Rowan University

United States of America

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G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids 14
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1.

METHOD FOR DETECTING RADIOLOGICAL PROGRESSION IN CANCER SURVEILLANCE

      
Application Number 18989230
Status Pending
Filing Date 2024-12-20
First Publication Date 2025-07-03
Owner
  • THE UAB RESEARCH FOUNDATION (USA)
  • ROWAN UNIVERSITY (USA)
Inventor
  • Fathallah-Shaykh, Hassan
  • Bouaynaya, Nidhal

Abstract

A method and computer-based system is provided that assists physicians in detecting early tumor growth, for example, glioblastoma (GMB) and low-grade gliomas, and allowing modification of treatment to have a positive impact on medical management, patient morbidity, outcomes and survival times. The method comprises measuring tumor volumes from radiological images to predict growth by a statistical method. The methods allow detection of increases in tumor size earlier than is currently possible and, therefore, advantageous in modifying or optimizing treatment.

IPC Classes  ?

  • G06T 7/00 - Image analysis
  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications

2.

NERVE STIMULATION DEVICE FOR CHRONIC PAIN MANAGEMENT

      
Application Number 18845357
Status Pending
Filing Date 2023-03-09
First Publication Date 2025-06-26
Owner
  • ROWAN UNIVERSITY (USA)
  • THE COOPER HEALTH SYSTEM (USA)
Inventor
  • Xue, Wei
  • Hettinger, Jeffrey
  • Hu, Xiao
  • Hirsh, Robert

Abstract

A nerve stimulation device for delivering pain management electrical pulses to nerves includes a flexible substrate that is skin-mountable or implantable. An implantable lead includes microelectrodes provided with a coating for improving charge delivery via a porous electrode structure, and/or to reduce infection risk. In one embodiment, a flexible-substrate wearable energy transmitter patch transmits a power signal wirelessly (e.g., via induction coils) through the skin to an implanted flexible-substrate stimulator component that receives the power signal, generates a tonic signal for pain mitigation, and delivers the tonic signal to nerve stimulation points adjacent the electrodes of an implanted lead. In another embodiment, a flexible-substrate stimulator includes a power source and pulse generator, and the tonic signal is transmitted wirelessly through the skin to an implanted lead having electrodes for delivering the pulses to the stimulation points. Accordingly, the device can be worn without skin perforation, which reduces infection risk.

IPC Classes  ?

  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
  • A61L 31/08 - Materials for coatings
  • A61L 31/14 - Materials characterised by their function or physical properties
  • A61L 31/16 - Biologically active materials, e.g. therapeutic substances
  • A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
  • A61N 1/378 - Electrical supply

3.

LIPID NANOPARTICLES FOR INDUCING PROTEIN EXPRESSION IN THE PLACENTA

      
Application Number US2024061190
Publication Number 2025/137397
Status In Force
Filing Date 2024-12-19
Publication Date 2025-06-26
Owner ROWAN UNIVERSITY (USA)
Inventor Young, Rachel

Abstract

Disclosed is an ionizable lipid nanoparticle (LNP) composition having four lipid components: C12-200, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE), cholesterol, and (1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)) (DMPE-PEG). The LNP composition is useful for delivering RNA to the placenta, thus also providing methods of treating placenta-related disorders.

IPC Classes  ?

  • A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
  • A61P 15/00 - Drugs for genital or sexual disordersContraceptives
  • A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
  • A61K 38/18 - Growth factorsGrowth regulators
  • A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy

4.

CHONDROPLASTY TOOL

      
Application Number 19053004
Status Pending
Filing Date 2025-02-13
First Publication Date 2025-06-19
Owner ROWAN UNIVERSITY (USA)
Inventor
  • Brewer, Erik C.
  • Mahon, Jacob
  • Francis, Maura
  • Covely, Brennen
  • Fanok, Stephanie
  • Hardenbrook, Frederick
  • Oteri, Joseph
  • Struble, Samantha
  • Mcmillan, Sean
  • Intintoli, Alfred
  • Patrinicola, Angelo

Abstract

A device for harvesting cartilage from a subject in a minimally invasive manner, and methods of use thereof, are provided.

IPC Classes  ?

  • A61B 10/02 - Instruments for taking cell samples or for biopsy
  • A61B 17/00 - Surgical instruments, devices or methods
  • A61B 17/32 - Surgical cutting instruments
  • A61B 17/56 - Surgical instruments or methods for treatment of bones or jointsDevices specially adapted therefor

5.

METHOD FOR HIGH-THROUGHPUT LIQUID CHROMATOGRAPHY

      
Application Number 18974273
Status Pending
Filing Date 2024-12-09
First Publication Date 2025-06-12
Owner
  • REGENTS OF THE UNIVERSITY OF MICHIGAN (USA)
  • ROWAN UNIVERSITY (USA)
Inventor
  • Kennedy, Robert
  • Grinias, James
  • Parker, Deklin
  • Foster, Samuel
  • Xin, Yue
  • Makey, Devin
  • Knecht, George Thomas

Abstract

A method for introduction of a sample into a liquid chromatography column with improved speed and reduced time between injections can utilize a segmented sample array that segments samples between segmenting fluid plugs to allow for substantially simultaneous injection of samples from an injection valve and preparation for next sample loading into the injection valve.

IPC Classes  ?

  • G01N 30/20 - Injection using a sampling valve
  • G01N 30/02 - Column chromatography
  • G01N 30/32 - Control of physical parameters of the fluid carrier of pressure or speed

6.

HYDROGEL COMPOSITIONS COMPRISING SYNERGISTIC ANTIMICROBIAL PEPTIDES (AMPS) AND METHODS OF MAKING SAME

      
Application Number US2024055741
Publication Number 2025/106551
Status In Force
Filing Date 2024-11-13
Publication Date 2025-05-22
Owner ROWAN UNIVERSITY (USA)
Inventor
  • Vega, Sebastian L.
  • Carabetta, Valerie J.
  • Recktenwald, Matthias W.

Abstract

The present disclosure relates to antibacterial hydrogel compositions comprising a synergistic combination of antimicrobial peptides, and methods and kits for preparing the same.

IPC Classes  ?

  • C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving viable microorganisms
  • C07K 14/31 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
  • C08B 37/08 - ChitinChondroitin sulfateHyaluronic acidDerivatives thereof

7.

POINT-OF-CARE TEST DIAGNOSTIC MARKERS AND ADJUVANT TREATMENTS FOR GASTROINTESTINAL DISEASES

      
Application Number US2024041604
Publication Number 2025/075714
Status In Force
Filing Date 2024-08-09
Publication Date 2025-04-10
Owner
  • ROWAN UNIVERSITY (USA)
  • THE COOPER HEALTH SYSTEM (USA)
Inventor
  • Phadtare, Sangita U.
  • Desipio, Joshua
  • Perez, Lark J.

Abstract

MonoglobaceaeLachnospiraceaeRuminococcaceaeRuminococcaceae bacterium, as well as a method of treating IBS using the same.

IPC Classes  ?

  • A23L 33/135 - Bacteria or derivatives thereof, e.g. probiotics
  • A61K 35/74 - Bacteria
  • A61K 35/66 - Microorganisms or materials therefrom
  • A61K 39/02 - Bacterial antigens
  • A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system
  • A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives

8.

ASSEMBLY OF POLYMER STAPLE NANOFIBER YARN

      
Application Number 18832559
Status Pending
Filing Date 2023-01-25
First Publication Date 2025-03-27
Owner Rowan University (USA)
Inventor Beachley, Vince

Abstract

The present disclosure provides a system and method for producing nanofibers. The system includes an automated track system including a first track having a first face; and a second track having a second face facing the first face of the first track. The first track and the second track are positioned to define a proximal gap and a distal gap. The first track and the second track are adapted and configured to transfer a nanofiber coupled to the first face and the second face from the proximal gap to the distal gap. The system also includes a roving belt that is positioned to be partially disposed within the distal gap and is adapted and configured to decouple the nanofiber from the first face and the second face.

IPC Classes  ?

  • D01D 5/00 - Formation of filaments, threads, or the like
  • D01D 5/26 - Formation of staple fibres
  • D01D 7/00 - Collecting the newly-spun products

9.

SYSTEMS FOR PRODUCING FIBERS AND RELATED METHODS

      
Application Number US2024045561
Publication Number 2025/054435
Status In Force
Filing Date 2024-09-06
Publication Date 2025-03-13
Owner ROWAN UNIVERSITY (USA)
Inventor
  • Ippolito, Jason
  • Beachley, Vince

Abstract

Provided herein is a system for producing fibers. The system includes a centrifugal spinning apparatus including a centrifugal spinning device configured to produce one or more fibers in a radial direction; a fiber collection apparatus including a collection element positioned relative to the centrifugal spinning apparatus and a collection surface on the collection element, wherein the collection surface is arranged and disposed to contact the one or more fibers produced by the centrifugal spinning apparatus; and a drive mechanism configured to move at least a portion of at least one of the centrifugal spinning apparatus and the fiber collection apparatus in a transverse direction with respect to the other. Also provided herein is a method of producing fibers using the system.

IPC Classes  ?

  • D01D 5/18 - Formation of filaments, threads, or the like by means of rotating spinnerets
  • D01D 5/38 - Formation of filaments, threads, or the like during polymerisation
  • B04B 5/00 - Other centrifuges
  • C03B 37/04 - Manufacture of glass fibres or filaments by using centrifugal force
  • D01D 5/00 - Formation of filaments, threads, or the like
  • D01D 7/02 - Collecting the newly-spun products in centrifugal spinning pots

10.

METALLIC CLUSTER MODIFIED NANOPORE SENSING FOR PEPTIDE DETECTION

      
Application Number 18812166
Status Pending
Filing Date 2024-08-22
First Publication Date 2025-02-27
Owner
  • Virginia Commonwealth University (USA)
  • ROWAN UNIVERSITY (USA)
Inventor
  • Reiner, Joseph E.
  • Bertino, Massimo F.
  • Caputo, Gregory

Abstract

Methods of detecting cysteine-containing peptides are provided. The methods include steps of contacting a resistive-pulse nanopore sensing system with a sample containing cysteine-containing peptides of at least 10 amino acid residues in length, wherein the resistive-pulse nanopore sensing system comprises thiolate-capped gold clusters arranged in a cis side of nanopores and detecting a change in current indicative of exchange between a cysteine-containing peptide and the thiolate-capped gold clusters.

IPC Classes  ?

  • G01N 33/487 - Physical analysis of biological material of liquid biological material
  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

11.

DEVICES, SYSTEMS, AND METHODS OF POSITIONING BONE SEGMENTS

      
Application Number US2024037613
Publication Number 2025/015173
Status In Force
Filing Date 2024-07-11
Publication Date 2025-01-16
Owner ROWAN UNIVERSITY (USA)
Inventor
  • Abedin-Nasab, Mohammad
  • Saeedi-Hosseiny, Marzieh

Abstract

A device for orienting bone fragments is provided herein. The device includes a support element, at least three positional markers disposed on the support element, and at least three optical tracking markers disposed on the support element. Also provided herein are a system including the device and a method of monitoring bone fragment positioning in real-time using the device.

IPC Classes  ?

  • A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
  • A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
  • A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
  • A61B 17/56 - Surgical instruments or methods for treatment of bones or jointsDevices specially adapted therefor

12.

MULTI-SESSION SUPPORT SYSTEM FOR HEALTHCARE PROFESSIONALS

      
Application Number 18739516
Status Pending
Filing Date 2024-06-11
First Publication Date 2024-12-26
Owner Rowan University (USA)
Inventor
  • Tremoulet, Patrice D.
  • Lobo, Andrea
  • Simmons, Christina
  • Baliga, Ganesh

Abstract

A multi-session support system for caregivers that enables quick and easy data collection in a first (notetaking) computing session, synchronously with the delivery of care to multiple patients in a multi-patient care session. Further, the system allows the informal care information notation records developed in the first computing session (e.g., on a mobile phone during a work shift) to be reviewed, edited, augmented, etc. in a second (formal care documentation record creation) computing session, which may be conducted at a later time on a different computing platform (e.g., on a desktop computer after the end of a work shift). Accordingly, the present invention helps to reduce the care documentation burden, by allowing caregivers to take short notes synchronously with the delivery of care, and to prepare formal documentation based on the notes asynchronously with the delivery of care, so that neither patient care nor care documentation are compromised.

IPC Classes  ?

  • G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
  • G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation

13.

MULTI-SESSION SUPPORT SYSTEM FOR HEALTHCARE PROFESSIONALS

      
Application Number US2024033348
Publication Number 2024/263434
Status In Force
Filing Date 2024-06-11
Publication Date 2024-12-26
Owner ROWAN UNIVERSITY (USA)
Inventor
  • Tremoulet, Patrice
  • Lobo, Andrea
  • Simmons, Christina
  • Baliga, Ganesh

Abstract

A multi-session support system for caregivers that enables quick and easy data collection in a first (notetaking) computing session, synchronously with the delivery of care to multiple patients in a multi-patient care session. Further, the system allows the informal care information notation records developed in the first computing session (e.g., on a mobile phone during a work shift) to be reviewed, edited, augmented, etc. in a second (formal care documentation record creation) computing session, which may be conducted at a later time on a different computing platform (e.g., on a desktop computer after the end of a work shift). Accordingly, the present invention helps to reduce the care documentation burden, by allowing caregivers to take short notes synchronously with the delivery of care, and to prepare formal documentation based on the notes asynchronously with the delivery of care, so that neither patient care nor care documentation are compromised.

IPC Classes  ?

  • G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
  • G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
  • G16H 80/00 - ICT specially adapted for facilitating communication between medical practitioners or patients, e.g. for collaborative diagnosis, therapy or health monitoring

14.

COMPOSITIONS AND METHODS FOR CELL CULTURE APPLICATIONS

      
Application Number US2024032431
Publication Number 2024/254082
Status In Force
Filing Date 2024-06-04
Publication Date 2024-12-12
Owner ROWAN UNIVERSITY (USA)
Inventor
  • Vernengo, Andrea
  • Weiser, Jennifer

Abstract

The present disclosure generally relates methods and compositions comprising thermosensitive hydrogel compositions that can be used for embedded patterning of cells, cell aggregates, or organoids. The present disclosure further generally relates to methods of inducing cell condensation into geometrically directed tissue structures and simultaneously producing therapeutic cell secretomes.

IPC Classes  ?

  • A61L 24/04 - Surgical adhesives or cementsAdhesives for colostomy devices containing macromolecular materials
  • A61L 27/22 - Polypeptides or derivatives thereof
  • A61L 27/38 - Animal cells
  • A61L 27/52 - Hydrogels or hydrocolloids
  • A61L 27/54 - Biologically active materials, e.g. therapeutic substances

15.

METHOD FOR RECYCLING CONCRETE MATERIALS TO PRODUCE RECLAIMED CONCRETE AGGREGATE MATERIAL FOR USE IN CONCRETE-BASED MATERIALS AND STRUCTURES

      
Application Number 18672172
Status Pending
Filing Date 2024-05-23
First Publication Date 2024-11-28
Owner Rowan University (USA)
Inventor
  • Abubakri, Shahriar
  • Lomboy, Gilson R.
  • Pizzillo, Joshua Jacob

Abstract

An environmentally-friendly approach to producing concrete using reclaimed concrete aggregate material is provided. Reclaimed concrete aggregate material is obtained by processing recycled concrete aggregate (RCA) waste materials with an impact treatment. The RCA contains natural stone or other aggregate particles that has cementitious material bonded thereto. The impact treatment removes at least a portion of the cementitious material from the aggregate particles, leaving reclaimed concrete aggregate particles having sufficiently little bonded cementitious material so as to be a suitable alternative to virgin aggregate in asphalt and concrete mixes, even for concrete that will be used in structural load-bearing applications for use to construct structural members of buildings and other structures. The impact treatment may be performed by tumbling RCA with impactors in a rotating drum.

IPC Classes  ?

  • C04B 18/167 - Recycled materials, i.e. waste materials reused in the production of the same materials
  • C04B 20/02 - Treatment

16.

CARBON SEQUESTERING INFRASTRUCTURE

      
Application Number US2024030929
Publication Number 2024/243482
Status In Force
Filing Date 2024-05-24
Publication Date 2024-11-28
Owner ROWAN UNIVERSITY (USA)
Inventor Mantawy, Islam

Abstract

Carbon sequestering infrastructure incorporates carbon-sequestering cladding members that are separate and distinct from structural elements configured to carry a structural load of the infrastructure. The cladding is capable of capturing and sequestering carbon from carbon dioxide in atmospheric/ambient air. The cladding may be distinct members having a high carbon capture capacity (but a low compressive strength unsuitable for use in a structural member) attached to structural members having a lower carbon capture capacity (and a higher compressive strength suitable for use in a structural member). The cladding member may be formed as an envelope suitable for use as a form in casting a structural member. Infrastructure elements including cladding may be configured such that the cladding is removable and replaceable after is carbon sequestering capacity is diminished, to allow for carbon sequestration over the entire length of the infrastructure.

IPC Classes  ?

  • C01B 32/60 - Preparation of carbonates or bicarbonates in general
  • C04B 14/28 - Carbonates of calcium

17.

CARBON SEQUESTERING INFRASTRUCTURE

      
Application Number 18673512
Status Pending
Filing Date 2024-05-24
First Publication Date 2024-11-28
Owner Rowan University (USA)
Inventor Mantawy, Islam M.

Abstract

Carbon sequestering infrastructure incorporates carbon-sequestering cladding members that are separate and distinct from structural elements configured to carry a structural load of the infrastructure. The cladding is capable of capturing and sequestering carbon from carbon dioxide in atmospheric/ambient air. The cladding may be distinct members having a high carbon capture capacity (but a low compressive strength unsuitable for use in a structural member) attached to structural members having a lower carbon capture capacity (and a higher compressive strength suitable for use in a structural member). The cladding member may be formed as an envelope suitable for use as a form in casting a structural member. Infrastructure elements including cladding may be configured such that the cladding is removable and replaceable after is carbon sequestering capacity is diminished, to allow for carbon sequestration over the entire length of the infrastructure.

IPC Classes  ?

  • E04F 13/14 - Coverings or linings, e.g. for walls or ceilings composed of covering or lining elementsSub-structures thereforFastening means therefor composed of a plurality of similar covering or lining elements of stone or stone-like materials, e.g. ceramicsCoverings or linings, e.g. for walls or ceilings composed of covering or lining elementsSub-structures thereforFastening means therefor composed of a plurality of similar covering or lining elements of glass
  • B01D 53/62 - Carbon oxides
  • B33Y 70/00 - Materials specially adapted for additive manufacturing
  • B33Y 80/00 - Products made by additive manufacturing

18.

METHOD FOR RECYCLING CONCRETE MATERIALS TO PRODUCE RECLAIMED CONCRETE AGGREGATE MATERIAL FOR USE IN CONCRETE-BASED MATERIALS AND STRUCTURES

      
Application Number US2024030702
Publication Number 2024/243378
Status In Force
Filing Date 2024-05-23
Publication Date 2024-11-28
Owner ROWAN UNIVERSITY (USA)
Inventor
  • Abubakri, Shahriar
  • Lomboy, Gilson
  • Pizzillo, Joshua Jacob

Abstract

An environmentally friendly approach to producing concrete using reclaimed concrete aggregate material is provided. Reclaimed concrete aggregate material is obtained by processing recycled concrete aggregate (RCA) waste materials with an impact treatment. The RCA contains natural stone or other aggregate particles that has cementitious material bonded thereto. The impact treatment removes at least a portion of the cementitious material from the aggregate particles, leaving reclaimed concrete aggregate particles having sufficiently little bonded cementitious material so as to be a suitable alternative to virgin aggregate in asphalt and concrete mixes, even for concrete that will be used in structural load-bearing applications for use to construct structural members of buildings and other structures. The impact treatment may be performed by tumbling RCA with impactors in a rotating drum.

IPC Classes  ?

  • C04B 18/167 - Recycled materials, i.e. waste materials reused in the production of the same materials
  • C04B 20/02 - Treatment
  • B02C 23/10 - Separating or sorting of material, associated with crushing or disintegrating with separator arranged in discharge path of crushing or disintegrating zone
  • C04B 18/02 - Agglomerated materials

19.

METHODS OF MONITORING KINETIC PROCESSES IN AMORPHOUS MATERIALS

      
Application Number 18666705
Status Pending
Filing Date 2024-05-16
First Publication Date 2024-11-21
Owner Rowan University (USA)
Inventor Chimenti, Robert V.

Abstract

The present disclosure provides methods for monitoring certain kinetic processes in amorphous materials using low-frequency Raman spectroscopy.

IPC Classes  ?

20.

METHODS OF MONITORING KINETIC PROCESSES IN AMORPHOUS MATERIALS

      
Application Number US2024029791
Publication Number 2024/238854
Status In Force
Filing Date 2024-05-16
Publication Date 2024-11-21
Owner ROWAN UNIVERSITY (USA)
Inventor Chimenti, Robert V.

Abstract

The present disclosure provides methods for monitoring certain kinetic processes in amorphous materials using low-frequency Raman spectroscopy.

IPC Classes  ?

  • G01J 3/44 - Raman spectrometryScattering spectrometry
  • G01N 21/3563 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing solidsPreparation of samples therefor
  • G01N 21/3581 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using far infrared lightInvestigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using Terahertz radiation

21.

DEVICE FOR TESTING VAPORIZABLE FLUIDS IN A HUMAN AIRWAY MODEL

      
Application Number 18679043
Status Pending
Filing Date 2024-05-30
First Publication Date 2024-09-26
Owner Rowan University (USA)
Inventor
  • Manna, Vincent
  • Caradonna, Salvatore

Abstract

A testing device for testing the impact of aerosolized compounds, such as e-cigarette vapors, metered-dose inhaled corticosteroids, and nebulized medications, on a human airway model system/tissue for purposes related to basic and clinical research, diagnostics, and personalized medicine. The device includes an intake fan assembly, a housing defining an exposure chamber, a holder supported on said housing for supporting an aerosol-generating device; and a control system operable to selectively energize the intake fan to draw the aerosolized compound into the exposure chamber, where human tissue is disposed. The testing device may also include an actuator operable by the control system to cause the aerosol-generating device to generate the aerosolized compound. The testing device may also include an exhaust fan operable by the control system to exhaust the aerosolized compound from the exposure chamber. Testing device components may be constructed of a biocompatible material that is autoclavable without detrimental degradation.

IPC Classes  ?

  • G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups

22.

METHODS OF MODIFYING CELLULOSE CRYSTALLINITY

      
Application Number 18673752
Status Pending
Filing Date 2024-05-24
First Publication Date 2024-09-19
Owner
  • Rutgers, The State University of New Jersey (USA)
  • Rowan University (USA)
Inventor
  • Salas De La Cruz, David
  • Hu, Xiao
  • Love, Stacy
  • Verrill, David

Abstract

The present disclosure provides methods of controlling the size of cellulose crystals by mixing a first composition comprising cellulose and coagulating this mixture with varying concentrations of hydrogen peroxide.

IPC Classes  ?

  • C08B 15/08 - Fractionation of cellulose, e.g. separation of cellulose crystallites
  • B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
  • B01D 71/10 - CelluloseModified cellulose
  • C02F 1/44 - Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis
  • C08K 3/04 - Carbon
  • C08K 11/00 - Use of ingredients of unknown constitution, e.g. undefined reaction products
  • C08L 5/08 - ChitinChondroitin sulfateHyaluronic acidDerivatives thereof
  • C08L 67/04 - Polyesters derived from hydroxy carboxylic acids, e.g. lactones

23.

ROOM AIR MONITORING DEVICE

      
Application Number 18679011
Status Pending
Filing Date 2024-05-30
First Publication Date 2024-09-19
Owner Rowan University (USA)
Inventor
  • Manna, Vincent
  • Caradonna, Salvatore

Abstract

A room air monitoring device for exposing human airway model system/tissue or other media to ambient air for air quality monitoring purposes. The device includes a housing defining an exposure chamber, and a chamber cap defining an opening for admitting air into the exposure chamber. The device also includes an intake fan operable to draw ambient air through the chamber cap, into the exposure chamber, and out of the exposure chamber. A temperature maintaining system can heat an interior of the exposure chamber to a temperature approximating a human body tissue temperature. A control system maintains a temperature of the exposure chamber within a desired temperature range, and may selectively energize the electric motor to draw ambient air into the exposure chamber. The testing device components may be constructed of a biocompatible material that is autoclavable without detrimental degradation.

IPC Classes  ?

24.

CHONDROPLASTY TOOL

      
Application Number 18502534
Status Pending
Filing Date 2023-11-06
First Publication Date 2024-08-29
Owner
  • Rowan University (USA)
  • Trice Medical, Inc. (USA)
Inventor
  • Brewer, Erik C.
  • Mahon, Jacob
  • Francis, Maura
  • Covely, Brennen
  • Fanok, Stephanie
  • Hardenbrook, Frederick
  • Oteri, Joseph
  • Struble, Samantha
  • Mcmillan, Sean
  • Intintoli, Alfred
  • Patrinicola, Angelo

Abstract

A device for harvesting cartilage from a subject in a minimally invasive manner, and methods of use thereof, are provided.

IPC Classes  ?

  • A61B 10/02 - Instruments for taking cell samples or for biopsy
  • A61B 17/00 - Surgical instruments, devices or methods
  • A61B 17/32 - Surgical cutting instruments
  • A61B 17/56 - Surgical instruments or methods for treatment of bones or jointsDevices specially adapted therefor

25.

AUTOMATED DETECTION OF COGNITIVE CONDITIONS

      
Application Number 18443973
Status Pending
Filing Date 2024-02-16
First Publication Date 2024-08-22
Owner ROWAN UNIVERSITY (USA)
Inventor
  • Baliga, Ganesh
  • Libon, David J.

Abstract

One aspect of the present disclosure provides for a computer-implemented method for automated detection of cognitive conditions as described herein (e.g., to detect emergent neurocognitive decline consistent with mild cognitive impairment (MCI) and Alzheimer's Disease and Related Dementias (ADRD)).

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

26.

AUTOMATED DETECTION OF COGNITIVE CONDITIONS

      
Application Number US2024016168
Publication Number 2024/173804
Status In Force
Filing Date 2024-02-16
Publication Date 2024-08-22
Owner ROWAN UNIVERSITY (USA)
Inventor
  • Baliga, Ganesh
  • Libon, David J.

Abstract

One aspect of the present disclosure provides for a computer-implemented method for automated detection of cognitive conditions as described herein (e.g., to detect emergent neurocognitive decline consistent with mild cognitive impairment (MCI) and Alzheimer's Disease and Related Dementias (ADRD)).

IPC Classes  ?

  • A61B 5/16 - Devices for psychotechnicsTesting reaction times
  • A61B 3/032 - Devices for presenting test symbols or characters, e.g. test chart projectors
  • G16H 20/70 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mental therapies, e.g. psychological therapy or autogenous training
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons

27.

METHODS AND APPARATUS FOR DETECTING ABNORMAL TISSUE AND OTHER FOREIGN MATTER IN A BODY

      
Application Number US2024013319
Publication Number 2024/163330
Status In Force
Filing Date 2024-01-29
Publication Date 2024-08-08
Owner
  • ROWAN UNIVERSITY (USA)
  • BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY (USA)
Inventor Moghimi, S. Mohammad J.

Abstract

This disclosure pertains to methods, apparatus, systems, and techniques for non-invasively detecting abnormal biological tissue and other abnormal matter in a body.

IPC Classes  ?

  • A61B 3/00 - Apparatus for testing the eyesInstruments for examining the eyes
  • H05K 1/16 - Printed circuits incorporating printed electric components, e.g. printed resistor, capacitor, inductor
  • A61B 3/16 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for measuring intraocular pressure, e.g. tonometers
  • G02C 7/04 - Contact lenses for the eyes
  • A61B 5/335 - Recording apparatus specially adapted therefor using integrated circuit memory devices

28.

MITIGATION OF MALICIOUS SONIC ATTACKS ON VOICE-BASED COMPUTING DEVICES

      
Application Number US2023023459
Publication Number 2024/158407
Status In Force
Filing Date 2023-05-25
Publication Date 2024-08-02
Owner ROWAN UNIVERSITY (USA)
Inventor
  • Shen, Chen
  • Lloyd, Joshua

Abstract

An acoustic filter mitigates audio signal-based attacks (particularly inaudible attacks in the ultrasonic frequency range) on voice-based computing devices by modulating the signals before they reach the device's microphone. One filter is formed as a rigid body defining multiple holes that exhibit local resonance phenomena that suppress incoming audio waves at specific frequencies. The filter distorts or otherwise modifies the attack signals and thereby prevents the microphone(s) from receiving the intended attack signal, and prevents the associated computing device from processing and executing the intended malicious "command"/signal. The filter can be tuned to be operable outside the frequency range of normal spoken commands, so that typical voice-based commands are unaffected by the filter. A frame is provided to enable one or more filters to be retrofitted to existing consumer electronics devices, outside their housings. Alternatively, new consumer electronics may be manufactured to include such filters inside their housings.

IPC Classes  ?

  • H04R 1/28 - Transducer mountings or enclosures designed for specific frequency responseTransducer enclosures modified by provision of mechanical or acoustic impedances, e.g. resonator, damping means
  • H04R 3/14 - Cross-over networks
  • G10K 11/178 - Methods or devices for protecting against, or for damping, noise or other acoustic waves in general using interference effectsMasking sound by electro-acoustically regenerating the original acoustic waves in anti-phase

29.

ABSORBANCE-COUPLED VOLTAGE CONTROL OF ELECTROSPRAY IONIZATION

      
Application Number US2023085162
Publication Number 2024/137825
Status In Force
Filing Date 2023-12-20
Publication Date 2024-06-27
Owner ROWAN UNIVERSITY (USA)
Inventor
  • Grinias, James P.
  • Foster, Samuel
  • Parker, Deklin
  • Piccolo, Christopher

Abstract

Provided herein is a system for applying voltage in electrospray ionization. The system includes an electrospray nozzle arrangement, the electrospray nozzle arrangement including an electrospray nozzle; an in-line absorbance detector; a high voltage power supply electrically coupled to the electrospray nozzle; and a computer-controlled system configured to apply voltage from the high voltage power supply to the electrospray nozzle based upon readings from the in-line absorbance detector. Also provided herein is a method for applying voltage in electrospray ionization using an in-line absorbance detector.

IPC Classes  ?

  • H01J 49/16 - Ion sourcesIon guns using surface ionisation, e.g. field-, thermionic- or photo-emission
  • B05B 5/025 - Discharge apparatus, e.g. electrostatic spray guns
  • G01N 30/72 - Mass spectrometers

30.

SYSTEMS AND METHODS FOR FIBER ZONE-DRAWING AND/OR ZONE-ANNEALING

      
Application Number 18557099
Status Pending
Filing Date 2022-04-25
First Publication Date 2024-06-20
Owner Rowan University (USA)
Inventor
  • Flamini, Matthew
  • Beachley, Vince

Abstract

In one aspect, the present disclosure is related to system and method of manufacturing nanomaterials and particularly to system and method for zone-drawing and/or zone-annealing fibers.

IPC Classes  ?

  • D01F 9/22 - Carbon filamentsApparatus specially adapted for the manufacture thereof by decomposition of organic filaments from polyaddition, polycondensation or polymerisation products from macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds from polyacrylonitriles

31.

METHOD FOR RECYCLING CEMENT-CONTAINING MATERIALS TO PRODUCE RECLAIMED FINES FOR USE IN CEMENT-BASED MATERIALS AND STRUCTURES

      
Application Number 18524709
Status Pending
Filing Date 2023-11-30
First Publication Date 2024-06-13
Owner Rowan University (USA)
Inventor
  • Abubakri, Shahriar
  • Lomboy, Gilson R.
  • Mantawy, Islam M.

Abstract

An environmentally-friendly substitute for virgin dry cement is provided. The substitute is obtained as reclaimed cementitious fines produced by recycling cement-containing waste materials, such as recycled concrete aggregate and demolished brick structures. The reclaimed cementitious fines are used as cementitious material in new concrete, mortar, cement paste and other cement-containing materials and structures. A recycling method involves obtaining cement-containing waste material, crushing the cement-containing waste material, gathering the crushed cement-containing waste materials, the crushed cement-containing waste materials comprising reclaimed particles derived from said cement-containing waste material; and sorting the crushed cement-containing waste materials by particle size to obtain reclaimed cementitious fines having sizes in a desired particle size range, e.g., 0.1 micron to 200 micron for use as a substitute for virgin dry cement powder. Notably, the crushing/tumbling methodologies used to obtain the reclaimed particles produce significantly less carbon dioxide that the methodologies used to obtain virgin dry cement.

IPC Classes  ?

  • C04B 18/167 - Recycled materials, i.e. waste materials reused in the production of the same materials
  • C04B 14/06 - QuartzSand
  • C04B 26/26 - Bituminous materials, e.g. tar, pitch

32.

FORGING FORWARD

      
Serial Number 98552065
Status Pending
Filing Date 2024-05-15
Owner Rowan University ()
NICE Classes  ? 36 - Financial, insurance and real estate services

Goods & Services

Charitable fundraising services, namely conducting fundraising campaigns for the purpose of raising funds to support university academic programs, athletics, scholarships, and facilities

33.

THREE-DIMENSIONAL PRINTABLE BIOCOMPATIBLE PHOTOPOLYMERIZABLE INK WITH SPATIALLY CONTROLLED DUAL PROTEIN MOTIFS FOR CO-CULTURE FUNCTIONALITY

      
Application Number 18216337
Status Pending
Filing Date 2023-06-29
First Publication Date 2024-04-11
Owner Rowan University (USA)
Inventor
  • Galie, Peter Adam
  • Paone, Louis Salvatore

Abstract

A three-dimensional biocompatible photoink useful for three-dimensional printing includes a biocompatible polymer having at least one covalently bonded photoink. The biocompatible photoink can suitably include a photoinitiator, a photo-absorber and a crosslinker and, in some embodiments, may include live tissue cells and an RGD peptide protein.

IPC Classes  ?

34.

A THREE-DIMENSIONAL PRINTABLE BIOCOMPATIBLE PHOTOPOLYMERIZABLE INK WITH SPATIALLY CONTROLLED DUAL PROTEIN MOTIFS FOR CO-CULTURE FUNCTIONALITY

      
Application Number US2023026582
Publication Number 2024/076401
Status In Force
Filing Date 2023-06-29
Publication Date 2024-04-11
Owner ROWAN UNIVERSITY (USA)
Inventor
  • Galie, Peter Adam
  • Paone, Louis Salvatore

Abstract

A three-dimensional biocompatible photoink useful for three-dimensional printing includes a biocompatible polymer having at least one covalently bonded photoink. The biocompatible photoink can suitably include a photoinitiator, a photo-absorber and a crosslinker and, in some embodiments, may include live tissue cells and an RGD peptide protein.

IPC Classes  ?

  • C09D 11/101 - Inks specially adapted for printing processes involving curing by wave energy or particle radiation, e.g. with UV-curing following the printing
  • C09D 11/08 - Printing inks based on natural resins
  • C09D 11/04 - Printing inks based on proteins
  • C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules
  • C08F 2/46 - Polymerisation initiated by wave energy or particle radiation
  • C08L 81/00 - Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing sulfur with or without nitrogen, oxygen, or carbon onlyCompositions of polysulfonesCompositions of derivatives of such polymers
  • B29C 64/00 - Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
  • B33Y 10/00 - Processes of additive manufacturing
  • B33Y 70/00 - Materials specially adapted for additive manufacturing

35.

METHODS OF DETECTING ELECTROMAGNETIC FIELDS, AND SYSTEMS IMPLEMENTING THE SAME

      
Application Number US2023025608
Publication Number 2024/072504
Status In Force
Filing Date 2023-06-16
Publication Date 2024-04-04
Owner ROWAN UNIVERSITY (USA)
Inventor Lim, Michael J.

Abstract

pdcRFcc; coherently transferring the symmetrical RF sidebands to the first beam via a nonlinear wave mixing in the vapor cell; and determining an electromagnetic field inside the vapor cell.

IPC Classes  ?

  • G01R 29/08 - Measuring electromagnetic field characteristics
  • G01R 33/02 - Measuring direction or magnitude of magnetic fields or magnetic flux
  • H01S 3/067 - Fibre lasers
  • H01S 3/0941 - Processes or apparatus for excitation, e.g. pumping using optical pumping by coherent light of a semiconductor laser, e.g. of a laser diode
  • H01S 3/227 - Metal vapour
  • G01N 21/63 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited

36.

METHODS OF PRECISE GENOME EDITING BY IN SITU CUT AND PASTE (ICAP)

      
Application Number 17767944
Status Pending
Filing Date 2020-10-20
First Publication Date 2024-03-28
Owner Rowan University (USA)
Inventor
  • Jiang, Ping
  • Kemper, Kevin M.
  • Caradonna, Salvatore J.

Abstract

The present invention relates to innovative means of DNA sequence editing involving in-situ cut-and-paste (iCAP) or alternatively cut-and-paste in-situ (CAPi). Thus, in various embodiments described herein, the methods of the invention relate to methods of generating paired-end nucleic acid fragment sharing common linker nucleic acid sequences using a nicking endonuclease, a T7 endonuclease, a restriction enzyme or a transposase, methods of analyzing the nucleotides sequences from the linked-paired-end sequenced fragments and methods of de novo whole genome mapping.

IPC Classes  ?

  • A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
  • A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
  • A61K 38/46 - Hydrolases (3)
  • C12N 9/22 - Ribonucleases
  • C12N 15/11 - DNA or RNA fragmentsModified forms thereof
  • C12N 15/90 - Stable introduction of foreign DNA into chromosome

37.

Synthetic Aligned Tissue Grafts and Methods of Using the Same

      
Application Number 18251166
Status Pending
Filing Date 2022-05-27
First Publication Date 2024-02-15
Owner Rowan University (USA)
Inventor
  • Beachley, Vince
  • Vega, Sebastian L.
  • Joa, Dave

Abstract

The present disclosure relates to a multi-layer composite comprising at least a first sheet and a second sheet of aligned nanofibers coated with a biodegradable hydrogel, wherein the at least first and second sheets of aligned coated nanofibers are stacked directly on top of each other and a portion of the biodegradable hydrogel coating on the first sheet is mixed and crosslinked with a portion of the biodegradable hydrogel coating on the second sheet. In another aspect, the present disclosure relates to a method of regenerating an aligned soft tissue in a subject, the method comprising surgically implanting a synthetic tissue graft comprising the multi-layer composite in the subject at a site of missing or injured tissue. In yet another aspect, the present disclosure relates to a synthetic nerve graft comprising the multi-layer composite.

IPC Classes  ?

  • A61L 27/48 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
  • A61L 27/52 - Hydrogels or hydrocolloids
  • A61L 27/58 - Materials at least partially resorbable by the body

38.

HYDROGELS AND METHODS OF USING THE SAME

      
Document Number 03262651
Status Pending
Filing Date 2023-07-21
Open to Public Date 2024-01-25
Owner
  • ROWAN UNIVERSITY (USA)
  • THE COOPER HEALTH SYSTEM (USA)
Inventor
  • Vega, Sebastian L.
  • Gultian, Kirstene
  • Kim, Tae Won B.

IPC Classes  ?

  • A61K 38/18 - Growth factorsGrowth regulators
  • A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
  • A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
  • A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
  • A61L 27/18 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
  • A61L 27/20 - Polysaccharides
  • A61L 27/26 - Mixtures of macromolecular materials
  • A61L 27/52 - Hydrogels or hydrocolloids
  • A61L 27/54 - Biologically active materials, e.g. therapeutic substances
  • C08J 3/075 - Macromolecular gels

39.

HYDROGELS AND METHODS OF USING THE SAME

      
Application Number US2023070731
Publication Number 2024/020558
Status In Force
Filing Date 2023-07-21
Publication Date 2024-01-25
Owner
  • ROWAN UNIVERSITY (USA)
  • THE COOPER HEALTH SYSTEM (USA)
Inventor
  • Vega, Sebastian L.
  • Gultian, Kirstene
  • Kim, Tae Won B.

Abstract

Described herein is a hydrogel including a hydrogel polymer; a crosslinker crosslinking the hydrogel polymer; a biomolecule attached to the hydrogel polymer; and water. In the hydrogel, the biomolecule is attached to the hydrogel polymer through an acrylic linker attached to a hydroxyl group in the hydrogel polymer. Also described is a hyaluronic acid (HA)-based hydrogel including a first HA polymer comprising a first crosslinker; a second HA polymer comprising a second crosslinker; a biomolecule attached to the first HA polymer or the second HA polymer through an acrylic linker attached to a hydroxyl group in the first HA polymer or the second HA polymer; and water. Also described is a method of producing the HA-based hydrogel, as well as a method of regenerating tissues using the hydrogels.

IPC Classes  ?

  • A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
  • A61K 38/18 - Growth factorsGrowth regulators
  • A61L 27/52 - Hydrogels or hydrocolloids
  • A61L 27/54 - Biologically active materials, e.g. therapeutic substances
  • C08J 3/075 - Macromolecular gels
  • A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
  • A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
  • A61L 27/18 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
  • A61L 27/20 - Polysaccharides
  • A61L 27/26 - Mixtures of macromolecular materials

40.

METHODS OF TREATING, AMELIORATING, AND/OR PREVENTING COVID-19 INFECTION AND RELATED INFLAMMATION

      
Application Number 18032018
Status Pending
Filing Date 2021-10-19
First Publication Date 2023-12-07
Owner Rowan University (USA)
Inventor
  • Goldberg, Gary S.
  • Leone, Paola

Abstract

The present disclosure relates in part to methods of treating, preventing, and/or ameliorating SARS-CoV-2 infection and/or related inflammatory syndromes by administration of a Maackia amurensis seed lectin (MASL). MASL has a strong affinity for sialic acid modified proteins and may be used as an antiviral agent. This lectin targets the ACE2 receptor, decreases ACE2 expression and glycosylation, suppresses binding of the SARS-CoV-2 spike protein, and decreases expression of inflammatory mediators by oral epithelial cells that cause ARDS in COVID-19 patients.

IPC Classes  ?

  • C07K 14/42 - Lectins, e.g. concanavalin, phytohaemagglutinin
  • A61K 36/48 - Fabaceae or Leguminosae (Pea or Legume family)CaesalpiniaceaeMimosaceaePapilionaceae
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • A61P 31/14 - Antivirals for RNA viruses
  • A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]

41.

ROOM AIR MONITORING DEVICE

      
Application Number US2023023458
Publication Number 2023/235206
Status In Force
Filing Date 2023-05-25
Publication Date 2023-12-07
Owner ROWAN UNIVERSITY (USA)
Inventor
  • Manna, Vincent
  • Caradonna, Salvatore

Abstract

A room air monitoring device for exposing human airway model system/tissue or other media to ambient air for air quality monitoring purposes. The device includes a housing defining an exposure chamber, and a chamber cap defining an opening for admitting air into the exposure chamber. The device also includes an intake fan operable to draw ambient air through the chamber cap, into the exposure chamber, and out of the exposure chamber. A temperature maintaining system can heat an interior of the exposure chamber to a temperature approximating a human body tissue temperature. A control system maintains a temperature of the exposure chamber within a desired temperature range, and may selectively energize the electric motor to draw ambient air into the exposure chamber. The testing device components may be constructed of a biocompatible material that is autoclavable without detrimental degradation.

IPC Classes  ?

  • G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
  • G01N 15/08 - Investigating permeability, pore volume, or surface area of porous materials
  • G01N 1/24 - Suction devices

42.

DEVICE FOR TESTING VAPORIZABLE FLUIDS IN A HUMAN AIRWAY MODEL

      
Application Number US2023023457
Publication Number 2023/235205
Status In Force
Filing Date 2023-05-25
Publication Date 2023-12-07
Owner ROWAN UNIVERSITY (USA)
Inventor
  • Manna, Vincent
  • Caradonna, Salvatore

Abstract

A testing device for testing the impact of aerosolized compounds, such as e-cigarette vapors, metered-dose inhaled corticosteroids, and nebulized medications, on a human airway model system/tissue for purposes related to basic and clinical research, diagnostics, and personalized medicine. The device includes an intake fan assembly, a housing defining an exposure chamber, a holder supported on said housing for supporting an aerosol-generating device; and a control system operable to selectively energize the intake fan to draw the aerosolized compound into the exposure chamber, where human tissue is disposed. The testing device may also include an actuator operable by the control system to cause the aerosol-generating device to generate the aerosolized compound. The testing device may also include an exhaust fan operable by the control system to exhaust the aerosolized compound from the exposure chamber. Testing device components may be constructed of a biocompatible material that is autoclavable without detrimental degradation.

IPC Classes  ?

  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
  • A24F 40/80 - Testing
  • A24F 42/90 - Testing
  • A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
  • C12N 5/04 - Plant cells or tissues
  • G01N 33/15 - Medicinal preparations
  • G01N 33/483 - Physical analysis of biological material

43.

INJECTABLE DOSIMETER COMPOSITIONS AND METHODS OF USING SAME

      
Application Number US2023024285
Publication Number 2023/235561
Status In Force
Filing Date 2023-06-02
Publication Date 2023-12-07
Owner
  • ROWAN UNIVERSITY (USA)
  • THE COOPER HEALTH SYSTEM (USA)
Inventor
  • Vega, Sebastian L.
  • Gultian, Kirstene
  • Kim, Leonard
  • Malajovich, Irina
  • Ibbott, Geoffrey S.

Abstract

Described herein is a biocompatible injectable dosimeter. The injectable dosimeter comprises a polymer gel and a radiation dosimeter material distributed in the polymer gel. The dosimeter material in the injectable dosimeter, when radiated, generates a dosimetric signal, which can be used to evaluate the delivery of the radiation. Also described are methods of using the injectable dosimeter, such as to report radiation in real-time and to protect tissues adjacent to the disease sites being irradiated.

IPC Classes  ?

44.

Multi-material printer device for manufacture of high-throughput screening microfluidic chips

      
Application Number 17297305
Grant Number 12023856
Status In Force
Filing Date 2021-03-31
First Publication Date 2023-11-02
Grant Date 2024-07-02
Owner ROWAN UNIVERSITY (USA)
Inventor
  • Miri Ramsheh, Amir K.
  • Bhusal, Anant
  • Nguyen, Hai Anh
  • Nieto, Daniel

Abstract

A multi-material printer for using multiple materials, e.g., bioinks, to quickly fabricate structures, such as high-throughput screening microfluidic chips. The printer's light projector for emits light in an exposure sequence to cure material in an additive manufacturing process. The printer further includes a motion stage operable to move a build platform into and out of the reservoir in coordination with the exposure sequence. The printer further includes an indexing stage having a work table for supporting the reservoir. The indexing stage is operable to selectively align the build platform with multiple different materials of the reservoir. The multiple materials may be arranged at distinct angular positions within a single reservoir, and the indexing stage may be operable to rotate the work table to align the build platform with different materials during the exposure sequence for a quick transition among different materials without refilling of materials, exchange of reservoirs, etc.

IPC Classes  ?

  • B29C 64/124 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified
  • B29C 64/241 - Driving means for rotary motion
  • B29C 64/393 - Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
  • B33Y 10/00 - Processes of additive manufacturing
  • B33Y 30/00 - Apparatus for additive manufacturingDetails thereof or accessories therefor
  • B33Y 50/02 - Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes

45.

MOBILE SENSOR-BASED RAILWAY CROSSING SAFETY DEVICE

      
Application Number 17297277
Status Pending
Filing Date 2021-02-18
First Publication Date 2023-11-02
Owner Rowan University (USA)
Inventor
  • Mcglynn, Charles D.
  • Zhang, Hong
  • Diorio, Joseph S.

Abstract

A device for detecting an approaching train at a roadway railway crossing and providing an intervention for avoiding a collision that avoids the need for crossing site approval, installations, etc. and associated hardware and installation costs. The device may be configured as a stand-alone device, as an accessory matable to a motor vehicle (e.g., via an OBD II port), or may be fully integrated into the motor vehicle. The device includes a microphone for receiving an ambient audio signal, and processes the audio signal to determine whether a train is present. If so, the device may provide an audible and/or visual warning signal to a vehicle driver, via the device itself or via components of the motor vehicle. In certain other embodiments, the device is configured to provide a control signal causing operation of braking, engine, steering or other vehicle systems to avoid a collision.

IPC Classes  ?

  • B61L 29/24 - Means for warning road traffic that a gate is closed or closing, or that rail traffic is approaching, e.g. for visible or audible warning

46.

NERVE STIMULATION DEVICE FOR CHRONIC PAIN MANAGEMENT

      
Application Number US2023014903
Publication Number 2023/172680
Status In Force
Filing Date 2023-03-09
Publication Date 2023-09-14
Owner
  • ROWAN UNIVERSITY (USA)
  • THE COOPER HEALTH SYSTEM (USA)
Inventor
  • Xue, Wei
  • Hettinger, Jeffrey
  • Hu, Xiao
  • Hirsh, Robert

Abstract

A nerve stimulation device for delivering pain management electrical pulses to nerves includes a flexible substrate that is skin-mountable or implantable. An implantable lead includes microelectrodes provided with a coating for improving charge delivery via a porous electrode structure, and/or to reduce infection risk. In one embodiment, a flexible-substrate wearable energy transmitter patch transmits a power signal wirelessly (e.g., via induction coils) through the skin to an implanted flexible-substrate stimulator component that receives the power signal, generates a tonic signal for pain mitigation, and delivers the tonic signal to nerve stimulation points adjacent the electrodes of an implanted lead. In another embodiment, a flexible-substrate stimulator includes a power source and pulse generator, and the tonic signal is transmitted wirelessly through the skin to an implanted lead having electrodes for delivering the pulses to the stimulation points. Accordingly, the device can be worn without skin perforation, which reduces infection risk.

IPC Classes  ?

  • A61N 1/18 - Applying electric currents by contact electrodes
  • A61N 1/378 - Electrical supply
  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

47.

EFM EDELMAN FOSSIL PARK & MUSEUM OF ROWAN UNIVERSITY

      
Serial Number 98157951
Status Pending
Filing Date 2023-08-30
Owner Rowan University ()
NICE Classes  ? 41 - Education, entertainment, sporting and cultural services

Goods & Services

Museum services, namely, providing museum services in the fields of dinosaurs and fossils; educational and entertainment services, namely, providing museum attractions in the nature of multimedia displays and exhibits in the fields of dinosaurs and fossils

48.

ASSEMBLY OF POLYMER STAPLE NANOFIBER YARN

      
Document Number 03249577
Status Pending
Filing Date 2023-01-25
Open to Public Date 2023-08-03
Owner Rowan University (USA)
Inventor Beachley, Vince

IPC Classes  ?

  • D01D 5/00 - Formation of filaments, threads, or the like
  • D01D 5/098 - Melt-spinning methods with simultaneous stretching
  • D01D 5/11 - Flash-spinning
  • D01D 5/12 - Stretch-spinning methods
  • D01D 5/16 - Stretch-spinning methods using rollers, or like mechanical devices, e.g. snubbing pins
  • D01D 5/26 - Formation of staple fibres
  • D01D 7/00 - Collecting the newly-spun products

49.

ASSEMBLY OF POLYMER STAPLE NANOFIBER YARN

      
Application Number US2023011538
Publication Number 2023/146913
Status In Force
Filing Date 2023-01-25
Publication Date 2023-08-03
Owner ROWAN UNIVERSITY (USA)
Inventor Beachley, Vince

Abstract

The present disclosure provides a system and method for producing nanofibers. The system includes an automated track system including a first track having a first face; and a second track having a second face facing the first face of the first track. The first track and the second track are positioned to define a proximal gap and a distal gap. The first track and the second track are adapted and configured to transfer a nanofiber coupled to the first face and the second face from the proximal gap to the distal gap. The system also includes a roving belt that is positioned to be partially disposed within the distal gap and is adapted and configured to decouple the nanofiber from the first face and the second face.

IPC Classes  ?

  • D01D 7/00 - Collecting the newly-spun products
  • D01D 5/16 - Stretch-spinning methods using rollers, or like mechanical devices, e.g. snubbing pins
  • D01D 5/12 - Stretch-spinning methods
  • D01D 5/098 - Melt-spinning methods with simultaneous stretching
  • D01D 5/11 - Flash-spinning
  • D01D 5/26 - Formation of staple fibres
  • D01D 5/00 - Formation of filaments, threads, or the like

50.

TRAINING A NEURAL NETWORK FOR A PREDICTIVE AORTIC ANEURYSM DETECTION SYSTEM

      
Application Number US2022018162
Publication Number 2023/132846
Status In Force
Filing Date 2022-02-28
Publication Date 2023-07-13
Owner ROWAN UNIVERSITY (USA)
Inventor
  • Li, Yupeng
  • Nguyen, Hieu Duc
  • Tang, Shao

Abstract

Systems and methods for detecting aortic aneurysms using ensemble based deep learning techniques that utilize numerous computed tomography (CT) scans collected from numerous de-identified patients in a database. The system includes software that automates the analysis of a series of CT scans as input (in DICOM file format) and provides output in two dimensions: (1) ranking CT scans by risks of adverse events from aortic aneurysm, (2) providing aortic aneurysm size estimates. A repository of CT scans may be used for training of deep neural networks and additional data may be drawn from localized patient information from institutions and hospitals which grant permission.

IPC Classes  ?

  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61B 6/03 - Computed tomography [CT]
  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
  • G01N 33/573 - ImmunoassayBiospecific binding assayMaterials therefor for enzymes or isoenzymes
  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

51.

OPTICALLY CLEAR, IN-SITU FORMING BIODEGRADABLE NANO-CARRIERS FOR OCULAR THERAPY, AND METHODS USING SAME

      
Application Number 18091615
Status Pending
Filing Date 2022-12-30
First Publication Date 2023-05-04
Owner Rowan University (USA)
Inventor
  • Byrne, Mark E.
  • George-Weinstein, Mindy
  • Osorno, Laura L.

Abstract

In one aspect, the present invention relates to thermo-reversible hydrogel drug delivery compositions comprising at least one biodegradable copolymer drug carrier. In certain embodiments, the hydrogel compositions of the invention are optically clear and suitable for use in local delivery of ocular therapeutics. In other embodiments, the hydrogel compositions of the invention provide a means for controlled or sustained drug delivery.

IPC Classes  ?

  • A61K 9/107 - Emulsions
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 31/573 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
  • A61K 31/728 - Hyaluronic acid
  • A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
  • A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
  • A61K 47/61 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
  • A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
  • A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit

52.

NETWORK TOUGHENING OF ADDITIVELY MANUFACTURED, HIGH GLASS TRANSITION TEMPERATURE MATERIALS VIA SEQUENTIALLY CURED, INTERPENETRATING POLYMERS

      
Application Number 17799982
Status Pending
Filing Date 2021-02-18
First Publication Date 2023-03-30
Owner
  • Rowan University (USA)
  • The United States of America as Represented by the Secretary of the Army (USA)
Inventor
  • Bassett, Alexander W.
  • Stanzione, Iii, Joseph F.
  • La Scala, John J.

Abstract

Resins and formulations of individual monomers bearing both vinyl ester and epoxy functionality were either synthesized or formulated such that vinyl ester components capable of polymerizing by photo-induced, free radical polymerization were mixed with step-growth epoxy-amine systems, facilitating sequential cure. The vinyl ester component was photopolymerized using vat photopolymerization (VPP). Additionally, the preparation of bio-based photo curable thermosetting resins that have tailorable thermal and mechanical properties is provided. All monomers and polymers described herein are useful in a variety of applications, including additive manufacturing applications.

IPC Classes  ?

  • C08F 220/18 - Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids

53.

VACCINE SITE ASSESSMENT SIMULATOR

      
Application Number 17898002
Status Pending
Filing Date 2022-08-29
First Publication Date 2023-03-09
Owner Rowan University (USA)
Inventor
  • Houshmand, Ali A.
  • Lecakes, Jr., George D.

Abstract

A computer product, including a logical environment system adapted to generate a logical network comprising a plurality of logically related, rule based junctions through which one or more entities traverse, a spatial environment system adapted to map one or more spatial constraints upon each logical relation between each of the one or more of the plurality of junction; and a rendering environment system adapted to move the one or more entities through the logical network subject to the corresponding spatial constraints and to visually display the results of the movement of the one or more entities via a graphical user interface.

IPC Classes  ?

  • G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
  • G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms

54.

Training a neural network for a predictive aortic aneurysm detection system

      
Application Number 17682407
Grant Number 11538163
Status In Force
Filing Date 2022-02-28
First Publication Date 2022-12-27
Grant Date 2022-12-27
Owner ROWAN UNIVERSITY (USA)
Inventor
  • Li, Yupeng
  • Nguyen, Hieu Duc
  • Tang, Shao

Abstract

Systems and methods for detecting aortic aneurysms using ensemble based deep learning techniques that utilize numerous computed tomography (CT) scans collected from numerous de-identified patients in a database. The system includes software that automates the analysis of a series of CT scans as input (in DICOM file format) and provides output in two dimensions: (1) ranking CT scans by risks of adverse events from aortic aneurysm, (2) providing aortic aneurysm size estimates. A repository of CT scans may be used for training of deep neural networks and additional data may be drawn from localized patient information from institutions and hospitals which grant permission.

IPC Classes  ?

  • G06T 7/00 - Image analysis
  • G06V 10/22 - Image preprocessing by selection of a specific region containing or referencing a patternLocating or processing of specific regions to guide the detection or recognition
  • G06T 17/00 - 3D modelling for computer graphics
  • G06K 9/62 - Methods or arrangements for recognition using electronic means
  • G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
  • G06T 5/50 - Image enhancement or restoration using two or more images, e.g. averaging or subtraction
  • G06T 7/60 - Analysis of geometric attributes
  • G06T 7/11 - Region-based segmentation
  • G06T 3/40 - Scaling of whole images or parts thereof, e.g. expanding or contracting
  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
  • A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • G06T 5/00 - Image enhancement or restoration
  • A61B 6/03 - Computed tomography [CT]

55.

METHODS AND APPARATUSES FOR FORMING PATTERNED FIBER ARRAYS WITH AUTOMATED TRACKS

      
Document Number 03226544
Status Pending
Filing Date 2022-06-13
Open to Public Date 2022-12-22
Owner ROWAN UNIVERSITY (USA)
Inventor
  • Jao, Dave
  • Beachley, Vince

Abstract

In one aspect, the present disclosure provides processes and systems for producing multiple fibers simultaneously, or nearly simultaneously.

IPC Classes  ?

  • D01D 5/098 - Melt-spinning methods with simultaneous stretching
  • D01D 5/16 - Stretch-spinning methods using rollers, or like mechanical devices, e.g. snubbing pins
  • D01D 5/38 - Formation of filaments, threads, or the like during polymerisation
  • D01D 10/04 - Supporting filaments or the like during their treatment

56.

DEVICE PROVIDING NEUROTHERAPEUTIC INTERVENTION VIA MULTI-MODAL ENERGY THERAPY

      
Application Number 17830888
Status Pending
Filing Date 2022-06-02
First Publication Date 2022-12-22
Owner Rowan University (USA)
Inventor Mcglynn, Charles D.

Abstract

The present invention relates generally to a device for providing multi-modal energy therapy to treat neurogenerative disorders, and more particularly to a device providing multi-modal neuro-supportive energy therapy to a person via a daily session in a single facility. The device provides safe, well studied energy therapies in a controlled manner to stimulate neuronal mitochondrial activity which powers the brains neurons and is often defective in neurodegenerative disease states. Selected energy delivery mechanisms and frequencies are employed to stabilize microglial activity and promote microglial homeostasis and neuroprotective secretions, including mitochondrial melatonin and other neuroprotective factors. In addition to practicality, the combination of these proven therapeutic modalities into a single device may offer synergies not found when they are employed alone. This focused combination of these unique energy based therapies may offer new hope to slow, stop, reverse or mitigate neurogenerative disorders, such as Alzheimer's, ALS and Parkinson's diseases.

IPC Classes  ?

  • A61N 2/00 - Magnetotherapy
  • A61N 5/06 - Radiation therapy using light
  • A61H 23/02 - Percussion or vibration massage, e.g. using supersonic vibrationSuction-vibration massageMassage with moving diaphragms with electric or magnetic drive

57.

METHODS AND APPARATUSES FOR FORMING PATTERNED FIBER ARRAYS WITH AUTOMATED TRACKS

      
Application Number 17838948
Status Pending
Filing Date 2022-06-13
First Publication Date 2022-12-22
Owner Rowan University (USA)
Inventor
  • Jao, Dave
  • Beachley, Vince

Abstract

In one aspect, the present disclosure provides processes and systems for producing multiple fibers simultaneously, or nearly simultaneously.

IPC Classes  ?

  • D01D 4/02 - Spinnerettes
  • D01D 4/06 - Distributing spinning solution or melt to spinning nozzles

58.

METHODS AND APPARATUSES FOR FORMING PATTERNED FIBER ARRAYS WITH AUTOMATED TRACKS

      
Application Number US2022033234
Publication Number 2022/265981
Status In Force
Filing Date 2022-06-13
Publication Date 2022-12-22
Owner ROWAN UNIVERSITY (USA)
Inventor
  • Jao, Dave
  • Beachley, Vince

Abstract

In one aspect, the present disclosure provides processes and systems for producing multiple fibers simultaneously, or nearly simultaneously.

IPC Classes  ?

  • D01D 10/04 - Supporting filaments or the like during their treatment
  • D01D 5/38 - Formation of filaments, threads, or the like during polymerisation
  • D01D 5/098 - Melt-spinning methods with simultaneous stretching
  • D01D 5/16 - Stretch-spinning methods using rollers, or like mechanical devices, e.g. snubbing pins

59.

Methods for detecting multiple sclerosis (MS) diagnostic autoantibodies

      
Application Number 17820803
Grant Number 12174187
Status In Force
Filing Date 2022-08-18
First Publication Date 2022-12-08
Grant Date 2024-12-24
Owner Rowan University (USA)
Inventor Nagele, Robert G.

Abstract

Methods for detecting Multiple Sclerosis (MS) diagnostic autoantibodies in a subject and generating a subject-specific, MS diagnostic autoantibody profile are described. The methods include contacting an immunoglobulin-containing biological sample from the subject with a system comprising antigens that form immunocomplexes with MS diagnostic autoantibodies, the antigens including general transcription factor II-I, splicing factor 1, and inducible T-cell co-stimulator (ICOS), to form a reaction mixture, under conditions that allow for formation in the reaction mixture of an immunocomplex between each antigen and its corresponding MS diagnostic autoantibody, if its corresponding MS diagnostic autoantibody is present in the sample; and detecting presence or absence of immunocomplexes in the reaction mixture, wherein formation of immunocomplexes between the antigens and their corresponding MS diagnostic autoantibodies indicates presence of the MS diagnostic autoantibodies in the biological sample.

IPC Classes  ?

  • G01N 33/564 - ImmunoassayBiospecific binding assayMaterials therefor for pre-existing immune complex or autoimmune disease
  • G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
  • G01N 33/552 - Glass or silica

60.

DIAGNOSTIC BIOMARKERS FOR DETECTING, SUBTYPING, AND/OR ASSESSING PROGRESSION OF MULTIPLE SCLEROSIS

      
Application Number 17820815
Status Pending
Filing Date 2022-08-18
First Publication Date 2022-12-08
Owner Rowan University (USA)
Inventor Nagele, Robert G.

Abstract

Disclosed are methods, compositions and kits for detecting Multiple Sclerosis (MS) as well as for distinguishing relapsing-remitting (RRMS) and secondary progressive (SPMS) MS subtypes with high overall accuracy. Autoantibody antigens and biomarkers, for the diagnosis of MS in general, RRMS and SPMS, as well as for the identification of a subject at risk for developing MS, and for the generation of patient-specific MS autoantibody biomarker profiles are also provided.

IPC Classes  ?

  • G01N 33/564 - ImmunoassayBiospecific binding assayMaterials therefor for pre-existing immune complex or autoimmune disease
  • G01N 33/552 - Glass or silica
  • G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor

61.

SYNTHETIC ALIGNED TISSUE GRAFTS AND METHODS OF USING SAME

      
Application Number US2022031429
Publication Number 2022/251694
Status In Force
Filing Date 2022-05-27
Publication Date 2022-12-01
Owner ROWAN UNIVERSITY (USA)
Inventor
  • Beachley, Vince
  • Vega, Sebastian L.
  • Jao, Dave

Abstract

The present disclosure relates to a multi-layer composite comprising at least a first sheet and a second sheet of aligned nanofibers coated with a biodegradable hydrogel, wherein the at least first and second sheets of aligned coated nanofibers are stacked directly on top of each other and a portion of the biodegradable hydrogel coating on the first sheet is mixed and crosslinked with a portion of the biodegradable hydrogel coating on the second sheet. In another aspect, the present disclosure relates to a method of regenerating an aligned soft tissue in a subject, the method comprising surgically implanting a synthetic tissue graft comprising the multi-layer composite in the subject at a site of missing or injured tissue. In yet another aspect, the present disclosure relates to a synthetic nerve graft comprising the multi-layer composite.

IPC Classes  ?

  • A61L 27/00 - Materials for prostheses or for coating prostheses
  • A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
  • A61K 35/12 - Materials from mammalsCompositions comprising non-specified tissues or cellsCompositions comprising non-embryonic stem cellsGenetically modified cells
  • A61L 27/50 - Materials characterised by their function or physical properties

62.

SYSTEMS AND METHODS FOR FIBER ZONE-DRAWING AND/OR ZONE-ANNEALING

      
Application Number US2022026179
Publication Number 2022/232046
Status In Force
Filing Date 2022-04-25
Publication Date 2022-11-03
Owner ROWAN UNIVERSITY (USA)
Inventor
  • Flamini, Matthew
  • Beachley, Vince

Abstract

In one aspect, the present disclosure is related to system and method of manufacturing nanomaterials and particularly to system and method for zone-drawing and/or zone-annealing fibers.

IPC Classes  ?

  • B01J 19/12 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor employing electromagnetic waves

63.

BEHAVIOR-BASED ACCESS CONTROL MANAGEMENT FOR APPLICATION SOFTWARE OF COMPUTING DEVICES

      
Application Number 17706114
Status Pending
Filing Date 2022-03-28
First Publication Date 2022-09-29
Owner Rowan University (USA)
Inventor Raiff, Bethany R.

Abstract

A computerized system and method providing a user interface for management of access to software applications and/or other computing device resources to achieve desired behavioral changes by using sensor-based hardware to assess behavioral aspects and selectively grant or deny desired access based on sensor-gathered data in comparison to predetermined behavior goals. In part, the present invention captures an opportunity to use access to desired mobile computing device apps (or other computing resources) as a low-cost, non-monetary incentive for beneficial behavior modification purposes, such as smoking cessation, etc.

IPC Classes  ?

64.

METABOLIC THERAPY FOR OXIDATIVE STRESS IN THE BRAIN THROUGH TARGETED NEURONAL CATABOLISM OF N-ACETYL-ASPARTIC ACID

      
Application Number 17835668
Status Pending
Filing Date 2022-06-08
First Publication Date 2022-09-29
Owner ROWAN UNIVERSITY (USA)
Inventor
  • Leone, Paola
  • Francis, Jeremy

Abstract

The present invention provides a novel method of treatment for treating brain disorders that manifest oxidative stress by providing targeted populations of neurons with the ability to catabolize the acetylated amino acid derivative, N-acetylaspatic acid (NAA) and further supply extraphysiological levels of ATP to neurons via the targeted expression of the NAA catabolic enzyme aspartoacylase (ASPA) in neurons and astrocytes.

IPC Classes  ?

  • A61K 38/50 - Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
  • C12N 15/86 - Viral vectors
  • A61K 38/52 - Isomerases (5)
  • A61K 35/30 - NervesBrainEyesCorneal cellsCerebrospinal fluidNeuronal stem cellsNeuronal precursor cellsGlial cellsOligodendrocytesSchwann cellsAstrogliaAstrocytesChoroid plexusSpinal cord tissue

65.

Method for detecting radiological progression in cancer surveillance

      
Application Number 17600703
Grant Number 12198334
Status In Force
Filing Date 2020-04-01
First Publication Date 2022-06-02
Grant Date 2025-01-14
Owner
  • The UAB Research Foundation (USA)
  • Rowan University (USA)
Inventor
  • Fathallah-Shaykh, Hassan
  • Bouaynaya, Nidhal

Abstract

A method and computer-based system is provided that assists physicians in detecting early tumor growth and allowing modification of treatment to have a positive impact on medical management, patient morbidity, outcomes and survival times. The method comprises measuring tumor volumes from radiological images to predict growth by a statistical method. The methods allow detection of increases in tumor size earlier than is currently possible and, therefore, advantageous in modifying or optimizing treatment.

IPC Classes  ?

  • G06T 7/00 - Image analysis
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume
  • G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment

66.

SYSTEM AND METHOD FOR THE EXTRACTION OF ISOFLAVONES FROM SOYBEANS

      
Application Number US2021059704
Publication Number 2022/109011
Status In Force
Filing Date 2021-11-17
Publication Date 2022-05-27
Owner ROWAN UNIVERSITY (USA)
Inventor
  • Chea, John, D.
  • Stanzione, Iii, Joseph, F., Iii
  • Yenkie, Kirti M.

Abstract

The present disclosure describes a system for the commercial scale extraction of isoflavones from soybean meal. The system includes an optional grinder, an extraction component, a solid-liquid separation component, an acid hydrolysis component, a neutralization component, and a purification component. Also provided are methods of commercial scale extraction of one or more isoflavones from soybean meal. The method includes extracting an isoflavone glucoside from soybean meal, hydrolyzing the isoflavone glucoside to obtain an isoflavone aglycone, neutralizing the isoflavone aglycone, and purifying the isoflavone aglycone.

IPC Classes  ?

  • A21D 2/36 - Vegetable material
  • A23C 11/02 - Milk substitutes, e.g. coffee whitener compositions containing at least one non-milk component as source of fats or proteins
  • A23C 11/10 - Milk substitutes, e.g. coffee whitener compositions containing at least one non-milk component as source of fats or proteins containing or not lactose but no other milk components as source of fats, carbohydrates or proteins

67.

HANDHELD PRINTER FOR ENHANCED MIXING AND DELIVERY OF MULTI-COMPONENT POLYMERS/BIOMATERIALS

      
Application Number 17533933
Status Pending
Filing Date 2021-11-23
First Publication Date 2022-05-19
Owner Rowan University (USA)
Inventor Miri Ramsheh, Amir K.

Abstract

A mixing injector for a multi-material printer. The injector defines coaxial passages for passing different material components into a mixing portion. The injector defines at least one opening, in a sidewall of at least one of the coaxial passages, to provide fluid communication between the passages, e.g., before/upstream from a mixing portion. Such openings permit and promote material component flow laterally, transversely to a direction of elongation of the coaxial passages, and transversely to a principal direction of flow of the material components. This is believed to create a degree of turbulence in the flow of the material components that enhances mixing of the material components, and provides for enhanced mixing of the component materials. Accordingly, for example, cross-linking may begin to occur before entering the mixing region. The injector may be structured to provide any desired number of passages and openings to provide a desired degree of mixing.

IPC Classes  ?

  • A61M 5/19 - Syringes having more than one chamber
  • A61M 5/315 - PistonsPiston-rodsGuiding, blocking or restricting the movement of the rodAppliances on the rod for facilitating dosing
  • A61B 17/00 - Surgical instruments, devices or methods

68.

BACTERICIDAL COATING COMPOSITIONS AND METHODS USING SAME

      
Application Number 17507951
Status Pending
Filing Date 2021-10-22
First Publication Date 2022-04-28
Owner ROWAN UNIVERSITY (USA)
Inventor
  • Hettinger, Jeffrey
  • Caputo, Gregory A.
  • Yu, Lei

Abstract

The present disclosure relates in part to coating compositions comprising a bactericidal layer further comprising a bactericidal element and a columnar microstructure, which exerts bactericidal activity toward proximal and distal bacteria within an electrolyte solution (i.e. blood or other bodily fluid). The present disclosure further relates to coating compositions stably adhered to an electrode, which exerts bactericidal activity toward proximal and distal bacteria within an electrolyte solution upon application of an electric potential to the underlying electrode without a loss in efficiency of charge transfer.

IPC Classes  ?

69.

METHODS OF TREATING, AMELIORATING, AND/OR PREVENTING COVID-19 INFECTION AND RELATED INFLAMMATION

      
Application Number US2021055542
Publication Number 2022/086916
Status In Force
Filing Date 2021-10-19
Publication Date 2022-04-28
Owner ROWAN UNIVERSITY (USA)
Inventor
  • Goldberg, Gary S.
  • Leone, Paola

Abstract

The present disclosure relates in part to methods of treating, preventing, and/or ameliorating SARS-CoV-2 infection and/or related inflammatory syndromes by administration of a Maackia amurensis seed lectin (MASL). MASL has a strong affinity for sialic acid modified proteins and may be used as an antiviral agent. This lectin targets the ACE2 receptor, decreases ACE2 expression and glycosylation, suppresses binding of the SARS-CoV-2 spike protein, and decreases expression of inflammatory mediators by oral epithelial cells that cause ARDS in COVID-19 patients.

IPC Classes  ?

  • A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
  • A61K 38/00 - Medicinal preparations containing peptides
  • A61K 36/48 - Fabaceae or Leguminosae (Pea or Legume family)CaesalpiniaceaeMimosaceaePapilionaceae
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • C07K 14/42 - Lectins, e.g. concanavalin, phytohaemagglutinin

70.

RENEWABLE BIO-BASED NON-TOXIC AROMATIC-FURANIC MONOMERS FOR USE IN THERMOSETTING AND THERMOPLASTIC POLYMERS

      
Application Number 17284032
Status Pending
Filing Date 2019-10-10
First Publication Date 2021-12-09
Owner
  • Drexel University (USA)
  • The Government of the United States, as represented by the Secretary of the Army (USA)
  • Rowan University (USA)
Inventor
  • Paquette, Craig Michael
  • La Scala, John Joseph
  • Sadler, Joshua Matthew
  • Palmese, Giuseppe Rafaello
  • Bassett, Alexander William
  • Stanzione, Joseph Francis

Abstract

A composition of matter including two optionally substituted phenol or optionally substituted aniline units separated by a furan spacer has been prepared. In particular, the chemical structure has a novolac bridge between the central furan ring and the two attached optionally substituted phenol and/or optionally substituted aniline units. These compounds can be modified to be used in various polymer resins. This new structure reduces toxicity relative to BPA/F, makes use of renewable chemicals, and produces certain beneficial polymer properties.

IPC Classes  ?

  • C07D 407/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
  • C08F 222/20 - Esters containing oxygen in addition to the carboxy oxygen
  • C08G 59/26 - Di-epoxy compounds heterocyclic
  • C07D 307/42 - Singly bound oxygen atoms

71.

NETWORK TOUGHENING OF ADDITIVELY MANUFACTURED, HIGH GLASS TRANSITION TEMPERATURE MATERIALS VIA SEQUENTIALLY CURED, INTERPENETRATING POLYMERS

      
Application Number US2021018547
Publication Number 2021/230940
Status In Force
Filing Date 2021-02-18
Publication Date 2021-11-18
Owner
  • ROWAN UNIVERSITY (USA)
  • THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (USA)
Inventor
  • La Scala, John J.
  • Bassett, Alexander W.
  • Stanzione, Iii, Joseph F.

Abstract

Resins and formulations of individual monomers bearing both vinyl ester and epoxy functionality were either synthesized or formulated such that vinyl ester components capable of polymerizing by photo-induced, free radical polymerization were mixed with step-growth epoxy-amine systems, facilitating sequential cure. The vinyl ester component was photopolymerized using vat photopolymerization (VPP). Additionally, the preparation of bio-based photo curable thermosetting resins that have tailorable thermal and mechanical properties is provided. All monomers and polymers described herein are useful in a variety of applications, including additive manufacturing applications.

IPC Classes  ?

  • C08F 222/12 - Esters of phenols or saturated alcohols
  • C08F 122/20 - Esters containing oxygen in addition to the carboxy oxygen
  • C07C 57/04 - Acrylic acidMethacrylic acid
  • C07C 69/54 - Acrylic acid estersMethacrylic acid esters
  • A61K 31/78 - Polymers containing oxygen of acrylic acid or derivatives thereof

72.

MULTI-MATERIAL PRINTER DEVICE FOR MANUFACTURE OF HIGH-THROUGHPUT SCREENING MICROFLUIDIC CHIPS

      
Application Number US2021025025
Publication Number 2021/216258
Status In Force
Filing Date 2021-03-31
Publication Date 2021-10-28
Owner ROWAN UNIVERSITY (USA)
Inventor
  • Miri Ramsheh, Amir K.
  • Bhusal, Anant
  • Nguyen, Hai Anh
  • Nieto, Daniel

Abstract

A multi-material printer for using multiple materials, e.g., bioinks, to quickly fabricate structures, such as high-throughput screening microfluidic chips. The printer's light projector for emits light in an exposure sequence to cure material in an additive manufacturing process. The printer further includes a motion stage operable to move a build platform into and out of the reservoir in coordination with the exposure sequence. The printer further includes an indexing stage having a work table for supporting the reservoir. The indexing stage is operable to selectively align the build platform with multiple different materials of the reservoir. The multiple materials may be arranged at distinct angular positions within a single reservoir, and the indexing stage may be operable to rotate the work table to align the build platform with different materials during the exposure sequence for a quick transition among different materials without refilling of materials, exchange of reservoirs, etc.

IPC Classes  ?

  • B29C 64/106 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
  • B29C 64/124 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified
  • B29C 35/08 - Heating or curing, e.g. crosslinking or vulcanising by wave energy or particle radiation
  • B33Y 10/00 - Processes of additive manufacturing
  • B33Y 30/00 - Apparatus for additive manufacturingDetails thereof or accessories therefor

73.

Methods of modifying cellulose crystallinity

      
Application Number 17218372
Grant Number 12018099
Status In Force
Filing Date 2021-03-31
First Publication Date 2021-09-30
Grant Date 2024-06-25
Owner
  • Rutgers, The State University of New Jersey (USA)
  • Rowan University (USA)
Inventor
  • Salas De La Cruz, David
  • Hu, Xiao
  • Love, Stacy
  • Verrill, David

Abstract

The present disclosure provides methods of controlling the size of cellulose crystals by mixing a first composition comprising cellulose and coagulating this mixture with varying concentrations of hydrogen peroxide.

IPC Classes  ?

  • C08B 15/08 - Fractionation of cellulose, e.g. separation of cellulose crystallites
  • B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
  • B01D 71/10 - CelluloseModified cellulose
  • C02F 1/44 - Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis
  • C08K 3/04 - Carbon
  • C08K 11/00 - Use of ingredients of unknown constitution, e.g. undefined reaction products
  • C08L 5/08 - ChitinChondroitin sulfateHyaluronic acidDerivatives thereof
  • C08L 67/04 - Polyesters derived from hydroxy carboxylic acids, e.g. lactones

74.

WEARABLE BODY COMPOSITION ANALYZER

      
Application Number 17261749
Status Pending
Filing Date 2019-10-28
First Publication Date 2021-09-23
Owner Rowan University (USA)
Inventor
  • Gupta, Adarsh K.
  • Usman, Muhammad
  • Xue, Wei

Abstract

A device for analyzing body composition provides improved accuracy in measuring body fat, lean body mass and body water using bio-electrical impedance (BIA) measurement. The includes a ring sized to fit a human finger, and including components for passing current. Electrodes are provided for contacting the ring finger of one hand (on an interior portion of the ring), and for making contact with fingers of the opposing hand (on an exterior portion of the ring), so that BIA of the human body can be measured across the human body between the left and right hands, as the result current and voltage applied by the ring. The ring may include components for performing the BIA analysis, or for communicating data to another device for performing the BIA analysis. Results of the analysis may be displayed at the other device, or via a display supported on the ring.

IPC Classes  ?

  • A61B 5/0537 - Measuring body composition by impedance, e.g. tissue hydration or fat content
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/263 - Bioelectric electrodes therefor characterised by the electrode materials

75.

MOBILE SENSOR-BASED RAILWAY CROSSING SAFETY DEVICE

      
Application Number US2021018468
Publication Number 2021/173406
Status In Force
Filing Date 2021-02-18
Publication Date 2021-09-02
Owner ROWAN UNIVERSITY (USA)
Inventor
  • Mcglynn, Charles D.
  • Zhang, Hong
  • Diorio, Joseph S.

Abstract

A device for detecting an approaching train at a roadway railway crossing and providing an intervention for avoiding a collision that avoids the need for crossing site approval, installations, etc. and associated hardware and installation costs. The device may be configured as a stand-alone device, as an accessory matable to a motor vehicle (e.g., via an OBD II port), or may be fully integrated into the motor vehicle. The device includes a microphone for receiving an ambient audio signal, and processes the audio signal to determine whether a train is present. If so, the device may provide an audible and/or visual warning signal to a vehicle driver, via the device itself or via components of the motor vehicle. In certain other embodiments, the device is configured to provide a control signal causing operation of braking, engine, steering or other vehicle systems to avoid a collision.

IPC Classes  ?

  • B61L 29/00 - Safety means for rail/road crossing traffic
  • B61L 29/30 - Supervision, e.g. monitoring arrangements
  • B61L 29/18 - Operation by approaching rail vehicle or train
  • G08B 21/02 - Alarms for ensuring the safety of persons

76.

Noninvasive three-dimensional fluorescence microscopy for skin disease detection

      
Application Number 17051597
Grant Number 11546572
Status In Force
Filing Date 2019-05-21
First Publication Date 2021-08-05
Grant Date 2023-01-03
Owner Rowan University (USA)
Inventor
  • Wu, Ben
  • Tang, Ying
  • Hu, Xiao

Abstract

Methods and systems for digitally reconstructing a patient tissue sample are described herein. In one embodiment, the method may include projecting a first structured light pattern onto the patient tissue sample, receiving a first reflection of the first structured light pattern from the patient tissue sample, and reconstructing the patient tissue sample based on the first reflection and the projected first structured light pattern. In another embodiment, the system may include a projector adapted or configured to project the first structured light onto the patient tissue sample, a charge-coupled device (CCD) adapted or configured to receive the first reflection from the patient tissue sample, and a reconstruction device adapted or configured to reconstruct the patient tissue sample based on the first reflection and the projected first structured light pattern.

IPC Classes  ?

  • H04N 13/254 - Image signal generators using stereoscopic image cameras in combination with electromagnetic radiation sources for illuminating objects
  • G06T 7/521 - Depth or shape recovery from laser ranging, e.g. using interferometryDepth or shape recovery from the projection of structured light
  • H04N 5/372 - Charge-coupled device [CCD] sensors; Time delay and integration [TDI] registers or shift registers specially adapted for SSIS
  • H04N 13/00 - Stereoscopic video systemsMulti-view video systemsDetails thereof

77.

Serum biomarkers for predicting and evaluating response to TNF inhibitor therapy in rheumatoid arthritis patients

      
Application Number 16093122
Grant Number 11644473
Status In Force
Filing Date 2017-04-14
First Publication Date 2021-07-15
Grant Date 2023-05-09
Owner Rowan University (USA)
Inventor
  • Han, Kwanghoon
  • Bottaro, Andrea
  • Olsen, Nancy J.

Abstract

The present disclosure is directed to methods and kits for using serum biomarkers, including C-X-C Motif Chemokine Ligand 10 (CXCL10), C-X-C Motif Chemokine Ligand 13 (CXCL13), and/or soluble CD27 (sCD27), in predicting and evaluating therapeutic response to Tumor Necrosis Factor (TNF) inhibitor therapy in a patient in need thereof.

IPC Classes  ?

  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
  • C07K 16/24 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons

78.

Methods of Treating or Preventing Amyotrophic Lateral Sclerosis

      
Application Number 17270553
Status Pending
Filing Date 2019-08-30
First Publication Date 2021-06-17
Owner Rowan University (USA)
Inventor
  • Francis, Jeremy
  • Leone, Paola

Abstract

This disclosure provides methods for treating, ameliorating, or reversing at least one symptom of amyotrophic lateral sclerosis (ALS) in a subject by increasing the amount of neuronal aspartate in spinal cord through administration of a therapeutically effective amount of a composition comprising a nucleic acid encoding ASPA or a functional fragment thereof.

IPC Classes  ?

  • A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
  • C12N 15/86 - Viral vectors

79.

NEURON FOUNDRY

      
Serial Number 90766644
Status Pending
Filing Date 2021-06-10
Owner Rowan University ()
NICE Classes  ? 10 - Medical apparatus and instruments

Goods & Services

Electric and electromagnetic apparatus used for therapeutic and medical purposes in the treatment of neurogenerative disorders

80.

NEURON FOUNDRY

      
Serial Number 90764583
Status Pending
Filing Date 2021-06-09
Owner Rowan University ()
NICE Classes  ? 10 - Medical apparatus and instruments

Goods & Services

Electric and electromagnetic apparatus used for therapeutic and medical purposes in the treatment of neurogenerative disorders

81.

Bio-ionic liquid hydrogels and use of same

      
Application Number 17045300
Grant Number 11605508
Status In Force
Filing Date 2019-04-08
First Publication Date 2021-05-20
Grant Date 2023-03-14
Owner Rowan University (USA)
Inventor
  • Noshadi, Iman
  • Krishnadoss, Vaishali

Abstract

The present invention relates in part to a polymer functionalized with a bio-ionic liquid to form a gel electrolyte. The gel electrolyte thus formed is biocompatible and biodegradable. In certain embodiments, the electrolyte is used for making implantable 3D printed energy storage devices.

IPC Classes  ?

  • H01G 11/56 - Solid electrolytes, e.g. gelsAdditives therein
  • H01G 11/36 - Nanostructures, e.g. nanofibres, nanotubes or fullerenes
  • H01G 11/38 - Carbon pastes or blendsBinders or additives therein
  • H01G 11/86 - Processes for the manufacture of hybrid or EDL capacitors, or components thereof specially adapted for electrodes
  • H01G 11/26 - Electrodes characterised by their structure, e.g. multi-layered, porosity or surface features

82.

Method of producing non-woven protein fibers

      
Application Number 16605848
Grant Number 11549198
Status In Force
Filing Date 2018-04-17
First Publication Date 2021-04-29
Grant Date 2023-01-10
Owner Rowan University (USA)
Inventor
  • Hu, Xiao
  • Mou, Xiaoyang

Abstract

The invention relates to non-woven protein fibers and to methods for forming and producing the same. In certain embodiments, the invention provides a method of processing a protein comprising dissolving a protein in a solution, optionally removing any insoluble materials from the solution, and spraying the solution under an applied pressure. In other embodiments, the protein can be derived from a range of sources, including but not limited to arthropod silks, animal keratin (e.g. hair and wool), tissue elastin, collagen, resilin, and plant protein. In certain embodiments, the methods of the invention are an alternative to electrospinning methods known in the art.

IPC Classes  ?

  • B29C 41/08 - Coating a former, core or other substrate by spraying or fluidisation, e.g. spraying powder
  • B29C 41/24 - Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped articleApparatus therefor for making articles of indefinite length
  • B29C 41/28 - Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped articleApparatus therefor for making articles of indefinite length by depositing flowable material on an endless belt
  • B29C 41/46 - Heating or cooling
  • D01D 1/02 - Preparation of spinning solutions
  • D01D 10/06 - Washing or drying
  • D01D 5/14 - Stretch-spinning methods with flowing liquid stretching media
  • D01D 5/26 - Formation of staple fibres
  • D01F 1/10 - Other agents for modifying properties
  • D01F 4/00 - Monocomponent artificial filaments or the like of proteinsManufacture thereof

83.

HANDHELD PRINTER FOR CONTROLLED MIXING AND DELIVERY OF MULTI-COMPONENT POLYMERS/BIOMATERIALS

      
Application Number 17073506
Status Pending
Filing Date 2020-10-19
First Publication Date 2021-04-29
Owner Rowan University (USA)
Inventor
  • Miri Ramsheh, Amir K.
  • Malpica, Matthew William

Abstract

Compact, light-weight, handheld printer devices are capable of delivering multi-part materials in mixed form, with controllable dwell-time within the device to allow for a desired amount of physical mixing and chemical cross-linking, while also allowing for deposition of the material directly onto a deposition site. A pen-style printer having a slim but elongated form factor is particularly suitable for depositing biomaterials directly onto a surgical site in the throat. The device may be configured to receive and dispense materials directly from conventional syringes. The printer device may be configured for dispensing and mixing materials having two or more component parts, and may include a leadscrew mechanism providing mechanical advantage, for dispensing higher-viscosity materials, and/or an enhanced degree of precision in dispensing a quantity of material. The mixing time and quantities can be controlled by varying one or more of syringe size and/or injector passage size and mixing chamber length.

IPC Classes  ?

  • A61M 5/315 - PistonsPiston-rodsGuiding, blocking or restricting the movement of the rodAppliances on the rod for facilitating dosing
  • B29C 48/02 - Small extruding apparatus, e.g. handheld, toy or laboratory extruders
  • A61M 5/31 - Syringes Details

84.

IN SITU CUT AND PASTE (ICAP)

      
Application Number US2020056453
Publication Number 2021/080962
Status In Force
Filing Date 2020-10-20
Publication Date 2021-04-29
Owner ROWAN UNIVERSITY (USA)
Inventor
  • Jiang, Ping
  • Kemper, Kevin, M.
  • Caradonna, Salvatore, J.

Abstract

The present invention relates to innovative means of DNA sequence editing involving in-situ cut-and-paste (iCAP) or alternatively cut-and-paste in-situ (CAPi). Thus, in various embodiments described herein, the methods of the invention relate to methods of generating paired-end nucleic acid fragment sharing common linker nucleic acid sequences using a nicking endonuclease, a T7 endonuclease, a restriction enzyme or a transposase, methods of analyzing the nucleotides sequences from the linked-paired-end sequenced fragments and methods of de novo whole genome mapping.

IPC Classes  ?

  • C12N 9/22 - Ribonucleases
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C12N 15/90 - Stable introduction of foreign DNA into chromosome

85.

METHOD FOR UNCERTAINTY ESTIMATION IN DEEP NEURAL NETWORKS

      
Application Number US2020053441
Publication Number 2021/071711
Status In Force
Filing Date 2020-09-30
Publication Date 2021-04-15
Owner
  • THE UAB RESEARCH FOUNDATION (USA)
  • ROWAN UNIVERSITY (USA)
Inventor
  • Fathallah-Shaykh, Hassan
  • Bouaynaya, Nidhal
  • Rasool, Ghulam
  • Dera, Dimah

Abstract

Disclosed are various approaches for estimating uncertainty in deep neural networks. A respective tensor normal distribution can be applied to each of a plurality of convolutional kernels of a convolutional neural network, wherein the respective tensor normal distribution captures a correlation and a variance heteorgeneity of each of the plurality of convolutional kernels. Then, the mean and covariance of each respective tensor normal distribution passing through the non-linear activation function of each nonlinear perceptron can be approximated. Next, a max-pool operation can be performed on a plurality of outputs of the plurality of non-linear perceptrons to generate an output tensor. Then, the output tensor can be vectorized to create an input vector for a fully-connected layer of the convolutional neural network. Subsequently, an output vector can be generated using the fully-connected layer. Then, a mean matrix and a covariance matrix for the output vector can be computed.

IPC Classes  ?

  • G06F 15/00 - Digital computers in generalData processing equipment in general
  • G06N 3/08 - Learning methods
  • G10L 15/16 - Speech classification or search using artificial neural networks
  • H03F 1/26 - Modifications of amplifiers to reduce influence of noise generated by amplifying elements

86.

Systems and methods for data collection and performance monitoring of transportation infrastructure

      
Application Number 16643999
Grant Number 11538256
Status In Force
Filing Date 2018-09-12
First Publication Date 2021-03-04
Grant Date 2022-12-27
Owner Rowan University (USA)
Inventor
  • Bhavsar, Parth
  • Bouaynaya, Nidhal
  • Mehta, Yusuf
  • Chowdhury, Mashrur

Abstract

The present invention provides a data collection system comprising: a camera; a location module; a plurality of sensors; and a first processor communicatively coupled to the camera and the location module, the first processor programmed to: obtain a plurality of frames from the camera; obtain a plurality of locations from the location module; obtain a plurality of data measurements from the plurality of sensors; apply a previously trained first neural network model for identifying problematic road segments to frames captured by the camera; and if the first neural network model indicates that a frame is a problematic road segment, save the frame in association with a location provided by the location module.

IPC Classes  ?

  • G06V 20/58 - Recognition of moving objects or obstacles, e.g. vehicles or pedestriansRecognition of traffic objects, e.g. traffic signs, traffic lights or roads
  • G06K 9/62 - Methods or arrangements for recognition using electronic means
  • G06N 3/02 - Neural networks
  • G06V 20/56 - Context or environment of the image exterior to a vehicle by using sensors mounted on the vehicle
  • G06T 7/00 - Image analysis
  • G06V 20/40 - ScenesScene-specific elements in video content

87.

POLY (IONIC LIQUID) COMPOSITIONS AND THEIR USE AS TISSUE ADHESIVES

      
Application Number 17044591
Status Pending
Filing Date 2019-04-02
First Publication Date 2021-01-28
Owner ROWAN UNIVERSITY (USA)
Inventor Noshadi, Iman

Abstract

The present invention relates to the discovery of methods of treating a wound in a subject in need thereof. In certain embodiments, the method comprises contacting the wound with a composition comprising gelatin methacrylate and choline acrylate, and then polymerizing the composition to form a polymerized composition having a plurality of choline acrylate functionalized gelatin methacrylate units.

IPC Classes  ?

  • A61L 24/04 - Surgical adhesives or cementsAdhesives for colostomy devices containing macromolecular materials
  • A61L 24/00 - Surgical adhesives or cementsAdhesives for colostomy devices
  • A61B 17/00 - Surgical instruments, devices or methods

88.

METHODS FOR DETECTING POSITIONAL MOVEMENT OF ORTHOPEDIC IMPLANTS

      
Application Number 16966613
Status Pending
Filing Date 2019-02-13
First Publication Date 2021-01-28
Owner ROWAN UNIVERSITY (USA)
Inventor
  • Brewer, Erik
  • Dietrich, Hanna
  • Difranceisco, Joseph
  • Diguglielmo, Ann
  • Isaga, Miguel
  • Austin, Luke
  • Seyyedhosseinzadeh, Hamid
  • Staehle, Mary

Abstract

Methods for detecting positional movement of orthopedic implants are described herein. In one embodiment, the method may include receiving a two-dimensional image defining an image plane, the two-dimensional image capturing a reference marker received within the bone and an orthopedic implant received within a bone, calculating a first angle of the reference marker relative to the image plane based on previously stored dimensions of the reference marker, calculating a second angle of the orthopedic implant relative to the image plane based on previously stored dimensions of the orthopedic implant, comparing the first angle to the second angle to calculate a current angle of rotation, and comparing the current angle of rotation to a previously calculated angle of rotation to detect rotation of the orthopedic implant relative to the bone.

IPC Classes  ?

  • A61B 6/12 - Arrangements for detecting or locating foreign bodies
  • A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
  • A61F 2/32 - Joints for the hip
  • A61F 2/36 - Femoral heads
  • A61F 2/38 - Joints for elbows or knees
  • A61F 2/40 - Joints for shoulders
  • A61F 2/42 - Joints for wrists or anklesJoints for hands, e.g. fingersJoints for feet, e.g. toes

89.

AUTOMATED DETECTION OF COGNITIVE CONDITIONS

      
Application Number 16970528
Status Pending
Filing Date 2019-03-01
First Publication Date 2020-12-31
Owner ROWAN UNIVERSITY (USA)
Inventor
  • Libon, David J.
  • Baliga, Ganesh
  • Kerwin, Mary Louise E.
  • Swenson, Rodney A.

Abstract

A computer-implemented method for diagnosing a neurological or medical condition of a patient is described herein. In one embodiment, the computer-implemented method may include presenting a set of values via a graphical user interface or an audio speaker, receiving at least a first response from the patient based on the presented set of values, determining at least one time lapse between presenting the set of values and receiving the at least first response, and identifying the neurological or medical condition of the patient based on the at least one time lapse.

IPC Classes  ?

  • A61B 5/16 - Devices for psychotechnicsTesting reaction times
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
  • G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation

90.

Biocompatible oxygen gas generating devices for tissue engineering

      
Application Number 16869751
Grant Number 11389583
Status In Force
Filing Date 2020-05-08
First Publication Date 2020-11-12
Grant Date 2022-07-19
Owner Rowan University (USA)
Inventor Noshadi, Iman

Abstract

The present invention relates to novel biocompatible oxygen gas generating devices that can be implanted into a living subject. In certain embodiments, the oxygen gas generating devices can be used to deliver oxygen gas to tissue in a subject, thereby stimulating tissue growth and repair. In other embodiments, the devices operate by electrolytically splitting endogenous water in a subject. In yet other embodiments, the device further comprises an implantable supercapacitor capable of supplying energy to the oxygen gas generating device.

IPC Classes  ?

  • A61L 27/52 - Hydrogels or hydrocolloids
  • A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests
  • A61L 31/14 - Materials characterised by their function or physical properties
  • A61L 27/38 - Animal cells
  • H01M 4/58 - Selection of substances as active materials, active masses, active liquids of inorganic compounds other than oxides or hydroxides, e.g. sulfides, selenides, tellurides, halogenides or LiCoFySelection of substances as active materials, active masses, active liquids of polyanionic structures, e.g. phosphates, silicates or borates
  • H01M 4/583 - Carbonaceous material, e.g. graphite-intercalation compounds or CFx
  • A61L 27/58 - Materials at least partially resorbable by the body
  • A61M 1/16 - Dialysis systemsArtificial kidneysBlood oxygenators with membranes
  • C25B 1/02 - Hydrogen or oxygen
  • C25B 11/04 - ElectrodesManufacture thereof not otherwise provided for characterised by the material
  • H01G 9/004 - Electrolytic capacitors, rectifiers, detectors, switching devices, light-sensitive or temperature-sensitive devicesProcesses of their manufacture Details
  • C25B 9/17 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof
  • H01M 4/02 - Electrodes composed of, or comprising, active material

91.

Early-stage Alzheimer's disease autoantibody biomarkers, target antigens and diagnostic uses thereof

      
Application Number 16061534
Grant Number 11619632
Status In Force
Filing Date 2016-12-14
First Publication Date 2020-10-29
Grant Date 2023-04-04
Owner Rowan University (USA)
Inventor Nagele, Robert G.

Abstract

The present invention provides methods, compositions, and kits for the detection of Early-Stage Alzheimer's disease (AD) autoantibody biomarkers, for the diagnosis of Early-Stage AD, for the identification of a subject at risk for developing Early-Stage AD, and/or for the generation of patient-specific Early-Stage AD autoantibody biomarker profiles.

IPC Classes  ?

  • G01N 33/564 - ImmunoassayBiospecific binding assayMaterials therefor for pre-existing immune complex or autoimmune disease
  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

92.

Inflatable impact shield system

      
Application Number 16762037
Grant Number 11555326
Status In Force
Filing Date 2019-01-04
First Publication Date 2020-10-29
Grant Date 2023-01-17
Owner Rowan University (USA)
Inventor
  • Mcglynn, Charles D.
  • Zhu, Cheng

Abstract

An impact shield for earthquake protection is described herein. The impact shield may include a canopy constructed of a puncture-resistant material, the canopy defining a first internal volume accessible via a first opening, the canopy being structured to form a semispherical shape when in an inflated state, the semispherical shape defining a space dimensioned for sheltering at least one human body; a support joined to the canopy and constructed of the puncture-resistant material, the support defining a second internal volume accessible via the first opening and a second opening, the support located within the space, the support structured to form a column when in the inflated state; and a fitting joined to the support for closing the second opening to fix the first internal volume and the second internal volume after inflation of the support and the canopy.

IPC Classes  ?

  • E04H 9/02 - Buildings, groups of buildings or shelters adapted to withstand or provide protection against abnormal external influences, e.g. war-like action, earthquake or extreme climate withstanding earthquake or sinking of ground
  • E04H 15/20 - Tents or canopies, in general inflatable, e.g. shaped, strengthened or supported by fluid pressure
  • E04H 15/26 - Center-pole supported tents
  • E04H 15/36 - Supporting means, e.g. frames arch-shaped type
  • E04H 9/16 - Buildings, groups of buildings or shelters adapted to withstand or provide protection against abnormal external influences, e.g. war-like action, earthquake or extreme climate against adverse conditions, e.g. extreme climate, pests
  • E04H 9/10 - Independent sheltersArrangement of independent splinter-proof walls
  • E04H 9/14 - Buildings, groups of buildings or shelters adapted to withstand or provide protection against abnormal external influences, e.g. war-like action, earthquake or extreme climate against other dangerous influences, e.g. tornadoes, floods
  • F41H 5/24 - ArmourArmour platesShields for stationary use, e.g. fortifications
  • F41H 5/08 - Shields for personal use

93.

METHOD FOR DETECTING RADIOLOGICAL PROGRESSION IN CANCER SURVEILLANCE

      
Application Number US2020026113
Publication Number 2020/205931
Status In Force
Filing Date 2020-04-01
Publication Date 2020-10-08
Owner
  • THE UAB RESEARCH FOUNDATION (USA)
  • ROWAN UNIVERSITY (USA)
Inventor
  • Fathallah-Shaykh, Hassan
  • Bouaynaya, Nidhal

Abstract

A method and computer-based system is provided that assists physicians in detecting early tumor growth and allowing modification of treatment to have a positive impact on medical management, patient morbidity, outcomes and survival times. The method comprises measuring tumor volumes from radiological images to predict growth by a statistical method. The methods allow detection of increases in tumor size earlier than is currently possible and, therefore, advantageous in modifying or optimizing treatment.

IPC Classes  ?

  • A61B 5/103 - Measuring devices for testing the shape, pattern, size or movement of the body or parts thereof, for diagnostic purposes
  • A61B 5/066 -
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • G06T 7/00 - Image analysis

94.

Compositions and methods for treating or ameliorating cocaine addiction

      
Application Number 16804815
Grant Number 11471496
Status In Force
Filing Date 2020-02-28
First Publication Date 2020-09-03
Grant Date 2022-10-18
Owner
  • Rowan University (USA)
  • The Regents of the University of Colorado (USA)
Inventor
  • Keck, Thomas M.
  • Lowry, Christopher A.

Abstract

M. vaccae immunization reduces addiction- and relapse-like responding in models of cocaine addiction and alter the development of cocaine-induced neuroinflammation.

IPC Classes  ?

  • A61K 35/74 - Bacteria
  • A61P 25/30 - Drugs for disorders of the nervous system for treating abuse or dependence

95.

Surgical robot

      
Application Number 16832141
Grant Number 11389256
Status In Force
Filing Date 2020-03-27
First Publication Date 2020-08-06
Grant Date 2022-07-19
Owner Rowan University (USA)
Inventor Abedin-Nasab, Mohammad

Abstract

A surgical robot includes a fixed frame and a moving frame, each having an open space in a center region and may be formed as a partially open ring. The robot also includes three leg structures connecting the fixed frame and the moving frame, and enabling the moving frame to move relative to the fixed frame. The robot also includes a stabilizer for holding an anatomical structure in the open space of each frame. Each leg structure may include a linear component coupled to the moving frame, a rotary component mounted to the fixed frame, and a connector connecting between the two. Each of the linear component and the rotary component may have a rotary actuator that can be controlled by a computer. The robot may be controllable by a computer to assist a reduction procedure of long bone fractures or pelvis surgery.

IPC Classes  ?

  • A61B 34/30 - Surgical robots
  • A61B 34/00 - Computer-aided surgeryManipulators or robots specially adapted for use in surgery
  • A61B 17/62 - Ring frames, i.e. devices extending around the bones to be positioned
  • A61B 90/50 - Supports for surgical instruments, e.g. articulated arms
  • A61B 17/00 - Surgical instruments, devices or methods
  • A61B 17/88 - Methods or means for implanting or extracting internal fixation devices
  • A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
  • A61B 90/57 - Accessory clamps
  • A61B 17/56 - Surgical instruments or methods for treatment of bones or jointsDevices specially adapted therefor

96.

Methods utilizing D-dimer for diagnosis of periprosthetic joint infection

      
Application Number 16080416
Grant Number 11226342
Status In Force
Filing Date 2017-03-01
First Publication Date 2020-07-16
Grant Date 2022-01-18
Owner Rowan University (USA)
Inventor
  • Shahi, Alisina
  • Parvizi, Javad

Abstract

This invention relates to the detection and quantification of D-dimer levels in a sample derived from a patient having or suspected of having periprosthetic joint infection (PJI) and subsequent diagnosis of PJI.

IPC Classes  ?

  • G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

97.

Bio-based, multi-aromatic compounds, and methods of making and using same

      
Application Number 16613857
Grant Number 11008297
Status In Force
Filing Date 2018-05-15
First Publication Date 2020-06-25
Grant Date 2021-05-18
Owner
  • Rowan University (USA)
  • The United States of America as Represented by the Secretary of the Army (USA)
Inventor
  • Bassett, Alexander W.
  • Stanzione, Iii, Joseph F.
  • La Scala, John J.
  • Sadler, Joshua M.
  • Stecca, Owen M.

Abstract

The present invention relates to the unexpected discovery of novel multi-aromatic, multi-substituted compounds. In certain embodiments, the compounds of the invention are generated by condensing at least two phenolic- and/or aniline-containing monomers and an aromatic, aliphatic or heteroaromatic aldehyde- and/or ketone-containing monomer. In other embodiments, at least one monomer is isolated from a bio-based resource. In yet other embodiments, the compounds of the invention are bis- or poly-phenolic compounds.

IPC Classes  ?

  • C07D 307/42 - Singly bound oxygen atoms
  • C07D 407/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
  • C07C 43/23 - Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
  • C07C 69/54 - Acrylic acid estersMethacrylic acid esters

98.

Metabolic therapy for oxidative stress in the brain through targeted neuronal catabolism of N-acetyl-aspartic acid

      
Application Number 16508870
Grant Number 11382961
Status In Force
Filing Date 2019-07-11
First Publication Date 2020-06-04
Grant Date 2022-07-12
Owner ROWAN UNIVERSITY (USA)
Inventor
  • Leone, Paola
  • Francis, Jeremy

Abstract

The present invention provides a novel method of treatment for treating brain disorders that manifest oxidative stress by providing targeted populations of neurons with the ability to catabolize the acetylated amino acid derivative, N-acetylaspatic acid (NAA) and further supply extraphysiological levels of ATP to neurons via the targeted expression of the NAA catabolic enzyme aspartoacylase (ASPA) in neurons and astrocytes.

IPC Classes  ?

  • A61K 38/50 - Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
  • A61K 35/30 - NervesBrainEyesCorneal cellsCerebrospinal fluidNeuronal stem cellsNeuronal precursor cellsGlial cellsOligodendrocytesSchwann cellsAstrogliaAstrocytesChoroid plexusSpinal cord tissue
  • A61K 38/52 - Isomerases (5)
  • C12N 15/86 - Viral vectors

99.

WEARABLE BODY COMPOSITION ANALYZER

      
Application Number US2019058334
Publication Number 2020/092230
Status In Force
Filing Date 2019-10-28
Publication Date 2020-05-07
Owner ROWAN UNIVERSITY (USA)
Inventor
  • Gupta, Adarsh K.
  • Usman, Muhammad
  • Xue, Wei

Abstract

A device for analyzing body composition provides improved accuracy in measuring body fat, lean body mass and body water using bio-electrical impedance (BIA) measurement. The includes a ring sized to fit a human finger, and including components for passing current. Electrodes are provided for contacting the ring finger of one hand (on an interior portion of the ring), and for making contact with fingers of the opposing hand (on an exterior portion of the ring), so that BIA of the human body can be measured across the human body between the left and right hands, as the result current and voltage applied by the ring. The ring may include components for performing the BIA analysis, or for communicating data to another device for performing the BIA analysis. Results of the analysis may be displayed at the other device, or via a display supported on the ring.

IPC Classes  ?

  • A61B 5/053 - Measuring electrical impedance or conductance of a portion of the body
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/05 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves
  • A61B 5/48 -

100.

METHODS OF TREATING OR PREVENTING AMYOTROPHIC LATERAL SCLEROSIS

      
Document Number 03107612
Status Pending
Filing Date 2019-08-30
Open to Public Date 2020-03-05
Owner ROWAN UNIVERSITY (USA)
Inventor
  • Francis, Jeremy
  • Leone, Paola

Abstract

This disclosure provides methods for treating, ameliorating, or reversing at least one symptom of amyotrophic lateral sclerosis (ALS) in a subject by increasing the amount of neuronal aspartate in spinal cord through administration of a therapeutically effective amount of a composition comprising a nucleic acid encoding ASPA or a functional fragment thereof.

IPC Classes  ?

  • A61K 38/50 - Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
  • A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
  • A61P 25/00 - Drugs for disorders of the nervous system
  • C12N 15/86 - Viral vectors
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