Abstract

A variable-rigidity vascular intervention catheter and a manufacturing method therefor. The variable-rigidity vascular intervention catheter comprises an outer-layer guide tube and an inner-layer guide tube, a working channel being formed inside the inner-layer guide tube, and a low-melting-point alloy having a melting point of 43-45°C being sealed between the outer-layer guide tube and the inner-layer guide tube. The rigidity of the variable-rigidity vascular intervention catheter can be adjusted by means of injecting into the working channel normal saline having different temperatures, so as to adapt to different operations during surgeries, thus facilitating normal operation of surgeries.

IPC Classes  ?

• A61M 25/00 - CathetersHollow probes
• A61M 25/01 - Introducing, guiding, advancing, emplacing or holding catheters
• A61M 25/16 - Making or assembling not otherwise provided for

Abstract

The present invention relates to the technical field of negative electrode materials for quick charging of secondary batteries, and provides a black phosphorus-carbon-nitrogen composite negative electrode material and a preparation method therefor. The preparation method for the black phosphorus-carbon-nitrogen composite negative electrode material comprises the following steps: S1: placing black phosphorus, a carbon material, and an alkaline nitrogen-containing compound in a ball milling tank in an atmosphere of nitrogen or argon, and adding grinding balls at the same time; and S2: carrying out mixed ball milling at a rotating speed of 100-600 rpm for 1-72 h to obtain the black phosphorus-carbon-nitrogen composite negative electrode material. According to the preparation method for the black phosphorus-carbon-nitrogen composite negative electrode material provided by the present invention, the reconstruction and hybridization processes of phosphorus atoms at the edge of the activated black phosphorus can be accelerated, facilitating phosphorus-carbon-nitrogen bonding. Due to the improvement of the uniform hybridization degree of black phosphorus, the particle size of the obtained black phosphorus-carbon-nitrogen composite negative electrode material is more uniform, effectively solving the problem of non-uniform material size obtained by conventional ball milling. A fast lithium ion conductor can be formed during electrochemical reaction of nitrogen, and with a good conductive channel in the material, a quick charging process is implemented.

IPC Classes  ?

• H01M 4/38 - Selection of substances as active materials, active masses, active liquids of elements or alloys

Abstract

Disclosed is a long text matching method combining noise filtering and a divide-and-conquer strategy. The method comprises: constructing a long text matching model, which comprises a keyword extraction layer, an association extraction layer and a filtering layer, wherein the keyword extraction layer is used for extracting keywords in texts, the filtering layer is used for filtering noise in the texts on the basis of the similarity between sentences to obtain a denoised text sequence, and the association extraction layer is used for removing the keywords from the denoised text sequence to obtain the remaining associated texts; taking minimization of a set overall loss function as an optimization target to train the long text matching model, wherein the loss function reflects global matching distribution and combines the keywords with associated matching distribution; and for a target text, using the trained long text matching model to perform real-time text matching. The present invention improves the generalization ability and accuracy of text matching.

IPC Classes  ?

• G06F 16/33 - Querying

Abstract

Disclosed is an attention mechanism-supporting accelerator, used for implementing a matrix multiplication operation, a scaling operation, or nonlinear activation processing involved in an attention mechanism. A weight cache state machine module is used for controlling the flow of weight data from a system bus to a weight cache unit. A thread cache state machine module is used for controlling the flow of thread data from the system bus to a thread cache unit. An attention tensor processing unit state machine module is used for controlling the loading and flow of the thread data and the weight data from different directions into a two-dimensional systolic array. The thread data is controlled to be delivered to the next processing unit in each period, and the weight data is propagated to each processing unit in a corresponding direction in the form of broadcasting. A computation result of the two-dimensional systolic array is delivered to different branches on the basis of whether nonlinear activation processing needs to be executed. According to the present invention, data padding is performed on a matrix so that the matrix is aligned with the systolic array data flow, thereby accelerating an attention mechanism having a variable sequence length by using hardware.

IPC Classes  ?

• G06F 30/32 - Circuit design at the digital level

Abstract

The present application relates to a brain glioma typing prediction method and apparatus, a computer device, and a storage medium. The method comprises: collecting a whole slide image of a tumor patient, and performing patch cutting on the whole slide image to generate patch images; extracting deep feature vectors of the patch images, clustering the deep feature vectors, and grouping the patch images to obtain a set number of patch groups; using all the patch images as a reference data set for training to obtain a reference prediction model, and using patch images in each patch group as a non-reference data set for training to obtain a non-reference prediction model; and screening for a patch group corresponding to the non-reference prediction model of which the accuracy is higher than reference precision, and using the selected patch group for training to obtain a brain glioma typing prediction model. According to embodiments of the present application, the model prediction precision can be ensured, and the model generalization performance can be improved.

IPC Classes  ?

• G06T 7/00 - Image analysis
• G06T 7/136 - SegmentationEdge detection involving thresholding

Abstract

Provided are a controllable gradient scaffold preparation method and a controllable gradient scaffold. Cells are modified by means of mRNA delivery, and the modified cells are loaded to a specific position to construct a gradient scaffold. The controllable gradient scaffold preparation method relates to functionalizing seed cells by means of mRNA transfection, and thus achieves better effectiveness, safety and clinical translation potential than traditional methods involving recombinant proteins, plasmids, metal ions, etc. In addition, the used mRNA is highly designable, such that on the basis of the regeneration needs of different tissues, functional factors required for encoding can be designed, to design specific shapes and internal structures to satisfy clinical needs, thereby achieving personalized structural customization and better satisfying the needs of accurately inducing trilineage differentiation of BMSCs to cartilage, hypertrophic cartilage and bone within a three-dimensional space of the scaffold.

IPC Classes  ?

• C12N 15/88 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using liposome vesicle
• C12N 15/87 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
• C12N 15/12 - Genes encoding animal proteins
• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
• A61F 2/28 - Bones
• A61L 27/24 - Collagen
• A61L 27/22 - Polypeptides or derivatives thereof
• A61L 27/38 - Animal cells
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 80/00 - Products made by additive manufacturing

Abstract

The embodiments of the present invention relate to the technical field of image processing. Disclosed are a color video generation method and apparatus, and an electronic device and a storage medium. The method comprises: acquiring a video to be processed, wherein the video to be processed comprises at least one depth map; for each depth map, performing noise diffusion on the depth map by means of a diffusion model, so as to obtain a noise map corresponding to the depth map, wherein the noise map is used for indicating semantic information and depth information of the depth map; and inputting the video to be processed into a color video generation model to generate a corresponding color video, and introducing the noise map that has been encoded by a noise encoder to perform global semantic control on a color video generation process, so as to obtain the color video, wherein the color video comprises at least one color map, and each color map corresponds to one depth map in the video to be processed. The present invention solves the problems in the prior art of the cost being relatively high and the color video generation accuracy being not high.

IPC Classes  ?

• H04N 9/64 - Circuits for processing colour signals

Abstract

Disclosed in the present invention are a composite current collector and a preparation method therefor and the use thereof. The composite current collector comprises a substrate layer, a transition layer, an electrically conductive layer, a columnar porous array layer, a metal replenishment layer, and a surface coating layer, which are sequentially stacked, wherein the columnar porous array layer is formed by means of a metal column array; and the material of the metal replenishment layer is selected from a lithium alloy, a sodium alloy, or a potassium alloy. In the composite current collector in the present invention, by means of providing the metal replenishment layer used for replenishing metal loss in a metal-ion battery cycle process, and due to the metal replenishment layer being present in the form of a metal alloy, metal oxidation can be avoided, and a metal preservation time can be prolonged, thereby achieving metal replenishment for the full life cycle of a metal-ion battery; and by means of providing the columnar porous array layer, a buffer space can be provided for thermal expansion in a metal-ion cycle process, thereby improving the first cycle coulombic efficiency and capacity retention of the battery, and prolonging the service life of the metal-ion battery.

IPC Classes  ?

• H01M 4/66 - Selection of materials
• H01M 4/80 - Porous plates, e.g. sintered carriers
• H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries
• C23C 14/35 - Sputtering by application of a magnetic field, e.g. magnetron sputtering
• C23C 14/24 - Vacuum evaporation
• C23C 14/20 - Metallic material, boron or silicon on organic substrates

Abstract

Provided are a recombinant pseudorabies virus for highly-sensitive expression of a red fluorescent protein, and a preparation therefor and a use thereof, specifically comprising: (1) constructing a recombinant plasmid to prepare the recombinant pseudorabies virus for highly-sensitive expression of the red fluorescent protein; and (2) a use in neural circuit tracing, wherein the recombinant pseudorabies virus for highly-sensitive expression of the red fluorescent protein prepared by a platform can achieve efficient retrograde trans-synaptic labeling of a neural network. The recombinant pseudorabies virus for highly-sensitive expression of the red fluorescent protein and for retrograde trans-synaptic labeling is successfully obtained, such that the problem of low red fluorescence expression efficiency in existing methods is solved, and the recombinant pseudorabies virus achieves high application value and wide market prospects in neural circuit structure and function analysis, vaccine and drug research and development, disease model establishment, detection of neural network loss and reconstruction, virus replication or pathogenic mechanism research, etc.

IPC Classes  ?

• C12N 7/01 - Viruses, e.g. bacteriophages, modified by introduction of foreign genetic material
• C12N 15/12 - Genes encoding animal proteins
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• G01N 21/64 - FluorescencePhosphorescence
• A61K 39/245 - Herpetoviridae, e.g. herpes simplex virus
• A61P 31/22 - Antivirals for DNA viruses for herpes viruses

Abstract

Provided in the present application are a perovskite solar cell and a preparation method therefor. Along the propagation path of light, the perovskite solar cell can be divided into a substrate, a transparent conductive layer, a hole transport layer, a light absorption layer, an electron transport layer, a hole blocking layer and a back electrode layer from bottom to top, wherein the hole transport layer is nickel oxide having a single or laminated structure prepared by means of a radio frequency magnetron sputtering method, a smooth and compact film is formed, and the hole transport layer has a uniform grain size and is tightly bonded to a substrate. The present invention can achieve extensive assembly-line production of hole transport layers in perovskite solar cells, overcomes limitations of solution methods such as a spin coating method on size, is simple in terms of process operation, high in terms of repeatability and suitable for large-scale production, and can greatly improve production efficiency.

IPC Classes  ?

• H10K 30/86 - Layers having high hole mobility, e.g. hole-transporting layers or electron-blocking layers
• H10K 99/00 - Subject matter not provided for in other groups of this subclass
• H10K 85/50 - Organic perovskitesHybrid organic-inorganic perovskites [HOIP], e.g. CH3NH3PbI3
• H10K 71/00 - Manufacture or treatment specially adapted for the organic devices covered by this subclass

Abstract

A visual SLAM-based path planning method and apparatus, an electronic device, and a storage medium. The method comprises: acquiring an offline map of a current scene, the offline map of the current scene being pre-constructed by means of an SLAM algorithm (S100); acquiring a current image frame by means of a camera, and performing ORB feature point extraction on the current image frame (S110); matching ORB feature points with the offline map of the current scene to obtain pose information of the camera (S120); performing target point detection on the current image frame by means of a deep learning model, and using pose transformation to calculate position coordinates of a target point (S130); taking the pose information of the camera as a path planning starting point, and taking the position coordinates of the target point as a path planning end point, using a path planning algorithm to perform path planning on the offline map (S140). According to the method, information of an offline map is fully used, feature points can be accurately matched with map points to obtain accurate pose information.

IPC Classes  ?

• G01C 21/34 - Route searchingRoute guidance

Abstract

A microfluidic chemiluminescence immunoassay system, and a test method and an application. The microfluidic chemiluminescence immunoassay system comprises a microfluidic immunoreactor (100), a pipette (200) and a chemiluminescence test unit (300), wherein the microfluidic immunoreactor (100) may be tightly attached to the pipette (200) and an adapter connected thereto, the pipette (200) may control a liquid that enters and exits the microfluidic immunoreactor (100), and the chemiluminescence test unit (300) may fix the pipette (200) and the microfluidic immunoreactor (100) attached thereto in a specified position, collect a chemiluminescence image signal, and also convert the chemiluminescence image signal into a quantitative numerical signal, so as to acquire a specific antibody binding ability of a virus strain and/or a neutralizing ability of the strain and/or the concentration of an immune response marker in fingertip blood. The microfluidic chemiluminescence immunoassay system has the advantages of a simple structure and being easy to carry, thereby facilitating deployment and usage in field or remote areas, and further has the advantage of acquiring, by means of a small amount of fingertip blood, a specific antibody binding ability of a strain and/or a neutralizing ability of the strain and/or the concentration of an immune response marker in blood.

IPC Classes  ?

• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

The present application relates to the technical field of magnetic resonance. Disclosed are a pulsed steady-state CEST signal reconstruction method and apparatus, a device, and a storage medium. The method comprises: normalizing a first CEST signal and a second CEST signal to obtain an apparent Z-spectrum signal; calculating the longitudinal relaxation rate of water; establishing a function relational expression between the apparent Z-spectrum signal and target parameters, the target parameters comprising the longitudinal relaxation rate of water, the duty cycle of a pulsed radiofrequency saturation pulse, a pulse duration, and a relaxation delay time; acquiring a target Z-spectrum signal according to the function relational expression; and quantitatively analyzing the target Z-spectrum signal. The present application can obtain as the target Z-spectrum signal a steady-state Z-spectrum signal at the maximum extreme values of the pulse duration and the relaxation delay time, so as to obtain a target CEST signal approaching an ideal steady-state CEST signal, reducing effects of insufficiently long pulse duration and relaxation delay time on CEST signal quantification, and enhancing the CEST imaging capability of clinical magnetic resonance imaging systems.

IPC Classes  ?

• G01R 33/56 - Image enhancement or correction, e.g. subtraction or averaging techniques

Abstract

A dual low-dose attenuation correction method for a PET/CT system, belonging to the field of medical positron emission tomography, and used to achieve the goal of reducing radiation dose while ensuring image quality of imaging. The technical solution is: performing multi-scale feature extraction on a low-dose ACCT image, to obtain a first feature map set {fjCTCT|j=1, 2, ..., N}, and performing multi-scale feature extraction on a low-dose non-attenuated PET image, to obtain a second feature map set {fjPETPET|j=1, 2, ..., N}, N being a set value; adaptively aligning spatial positions of the first feature map fjCTCT and the second feature map fjPETPET, and matching and fusing the two aligned feature maps, to obtain a third feature map set {fjCT-PETCT-PETCT-PET a number M of times, to obtain an attenuation-corrected feature map fNCT-PETCT-PET, M being a set value; enlarging the feature map fjAC-PETAC-PET to the same size as fj-1CT-PETCT-PET, and splicing fj-1CT-PETCT-PET ​​with fjAC-PETAC-PET, to obtain an attenuation-corrected feature map fj-1AC-PETAC-PET, j=N, ..., 2; on the basis of the feature map f1AC-PETAC-PET, obtaining a visible standard-dose PET image.

IPC Classes  ?

• A61B 6/03 - Computed tomography [CT]

Abstract

Embodiments of the present invention relate to the field of computer vision. Disclosed are an image processing method and apparatus. The method comprises: obtaining an image to be processed, and performing position detection and image segmentation on said image to obtain a segmented image of the image to be processed, wherein the segmented image is used for indicating an area to be processed in the image to be processed, and said area comprises a redundant mark to be removed; performing image processing on the segmented image to obtain a mask image, wherein an area to be processed in the mask image corresponds to the area to be processed in the segmented image; using a deep learning algorithm and an attention mechanism to perform feature extraction on the segmented image and the mask image to obtain an output image; and performing image fusion on the output image and the image to be processed to obtain a resultant image in which the redundant mark has been removed. The present invention solves the problems in the prior art of complex operation and poor image processing effect.

IPC Classes  ?

• G06V 30/148 - Segmentation of character regions
• G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects

Abstract

A definition and online monitoring method and system for an autonomous driving operational design domain (ODD). Taking a lane keeping function as an example, the method comprises: acquiring an observation data set, establishing a structure cause-and-effect diagram between lane line detection precision of an autonomous driving system and ODD elements on the basis of the observation data set, and fitting a structure cause-and-effect equation of the structure cause-and-effect diagram on the basis of an observation sample; acquiring various operating environment combinations on the basis of an operating parameter space of an autonomous vehicle, applying the acquired structure cause-and-effect equation to perform counterfactual reasoning on an autonomous driving performance under the various operating environment combinations, and selecting an operating environment combination having a counterfactual calculation result that is greater than a threshold value, so as to represent an ODD; and if the lane line detection precision in autonomous driving performance presentation indices is continuously less than a set threshold value, enabling a function degradation policy or reminding a driver to take over. The safety of autonomous vehicles is effectively improved by means of ODD online monitoring.

IPC Classes  ?

• B60W 60/00 - Drive control systems specially adapted for autonomous road vehicles

Abstract

Provided are a 4D printed polyurethane-based hydrogel material, a preparation method therefor and the use thereof. The 4D printed polyurethane-based hydrogel material comprises a combination of a first dynamic cross-linked polyurethane and a second dynamic cross-linked polyurethane, wherein the swelling degree of the first dynamic cross-linked polyurethane is less than the swelling degree of the second dynamic cross-linked polyurethane, and the chain extenders in the first dynamic cross-linked polyurethane and the second dynamic cross-linked polyurethane are each independently a diol constructed on the basis of the Diels-Alder reaction. By means of designing and compounding dynamic cross-linked polyurethane having different swelling degrees, the 4D printed polyurethane-based hydrogel material has a swelling mismatch structure and a water-triggered enhancement property, shows good mechanical properties and biocompatibility, can transform from a one-dimensional shape to a three-dimensional shape by virtue of its own temperature-sensitive and water-responsive properties, and is expected to be used in filling tissue defects by means of minimally invasive surgeries.

IPC Classes  ?

• C08L 75/08 - Polyurethanes from polyethers
• A61L 27/18 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• A61L 27/52 - Hydrogels or hydrocolloids
• C08J 3/075 - Macromolecular gels
• C08G 18/66 - Compounds of groups , , or
• C08G 18/42 - Polycondensates having carboxylic or carbonic ester groups in the main chain
• C08G 18/48 - Polyethers
• C08G 18/32 - Polyhydroxy compoundsPolyaminesHydroxy amines
• C08G 18/12 - Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step using two or more compounds having active hydrogen in the first polymerisation step
• B33Y 70/00 - Materials specially adapted for additive manufacturing

Abstract

The present application relates to a crowd trampling and crushing risk assessment method and apparatus, a device, and a storage medium. The method comprises: rasterizing image data of a crowd activity area, and extracting static attribute information of each raster geographic unit, so as to construct a three-dimensional pedestrian road network; using an image analysis technology to extract dynamic attribute information from image monitoring data of the crowd activity area, and mapping the dynamic attribute information to corresponding raster geographic units, so as to construct a crowd movement interaction network; coupling the three-dimensional pedestrian road network with the crowd movement interaction network, using the static attribute information and the dynamic attribute information to construct a trampling and crushing comprehensive risk index, and obtaining a dynamic risk value of each raster geographic unit, so as to generate a crowd trampling and crushing risk graph. The embodiments of the present application fully consider the static attribute information such as road width and slope of the crowd activity area, thus more precisely assessing crowd trampling and crushing risks and providing early warning.

IPC Classes  ?

• G06Q 10/0635 - Risk analysis of enterprise or organisation activities
• G06V 20/52 - Surveillance or monitoring of activities, e.g. for recognising suspicious objects
• G06Q 10/0639 - Performance analysis of employeesPerformance analysis of enterprise or organisation operations
• G06F 16/29 - Geographical information databases

Abstract

A few-shot point cloud semantic segmentation method and apparatus, a computer device, and a storage medium. The method comprises: acquiring a support set point cloud and a query set point cloud corresponding to a mask, and performing feature extraction on the support set point cloud and the query set point cloud to obtain support set features and query set features; calculating the distance between the support set features and the query set features, and aligning the support set features on the basis of the distance to obtain the aligned support set features; acquiring corresponding prototypes on the basis of masks of the aligned support set features, splicing the prototypes and the query set features to obtain extended query set features, extracting point cloud feature distribution information from the extended query set features, and calibrating the point cloud feature distribution information; and segmenting calibrated point cloud feature distribution information to obtain calibrated prototypes and calibrated query set features. The present application can reduce the reasoning time and greatly reduce point cloud segmentation errors.

IPC Classes  ?

• G06T 7/10 - SegmentationEdge detection

Abstract

Disclosed in the present invention are a diffusion model and generative adversarial network-based image segmentation method and apparatus, which are applied to the technical field of image processing. The method comprises: preprocessing a raw image; training a diffusion model for a preprocessed image and outputting a predicted label image; training a discriminator model for the predicted label image and outputting a predicted classification label image; jointly training the diffusion model and a discriminator by using a generative adversarial network and outputting a parameter of the diffusion model and a parameter of the discriminator model; and segmenting the preprocessed image on the basis of the parameter of the diffusion model and the parameter of the discriminator model, so that the misleading by an individual piece of information in a denoising process is avoided and the robustness of the model is improved. In the training process, by splicing the raw image and label data, extraction of blood vessels is more accurate. The generative adversarial network trains the discriminator and the diffusion model, so that the network training is converged in an accelerated mode and the accuracy of segmentation is improved.

IPC Classes  ?

• G06T 7/11 - Region-based segmentation
• G06T 7/00 - Image analysis

Abstract

A method for rapid construction of an rDNA array and a use of the method in the manual regulation of an rDNA copy number, relating to molecular biology and molecular technology. The present invention provides a method for rapid construction of an rDNA array, capable of constructing a homogenized and synthetic rDNA array on any selected site in a genome-wide range. On this basis, according to the present invention, a recombinase system, for example, a Cre-loxP system, can be further introduced into rDNA units of a synthetic rDNA array to mediate the rearrangement between the rDNA units, thereby achieving the objective of manually regulating an rDNA copy number.

IPC Classes  ?

• C12N 15/81 - Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
• C12N 15/65 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression using markers
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12R 1/865 - Saccharomyces cerevisiae

Abstract

An autonomous driving test platform based on virtual-real integration technology, which platform belongs to the technical field of autonomous car testing. On the basis of cloud-edge-end three-level linkage, the platform combines real environment testing and sand table environment testing with virtual simulation technology. A vehicle-end real scene is an actual environment in which an autonomous vehicle is applied; and environmental information is collected, and feedback is provided for the environmental information and virtual-real fusion information. In a cloud-end virtual environment, in addition to building an autonomous driving virtual scene, data fusion is also performed on information from a real scene and a sand table scene, so as to generate virtual-real fusion data. A sand table environment is used as an edge portion to provide a relay space, which is used for bridging the cloud-end virtual environment to a vehicle-end real environment, digitally twinning the autonomous vehicle in the actual environment to a virtual simulation environment, and transmitting the virtual-real fusion information to the autonomous vehicle. The sand table environment, the virtual environment and the real environment fully interact with one another to implement data enhancement, thereby obtaining an optimal test effect.

IPC Classes  ?

• G01M 17/007 - Wheeled or endless-tracked vehicles

Abstract

Disclosed in the present invention is a cerebral function coupling analysis method based on electrophysiological and blood microcirculation signals. The method comprises: in different motion states, synchronously acquiring an electroencephalogram signal and an fNIRS signal of a subject, and preprocessing same to obtain a preprocessed electroencephalogram signal and a cerebral oxygen signal; performing complete ensemble empirical mode decomposition with adaptive noise on the electroencephalogram signal, so as to obtain a plurality of different sub-band components; symbolizing the plurality of different sub-band components of the electroencephalogram signal and a time sequence of the cerebral oxygen signal, so as to obtain symbolic sequences of the different sub-band components and a symbolic sequence of the cerebral oxygen signal; calculating the transfer entropy between every pair of the symbolic sequences of the different sub-band components and the symbolic sequence of the cerebral oxygen signal; and on the basis of the transfer entropy, analyzing the degree of coupling between the electroencephalogram signal and the cerebral oxygen signal. The present invention explores nonlinear coupling characteristics and information transfer of electrophysiological and blood microcirculation signals, thereby providing a basis for exploring the mechanism of generation of motion dysfunction and for proposing cooperative rehabilitation intervention means.

IPC Classes  ?

• A61B 5/369 - Electroencephalography [EEG]

Abstract

An information interaction system and method based on sensory enhancement. In the system, an image display and feedback module obtains force signal features through interactive touch with a user, then transmits the force signal features and an image feature signal volume to an image content identification and encoding module, and transmits a reference signal volume to a sensory induction module. The image content identification and encoding module is configured to: on the basis of the image feature signals, use a classification model to obtain image content information; on the basis of the force signal features, use a deep learning model to obtain contact pressure information and contact position information of the user touching the image; and then on the basis of the image content information, the contact pressure information and the contact position information, generate sensory encoding information. The sensory induction module is configured to: on the basis of the sensory encoding information, generate an electrical stimulation signal capable of inducing the brain of the user to generate realistic sensations. The invention enhances the efficiency and accuracy of information interaction processes for users by means of sensory enhancement.

IPC Classes  ?

• G06F 3/041 - Digitisers, e.g. for touch screens or touch pads, characterised by the transducing means
• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer

Abstract

A fuel cell fault diagnosis method based on a neural network. The method comprises: for a PEMFC system, acquiring operating state data, wherein the PEMFC system comprises a humidifier and a fuel cell stack; inputting the operating state data into a trained fault pre-diagnosis model, so as to predict a fault diagnosis result of the fuel cell stack at a subsequent moment. The fault pre-diagnosis model is constructed on the basis of a Transformer neural network, and comprises an encoder and a decoder, wherein the encoder comprises a plurality of small encoders, and each small encoder is provided with a self-attention layer and a feedforward neural network layer; and the decoder comprises a plurality of small decoders, and each small decoder comprises a self-attention layer, an attention layer and a feedforward neural network layer. An early warning can be provided for a water management fault of a PEMFC in an operating state, and the accuracy of pre-diagnosis is effectively improved.

IPC Classes  ?

• G06N 3/02 - Neural networks
• H01M 8/04992 - Processes for controlling fuel cells or fuel cell systems characterised by the implementation of mathematical or computational algorithms, e.g. feedback control loops, fuzzy logic, neural networks or artificial intelligence
• H01M 8/04664 - Failure or abnormal function
• G06N 3/08 - Learning methods

Abstract

Disclosed in the present invention are a few-shot point cloud semantic segmentation method based on difference enhancement, and a related device. The method comprises: obtaining various initial prototypes on the basis of support set features and corresponding support set masks; calculating similarities between the initial prototypes and query set features, so as to obtain probability distributions of the query set features belonging to foreground and background categories; inverting foreground distributions on the basis of background-foreground difference enhancement, combining same with current background distributions to obtain accurate background probability distributions, and performing integration to obtain a reliable probability distribution of the categories as a whole; transforming the query set features by means of a feature aggregation module, so as to obtain aggregated query set features; on the basis of the reliable probability distribution and the aggregated query set features, performing aggregation by means of a prototype rectification module, so as to obtain pseudo prototypes; and on the basis of the pseudo prototypes, expanding support set data by means of the prototype rectification module, so as to obtain corrected prototypes, and obtaining a point cloud segmentation result on the basis of the corrected prototypes. The present invention achieves a better segmentation effect.

IPC Classes  ?

• G06V 10/26 - Segmentation of patterns in the image fieldCutting or merging of image elements to establish the pattern region, e.g. clustering-based techniquesDetection of occlusion

Abstract

The present invention relates to a cuffless continuous blood pressure measurement method, comprising: synchronously acquiring BCG signals and PPG signals of a subject; removing noise from the BCG signals and the PPG signals, and assessing beat by beat the signal quality of the BCG signals and the PPG signals; for the BCG signals and the PPG signals that meet signal quality requirements, detecting relevant feature point locations, and extracting PTT features, BCG signal features and PPG signal features from the relevant feature point locations; and on the basis of the extracted PTT features, BCG signal features and PPG signal features and statistical data and calibrated blood pressure of a user, calculating a blood pressure value by using a PTT model and a multi-parameter model. The present invention further relates to a cuffless continuous blood pressure measurement system. The present invention can implement cuffless, low-load and high-precision blood pressure measurement.

IPC Classes  ?

• A61B 5/021 - Measuring pressure in heart or blood vessels
• G06F 18/213 - Feature extraction, e.g. by transforming the feature spaceSummarisationMappings, e.g. subspace methods

Abstract

Disclosed in the present application are a terahertz refractive index-optical rotation common-optical-path joint measurement method and system based on a quantum weak value amplification effect, and an application of the system. The method comprises: performing pre-selection, wherein a polarization state α of an incident terahertz wave emitted by a terahertz time-domain spectral unit is used as a pre-selected quantum state, the polarization state α being selected by means of a first polarizer; performing post-selection, wherein a polarization state α+π2 selected by means of a second polarizer is used as a post-selected quantum state; before measurement, making the post-selected quantum state and the pre-selected quantum state orthogonal to each other; and performing two instances of common-optical-path joint weak coupling, wherein two instances of weak coupling are sequentially performed on the terahertz wave and a sample to be subjected to measurement that is on a common-optical-path joint measurement unit. In the present application, the high-sensitivity characteristic of quantum weak measurement in which a signal is amplified but technical noise is not amplified is used, and by means of common-optical-path joint measurement, the refractive index and optical rotation of a measured chiral drug can be jointly measured with high sensitivity, without the need to change an optical path, thereby realizing high-sensitivity conformation recognition of the chiral drug.

IPC Classes  ?

• G01N 21/3586 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using far infrared lightInvestigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using Terahertz radiation by Terahertz time domain spectroscopy [THz-TDS]

Abstract

An active, low-cost and healthy electrically adjustable display mount, comprising a rotating portion, a lifting/lowering portion, and a support portion. The rotating portion is connected to a display, the lifting/lowering portion is fixed on the support portion, and the lifting/lowering portion drives the rotating portion to vertically move, achieving the vertical movement of the display. The rotating portion drives the display to rotate on a plane where a display screen of the display is located. By means of the electrically adjustable display mount, the height and angle of the display can be electrically adjusted, and switching between landscape display and portrait display can also be achieved by a single press; additionally, by means of a lifting/lowering motor and a rotating motor, upward or downward slow reciprocating motion and clockwise or anticlockwise slow rotating motion are achieved, so that in the long-term working process, a user can unconsciously and passively follow the screen to move the head, achieving the effect of moving the neck and the shoulder.

IPC Classes  ?

• F16M 11/04 - Means for attachment of apparatusMeans allowing adjustment of the apparatus relatively to the stand
• F16M 11/18 - Heads with mechanism for moving the apparatus relatively to the stand
• F16M 11/42 - Stands or trestles as supports for apparatus or articles placed thereon with arrangement for propelling the support
• F16M 11/10 - Means for attachment of apparatusMeans allowing adjustment of the apparatus relatively to the stand allowing pivoting around a horizontal axis

Abstract

A phosphorus-based material hybridized polymer coating, comprising the following components in parts by weight: 80-105 parts of a resin, 2-10 parts of a phosphorus-based material photoinitiator, 1-5 parts of a photoinitiator, and 1-2 parts of a leveling agent. The resin comprises an unsaturated double/triple bond and an acrylate unit. A covalent P-C bond between a phosphorus-based material and a polymer is generated by means of free radical reaction initiated by UV, resulting in firm embedding of the phosphorus-based material into the polymer structure. Migration of the phosphorus-based material is regulated by means of the UV, so as to enrich the phosphorus-based material on the surface of the coating. By means of the good water absorption capability of the phosphorus-based material, the phosphorus-based material can prevent water from permeating into the coating. A long-acting superhydrophilic polymer heterogeneous network coating hybridized with the phosphorus-based material is prepared.

IPC Classes  ?

• C09D 175/14 - Polyurethanes having carbon-to-carbon unsaturated bonds
• C09D 171/02 - Polyalkylene oxides
• C09D 7/61 - Additives non-macromolecular inorganic
• G02B 1/10 - Optical coatings produced by application to, or surface treatment of, optical elements
• G02B 1/18 - Coatings for keeping optical surfaces clean, e.g. hydrophobic or photo-catalytic films

Abstract

A multi-modal contrast agent and a preparation method therefor and a use thereof. The multi-modal contrast agent comprises, in parts by weight: 1 part of a fluorescent precursor, 10-15 parts of a contrast agent, 5-8 parts of dipalmitoylphosphatidylcholine, and 1-3 parts of cholesterol, wherein the fluorescent precursor has a structure as represented by formula 1. The relaxation rate is improved, and the limitations of low sensitivity and high background noise in MRI are broken.

IPC Classes  ?

• A61K 49/00 - Preparations for testing in vivo
• A61K 49/12 - Macromolecular compounds
• A61K 49/10 - Organic compounds
• A61K 49/18 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
• C07D 513/04 - Ortho-condensed systems

Abstract

A handheld combined optical target and a calibration method. The handheld combined optical target comprises a positioning target body, a surface scanning head, a handle and a hinge rotating mechanism, wherein one side of the surface scanning head is connected to a bottom end of the positioning target body by means of the hinge rotating mechanism, and the handle is arranged at the side of the positioning target body. A target surface is scanned by means of the surface scanning head, thereby improving the three-dimensional scanning efficiency; and the positioning target body of the optical target can be easily positioned by means of a visual system, so as to provide a new low-cost space tracking method for large-view-of-field stitch scanning. The switching between two fixing and fastening modes improves the flexibility of measurement.

IPC Classes  ?

• G01B 11/24 - Measuring arrangements characterised by the use of optical techniques for measuring contours or curvatures
• G01B 11/00 - Measuring arrangements characterised by the use of optical techniques

Abstract

Provided are an ovary-targeting polypeptide, a derivative of the polypeptide, and the use of the polypeptide in the preparation of a drug or reagent for treating ovarian related reproductive diseases and preventing and treating the in-vivo or in-vitro aging of oocytes. The diseases comprise menstrual cycle disorder, polycystic ovary syndrome, androgenic phenotype, hair loss, abnormal metabolism, ovarian insufficiency, premature ovarian failure, ovulation failure, abnormal glucose metabolism, and abnormal lipid metabolism, preferably, hyperglycemia and insulin resistance. In addition, the polypeptide is expected to prolong the preservation time and improve the preservation quality of oocytes or fertilized eggs in the field of assisted reproduction.

IPC Classes  ?

• A61K 38/10 - Peptides having 12 to 20 amino acids
• A61P 5/26 - Androgens
• C07K 9/00 - Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequenceDerivatives thereof

Abstract

The present application relates to a multi-view camera calibration method and apparatus, a device, and a storage medium. The method comprises: using a two-dimensional calibration board-based marking method to acquire intrinsic parameter data of each camera, and obtaining a camera intrinsic parameter matrix; using a single point calibration object-based marking method to acquire extrinsic parameter data of each camera, and obtaining a camera extrinsic parameter matrix; and on the basis of the camera intrinsic parameter matrix and the camera extrinsic parameter matrix, displaying a camera calibration result. Embodiments of the present application use a marking method combining a two-dimensional calibration board-based marking method and a single point calibration object-based marking method to respectively mark intrinsic parameters and extrinsic parameters of the cameras, such that the intrinsic parameters and extrinsic parameters of completely opposite cameras in a large scene can be quickly acquired at low cost, thereby enabling calibration of cameras to be more convenient and less labor intensive while improving the precision of camera calibration.

IPC Classes  ?

• G06T 7/80 - Analysis of captured images to determine intrinsic or extrinsic camera parameters, i.e. camera calibration

Abstract

Disclosed in the present invention is a hand exoskeleton for rehabilitation. The hand exoskeleton for rehabilitation comprises a base, a driving mechanism and a phalangeal sleeve, wherein the base is configured to be worn on an extensor side of a metacarpal bone; the driving mechanism is arranged on the base and comprises at least one driving unit; and the phalangeal sleeve is worn on an extensor side of a phalanx, at least one phalangeal sleeve is provided, the phalangeal sleeve is in transmission connection with the driving unit, and the driving unit can drive the phalangeal sleeve to rotate so as to assist in flexion or extension of the phalanx. The hand exoskeleton for rehabilitation can effectively adapt to different rehabilitation requirements of different patients for finger joints, thereby achieving the effects of performing intervention and assisting in terms of rehabilitation in different rehabilitation stages.

IPC Classes  ?

• A61H 1/02 - Stretching or bending apparatus for exercising

Abstract

A characterization and analysis method for the dynamic properties of a cluster, a system, an electronic device, and a computer readable storage medium. The method comprises: acquiring atomic trajectory data; acquiring an average atomic trajectory on the basis of the atomic trajectory data; and obtaining the dynamic lifetime of a cluster on the basis of the average atomic trajectory. By means of an atomic trajectory averaging method, transient detachment and bonding of atoms can be considered at the same time, so that the calculation of the dynamic lifetime of clusters is more accurate.

IPC Classes  ?

• G16C 60/00 - Computational materials science, i.e. ICT specially adapted for investigating the physical or chemical properties of materials or phenomena associated with their design, synthesis, processing, characterisation or utilisation
• G16C 10/00 - Computational theoretical chemistry, i.e. ICT specially adapted for theoretical aspects of quantum chemistry, molecular mechanics, molecular dynamics or the like

Abstract

Disclosed in the present application is a self-locking gripping power-assist apparatus suited to complex terrains, relating to the technical field of exoskeleton robots. The apparatus not only allows medical staff to pick up stretchers on complex terrains, but also provides assistance in picking up and carrying stretchers. The apparatus comprises a winding apparatus, a quick connector, and a self-locking gripper. The winding apparatus comprises an outer housing, a reel, a Bowden cable, a coil spring, and a Bowden cable locking mechanism, wherein an outer housing shaft part is provided within the outer housing, and the reel is sleeved on the outer housing shaft part; the upper end of the Bowden cable is connected to and wound around the reel, and the lower end of the Bowden cable is connected to the quick connector; the coil spring is disposed between the outer housing shaft part and the reel, and provides the reel with a winding force for driving the Bowden cable to retract; the Bowden cable locking mechanism can prevent the Bowden cable from extending or retracting; the self-locking gripper can grip and lock a stretcher handle; and after the self-locking gripper grips the stretcher handle, the quick connector automatically locks the self-locking gripper in a preset position, and quickly connects the self-locking gripper to the outer housing of the winding apparatus.

IPC Classes  ?

• B25J 9/00 - Programme-controlled manipulators
• B25J 19/00 - Accessories fitted to manipulators, e.g. for monitoring, for viewingSafety devices combined with or specially adapted for use in connection with manipulators

Abstract

The present application relates to a PET imaging method and apparatus based on optical flow registration, and a device and a storage medium. The method comprises: correcting the position of an MR image, and extracting a first feature map of the PET image and a second feature map of a corrected MR image; performing feature enhancement processing of a spatial dimension and a channel dimension on both the first feature map and the second feature map, and fusing feature enhancement processing results of the spatial dimension and the channel dimension to generate a first multi-modal enhanced feature map of the PET image and a second multi-modal enhanced feature map of the corrected MR image; and fusing the first multi-modal enhanced feature map and the second multi-modal enhanced feature map by means of a cross-modal feature fusion module and using a multi-head cross-attention mechanism, so as to generate a multi-modal fused feature map, and on the basis of the multi-modal fused feature map, generating a reconstructed PET image. By means of the present application, the features of PET and MR can be effectively fused to obtain a clearer reconstructed PET image.

IPC Classes  ?

• G06T 5/00 - Image enhancement or restoration
• G06T 11/00 - 2D [Two Dimensional] image generation
• G06T 19/00 - Manipulating 3D models or images for computer graphics

Abstract

Disclosed in the present invention are an acoustic impedance matching material, a preparation method therefor, and a use thereof. The acoustic impedance matching material comprises a plurality of impedance layers which are stacked; along the stacking direction, the impedance layers are sequentially arranged according to the exponential change relationship of acoustic impedance; each impedance layer comprises a liquid matrix material and a filler located in the liquid matrix material. The acoustic impedance matching material in the present invention enables ultrasonic to maintain sufficient energy and large bandwidth to enter the skull, achieves high imaging resolution and high focusing intensity, can guarantee efficient transcranial ultrasonic energy transmission, and is thus used for brain disease observation and treatment.

IPC Classes  ?

• A61B 8/08 - Clinical applications
• A61N 7/02 - Localised ultrasound hyperthermia

Abstract

The present invention specifically relates to the technical field of household appliances, and provides a hoisting torsion balance device. The hoisting torsion balance device comprises a rotor unit, a support assembly, and a distance changing unit. The rotor unit comprises a gyroscope, the distance changing unit comprises a main body disc and a spherical hinge mechanism, and the spherical hinge mechanism passes through the main body disc and is fixedly connected to the main body disc; a hinge end of the spherical hinge mechanism faces the bottom and is fixedly connected to a driving end of a driving mechanism, and the other end of the driving mechanism is fixed to an upper support; and stress is generated by means of the rotor unit, and the driving mechanism drives the rotor unit to incline, so that the direction of the stress is changed. The balance of a hoisting device is maintained by changing the direction of the stress, the structure is simpler, and the speed is higher during adjustment.

IPC Classes  ?

• B66C 13/08 - Auxiliary devices for controlling movements of suspended loads, or for preventing cable slack for depositing loads in desired attitudes or positions
• B66C 1/00 - Load-engaging elements or devices attached to lifting, lowering, or hauling gear of cranes, or adapted for connection therewith for transmitting forces to articles or groups of articles

Abstract

A high-throughput automatic disinfection device for experimental animal transport cages, the high-throughput automatic disinfection device comprising a front-end support assembly (1), a rear-end support assembly (2) and a disinfection mechanism (3), wherein the disinfection mechanism (3) comprises a bottom frame (4), an upper frame (5) and a disinfection chamber assembly; a plurality of rollers (6) arranged in parallel are provided between a left rim and a right rim of the upper frame (5), and there is a gap between two adjacent rollers (6); the disinfection chamber assembly comprises a chamber body (7), which is a box with a front opening and a rear opening, and ultraviolet lamps (8) are provided on four faces in the box, respectively; and two baffles (9) are provided on a bottom plate of the box, light-blocking curtains (10) are provided at the front open end and the rear open end of the box, respectively, the four faces in the box are reflective faces, and upper light-blocking plates (11) and lower light-blocking plates (12) are provided in the box close to the front opening and the rear opening, respectively. The high-throughput automatic disinfection device for experimental animal transport cages can eliminate pathogenic microorganisms on the outer surface of a transport box outside an animal facility building, thereby reducing the risk of facility contamination, and eliminating the health risks of the staff in the facility building.

IPC Classes  ?

• A61L 2/10 - Ultraviolet radiation
• A61L 2/24 - Apparatus using programmed or automatic operation
• A61L 2/26 - Accessories

Abstract

Provided in the present application are a viscosity-adjustable hydrogel material, and a preparation method therefor and the use thereof. The preparation raw materials of the viscosity-adjustable hydrogel material comprise the following components in parts by weight: 10-30 parts of a monomer, 1-20 parts of a cross-linking agent, 0.1-5 parts of a long-chain polymer, 0.01-5 parts of dopamine hydrochloride, 0.01-5 parts of clay and 50-90 parts of water. By means of selection of chemical components and regulation of the amounts thereof, the viscosity-adjustable hydrogel material provided in the present application can easily realize the compatibility and regulation of surface adhesive and non-adhesive properties of the hydrogel material, and also has an anti-freezing moisture retention property, a self-healing property, biocompatibility, flexibility and elasticity, such that same can be applied to biomedical materials or flexible electronic devices.

IPC Classes  ?

• C08L 33/26 - Homopolymers or copolymers of acrylamide or methacrylamide
• C08J 3/075 - Macromolecular gels
• C08F 220/56 - AcrylamideMethacrylamide
• C08F 222/20 - Esters containing oxygen in addition to the carboxy oxygen
• C08L 71/02 - Polyalkylene oxides
• C08K 3/34 - Silicon-containing compounds
• A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
• A61K 47/38 - CelluloseDerivatives thereof
• H01B 1/00 - Conductors or conductive bodies characterised by the conductive materialsSelection of materials as conductors
• H01B 1/12 - Conductors or conductive bodies characterised by the conductive materialsSelection of materials as conductors mainly consisting of other non-metallic substances organic substances

Abstract

Disclosed in the present invention is an artificial hand finger capable of reproducing the functions of an approach phase and a grasp phase of hands. The artificial hand finger comprises a metacarpal bone, a proximal knuckle, a middle knuckle, a distal knuckle, a friction clutch, a driving rope, a driven rope, and elastic assemblies. The friction clutch is slidably mounted on the metacarpal bone, the driving rope bypasses the friction clutch, the driving rope is connected to the proximal knuckle at one end thereof and is connected to the middle knuckle at the other end thereof, two ends of the driven rope are respectively connected to the proximal knuckle and the distal knuckle, and the elastic assemblies are arranged between the metacarpal bone and the proximal knuckle, between the proximal knuckle and the middle knuckle and between the middle knuckle and the distal knuckle. In the artificial hand finger, the functions of the approach phase and the grasp phase are combined by means of the friction clutch mounted in the metacarpal bone, such that the bionic performance of the finger during an entire motion process from approaching an object to stably grasping the object is achieved, and the operation experience of a patient with a hand amputated is improved.

IPC Classes  ?

• B25J 15/00 - Gripping heads

Abstract

A terahertz-spectrum quantum weak measurement method and system, and application. The terahertz-spectrum quantum weak measurement method is applied to a terahertz-spectrum quantum weak measurement system (100). The measurement system (100) comprises a first polarizer (104), a second polarizer (105), a terahertz time-domain spectrum unit (101), a transmission end (102), a detection end (103) and a sample carrier (106). The terahertz quantum weak measurement method and system based on the quantum weak-value amplification effect can break through the trace detection limits of the current terahertz technology. A terahertz polarization state (a pre-selected state) is selected, a measured tiny change generates a "micro" disturbance for the terahertz polarization state, and strong measurement is then used to project a disturbed system state to a post-selected state, thereby establishing the terahertz quantum weak-measurement system. Since most chiral drugs have resonance absorbability in a terahertz waveband, high-sensitivity conformation recognition of chiral drugs by using a micro-variation in the optical rotation of chiral molecules as a weak coupling effect is facilitated.

IPC Classes  ?

• G01N 21/3586 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using far infrared lightInvestigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using Terahertz radiation by Terahertz time domain spectroscopy [THz-TDS]
• G06F 17/10 - Complex mathematical operations
• G01N 21/21 - Polarisation-affecting properties
• G01N 21/01 - Arrangements or apparatus for facilitating the optical investigation
• G01N 21/41 - RefractivityPhase-affecting properties, e.g. optical path length

Abstract

Provided is a method for inserting a function peptide fragment into a surface-exposed site of a capsid protein of adeno-associated virus 13 (AAV13), and performing modification to obtain two recombinant AAVs (rAAVs), i.e., rAAV13-585-7m8 and rAAV13-587-7m8, specifically comprising: 1) constructing rAAV packaging plasmids pAAVRC2/13-585-7m8 and pAAVRC2/13-587-7m8 which respectively have the sequences as shown in SEQ ID NO: 5 and SEQ ID NO: 6 and contain a Rep gene of a wild AAV2 and a Cap gene of the AAV13 obtained after modification; and 2) performing co-transfection of two serotype packaging plasmids pAAVRC2/13-585-7m8 and pAAVRC2/13-587-7m8 together with an AAV expression core plasmid and an adenovirus helper plasmid into HEK-293T cells to obtain rAAV13 mutants rAAV2/13-585-7m8 and rAAV2/13-587-7m8. The preparation method for an AAV can be used for preparing high-titer rAAV13 mutants rAAV13-585-7m8 and rAAV2/13-587-7m8, providing new vector tools for efficient and accurate gene delivery to the brain. The present invention has great significance and potential application value for basic research in neuroscience and gene therapy.

IPC Classes  ?

• C12N 15/864 - Parvoviral vectors
• C12N 7/01 - Viruses, e.g. bacteriophages, modified by introduction of foreign genetic material
• C12N 7/02 - Recovery or purification

Abstract

An interface structure characterization method, comprising: constructing a solid-liquid equilibrium system; acquiring interfacial atomic number density distribution of the solid-liquid equilibrium system; and acquiring interface layers on the basis of the interfacial atomic number density distribution. Compared with previous qualitative characterization methods, characterization parameters of interface structure changes are developed on the basis of computation results of radial distribution functions in interface layers, and the parameters can quantitatively characterize the change characteristics of the interface structure, avoiding the situation where the interface structure can only be qualitatively characterized; the present application can be used for quantitatively characterizing interface structures, can characterize differences in interface structures caused by lattice periodic fields when crystals of different orientations come into contact with melts, structural adjustments needed from melts to crystal melts, and change processes from melts to crystal structures (sudden or gradual changes).

IPC Classes  ?

• G01N 13/00 - Investigating surface or boundary effects, e.g. wetting powerInvestigating diffusion effectsAnalysing materials by determining surface, boundary, or diffusion effects
• G06F 30/20 - Design optimisation, verification or simulation
• G06F 17/10 - Complex mathematical operations
• G06F 119/08 - Thermal analysis or thermal optimisation

Abstract

The present invention provides a use of a VIRMA protein in preparation of a drug for regulating and controlling the early development of a nervous system, and early neural system-specific VIRMA knocked-out cells and animal models are also constructed. In the present invention, an important function of VIRMA in an m6A methyltransferase complex in the nervous system is disclosed.

IPC Classes  ?

• A61K 38/45 - Transferases (2)
• A01K 67/027 - New or modified breeds of vertebrates
• A61K 49/00 - Preparations for testing in vivo
• A61P 25/00 - Drugs for disorders of the nervous system

Abstract

A wastewater treatment apparatus, comprising a plasma generation source (1), an oxygen active particle generation assembly, a hydrodynamic cavitation reaction assembly and a power supply assembly, which are connected in sequence, wherein the plasma generation source (1) is connected to the power supply assembly, and the oxygen active particle generation assembly is connected to the power supply assembly; the oxygen active particle generation assembly comprises an oxygen active particle generator (2), and an air inlet (3) and an oxygen active particle outlet (4) are provided in the oxygen active particle generator (2); and the hydrodynamic cavitation reaction assembly comprises a water inlet (5), a booster pump (6), a hydrodynamic cavitation reactor (7), a flash reactor (8) and a water outlet (9), which are in communication in sequence, the water inlet (5) being in communication with the booster pump (6) by means of a first pipeline (10), and the booster pump (6), the hydrodynamic cavitation reactor (7), the flash reactor (8) and the water outlet (9) being in communication by means of a second pipeline on which several sensors (11) are provided, and the hydrodynamic cavitation reactor (7) is in communication with the oxygen active particle outlet (4). The wastewater treatment apparatus can efficiently kill harmful microorganisms and degrade organic contaminants.

IPC Classes  ?

• C02F 1/72 - Treatment of water, waste water, or sewage by oxidation

Abstract

A multichannel endorectal coil for prostate MRI, a system, and a working method. The coil comprises a support body provided with a winding curved surface, a plurality of first endorectal coils (1, 2, 3) wrapped around the surface of the support body, and a second endorectal coil stacked on the plurality of first endorectal coils (1, 2, 3); wherein two adjacent first endorectal coils (1, 2, 3) are decoupled by means of partial overlapping, and two non-adjacent first endorectal coils (1, 2, 3) are decoupled by providing a shared capacitor (5); the second endorectal coil comprises a first coil section and a second coil section which are in intersecting connection with one another, the first coil section and the second coil section are arranged symmetrically, and no electrical connection exists at the intersection thereof. The invention increases the number of channels, and further achieves better high-resolution imaging capabilities.

IPC Classes  ?

• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G01R 33/34 - Constructional details, e.g. resonators
• G01R 33/36 - Electrical details, e.g. matching or coupling of the coil to the receiver

Abstract

Disclosed in the present invention is a device for efficiently removing dirty bedding from a laboratory animal cage, the device comprising a box, a support frame, a connecting rod and a foot control switch, wherein a base is arranged on the box, the support frame is vertically arranged on the base, one end of the connecting rod is hinged to the support frame, an electric motor is mounted at the other end of the connecting rod, an output shaft of the electric motor is connected to a cleaning head, four rolling wheels are arranged at the bottom of the box, an angle between the connecting rod and the support frame is adjustable, and the height of the connecting rod on the support frame is adjustable; and the foot control switch is connected to the electric motor by means of an electric wire, and the foot control switch is configured to control the starting and stopping of the electric motor. The present invention enables workers of different heights to efficiently treat dirty bedding adhered to the bottom of a cage, avoids damage to the cage caused by removal using a shovel, reduces the risk of cross contamination between facilities or animals, and maintains efficient and safe operation of animal facilities, such that scientific research can be carried out smoothly.

IPC Classes  ?

• B08B 1/30 - Cleaning by methods involving the use of tools by movement of cleaning members over a surface
• B08B 9/087 - Cleaning of containers, e.g. tanks by methods involving the use of tools, e.g. brushes, scrapers

Abstract

A preparation method for a bionic multi-channel nerve conduit, and a bionic multi-channel nerve conduit. A double-layer shape memory nanofiber membrane is used as a receiving substrate, strip-shaped and spaced gel strips are printed on an oriented side, seed cells are planted on the strip-spaced nanofiber membrane, temperature changes are adjusted to cause the fiber membrane at the bottom layer to have a deforming response and curl up, gel strips wrapped by the self-curling fiber membrane self-shape into a conduit, gaps between the gel strips form a multi-channel structure inside the conduit, an inner wall of the multi-channel nerve conduit becomes oriented natural polymer nanofibers which can provide directional guidance for nerve regeneration, and the multi-channel tube structure promotes the formation of a vascular network in the conduit and provides more space for nerve cell growth. The present invention can be applied to long-distance peripheral thick nerve defects, and has good application prospects.

IPC Classes  ?

• A61L 27/18 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• D01D 5/00 - Formation of filaments, threads, or the like
• A61L 27/38 - Animal cells
• A61L 27/50 - Materials characterised by their function or physical properties
• A61L 27/54 - Biologically active materials, e.g. therapeutic substances

Abstract

Disclosed in the present application are an analogical prompting-based incremental learning method, apparatus and device, and a storage medium. The method comprises the steps: acquiring a data set to be classified, said data set comprising training set data and test set data; on the basis of current task data and historical task data among the training set data, calculating analogical parameters of categories in corresponding historical task data, and combining the analogical parameters with the current task data, so as to obtain analogical sample data; on the basis of the current task data, finely adjusting a preset classification model, so as to obtain a finely-adjusted preset classification model, and, on the basis of the analogical sample data, eliminating bias generated by a clustering center of the historical task data, so as to obtain unbiased clustering center data; and, on the basis of the finely-adjusted preset classification model and the clustering center data, classifying the test set data, so as to obtain classified data. The present application reduces the storage cost of models.

IPC Classes  ?

• G06F 18/22 - Matching criteria, e.g. proximity measures

Abstract

The use of a polylactic acid-glycolic acid copolymer scaffold in the promotion of chondrogenic differentiation and regeneration other than the diagnosis and treatment of diseases, wherein the polylactic acid-glycolic acid copolymer is PLGA (50:50). The polylactic acid-glycolic acid copolymer scaffold can promote the differentiation of chondrocyte precursors into cartilage and increase the formation of cartilage collagen matrix and chondroproteoglycan. A degradation and release liquid of the polylactic acid-glycolic acid copolymer scaffold can effectively promote the differentiation of chondrocyte precursors into cartilage and increase the formation of cartilage collagen matrix and chondroproteoglycan, thereby playing a role in promoting cartilage regeneration.

IPC Classes  ?

• A61L 27/18 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• A61L 27/58 - Materials at least partially resorbable by the body
• A61L 27/54 - Biologically active materials, e.g. therapeutic substances
• A61L 27/56 - Porous or cellular materials

Abstract

A temperature measuring method and apparatus based on creatine chemical exchange saturation transfer (CEST) imaging. The method comprises the following steps: (1) performing creatine CEST imaging on a creatine phantom, and analyzing a chemical shift of creatine relative to water in the creatine phantom; (2) fitting a mathematical relation between the chemical shift of the creatine relative to water and the temperature; and (3) performing CEST imaging on creatine in a sample, and calculating the temperature according to the mathematical relation, fitted in step (2), between the chemical shift of the creatine relative to water and the temperature. In the temperature measuring method, the creatine is taken as an endogenous reference, and highly-spatial-resolution, highly-sensitive, and non-invasive absolute temperature measurement can be implemented by means of temperature dependence of a CEST effect of Cr and water.

IPC Classes  ?

• A61B 5/01 - Measuring temperature of body parts
• G01K 11/00 - Measuring temperature based on physical or chemical changes not covered by group , , , or

Abstract

The invention relates to a directional coupler, coupling high power and low power is used to replace existing two high-power directional couplers, thus reducing the cost and reducing the insertion loss of high-power radio frequency channels. The directional coupler cooperates with a control conditioning board, a splitter, a multi-path radio frequency power amplifier and a combiner to form the radio frequency power amplifier system, and the system is connected to a spectrometer; on one hand, by using a standard signal output by the spectrometer and a feedback signal of the directional coupler, nonlinearity caused by the power amplifier is corrected to achieve magnet-free linear radio frequency power amplification and anomaly protection; and on the other hand, the spectrometer can be used for monitoring the output power of the directional coupler and monitoring antenna matching, so as to provide dual protection for the radio frequency power amplifier system.

IPC Classes  ?

• H01P 5/18 - Conjugate devices, i.e. devices having at least one port decoupled from one other port consisting of two coupled guides, e.g. directional couplers
• G01R 23/16 - Spectrum analysisFourier analysis

Abstract

The present invention relates to the technical field of special robots. Disclosed are an amphibious robot, a control method and a use. The amphibious robot comprises a body, a movement mechanism, and a control unit; the movement mechanism comprises a plurality of wheel paddle mechanisms and a plurality of wheel paddle drivers; each wheel paddle mechanism comprises a rotating wheel and a web. The present invention achieves the movement of the robot in two environments; the wheel paddle mechanism designed in some embodiments can achieve an obstacle surmounting function of the robot; according to the present invention, the wheel paddle mechanism uses the wheel-paddle coupling design, so that the robot achieves omnidirectional movement in three-dimensional directions in water and on the land under the driving of four motors; an upper air bag and a lower air bag of the robot can achieve fixed depth control under any gait of the robot; the wheel paddle mechanism in the present invention is designed on the basis of a bionic principle, the design is inspired from fish swimming, the web is similar to a caudal fin, the movement of the web simulates the caudal fin of a fish, and the wheel paddle mechanism has a movement posture similar to that of fishes in water and has an excellent underwater movement capability.

IPC Classes  ?

• B60F 3/00 - Amphibious vehicles, i.e. vehicles capable of travelling both on land and on waterLand vehicles capable of travelling under water

Abstract

222222@MTX@ZIF67. For two main pathological features, i.e., inflammation and an anoxic microenvironment, of rheumatoid arthritis, calcium peroxide loaded by ZIF67 is combined with methotrexate to jointly treat the inflammatory part of rheumatoid arthritis, so that a construct can inhibit expression of a tumor necrosis factor -α/interleukin-6 and overcome the anoxic property of rheumatoid arthritis, thereby achieving the technical characteristics of mitigating an inflammatory symptom, changing a disease process, being low in cost, less in side effect and used for long-term treatment, and the like.

IPC Classes  ?

• A61K 9/14 - Particulate form, e.g. powders
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61K 33/40 - Peroxides
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
• A61P 37/02 - Immunomodulators

Abstract

The preparation method of a gas phase diffusion electrode for electrocatalyzing CO2 to reduce and produce CO provided by the present application comprises: mixing a conductive polymer monomer solution with a molar ratio of 100:1˜1:100 with a metal salt solution, and adding a dispersant to form a mixed solution; transferring the mixed solution to a substrate and reacting at a temperature of −30° C.-50° C. for 1-48 hours to obtain a gas phase diffusion electrode. By the method of using metal ions to self-initiate in-situ growth of conductive polymer monomers, the present application forms a metal-conductive polymer gas phase diffusion electrode. Due to the characteristics of the conductive polymer, the gas phase diffusion electrode can provide more nucleation sites, achieving similar catalytic effect while reducing use amount of metal.

IPC Classes  ?

• C25B 11/032 - Gas diffusion electrodes
• C25B 1/23 - Carbon monoxide or syngas

Abstract

Use of phosphorus-based material in preparation of medicament for treating tumors. The phosphorus-based material is selected from a material which is convertible to produce phosphate ions in an acidic environment, and the phosphorus-based material can be converted by tumor cells phagocytosis to produce a large number of phosphate ions to change the intraceullar environment and extracellular environment, thereby inhibiting proliferation of tumor cells and inducing death of tumor cells. This process has no significant effect on normal cell activities. By applying the phosphorus-based material to the preparation of a medicament for treating tumor in a manner as mentioned above, the amplification and metastasis of tumor cells can be effectively inhibited, thereby the metastasis of the tumor cells and recurrence of the tumor can be prevented more effectively, improving the therapeutic effect of the tumor. The phosphorus-based material has little effect on normal cells and tissues in the course of treatment.

IPC Classes  ?

• A61K 33/42 - PhosphorusCompounds thereof
• A61P 35/00 - Antineoplastic agents

Abstract

An adult mouse tail tissue sampling device, comprising a base (1), wherein a fixed assembly is fixedly mounted on the base (1), and the fixed assembly is a cover plate (2) having a conical surface structure; a cavity is formed between the cover plate (2) and the base (1); the cover plate (2) has an open end with a large cross section; a slit (3) is provided in the cover plate (2), and the slit (3) extends from the open end toward the other end of the cover plate (2); and an object placement platform (4) is provided on the side of the base (1) away from the open end of the cover plate (2), a fixing plate (5) is provided on the object placement platform (4), and a plurality of holes are provided in the fixing plate (5). The provided adult mouse tail tissue sampling device can physically isolate mice, prevent sampling staff members from being bitten, and also improve the sampling efficiency.

IPC Classes  ?

• A61B 10/02 - Instruments for taking cell samples or for biopsy

Abstract

The present application provides a preparation method of a gas phase diffusion electrode for electrocatalyzing CO2 to reduce and produce formic acid and an application thereof, comprising: obtaining first mixed solution, obtaining second mixed solution, uniformly mixing the first mixed solution and the second mixed solution, coating them onto a surface of a substrate, and then placing them at a temperature of −30° C.-100° C. for 1-48 hours to obtain the gas phase diffusion electrode. In the preparation method, conductive polymer monomer and bismuth or tin based metal component are coated onto the surface of the substrate to form an integrated conductive polymer-catalyst/hydrophobic substrate composite gas phase diffusion electrode, not only can the stability between metal active components and the substrate material be enhanced, but also characteristics such as better conductivity, higher specific surface area, abundant surface chemical reaction sites, and so on are provided.

IPC Classes  ?

• C25B 11/032 - Gas diffusion electrodes
• C25B 3/07 - Oxygen containing compounds
• C25B 3/26 - Reduction of carbon dioxide
• C25B 11/052 - Electrodes comprising one or more electrocatalytic coatings on a substrate
• C25B 11/075 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of a single catalytic element or catalytic compound

Abstract

A CT imaging method and apparatus, and a device and a storage medium. The CT imaging method comprises: by means of a first-layer detector and a second-layer detector of a double-layer detector, respectively collecting first projection data and second projection data that correspond to a target object (S110); determining multiple types of sub-pixels on the basis of the first projection data and pixels of the first-layer detector (S120); determining a target signal strength of each type of sub-pixel on the basis of the first projection data and the second projection data, and on the basis of the target signal strength, obtaining a target projection signal corresponding to the double-layer detector (S130); and on the basis of a super-resolution network model, performing super-resolution processing on the target projection signal to obtain a super-resolution imaging signal, and obtaining a super-resolution imaging image on the basis of the super-resolution imaging signal (S140).

IPC Classes  ?

• G01N 23/046 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by transmitting the radiation through the material and forming images of the material using tomography, e.g. computed tomography [CT]

Abstract

Disclosed in the present invention are a gravity compensation algorithm for a tail end tool of a robotic arm, and a system, a device and a storage medium, which are applied to the field of system software. The method comprises: acquiring the gravity of a tail end tool of a robot; acquiring zero-point values of a force sensor according to the gravity; determining whether a sampling time reaches a preset time T; if the sampling time reaches the time T, calculating zero-point values within the time T, and taking the average value of the zero-point values as a zero-point value at the start of the force sensor; and if the sampling time does not reach the time T, re-acquiring zero-point values of the force sensor; subtracting the gravity and the zero-point value at the start of the force sensor from a reading of the force sensor, so as to obtain a real external force value; and a robotic arm moving to execute a corresponding task. In the method, the average value of zero-point values within a time period after the start of a force sensor is used as a zero-point value at the current start, and a zero-point value is calculated once after each start and is used as the zero-point value at the current start. Therefore, compared to the prior art in which only one fixed zero-point value is taken, the method is more accurate.

IPC Classes  ?

• B25J 9/16 - Programme controls

Abstract

The use of yohimbine drug in the treatment of type 2 diabetes. The yohimbine drug achieves the effect of treating type 2 diabetes by reducing the fasting blood glucose, reducing the glucose tolerance and reducing the insulin resistance in patients with diabetes.

IPC Classes  ?

• A61K 31/475 - QuinolinesIsoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
• A61K 9/00 - Medicinal preparations characterised by special physical form

Abstract

The present application relates to the technical field of medical instruments, and particularly relates to a reusable Laplace valve and a glaucoma drainage device. An existing Laplace valve cannot be reused, and an existing glaucoma drainage device has unstable opening pressure and closing pressure to cause an excessive standard difference. Provided in the present application is a reusable Laplace valve, comprising a liquid channel, wherein an air cavity is provided in the liquid channel; the liquid channel sequentially comprises an inlet, a reusable channel and an outlet; the reusable channel comprises a nozzle and a receiving channel; the inlet is connected to the nozzle; the nozzle and one end of the air cavity are sequentially in communication with one end of the receiving channel, and an air-liquid interface can be formed between the nozzle and the receiving channel, such that droplets can be generated by the nozzle and received downstream, which process is repeated; and the other end of the receiving channel and the other end of the air cavity are sequentially in communication with the outlet. The problem of the existing Laplace valve being unable to be reused is solved.

IPC Classes  ?

• A61F 9/007 - Methods or devices for eye surgery

Abstract

A planar-array ultrasonic transducer, an ultrasound imaging method, and an electronic device. The planar-array ultrasonic transducer comprises a plurality of array elements, wherein the distances between adjacent array elements are consistent; the plurality of array elements are divided into a plurality of sub-array regions, and each sub-array region has M rows and N columns of array elements; the array elements at the same row and column position in the sub-array regions can be connected to the same channel line, and the array elements at different row and column positions in the sub-array regions are connected to different channel lines; the channel line is used for inputting an excitation signal of the planar-array ultrasonic transducer and/or transmitting an ultrasonic echo signal; and at the same moment, for any row and column position, at most only one array element at the row and column position in a sub-array region is connected to the channel line. The ultrasonic transducer reduces the number of channels of the ultrasonic transducer, and can realize sub-aperture transmission or reception at any position on an ultrasonic transducer planar array, thereby improving the flexibility of imaging.

IPC Classes  ?

• A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves

Abstract

The present invention relates to the field of human body motion posture recognition, and in particular to a bipedal gait recognition system and method based on multi-sensor fusion. According to the system, a corresponding gait deep learning LSTM neural network model is obtained by training, and the deep learning LSTM neural network model is stored in a computer. Motion information or data of a human body collected by using the bipedal gait recognition system of the present application is transmitted into the trained deep learning LSTM neural network model, and the current motion state of a user is recognized. The system of the present application collects human body motion information by means of direct contact with a human body, so that the system can conveniently and accurately collect motion information, is easy to carry, is suitable for most motion scenarios and has wide development prospects.

IPC Classes  ?

• G06F 18/21 - Design or setup of recognition systems or techniquesExtraction of features in feature spaceBlind source separation

Abstract

A method and kit for detecting an IL-6 protein on the basis of ALP-mediated ELISA. IL-6 is detected by ALP-catalyzed hydrolysis of APP; on the basis of alkaline phosphatase (ALP)-mediated hydrolysis of APP, the APP has high fluorescence quenching efficiency in the hydrolysis process. Changes in the fluorescence intensity of APP have a good linear relationship with the logarithm of the IL-6 protein concentration within the range of 0.005 ng/mL-5.0 ng/mL, and the detection limit is 0.001 ng/mL, which is 100 times the sensitivity of traditional pNPP-based ELISA. Furthermore, when the colorimetric signal of AP is used for detecting IL-6 by means of colorimetric ELISA, the detection limit is 0.1 ng/mL. The method can be used for visual detection of IL-6, with high sensitivity.

IPC Classes  ?

• G01N 21/76 - ChemiluminescenceBioluminescence
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The present application relates to the technical field of bioinformatics. Provided are a graph neural network construction method and apparatus, and an electronic device and a storage medium. The method comprises: coding single-cell data in a single-cell data set into a low-dimensional latent space, so as to obtain a first feature vector in which a key feature and/or type-specific information of the single-cell data are/is kept; acquiring a constructed gene regulation network, and coding the gene regulation network to obtain a low-dimensional gene node; extracting a local topological feature from the low-dimensional gene node while keeping the global network structure of the gene regulation network, so as to obtain a second feature vector, wherein the second feature vector is used for reflecting interactions among all genes in the single-cell data set; and constructing a graph neural network on the basis of the first feature vector and the second feature vector, wherein the graph neural network is used for automatically performing labeling on the single-cell data. The present application solves the problem in the relevant art of cell labeling being inaccurate, time-consuming and labor-intensive, and being limited by a batch effect.

IPC Classes  ?

• G16B 50/10 - OntologiesAnnotations
• G16B 40/00 - ICT specially adapted for biostatisticsICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
• G06F 18/25 - Fusion techniques
• G06N 3/08 - Learning methods

Abstract

A correction parameter determination method and apparatus, an image reconstruction method and apparatus, and a device and a medium. The correction parameter determination method comprises: acquiring a first relational expression between real signals corresponding to two different energy values and a second relational expression between scattering signals corresponding to the two different energy values (S110); according to the first relational expression, scanning data of a correction phantom that is obtained by means of narrow scanning and corresponds to the two different energy values, and scanning data of an air background that is obtained by means of narrow scanning and corresponds to the two different energy values, determining a first scattering correction parameter set (S120); according to the second relational expression, scanning data of the correction phantom that corresponds to different scanning modes and corresponds to the two different energy values, and scanning data of the air background that is obtained in the different scanning modes and corresponds to the two different energy values, determining a second scattering correction parameter set (S130); and using a combined set of the first scattering correction parameter set and the second scattering correction parameter set as a target scattering correction parameter set (S140).

IPC Classes  ?

• G06T 11/00 - 2D [Two Dimensional] image generation

Abstract

The present invention relates to the technical field of pipe cleaning, and provides a dust removal apparatus for the outer surface of a room pipe of an automatic drinking water system, comprising a long rod, a handle, and cleaning heads. The handle is fixedly mounted at the bottom of the long rod; there are two cleaning heads, which are arranged opposite to each other at the top of the long rod; a mounting shaft is movably mounted at the top of the long rod, the two cleaning heads are both movably sleeved on the mounting shaft, and the cleaning heads are movably mounted at the top of the long rod by means of the mounting shaft; a cleaning groove is formed inside each of the two cleaning heads; a cleaning sponge is arranged on the rear side of the interior of each of the two cleaning grooves; two push rods are embedded into and movably mounted on the wall surface of the rear side of each of the two cleaning heads by means of springs, and mounting slots are formed in each cleaning sponge at the positions corresponding to the push rods; and the depth of the mounting slots is consistent with the length of the push rods exposed outside. The effects of cleaning pipes and collecting dust and impurities are achieved, and after performing cleaning, the cleaning sponges are easy to remove and clean for reuse, thereby solving the problem of difficulty in efficiently cleaning pipes at higher positions.

IPC Classes  ?

• B08B 9/023 - Cleaning the external surfaces

Abstract

A rat MCAO modeling animal fixing apparatus, comprising a bottom plate, and a head fixing member, a front claw fixing member, and rear claw fixing members arranged on a top surface of the bottom plate. The front claws are fixed by using the front claw fixing member, and two middle screws each having a front claw hook-and-loop fastener are arranged on a transverse rail. According to the straightened distance of the front claws, the middle screws are tightened to be fixed on the transverse rail, and then fixing of the upper part of the animal is complete. Rear claw hook-and-loop fasteners on each rear claw fixing member may be fixed at any position on a circular surface having a radius of 5 cm centered on a bottom screw. When the head is fixed, one end of an elastic rubber band is hung on a top fixing rod to control the tightness of the elastic rubber band, and the height may be adjusted according to the thickness of the animal head. The other end of the elastic rubber band is pulled straight and hung on the incisors of the upper jaw of the rat to fix the head. The apparatus solves the problem in traditional methods of an animal not being firmly fixed, which affects the experimental effect and efficiency, and facilitates pulling out the tongue of the animal to prevent the animal from suffocating during the experiment.

IPC Classes  ?

• A61D 3/00 - Appliances for supporting or fettering animals for operative purposes

Abstract

An image reconstruction method and apparatus, an electronic device, and a storage medium. The method comprises: acquiring ray intensity information of a ray after passing through a heterogeneous grid apparatus, the ray intensity information at least comprising a first ray intensity and a second ray intensity (S110); on the basis of the first ray intensity and the second ray intensity, determining an initial scattering projection result (S120); executing filtering correction on the initial scattering projection result to obtain a target scattering projection result (S130); determining a scattering-corrected projection result corresponding to the target scattering projection result, and on the basis of the scattering-corrected projection result corresponding to the target scattering projection result, performing computed tomography image reconstruction to obtain a computed tomography reconstructed image (S140).

IPC Classes  ?

• A61B 6/06 - Diaphragms
• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment

Abstract

An automatic watering system room pipeline outer surface disinfection device, relating to the technical field of life science. The efficiency of disinfection working can be improved, and the safety of operators during disinfection can be improved. The disinfection device comprises a disinfectant storage part (1) and a disinfection rod part (2). The disinfection rod part (2) comprises a wiping assembly (22) and a disinfectant conveying assembly (23); the wiping assembly (22) comprises two semicircular grippers (221); the bottoms of the grippers (221) are fixedly connected to a push rod (226), a groove (224) is formed in each gripper (221), and the groove (224) is filled with a wiping cloth (225); the disinfectant conveying assembly (23) comprises a disinfectant conveying rigid pipe (231) and two disinfectant conveying hoses (232); the disinfectant conveying hoses (232) are located in the grooves (224); a first end of the disinfectant conveying rigid pipe (231) is connected onto a connecting hose (3), and a second end of the disinfectant conveying rigid pipe (231) is connected to first ends of the two disinfectant conveying hoses (232); second ends of the disinfectant conveying hoses (232) are sealed, and the side wall of each disinfectant conveying hose (232) is provided with disinfectant permeation holes (233); a hand-holding sleeve (24) is sleeved on the push rod (226) and the disinfectant conveying rigid pipe (231); the hand-holding sleeve (24) is fixedly connected to the disinfectant conveying rigid pipe (231).

IPC Classes  ?

• A61L 2/18 - Liquid substances
• B08B 9/023 - Cleaning the external surfaces
• A47L 25/00 - Domestic cleaning devices not provided for in other groups of this subclass
• A47L 13/50 - Auxiliary implements
• C09D 5/14 - Paints containing biocides, e.g. fungicides, insecticides or pesticides

Abstract

A dust removal device for an air supply and exhaust pipe main pipeline of an IVC rack, comprising a handle assembly (1), a telescopic rod assembly (2), and a cleaning end assembly (3). The handle assembly (1) and the cleaning end assembly (3) are respectively arranged at two ends of the telescopic rod assembly (2); the telescopic rod assembly (2) comprises at least two rod members, and every two adjacent rod members are positioned by means of a fixing assembly; the cleaning end assembly (3) comprises a first fastening section (31) and a second fastening section (32), and the first fastening section (31) and the second fastening section (32) are both cylindrical structures, and are fixedly connected and are concentrically arranged; one end of the first fastening section (31) is connected to the telescopic rod assembly (2), the second fastening section (32) is sleeved with cleaning cloth, and the outer edge of the cleaning cloth is fixed on the first fastening section (31) by means of a hoop. The dust removal device for an air supply and exhaust pipe main pipeline of an IVC rack can efficiently treat long-term accumulated dust of an air supply and exhaust pipeline, to ensure that the subsequent disinfection effect reaches the standard, thereby ensuring that the microbial control level of experimental animals meets the requirement, maintaining safe operation of animal facilities, and guaranteeing smooth development of scientific research.

IPC Classes  ?

• B08B 9/043 - Cleaning the internal surfacesRemoval of blockages using cleaning devices introduced into and moved along the pipes moved by externally powered mechanical linkage, e.g. pushed or drawn through the pipes

Abstract

The present application provides a single-target pose estimation method and apparatus, and an electronic device. The single-target pose estimation method comprises: acquiring an image to be processed of a target; performing learning on image features in a receptive field in said image, and obtaining at least one local feature map, the local feature map reflecting local features of said image at different positions; on the basis of the at least one local feature map, establishing a relationship between image features in said image which exceed the receptive field, and obtaining a global feature map; performing feature fusion on each local feature map and the global feature map, and obtaining a key point information map; and on the basis of the key point information map, performing pose estimation of the target, and obtaining a pose estimation result, the pose estimation result comprising a key point position of the target in said image to be processed. In the present application, the technical problems in related technologies of low pose estimation accuracy and high model training costs can be solved.

IPC Classes  ?

• G06T 7/73 - Determining position or orientation of objects or cameras using feature-based methods
• G06V 40/10 - Human or animal bodies, e.g. vehicle occupants or pedestriansBody parts, e.g. hands

Abstract

The present application discloses a fusion protein and a use thereof in preparation of metabolites. The fusion protein comprises a localization peptide of a first subcellular structure and an ESCRT protein. For a host capable of expressing the fusion protein, the fusion protein can be located on the surface of the subcellular structure, the subcellular structure storing target metabolites enters a sorting link through an ESCRT path, finally enters an exosome and is secreted out of a cell, so that the extracellular yield of the target metabolites is effectively increased.

IPC Classes  ?

• C07K 19/00 - Hybrid peptides
• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/81 - Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
• C12N 15/62 - DNA sequences coding for fusion proteins

Abstract

An indoor positioning and navigation method based on the fusion of Wi-Fi fingerprint information and inertial sensor information. The method comprises: collecting Wi-Fi fingerprint data of a target device, and inputting the Wi-Fi fingerprint data into a trained fingerprint positioning model to obtain an observed global coordinate value; using an inertial sensor to collect an acceleration signal and an angular velocity signal of the target device, and inputting the acceleration signal and the angular velocity signal into a trained trajectory tracking model to obtain an observed relative displacement amount value, wherein the observed relative displacement amount value reflects a movement trajectory of the target device; and using extended Kalman filtering to fuse the observed global coordinate value and the observed relative displacement amount value to obtain fused position information as a positioning result of the target device. The method can effectively fuse inertial sensor information and received Wi-Fi fingerprint information which are integrated into a smart device, thereby improving the accuracy and robustness of indoor positioning.

IPC Classes  ?

• G01C 21/16 - NavigationNavigational instruments not provided for in groups by using measurement of speed or acceleration executed aboard the object being navigatedDead reckoning by integrating acceleration or speed, i.e. inertial navigation

Abstract

A pressure sensor, a manufacturing method, and a data acquisition system and method. The cylindrical array-type flexible pressure sensor comprises an ionic gel dielectric layer (2); the upper surface of the ionic gel dielectric layer (2) is provided with a plurality of column electrodes (1); the lower surface of the ionic gel dielectric layer (2) is provided with a plurality of row electrodes (3); the intersection of each row electrode (3) and each column electrode (1) forms a single sensor unit (4). The sensor and method can solve the problem of lack of touch information in the current digestive endoscopy diagnosis and treatment process, and have the characteristics of high sensitivity and accurate measurement.

IPC Classes  ?

• G01L 1/14 - Measuring force or stress, in general by measuring variations in capacitance or inductance of electrical elements, e.g. by measuring variations of frequency of electrical oscillators
• A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
• A61B 1/273 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor for the upper alimentary canal, e.g. oesophagoscopes, gastroscopes

Abstract

Provided in the present application is a preparation method for a silk fibroin hydrogel. The preparation method comprises the following steps: adding natural silk to a sodium carbonate solution, and heating the solution to obtain degummed natural silk; dissolving the degummed natural silk in a lithium bromide solution, and adding glycidyl methacrylate thereto to perform a reaction, so as to obtain a reaction solution; dialyzing the reaction solution to obtain a supernate; freeze-drying the supernate to obtain a freeze-dried protein; and mixing an antibacterial agent solution with a photoinitiator solution, adding the freeze-dried protein thereto, and irradiating same with blue-violet light to obtain a silk fibroin hydrogel. In the present application, glycidyl methacrylate is used to modify the degummed natural silk (fibroin); and an antibacterial agent and a photoinitiator are added in the hydrogel-forming step, and irradiation is performed with blue-violet light to subject the modified fibroin to curing crosslinking, thereby preparing a silk fibroin hydrogel having antibacterial performance, which hydrogel can be widely used in the fields of biomedical materials, etc. The preparation method of the present application is simple and fast, and has a high hydrogel-forming speed.

IPC Classes  ?

• C08F 299/00 - Macromolecular compounds obtained by interreacting polymers involving only carbon-to-carbon unsaturated bond reactions, in the absence of non-macromolecular monomers
• C08F 2/48 - Polymerisation initiated by wave energy or particle radiation by ultraviolet or visible light
• C08J 3/075 - Macromolecular gels
• C08L 55/00 - Compositions of homopolymers or copolymers, obtained by polymerisation reactions only involving carbon-to-carbon unsaturated bonds, not provided for in groups
• C08K 3/08 - Metals

Abstract

Provided are a Salmonella engineered cell-penetrating bacteriophage, and a construction method therefor and a use thereof. The Salmonella engineered cell-penetrating bacteriophage comprises a bacteriophage and a cell-penetrating peptide, the surface of the bacteriophage has a surface protein, the surface protein is fused with the cell-penetrating peptide, and the surface protein is a protein containing an Ig-like domain. By means of a bioinformatics method, proteins which are suitable for fusion expression with foreign proteins, namely proteins containing Ig-like domains, are screened out in a high-throughput manner from structural proteins of a Salmonella typhimurium bacteriophage, and then, fusion expression of a cell-penetrating peptide is implemented on the surface of the Salmonella typhimurium bacteriophage to obtain an engineered bacteriophage capable of efficiently killing Salmonella typhimurium in cells, thereby increasing the titer of the Salmonella typhimurium bacteriophage entering cells, and extending phage therapy to treatment of intracellular infections.

IPC Classes  ?

• C12N 7/01 - Viruses, e.g. bacteriophages, modified by introduction of foreign genetic material
• C12N 15/00 - Mutation or genetic engineeringDNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purificationUse of hosts therefor
• C12N 15/62 - DNA sequences coding for fusion proteins
• A61K 35/76 - VirusesSubviral particlesBacteriophages
• A61P 31/04 - Antibacterial agents
• C12R 1/92 - Viruses

Abstract

The present application relates to the technical field of image processing, and provides an image restoration method and apparatus, an electronic device and a storage medium. The method comprises: obtaining an image to be restored, and inputting the image to be restored into an image restoration network, wherein the image restoration network comprises a restoration stage and a generation stage; in the restoration stage, removing degradation in the image to be restored, so as to obtain a restored image; and in the generation stage, performing image detail supplementation on the restored image to obtain a target image. The present application solves the problem in image restoration related art that an image restoration method has insufficient generalization and poor robustness because the image restoration method cannot simultaneously realize image restoration on any image containing any degradation.

IPC Classes  ?

• G06T 5/00 - Image enhancement or restoration
• G06V 10/40 - Extraction of image or video features
• G06V 10/80 - Fusion, i.e. combining data from various sources at the sensor level, preprocessing level, feature extraction level or classification level
• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
• G06N 3/045 - Combinations of networks
• G06N 20/00 - Machine learning

Abstract

Disclosed is a modular mechanical free-clutch exoskeleton joint. The modular mechanical free-clutch exoskeleton joint comprises a first connecting ring, a second connecting ring, a bionic joint and a driving member; the bionic joint comprises a mounting base, a rotating ring and an eccentric block; the mounting base is connected to the second connecting ring, and the rotating ring is connected to the first connecting ring; the rotating ring is provided with a mounting groove, the eccentric block being rotatably connected in the mounting groove, and the mounting groove having an abutting and driving surface capable of abutting against the eccentric block; the driving member is mounted to the mounting base, and a driving shaft of the driving member has a transmission fit with the eccentric block, so as to drive the eccentric block to rotate; in the process of rotating, the eccentric block may drive the rotating ring to rotate, so as to drive the first connecting ring to rotate relative to the second connecting ring. The modular mechanical free-clutch exoskeleton joint is capable of switching, freely and without energy consumption, between power-assisted movement and free movement of any large joint of a limb of a human body, so that use safety, comfort, degree of coupling, flexibility and endurance of the exoskeleton joint are improved.

IPC Classes  ?

• B25J 17/00 - Joints
• B25J 19/00 - Accessories fitted to manipulators, e.g. for monitoring, for viewingSafety devices combined with or specially adapted for use in connection with manipulators

Abstract

The present invention relates to an automatic mouse food adding device that is convenient to move, comprising a support assembly, a transmission control assembly and a loading assembly. The support assembly comprises a box, universal wheels being provided at the bottom of the box. The loading assembly comprises a hopper, wherein a top cover is provided at the top of the hopper, a screw and a first electric motor are fixed inside the hopper, the lower portion of the screw extends into an outlet pipe below the hopper, a rotary piece is provided below the screw in the outlet pipe and is fixed in the outlet pipe by means of a rotary shaft, and the tail end of the outlet pipe is connected to a hose. The transmission control assembly comprises a vertical rod shaft and a second electric motor, wherein the bottom end of the vertical rod shaft is rotationally connected inside the box, the upper end of the vertical rod shaft is connected to a transverse support, and the hopper is fixed on the transverse support; and a driven gear is mounted on the vertical rod shaft, the second electric motor is fixed to the box, and an output shaft of the second electric motor is connected to a driving gear. By means of the present invention, during a cage changing process, dust formation is effectively avoided, and manual mouse food taking and adding links are omitted, thereby achieving automatic mouse food addition, shortening the time for adding mouse food to a single cage, and improving the operation efficiency.

IPC Classes  ?

• A01K 5/02 - Automatic devices

Abstract

A method and system for selecting an electrode startup contact for subthalamic nucleus (STN) deep brain stimulation, which method and system relate to the technical field of electroencephalogram data processing. The method comprises the following steps: firstly, collecting MERs signals of different brain regions of a patient to be tested (S1); respectively extracting time-sequence features and amplitude-sequence features from the MERs signals (S2); fusing the time-sequence features with the amplitude-sequence features, so as to obtain an amplitude-frequency perceptual fusion feature map of the MERs signals (S3); inputting the amplitude-frequency perceptual fusion feature map into an amplitude-frequency perceptual fusion network, and identifying the boundary of an STN and an optimal implantation position of a microelectrode, so as to determine the boundary of the STN and an implantation position of a permanent therapeutic electrode (S4); and analyzing the boundary of the STN and the implantation position of the permanent therapeutic electrode, so as to determine an optimal stimulation contact (S5). Thus, the problem of a postoperative optimal contact selection process requiring repeated tests and being time-consuming and effort-consuming is solved, thereby improving the postoperative program control efficiency, and reducing the dependence on the experience of clinicians.

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

Abstract

A method for measuring interface microscopic information of a polymer-based nano-precious metal composite material. The method comprises the following steps: a dual-beam Raman system collecting an interface Raman signal generated by plasmon resonance of a polymer-based nano-precious metal composite material (S1); the dual-beam Raman system collecting an intrinsic Raman signal of the polymer base (S2); the dual-beam Raman system collecting a pure polymer Raman signal of the same polymer material that does not contain a nano-precious metal (S3); performing comparative analysis on the interface Raman signal, the intrinsic Raman signal and the pure polymer Raman signal to obtain interface microscopic information (S4). According to the method, interface information of polymer/nano-precious metal composite materials can be accurately and nondestructively obtained by means of obtained interface Raman signals and intrinsic Raman signals.

IPC Classes  ?

• G01N 21/65 - Raman scattering
• G01N 21/64 - FluorescencePhosphorescence

Abstract

Disclosed in the present invention are an airbag-based protection apparatus and a control method. The apparatus comprises at least one airbag for protecting different body parts, a gas channel, a steering engine, an eccentric cam, a valve, a high-pressure gas cylinder, a motion sensor, a gas dynamic monitoring module and a first controller, wherein the first controller is used for controlling, when a target object falling down is determined according to motion data of the target object that is collected by the motion sensor, the steering engine to drive the eccentric cam to open the valve, so as to inflate the airbag, monitoring in real time a change in the volume of a gas in the high-pressure gas cylinder by means of the gas dynamic monitoring module, and when the volume of a gas reduced from the high-pressure gas cylinder is equal to the total gas volume of all airbags, controlling the steering engine to drive the eccentric cam to close the valve, so as to stop inflating. The present invention can perform personalized configuration on an airbag protection region according to requirements, and accurately inflate an airbag according to a change in the volume of a gas in a high-pressure gas cylinder without the need for frequently replacing the high-pressure gas cylinder, thereby improving the durability and practicability of the high-pressure gas cylinder.

IPC Classes  ?

• F17C 1/00 - Pressure vessels, e.g. gas cylinder, gas tank, replaceable cartridge
• F17C 13/02 - Special adaptations of indicating, measuring, or monitoring equipment
• F17C 13/04 - Arrangement or mounting of valves

Abstract

Disclosed in the present invention are a danger test case generation method for a visual perception algorithm, and a related device. The method comprises: acquiring images captured by a visual sensor of a self-driving vehicle, cleaning and marking the collected images, and obtaining an observation data set according to no-reference image quality evaluation features; according to the observation data set and by means of performing fusion with domain knowledge, constructing a causal structure diagram that indicates the influence of environmental factors on perception performance; separating key environmental factors from the causal structure diagram, and quantitatively calculating the degree of influence of each environmental factor on visual perception performance; and on the basis of qualitative analysis of a causal relationship between a key environment variable and the visual perception performance, and quantitative estimation of a causal effect, proposing a challenge index, so as to generate, in batches, danger test cases for perception. The present invention has significant advantages in multiple aspects such as causal relationship mining, challenge index measurement, dangerous-scenario recognition and search space modeling, such that the performance of a visual algorithm for self-driving in a complex environment is evaluated and verified more accurately.

IPC Classes  ?

• G06V 20/56 - Context or environment of the image exterior to a vehicle by using sensors mounted on the vehicle
• G06F 11/36 - Prevention of errors by analysis, debugging or testing of software

Abstract

The present application relates to the technical field of medicines. Disclosed are an NK nano pharmaceutical formulation, and a preparation method therefor and a use thereof. The NK nano pharmaceutical formulation comprises NK cells and a compound grafted on the surfaces of the NK cells and having a structural formula of (I).

IPC Classes  ?

• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
• A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
• A61K 35/17 - LymphocytesB-cellsT-cellsNatural killer cellsInterferon-activated or cytokine-activated lymphocytes
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A61P 25/16 - Anti-Parkinson drugs

Abstract

The present application is suitable for the technical field of data processing, and provides a data error correction method and apparatus and an electronic device. The method includes: decoding a base sequence to be subjected to error correction into a first text, the base sequence to be subjected to error correction being composed of a plurality of bases; performing word segmentation on the first text to obtain a plurality of text units; performing error detection on the plurality of text units to obtain a text unit having an error; and performing error correction on the base sequence to be subjected to error correction according to the text unit having the error. By means of the above method, error correction for data can be achieved, and the storage cost of DNA can also be reduced.

IPC Classes  ?

• G06F 40/279 - Recognition of textual entities
• G06F 11/10 - Adding special bits or symbols to the coded information, e.g. parity check, casting out nines or elevens

Abstract

Disclosed in the present invention is a radio frequency signal receiving system for magnetic resonance imaging. The system comprises: a low-temperature holding apparatus, a coil and a preamplifier, wherein the low-temperature holding apparatus is provided with a shell, a heat preservation cover and a vacuum layer. The shell wraps the vacuum layer; the vacuum layer comprises a vacuum area and a closed cavity surrounding the vacuum area, and the vacuum layer is in communication with a first vacuumizing port; and the coil is arranged in the closed cavity, and a signal generated by the coil is transmitted to a magnetic resonance system by means of the preamplifier. The radio frequency signal receiving system provided in the present invention has the advantages of being high in signal-to-noise ratio, wide in application, easy in operation, easy in maintenance, etc., and is suitable for imaging of multiple parts of a human body, such as knee joints, arms and wrists.

IPC Classes  ?

• G01R 33/36 - Electrical details, e.g. matching or coupling of the coil to the receiver

Abstract

The present invention relates to the field of geriatric treatment, in particular to the use of a matrix metalloproteinase inhibitor MSAB or a pharmaceutically acceptable salt thereof in the preparation of a drug for preventing or treating osteoarthritis cartilage injury. In the present invention, MSAB is used to inhibit the expression of matrix metalloproteinase in chondrocytes, so that the damage to articular cartilage structures is reduced, and the effect of preventing or treating osteoarthritis is achieved.

IPC Classes  ?

• A61K 31/245 - Amino benzoic acid types, e.g. procaine, novocaine
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
• A61P 19/08 - Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
• A61P 19/04 - Drugs for skeletal disorders for non-specific disorders of the connective tissue

Abstract

The present application relates to a real-time three-dimensional (3D) tumor tracking method and apparatus, and a computer device and a storage medium. The method comprises: acquiring a moving image and a reference image of a tumor site; performing hybrid data enhancement on the moving image and the reference image, so as to obtain a 3D CT image that represents each respiratory phase, and a segmented moving image; projecting the 3D CT image by using a ray casting algorithm, so as to generate a 2D DRR at a corresponding moment; and inputting the 2D DRR into a trained tumor tracking network, outputting a 3D deformation field of the 2D DRR by means of the tumor tracking network, and making the 3D deformation field act on the reference image, so as to generate a predicted segmented tumor image of the 2D DRR at the corresponding moment. In the embodiments of the present application, tumor tracking is performed on the basis of a single-angle X-ray image, such that the radiation dose is greatly reduced, high-precision tumor tracking performed at a low dose is realized, and the tumor tracking speed is significantly increased.

IPC Classes  ?

• G06T 7/00 - Image analysis
• A61N 5/00 - Radiation therapy

Abstract

Disclosed in the present invention are a terminal deoxynucleotidyl transferase mutant, and a composition thereof and a preparation method therefor. The terminal deoxynucleotidyl transferase mutant has an amino acid sequence as shown in SEQ ID NO: 1. Compared with a wild-type terminal deoxynucleotidyl transferase, the terminal deoxynucleotidyl transferase mutant provided in the present invention has a shorter amino acid sequence, a smaller volume of catalytic protein domain, and a relatively good catalytic activity.

IPC Classes  ?

• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
• C12N 15/70 - Vectors or expression systems specially adapted for E. coli
• C12N 15/54 - Transferases (2)
• C12R 1/19 - Escherichia coli

Abstract

A chemically modified nucleoside, a chemically modified nucleoside triphosphate, a chemical synthesis means and the use thereof, and a synthesized chemically modified nucleoside and a synthesized chemically modified nucleoside triphosphate. An mRNA obtained by replacing a natural nucleoside triphosphate in an mRNA with the chemically modified nucleoside triphosphate globally or in combination with other chemically modified nucleoside triphosphates has higher translation efficiency and stability, can reduce the immunogenicity, and provides supplementation and selection for mRNA modification technique.

IPC Classes  ?

• C07H 1/00 - Processes for the preparation of sugar derivatives
• C07H 19/10 - Pyrimidine radicals with the saccharide radical being esterified by phosphoric or polyphosphoric acids
• C07H 19/067 - Pyrimidine radicals with ribosyl as the saccharide radical
• C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
• C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 31/14 - Antivirals for RNA viruses

Abstract

The present application relates to the technical field of motors, and provides a matrix motor unit structure and a matrix motor. The matrix motor unit comprises at least two motor elements, and the motor elements are connected in an array form in a same plane and defined a motor main body structure. According to the matrix motor unit structure provided by the present application, the motor elements are compactly arranged, and a structure can be shared among the motor elements, so that the overall size and weight can be further reduced, and a higher output torque is obtained.

IPC Classes  ?

• H02K 7/20 - Structural association with auxiliary dynamo-electric machines, e.g. with electric starter motors or exciters
• H02K 1/14 - Stator cores with salient poles
• H02K 1/16 - Stator cores with slots for windings
• H02K 3/28 - Layout of windings or of connections between windings

Abstract

The present invention provides a chemically modified cytidine triphosphate and a preparation method therefor and a use thereof. According to the present invention, by using a chemical synthesis means, chemically modified cytidine and chemically modified cytidine triphosphate are synthesized, and natural cytidine triphosphate in an mRNA is simply replaced with the chemically modified cytidine triphosphate or is replaced with the combination of the chemically modified cytidine triphosphate and N1-methylpseudouridine triphosphate, so as to enhance the translation efficiency and stability of a target mRNA, reduce immunogenicity, and provide a supplement and new option for mRNA modification technology.

IPC Classes  ?

• C07H 19/10 - Pyrimidine radicals with the saccharide radical being esterified by phosphoric or polyphosphoric acids
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy

Abstract

A sheath tube having controllable stiffness, a control method therefor, and a surgical robot (30). The sheath tube having controllable stiffness comprises a sheath tube and a sheath tube control module connected to the sheath tube. The sheath tube comprises a head section (1), a transition section (2), a main body section (3) and a tail section (4), connected in sequence; the sheath tube control module comprises a stiffness control unit used to adjust the stiffness of the sheath tube, and a bending adjustment device (5) used to adjust a bending angle of the head section (1) of the sheath tube. The sheath tube having controllable stiffness has a bending adjustment function and a stiffness adjustment function, has a wide range of applications, is highly compatible with the surgical robot (30), can reduce operating skill requirements for a doctor, and ensures a stable surgical effect.

IPC Classes  ?

• A61B 34/30 - Surgical robots

Abstract

Provided are a method and apparatus for generating a quantitative physiological parameter map on the basis of magnetic resonance. The method comprises: acquiring each group of DCE-MRI images and a quantitative physiological parameter map corresponding to each group of DCE-MRI images; using each group of DCE-MRI images and the quantitative physiological parameter map as training inputs to train a deep learning model until the loss function value of the deep learning model meets a preset requirement, wherein the deep learning model is a generative adversarial network comprising a generation network and a discrimination network, the generation network is used for generating an output image, and the discrimination network comprises a global discriminator and a local discriminator; and using the deep learning model, of which the loss function value meets the preset requirement, as a quantitative physiological parameter map generation model, and processing a DCE-MRI image to be processed to obtain a quantitative physiological parameter map. The generation efficiency and accuracy of quantitative physiological parameter maps can be improved.

IPC Classes  ?

• G16H 30/00 - ICT specially adapted for the handling or processing of medical images

Abstract

The present application relates to the technical field of computer vision, and in particular to a font generation method and system based on a neural transformation field, a device, and a medium. The method comprises the following steps: on the basis of structural information of a source font, constructing neural transformation fields, wherein the positions in the neural transformation fields are in one-to-one correspondence with font styles, and each position represents a specific conversion; constructing a font style estimator and estimating the positions of the font styles in the neural transformation fields on the basis of the font style estimator; on the basis of the estimated positions and a font conversion path from the origin to the estimated positions, generating a plurality of sampling points and calculating the generation intensity and the dissipation rate of font pixels of the sampling points by means of the neural transformation fields; and obtaining intermediate conversion results, and accumulating the intermediate conversion results by means of a font rendering formula to obtain a target font image. The present application effectively solves the problem of lack of spatial transformation modeling during font style conversion in the existing methods, and improves the performance of the font generation method.

IPC Classes  ?

• G06F 40/109 - Font handlingTemporal or kinetic typography