A method and computer-based system is provided that assists physicians in detecting early tumor growth, for example, glioblastoma (GMB) and low-grade gliomas, and allowing modification of treatment to have a positive impact on medical management, patient morbidity, outcomes and survival times. The method comprises measuring tumor volumes from radiological images to predict growth by a statistical method. The methods allow detection of increases in tumor size earlier than is currently possible and, therefore, advantageous in modifying or optimizing treatment.
A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
2.
NERVE STIMULATION DEVICE FOR CHRONIC PAIN MANAGEMENT
A nerve stimulation device for delivering pain management electrical pulses to nerves includes a flexible substrate that is skin-mountable or implantable. An implantable lead includes microelectrodes provided with a coating for improving charge delivery via a porous electrode structure, and/or to reduce infection risk. In one embodiment, a flexible-substrate wearable energy transmitter patch transmits a power signal wirelessly (e.g., via induction coils) through the skin to an implanted flexible-substrate stimulator component that receives the power signal, generates a tonic signal for pain mitigation, and delivers the tonic signal to nerve stimulation points adjacent the electrodes of an implanted lead. In another embodiment, a flexible-substrate stimulator includes a power source and pulse generator, and the tonic signal is transmitted wirelessly through the skin to an implanted lead having electrodes for delivering the pulses to the stimulation points. Accordingly, the device can be worn without skin perforation, which reduces infection risk.
Disclosed is an ionizable lipid nanoparticle (LNP) composition having four lipid components: C12-200, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE), cholesterol, and (1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)) (DMPE-PEG). The LNP composition is useful for delivering RNA to the placenta, thus also providing methods of treating placenta-related disorders.
A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
A61P 15/00 - Drugs for genital or sexual disordersContraceptives
A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
A method for introduction of a sample into a liquid chromatography column with improved speed and reduced time between injections can utilize a segmented sample array that segments samples between segmenting fluid plugs to allow for substantially simultaneous injection of samples from an injection valve and preparation for next sample loading into the injection valve.
The present disclosure relates to antibacterial hydrogel compositions comprising a synergistic combination of antimicrobial peptides, and methods and kits for preparing the same.
C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving viable microorganisms
C07K 14/31 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
The present disclosure provides a system and method for producing nanofibers. The system includes an automated track system including a first track having a first face; and a second track having a second face facing the first face of the first track. The first track and the second track are positioned to define a proximal gap and a distal gap. The first track and the second track are adapted and configured to transfer a nanofiber coupled to the first face and the second face from the proximal gap to the distal gap. The system also includes a roving belt that is positioned to be partially disposed within the distal gap and is adapted and configured to decouple the nanofiber from the first face and the second face.
Provided herein is a system for producing fibers. The system includes a centrifugal spinning apparatus including a centrifugal spinning device configured to produce one or more fibers in a radial direction; a fiber collection apparatus including a collection element positioned relative to the centrifugal spinning apparatus and a collection surface on the collection element, wherein the collection surface is arranged and disposed to contact the one or more fibers produced by the centrifugal spinning apparatus; and a drive mechanism configured to move at least a portion of at least one of the centrifugal spinning apparatus and the fiber collection apparatus in a transverse direction with respect to the other. Also provided herein is a method of producing fibers using the system.
Methods of detecting cysteine-containing peptides are provided. The methods include steps of contacting a resistive-pulse nanopore sensing system with a sample containing cysteine-containing peptides of at least 10 amino acid residues in length, wherein the resistive-pulse nanopore sensing system comprises thiolate-capped gold clusters arranged in a cis side of nanopores and detecting a change in current indicative of exchange between a cysteine-containing peptide and the thiolate-capped gold clusters.
A device for orienting bone fragments is provided herein. The device includes a support element, at least three positional markers disposed on the support element, and at least three optical tracking markers disposed on the support element. Also provided herein are a system including the device and a method of monitoring bone fragment positioning in real-time using the device.
A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61B 17/56 - Surgical instruments or methods for treatment of bones or jointsDevices specially adapted therefor
12.
MULTI-SESSION SUPPORT SYSTEM FOR HEALTHCARE PROFESSIONALS
A multi-session support system for caregivers that enables quick and easy data collection in a first (notetaking) computing session, synchronously with the delivery of care to multiple patients in a multi-patient care session. Further, the system allows the informal care information notation records developed in the first computing session (e.g., on a mobile phone during a work shift) to be reviewed, edited, augmented, etc. in a second (formal care documentation record creation) computing session, which may be conducted at a later time on a different computing platform (e.g., on a desktop computer after the end of a work shift). Accordingly, the present invention helps to reduce the care documentation burden, by allowing caregivers to take short notes synchronously with the delivery of care, and to prepare formal documentation based on the notes asynchronously with the delivery of care, so that neither patient care nor care documentation are compromised.
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
13.
MULTI-SESSION SUPPORT SYSTEM FOR HEALTHCARE PROFESSIONALS
A multi-session support system for caregivers that enables quick and easy data collection in a first (notetaking) computing session, synchronously with the delivery of care to multiple patients in a multi-patient care session. Further, the system allows the informal care information notation records developed in the first computing session (e.g., on a mobile phone during a work shift) to be reviewed, edited, augmented, etc. in a second (formal care documentation record creation) computing session, which may be conducted at a later time on a different computing platform (e.g., on a desktop computer after the end of a work shift). Accordingly, the present invention helps to reduce the care documentation burden, by allowing caregivers to take short notes synchronously with the delivery of care, and to prepare formal documentation based on the notes asynchronously with the delivery of care, so that neither patient care nor care documentation are compromised.
G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 80/00 - ICT specially adapted for facilitating communication between medical practitioners or patients, e.g. for collaborative diagnosis, therapy or health monitoring
14.
COMPOSITIONS AND METHODS FOR CELL CULTURE APPLICATIONS
The present disclosure generally relates methods and compositions comprising thermosensitive hydrogel compositions that can be used for embedded patterning of cells, cell aggregates, or organoids. The present disclosure further generally relates to methods of inducing cell condensation into geometrically directed tissue structures and simultaneously producing therapeutic cell secretomes.
An environmentally-friendly approach to producing concrete using reclaimed concrete aggregate material is provided. Reclaimed concrete aggregate material is obtained by processing recycled concrete aggregate (RCA) waste materials with an impact treatment. The RCA contains natural stone or other aggregate particles that has cementitious material bonded thereto. The impact treatment removes at least a portion of the cementitious material from the aggregate particles, leaving reclaimed concrete aggregate particles having sufficiently little bonded cementitious material so as to be a suitable alternative to virgin aggregate in asphalt and concrete mixes, even for concrete that will be used in structural load-bearing applications for use to construct structural members of buildings and other structures. The impact treatment may be performed by tumbling RCA with impactors in a rotating drum.
Carbon sequestering infrastructure incorporates carbon-sequestering cladding members that are separate and distinct from structural elements configured to carry a structural load of the infrastructure. The cladding is capable of capturing and sequestering carbon from carbon dioxide in atmospheric/ambient air. The cladding may be distinct members having a high carbon capture capacity (but a low compressive strength unsuitable for use in a structural member) attached to structural members having a lower carbon capture capacity (and a higher compressive strength suitable for use in a structural member). The cladding member may be formed as an envelope suitable for use as a form in casting a structural member. Infrastructure elements including cladding may be configured such that the cladding is removable and replaceable after is carbon sequestering capacity is diminished, to allow for carbon sequestration over the entire length of the infrastructure.
Carbon sequestering infrastructure incorporates carbon-sequestering cladding members that are separate and distinct from structural elements configured to carry a structural load of the infrastructure. The cladding is capable of capturing and sequestering carbon from carbon dioxide in atmospheric/ambient air. The cladding may be distinct members having a high carbon capture capacity (but a low compressive strength unsuitable for use in a structural member) attached to structural members having a lower carbon capture capacity (and a higher compressive strength suitable for use in a structural member). The cladding member may be formed as an envelope suitable for use as a form in casting a structural member. Infrastructure elements including cladding may be configured such that the cladding is removable and replaceable after is carbon sequestering capacity is diminished, to allow for carbon sequestration over the entire length of the infrastructure.
E04F 13/14 - Coverings or linings, e.g. for walls or ceilings composed of covering or lining elementsSub-structures thereforFastening means therefor composed of a plurality of similar covering or lining elements of stone or stone-like materials, e.g. ceramicsCoverings or linings, e.g. for walls or ceilings composed of covering or lining elementsSub-structures thereforFastening means therefor composed of a plurality of similar covering or lining elements of glass
An environmentally friendly approach to producing concrete using reclaimed concrete aggregate material is provided. Reclaimed concrete aggregate material is obtained by processing recycled concrete aggregate (RCA) waste materials with an impact treatment. The RCA contains natural stone or other aggregate particles that has cementitious material bonded thereto. The impact treatment removes at least a portion of the cementitious material from the aggregate particles, leaving reclaimed concrete aggregate particles having sufficiently little bonded cementitious material so as to be a suitable alternative to virgin aggregate in asphalt and concrete mixes, even for concrete that will be used in structural load-bearing applications for use to construct structural members of buildings and other structures. The impact treatment may be performed by tumbling RCA with impactors in a rotating drum.
B02C 23/10 - Separating or sorting of material, associated with crushing or disintegrating with separator arranged in discharge path of crushing or disintegrating zone
G01N 21/3563 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing solidsPreparation of samples therefor
G01N 21/3581 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using far infrared lightInvestigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using Terahertz radiation
21.
DEVICE FOR TESTING VAPORIZABLE FLUIDS IN A HUMAN AIRWAY MODEL
A testing device for testing the impact of aerosolized compounds, such as e-cigarette vapors, metered-dose inhaled corticosteroids, and nebulized medications, on a human airway model system/tissue for purposes related to basic and clinical research, diagnostics, and personalized medicine. The device includes an intake fan assembly, a housing defining an exposure chamber, a holder supported on said housing for supporting an aerosol-generating device; and a control system operable to selectively energize the intake fan to draw the aerosolized compound into the exposure chamber, where human tissue is disposed. The testing device may also include an actuator operable by the control system to cause the aerosol-generating device to generate the aerosolized compound. The testing device may also include an exhaust fan operable by the control system to exhaust the aerosolized compound from the exposure chamber. Testing device components may be constructed of a biocompatible material that is autoclavable without detrimental degradation.
The present disclosure provides methods of controlling the size of cellulose crystals by mixing a first composition comprising cellulose and coagulating this mixture with varying concentrations of hydrogen peroxide.
A room air monitoring device for exposing human airway model system/tissue or other media to ambient air for air quality monitoring purposes. The device includes a housing defining an exposure chamber, and a chamber cap defining an opening for admitting air into the exposure chamber. The device also includes an intake fan operable to draw ambient air through the chamber cap, into the exposure chamber, and out of the exposure chamber. A temperature maintaining system can heat an interior of the exposure chamber to a temperature approximating a human body tissue temperature. A control system maintains a temperature of the exposure chamber within a desired temperature range, and may selectively energize the electric motor to draw ambient air into the exposure chamber. The testing device components may be constructed of a biocompatible material that is autoclavable without detrimental degradation.
One aspect of the present disclosure provides for a computer-implemented method for automated detection of cognitive conditions as described herein (e.g., to detect emergent neurocognitive decline consistent with mild cognitive impairment (MCI) and Alzheimer's Disease and Related Dementias (ADRD)).
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
One aspect of the present disclosure provides for a computer-implemented method for automated detection of cognitive conditions as described herein (e.g., to detect emergent neurocognitive decline consistent with mild cognitive impairment (MCI) and Alzheimer's Disease and Related Dementias (ADRD)).
A61B 5/16 - Devices for psychotechnicsTesting reaction times
A61B 3/032 - Devices for presenting test symbols or characters, e.g. test chart projectors
G16H 20/70 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mental therapies, e.g. psychological therapy or autogenous training
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
27.
METHODS AND APPARATUS FOR DETECTING ABNORMAL TISSUE AND OTHER FOREIGN MATTER IN A BODY
BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY (USA)
Inventor
Moghimi, S. Mohammad J.
Abstract
This disclosure pertains to methods, apparatus, systems, and techniques for non-invasively detecting abnormal biological tissue and other abnormal matter in a body.
A61B 3/00 - Apparatus for testing the eyesInstruments for examining the eyes
H05K 1/16 - Printed circuits incorporating printed electric components, e.g. printed resistor, capacitor, inductor
A61B 3/16 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for measuring intraocular pressure, e.g. tonometers
An acoustic filter mitigates audio signal-based attacks (particularly inaudible attacks in the ultrasonic frequency range) on voice-based computing devices by modulating the signals before they reach the device's microphone. One filter is formed as a rigid body defining multiple holes that exhibit local resonance phenomena that suppress incoming audio waves at specific frequencies. The filter distorts or otherwise modifies the attack signals and thereby prevents the microphone(s) from receiving the intended attack signal, and prevents the associated computing device from processing and executing the intended malicious "command"/signal. The filter can be tuned to be operable outside the frequency range of normal spoken commands, so that typical voice-based commands are unaffected by the filter. A frame is provided to enable one or more filters to be retrofitted to existing consumer electronics devices, outside their housings. Alternatively, new consumer electronics may be manufactured to include such filters inside their housings.
H04R 1/28 - Transducer mountings or enclosures designed for specific frequency responseTransducer enclosures modified by provision of mechanical or acoustic impedances, e.g. resonator, damping means
G10K 11/178 - Methods or devices for protecting against, or for damping, noise or other acoustic waves in general using interference effectsMasking sound by electro-acoustically regenerating the original acoustic waves in anti-phase
29.
ABSORBANCE-COUPLED VOLTAGE CONTROL OF ELECTROSPRAY IONIZATION
Provided herein is a system for applying voltage in electrospray ionization. The system includes an electrospray nozzle arrangement, the electrospray nozzle arrangement including an electrospray nozzle; an in-line absorbance detector; a high voltage power supply electrically coupled to the electrospray nozzle; and a computer-controlled system configured to apply voltage from the high voltage power supply to the electrospray nozzle based upon readings from the in-line absorbance detector. Also provided herein is a method for applying voltage in electrospray ionization using an in-line absorbance detector.
In one aspect, the present disclosure is related to system and method of manufacturing nanomaterials and particularly to system and method for zone-drawing and/or zone-annealing fibers.
D01F 9/22 - Carbon filamentsApparatus specially adapted for the manufacture thereof by decomposition of organic filaments from polyaddition, polycondensation or polymerisation products from macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds from polyacrylonitriles
31.
METHOD FOR RECYCLING CEMENT-CONTAINING MATERIALS TO PRODUCE RECLAIMED FINES FOR USE IN CEMENT-BASED MATERIALS AND STRUCTURES
An environmentally-friendly substitute for virgin dry cement is provided. The substitute is obtained as reclaimed cementitious fines produced by recycling cement-containing waste materials, such as recycled concrete aggregate and demolished brick structures. The reclaimed cementitious fines are used as cementitious material in new concrete, mortar, cement paste and other cement-containing materials and structures. A recycling method involves obtaining cement-containing waste material, crushing the cement-containing waste material, gathering the crushed cement-containing waste materials, the crushed cement-containing waste materials comprising reclaimed particles derived from said cement-containing waste material; and sorting the crushed cement-containing waste materials by particle size to obtain reclaimed cementitious fines having sizes in a desired particle size range, e.g., 0.1 micron to 200 micron for use as a substitute for virgin dry cement powder. Notably, the crushing/tumbling methodologies used to obtain the reclaimed particles produce significantly less carbon dioxide that the methodologies used to obtain virgin dry cement.
36 - Financial, insurance and real estate services
Goods & Services
Charitable fundraising services, namely conducting fundraising campaigns for the purpose of raising funds to support university academic programs, athletics, scholarships, and facilities
33.
THREE-DIMENSIONAL PRINTABLE BIOCOMPATIBLE PHOTOPOLYMERIZABLE INK WITH SPATIALLY CONTROLLED DUAL PROTEIN MOTIFS FOR CO-CULTURE FUNCTIONALITY
A three-dimensional biocompatible photoink useful for three-dimensional printing includes a biocompatible polymer having at least one covalently bonded photoink. The biocompatible photoink can suitably include a photoinitiator, a photo-absorber and a crosslinker and, in some embodiments, may include live tissue cells and an RGD peptide protein.
A three-dimensional biocompatible photoink useful for three-dimensional printing includes a biocompatible polymer having at least one covalently bonded photoink. The biocompatible photoink can suitably include a photoinitiator, a photo-absorber and a crosslinker and, in some embodiments, may include live tissue cells and an RGD peptide protein.
C09D 11/101 - Inks specially adapted for printing processes involving curing by wave energy or particle radiation, e.g. with UV-curing following the printing
C09D 11/08 - Printing inks based on natural resins
C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules
C08F 2/46 - Polymerisation initiated by wave energy or particle radiation
C08L 81/00 - Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing sulfur with or without nitrogen, oxygen, or carbon onlyCompositions of polysulfonesCompositions of derivatives of such polymers
B29C 64/00 - Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
pdcRFcc; coherently transferring the symmetrical RF sidebands to the first beam via a nonlinear wave mixing in the vapor cell; and determining an electromagnetic field inside the vapor cell.
H01S 3/0941 - Processes or apparatus for excitation, e.g. pumping using optical pumping by coherent light of a semiconductor laser, e.g. of a laser diode
G01N 21/63 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
36.
METHODS OF PRECISE GENOME EDITING BY IN SITU CUT AND PASTE (ICAP)
The present invention relates to innovative means of DNA sequence editing involving in-situ cut-and-paste (iCAP) or alternatively cut-and-paste in-situ (CAPi). Thus, in various embodiments described herein, the methods of the invention relate to methods of generating paired-end nucleic acid fragment sharing common linker nucleic acid sequences using a nicking endonuclease, a T7 endonuclease, a restriction enzyme or a transposase, methods of analyzing the nucleotides sequences from the linked-paired-end sequenced fragments and methods of de novo whole genome mapping.
The present disclosure relates to a multi-layer composite comprising at least a first sheet and a second sheet of aligned nanofibers coated with a biodegradable hydrogel, wherein the at least first and second sheets of aligned coated nanofibers are stacked directly on top of each other and a portion of the biodegradable hydrogel coating on the first sheet is mixed and crosslinked with a portion of the biodegradable hydrogel coating on the second sheet. In another aspect, the present disclosure relates to a method of regenerating an aligned soft tissue in a subject, the method comprising surgically implanting a synthetic tissue graft comprising the multi-layer composite in the subject at a site of missing or injured tissue. In yet another aspect, the present disclosure relates to a synthetic nerve graft comprising the multi-layer composite.
A61L 27/48 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
A61L 27/18 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
Described herein is a hydrogel including a hydrogel polymer; a crosslinker crosslinking the hydrogel polymer; a biomolecule attached to the hydrogel polymer; and water. In the hydrogel, the biomolecule is attached to the hydrogel polymer through an acrylic linker attached to a hydroxyl group in the hydrogel polymer. Also described is a hyaluronic acid (HA)-based hydrogel including a first HA polymer comprising a first crosslinker; a second HA polymer comprising a second crosslinker; a biomolecule attached to the first HA polymer or the second HA polymer through an acrylic linker attached to a hydroxyl group in the first HA polymer or the second HA polymer; and water. Also described is a method of producing the HA-based hydrogel, as well as a method of regenerating tissues using the hydrogels.
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
A61L 27/18 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
The present disclosure relates in part to methods of treating, preventing, and/or ameliorating SARS-CoV-2 infection and/or related inflammatory syndromes by administration of a Maackia amurensis seed lectin (MASL). MASL has a strong affinity for sialic acid modified proteins and may be used as an antiviral agent. This lectin targets the ACE2 receptor, decreases ACE2 expression and glycosylation, suppresses binding of the SARS-CoV-2 spike protein, and decreases expression of inflammatory mediators by oral epithelial cells that cause ARDS in COVID-19 patients.
A room air monitoring device for exposing human airway model system/tissue or other media to ambient air for air quality monitoring purposes. The device includes a housing defining an exposure chamber, and a chamber cap defining an opening for admitting air into the exposure chamber. The device also includes an intake fan operable to draw ambient air through the chamber cap, into the exposure chamber, and out of the exposure chamber. A temperature maintaining system can heat an interior of the exposure chamber to a temperature approximating a human body tissue temperature. A control system maintains a temperature of the exposure chamber within a desired temperature range, and may selectively energize the electric motor to draw ambient air into the exposure chamber. The testing device components may be constructed of a biocompatible material that is autoclavable without detrimental degradation.
A testing device for testing the impact of aerosolized compounds, such as e-cigarette vapors, metered-dose inhaled corticosteroids, and nebulized medications, on a human airway model system/tissue for purposes related to basic and clinical research, diagnostics, and personalized medicine. The device includes an intake fan assembly, a housing defining an exposure chamber, a holder supported on said housing for supporting an aerosol-generating device; and a control system operable to selectively energize the intake fan to draw the aerosolized compound into the exposure chamber, where human tissue is disposed. The testing device may also include an actuator operable by the control system to cause the aerosol-generating device to generate the aerosolized compound. The testing device may also include an exhaust fan operable by the control system to exhaust the aerosolized compound from the exposure chamber. Testing device components may be constructed of a biocompatible material that is autoclavable without detrimental degradation.
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
Described herein is a biocompatible injectable dosimeter. The injectable dosimeter comprises a polymer gel and a radiation dosimeter material distributed in the polymer gel. The dosimeter material in the injectable dosimeter, when radiated, generates a dosimetric signal, which can be used to evaluate the delivery of the radiation. Also described are methods of using the injectable dosimeter, such as to report radiation in real-time and to protect tissues adjacent to the disease sites being irradiated.
A multi-material printer for using multiple materials, e.g., bioinks, to quickly fabricate structures, such as high-throughput screening microfluidic chips. The printer's light projector for emits light in an exposure sequence to cure material in an additive manufacturing process. The printer further includes a motion stage operable to move a build platform into and out of the reservoir in coordination with the exposure sequence. The printer further includes an indexing stage having a work table for supporting the reservoir. The indexing stage is operable to selectively align the build platform with multiple different materials of the reservoir. The multiple materials may be arranged at distinct angular positions within a single reservoir, and the indexing stage may be operable to rotate the work table to align the build platform with different materials during the exposure sequence for a quick transition among different materials without refilling of materials, exchange of reservoirs, etc.
B29C 64/124 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified
A device for detecting an approaching train at a roadway railway crossing and providing an intervention for avoiding a collision that avoids the need for crossing site approval, installations, etc. and associated hardware and installation costs. The device may be configured as a stand-alone device, as an accessory matable to a motor vehicle (e.g., via an OBD II port), or may be fully integrated into the motor vehicle. The device includes a microphone for receiving an ambient audio signal, and processes the audio signal to determine whether a train is present. If so, the device may provide an audible and/or visual warning signal to a vehicle driver, via the device itself or via components of the motor vehicle. In certain other embodiments, the device is configured to provide a control signal causing operation of braking, engine, steering or other vehicle systems to avoid a collision.
A nerve stimulation device for delivering pain management electrical pulses to nerves includes a flexible substrate that is skin-mountable or implantable. An implantable lead includes microelectrodes provided with a coating for improving charge delivery via a porous electrode structure, and/or to reduce infection risk. In one embodiment, a flexible-substrate wearable energy transmitter patch transmits a power signal wirelessly (e.g., via induction coils) through the skin to an implanted flexible-substrate stimulator component that receives the power signal, generates a tonic signal for pain mitigation, and delivers the tonic signal to nerve stimulation points adjacent the electrodes of an implanted lead. In another embodiment, a flexible-substrate stimulator includes a power source and pulse generator, and the tonic signal is transmitted wirelessly through the skin to an implanted lead having electrodes for delivering the pulses to the stimulation points. Accordingly, the device can be worn without skin perforation, which reduces infection risk.
41 - Education, entertainment, sporting and cultural services
Goods & Services
Museum services, namely, providing museum services in the fields of dinosaurs and fossils; educational and entertainment services, namely, providing museum attractions in the nature of multimedia displays and exhibits in the fields of dinosaurs and fossils
The present disclosure provides a system and method for producing nanofibers. The system includes an automated track system including a first track having a first face; and a second track having a second face facing the first face of the first track. The first track and the second track are positioned to define a proximal gap and a distal gap. The first track and the second track are adapted and configured to transfer a nanofiber coupled to the first face and the second face from the proximal gap to the distal gap. The system also includes a roving belt that is positioned to be partially disposed within the distal gap and is adapted and configured to decouple the nanofiber from the first face and the second face.
Systems and methods for detecting aortic aneurysms using ensemble based deep learning techniques that utilize numerous computed tomography (CT) scans collected from numerous de-identified patients in a database. The system includes software that automates the analysis of a series of CT scans as input (in DICOM file format) and provides output in two dimensions: (1) ranking CT scans by risks of adverse events from aortic aneurysm, (2) providing aortic aneurysm size estimates. A repository of CT scans may be used for training of deep neural networks and additional data may be drawn from localized patient information from institutions and hospitals which grant permission.
A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
In one aspect, the present invention relates to thermo-reversible hydrogel drug delivery compositions comprising at least one biodegradable copolymer drug carrier. In certain embodiments, the hydrogel compositions of the invention are optically clear and suitable for use in local delivery of ocular therapeutics. In other embodiments, the hydrogel compositions of the invention provide a means for controlled or sustained drug delivery.
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/573 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A61K 47/61 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
52.
NETWORK TOUGHENING OF ADDITIVELY MANUFACTURED, HIGH GLASS TRANSITION TEMPERATURE MATERIALS VIA SEQUENTIALLY CURED, INTERPENETRATING POLYMERS
The United States of America as Represented by the Secretary of the Army (USA)
Inventor
Bassett, Alexander W.
Stanzione, Iii, Joseph F.
La Scala, John J.
Abstract
Resins and formulations of individual monomers bearing both vinyl ester and epoxy functionality were either synthesized or formulated such that vinyl ester components capable of polymerizing by photo-induced, free radical polymerization were mixed with step-growth epoxy-amine systems, facilitating sequential cure. The vinyl ester component was photopolymerized using vat photopolymerization (VPP). Additionally, the preparation of bio-based photo curable thermosetting resins that have tailorable thermal and mechanical properties is provided. All monomers and polymers described herein are useful in a variety of applications, including additive manufacturing applications.
A computer product, including a logical environment system adapted to generate a logical network comprising a plurality of logically related, rule based junctions through which one or more entities traverse, a spatial environment system adapted to map one or more spatial constraints upon each logical relation between each of the one or more of the plurality of junction; and a rendering environment system adapted to move the one or more entities through the logical network subject to the corresponding spatial constraints and to visually display the results of the movement of the one or more entities via a graphical user interface.
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
54.
Training a neural network for a predictive aortic aneurysm detection system
Systems and methods for detecting aortic aneurysms using ensemble based deep learning techniques that utilize numerous computed tomography (CT) scans collected from numerous de-identified patients in a database. The system includes software that automates the analysis of a series of CT scans as input (in DICOM file format) and provides output in two dimensions: (1) ranking CT scans by risks of adverse events from aortic aneurysm, (2) providing aortic aneurysm size estimates. A repository of CT scans may be used for training of deep neural networks and additional data may be drawn from localized patient information from institutions and hospitals which grant permission.
G06V 10/22 - Image preprocessing by selection of a specific region containing or referencing a patternLocating or processing of specific regions to guide the detection or recognition
G06T 3/40 - Scaling of whole images or parts thereof, e.g. expanding or contracting
G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
The present invention relates generally to a device for providing multi-modal energy therapy to treat neurogenerative disorders, and more particularly to a device providing multi-modal neuro-supportive energy therapy to a person via a daily session in a single facility. The device provides safe, well studied energy therapies in a controlled manner to stimulate neuronal mitochondrial activity which powers the brains neurons and is often defective in neurodegenerative disease states. Selected energy delivery mechanisms and frequencies are employed to stabilize microglial activity and promote microglial homeostasis and neuroprotective secretions, including mitochondrial melatonin and other neuroprotective factors. In addition to practicality, the combination of these proven therapeutic modalities into a single device may offer synergies not found when they are employed alone. This focused combination of these unique energy based therapies may offer new hope to slow, stop, reverse or mitigate neurogenerative disorders, such as Alzheimer's, ALS and Parkinson's diseases.
A61H 23/02 - Percussion or vibration massage, e.g. using supersonic vibrationSuction-vibration massageMassage with moving diaphragms with electric or magnetic drive
57.
METHODS AND APPARATUSES FOR FORMING PATTERNED FIBER ARRAYS WITH AUTOMATED TRACKS
Methods for detecting Multiple Sclerosis (MS) diagnostic autoantibodies in a subject and generating a subject-specific, MS diagnostic autoantibody profile are described. The methods include contacting an immunoglobulin-containing biological sample from the subject with a system comprising antigens that form immunocomplexes with MS diagnostic autoantibodies, the antigens including general transcription factor II-I, splicing factor 1, and inducible T-cell co-stimulator (ICOS), to form a reaction mixture, under conditions that allow for formation in the reaction mixture of an immunocomplex between each antigen and its corresponding MS diagnostic autoantibody, if its corresponding MS diagnostic autoantibody is present in the sample; and detecting presence or absence of immunocomplexes in the reaction mixture, wherein formation of immunocomplexes between the antigens and their corresponding MS diagnostic autoantibodies indicates presence of the MS diagnostic autoantibodies in the biological sample.
Disclosed are methods, compositions and kits for detecting Multiple Sclerosis (MS) as well as for distinguishing relapsing-remitting (RRMS) and secondary progressive (SPMS) MS subtypes with high overall accuracy. Autoantibody antigens and biomarkers, for the diagnosis of MS in general, RRMS and SPMS, as well as for the identification of a subject at risk for developing MS, and for the generation of patient-specific MS autoantibody biomarker profiles are also provided.
The present disclosure relates to a multi-layer composite comprising at least a first sheet and a second sheet of aligned nanofibers coated with a biodegradable hydrogel, wherein the at least first and second sheets of aligned coated nanofibers are stacked directly on top of each other and a portion of the biodegradable hydrogel coating on the first sheet is mixed and crosslinked with a portion of the biodegradable hydrogel coating on the second sheet. In another aspect, the present disclosure relates to a method of regenerating an aligned soft tissue in a subject, the method comprising surgically implanting a synthetic tissue graft comprising the multi-layer composite in the subject at a site of missing or injured tissue. In yet another aspect, the present disclosure relates to a synthetic nerve graft comprising the multi-layer composite.
A61L 27/00 - Materials for prostheses or for coating prostheses
A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61K 35/12 - Materials from mammalsCompositions comprising non-specified tissues or cellsCompositions comprising non-embryonic stem cellsGenetically modified cells
A61L 27/50 - Materials characterised by their function or physical properties
62.
SYSTEMS AND METHODS FOR FIBER ZONE-DRAWING AND/OR ZONE-ANNEALING
In one aspect, the present disclosure is related to system and method of manufacturing nanomaterials and particularly to system and method for zone-drawing and/or zone-annealing fibers.
B01J 19/12 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor employing electromagnetic waves
63.
BEHAVIOR-BASED ACCESS CONTROL MANAGEMENT FOR APPLICATION SOFTWARE OF COMPUTING DEVICES
A computerized system and method providing a user interface for management of access to software applications and/or other computing device resources to achieve desired behavioral changes by using sensor-based hardware to assess behavioral aspects and selectively grant or deny desired access based on sensor-gathered data in comparison to predetermined behavior goals. In part, the present invention captures an opportunity to use access to desired mobile computing device apps (or other computing resources) as a low-cost, non-monetary incentive for beneficial behavior modification purposes, such as smoking cessation, etc.
The present invention provides a novel method of treatment for treating brain disorders that manifest oxidative stress by providing targeted populations of neurons with the ability to catabolize the acetylated amino acid derivative, N-acetylaspatic acid (NAA) and further supply extraphysiological levels of ATP to neurons via the targeted expression of the NAA catabolic enzyme aspartoacylase (ASPA) in neurons and astrocytes.
A method and computer-based system is provided that assists physicians in detecting early tumor growth and allowing modification of treatment to have a positive impact on medical management, patient morbidity, outcomes and survival times. The method comprises measuring tumor volumes from radiological images to predict growth by a statistical method. The methods allow detection of increases in tumor size earlier than is currently possible and, therefore, advantageous in modifying or optimizing treatment.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
66.
SYSTEM AND METHOD FOR THE EXTRACTION OF ISOFLAVONES FROM SOYBEANS
The present disclosure describes a system for the commercial scale extraction of isoflavones from soybean meal. The system includes an optional grinder, an extraction component, a solid-liquid separation component, an acid hydrolysis component, a neutralization component, and a purification component. Also provided are methods of commercial scale extraction of one or more isoflavones from soybean meal. The method includes extracting an isoflavone glucoside from soybean meal, hydrolyzing the isoflavone glucoside to obtain an isoflavone aglycone, neutralizing the isoflavone aglycone, and purifying the isoflavone aglycone.
A23C 11/02 - Milk substitutes, e.g. coffee whitener compositions containing at least one non-milk component as source of fats or proteins
A23C 11/10 - Milk substitutes, e.g. coffee whitener compositions containing at least one non-milk component as source of fats or proteins containing or not lactose but no other milk components as source of fats, carbohydrates or proteins
67.
HANDHELD PRINTER FOR ENHANCED MIXING AND DELIVERY OF MULTI-COMPONENT POLYMERS/BIOMATERIALS
A mixing injector for a multi-material printer. The injector defines coaxial passages for passing different material components into a mixing portion. The injector defines at least one opening, in a sidewall of at least one of the coaxial passages, to provide fluid communication between the passages, e.g., before/upstream from a mixing portion. Such openings permit and promote material component flow laterally, transversely to a direction of elongation of the coaxial passages, and transversely to a principal direction of flow of the material components. This is believed to create a degree of turbulence in the flow of the material components that enhances mixing of the material components, and provides for enhanced mixing of the component materials. Accordingly, for example, cross-linking may begin to occur before entering the mixing region. The injector may be structured to provide any desired number of passages and openings to provide a desired degree of mixing.
The present disclosure relates in part to coating compositions comprising a bactericidal layer further comprising a bactericidal element and a columnar microstructure, which exerts bactericidal activity toward proximal and distal bacteria within an electrolyte solution (i.e. blood or other bodily fluid). The present disclosure further relates to coating compositions stably adhered to an electrode, which exerts bactericidal activity toward proximal and distal bacteria within an electrolyte solution upon application of an electric potential to the underlying electrode without a loss in efficiency of charge transfer.
The present disclosure relates in part to methods of treating, preventing, and/or ameliorating SARS-CoV-2 infection and/or related inflammatory syndromes by administration of a Maackia amurensis seed lectin (MASL). MASL has a strong affinity for sialic acid modified proteins and may be used as an antiviral agent. This lectin targets the ACE2 receptor, decreases ACE2 expression and glycosylation, suppresses binding of the SARS-CoV-2 spike protein, and decreases expression of inflammatory mediators by oral epithelial cells that cause ARDS in COVID-19 patients.
The Government of the United States, as represented by the Secretary of the Army (USA)
Rowan University (USA)
Inventor
Paquette, Craig Michael
La Scala, John Joseph
Sadler, Joshua Matthew
Palmese, Giuseppe Rafaello
Bassett, Alexander William
Stanzione, Joseph Francis
Abstract
A composition of matter including two optionally substituted phenol or optionally substituted aniline units separated by a furan spacer has been prepared. In particular, the chemical structure has a novolac bridge between the central furan ring and the two attached optionally substituted phenol and/or optionally substituted aniline units. These compounds can be modified to be used in various polymer resins. This new structure reduces toxicity relative to BPA/F, makes use of renewable chemicals, and produces certain beneficial polymer properties.
C07D 407/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
C08F 222/20 - Esters containing oxygen in addition to the carboxy oxygen
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (USA)
Inventor
La Scala, John J.
Bassett, Alexander W.
Stanzione, Iii, Joseph F.
Abstract
Resins and formulations of individual monomers bearing both vinyl ester and epoxy functionality were either synthesized or formulated such that vinyl ester components capable of polymerizing by photo-induced, free radical polymerization were mixed with step-growth epoxy-amine systems, facilitating sequential cure. The vinyl ester component was photopolymerized using vat photopolymerization (VPP). Additionally, the preparation of bio-based photo curable thermosetting resins that have tailorable thermal and mechanical properties is provided. All monomers and polymers described herein are useful in a variety of applications, including additive manufacturing applications.
A multi-material printer for using multiple materials, e.g., bioinks, to quickly fabricate structures, such as high-throughput screening microfluidic chips. The printer's light projector for emits light in an exposure sequence to cure material in an additive manufacturing process. The printer further includes a motion stage operable to move a build platform into and out of the reservoir in coordination with the exposure sequence. The printer further includes an indexing stage having a work table for supporting the reservoir. The indexing stage is operable to selectively align the build platform with multiple different materials of the reservoir. The multiple materials may be arranged at distinct angular positions within a single reservoir, and the indexing stage may be operable to rotate the work table to align the build platform with different materials during the exposure sequence for a quick transition among different materials without refilling of materials, exchange of reservoirs, etc.
B29C 64/106 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
B29C 64/124 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified
B29C 35/08 - Heating or curing, e.g. crosslinking or vulcanising by wave energy or particle radiation
The present disclosure provides methods of controlling the size of cellulose crystals by mixing a first composition comprising cellulose and coagulating this mixture with varying concentrations of hydrogen peroxide.
A device for analyzing body composition provides improved accuracy in measuring body fat, lean body mass and body water using bio-electrical impedance (BIA) measurement. The includes a ring sized to fit a human finger, and including components for passing current. Electrodes are provided for contacting the ring finger of one hand (on an interior portion of the ring), and for making contact with fingers of the opposing hand (on an exterior portion of the ring), so that BIA of the human body can be measured across the human body between the left and right hands, as the result current and voltage applied by the ring. The ring may include components for performing the BIA analysis, or for communicating data to another device for performing the BIA analysis. Results of the analysis may be displayed at the other device, or via a display supported on the ring.
A device for detecting an approaching train at a roadway railway crossing and providing an intervention for avoiding a collision that avoids the need for crossing site approval, installations, etc. and associated hardware and installation costs. The device may be configured as a stand-alone device, as an accessory matable to a motor vehicle (e.g., via an OBD II port), or may be fully integrated into the motor vehicle. The device includes a microphone for receiving an ambient audio signal, and processes the audio signal to determine whether a train is present. If so, the device may provide an audible and/or visual warning signal to a vehicle driver, via the device itself or via components of the motor vehicle. In certain other embodiments, the device is configured to provide a control signal causing operation of braking, engine, steering or other vehicle systems to avoid a collision.
Methods and systems for digitally reconstructing a patient tissue sample are described herein. In one embodiment, the method may include projecting a first structured light pattern onto the patient tissue sample, receiving a first reflection of the first structured light pattern from the patient tissue sample, and reconstructing the patient tissue sample based on the first reflection and the projected first structured light pattern. In another embodiment, the system may include a projector adapted or configured to project the first structured light onto the patient tissue sample, a charge-coupled device (CCD) adapted or configured to receive the first reflection from the patient tissue sample, and a reconstruction device adapted or configured to reconstruct the patient tissue sample based on the first reflection and the projected first structured light pattern.
The present disclosure is directed to methods and kits for using serum biomarkers, including C-X-C Motif Chemokine Ligand 10 (CXCL10), C-X-C Motif Chemokine Ligand 13 (CXCL13), and/or soluble CD27 (sCD27), in predicting and evaluating therapeutic response to Tumor Necrosis Factor (TNF) inhibitor therapy in a patient in need thereof.
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
C07K 16/24 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
78.
Methods of Treating or Preventing Amyotrophic Lateral Sclerosis
This disclosure provides methods for treating, ameliorating, or reversing at least one symptom of amyotrophic lateral sclerosis (ALS) in a subject by increasing the amount of neuronal aspartate in spinal cord through administration of a therapeutically effective amount of a composition comprising a nucleic acid encoding ASPA or a functional fragment thereof.
The present invention relates in part to a polymer functionalized with a bio-ionic liquid to form a gel electrolyte. The gel electrolyte thus formed is biocompatible and biodegradable. In certain embodiments, the electrolyte is used for making implantable 3D printed energy storage devices.
Compact, light-weight, handheld printer devices are capable of delivering multi-part materials in mixed form, with controllable dwell-time within the device to allow for a desired amount of physical mixing and chemical cross-linking, while also allowing for deposition of the material directly onto a deposition site. A pen-style printer having a slim but elongated form factor is particularly suitable for depositing biomaterials directly onto a surgical site in the throat. The device may be configured to receive and dispense materials directly from conventional syringes. The printer device may be configured for dispensing and mixing materials having two or more component parts, and may include a leadscrew mechanism providing mechanical advantage, for dispensing higher-viscosity materials, and/or an enhanced degree of precision in dispensing a quantity of material. The mixing time and quantities can be controlled by varying one or more of syringe size and/or injector passage size and mixing chamber length.
The invention relates to non-woven protein fibers and to methods for forming and producing the same. In certain embodiments, the invention provides a method of processing a protein comprising dissolving a protein in a solution, optionally removing any insoluble materials from the solution, and spraying the solution under an applied pressure. In other embodiments, the protein can be derived from a range of sources, including but not limited to arthropod silks, animal keratin (e.g. hair and wool), tissue elastin, collagen, resilin, and plant protein. In certain embodiments, the methods of the invention are an alternative to electrospinning methods known in the art.
B29C 41/08 - Coating a former, core or other substrate by spraying or fluidisation, e.g. spraying powder
B29C 41/24 - Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped articleApparatus therefor for making articles of indefinite length
B29C 41/28 - Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped articleApparatus therefor for making articles of indefinite length by depositing flowable material on an endless belt
The present invention relates to innovative means of DNA sequence editing involving in-situ cut-and-paste (iCAP) or alternatively cut-and-paste in-situ (CAPi). Thus, in various embodiments described herein, the methods of the invention relate to methods of generating paired-end nucleic acid fragment sharing common linker nucleic acid sequences using a nicking endonuclease, a T7 endonuclease, a restriction enzyme or a transposase, methods of analyzing the nucleotides sequences from the linked-paired-end sequenced fragments and methods of de novo whole genome mapping.
Disclosed are various approaches for estimating uncertainty in deep neural networks. A respective tensor normal distribution can be applied to each of a plurality of convolutional kernels of a convolutional neural network, wherein the respective tensor normal distribution captures a correlation and a variance heteorgeneity of each of the plurality of convolutional kernels. Then, the mean and covariance of each respective tensor normal distribution passing through the non-linear activation function of each nonlinear perceptron can be approximated. Next, a max-pool operation can be performed on a plurality of outputs of the plurality of non-linear perceptrons to generate an output tensor. Then, the output tensor can be vectorized to create an input vector for a fully-connected layer of the convolutional neural network. Subsequently, an output vector can be generated using the fully-connected layer. Then, a mean matrix and a covariance matrix for the output vector can be computed.
The present invention provides a data collection system comprising: a camera; a location module; a plurality of sensors; and a first processor communicatively coupled to the camera and the location module, the first processor programmed to: obtain a plurality of frames from the camera; obtain a plurality of locations from the location module; obtain a plurality of data measurements from the plurality of sensors; apply a previously trained first neural network model for identifying problematic road segments to frames captured by the camera; and if the first neural network model indicates that a frame is a problematic road segment, save the frame in association with a location provided by the location module.
G06V 20/58 - Recognition of moving objects or obstacles, e.g. vehicles or pedestriansRecognition of traffic objects, e.g. traffic signs, traffic lights or roads
G06K 9/62 - Methods or arrangements for recognition using electronic means
The present invention relates to the discovery of methods of treating a wound in a subject in need thereof. In certain embodiments, the method comprises contacting the wound with a composition comprising gelatin methacrylate and choline acrylate, and then polymerizing the composition to form a polymerized composition having a plurality of choline acrylate functionalized gelatin methacrylate units.
Methods for detecting positional movement of orthopedic implants are described herein. In one embodiment, the method may include receiving a two-dimensional image defining an image plane, the two-dimensional image capturing a reference marker received within the bone and an orthopedic implant received within a bone, calculating a first angle of the reference marker relative to the image plane based on previously stored dimensions of the reference marker, calculating a second angle of the orthopedic implant relative to the image plane based on previously stored dimensions of the orthopedic implant, comparing the first angle to the second angle to calculate a current angle of rotation, and comparing the current angle of rotation to a previously calculated angle of rotation to detect rotation of the orthopedic implant relative to the bone.
A computer-implemented method for diagnosing a neurological or medical condition of a patient is described herein. In one embodiment, the computer-implemented method may include presenting a set of values via a graphical user interface or an audio speaker, receiving at least a first response from the patient based on the presented set of values, determining at least one time lapse between presenting the set of values and receiving the at least first response, and identifying the neurological or medical condition of the patient based on the at least one time lapse.
A61B 5/16 - Devices for psychotechnicsTesting reaction times
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
90.
Biocompatible oxygen gas generating devices for tissue engineering
The present invention relates to novel biocompatible oxygen gas generating devices that can be implanted into a living subject. In certain embodiments, the oxygen gas generating devices can be used to deliver oxygen gas to tissue in a subject, thereby stimulating tissue growth and repair. In other embodiments, the devices operate by electrolytically splitting endogenous water in a subject. In yet other embodiments, the device further comprises an implantable supercapacitor capable of supplying energy to the oxygen gas generating device.
A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests
A61L 31/14 - Materials characterised by their function or physical properties
H01M 4/58 - Selection of substances as active materials, active masses, active liquids of inorganic compounds other than oxides or hydroxides, e.g. sulfides, selenides, tellurides, halogenides or LiCoFySelection of substances as active materials, active masses, active liquids of polyanionic structures, e.g. phosphates, silicates or borates
H01M 4/583 - Carbonaceous material, e.g. graphite-intercalation compounds or CFx
A61L 27/58 - Materials at least partially resorbable by the body
A61M 1/16 - Dialysis systemsArtificial kidneysBlood oxygenators with membranes
The present invention provides methods, compositions, and kits for the detection of Early-Stage Alzheimer's disease (AD) autoantibody biomarkers, for the diagnosis of Early-Stage AD, for the identification of a subject at risk for developing Early-Stage AD, and/or for the generation of patient-specific Early-Stage AD autoantibody biomarker profiles.
An impact shield for earthquake protection is described herein. The impact shield may include a canopy constructed of a puncture-resistant material, the canopy defining a first internal volume accessible via a first opening, the canopy being structured to form a semispherical shape when in an inflated state, the semispherical shape defining a space dimensioned for sheltering at least one human body; a support joined to the canopy and constructed of the puncture-resistant material, the support defining a second internal volume accessible via the first opening and a second opening, the support located within the space, the support structured to form a column when in the inflated state; and a fitting joined to the support for closing the second opening to fix the first internal volume and the second internal volume after inflation of the support and the canopy.
E04H 9/02 - Buildings, groups of buildings or shelters adapted to withstand or provide protection against abnormal external influences, e.g. war-like action, earthquake or extreme climate withstanding earthquake or sinking of ground
E04H 15/20 - Tents or canopies, in general inflatable, e.g. shaped, strengthened or supported by fluid pressure
E04H 15/36 - Supporting means, e.g. frames arch-shaped type
E04H 9/16 - Buildings, groups of buildings or shelters adapted to withstand or provide protection against abnormal external influences, e.g. war-like action, earthquake or extreme climate against adverse conditions, e.g. extreme climate, pests
E04H 9/10 - Independent sheltersArrangement of independent splinter-proof walls
E04H 9/14 - Buildings, groups of buildings or shelters adapted to withstand or provide protection against abnormal external influences, e.g. war-like action, earthquake or extreme climate against other dangerous influences, e.g. tornadoes, floods
F41H 5/24 - ArmourArmour platesShields for stationary use, e.g. fortifications
A method and computer-based system is provided that assists physicians in detecting early tumor growth and allowing modification of treatment to have a positive impact on medical management, patient morbidity, outcomes and survival times. The method comprises measuring tumor volumes from radiological images to predict growth by a statistical method. The methods allow detection of increases in tumor size earlier than is currently possible and, therefore, advantageous in modifying or optimizing treatment.
M. vaccae immunization reduces addiction- and relapse-like responding in models of cocaine addiction and alter the development of cocaine-induced neuroinflammation.
A surgical robot includes a fixed frame and a moving frame, each having an open space in a center region and may be formed as a partially open ring. The robot also includes three leg structures connecting the fixed frame and the moving frame, and enabling the moving frame to move relative to the fixed frame. The robot also includes a stabilizer for holding an anatomical structure in the open space of each frame. Each leg structure may include a linear component coupled to the moving frame, a rotary component mounted to the fixed frame, and a connector connecting between the two. Each of the linear component and the rotary component may have a rotary actuator that can be controlled by a computer. The robot may be controllable by a computer to assist a reduction procedure of long bone fractures or pelvis surgery.
A61B 34/00 - Computer-aided surgeryManipulators or robots specially adapted for use in surgery
A61B 17/62 - Ring frames, i.e. devices extending around the bones to be positioned
A61B 90/50 - Supports for surgical instruments, e.g. articulated arms
A61B 17/00 - Surgical instruments, devices or methods
A61B 17/88 - Methods or means for implanting or extracting internal fixation devices
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
This invention relates to the detection and quantification of D-dimer levels in a sample derived from a patient having or suspected of having periprosthetic joint infection (PJI) and subsequent diagnosis of PJI.
The United States of America as Represented by the Secretary of the Army (USA)
Inventor
Bassett, Alexander W.
Stanzione, Iii, Joseph F.
La Scala, John J.
Sadler, Joshua M.
Stecca, Owen M.
Abstract
The present invention relates to the unexpected discovery of novel multi-aromatic, multi-substituted compounds. In certain embodiments, the compounds of the invention are generated by condensing at least two phenolic- and/or aniline-containing monomers and an aromatic, aliphatic or heteroaromatic aldehyde- and/or ketone-containing monomer. In other embodiments, at least one monomer is isolated from a bio-based resource. In yet other embodiments, the compounds of the invention are bis- or poly-phenolic compounds.
C07D 407/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
C07C 43/23 - Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
The present invention provides a novel method of treatment for treating brain disorders that manifest oxidative stress by providing targeted populations of neurons with the ability to catabolize the acetylated amino acid derivative, N-acetylaspatic acid (NAA) and further supply extraphysiological levels of ATP to neurons via the targeted expression of the NAA catabolic enzyme aspartoacylase (ASPA) in neurons and astrocytes.
A device for analyzing body composition provides improved accuracy in measuring body fat, lean body mass and body water using bio-electrical impedance (BIA) measurement. The includes a ring sized to fit a human finger, and including components for passing current. Electrodes are provided for contacting the ring finger of one hand (on an interior portion of the ring), and for making contact with fingers of the opposing hand (on an exterior portion of the ring), so that BIA of the human body can be measured across the human body between the left and right hands, as the result current and voltage applied by the ring. The ring may include components for performing the BIA analysis, or for communicating data to another device for performing the BIA analysis. Results of the analysis may be displayed at the other device, or via a display supported on the ring.
This disclosure provides methods for treating, ameliorating, or reversing at least one symptom of amyotrophic lateral sclerosis (ALS) in a subject by increasing the amount of neuronal aspartate in spinal cord through administration of a therapeutically effective amount of a composition comprising a nucleic acid encoding ASPA or a functional fragment thereof.
