The film has a film thickness of at least 1.0 nm and less than 70 μm.
This method for producing mesenchymal cells of the ventral hindgut mesoderm comprises: culturing pluripotent stem cells in an induction medium A containing a TGF-β inhibitor, a Wnt agonist, and a fibroblast growth factor to induce differentiation into epiblast-like cells; culturing the epiblast-like cells in an induction medium B containing a Wnt agonist, a fibroblast growth factor, and retinoic acid to induce differentiation into caudal epiblast-like cells; culturing the caudal epiblast-like cells in an induction medium C containing a Wnt agonist, a bone morphogenetic protein, and a TGF-β family member to induce differentiation into posterior primitive streak cells; and culturing the posterior primitive streak cells in an induction medium D containing a Wnt agonist, a fibroblast growth factor, a bone morphogenetic protein, and a hedgehog signaling agonist to induce differentiation into mesenchymal cells of the ventral hindgut mesoderm.
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
83.
TRAVELLING-WAVE PARAMETRIC AMPLIFIER AND QUANTUM INFORMATION PROCESSING SYSTEM
There is provided a travelling-wave parametric amplifier including: a plurality of group cells each including a plurality of unit cells, wherein the plurality of unit cells include: a transmission line that extends along a predetermined direction; and non-linear inductance elements and shunt capacitors arranged along the transmission line, wherein a respective group cell of the plurality of group cells comprises a periodic structure in which the non-linear inductance elements and the shunt capacitors periodically change along the transmission line, and wherein the plurality of group cells comprise a modulation structure in which the non-linear inductance elements and the shunt capacitors modulate along the transmission line.
The present invention provides a catalyst-layer-equipped electrolyte membrane and an application of the same, said catalyst-layer-equipped electrolyte membrane comprising: an anode catalyst layer containing an ionomer and an anode catalyst component that is composed of iridium-containing manganese dioxide, the molar ratio of iridium to manganese in the anode catalyst component being 0.011-0.182, and the logarithm log(amount of ionomer/amount of anode catalyst component) of the ratio of the amount of the ionomer to the amount of the anode catalyst component being −1.40 to −0.46; a proton exchange membrane; and a cathode catalyst layer.
C25B 9/23 - Cellules comprenant des électrodes fixes de dimensions stablesAssemblages de leurs éléments de structure avec des diaphragmes comprenant des membranes échangeuses d'ions dans ou sur lesquelles est incrusté du matériau pour électrode
C25B 1/04 - Hydrogène ou oxygène par électrolyse de l'eau
C25B 9/00 - Cellules ou assemblages de cellulesÉléments de structure des cellulesAssemblages d'éléments de structure, p. ex. assemblages d'électrode-diaphragmeCaractéristiques des cellules relatives aux procédés
C25B 9/77 - Assemblages comprenant plusieurs cellules du type filtre-presse avec diaphragmes
C25B 11/052 - Électrodes comportant un substrat et un ou plusieurs revêtements électro-catalytiques
C25B 11/057 - Électrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau du substrat ou du support formé d’un seul élément ou composé
C25B 11/079 - Dioxyde de manganèseDioxyde de plomb
An object of the present invention is to provide a cell population suitable for transplant of retinal tissue and a method of production thereof. The present invention provides a cell population for transplant, comprising retinal cells with a modified bipolar cell-regulating gene and a method of production thereof.
In order to provide an IR-QCL element which utilizes the characteristics of a ZnO-based semiconductor material, the present disclosure discloses a quantum cascade laser element 1000 that has a plurality of unit structures 10U in each of which a well layer of ZnO or ZnMgO and a barrier layer of ZnMgO or MgO are alternately and repeatedly stacked. Each unit structure includes a light emitting layer 10E and a continuum layer 10C. The light emitting layer includes: an upstream well layer 10W1 that is composed of a step quantum well having a first layer and a second layer, which have different MgO composition ratios from each other; and a downstream well layer 10W2 that has a smaller MgO composition ratio than any of the first layer and the second layer.
H01S 5/347 - Structure ou forme de la région activeMatériaux pour la région active comprenant des structures à puits quantiques ou à superréseaux, p. ex. lasers à puits quantique unique [SQW], lasers à plusieurs puits quantiques [MQW] ou lasers à hétérostructure de confinement séparée ayant un indice progressif [GRINSCH] dans des composés AIIBVI, p. ex. laser ZnCdSe
87.
NON-TRANSITORY COMPUTER-READABLE RECORDING MEDIUM, INFORMATION PROCESSING APPARATUS, AND PREDICTION CONTROL METHOD
A non-transitory computer-readable recording medium has stored therein a prediction control program that causes a computer to execute a process. The prediction control program is a prediction control program of a structure prediction model that predicts a three-dimensional structure of an organic compound from sequence information on the organic compound. The process comprises changing an intermediate feature value of the structure prediction model so that a difference between first limiting information and second limiting information different from the first limiting information is lessened, the first limiting information corresponding to a predicted structure output as a prediction result from the structure prediction model.
G16B 15/00 - TIC spécialement adaptées à l’analyse de structures moléculaires bidimensionnelles ou tridimensionnelles, p. ex. relations structurelles ou fonctionnelles ou alignement de structures
G16B 40/00 - TIC spécialement adaptées aux biostatistiquesTIC spécialement adaptées à l’apprentissage automatique ou à l’exploration de données liées à la bio-informatique, p. ex. extraction de connaissances ou détection de motifs
Provided are: a novel stem cell activator; a topical skin preparation containing the stem cell activator; and a skin cosmetic containing the stem cell activator. The stem cell activator according to the present invention contains, as an active ingredient, at least one compound selected from compounds represented by the following formula (1) (including optical isomers), salts of these compounds, and hydrates thereof. In the formula, R1and R2represent a hydrogen atom or a hydrocarbon group. R3 represents a hydrogen atom or an organic group. n represents an integer of 1 or more. The hydrocarbon group may be substituted.
A61K 31/662 - Acides du phosphore ou leurs esters ayant des liaisons P-C, p. ex. foscarnet, trichlorfon
A61K 8/55 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant du phosphore
A61P 17/00 - Médicaments pour le traitement des troubles dermatologiques
A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes
A61Q 19/00 - Préparations pour les soins de la peau
89.
SHEET-LIKE CELL CULTURE AND METHOD FOR PRODUCING SAME
To provide a method for producing a sheet-like cell culture showing a three-layer structure including a cell layer of superficial cells, a cell layer of intermediate cells, and a cell layer of basal cells, in this order. Provided is a method for producing a sheet-like cell culture that includes culturing a progenitor cell population in a second compartment separated from a first compartment via a porous member to form a sheet-like cell culture in the second compartment. The sheet-like cell culture includes a cell layer of superficial cells derived from the progenitor cell population, a cell layer of intermediate cells derived from the progenitor cell population, and a cell layer of basal cells derived from the progenitor cell population, in this order. The first compartment holds an induction medium containing retinoic acid, bone morphogenetic protein (BMP), and fibroblast growth factor (FGF).
C12N 5/071 - Cellules ou tissus de vertébrés, p. ex. cellules humaines ou tissus humains
A01K 67/0271 - Vertébrés chimériques, p. ex. comprenant des cellules exogènes
A61K 35/12 - Substances provenant de mammifèresCompositions comprenant des tissus ou des cellules non spécifiésCompositions comprenant des cellules souches non embryonnairesCellules génétiquement modifiées
A61L 27/36 - Matériaux pour prothèses ou pour revêtement de prothèses contenant des constituants de constitution indéterminée ou leurs produits réactionnels
A61L 27/40 - Matériaux composites, c.-à-d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent
A61P 13/10 - Médicaments pour le traitement des troubles du système urinaire de la vessie
C12Q 1/02 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des micro-organismes viables
90.
CONCENTRATION DIFFERENCE POWER GENERATION SYSTEM, POWER GENERATION METHOD, AND METAMATERIAL ABSORBER
Provided is a concentration difference power generation system 100 which utilizes a concentration difference liquid including a first liquid 22 and a second liquid 42 having a concentration lower than that of the first liquid, in order to provide renewable energy power generation which utilizes sunlight and easily adapts power generation amount to demand. The first liquid is in contact with a metamaterial absorber 10. Upon irradiation with sunlight, the metamaterial absorber accelerates evaporation of a solvent from the first liquid in accordance with energy from the sunlight, and increases the concentration of the solute of the first liquid. The concentration difference power generation system additionally comprises, as needed: a first liquid storage unit 30 and an evaporation pool 20 for the first liquid 22; a second liquid storage unit 40 for supplying the second liquid 42; and a concentration difference power generation unit 50.
The present invention facilitates catalyst designing. A catalyst design system according to one embodiment of the present invention is a system for designing a catalyst that promotes a specific chemical reaction, and comprises: an acquisition unit that acquires information for identifying a chemical reaction that is specified by a user and that is to be promoted by the catalyst; an extraction unit that extracts, from a database, information pertaining to a molecular structure included in the chemical reaction identified on the basis of the acquired information, and a state quantity in the process of the chemical reaction; a learning unit that performs machine learning using the information pertaining to the molecular structure and the state quantity that have been extracted from the database, to generate a prediction model; a prediction unit that uses the prediction model to predict a state quantity from the information pertaining to the molecular structure specified by the user; and an identification unit that identifies a dominant factor of the predicted state quantity and displays the dominant factor.
G16C 20/10 - Analyse ou conception des réactions, des synthèses ou des procédés chimiques
G16C 20/70 - Apprentissage automatique, exploration de données ou chimiométrie
92.
DEVICE FOR ENSURING RELIABILITY OF SERVICE BY DATA SCIENCE, METHOD FOR ENSURING RELIABILITY OF SERVICE BY DATA SCIENCE, AND COMPUTER PROGRAM FOR CAUSING COMPUTER TO EXECUTE SAID METHOD
Provided is a device for ensuring the reliability of a service by data science, the device comprising: an acquisition unit that, for each of a plurality of deviations considered to be likely to occur in a service, acquires grounds information indicating a plurality of grounds for resolving each deviation, the grounds information being agreed upon between a plurality of stakeholders who exchange the service; a generation unit that determines a plurality of first relationships between the plurality of grounds and mutually associates the plurality of grounds on the basis of the plurality of first relationships, thereby generating self-describing information units in which each deviation is accounted for; and a calculation unit that determines a plurality of second relationships between the plurality of self-describing information units generated for each of the plurality of deviations, calculates a feature amount for each of the plurality of self-describing information units, and mutually associates the plurality of feature amounts on the basis of the plurality of second relationships, thereby calculating a reliability feature amount representing the reliability of the service.
MOVING IMAGE PROCESSING DEVICE FOR PROVIDING MOVING IMAGE INDICATING BEAT OF MUSICAL PIECE, MOVING IMAGE PROCESSING METHOD, PROGRAM, AND INFORMATION RECORDING MEDIUM
A moving image processing device (101) provides a moving image indicating the beat of a musical piece being reproduced. A setting unit (102) sets a vicinity position in the vicinity of a predetermined position in a screen. An input unit (103) receives an input of a beat moving image reproduced in synchronization with the musical piece which is reproduced in accordance with a control signal output from a DJ controller. The beat moving image is a moving image in which a beat object associated with each beat of the musical piece moves in the screen, and the beat object associated with the relevant beat reaches the predetermined position in the screen at a beat timing at which the relevant beat of the musical piece is reproduced. Each time a frame of the beat moving image is input, a drawing unit (104) draws a timing object at the set vicinity position in the input frame. An output unit (105) outputs a frame in which the timing object is drawn as a frame of a timing moving image. If a detection unit (106), which may be omitted, detects a scratch operation, the drawing unit (104) also draws a scratch object.
The invention aims to provide a medicament having a superior anti-malignant tumor effect and a method for treating a malignant tumor therewith. In particular, the medicament contains a bacterium and a liposome encapsulating an anti-malignant tumor agent in combination.
A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique
A61K 31/475 - QuinoléinesIsoquinoléines ayant un cycle indole, p. ex. yohimbine, réserpine, strychnine, vinblastine
A61K 31/704 - Composés ayant des radicaux saccharide liés à des composés non-saccharide par des liaisons glycosidiques liés à un composé carbocyclique, p. ex. phloridzine liés à un système carbocyclique condensé, p. ex. sennosides, thiocolchicosides, escine, daunorubicine, digitoxine
According to an aspect, a fluorescence detection device includes: a light source configured to irradiate a sample with excitation light in a circularly polarized state; a sample holder configured to hold the sample; a cholesteric liquid crystal layer configured to transmit fluorescence emitted by the sample due to the excitation light and reflect the excitation light; and a sensor configured to detect the fluorescence transmitted through the cholesteric liquid crystal layer.
The present invention addresses the problem of providing a tough, fluorescent self-repairing elastomer. The present invention provides a copolymer having a first unit and a second unit that are at least two different types of olefin-derived repeating units, and a third unit that is at least one type of compound-derived repeating unit having at least one type of light-emitting unit in a side chain.
C08F 210/00 - Copolymères d'hydrocarbures aliphatiques non saturés contenant une seule liaison double carbone-carbone
C08F 212/00 - Copolymères de composés contenant un ou plusieurs radicaux aliphatiques non saturés, chaque radical ne contenant qu'une seule liaison double carbone-carbone et l'un au moins étant terminé par un noyau carbocyclique aromatique
C08F 212/14 - Monomères contenant un seul radical aliphatique non saturé contenant un cycle substitué par des hétéro-atomes ou des groupes contenant des hétéro-atomes
ATOM TRAP DEVICE, ATOM COOLING DEVICE, SPECTROSCOPIC DEVICE, OPTICAL LATTICE CLOCK, QUANTUM COMPUTER, COIL, ATOM TRAP METHOD, ATOM COOLING METHOD, AND SPECTROSCOPIC METHOD
This atom trap device 10 for trapping atoms comprises an atom trap unit 16 on which an atomic gas beam is incident. The atom trap unit 16 includes a plurality of optical elements that form a laser light group 18, and a magnetic field generation unit 22. The magnetic field generation unit 22 is provided with at least two spiral coils and, if necessary, a tapered solenoid coil, and optimizes a magnetic field in a guide direction. The spiral coils are configured so that the tip becomes thinner and the winding density becomes sparse as the atoms advance in the direction in which the atoms are guided. The spiral coils are arranged so as to face each other so that an interval therebetween becomes narrower as the atoms advance in the direction in which the atoms are guided. The tapered solenoid coil generates a magnetic field that optimizes the guiding of the atoms and the laser cooling during the guiding by adjusting the component in the direction in which the atoms of the magnetic field generated by the spiral coils are guided. The atom trap unit 16 may also include a baseball coil instead of the spiral coils and the tapered solenoid coil.
The purpose of the present invention is to provide a novel prophylactic and/or therapeutic agent for a neurodegenerative disease, which can increase the number of new neurons in an adult brain. The present invention is a prophylactic and/or therapeutic agent for a neurodegenerative disease, the agent containing, as an active ingredient, an inhibitor of any one of genes shown in table 1 or a protein derived from any one of the genes.
A61K 45/00 - Préparations médicinales contenant des ingrédients actifs non prévus dans les groupes
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
The present invention relates to: a catalyst precursor for ammonia synthesis, the catalyst precursor including a nitrogen activation catalyst precursor loaded body (A1) in which a precursor of a catalyst component for activating nitrogen is supported by a carrier that is composed of a porous body that has a specific surface area of 1,000 m2/g or more, and a hydrogen activation catalyst precursor loaded body (B1) in which a precursor of a catalyst component for activating hydrogen is supported by a carrier that is different from the above-described carrier; and a catalyst for ammonia synthesis obtained by activating the catalyst precursor.
B01J 35/73 - Catalyseurs caractérisés par leur forme ou leurs propriétés physiques, en général caractérisés par leurs propriétés cristallines, p. ex. semi-cristallines ayant une structure cristalline bidimensionnelle stratifiée, p. ex. hydroxydes doubles lamellaires [HDL]
B01J 37/02 - Imprégnation, revêtement ou précipitation
Provided is a fabrication method for an electric circuit device, the fabrication method including forming a conductive layer on a substrate, forming a bottom resist layer on the conductive layer, forming a cover layer on the bottom resist layer, forming a top resist layer on the cover layer, forming a contact hole in the substrate by using the top resist layer as a mask, forming a first undercut structure by etching the bottom resist layer below the cover layer, and forming a contact metal layer on a sidewall of the contact hole and above a front surface of the substrate after the first undercut structure is formed.
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