A system and method are provided for identifying breath variability events from patient respiratory data obtained during the operation of a mechanical ventilator. The ventilator monitors and saves patient respiratory data during operation. The method includes extracting treatment parameters from a ventilation prescription, and using the treatment parameters to determine an Epoch size and a frequency band for analysis. An input signal (flow or pressure) is extracted from the patient data and from the input signal at least one parameter is extracted and analyzed. A Spectral Energy (Es) of the input signal is determined based on the signal parameter, an Epoch size and a frequency band and a Spectral Entropy (SE) is determined based on the Spectral Energy (Es). The Spectral Entropy may then be displayed in graphical form to identify breath variability events over the Epoch size. The method may further classify the type and degree of the events.
A system and method are provided for identifying breath variability events from patient respiratory data obtained during the operation of a mechanical ventilator (10). The ventilator monitors and saves patient respiratory data during operation. The method includes extracting treatment parameters from a ventilation prescription, and using the treatment parameters to determine an Epoch size and a frequency band for analysis. An input signal (flow or pressure) is extracted from the patient data and from the input signal at least one parameter is extracted and analyzed. A Spectral Energy (Es) of the input signal is determined based on the signal parameter, an Epoch size and a frequency band and a Spectral Entropy (SE) is determined based on the Spectral Energy (Es). The Spectral Entropy may then be displayed in graphical form to identify breath variability events over the Epoch size. The method may further classify the type and degree of the events.
A system and method are provided for dynamically controlling the operation of a mechanical ventilator. A saved prescription includes a base or therapeutic ventilation configuration, intervention logic for identifying an intervention entrance condition, and an intervention configuration. The ventilator system initially operates in the base configuration, continuously monitors readings from patient biometric sensors, continuously determines, according to the intervention logic and the monitored readings, if an intervention entrance condition is present. If the entrance condition is present, the system dynamically reconfigures into the intervention configuration. Intervention exit conditions are also programmed wherein during operation in the intervention configuration, the method continuously monitors readings from the biometric sensors, determines, according to the intervention logic and the monitored readings, if an intervention exit condition is present, and if exit conditions are present, reconfigures the ventilator system into the base configuration.
A system and method are provided for dynamically controlling operation of a mechanical ventilator for automatic targeting of a monitored parameter. A ventilator prescription includes an initial ventilator configuration, a prescribed target biometric value, comparator formulae for comparing a current condition value to the prescribed target biometric value, and modification formulae for generating modification parameters to modify the current configuration of the system. The ventilator system (10) operates according to the initial configuration, continuously monitors patient biometric sensors and system biomarker calculators (34), periodically determines a current condition value, and compares the current condition value to the target biometric value. If the current condition value does not meet the target biometric value, the system generates modification parameters to modify the current configuration of the system and automatically reconfigures the current configuration according to the modification parameters to meet the prescribed target value.
G16H 20/40 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies mécaniques, la radiothérapie ou des thérapies invasives, p. ex. la chirurgie, la thérapie laser, la dialyse ou l’acuponcture
A61M 16/00 - Dispositifs pour agir sur le système respiratoire des patients par un traitement au gaz, p. ex. ventilateursTubes trachéaux
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
5.
SYSTEM AND METHODS FOR DYNAMICALLY CONTROLLING OPERATION OF A MECHANICAL VENTILATOR FOR AUTOMATIC ADJUSTMENT OF ONE OR MORE SETTINGS BASED ON PATIENT BIOMETRIC DATA
A system is provided for dynamically controlling operation of a ventilator for automatic adjustment of one or more operational settings based on patient biometric data. A ventilator prescription includes initial operational settings, minimum and maximum operational boundaries for each operational setting, a health score formulae for determining a current health score based on patient biometrics, an interval for evaluating current operational settings, and a selected optimization protocol for systematically trialing one of the operational settings to optimize the current health score. The ventilator starts with the initial configuration, monitors patient biometrics, periodically determines a current health score, systematically trials new operational settings and for each trialed setting that improves the Health Score resets the current configuration to the trialed confirmation (hill climbing methodology).
G16H 20/40 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies mécaniques, la radiothérapie ou des thérapies invasives, p. ex. la chirurgie, la thérapie laser, la dialyse ou l’acuponcture
A61M 16/00 - Dispositifs pour agir sur le système respiratoire des patients par un traitement au gaz, p. ex. ventilateursTubes trachéaux
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
G05B 13/00 - Systèmes de commande adaptatifs, c.-à-d. systèmes se réglant eux-mêmes automatiquement pour obtenir un rendement optimal suivant un critère prédéterminé
6.
SYSTEM AND METHODS FOR DYNAMICALLY CONTROLLING OPERATION OF A MECHANICAL VENTILATOR FOR AUTOMATIC TARGETING OF A MONITORED PARAMETER
A system and method are provided for dynamically controlling operation of a mechanical ventilator for automatic targeting of a monitored parameter. A ventilator prescription includes an initial ventilator configuration, a prescribed target biometric value, comparator formulae for comparing a current condition value to the prescribed target biometric value, and modification formulae for generating modification parameters to modify the current configuration of the system. The ventilator system operates according to the initial configuration, continuously monitors patient biometric sensors and system biomarker calculators, periodically determines a current condition value, and compares the current condition value to the target biometric value. If the current condition value does not meet the target biometric value, the system generates modification parameters to modify the current configuration of the system and automatically reconfigures the current configuration according to the modification parameters to meet the prescribed target value.
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
7.
SYSTEM AND METHODS FOR DYNAMICALLY CONTROLLING OPERATION OF A MECHANICAL VENTILATOR FOR AUTOMATIC ADJUSTMENT OF ONE OR MORE SETTINGS BASED ON PATIENT BIOMETRIC DATA
A system is provided for dynamically controlling operation of a ventilator for automatic adjustment of one or more operational settings based on patient biometric data. A ventilator prescription includes initial operational settings, minimum and maximum operational boundaries for each operational setting, a health score formulae for determining a current health score based on patient biometrics, an interval for evaluating current operational settings, and a selected optimization protocol for systematically trialing one of the operational settings to optimize the current health score. The ventilator starts with the initial configuration, monitors patient biometrics, periodically determines a current health score, systematically trials new operational settings and for each trialed setting that improves the Health Score resets the current configuration to the trialed confirmation (hill climbing methodology).
A61M 16/00 - Dispositifs pour agir sur le système respiratoire des patients par un traitement au gaz, p. ex. ventilateursTubes trachéaux
G16H 20/40 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies mécaniques, la radiothérapie ou des thérapies invasives, p. ex. la chirurgie, la thérapie laser, la dialyse ou l’acuponcture
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
8.
SYSTEM AND METHODS FOR DYNAMICALLY CONTROLLING OPERATION OF A MECHANICAL VENTILATOR FOR AUTOMATIC INTERVENTION DURING A DETECTED RESPIRATORY EPISODE
A system (10) and method are provided for dynamically controlling the operation of a mechanical ventilator. A saved prescription includes a base or therapeutic ventilation configuration, intervention logic for identifying an intervention entrance condition, and an intervention configuration. The ventilator system initially operates in the base configuration, continuously monitors readings from patient biometric sensors (34), continuously determines, according to the intervention logic and the monitored readings, if an intervention entrance condition is present. If the entrance condition is present, the system dynamically reconfigures into the intervention configuration. Intervention exit conditions are also programmed wherein during operation in the intervention configuration, the method continuously monitors readings from the biometric sensors, determines, according to the intervention logic and the monitored readings, if an intervention exit condition is present, and if exit conditions are present, reconfigures the ventilator system into the base configuration.
G16H 20/40 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies mécaniques, la radiothérapie ou des thérapies invasives, p. ex. la chirurgie, la thérapie laser, la dialyse ou l’acuponcture
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
A61M 16/00 - Dispositifs pour agir sur le système respiratoire des patients par un traitement au gaz, p. ex. ventilateursTubes trachéaux
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
35 - Publicité; Affaires commerciales
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Antiseptics; chemico-pharmaceutical preparations;
anaesthetics; pharmaceutical preparations; vaccines;
anti-inflammatory preparations; pharmaceuticals for the
treatment of infectious diseases; pharmaceutical
preparations to be inhaled for the prevention and treatment
of respiratory diseases and disorders; pharmaceuticals for
the treatment of cancer; balsamic preparations for medical
purposes; drugs for medical purposes; biological
preparations for medical purposes; medicines for human
purposes; diagnostic reagents for medical purposes;
pharmaceuticals for the treatment of viral diseases;
diagnostic preparations for medical purposes. Testing apparatus for medical purposes; medical apparatus
and instruments. Retail or wholesale services for medical supplies; retail or
wholesale services for medicines; retail or wholesale
services for pharmaceutical preparations; marketing; sales
promotion for others. Drug development; pharmaceutical research; clinical trials.
The present application relates to a compound as represented by formula I, an isomer, an isotope marker or a pharmaceutically acceptable salt thereof, and the uses thereof as an ATR kinase inhibitor and for treating cancers, wherein each group is as defined herein.
A61K 31/55 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole
The present invention relates to a compound as represented by formula I, a pharmaceutically acceptable salt, an isomer, or an isotope marker thereof. The compound can be used as an LSD1 inhibitor, and can also be used for preventing or treating tumors such as hematological neoplasms and small cell lung cancer.
C07D 401/04 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
C07D 519/00 - Composés hétérocycliques contenant plusieurs systèmes de plusieurs hétérocycles déterminants condensés entre eux ou condensés avec un système carbocyclique commun non prévus dans les groupes ou
A61K 31/437 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à cinq chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. indolizine, bêta-carboline
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Retail or wholesale services for medical supplies; retail or wholesale services for medicines; retail or wholesale services for pharmaceutical preparations; marketing; sales promotion for others. Antiseptics; chemico-pharmaceutical preparations; anaesthetics; pharmaceutical preparations; vaccines; anti-inflammatory preparations; pharmaceuticals for the treatment of infectious diseases; pharmaceutical preparations to be inhaled for the prevention and treatment of respiratory diseases and disorders; pharmaceuticals for the treatment of cancer; balsamic preparations for medical purposes; drugs for medical purposes; biological preparations for medical purposes; medicines for human purposes; diagnostic reagents for medical purposes; pharmaceuticals for the treatment of viral diseases; diagnostic preparations for medical purposes. Testing apparatus for medical purposes; medical apparatus and instruments. Drug development; pharmaceutical research; clinical trials.
Medical apparatus and instruments, namely, medical
respiratory apparatus to enhance breathing; medical devices
for treating sleep disorders, namely, sleep screening
apparatus and accessories thereto.
A mucus clearance system and method for automatically adjusting various parameters of a ventilator, including Fall Time, Rise Time, and Inspiratory Time, within a prescribed pressure, which are adjusted and based on sensor input data to achieve a targeted Flow Bias difference or ratio.
A mucus clearing assistance system (100) comprises: - a ventilator system (10) configured to provide positive air pressure to a user; - one or more sensors (34) configured to detect flow rate associated with the ventilator; and - a controller configured to change one or more output parameters associated with the ventilator, wherein the controller has programmable logic or memory (32) and a processing unit (30) configured to perform the following steps: - - receive a target flow bias ratio input, - - receive from the one or more sensors, a measured flow rate, - - determine from the measured flow rate a flow bias ratio, - - compare the measured flow bias ratio to the target bias ratio, - - determine if the measured flow bias ratio needs to be increased or decreased, and - - modifying at least one of: a fall time parameter, a rise time parameter, and an inspiratory time parameter based on the determination to increase or decrease the measured flow bias ratio.
Medical apparatus and instruments, namely, medical
respiratory apparatus to enhance breathing; and medical
devices for treating sleep disorders, namely, sleep
screening apparatus and accessories thereto.
(1) Medical apparatus and instruments, namely, medical respiratory apparatus to enhance breathing; and medical devices for treating sleep disorders, namely, sleep screening apparatus and accessories thereto.
29.
CRYSTALLINE FORM OF FLUVATINIB OR FLUVATINIB METHANESULFONATE AND PREPARATION METHOD THEREFOR
CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD (Chine)
YAOPHARMA CO., LTD. (Chine)
Inventeur(s)
He, Shuai
Zhang, Yang
Liu, Qiang
Chen, Zhengxia
Dai, Meibi
Fan, Bin
Xie, Peiyu
Abrégé
Disclosed in the present invention is a crystalline form of fluvatinib or fluvatinib methanesulfonate, and a preparation method therefor. The crystalline form I of the fluvatinib has characteristic diffraction peaks as shown in FIG. 1. The crystalline form of the fluvatinib methanesulfonate may take multiple forms, including seven crystalline forms, forms I-VII, wherein crystalline form III has characteristic diffraction peaks as shown in FIG. 9. Said crystalline forms are suited to manufacturing processes for fluvatinib methanesulfonate formulations.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
35 - Publicité; Affaires commerciales
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Medical genetic characteristics test reagents; antiseptics;
bath preparations for medical purposes;
chemico-pharmaceutical preparations; anaesthetics;
pharmaceutical preparations; vaccines; medicine cases,
portable, filled; lotions for pharmaceutical purposes;
liniments; nutritive substances for microorganisms;
sedatives; styptic preparations; chemical preparations for
pharmaceutical purposes; medicinal drinks; medicated soap;
medicines in form of tablet form; medicinal oil solutions;
prepared Chinese medicines; tonics [medicines];
immunostimulants; liquid medicines; adhesive patches for
medical purposes; blood products; anti-inflammatory
preparations; pharmaceuticals for the treatment of
infectious diseases; pharmaceutical preparations to be
inhaled for the prevention and treatment of respiratory
diseases and disorders; slimming pills; injectable medicinal
solutions; medicinal ointments; biochemical medicines;
pharmaceuticals for the treatment of cancer; pharmaceutical
preparations for the treatment of hypercholesteremia;
nutraceutical preparations for therapeutic or medical
purposes; tinctures for medical purposes; active
pharmaceutical ingredient; bacteriological preparations for
medical purposes; pharmaceutical preparations for the
treatment of hyperlipidemia; oral care preparations,
medicated; reagents for use in medical genetic testing;
medicinal alcohol; balsamic preparations for medical
purposes; capsules for medicines; vitamin preparations;
disinfectants; drugs for medical purposes; medicinal tea;
suppositories; biological preparations for medical purposes;
medicines for human purposes; chemical reagents for medical
or veterinary purposes; diagnostic reagents for medical
purposes; pharmaceuticals for the treatment of viral
diseases; medical immunoassay reagents; chemical
preparations for the diagnosis of pregnancy; pharmaceutical
preparations for skin care; diagnostic preparations for
medical purposes; antibiotics; dietetic foods adapted for
medical purposes; nutritional supplements; food for babies;
dietetic beverages adapted for medical purposes; infant
formula; depuratives; medicines for veterinary purposes;
pesticides; biocides; bandages for dressings; babies'
diapers; dressings, medical; wadding for medical purposes;
pants, absorbent, for incontinence; medicinal health kit;
eyepatches for medical purposes; adhesive tapes for medical
purposes; tissues impregnated with pharmaceutical lotions;
disinfectant wipes; surgical glues; dental abrasives; teeth
filling material; dental mastics; alloys of precious metals
for dental purposes; diapers for pets. Retail or wholesale services for medical supplies; retail or
wholesale services for sanitary preparations; retail or
wholesale services for medicines; retail or wholesale
services for pharmaceutical preparations. Grinding; processing of medicinal materials; services of a
dental technician; processing of chemical reagents. Drug development; pharmaceutical product evaluation;
pharmaceutical research; conducting early evaluations in the
field of new pharmaceuticals; scientific research and
development; scientific investigations for medical purposes;
technological research; pharmaceutical research; chemical
research; cosmetic research; biochemical research and
analysis; biological research; clinical trials;
bacteriological research; biological cloning services; DNA
screening for scientific research purposes; bacteriological
research and analysis; material testing.
Medical apparatus and instruments, namely, medical respiratory apparatus to enhance breathing; and medical devices for treating sleep disorders, namely, sleep screening apparatus and accessories thereto
32.
DEVICES AND METHODS FOR TREATING A BREATHING-RELATED SLEEP DISORDER, METHODS OF USE AND CONTROL PROCESSES FOR SUCH A DEVICE
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (France)
Inventeur(s)
Menguy, Didier
Chapelon, Jean-Yves
Catheline, Stefan
Zorgani, Ali
Abrégé
The present teachings relate to a device and a method for treating a subject, wherein an actuator is configured for external mechanical contact with the subject, wherein a control unit is configured to control the actuator to provide at least one burst of a primary vibration, and wherein the primary vibration has one or several frequencies, or a frequency varying, within an operative frequency range contained in a range from 5 Hz to 1000 Hz, in order for the device to generate a shear wave which propagates inside the body of the subject. In addition, the present teachings relate to use of a device of the present teachings to treat a breathing-related sleep disorder, including snoring, OSA, UARS, or OHS.
A61H 23/02 - Massage par percussion ou vibration, p. ex. en utilisant une vibration ultrasoniqueMassage par succion-vibrationMassage avec des membranes mobiles à entraînement électrique ou magnétique
33.
CRYSTALLINE FORM OF FLUVATINIB OR FLUVATINIB METHANESULFONATE AND PREPARATION METHOD THEREFOR
CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD (Chine)
YAOPHARMA CO., LTD. (Chine)
Inventeur(s)
He, Shuai
Zhang, Yang
Liu, Qiang
Chen, Zhengxia
Dai, Meibi
Fan, Bin
Xie, Peiyu
Abrégé
A crystalline form of fluvatinib or fluvatinib methanesulfonate, and a preparation method therefor. The crystalline form I of the fluvatinib has characteristic diffraction peaks as shown in FIG. 1. The crystalline form of the fluvatinib methanesulfonate may take multiple forms, including seven crystalline forms, forms I-VII, wherein crystalline form III has characteristic diffraction peaks as shown in FIG. 9. Said crystalline forms are suited to manufacturing processes for fluvatinib methanesulfonate formulations.
C07C 303/32 - Préparation d'esters ou d'amides d'acides sulfuriquesPréparation d'acides sulfoniques ou de leurs esters, halogénures, anhydrides ou amides de sels d'acides sulfoniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Software as a service (SAAS) services featuring software for
use in monitoring, controlling, and transmitting data to and
from medical respiratory devices.
35.
DEVICES AND METHODS FOR TREATING A BREATHING-RELATED SLEEP DISORDER, METHODS OF USE AND CONTROL PROCESSES FOR SUCH A DEVICE
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (France)
Inventeur(s)
Menguy, Didier
Chapelon, Jean-Yves
Catheline, Stefan
Zorgani, Ali
Abrégé
The present teachings relate to a device and a method for treating a subject, wherein an actuator is configured for external mechanical contact with the subject, wherein a control unit is configured to control the actuator to provide at least one burst of a primary vibration, and wherein the primary vibration has one or several frequencies, or a frequency varying, within an operative frequency range contained in a range from 5 Hz to 1000 Hz, in order for the device to generate a shear wave which propagates inside the body of the subject. In addition, the present teachings relate to use of a device of the present teachings to treat a breathing-related sleep disorder, including snoring, OSA, UARS, or OHS.
A61H 23/02 - Massage par percussion ou vibration, p. ex. en utilisant une vibration ultrasoniqueMassage par succion-vibrationMassage avec des membranes mobiles à entraînement électrique ou magnétique
36.
DEVICES AND METHODS FOR TREATING A BREATHING-RELATED SLEEP DISORDER, METHODS OF USE AND CONTROL PROCESSES FOR SUCH A DEVICE
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (France)
UNIVERSITE CLAUDE BERNARD LYON 1 (France)
CENTRE LEON-BERARD (France)
Inventeur(s)
Menguy, Didier
Chapelon, Jean-Yves
Catheline, Stefan
Zorgani, Ali
Abrégé
The present teachings relate to a device and a method for treating a subject, wherein an actuator is configured for external mechanical contact with the subject, wherein a control unit is configured to control the actuator to provide at least one burst of a primary vibration, and wherein the primary vibration has one or several frequencies, or a frequency varying, within an operative frequency range contained in a range from 5 Hz to 1000 Hz, in order for the device to generate a shear wave which propagates inside the body of the subject. In addition, the present teachings relate to use of a device of the present teachings to treat a breathing-related sleep disorder, including snoring, OSA, UARS, or OHS.
A61H 23/02 - Massage par percussion ou vibration, p. ex. en utilisant une vibration ultrasoniqueMassage par succion-vibrationMassage avec des membranes mobiles à entraînement électrique ou magnétique
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
(1) Software as a service (SAAS) services featuring software for use in monitoring, controlling, and transmitting data to and from medical respiratory devices.
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Software as a service (SAAS) services featuring software for use in monitoring, controlling, and transmitting data to and from medical respiratory devices
39.
SYSTEMS AND METHODS FOR AUTOMATICALLY ADJUSTING A FIO2 SUPPLY GENERATED FROM A VENTILATOR SYSTEM
A medical ventilator system configured for use by an individual at home, the ventilator system including: an oxygen source; an air flow generator; an oxygen supply control valve; a patient supply tube; a pressure sensor; one or more flow sensors; a controller; wherein the airflow generator combines the amount of oxygen and the amount of ambient air to form breathing air, wherein the breathing air is supplied to the patient at a pressure above atmospheric pressure; and wherein the controller is operable to control a flow rate and pressure of the breathing air from the air flow generator and wherein the controller is operable to control an oxygen flow rate to the air flow generator from the oxygen source by selectively opening, closing, or throttling the oxygen control valve.
CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD (Chine)
Inventeur(s)
Xing, Naiguo
Shangguan, Yan
Zheng, Deping
Chen, Fanglu
Abrégé
The present invention relates to the field of pharmaceutical chemistry, and particularly to a crystal form of Abiraterone propionate and a preparation method therefor. Characteristic diffraction peaks occur at positions, where the 2θ value is 5.7°, 11.9°, 12.4°, 14.9°, 15.8°, 16.7°, 18.5°, 19.1°, 21.7°, 22.4°, and 39.9°±0.2°, in an X-ray powder diffraction spectrum of the crystal form of Abiraterone propionate.
C07J 43/00 - Stéroïdes normaux ayant un hétérocycle contenant de l'azote non condensé ou condensé en spiro avec le squelette du cyclopenta[a]hydrophénanthrène
41.
VELIPARIB CRYSTAL FORM A AND PREPARATION METHOD THEREOF
CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD. (Chine)
Inventeur(s)
Peng, Jun
Zhu, Zhiping
Yuan, Xing
Xia, Rong
Zheng, Deping
Abrégé
Disclosed are a veliparib crystal form A and a preparation method thereof. 2θ values of an X-ray powder diffraction pattern of the veliparib crystal form A have characteristic diffraction peaks at 9.39 ± 0.2°, 13.38 ± 0.2°, 17.25 ± 0.2°, 17.70 ± 0.2°, 18.94 ± 0.2°, 21.79 ± 0.2°, 22.77 ± 0.2°, 24.65 ± 0.2°, 28.98 ± 0.2°, 31.60 ± 0.2°, and 36.61 ± 0.2°. The preparation method of the veliparib crystal form A is easy to perform, provides a high yield, high purity, and stability, and is suitable for manufacturing a preparation of the veliparib crystal form A.
C07D 403/04 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
A turbulator adapted to be mounted to or inserted in an inlet portion of a flow meter for a ventilator is disclosed. The turbulator is adapted to create a turbulent gas flow in the inlet portion downstream of the turbulator upon passage of a gas flow therethrough. A flow meter for a ventilator is provided. The flow meter may comprise such turbulator. The turbulator may be arranged in the inlet portion of the flow meter. A membrane for a ventilator flow meter is provided, as well as a flow meter comprising the membrane. A flow meter comprising a turbulator and a membrane is disclosed.
G01F 1/38 - Mesure du débit volumétrique ou du débit massique d'un fluide ou d'un matériau solide fluent, dans laquelle le fluide passe à travers un compteur par un écoulement continu en utilisant des effets mécaniques en mesurant la pression ou la différence de pression la pression ou la différence de pression étant produite par une contraction de la veine fluide la pression ou la différence de pression étant mesurée au moyen d'un élément mobile, p. ex. une membrane, un piston, un tube de Bourdon ou une capsule déformable
G01F 1/36 - Mesure du débit volumétrique ou du débit massique d'un fluide ou d'un matériau solide fluent, dans laquelle le fluide passe à travers un compteur par un écoulement continu en utilisant des effets mécaniques en mesurant la pression ou la différence de pression la pression ou la différence de pression étant produite par une contraction de la veine fluide
G01F 1/40 - Détails de structure des dispositifs de contraction de la veine fluide
G01F 15/00 - Détails des appareils des groupes ou accessoires pour ces derniers, dans la mesure où de tels accessoires ou détails ne sont pas adaptés à ces types particuliers d'appareils, p. ex. pour l'indication à distance
A61M 16/20 - Valves spécialement adaptées aux dispositifs respiratoires médicaux
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61M 16/00 - Dispositifs pour agir sur le système respiratoire des patients par un traitement au gaz, p. ex. ventilateursTubes trachéaux
A61M 16/10 - Préparation de gaz ou vapeurs à respirer
A61B 5/0205 - Évaluation simultanée de l'état cardio-vasculaire et de l'état d'autres parties du corps, p. ex. de l'état cardiaque et respiratoire
43.
CRYSTAL FORM OF ABIRATERONE PROPIONATE AND PREPARATION METHOD THEREFOR 104710499A
CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD (Chine)
Inventeur(s)
Xing, Naiguo
Shangguan, Yan
Zheng, Deping
Chen, Fanglu
Abrégé
The present invention relates to the field of pharmaceutical chemistry, and particularly to a crystal form of Abiraterone propionate and a preparation method therefor. Characteristic diffraction peaks occur at positions, where the 2θ value is 5.7°, 11.9°, 12.4°, 14.9°, 15.8°, 16.7°, 18.5°, 19.1°, 21.7°, 22.4°, and 39.9°±0.2°, in an X-ray powder diffraction spectrum of the crystal form of Abiraterone propionate.
C07J 43/00 - Stéroïdes normaux ayant un hétérocycle contenant de l'azote non condensé ou condensé en spiro avec le squelette du cyclopenta[a]hydrophénanthrène
A61K 31/58 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes contenant des hétérocycles, p. ex. danazol, stanozolol, pancuronium ou digitogénine
A handheld device (100) for supplying at least inspiratory gas pressure to a patient (101), comprising a gas flow generator (110) adapted to generate a gas flow to the patient (101) via a patient gas outlet portion (120) of the handheld device (100) such that a predetermined inspiratory gas pressure at an end (121) of the patient gas outlet portion (120) is obtained. The handheld device enables a user to easily carry and use the handheld device to receive inspiratory gas in an easy manner.
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
Produits et services
Sales promotion services for third parties; commercial
administration of the licensing of the goods and services of
others; presentation of goods on communication media, for
retail purposes. Medicinal materials processing; processing of chemical
reagents.
46.
System and method for synchronization of breathing in a mechanical ventilator
Example embodiments presented herein are directed towards a system, and corresponding method, for providing ventilation synchronization between breathing gas supplied by a mechanical ventilator and the breathing needs of a patient. In providing the ventilation synchronization, a total amount of energy required during an inspiratory phase of breathing is calculated. Based on the calculated energy, a decay factor is determined. The decay factor is supplied to an inspiratory triggering system in order to provide the ventilation synchronization.
A61B 5/113 - Mesure du mouvement du corps entier ou de parties de celui-ci, p. ex. tremblement de la tête ou des mains ou mobilité d'un membre se produisant au cours de la respiration
A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
A61M 16/00 - Dispositifs pour agir sur le système respiratoire des patients par un traitement au gaz, p. ex. ventilateursTubes trachéaux
A61M 16/10 - Préparation de gaz ou vapeurs à respirer
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
Produits et services
Sales promotion services for third parties; business assistance, advisory and consulting services in the field of commercial administration of the licensing of the goods and services of others; presentation of goods on all forms of media communications stations, systems, networks, and services for the purpose of promoting the goods and services of others Medicinal materials processing, comprising slicing, steaming and soaking of medicinal materials; processing of chemical reagents used for preparation, production and application guidance of polymerace chain reaction (PCR) agents for testing of samples such as serum, sputum and secretions as well as for preparation, production and application guidance of biochemical agents used in testing of samples such as blood and body fluids
A turbulator adapted to be mounted to or inserted in an inlet portion of a flow meter for a ventilator is disclosed. The turbulator is adapted to create a turbulent gas flow in the inlet portion downstream of the turbulator upon passage of a gas flow therethrough. A flow meter for a ventilator is provided. The flow meter may comprise such turbulator. The turbulator may be arranged in the inlet portion of the flow meter. A membrane for a ventilator flow meter is provided, as well as a flow meter comprising the membrane. A flow meter comprising a turbulator and a membrane is disclosed.
G01F 15/00 - Détails des appareils des groupes ou accessoires pour ces derniers, dans la mesure où de tels accessoires ou détails ne sont pas adaptés à ces types particuliers d'appareils, p. ex. pour l'indication à distance
A turbulator adapted to be mounted to or inserted in an inlet portion of a flow meter for a ventilator is disclosed. The turbulator is adapted to create a turbulent gas flow in the inlet portion downstream of the turbulator upon passage of a gas flow therethrough. A flow meter for a ventilator is provided. The flow meter may comprise such turbulator. The turbulator may be arranged in the inlet portion of the flow meter. A membrane for a ventilator flow meter is provided, as well as a flow meter comprising the membrane. A flow meter comprising a turbulator and a membrane is disclosed.
G01F 15/00 - Détails des appareils des groupes ou accessoires pour ces derniers, dans la mesure où de tels accessoires ou détails ne sont pas adaptés à ces types particuliers d'appareils, p. ex. pour l'indication à distance
50.
QUINOLINE DERIVATES, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE CO.,LTD (Chine)
Inventeur(s)
Deng, Jie
Lei, Huangshu
Wang, Weibo
Liu, Caiping
Ye, Wenrun
Xu, Liyan
Zhou, Changbing
Zhang, Guoyao
Zou, Yanye
He, Zhiqin
Abrégé
The present invention belongs to the technical field of pharmaceutical chemistry. Disclosed are quinoline derivates, preparation method therefor, and application thereof. Compounds provided by the present invention are the compounds represented by formula I or optical isomers, racemates, diastereoisomers, pharmaceutically acceptable salts or solvates thereof. The compounds have a significant killing effect on Mycobacterium tuberculosis, and can be used to prepare medicines for treating or preventing diseases or symptoms caused by the infection of Mycobacterium tuberculosis.
C07D 401/06 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne carbonée contenant uniquement des atomes de carbone aliphatiques
A61K 31/4709 - Quinoléines non condensées contenant d'autres hétérocycles
A61P 31/06 - Agents antibactériens pour le traitement de la tuberculose
C07D 207/08 - Composés hétérocycliques contenant des cycles à cinq chaînons, non condensés avec d'autres cycles, ne comportant qu'un atome d'azote comme unique hétéro-atome du cycle avec uniquement des atomes d'hydrogène ou de carbone liés directement à l'atome d'azote du cycle ne comportant pas de liaison double entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec des radicaux hydrocarbonés, substitués par des hétéro-atomes, liés aux atomes de carbone du cycle
C07D 211/32 - Composés hétérocycliques contenant des cycles pyridiques hydrogénés, non condensés avec d'autres cycles avec uniquement des atomes d'hydrogène et de carbone liés directement à l'atome d'azote du cycle ne comportant pas de liaison double entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec des radicaux hydrocarbonés ou des radicaux hydrocarbonés substitués, liés directement aux atomes de carbone du cycle avec des radicaux hydrocarbonés substitués liés aux atomes de carbone du cycle avec des radicaux hydrocarbonés, substitués par des atomes d'oxygène ou de soufre liés par des liaisons doubles ou par deux atomes d'oxygène ou de soufre, liés au même atome de carbone par des liaisons simples par des atomes d'oxygène
51.
A SYSTEM AND METHOD FOR SYNCHRONIZATION OF BREATHING IN A MECHANICAL VENTILATOR
Example embodiments presented herein are directed towards a system, and corresponding method, for providing ventilation synchronization between breathing gas supplied by a mechanical ventilator and the breathing needs of a patient. In providing the ventilation synchronization, a total amount of energy required during an inspiratory phase of breathing is calculated. Based on the calculated energy, a decay factor is determined. The decay factor is supplied to an inspiratory triggering system in order to provide the ventilation synchronization.
09 - Appareils et instruments scientifiques et électriques
Produits et services
Apparatus and instruments for conducting, switching, transforming, regulating or controlling electricity, excluding machines for the metallurgical industry and machines for the steel making industry
CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD (Chine)
Inventeur(s)
Wang, Li
Zhang, Tao
Deng, Jie
Abrégé
A stable oral solid drug composition of abiraterone comprises abiraterone acetate and citrate which serves as a pharmaceutical adjuvant, wherein the weight ratio of citrate to abiraterone acetate is 1:100 to 1:5.
A61K 31/58 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes contenant des hétérocycles, p. ex. danazol, stanozolol, pancuronium ou digitogénine
A61K 47/12 - Acides carboxyliquesLeurs sels ou anhydrides
Chongqing Pharmaceutical Research Institute Co., Ltd. (Chine)
Inventeur(s)
Lin, Jialiang
Deng, Jie
Chen, Hao
Zhang, Tao
Abrégé
The present invention provides a stable composition of rasagiline comprising an effective dosage of rasagiline or its pharmaceutically acceptable salts and an antioxidant used as a stabilizer. The dosage forms of the composition are pharmaceutically common transdermal-drug delivery dosage form and mucoadhesive delivery dosage form, such as patch, gel, ointment, cream, cataplasm, film, spray and solution, etc. The composition can be used to prevent or treat mental disorders.
CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD (Chine)
Inventeur(s)
Lin, Jialiang
Chen, Hao
Liu, Zerong
Fan, Bin
Zhang, Tao
Deng, Jie
Abrégé
A transdermal patch of Rasagiline comprises Rasagiline or pharmaceutically acceptable salts thereof, a base substance and an inert back layer. The oxygen transmissivity of the back layer is not more than 100 cm3 /m2 /24h，which can effectively reduce the volatilization of the Rasagiline from the back layer which results in decreased content, thus a long term sustained treatment effect is ensured.
A61K 31/135 - Amines, p. ex. amantadine ayant des cycles aromatiques, p. ex. méthadone
A61K 47/32 - Composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. carbomères
A61K 47/34 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyesters, acides polyaminés, polysiloxanes, polyphosphazines, copolymères de polyalkylène glycol ou de poloxamères
A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
57.
PREPARATION METHOD FOR MORPHINAN BROMIDE QUATERNARY AMMONIUM SALT
CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD (Chine)
Inventeur(s)
Sun, Huafu
Dan, Chunyan
Luo, Jie
Ye, Wenrun
Lin, Bo
Zhang, Daolin
Liao, Wei
Abrégé
Disclosed is a preparation method for a morphinan bromide quaternary ammonium salt as represented by Formula (I). The method comprises: transforming a compound as represented by Formula (II) in a compound as represented by Formula (I) by an ion-exchange using a brominated strongly basic anion-exchange resin. The definitions of A, R1, R1 and X- found in Formula (I) and Formula (II) are as presented in the description.
Chongqing Pharmaceutical Research Institute Co., Ltd. (Chine)
Inventeur(s)
Luo, Jie
Lin, Meng
Zhu, Zhengyong
Luo, Junlai
Ye, Wenrun
Qin, Yongmei
Deng, Jie
Abrégé
Three new crystalline forms of pemetrexed diacid, preparation methods and uses thereof are disclosed. These preparation processes are simple and have better practicality.
CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD (Chine)
Inventeur(s)
Zhou, Xingguo
Tang, Xuemin
Ye, Wenrun
Luo, Jie
Deng, Jie
Abrégé
A preparation method of ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl-5-thiazolecarboxylate as a key intermediate of febuxostat is provided. The preparation method comprises: using thioacetamide and p-cyanophenol as raw materials which are reacted in an acid aqueous solution to obtain 4-hydroxy thiobenzamide, and reacting 4-hydroxy thiobenzamide with ethyl 2- chloroacetoacetate to obtain ethyl 2-(4-hydroxyphenyl)-4-methyl-5-thiazolecarboxylate, and reacting the obtained compound with methenamine in the presence of polyphosphoric acid and methanesulfonic acid to obtain ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl-5-thiazolecarboxylate.
C07C 237/48 - Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des groupes amino ayant l'atome de carbone d'au moins l'un des groupes carboxamide lié à un atome de carbone d'un cycle aromatique à six chaînons faisant partie d'un système cyclique condensé du même squelette carboné
C07D 277/56 - Atomes de carbone comportant trois liaisons à des hétéro-atomes avec au plus une liaison à un halogène
CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD. (Chine)
Inventeur(s)
Lin, Jialiang
Deng, Jie
Chen, Hao
Zhang, Tao
Abrégé
The present invention provides a stable composition of rasagiline comprising an effective dosage of rasagiline or its pharmaceutically acceptable salts and an antioxidant used as a stabilizer. The dosage forms of the composition are pharmaceutically common transdermal-drug delivery dosage form and mucoadhesive delivery dosage form, such as patch, gel, ointment, cream, cataplasm, film, spray and solution, etc. The composition can be used to prevent or treat mental disorders.
CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD. (Chine)
Inventeur(s)
Lin, Jialiang
Deng, Jie
Chen, Hao
Zhang, Tao
Abrégé
The present invention provides a stable composition of rasagiline comprising an effective dosage of rasagiline or its pharmaceutically acceptable salts and antioxidant used as stabilizer. The dosage forms of the composition are pharmaceutically common transdermal-drug delivery dosage form and mucoadhesive delivery dosage form, such as patch, gel, ointment, cream, cataplasm, film agent, spraying agent and solution etc. The composition can be used to prevent or treat mental disorders.
CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD. (Chine)
Inventeur(s)
Lin, Meng
Luo, Junlai
Luo, Bin
Jiang, Yong
Luo, Jie
Ye, Wenrun
Abrégé
Three new crystalline forms of Agomelatine, their preparation methods and the pharmaceutical compositions containing them and their preparation use of drug used for curing the diseases of central nervous system are provided. These three new crystalline forms of Agomelatine have the advantage of high stability and easy preparation and are suitable for the production of pharmaceutical preparation.
C07C 233/18 - Amides d'acides carboxyliques ayant des atomes de carbone de groupes carboxamide liés à des atomes d'hydrogène ou à des atomes de carbone acycliques ayant l'atome d'azote d'au moins un des groupes carboxamide lié à un atome de carbone d'un radical hydrocarboné substitué par des atomes d'oxygène liés par des liaisons simples avec le radical hydrocarboné substitué lié à l'atome d'azote du groupe carboxamide par un atome de carbone acyclique ayant l'atome de carbone du groupe carboxamide lié à un atome d'hydrogène ou à un atome de carbone d'un squelette carboné acyclique saturé
A61K 31/165 - Amides, p. ex. acides hydroxamiques ayant des cycles aromatiques, p. ex. colchicine, aténolol, progabide
A61P 5/00 - Médicaments pour le traitement des troubles du système endocrinien
A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
A61P 25/18 - Antipsychotiques, c.-à-d. neuroleptiquesMédicaments pour le traitement de la manie ou de la schizophrénie
CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD. (Chine)
Inventeur(s)
Xie, Feng
Xing, Naiguo
Zhang, Wei
Gong, Hengyuan
Liu, Zerong
Deng, Jie
Luo, Jie
Ye, Wenrun
Fan, Bin
Abrégé
High purified (2β,3α,5α,16β,17β) -2-(4-morpholinyl)-16-(1-pyrrolidinyl)-androstane-3,17-diol (formula III) or composition containing it and their use in preparing rocuronium bromide (formula I) are disclosed.
C07J 43/00 - Stéroïdes normaux ayant un hétérocycle contenant de l'azote non condensé ou condensé en spiro avec le squelette du cyclopenta[a]hydrophénanthrène
A61P 21/02 - Relaxants musculaires, p. ex. pour la tétanie ou les crampes
65.
HIGH-PURITY FEBUXOSTAT AND THE METHOD FOR PREPARATION
CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD (Chine)
Inventeur(s)
Zhou, Xingguo
Tang, Xuemin
Shi, Ruina
Ye, Wenrun
Luo, Jie
Deng, Jie
Fan, Bin
Abrégé
A febuxostat which purity is no less than 99.0％, method for preparation thereof, and pharmaceutical composition thereof. The said method for preparation includes recrystalling febuxostat in mixed solvent. The said pharmaceutical composition can be used in manufacture of medicaments for treating diseases associated with hyperuricemia.
CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD. (Chine)
Inventeur(s)
Luo, Jie
Lin, Meng
Zhu, Zhengyong
Luo, Junlai
Ye, Wenrun
Qin, Yongmei
Deng, Jie
Abrégé
Three new crystalline forms of pemetrexed diacid, preparation methods and uses thereof. These preparation processes are simple and have better practicality.
CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD (Chine)
Inventeur(s)
Sun, Huafu
Luo, Jie
Ye, Wenrun
Deng, Jie
Lin, Bo
Dan, Chunyan
Fan, Bin
Abrégé
The invention discloses morphinan derivatives and their preparation method, especially discloses ketal hydroxyl protected compounds of morphinan derivatives and their preparation method, and the method for preparing corresponding alkylated morphinan derivatives using the said ketal hydroxyl protected compounds as intermediates, and more especially discloses ketal hydroxyl protected compound intermediates of methylnaltrexone for preparing methylnaltrexone and the method for preparing methylnaltrexone through said intermediates.
C07D 489/09 - Composés hétérocycliques contenant des systèmes cycliques 4 aH-8, 9 c-imino-éthano-phénantro [4, 5-b, c, d] furanne, p. ex. dérivés d'époxy-4, 5 morphinane de formule contenant des systèmes cycliques 4 aH-8, 9 c-imino-éthano-phénantro [4, 5-b, c, d] furanne condensés avec des carbocycles ou avec des systèmes carbocycliques
68.
A STABLE AND RELEASE-CONTROLLED RASAGILINE TRANSDERMAL PATCH AND METHOD OF PREPARATION THEREOF
CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD (Chine)
Inventeur(s)
Lin, Jialiang
Li, Qun
Li, Hongzhong
Zhang, Tao
Deng, Jie
Fan, Bin
Abrégé
A transdermal patch of rasagiline or pharmaceutically acceptable salts thereof for treating or preventing nervous system diseases. Particularly, a stable and release-controlled transdermal patch of rasagiline is provided, wherein the patch contains rasagiline or pharmaceutically acceptable salts thereof and at least one hydrophilic polymer matrix, moreover, the pH value of the patch is less than 7.0. The patch has predominant stability and can well control the transdermal release characteristics of rasageline.
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes
The present invention relates to a solution for controlling the pressure/flow of breathing gas to a mechanical ventilator (4) by using an energy of breathing analysis and further to provide a pressure relief during exhalation and a trigger determination when to start the pressure relief using energy content of breathing in analysis for determining a pressure curve form during at least a portion of the expiration phase.
F16K 31/02 - Moyens de fonctionnementDispositifs de retour à la position de repos électriquesMoyens de fonctionnementDispositifs de retour à la position de repos magnétiques
A61M 16/06 - Masques respiratoires ou pour l'anesthésie
70.
PURIFICATION METHOD OF PEMETREXED SALTS,SODIUM SALTS AND DISODIUM SALTS
CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD. (Chine)
Inventeur(s)
Luo, Jie
Lin, Meng
Lin, Bo
Ye, Wenrun
Qin, Yongmei
Deng, Jie
Abrégé
A purification method of pemetrexed salts by means of salting-out. The pemetrexed salts are defined as formula (III) in which, (1) If M3+ is H+, then M1+ and M2+ are H+, Li+, Na+ or K+ independently. M1+ and M2+ are the same or not ,but they can not be H+ simultaneously; (2)If M3+ is Li+, Na+ or K+, then M1+ and M2+ are Li+, Na+ or K+ independently. M1+, M2+ and M3+ are the same or not.
CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD. (Chine)
Inventeur(s)
Zhang, Tao
Li, Jia
Zou, Yanye
Mu, Caihua
Fan, Bin
Abrégé
The medicine composition containing abafungin is provided in the present invention, and the said composition contains abafungin and other antibacterial agents. The use of the said medicine composition for treating fungus infections or fungus and bacteria mixed infections is also provided in the present invention.
A61K 31/506 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime non condensées et contenant d'autres hétérocycles
A61K 31/43 - Composés contenant des systèmes cycliques thia-4 aza-1 bicyclo [3.2.0] heptane, c.-à-d. composés contenant un système cyclique de formule , p. ex. pénicillines, pénèmes
A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p. ex. rifampine, thiothixène ou sparfloxacine
A61K 31/545 - Composés contenant des systèmes cycliques thia-5 aza-1 bicyclo [4.2.0] octane, c.-à-d. composés contenant un système cyclique de formule , p. ex. céphalosporines, céfaclor, céphalexine
A61K 31/635 - Composés contenant des groupes para-N-benzènesulfonyl-N-, p. ex. sulfanilamide, p-nitrobenzènesulfonohydrazide contenant un hétérocycle, p. ex. sulfadiazine
A61K 31/7034 - Composés ayant des radicaux saccharide liés à des composés non-saccharide par des liaisons glycosidiques liés à un composé carbocyclique, p. ex. phloridzine
A61K 31/498 - Pyrazines ou pipérazines condensées en ortho ou en péri avec des systèmes carbocycliques, p. ex. quinoxaline, phénazine
A61K 31/7036 - Composés ayant des radicaux saccharide liés à des composés non-saccharide par des liaisons glycosidiques liés à un composé carbocyclique, p. ex. phloridzine ayant au moins un groupe amino lié directement au carbocycle, p. ex. streptomycine, gentamycine, amikacine, validamycine, fortimicines
A61K 31/7056 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p. ex. nucléosides, nucléotides contenant des cycles à cinq chaînons avec l'azote comme hétéro-atome d'un cycle
A61K 31/7048 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'oxygène comme hétéro-atome d'un cycle, p. ex. leucoglucosane, hespéridine, érythromycine, nystatine
A method and apparatus for facilitating breathing using a mechanical breathing gas ventilator is presented. The patient effort is deduced from a measured flow signal and analyzed with respect to the energy in the breathing system comprising the mechanical ventilator and the patient. When a predetermined energy threshold has been reached the ventilator responds to the breathing pattern change.
CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD. (Chine)
Inventeur(s)
Luo, Jie
Lin, Bo
Ye, Wenrun
Abrégé
The invention provides preparation method of thioureas or salts thereof. In particular, the invention provides method of preparing thioureas by reacting cyanamides or salts thereof with thioamides in proper acidic medium. The product can be used to prepare 2-aminothiazoles, such as antimycotic abafungin.
C07D 417/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 239/16 - Atomes d'azote ne faisant pas partie d'un radical nitro acylés sur lesdits atomes d'azote
CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD. (Chine)
Inventeur(s)
Zhou, Xingguo
Tang, Xuemin
Deng, Jie
Ye, Wenrun
Luo, Jie
Zhang, Daolin
Fan, Bin
Abrégé
The present application belongs to pharmaceutical technology field. Three new crystal types of 2-(3-cyano-4-isobutyloxy) phenyl-4-methyl-5-thiazolecarboxylic acid (febuxostat) i.e. crystal types H, I and J and their preparation methods. Pharmaceutical compositions containing the new crystal types and the uses of crystal types as pharmaceutical medicaments for treatment diseases relating to excessive uric acid. Furthermore, the present application discloses X-ray diffraction characteristic absorption peak and IR absorption peak.
CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD. (Chine)
Inventeur(s)
Zhang, Tao
Wang, Hui
Li, Jia
Mu, Caihua
Fan, Bin
Chen, Weihai
Abrégé
An antimycotic pharmaceutical composition comprising the 2-aminothiazoles of the general formula (I) and corticoid drugs and the use of which for the treatment or prevention skin infection caused by fungus, wherein the definition of substituent group of general formula (I) as described in the description. Particularly, the antimycotic pharmaceutical composition can be used to treat or prevent skin infection caused by fungus, superficial fungal diseases, itching, the mixed infection caused by fungus and bacterium or various dermatitis
A61K 31/506 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime non condensées et contenant d'autres hétérocycles
A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone substitués en position 21, p. ex. cortisone, dexaméthasone, prednisone ou aldostérone
A61K 31/58 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes contenant des hétérocycles, p. ex. danazol, stanozolol, pancuronium ou digitogénine
A61K 31/57 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 31/7036 - Composés ayant des radicaux saccharide liés à des composés non-saccharide par des liaisons glycosidiques liés à un composé carbocyclique, p. ex. phloridzine ayant au moins un groupe amino lié directement au carbocycle, p. ex. streptomycine, gentamycine, amikacine, validamycine, fortimicines
A61K 31/7056 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p. ex. nucléosides, nucléotides contenant des cycles à cinq chaînons avec l'azote comme hétéro-atome d'un cycle
A61K 31/5383 - 1,4-Oxazines, p. ex. morpholine condensées en ortho ou en péri avec des systèmes hétérocycliques
A61K 31/351 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à six chaînons avec un oxygène comme seul hétéro-atome d'un cycle non condensés avec un autre cycle
The present invention relates to a solution for controlling the pressure/flow of breathing gas to a mechanical ventilator (4) by using an energy of breathing analysis and further to provide a pressure relief during exhalation and a trigger determination when to start the pressure relief using energy content of breathing in analysis for determining a pressure curve form during at least a portion of the expiration phase.
A transdermal patch of rasagiline for treatment or prophylaxis of nervous system disease and its preparation process, comprises: a backing layer inert to the components of the matrix a matrix layer contg. rasagiline and its or its salt, and a removable protective layer, characterised in that the matrix is an adhesive system having distribured therein as polymer and organic or inorganic bulking agent and dermal penetration enhancer, the reservoir in the matrix layer contains rasagiline, said polymer is based on organic macromolecular material and useful as the active substance reservoir and adhesive.
CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD. (Chine)
Inventeur(s)
Xiao, Jinmai
Deng, Jie
Xiao, Bo
Feng, Jin
Abrégé
The present invention discloses a new pharmaceutical composition comprising, in well-distributed powder form : iron-saccharide complex and salt agent in a suitable amount or other excipient . It also discloses the process for preparation the composition , wherein the salt or other excipient is added before iron-saccharide complex is being dried . This improved process make API manufacturer prepare the hematinic powder which can be used just mixed with water , moreover , the powder is easy to reconstitute in water by the ordinary manufacturer .
A61K 31/7012 - Composés ayant un groupe carboxyle libre ou estérifié, lié directement ou par une chaîne carbonée, à un atome de carbone du radical saccharide, p. ex. acide glucuronique, acide neuraminique
A61K 31/555 - Composés hétérocycliques contenant des métaux lourds, p. ex. hémine, hématine, mélarsoprol
A pharmaceutical composition for treating gout and its application in preparation of medicines for treating gout are provided. The said pharmaceutical composition comprises effective amount of febuxostat or its pharmaceutical salts or its solvates and a uric acid eliminant.
A ventilator apparatus, method, system, and computer program for determining leakage in a flow circuit providing pressurized gas to a patient having breathing disorder. The present invention determines the leakage by calculating a ratio between a measured flow of gas and a determined flow of gas related to a standard leakage. The determined standard leak flow may be calculated from a formula derived from Bernoulli's theorem. The invention may further be arranged to use a volume difference between inspiration and expiration phases in the compensation process.
CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD. (Chine)
Inventeur(s)
Xiao, Jinmai
Deng, Jie
Feng, Jinhua
Xiao, Bo
Abrégé
The invention discloses a process for preparing multinuclear ferric hydroxide-saccharidic complexes, comprising: titrating an aqueous solution of iron salt with an aqueous solution of alkali to a final pH of 68 under 520 , collecting the multinuclear ferric hydroxide from the reaction product by conventional method; maintaining a reaction mixture of multinuclear ferric hydroxide, saccharides and solution of alkali for 1040 hours under a temperature of 106125 and pH being 1012, and obtaining the crude product having an isoelectric point of 4.45.3 and a weight average molecular weight of 20000100000 Daltons, and then collecting the multinuclear ferric hydroxide-saccharidic complexes from the crude product. The process can control the molecular weight of the multinuclear ferric hydroxide-saccharidic complexes exactly while not influencing other characteristics of the product such as content of saccharides or isoelectric point etc, and which is simple and readily applicable in industry.
A61K 31/715 - Polysaccharides, c.-à-d. ayant plus de cinq radicaux saccharide liés les uns aux autres par des liaisons glycosidiquesLeurs dérivés, p. ex. éthers, esters
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
Produits et services
Medical paste; chemico-pharmaceutical preparations;
medicines for human purposes; dressings (medical); tissue
paper impregnated with disinfectants; teeth filling
material; medicinal drinks; adhesive tapes for medical
purposes; dietetic food preparations adapted for medical
purposes; solutions for contact lenses. Dental apparatus; hearing aids for the deaf;
contraceptives, non-chemical; surgical implants; orthopedic
articles; suture materials; furniture especially made for
medical purposes; medical apparatus and instruments. Processing of medicinal materials; processing and handling
of chemical reagents.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
(1) Surgical and topical anaesthetics; analgesics; antipyretics; non-steroidal anti-inflammatory medicines; medicines used to treat gout; medicines used to treat disease modifying agents in rheumatoid disorders;antiallergics; medicine used in anaphylaxis; antidotes to counteract poisons; anticonvulsants; anti-epileptics; anti-infectives; anti-migraine medicine; anti-neoplastic; immunosuppressives used in palliative care; pharmaceutical preparations for the treatment of the central nervous system, namely, encephalitis, epilepsy, Alzheimer's, cerebral palsy, Parkinson's disease; herbal supplements and pharmaceutical preparations for the treatment of cardiovascular diseases; pharmaceutical preparations for use in dermatology, namely, dermatitis, skin pigmentation diseases, sexually transmitted diseases; pharmaceutical preparations for the treatment of genitourinary diseases, namely, urological diseases, infertility, sexually transmitted diseases, inflammatory pelvic diseases; pharmaceutical preparations for the treatment of gastrointestinal diseases; hormones for humans, namely, human growth hormones, hormone replacement therapy preparations; contraceptives, namely, condoms, diaphragms, foams, oral, sponges, spermicides; opthalmological preparations; medicine acting on the respiratory tract; vitamins; minerals; PCR reagent used to test sputum; PCR reagent used in the hepatis; PCR reagent used in respiratory disease; PCR reagent used in venereal disease; PCR reagent used in bacterial disease; chemical preparations used to test blood; chemical preparations used to test sputum; pharmaceutical preparations for the treatment of blood disorders, the treatment of cancer, headaches, headaches, immunologic diseases, namely, autoimmune diseases, immunologic deficiency syndromes, infectious diseases, namely, respiratory infections, eye infections, inflammatory diseases, namely, inflammatory bowel diseases, inflammatory connective tissue diseases, psychiatric diseases, namely, mood disorders, anxiety disorders, cognitive disorders, the musculoskeletal system, namely, connective tissue disorders, bone diseases, spinal diseases, back pain, fractures, sprains, cartilage injuries, the respiratory system; pharmaceutical preparations for use in gastroenterology.
medical apparatus and instruments, namely, medical respiratory apparatus to enhance breathing; and sleep screening apparatus and accessories thereto for use with medical respiratory apparatus and with sleep screening apparatus, namely remote controls, remote alarms and nasal masks
