Abstract

A system and method are provided for identifying breath variability events from patient respiratory data obtained during the operation of a mechanical ventilator. The ventilator monitors and saves patient respiratory data during operation. The method includes extracting treatment parameters from a ventilation prescription, and using the treatment parameters to determine an Epoch size and a frequency band for analysis. An input signal (flow or pressure) is extracted from the patient data and from the input signal at least one parameter is extracted and analyzed. A Spectral Energy (Es) of the input signal is determined based on the signal parameter, an Epoch size and a frequency band and a Spectral Entropy (SE) is determined based on the Spectral Energy (Es). The Spectral Entropy may then be displayed in graphical form to identify breath variability events over the Epoch size. The method may further classify the type and degree of the events.

IPC Classes  ?

• A61B 5/08 - Measuring devices for evaluating the respiratory organs
• A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes

Abstract

A system and method are provided for identifying breath variability events from patient respiratory data obtained during the operation of a mechanical ventilator (10). The ventilator monitors and saves patient respiratory data during operation. The method includes extracting treatment parameters from a ventilation prescription, and using the treatment parameters to determine an Epoch size and a frequency band for analysis. An input signal (flow or pressure) is extracted from the patient data and from the input signal at least one parameter is extracted and analyzed. A Spectral Energy (Es) of the input signal is determined based on the signal parameter, an Epoch size and a frequency band and a Spectral Entropy (SE) is determined based on the Spectral Energy (Es). The Spectral Entropy may then be displayed in graphical form to identify breath variability events over the Epoch size. The method may further classify the type and degree of the events.

IPC Classes  ?

• A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes
• A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• A61B 5/08 - Measuring devices for evaluating the respiratory organs
• A61B 5/087 - Measuring breath flow
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

A system and method are provided for dynamically controlling the operation of a mechanical ventilator. A saved prescription includes a base or therapeutic ventilation configuration, intervention logic for identifying an intervention entrance condition, and an intervention configuration. The ventilator system initially operates in the base configuration, continuously monitors readings from patient biometric sensors, continuously determines, according to the intervention logic and the monitored readings, if an intervention entrance condition is present. If the entrance condition is present, the system dynamically reconfigures into the intervention configuration. Intervention exit conditions are also programmed wherein during operation in the intervention configuration, the method continuously monitors readings from the biometric sensors, determines, according to the intervention logic and the monitored readings, if an intervention exit condition is present, and if exit conditions are present, reconfigures the ventilator system into the base configuration.

IPC Classes  ?

• A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes

Abstract

A system and method are provided for dynamically controlling operation of a mechanical ventilator for automatic targeting of a monitored parameter. A ventilator prescription includes an initial ventilator configuration, a prescribed target biometric value, comparator formulae for comparing a current condition value to the prescribed target biometric value, and modification formulae for generating modification parameters to modify the current configuration of the system. The ventilator system (10) operates according to the initial configuration, continuously monitors patient biometric sensors and system biomarker calculators (34), periodically determines a current condition value, and compares the current condition value to the target biometric value. If the current condition value does not meet the target biometric value, the system generates modification parameters to modify the current configuration of the system and automatically reconfigures the current configuration according to the modification parameters to meet the prescribed target value.

IPC Classes  ?

• G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
• A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes
• G06F 18/00 - Pattern recognition
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment

Abstract

A system is provided for dynamically controlling operation of a ventilator for automatic adjustment of one or more operational settings based on patient biometric data. A ventilator prescription includes initial operational settings, minimum and maximum operational boundaries for each operational setting, a health score formulae for determining a current health score based on patient biometrics, an interval for evaluating current operational settings, and a selected optimization protocol for systematically trialing one of the operational settings to optimize the current health score. The ventilator starts with the initial configuration, monitors patient biometrics, periodically determines a current health score, systematically trials new operational settings and for each trialed setting that improves the Health Score resets the current configuration to the trialed confirmation (hill climbing methodology).

IPC Classes  ?

• G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
• A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes
• G06F 18/00 - Pattern recognition
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
• G05B 13/00 - Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion

Abstract

A system and method are provided for dynamically controlling operation of a mechanical ventilator for automatic targeting of a monitored parameter. A ventilator prescription includes an initial ventilator configuration, a prescribed target biometric value, comparator formulae for comparing a current condition value to the prescribed target biometric value, and modification formulae for generating modification parameters to modify the current configuration of the system. The ventilator system operates according to the initial configuration, continuously monitors patient biometric sensors and system biomarker calculators, periodically determines a current condition value, and compares the current condition value to the target biometric value. If the current condition value does not meet the target biometric value, the system generates modification parameters to modify the current configuration of the system and automatically reconfigures the current configuration according to the modification parameters to meet the prescribed target value.

IPC Classes  ?

• A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes
• A61M 16/06 - Respiratory or anaesthetic masks
• A61M 16/08 - BellowsConnecting tubes
• G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation

Abstract

A system is provided for dynamically controlling operation of a ventilator for automatic adjustment of one or more operational settings based on patient biometric data. A ventilator prescription includes initial operational settings, minimum and maximum operational boundaries for each operational setting, a health score formulae for determining a current health score based on patient biometrics, an interval for evaluating current operational settings, and a selected optimization protocol for systematically trialing one of the operational settings to optimize the current health score. The ventilator starts with the initial configuration, monitors patient biometrics, periodically determines a current health score, systematically trials new operational settings and for each trialed setting that improves the Health Score resets the current configuration to the trialed confirmation (hill climbing methodology).

IPC Classes  ?

• A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes
• G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
• G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment

Abstract

A system (10) and method are provided for dynamically controlling the operation of a mechanical ventilator. A saved prescription includes a base or therapeutic ventilation configuration, intervention logic for identifying an intervention entrance condition, and an intervention configuration. The ventilator system initially operates in the base configuration, continuously monitors readings from patient biometric sensors (34), continuously determines, according to the intervention logic and the monitored readings, if an intervention entrance condition is present. If the entrance condition is present, the system dynamically reconfigures into the intervention configuration. Intervention exit conditions are also programmed wherein during operation in the intervention configuration, the method continuously monitors readings from the biometric sensors, determines, according to the intervention logic and the monitored readings, if an intervention exit condition is present, and if exit conditions are present, reconfigures the ventilator system into the base configuration.

IPC Classes  ?

• G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
• G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
• G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
• A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes

Goods & Services

Breathing apparatus for medical purposes; respiratory masks for medical purposes.

Goods & Services

Antiseptics; chemico-pharmaceutical preparations; anaesthetics; pharmaceutical preparations; vaccines; anti-inflammatory preparations; pharmaceuticals for the treatment of infectious diseases; pharmaceutical preparations to be inhaled for the prevention and treatment of respiratory diseases and disorders; pharmaceuticals for the treatment of cancer; balsamic preparations for medical purposes; drugs for medical purposes; biological preparations for medical purposes; medicines for human purposes; diagnostic reagents for medical purposes; pharmaceuticals for the treatment of viral diseases; diagnostic preparations for medical purposes. Testing apparatus for medical purposes; medical apparatus and instruments. Retail or wholesale services for medical supplies; retail or wholesale services for medicines; retail or wholesale services for pharmaceutical preparations; marketing; sales promotion for others. Drug development; pharmaceutical research; clinical trials.

Goods & Services

(1) Breathing apparatus for medical purposes; respiratory masks for medical purposes.

Goods & Services

Breathing apparatus for medical purposes; Respiratory masks for medical purposes

Abstract

The present application relates to a compound as represented by formula I, an isomer, an isotope marker or a pharmaceutically acceptable salt thereof, and the uses thereof as an ATR kinase inhibitor and for treating cancers, wherein each group is as defined herein.

IPC Classes  ?

• C07D 487/06 - Peri-condensed systems
• C07D 498/04 - Ortho-condensed systems
• C07D 471/16 - Peri-condensed systems
• A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention relates to a compound as represented by formula I, a pharmaceutically acceptable salt, an isomer, or an isotope marker thereof. The compound can be used as an LSD1 inhibitor, and can also be used for preventing or treating tumors such as hematological neoplasms and small cell lung cancer.

IPC Classes  ?

• C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 471/04 - Ortho-condensed systems
• C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
• C07D 487/04 - Ortho-condensed systems
• A61P 35/00 - Antineoplastic agents
• A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline

Goods & Services

Respiratory masks for medical purposes.

Goods & Services

breathing apparatus for medical purposes and medical apparatus for assisting breathing

Goods & Services

Respiratory masks for medical purposes

Goods & Services

breathing apparatus for medical purposes and medical apparatus for assisting breathing

Goods & Services

Retail or wholesale services for medical supplies; retail or wholesale services for medicines; retail or wholesale services for pharmaceutical preparations; marketing; sales promotion for others. Antiseptics; chemico-pharmaceutical preparations; anaesthetics; pharmaceutical preparations; vaccines; anti-inflammatory preparations; pharmaceuticals for the treatment of infectious diseases; pharmaceutical preparations to be inhaled for the prevention and treatment of respiratory diseases and disorders; pharmaceuticals for the treatment of cancer; balsamic preparations for medical purposes; drugs for medical purposes; biological preparations for medical purposes; medicines for human purposes; diagnostic reagents for medical purposes; pharmaceuticals for the treatment of viral diseases; diagnostic preparations for medical purposes. Testing apparatus for medical purposes; medical apparatus and instruments. Drug development; pharmaceutical research; clinical trials.

Goods & Services

Respiratory masks for medical purposes.

Goods & Services

Medical apparatus and instruments, namely, medical respiratory apparatus to enhance breathing; medical devices for treating sleep disorders, namely, sleep screening apparatus and accessories thereto.

Goods & Services

(1) Respiratory masks for medical purposes.

Goods & Services

Respiratory masks for medical purposes

Abstract

A mucus clearance system and method for automatically adjusting various parameters of a ventilator, including Fall Time, Rise Time, and Inspiratory Time, within a prescribed pressure, which are adjusted and based on sensor input data to achieve a targeted Flow Bias difference or ratio.

IPC Classes  ?

• A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes
• A61M 16/06 - Respiratory or anaesthetic masks

Abstract

A mucus clearing assistance system (100) comprises: - a ventilator system (10) configured to provide positive air pressure to a user; - one or more sensors (34) configured to detect flow rate associated with the ventilator; and - a controller configured to change one or more output parameters associated with the ventilator, wherein the controller has programmable logic or memory (32) and a processing unit (30) configured to perform the following steps: - - receive a target flow bias ratio input, - - receive from the one or more sensors, a measured flow rate, - - determine from the measured flow rate a flow bias ratio, - - compare the measured flow bias ratio to the target bias ratio, - - determine if the measured flow bias ratio needs to be increased or decreased, and - - modifying at least one of: a fall time parameter, a rise time parameter, and an inspiratory time parameter based on the determination to increase or decrease the measured flow bias ratio.

IPC Classes  ?

• A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes

Goods & Services

Medical apparatus and instruments, namely, medical respiratory apparatus to enhance breathing; and medical devices for treating sleep disorders, namely, sleep screening apparatus and accessories thereto.

Goods & Services

(1) Medical apparatus and instruments, namely, medical respiratory apparatus to enhance breathing; and medical devices for treating sleep disorders, namely, sleep screening apparatus and accessories thereto.

Abstract

Disclosed in the present invention is a crystalline form of fluvatinib or fluvatinib methanesulfonate, and a preparation method therefor. The crystalline form I of the fluvatinib has characteristic diffraction peaks as shown in FIG. 1. The crystalline form of the fluvatinib methanesulfonate may take multiple forms, including seven crystalline forms, forms I-VII, wherein crystalline form III has characteristic diffraction peaks as shown in FIG. 9. Said crystalline forms are suited to manufacturing processes for fluvatinib methanesulfonate formulations.

IPC Classes  ?

• C07D 215/22 - Oxygen atoms attached in position 2 or 4
• A61K 9/20 - Pills, lozenges or tablets

Goods & Services

Medical genetic characteristics test reagents; antiseptics; bath preparations for medical purposes; chemico-pharmaceutical preparations; anaesthetics; pharmaceutical preparations; vaccines; medicine cases, portable, filled; lotions for pharmaceutical purposes; liniments; nutritive substances for microorganisms; sedatives; styptic preparations; chemical preparations for pharmaceutical purposes; medicinal drinks; medicated soap; medicines in form of tablet form; medicinal oil solutions; prepared Chinese medicines; tonics [medicines]; immunostimulants; liquid medicines; adhesive patches for medical purposes; blood products; anti-inflammatory preparations; pharmaceuticals for the treatment of infectious diseases; pharmaceutical preparations to be inhaled for the prevention and treatment of respiratory diseases and disorders; slimming pills; injectable medicinal solutions; medicinal ointments; biochemical medicines; pharmaceuticals for the treatment of cancer; pharmaceutical preparations for the treatment of hypercholesteremia; nutraceutical preparations for therapeutic or medical purposes; tinctures for medical purposes; active pharmaceutical ingredient; bacteriological preparations for medical purposes; pharmaceutical preparations for the treatment of hyperlipidemia; oral care preparations, medicated; reagents for use in medical genetic testing; medicinal alcohol; balsamic preparations for medical purposes; capsules for medicines; vitamin preparations; disinfectants; drugs for medical purposes; medicinal tea; suppositories; biological preparations for medical purposes; medicines for human purposes; chemical reagents for medical or veterinary purposes; diagnostic reagents for medical purposes; pharmaceuticals for the treatment of viral diseases; medical immunoassay reagents; chemical preparations for the diagnosis of pregnancy; pharmaceutical preparations for skin care; diagnostic preparations for medical purposes; antibiotics; dietetic foods adapted for medical purposes; nutritional supplements; food for babies; dietetic beverages adapted for medical purposes; infant formula; depuratives; medicines for veterinary purposes; pesticides; biocides; bandages for dressings; babies' diapers; dressings, medical; wadding for medical purposes; pants, absorbent, for incontinence; medicinal health kit; eyepatches for medical purposes; adhesive tapes for medical purposes; tissues impregnated with pharmaceutical lotions; disinfectant wipes; surgical glues; dental abrasives; teeth filling material; dental mastics; alloys of precious metals for dental purposes; diapers for pets. Retail or wholesale services for medical supplies; retail or wholesale services for sanitary preparations; retail or wholesale services for medicines; retail or wholesale services for pharmaceutical preparations. Grinding; processing of medicinal materials; services of a dental technician; processing of chemical reagents. Drug development; pharmaceutical product evaluation; pharmaceutical research; conducting early evaluations in the field of new pharmaceuticals; scientific research and development; scientific investigations for medical purposes; technological research; pharmaceutical research; chemical research; cosmetic research; biochemical research and analysis; biological research; clinical trials; bacteriological research; biological cloning services; DNA screening for scientific research purposes; bacteriological research and analysis; material testing.

Goods & Services

Medical apparatus and instruments, namely, medical respiratory apparatus to enhance breathing; and medical devices for treating sleep disorders, namely, sleep screening apparatus and accessories thereto

Abstract

The present teachings relate to a device and a method for treating a subject, wherein an actuator is configured for external mechanical contact with the subject, wherein a control unit is configured to control the actuator to provide at least one burst of a primary vibration, and wherein the primary vibration has one or several frequencies, or a frequency varying, within an operative frequency range contained in a range from 5 Hz to 1000 Hz, in order for the device to generate a shear wave which propagates inside the body of the subject. In addition, the present teachings relate to use of a device of the present teachings to treat a breathing-related sleep disorder, including snoring, OSA, UARS, or OHS.

IPC Classes  ?

• A61H 23/02 - Percussion or vibration massage, e.g. using supersonic vibrationSuction-vibration massageMassage with moving diaphragms with electric or magnetic drive

Abstract

A crystalline form of fluvatinib or fluvatinib methanesulfonate, and a preparation method therefor. The crystalline form I of the fluvatinib has characteristic diffraction peaks as shown in FIG. 1. The crystalline form of the fluvatinib methanesulfonate may take multiple forms, including seven crystalline forms, forms I-VII, wherein crystalline form III has characteristic diffraction peaks as shown in FIG. 9. Said crystalline forms are suited to manufacturing processes for fluvatinib methanesulfonate formulations.

IPC Classes  ?

• C07D 215/48 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
• A61K 31/47 - QuinolinesIsoquinolines
• C07C 303/32 - Preparation of esters or amides of sulfuric acidsPreparation of sulfonic acids or of their esters, halides, anhydrides or amides of salts of sulfonic acids
• C07C 303/44 - SeparationPurification
• A61P 35/00 - Antineoplastic agents

Goods & Services

Software as a service (SAAS) services featuring software for use in monitoring, controlling, and transmitting data to and from medical respiratory devices.

Abstract

The present teachings relate to a device and a method for treating a subject, wherein an actuator is configured for external mechanical contact with the subject, wherein a control unit is configured to control the actuator to provide at least one burst of a primary vibration, and wherein the primary vibration has one or several frequencies, or a frequency varying, within an operative frequency range contained in a range from 5 Hz to 1000 Hz, in order for the device to generate a shear wave which propagates inside the body of the subject. In addition, the present teachings relate to use of a device of the present teachings to treat a breathing-related sleep disorder, including snoring, OSA, UARS, or OHS.

IPC Classes  ?

• A61H 23/02 - Percussion or vibration massage, e.g. using supersonic vibrationSuction-vibration massageMassage with moving diaphragms with electric or magnetic drive

Abstract

The present teachings relate to a device and a method for treating a subject, wherein an actuator is configured for external mechanical contact with the subject, wherein a control unit is configured to control the actuator to provide at least one burst of a primary vibration, and wherein the primary vibration has one or several frequencies, or a frequency varying, within an operative frequency range contained in a range from 5 Hz to 1000 Hz, in order for the device to generate a shear wave which propagates inside the body of the subject. In addition, the present teachings relate to use of a device of the present teachings to treat a breathing-related sleep disorder, including snoring, OSA, UARS, or OHS.

IPC Classes  ?

• A61H 23/02 - Percussion or vibration massage, e.g. using supersonic vibrationSuction-vibration massageMassage with moving diaphragms with electric or magnetic drive

Goods & Services

(1) Software as a service (SAAS) services featuring software for use in monitoring, controlling, and transmitting data to and from medical respiratory devices.

Goods & Services

Software as a service (SAAS) services featuring software for use in monitoring, controlling, and transmitting data to and from medical respiratory devices

Abstract

A medical ventilator system configured for use by an individual at home, the ventilator system including: an oxygen source; an air flow generator; an oxygen supply control valve; a patient supply tube; a pressure sensor; one or more flow sensors; a controller; wherein the airflow generator combines the amount of oxygen and the amount of ambient air to form breathing air, wherein the breathing air is supplied to the patient at a pressure above atmospheric pressure; and wherein the controller is operable to control a flow rate and pressure of the breathing air from the air flow generator and wherein the controller is operable to control an oxygen flow rate to the air flow generator from the oxygen source by selectively opening, closing, or throttling the oxygen control valve.

IPC Classes  ?

• A62B 7/00 - Respiratory apparatus
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

The present invention relates to the field of pharmaceutical chemistry, and particularly to a crystal form of Abiraterone propionate and a preparation method therefor. Characteristic diffraction peaks occur at positions, where the 2θ value is 5.7°, 11.9°, 12.4°, 14.9°, 15.8°, 16.7°, 18.5°, 19.1°, 21.7°, 22.4°, and 39.9°±0.2°, in an X-ray powder diffraction spectrum of the crystal form of Abiraterone propionate.

IPC Classes  ?

• C07J 43/00 - Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta[a]hydrophenanthrene skeleton

Abstract

Disclosed are a veliparib crystal form A and a preparation method thereof. 2θ values of an X-ray powder diffraction pattern of the veliparib crystal form A have characteristic diffraction peaks at 9.39 ± 0.2°, 13.38 ± 0.2°, 17.25 ± 0.2°, 17.70 ± 0.2°, 18.94 ± 0.2°, 21.79 ± 0.2°, 22.77 ± 0.2°, 24.65 ± 0.2°, 28.98 ± 0.2°, 31.60 ± 0.2°, and 36.61 ± 0.2°. The preparation method of the veliparib crystal form A is easy to perform, provides a high yield, high purity, and stability, and is suitable for manufacturing a preparation of the veliparib crystal form A.

IPC Classes  ?

• C07D 403/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond

Abstract

A turbulator adapted to be mounted to or inserted in an inlet portion of a flow meter for a ventilator is disclosed. The turbulator is adapted to create a turbulent gas flow in the inlet portion downstream of the turbulator upon passage of a gas flow therethrough. A flow meter for a ventilator is provided. The flow meter may comprise such turbulator. The turbulator may be arranged in the inlet portion of the flow meter. A membrane for a ventilator flow meter is provided, as well as a flow meter comprising the membrane. A flow meter comprising a turbulator and a membrane is disclosed.

IPC Classes  ?

• G01F 1/38 - Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by using mechanical effects by measuring pressure or differential pressure the pressure or differential pressure being created by the use of flow constriction the pressure or differential pressure being measured by means of a movable element, e.g. diaphragm, piston, Bourdon tube or flexible capsule
• G01F 1/36 - Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by using mechanical effects by measuring pressure or differential pressure the pressure or differential pressure being created by the use of flow constriction
• G01F 1/40 - Details of construction of the flow constriction devices
• G01F 1/44 - Venturi tubes
• G01F 15/00 - Details of, or accessories for, apparatus of groups insofar as such details or appliances are not adapted to particular types of such apparatus
• A61M 16/20 - Valves specially adapted to medical respiratory devices
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes
• A61M 16/10 - Preparation of respiratory gases or vapours
• A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition

Abstract

The present invention relates to the field of pharmaceutical chemistry, and particularly to a crystal form of Abiraterone propionate and a preparation method therefor. Characteristic diffraction peaks occur at positions, where the 2θ value is 5.7°, 11.9°, 12.4°, 14.9°, 15.8°, 16.7°, 18.5°, 19.1°, 21.7°, 22.4°, and 39.9°±0.2°, in an X-ray powder diffraction spectrum of the crystal form of Abiraterone propionate.

IPC Classes  ?

• C07J 43/00 - Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta[a]hydrophenanthrene skeleton
• A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
• A61P 35/00 - Antineoplastic agents
• A61P 13/08 - Drugs for disorders of the urinary system of the prostate

Abstract

A handheld device (100) for supplying at least inspiratory gas pressure to a patient (101), comprising a gas flow generator (110) adapted to generate a gas flow to the patient (101) via a patient gas outlet portion (120) of the handheld device (100) such that a predetermined inspiratory gas pressure at an end (121) of the patient gas outlet portion (120) is obtained. The handheld device enables a user to easily carry and use the handheld device to receive inspiratory gas in an easy manner.

IPC Classes  ?

• A61M 16/10 - Preparation of respiratory gases or vapours
• A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes
• A61M 16/20 - Valves specially adapted to medical respiratory devices
• A62B 25/00 - Devices for storing respiratory or breathing apparatus
• A62B 7/02 - Respiratory apparatus with compressed oxygen or air

Goods & Services

Sales promotion services for third parties; commercial administration of the licensing of the goods and services of others; presentation of goods on communication media, for retail purposes. Medicinal materials processing; processing of chemical reagents.

Abstract

Example embodiments presented herein are directed towards a system, and corresponding method, for providing ventilation synchronization between breathing gas supplied by a mechanical ventilator and the breathing needs of a patient. In providing the ventilation synchronization, a total amount of energy required during an inspiratory phase of breathing is calculated. Based on the calculated energy, a decay factor is determined. The decay factor is supplied to an inspiratory triggering system in order to provide the ventilation synchronization.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• A61B 5/0402 - Electrocardiography, i.e. ECG
• A61B 5/08 - Measuring devices for evaluating the respiratory organs
• A61B 5/087 - Measuring breath flow
• A61B 5/113 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb occurring during breathing
• A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
• A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes
• A61M 16/10 - Preparation of respiratory gases or vapours

Goods & Services

Sales promotion services for third parties; business assistance, advisory and consulting services in the field of commercial administration of the licensing of the goods and services of others; presentation of goods on all forms of media communications stations, systems, networks, and services for the purpose of promoting the goods and services of others Medicinal materials processing, comprising slicing, steaming and soaking of medicinal materials; processing of chemical reagents used for preparation, production and application guidance of polymerace chain reaction (PCR) agents for testing of samples such as serum, sputum and secretions as well as for preparation, production and application guidance of biochemical agents used in testing of samples such as blood and body fluids

Abstract

A turbulator adapted to be mounted to or inserted in an inlet portion of a flow meter for a ventilator is disclosed. The turbulator is adapted to create a turbulent gas flow in the inlet portion downstream of the turbulator upon passage of a gas flow therethrough. A flow meter for a ventilator is provided. The flow meter may comprise such turbulator. The turbulator may be arranged in the inlet portion of the flow meter. A membrane for a ventilator flow meter is provided, as well as a flow meter comprising the membrane. A flow meter comprising a turbulator and a membrane is disclosed.

IPC Classes  ?

• A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes
• G01F 1/44 - Venturi tubes
• G01F 15/00 - Details of, or accessories for, apparatus of groups insofar as such details or appliances are not adapted to particular types of such apparatus

Abstract

A turbulator adapted to be mounted to or inserted in an inlet portion of a flow meter for a ventilator is disclosed. The turbulator is adapted to create a turbulent gas flow in the inlet portion downstream of the turbulator upon passage of a gas flow therethrough. A flow meter for a ventilator is provided. The flow meter may comprise such turbulator. The turbulator may be arranged in the inlet portion of the flow meter. A membrane for a ventilator flow meter is provided, as well as a flow meter comprising the membrane. A flow meter comprising a turbulator and a membrane is disclosed.

IPC Classes  ?

• A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes
• G01F 1/44 - Venturi tubes
• G01F 15/00 - Details of, or accessories for, apparatus of groups insofar as such details or appliances are not adapted to particular types of such apparatus

Abstract

The present invention belongs to the technical field of pharmaceutical chemistry. Disclosed are quinoline derivates, preparation method therefor, and application thereof. Compounds provided by the present invention are the compounds represented by formula I or optical isomers, racemates, diastereoisomers, pharmaceutically acceptable salts or solvates thereof. The compounds have a significant killing effect on Mycobacterium tuberculosis, and can be used to prepare medicines for treating or preventing diseases or symptoms caused by the infection of Mycobacterium tuberculosis.

IPC Classes  ?

• C07D 401/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• A61K 31/4709 - Non-condensed quinolines containing further heterocyclic rings
• A61P 31/06 - Antibacterial agents for tuberculosis
• C07D 207/08 - Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
• C07D 213/50 - Ketonic radicals
• C07D 211/32 - Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms

Abstract

Example embodiments presented herein are directed towards a system, and corresponding method, for providing ventilation synchronization between breathing gas supplied by a mechanical ventilator and the breathing needs of a patient. In providing the ventilation synchronization, a total amount of energy required during an inspiratory phase of breathing is calculated. Based on the calculated energy, a decay factor is determined. The decay factor is supplied to an inspiratory triggering system in order to provide the ventilation synchronization.

IPC Classes  ?

• A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes

Goods & Services

Apparatus and instruments for conducting, switching, transforming, regulating or controlling electricity, excluding machines for the metallurgical industry and machines for the steel making industry

Goods & Services

Apparatus and instruments for conducting, switching, transforming, regulating or controlling electricity.

Abstract

A stable oral solid drug composition of abiraterone comprises abiraterone acetate and citrate which serves as a pharmaceutical adjuvant, wherein the weight ratio of citrate to abiraterone acetate is 1:100 to 1:5.

IPC Classes  ?

• A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
• A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention provides a stable composition of rasagiline comprising an effective dosage of rasagiline or its pharmaceutically acceptable salts and an antioxidant used as a stabilizer. The dosage forms of the composition are pharmaceutically common transdermal-drug delivery dosage form and mucoadhesive delivery dosage form, such as patch, gel, ointment, cream, cataplasm, film, spray and solution, etc. The composition can be used to prevent or treat mental disorders.

IPC Classes  ?

• A01N 33/02 - AminesQuaternary ammonium compounds
• A61K 31/135 - Amines, e.g. amantadine having aromatic rings, e.g. methadone
• A61F 13/00 - Bandages or dressingsAbsorbent pads
• A61K 9/70 - Web, sheet or filament bases
• A61K 31/355 - Tocopherols, e.g. vitamin E
• A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 47/10 - AlcoholsPhenolsSalts thereof, e.g. glycerolPolyethylene glycols [PEG]PoloxamersPEG/POE alkyl ethers
• A61K 9/06 - OintmentsBases therefor
• A61K 31/375 - Ascorbic acid, i.e. vitamin CSalts thereof

Abstract

A transdermal patch of Rasagiline comprises Rasagiline or pharmaceutically acceptable salts thereof, a base substance and an inert back layer. The oxygen transmissivity of the back layer is not more than 100 cm3 /m2 /24h，which can effectively reduce the volatilization of the Rasagiline from the back layer which results in decreased content, thus a long term sustained treatment effect is ensured.

IPC Classes  ?

• A61K 9/70 - Web, sheet or filament bases
• A61K 31/135 - Amines, e.g. amantadine having aromatic rings, e.g. methadone
• A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
• A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
• A61P 25/00 - Drugs for disorders of the nervous system

Abstract

Disclosed is a preparation method for a morphinan bromide quaternary ammonium salt as represented by Formula (I). The method comprises: transforming a compound as represented by Formula (II) in a compound as represented by Formula (I) by an ion-exchange using a brominated strongly basic anion-exchange resin. The definitions of A, R1, R1 and X- found in Formula (I) and Formula (II) are as presented in the description.

IPC Classes  ?

• C07D 489/08 - Oxygen atom

Abstract

Three new crystalline forms of pemetrexed diacid, preparation methods and uses thereof are disclosed. These preparation processes are simple and have better practicality.

IPC Classes  ?

• C07D 487/04 - Ortho-condensed systems

Abstract

A preparation method of ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl-5-thiazolecarboxylate as a key intermediate of febuxostat is provided. The preparation method comprises: using thioacetamide and p-cyanophenol as raw materials which are reacted in an acid aqueous solution to obtain 4-hydroxy thiobenzamide, and reacting 4-hydroxy thiobenzamide with ethyl 2- chloroacetoacetate to obtain ethyl 2-(4-hydroxyphenyl)-4-methyl-5-thiazolecarboxylate, and reacting the obtained compound with methenamine in the presence of polyphosphoric acid and methanesulfonic acid to obtain ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl-5-thiazolecarboxylate.

IPC Classes  ?

• C07C 237/48 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring being part of a condensed ring system of the same carbon skeleton
• C07D 277/56 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Abstract

The present invention provides a stable composition of rasagiline comprising an effective dosage of rasagiline or its pharmaceutically acceptable salts and an antioxidant used as a stabilizer. The dosage forms of the composition are pharmaceutically common transdermal-drug delivery dosage form and mucoadhesive delivery dosage form, such as patch, gel, ointment, cream, cataplasm, film, spray and solution, etc. The composition can be used to prevent or treat mental disorders.

IPC Classes  ?

• A61K 9/06 - OintmentsBases therefor
• A61K 9/107 - Emulsions
• A61K 9/70 - Web, sheet or filament bases
• A61K 31/135 - Amines, e.g. amantadine having aromatic rings, e.g. methadone
• A61P 25/00 - Drugs for disorders of the nervous system
• A61P 25/16 - Anti-Parkinson drugs
• A61P 25/24 - Antidepressants

Abstract

The present invention provides a stable composition of rasagiline comprising an effective dosage of rasagiline or its pharmaceutically acceptable salts and antioxidant used as stabilizer. The dosage forms of the composition are pharmaceutically common transdermal-drug delivery dosage form and mucoadhesive delivery dosage form, such as patch, gel, ointment, cream, cataplasm, film agent, spraying agent and solution etc. The composition can be used to prevent or treat mental disorders.

IPC Classes  ?

• A61K 31/135 - Amines, e.g. amantadine having aromatic rings, e.g. methadone
• A61K 9/70 - Web, sheet or filament bases
• A61K 9/107 - Emulsions
• A61K 9/06 - OintmentsBases therefor
• A61P 25/00 - Drugs for disorders of the nervous system
• A61P 25/16 - Anti-Parkinson drugs
• A61P 25/24 - Antidepressants

Abstract

Three new crystalline forms of Agomelatine, their preparation methods and the pharmaceutical compositions containing them and their preparation use of drug used for curing the diseases of central nervous system are provided. These three new crystalline forms of Agomelatine have the advantage of high stability and easy preparation and are suitable for the production of pharmaceutical preparation.

IPC Classes  ?

• C07C 233/18 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
• A61K 31/165 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
• A61P 5/00 - Drugs for disorders of the endocrine system
• A61P 25/00 - Drugs for disorders of the nervous system
• A61P 25/18 - Antipsychotics, i.e. neurolepticsDrugs for mania or schizophrenia
• A61P 25/20 - HypnoticsSedatives
• A61P 25/22 - Anxiolytics
• A61P 25/24 - Antidepressants
• A61P 9/00 - Drugs for disorders of the cardiovascular system
• A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system

Abstract

+.

IPC Classes  ?

• C07D 487/04 - Ortho-condensed systems

Abstract

High purified (2β,3α,5α,16β,17β) -2-(4-morpholinyl)-16-(1-pyrrolidinyl)-androstane-3,17-diol (formula III) or composition containing it and their use in preparing rocuronium bromide (formula I) are disclosed.

IPC Classes  ?

• C07J 43/00 - Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta[a]hydrophenanthrene skeleton
• A61P 21/02 - Muscle relaxants, e.g. for tetanus or cramps

Abstract

A febuxostat which purity is no less than 99.0％, method for preparation thereof, and pharmaceutical composition thereof. The said method for preparation includes recrystalling febuxostat in mixed solvent. The said pharmaceutical composition can be used in manufacture of medicaments for treating diseases associated with hyperuricemia.

IPC Classes  ?

• C07D 277/56 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
• A61K 31/426 - 1,3-Thiazoles
• A61P 19/06 - Antigout agents, e.g. antihyperuricemic or uricosuric agents

Abstract

Three new crystalline forms of pemetrexed diacid, preparation methods and uses thereof. These preparation processes are simple and have better practicality.

IPC Classes  ?

• C07D 487/04 - Ortho-condensed systems

Abstract

The invention discloses morphinan derivatives and their preparation method, especially discloses ketal hydroxyl protected compounds of morphinan derivatives and their preparation method, and the method for preparing corresponding alkylated morphinan derivatives using the said ketal hydroxyl protected compounds as intermediates, and more especially discloses ketal hydroxyl protected compound intermediates of methylnaltrexone for preparing methylnaltrexone and the method for preparing methylnaltrexone through said intermediates.

IPC Classes  ?

• C07D 489/08 - Oxygen atom
• C07D 489/09 - Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems

Abstract

A transdermal patch of rasagiline or pharmaceutically acceptable salts thereof for treating or preventing nervous system diseases. Particularly, a stable and release-controlled transdermal patch of rasagiline is provided, wherein the patch contains rasagiline or pharmaceutically acceptable salts thereof and at least one hydrophilic polymer matrix, moreover,  the pH value of the patch is less than 7.0. The patch has predominant stability and can well control the transdermal release characteristics of rasageline.

IPC Classes  ?

• A61K 31/135 - Amines, e.g. amantadine having aromatic rings, e.g. methadone
• A61K 9/70 - Web, sheet or filament bases
• A61P 25/16 - Anti-Parkinson drugs
• A61P 25/24 - Antidepressants
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Abstract

The present invention relates to a solution for controlling the pressure/flow of breathing gas to a mechanical ventilator (4) by using an energy of breathing analysis and further to provide a pressure relief during exhalation and a trigger determination when to start the pressure relief using energy content of breathing in analysis for determining a pressure curve form during at least a portion of the expiration phase.

IPC Classes  ?

• A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes
• A62B 7/00 - Respiratory apparatus
• F16K 31/02 - Operating meansReleasing devices electricOperating meansReleasing devices magnetic
• A61M 16/06 - Respiratory or anaesthetic masks

Abstract

A purification method of pemetrexed salts by means of salting-out. The pemetrexed salts are defined as formula (III) in which, (1) If M3+ is H+, then M1+ and M2+ are H+, Li+, Na+ or K+ independently. M1+ and M2+ are the same or not ,but they can not be H+ simultaneously; (2)If M3+ is Li+, Na+ or K+, then M1+ and M2+ are Li+, Na+ or K+ independently. M1+, M2+ and M3+ are the same or not.

IPC Classes  ?

• C07D 487/04 - Ortho-condensed systems
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61P 35/00 - Antineoplastic agents

Abstract

The medicine composition containing abafungin is provided in the present invention, and the said composition contains abafungin and other antibacterial agents. The use of the said medicine composition for treating fungus infections or fungus and bacteria mixed infections is also provided in the present invention.

IPC Classes  ?

• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/43 - Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula , e.g. penicillins, penems
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 31/545 - Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula , e.g. cephalosporins, cefaclor, cephalexine
• A61K 31/635 - Compounds containing para-N-benzene- sulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonohydrazide having a heterocyclic ring, e.g. sulfadiazine
• A61K 31/65 - Tetracyclines
• A61K 31/7034 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
• A61K 31/498 - Pyrazines or piperazines ortho- or peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
• A61K 31/7036 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
• A61K 31/7056 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
• A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
• A61K 31/04 - Nitro compounds
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/02 - SuppositoriesBougiesBases for suppositories or bougies
• A61K 9/06 - OintmentsBases therefor
• A61K 9/08 - Solutions
• A61K 9/107 - Emulsions
• A61K 9/20 - Pills, lozenges or tablets
• A61K 9/46 - Pills, lozenges or tablets effervescent
• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• A61P 31/04 - Antibacterial agents
• A61P 31/10 - Antimycotics

Abstract

A method and apparatus for facilitating breathing using a mechanical breathing gas ventilator is presented. The patient effort is deduced from a measured flow signal and analyzed with respect to the energy in the breathing system comprising the mechanical ventilator and the patient. When a predetermined energy threshold has been reached the ventilator responds to the breathing pattern change.

IPC Classes  ?

• A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes

Abstract

The invention provides preparation method of thioureas or salts thereof. In particular, the invention provides method of preparing thioureas by reacting cyanamides or salts thereof with thioamides in proper acidic medium. The product can be used to prepare 2-aminothiazoles, such as antimycotic abafungin.

IPC Classes  ?

• C07D 417/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 239/16 - Nitrogen atoms not forming part of a nitro radical acylated on said nitrogen atoms
• C07C 335/02 - Thiourea
• C01C 3/16 - CyanamideSalts thereof

Abstract

The present application belongs to pharmaceutical technology field. Three new crystal types of 2-(3-cyano-4-isobutyloxy) phenyl-4-methyl-5-thiazolecarboxylic acid (febuxostat) i.e. crystal types H, I and J and their preparation methods. Pharmaceutical compositions containing the new crystal types and the uses of crystal types as pharmaceutical medicaments for treatment diseases relating to excessive uric acid. Furthermore, the present application discloses X-ray diffraction characteristic absorption peak and IR absorption peak.

IPC Classes  ?

• C07D 277/56 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
• A61K 31/426 - 1,3-Thiazoles
• A61P 19/06 - Antigout agents, e.g. antihyperuricemic or uricosuric agents

Abstract

An antimycotic pharmaceutical composition comprising the 2-aminothiazoles of the general formula (I) and corticoid drugs and the use of which for the treatment or prevention skin infection caused by fungus, wherein the definition of substituent group of general formula (I) as described in the description. Particularly, the antimycotic pharmaceutical composition can be used to treat or prevent skin infection caused by fungus, superficial fungal diseases, itching, the mixed infection caused by fungus and bacterium or various dermatitis

IPC Classes  ?

• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/573 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
• A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
• A61K 31/57 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
• A61K 9/06 - OintmentsBases therefor
• A61K 9/08 - Solutions
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/7036 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
• A61K 31/7056 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
• A61K 31/5383 - 1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
• A61K 31/351 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
• A61K 31/155 - Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (HN=C(OH)NH2), isothiourea (HN=C(SH)—NH2)
• A61K 31/165 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
• A61K 31/345 - Nitrofurans
• A61P 15/02 - Drugs for genital or sexual disordersContraceptives for disorders of the vagina
• A61P 17/00 - Drugs for dermatological disorders
• A61P 31/10 - Antimycotics
• A61P 31/02 - Local antiseptics

Abstract

The present invention relates to a solution for controlling the pressure/flow of breathing gas to a mechanical ventilator (4) by using an energy of breathing analysis and further to provide a pressure relief during exhalation and a trigger determination when to start the pressure relief using energy content of breathing in analysis for determining a pressure curve form during at least a portion of the expiration phase.

IPC Classes  ?

• A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes

Abstract

A transdermal patch of rasagiline for treatment or prophylaxis of nervous system disease and its preparation process, comprises: a backing layer inert to the components of the matrix a matrix layer contg. rasagiline and its or its salt, and a removable protective layer, characterised in that the matrix is an adhesive system having distribured therein as polymer and organic or inorganic bulking agent and dermal penetration enhancer, the reservoir in the matrix layer contains rasagiline, said polymer is based on organic macromolecular material and useful as the active substance reservoir and adhesive.

IPC Classes  ?

• A61K 9/70 - Web, sheet or filament bases
• A61K 47/30 - Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
• A61K 31/135 - Amines, e.g. amantadine having aromatic rings, e.g. methadone
• A61P 25/00 - Drugs for disorders of the nervous system

Abstract

The present invention discloses a new pharmaceutical composition comprising, in well-distributed powder form : iron-saccharide complex and salt agent in a suitable amount or other excipient . It also discloses the process for preparation the composition , wherein the salt or other excipient is added before iron-saccharide complex is being dried . This improved process make API manufacturer prepare the hematinic powder which can be used just mixed with water , moreover , the powder is easy to reconstitute in water by the ordinary manufacturer .

IPC Classes  ?

• A61K 31/7012 - Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid
• A61K 31/555 - Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
• A61K 31/295 - Iron group metal compounds
• A61P 7/06 - Antianaemics

Abstract

A pharmaceutical composition for treating gout and its application in preparation of medicines for treating gout are provided. The said pharmaceutical composition comprises effective amount of febuxostat or its pharmaceutical salts or its solvates and a uric acid eliminant.

IPC Classes  ?

• A61K 31/425 - Thiazoles
• A61K 9/20 - Pills, lozenges or tablets
• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61K 9/08 - Solutions
• A61P 19/06 - Antigout agents, e.g. antihyperuricemic or uricosuric agents

Abstract

A ventilator apparatus, method, system, and computer program for determining leakage in a flow circuit providing pressurized gas to a patient having breathing disorder. The present invention determines the leakage by calculating a ratio between a measured flow of gas and a determined flow of gas related to a standard leakage. The determined standard leak flow may be calculated from a formula derived from Bernoulli's theorem. The invention may further be arranged to use a volume difference between inspiration and expiration phases in the compensation process.

IPC Classes  ?

• A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes
• A61B 5/087 - Measuring breath flow

Abstract

The invention discloses a process for preparing multinuclear ferric hydroxide-saccharidic complexes, comprising: titrating an aqueous solution of iron salt with an aqueous solution of alkali to a final pH of 68 under 520 , collecting the multinuclear ferric hydroxide from the reaction product by conventional method; maintaining a reaction mixture of multinuclear ferric hydroxide, saccharides and solution of alkali for 1040 hours under a temperature of 106125 and pH being 1012, and obtaining the crude product having an isoelectric point of 4.45.3 and a weight average molecular weight of 20000100000 Daltons, and then collecting the multinuclear ferric hydroxide-saccharidic complexes from the crude product. The process can control the molecular weight of the multinuclear ferric hydroxide-saccharidic complexes exactly while not influencing other characteristics of the product such as content of saccharides or isoelectric point etc, and which is simple and readily applicable in industry.

IPC Classes  ?

• C08B 37/02 - DextranDerivatives thereof
• A61K 31/715 - Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkagesDerivatives thereof, e.g. ethers, esters
• C07F 15/02 - Iron compounds

Goods & Services

Apparatus to enhance breathing (medical).

Goods & Services

Medical paste; chemico-pharmaceutical preparations; medicines for human purposes; dressings (medical); tissue paper impregnated with disinfectants; teeth filling material; medicinal drinks; adhesive tapes for medical purposes; dietetic food preparations adapted for medical purposes; solutions for contact lenses. Dental apparatus; hearing aids for the deaf; contraceptives, non-chemical; surgical implants; orthopedic articles; suture materials; furniture especially made for medical purposes; medical apparatus and instruments. Processing of medicinal materials; processing and handling of chemical reagents.

Goods & Services

Apparatus to enhance breathing (medical).

Goods & Services

(1) Surgical and topical anaesthetics; analgesics; antipyretics; non-steroidal anti-inflammatory medicines; medicines used to treat gout; medicines used to treat disease modifying agents in rheumatoid disorders;antiallergics; medicine used in anaphylaxis; antidotes to counteract poisons; anticonvulsants; anti-epileptics; anti-infectives; anti-migraine medicine; anti-neoplastic; immunosuppressives used in palliative care; pharmaceutical preparations for the treatment of the central nervous system, namely, encephalitis, epilepsy, Alzheimer's, cerebral palsy, Parkinson's disease; herbal supplements and pharmaceutical preparations for the treatment of cardiovascular diseases; pharmaceutical preparations for use in dermatology, namely, dermatitis, skin pigmentation diseases, sexually transmitted diseases; pharmaceutical preparations for the treatment of genitourinary diseases, namely, urological diseases, infertility, sexually transmitted diseases, inflammatory pelvic diseases; pharmaceutical preparations for the treatment of gastrointestinal diseases; hormones for humans, namely, human growth hormones, hormone replacement therapy preparations; contraceptives, namely, condoms, diaphragms, foams, oral, sponges, spermicides; opthalmological preparations; medicine acting on the respiratory tract; vitamins; minerals; PCR reagent used to test sputum; PCR reagent used in the hepatis; PCR reagent used in respiratory disease; PCR reagent used in venereal disease; PCR reagent used in bacterial disease; chemical preparations used to test blood; chemical preparations used to test sputum; pharmaceutical preparations for the treatment of blood disorders, the treatment of cancer, headaches, headaches, immunologic diseases, namely, autoimmune diseases, immunologic deficiency syndromes, infectious diseases, namely, respiratory infections, eye infections, inflammatory diseases, namely, inflammatory bowel diseases, inflammatory connective tissue diseases, psychiatric diseases, namely, mood disorders, anxiety disorders, cognitive disorders, the musculoskeletal system, namely, connective tissue disorders, bone diseases, spinal diseases, back pain, fractures, sprains, cartilage injuries, the respiratory system; pharmaceutical preparations for use in gastroenterology.

Goods & Services

Medical apparatus to enhance breathing, namely, medical ventilators

Goods & Services

medical apparatus to enhance breathing, namely, medical ventilators

Goods & Services

Medical apparatus and instruments.

Goods & Services

medical apparatus and instruments, namely, medical respiratory apparatus to enhance breathing; and sleep screening apparatus and accessories thereto for use with medical respiratory apparatus and with sleep screening apparatus, namely remote controls, remote alarms and nasal masks

Goods & Services

(1) Medical apparatus and instruments, namely apparatus to enhance breathing, sleep screening apparatus, accessories thereto, namely remote controls, remote alarms, nasal masks.