Abstract

The present invention relates to resin-free ion-exchange using an electrode capacitor assembly comprising an anode and a cathode which are both functionalized with negatively charged groups.

IPC Classes  ?

• C02F 1/469 - Treatment of water, waste water, or sewage by electrochemical methods by electrochemical separation, e.g. by electro-osmosis, electrodialysis, electrophoresis
• C02F 1/461 - Treatment of water, waste water, or sewage by electrochemical methods by electrolysis
• C02F 103/08 - Seawater, e.g. for desalination
• H01G 11/30 - Electrodes characterised by their material

Abstract

The technology subject of the present application concerns an electrolyzer comprising a plurality of electrolysis cells and a method of generating hydrogen and oxygen gases.

IPC Classes  ?

• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• C25B 9/70 - Assemblies comprising two or more cells

Abstract

The present invention provides a self-healing biocompatible elastomer comprising polymeric chains comprising units of formula (A1), wherein R1 is selected from the group consisting of a linear (C2-C20) alkylene and —R4-S—S—R4′-, wherein R4 and R4′ are independently a linear (C1-C10) alkylene; R2 is a linear or cyclic (C4-C10) alkylene; and R3 is selected from the group consisting of a polybutadiene, a polybutene, a polyethylene, a polypropylene, and a polyisoprene, wherein the elastomer is crosslinked by hydrogen bonds between urethane linkages. Further provided is a one-pot method for preparing a self-healing biocompatible elastomer. The invention further provides an antibacterial composition and a wound dressing comprising the self-healing biocompatible elastomer. Formula (A1) The present invention provides a self-healing biocompatible elastomer comprising polymeric chains comprising units of formula (A1), wherein R1 is selected from the group consisting of a linear (C2-C20) alkylene and —R4-S—S—R4′-, wherein R4 and R4′ are independently a linear (C1-C10) alkylene; R2 is a linear or cyclic (C4-C10) alkylene; and R3 is selected from the group consisting of a polybutadiene, a polybutene, a polyethylene, a polypropylene, and a polyisoprene, wherein the elastomer is crosslinked by hydrogen bonds between urethane linkages. Further provided is a one-pot method for preparing a self-healing biocompatible elastomer. The invention further provides an antibacterial composition and a wound dressing comprising the self-healing biocompatible elastomer. Formula (A1)

IPC Classes  ?

• C08G 18/75 - Polyisocyanates or polyisothiocyanates cyclic cycloaliphatic
• A61L 15/26 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bondsDerivatives thereof
• C08G 18/10 - Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
• C08G 18/38 - Low-molecular-weight compounds having hetero atoms other than oxygen
• C08G 18/69 - Polymers of conjugated dienes

Abstract

The present invention provides a non-biological deionization fuel cell (DFC) comprising, inter alia, a cathode comprising a non-platinum group metal and a nitrogen doped carbon matrix. Further provided is a method of preparing the catalyst through a zeolitic imidazolate framework precursor.

IPC Classes  ?

• C02F 1/46 - Treatment of water, waste water, or sewage by electrochemical methods
• C02F 1/461 - Treatment of water, waste water, or sewage by electrochemical methods by electrolysis
• C02F 103/08 - Seawater, e.g. for desalination

Abstract

The present invention provides stem cells-derived extracellular vesicles (EVs) characterized by upregulation and/or downregulation of specific proteins. Composition comprising the EVs. and their use in the treatment of diseases and disorders associated with the upregulated proteins are also provided.

IPC Classes  ?

• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues

Abstract

The technology disclosed herein generally concerns a system and a process for continuous generation of hydrogen and oxygen gases.

IPC Classes  ?

• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• C25B 1/24 - Halogens or compounds thereof
• C25B 9/17 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof
• C25B 15/08 - Supplying or removing reactants or electrolytesRegeneration of electrolytes
• C01B 13/02 - Preparation of oxygen

Abstract

A full-duplex carrier aggregation RF wireless transceiver (100) is disclosed. The RF wireless transceiver (100) comprises a single transmit and receive antenna (110) configured to perform a RF transmission based on a transmit signal and to generate a receive signal based on a RF reception and a plurality of cascaded quadrature balanced power amplifier, QBPA, modules (120a-n), wherein each QBPA module (120a-n) comprises a transmit signal port (121a, b), an antenna port (122a, b), a receive signal port (123a, b), and a cancellation signal port (124a, b), wherein the antenna port (121a) of a first QBPA module (120a) is connected to the antenna (110) and wherein the antenna port (121b) of a second QBPA module (120b) is connected to the receive signal port of the first QBPA module (120a). Each QBPA module (120a-n) is configured to: receive a transmit input signal at the transmit signal port (121a, b); receive a receive signal at the antenna port (122a, b); receive a cancellation input signal at the cancellation signal port (124a, b); generate a transmit signal based on the transmit input signal and output the transmit signal via the antenna port (122a, b); generate a cancellation signal based on the cancellation input signal and output the cancellation signal and the receive signal at the receive signal port (123a, b).

IPC Classes  ?

• H04B 1/525 - Hybrid arrangements, i.e. arrangements for transition from single-path two-direction transmission to single-direction transmission on each of two paths or vice versa with means for reducing leakage of transmitter signal into the receiver
• H03F 3/62 - Two-way amplifiers
• H04B 1/00 - Details of transmission systems, not covered by a single one of groups Details of transmission systems not characterised by the medium used for transmission
• H03F 1/32 - Modifications of amplifiers to reduce non-linear distortion
• H03F 1/56 - Modifications of input or output impedances, not otherwise provided for
• H03F 3/60 - Amplifiers in which coupling networks have distributed constants, e.g. with waveguide resonators

Abstract

A RF wireless transceiver (100) for full-duplex communication is disclosed. The RF wireless transceiver (100) comprises a single transmit and receive antenna (110) configured to perform a RF transmission based on a transmit signal and to generate a receive signal based on a RF reception. Moreover, the RF wireless transceiver (100) comprises a quadrature balanced power amplifier, QBPA, module (120), wherein the QBPA module (120) comprises a transmit signal port (121), an antenna port (122) connected to the antenna (110), a receive signal port (123), and a cancellation signal port (124), and wherein the QBPA module (120) is configured to: receive a transmit input signal at the transmit signal port (121); receive a receive signal at the antenna port (122); generate a transmit signal based on the transmit input signal and output the transmit signal via the antenna port (122); and reflect a portion of the transmit signal to the cancellation signal port (124). The RF wireless transceiver (100) further comprises a cancellation input signal generator (130) configured to generate, based on the reflected portion of the transmit signal, a cancellation input signal at the cancellation signal port (124) of the QPBA module (120). The QBPA module (120) is further configured to generate a cancellation signal based on the cancellation input signal and output the receive signal and the cancellation signal at the receive signal port (123) for nulling transmission leakage.

IPC Classes  ?

• H04B 1/525 - Hybrid arrangements, i.e. arrangements for transition from single-path two-direction transmission to single-direction transmission on each of two paths or vice versa with means for reducing leakage of transmitter signal into the receiver
• H03F 3/62 - Two-way amplifiers
• H04B 1/04 - Circuits
• H03F 1/32 - Modifications of amplifiers to reduce non-linear distortion
• H03F 1/56 - Modifications of input or output impedances, not otherwise provided for
• H03F 3/60 - Amplifiers in which coupling networks have distributed constants, e.g. with waveguide resonators

Abstract

The present invention provides inhibitory molecules for inhibiting or at least partially preventing the binding of influenza virus hemagglutinin (HA) with Lymphocyte activation gene 3 (LAG-3) glycoprotein, for the treatment of influenza virus in a subject. The inhibition of this interaction may be achieved by binding to HA and/or by binding to LAG-3, e.g., by an antibody that binds specifically to the domain in LAG-3 that interacts with HA. The present invention also provides an antibody, or an antibody fragment thereof comprising at least the antigen binding portion, which specifically binds to an N- glycosylation site within human LAG-3, and use of the antibody or fragment thereof in treatment of a disease selected from cancer, autoimmune disease, inflammatory disease and a CNS disease.

IPC Classes  ?

• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61P 31/12 - Antivirals
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants

Abstract

The technology subject of the present application concerns a water treatment system utilizing hexacyanoferrate salts.

IPC Classes  ?

• C02F 1/28 - Treatment of water, waste water, or sewage by sorption
• A01K 63/04 - Arrangements for treating water specially adapted to receptacles for live fish
• C02F 1/00 - Treatment of water, waste water, or sewage
• C02F 1/66 - Treatment of water, waste water, or sewage by neutralisationTreatment of water, waste water, or sewage pH adjustment

Abstract

The present invention provides a pharmaceutical composition including one or more cannabinoids, and methods of using same, such as for treating estrogen receptor-related diseases. The present invention further provides combination therapy comprising one or more cannabinoids and an estrogen receptor activation inhibitor and use thereof in sensitizing subjects that are resistance to treatment with the estrogen receptor activation inhibitor alone.

IPC Classes  ?

• A61K 31/00 - Medicinal preparations containing organic active ingredients
• A61K 31/135 - Amines, e.g. amantadine having aromatic rings, e.g. methadone
• A61P 15/00 - Drugs for genital or sexual disordersContraceptives
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention provides a composite material and a sensing platform unit comprising a self-healing polymer matrix and at least two conductive nanomaterials embedded therein. The polymer matrix has a multi-layer structure comprising a first layer comprising a network of a first nanomaterial, which resistance changes in response to a mechanical damage inflicted on the polymer matrix; and a second layer comprising a network of a second nanomaterial, configured to generate heat under applied voltage. The network of the first nanomaterial and the network of the second nanomaterial are electrically connected to a mutual control circuit which is configured to apply voltage to the second nanomaterial upon a change in resistance of the first nanomaterial. The sensing platform unit further comprises a third layer comprising a network of a third nanomaterial configured to detect at least one of pressure, strain, temperature, pH, humidity, and volatile organic compounds (VOCs).

IPC Classes  ?

• C08J 7/044 - Forming conductive coatingsForming coatings having anti-static properties
• G01N 27/12 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon absorption of a fluidInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon reaction with a fluid
• C08K 3/04 - Carbon

Abstract

The present invention provides methods of diagnosing cancer in a test subject, comprising exposing an array of chemically sensitive sensors comprising a material selected from the group consisting of conductive nanostructures coated with an organic coating, a conducting polymer and a conductive polymer composite, to a blood sample and a urine sample obtained from the test subject, and analyzing output signals of the chemically sensitive sensors upon exposure of the array to the blood sample and the urine sample. The array of the chemically sensitive sensors can be a part of a portable medical device. Further provided is a method of diagnosing cancer in a test subject, comprising measuring and analyzing levels of a set of volatile organic compounds (VOCs) in a blood sample and a urine sample obtained from the test subject.

IPC Classes  ?

• G01N 27/327 - Biochemical electrodes
• G01N 1/22 - Devices for withdrawing samples in the gaseous state
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients

Abstract

The present disclosure provides devices, systems, kits and methods for rapid, simple self-sampling and self-performing detection of nucleic acid sequence of interest in a sample, specifically, nucleic acid sequences of pathogenic agents.

IPC Classes  ?

• C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving virus or bacteriophage
• B01L 7/00 - Heating or cooling apparatusHeat insulating devices
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

The disclosure relates to ternary dumb bell-shaped nanowire semiconductors for photocatalysis. Specifically, the disclosure relates to ternary dumbbell-shaped nanowire (TDNWs) semiconductors symmetrically decorated with a core-shell co-catalyst for photocatalys, methods for synthesis thereof and methods for generating hydrogen using the TDNWs.

IPC Classes  ?

• B01J 35/00 - Catalysts, in general, characterised by their form or physical properties
• B01J 23/06 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of zinc, cadmium or mercury
• B01J 23/28 - Molybdenum
• B01J 23/46 - Ruthenium, rhodium, osmium or iridium
• B01J 27/057 - Selenium or telluriumCompounds thereof
• H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof

Abstract

The present invention provides a pharmaceutical composition including one or more cannabinoids, and methods of using same, such as for treating NOTCH-related diseases.

IPC Classes  ?

• A61K 31/00 - Medicinal preparations containing organic active ingredients
• A61P 17/06 - Antipsoriatics
• A61P 35/00 - Antineoplastic agents

Abstract

Disclosed, in various exemplary implementations, are systems and methods for water photocatalysis using shaped semiconductor (or photo-induced charge carriers) immobilized on optionally removable transparent membranes under a closed redox cycle. Provided herein is a system for continuously generating hydrogen; a pressurized water source in continuous liquid communication with a first inlet; a pressurized source of an electron donor compound; and at least one removable transparent membrane comprising a plurality of at least partially embedded shaped nanoscale semiconductors, each having a basal end and an apical end, with a seed embedded within the shaped nanoscale semiconductors at the basal end, and a metal tip disposed at the apical end of the shaped nanoscale semiconductors.

IPC Classes  ?

• C01B 3/02 - Production of hydrogen or of gaseous mixtures containing hydrogen
• C01B 13/02 - Preparation of oxygen
• C25B 1/04 - Hydrogen or oxygen by electrolysis of water

Abstract

The invention disclosed herein generally contemplates novel microelectrodes and methods of preparing same.

IPC Classes  ?

• C25B 1/02 - Hydrogen or oxygen
• C25B 11/031 - Porous electrodes
• C25B 11/061 - Metal or alloy
• C25B 11/067 - Inorganic compound e.g. ITO, silica or titania

Abstract

The invention disclosed herein concerns an amperometric enzyme-based biosensor which exhibits high accuracy, high bioelectrocatalytic currents, linear response, low overpotentials and stability.

IPC Classes  ?

• G01N 27/327 - Biochemical electrodes

Abstract

The present invention provides pharmaceutical compositions comprising membrane vesicles, including extracellular vesicles including those referred to as exosomes, loaded with an exogenous Phosphatase and tensin homolog (PTEN) inhibitor. Methods of treating neurological diseases, disorders or conditions using the extracellular vesicles are provided. Isolated extracellular vesicles loaded with an exogenous Phosphatase and tensin homolog (PTEN) inhibitor are provided as well.

IPC Classes  ?

• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61K 35/28 - Bone marrowHaematopoietic stem cellsMesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• A61K 38/51 - Lyases (4)
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 9/50 - Microcapsules
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof

Abstract

Provided is a system for continuous generation of gases, the system including an electrochemical device and an active- material regeneration device.

IPC Classes  ?

• C25B 9/13 - Single electrolytic cells with circulation of an electrolyte
• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• C25B 9/30 - Cells comprising movable electrodes, e.g. rotary electrodesAssemblies of constructional parts thereof
• C25B 9/40 - Cells or assemblies of cells comprising electrodes made of particlesAssemblies of constructional parts thereof
• C25B 15/08 - Supplying or removing reactants or electrolytesRegeneration of electrolytes

Abstract

Micelles of peptidic conjugates of SN-38 loaded with one or more free therapeutic active agents which anticancer activity,such as free SN-38 lactone, process for their preparation, pharmaceutical compositions comprising them, and their therapeutical indications as anticancer drugs.

IPC Classes  ?

• A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention provides methods and systems for enhanced production and/or secretion of extracellular vesicles (EVs) from muscle cells utilizing various dynamic mechanical loading profiles thereon, cultured on three-dimensional (3D) scaffolds. The scaffolds may comprise a plurality of layers, wherein each layer comprises a plurality of elastic microfibers, and wherein the microfibers are aligned in parallel to a longitudinal axis and to each other. The elastic 3D scaffold may be configured to undergo dynamic mechanical loading profiles and support an expansion of a population of muscle cells cultured thereon into a 3D multi-layer structure of muscle cells, wherein said 3D multi-layer structure is configured to produce and/or secret extracellular vesicles into a medium.

IPC Classes  ?

• C12N 5/077 - Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
• C12M 1/42 - Apparatus for the treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic wave
• C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means

Abstract

A novel structural arrangement for the various components of an Ultra-Micro Gas Turbine Generator, based on a single part impeller element which comprises the compressor, the turbine and the electrical generator core in a single annular structure, produced as a single piece by an additive manufacturing process. The single annular structure has a hollow shell structure, with a supporting structure within in. The internal hollow space of the shell structure provides for a flow of cooling air from the outside through the internal space, for cooling the turbine region of the impeller. This air flow could be assisted by the use of internal blades, which can also serve as the supporting structure to increase the strength of the shell structure. The air flow can either be ejected at the center of the turbine, or can provide a high pressure supply for air bearings of the impeller element.

IPC Classes  ?

• F02C 3/045 - Gas-turbine plants characterised by the use of combustion products as the working fluid having a turbine driving a compressor having compressor and turbine passages in a single rotor
• F01D 15/10 - Adaptations for driving, or combinations with, electric generators
• F02K 1/00 - Plants characterised by the form or arrangement of the jet pipe or nozzleJet pipes or nozzles peculiar thereto
• F01D 25/12 - Cooling
• F01D 5/08 - Heating, heat-insulating, or cooling means

Abstract

A transistor structure is presented comprising: an organic semiconductor channel region, and source and drain electrodes in electrical contact with said organic semiconductor channel region, wherein at least one of said source and drain electrodes is formed by spaced apart regions of a first metallic material separated by regions of a second metallic material such that regions of the first and second metallic materials are in contact with the organic semiconductor channel region, said first metallic material being selected as having work function substantially similar to HOMO energy level of said organic semiconductor channel region and said second metallic material being selected as having work function substantially similar to LUMO energy level of said organic semiconductor channel region, thereby enabling selective injections of electrons or holes into said channel region.

IPC Classes  ?

• H10K 10/46 - Field-effect transistors, e.g. organic thin-film transistors [OTFT]
• H10K 19/10 - Integrated devices, or assemblies of multiple devices, comprising at least one organic element specially adapted for rectifying, amplifying, oscillating or switching, covered by group comprising field-effect transistors

Abstract

A laser source is presented a plurality of unit cells of a selected number of partially physically coupled lasing units arranged within a plane and configured to form a topological structure, wherein each of the lasing units is configured to emit radiation component substantially perpendicular to said plane, said plurality of the unit cells comprising at least a first sub-array of the unit cells located in a first region interfacing with a second region of a different type than said first region, thereby defining an arrangement of optically coupled lasing units along an interface region between the first and second adjacent regions, forming at least one topological state along a topological path within said interface region.

IPC Classes  ?

• H01S 5/00 - Semiconductor lasers
• H01S 5/42 - Arrays of surface emitting lasers

Abstract

The present invention relates to pharmaceutical compositions containing certain phytocannabinoids and their use in treating or preventing headaches, particularly migraine headaches.

IPC Classes  ?

• A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
• A61P 25/06 - Antimigraine agents
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

The present invention provides a self-healing biocompatible elastomer comprising polymeric chains comprising units of formula (Al), wherein R1 is selected from the group consisting of a linear (C2-C20) alkylene and — R4-S-S- R4' —, wherein R4 and R4' are independently a linear (C1-C10) alkylene; R2 is a linear or cyclic (C4-C10) alkylene; and R3 is selected from the group consisting of a polybutadiene, a polybutene, a polyethylene, a polypropylene, and a polyisoprene, wherein the elastomer is crosslinked by hydrogen bonds between urethane linkages. Further provided is a one-pot method for preparing a self- healing biocompatible elastomer. The invention further provides an antibacterial composition and a wound dressing comprising the self-healing biocompatible elastomer. Formula (A1)

IPC Classes  ?

• C08G 18/10 - Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
• C08G 18/69 - Polymers of conjugated dienes
• C08G 18/75 - Polyisocyanates or polyisothiocyanates cyclic cycloaliphatic
• C09D 175/14 - Polyurethanes having carbon-to-carbon unsaturated bonds
• G01N 27/12 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon absorption of a fluidInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon reaction with a fluid
• G01N 27/414 - Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS

Abstract

The invention proposes an approach utilizing novel and artificially intelligent hybrid sensor arrays with multiplexed detection capabilities for disease-specific biomarkers from the exhaled breath of a subject. The technology provides a rapid and highly accurate diagnosis in various COVID-19 infection and transmission scenarios.

IPC Classes  ?

• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• A61B 5/08 - Measuring devices for evaluating the respiratory organs

Abstract

The present disclosure provides a device and system for detecting and/or measuring a constituent of an interstitial fluid from the skin of a subject. The device is a wearable extended gate field effect transistor (EGFET) device comprising a polymeric substrate for fixing to the skin of the subject; an extended gate electrode comprising a first microneedle configured for accessing the interstitial fluid and a first electric contact, wherein the first microneedle and the first electric contact are disposed on the polymeric substrate; and a field effect transistor (FET) associated with the first microneedle through the first electric contact. Further provided are a method for detecting and/or measuring a constituent of an interstitial fluid from the skin of a subject involving the use of the system and a method for fabricating the EGFET device.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
• A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
• A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
• G01N 27/327 - Biochemical electrodes
• G01N 27/414 - Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS

Abstract

A self-healing field-effect transistor (FET) device is disclosed in this application, the self-healing FET has a self-healing substrate, a self-healing dielectric layer, a gate electrode, at least one source electrode, at least one drain electrode, and at least one channel. The self-healing substrate and the self-healing dielectric layer have a disulfide-containing poly(urea-urethane) (PUU) polymer. The self-healing dielectric layer has a thickness of less than about 10 μm. The electrodes have electrically conductive elongated nanostructures. The at least one channel has semi-conducting elongated nanostructures.

IPC Classes  ?

• H01L 29/78 - Field-effect transistors with field effect produced by an insulated gate
• H01L 29/06 - Semiconductor bodies characterised by the shapes, relative sizes, or dispositions of the semiconductor regions
• H01L 29/16 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only elements of Group IV of the Periodic System in uncombined form
• H01L 29/24 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only inorganic semiconductor materials not provided for in groups , ,  or
• H01L 29/423 - Electrodes characterised by their shape, relative sizes or dispositions not carrying the current to be rectified, amplified or switched
• H01L 29/66 - Types of semiconductor device
• H01L 29/786 - Thin-film transistors

Abstract

The present invention provides a non-biological deionization fuel cell (DFC) comprising, inter alia, a cathode comprising a non-platinum group metal and a nitrogen doped carbon matrix. Further provided is a method of preparing the catalyst through a zeolitic imidazolate framework precursor.

IPC Classes  ?

• B01D 61/46 - Apparatus therefor
• C02F 1/46 - Treatment of water, waste water, or sewage by electrochemical methods
• C02F 1/461 - Treatment of water, waste water, or sewage by electrochemical methods by electrolysis
• C02F 1/469 - Treatment of water, waste water, or sewage by electrochemical methods by electrochemical separation, e.g. by electro-osmosis, electrodialysis, electrophoresis
• H01M 8/08 - Fuel cells with aqueous electrolytes
• H01M 8/22 - Fuel cells in which the fuel is based on materials comprising carbon or oxygen or hydrogen and other elementsFuel cells in which the fuel is based on materials comprising only elements other than carbon, oxygen or hydrogen

Abstract

A method for automatic determining of a state of a heart of a patient based on multiple-lead ECG information of the patient, the method includes (a) receiving the multiple-lead ECG information of the patient, by a computerized system; and (b) applying one or more machine learning processes on the multiple-lead ECG information of the patient to determine the state of a heart of the patient, wherein the state of the heart comprises at least one heart condition of multiple types of heart conditions. One, some or all of the one or more machine learning processes was trained using a dataset that comprises multiple computer generated images, the multiple computer generated images represent images acquired by an image acquisition process of ECG plots, wherein the ECG plots are generated based on digital multiple-lead ECG signals.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G06T 7/00 - Image analysis
• A61B 5/349 - Detecting specific parameters of the electrocardiograph cycle

Abstract

There may be provided method for estimating an information unit represented by a cluster of traces that are noisy copies of a synthesized strand, the method may include estimating the information unit by applying processing operations on r-tuples related to the traces, wherein r is smaller than a number (t) of traces of the cluster; wherein processing operations applied on at least some of the r-tuples comprise calculating a length of a shortest common supersequences (SCS) of the r-tuples.

IPC Classes  ?

• G16B 50/30 - Data warehousingComputing architectures
• G06N 3/12 - Computing arrangements based on biological models using genetic models

Abstract

A molecular data storage system is presented for encoding data-block(s). The system includes one or more populations of molecular sequences, each population encoding a respective one of the data-blocks. Each molecular sequence comprises a data encoding section comprising a sequence of similar predetermined length N of short k-mers, whereby in each population the data encoding sections of all molecular sequences have the similar predetermined length N. The short k-mers serve as data encoding building blocks of the data encoding sections, whereby valid short k-mers serving as data encoding building blocks form a subset of a building-block-set consisting of a number Z of different preselected short k-mers each presenting a unique combination of a number k of bases of a preselected set of bases, characterized in that all the Z types of short k-mers in said building-block-set have a similar predetermined size k≥2 (plurality) of bases. The data encoding sections collectively encode a sequence of encoded alphabet letters S=(π1, π2, . . . , πn . . . , πN−1, πN). Each valid encoded alphabet letter πn at location n of the sequence S of alphabet letters is characterized by occurrence of a predetermined plurality of different types of short k-mers of the building-block-set in a corresponding location n along the data encoding sections of the plurality of molecular sequences of said population.

IPC Classes  ?

• G06N 3/12 - Computing arrangements based on biological models using genetic models
• G16B 30/00 - ICT specially adapted for sequence analysis involving nucleotides or amino acids

Abstract

The technology subject of the present application concerns a water treatment system utilizing hexacyanoferrate salts.

IPC Classes  ?

• C02F 1/28 - Treatment of water, waste water, or sewage by sorption
• C02F 1/58 - Treatment of water, waste water, or sewage by removing specified dissolved compounds
• A01K 63/02 - Receptacles specially adapted for transporting live fish
• A01K 63/04 - Arrangements for treating water specially adapted to receptacles for live fish
• B01J 20/02 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material
• B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
• C02F 1/44 - Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis
• C02F 1/66 - Treatment of water, waste water, or sewage by neutralisationTreatment of water, waste water, or sewage pH adjustment
• C02F 3/04 - Aerobic processes using trickle filters
• C02F 3/06 - Aerobic processes using submerged filters
• C02F 101/16 - Nitrogen compounds, e.g. ammonia
• C02F 103/08 - Seawater, e.g. for desalination
• C02F 103/20 - Nature of the water, waste water, sewage or sludge to be treated from animal husbandry

Abstract

The present invention discloses a scintillator structure and to a method for producing an output optical signal at a specific wavelength range. The scintillator structure comprises a multilayer nanostructure formed by at least one pair of alternating first and second layered material being arranged along one or more principal axes. The multi-layer nanostructure defines predetermined geometrical parameters and the structure is made of at least two different material compositions. At least one of the first layered material, the second layered material, or the combination of both, define scintillation properties. The invention also discloses a detector system for detecting an input radiation comprising a scintillator structure being as defined above and being configured and operable to collect most of the emitted optical signal.

IPC Classes  ?

• G01T 1/20 - Measuring radiation intensity with scintillation detectors
• G01T 1/202 - Measuring radiation intensity with scintillation detectors the detector being a crystal

Abstract

Provided herein are modified forms of Conantokin peptides, including, modified Con-P peptides, nucleic acids encoding the same and compositions thereof. Further provided are nucleic acid molecules encoding for chimeric modified conantokin polypeptides to be expressed in or on a membrane of a target cells, compositions comprising the same and uses thereof for treating various neurodegenerative conditions.

IPC Classes  ?

• C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

The present invention relates to the field of phenotyping, particularly to systems and methods for collecting, retrieval and processing of data for accurate and sensitive analysis and prediction of a phenotype of an object, particularly of a plant.

IPC Classes  ?

• G01N 21/27 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
• G01N 33/02 - Food
• G01S 17/894 - 3D imaging with simultaneous measurement of time-of-flight at a 2D array of receiver pixels, e.g. time-of-flight cameras or flash lidar
• G01S 17/86 - Combinations of lidar systems with systems other than lidar, radar or sonar, e.g. with direction finders
• G01N 21/25 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
• G06V 10/143 - Sensing or illuminating at different wavelengths
• G06V 10/147 - Details of sensors, e.g. sensor lenses
• G06V 10/80 - Fusion, i.e. combining data from various sources at the sensor level, preprocessing level, feature extraction level or classification level
• G06V 10/40 - Extraction of image or video features
• G06V 10/20 - Image preprocessing
• G06T 7/30 - Determination of transform parameters for the alignment of images, i.e. image registration
• H04N 5/247 - Arrangement of television cameras
• H04N 5/232 - Devices for controlling television cameras, e.g. remote control
• G06V 10/774 - Generating sets of training patternsBootstrap methods, e.g. bagging or boosting
• G06T 7/00 - Image analysis
• G06V 20/10 - Terrestrial scenes

Abstract

A thermochemical recuperation (TCR) system that may use a water-alcohol mixture as an engine liquid coolant; that may include a TCR reformer configured to output a TCR product at pressure no less than twenty bars; a pressure regulator; and an TCR product accumulator configured to separate an outputting of the TCR product by the TCR reformer from a provision of the TCR product to the pressure regulator; wherein the pressure regulator is configured to provide the TCR product to a direct injector of an engine, thereby enabling the direct injector to inject the TCR product at a high pressure level—for example at a pressure level that exceeds twenty bars.

IPC Classes  ?

• F02M 21/02 - Apparatus for supplying engines with non-liquid fuels, e.g. gaseous fuels stored in liquid form for gaseous fuels
• F01P 3/20 - Cooling circuits not specific to a single part of engine or machine
• F01P 5/10 - Pumping liquid coolantArrangements of coolant pumps
• F01P 3/02 - Arrangements for cooling cylinders or cylinder heads
• F01P 7/16 - Controlling of coolant flow the coolant being liquid by thermostatic control
• F01N 5/02 - Exhaust or silencing apparatus combined or associated with devices profiting by exhaust energy the devices using heat
• F02G 5/02 - Profiting from waste heat of exhaust gases

Abstract

The present invention provides stem cells-derived extracellular vesicles (EVs) characterized by upregulation and/or downregulation of specific proteins. Composition comprising the EVs, and their use in the treatment of diseases and disorders associated with the upregulated proteins are also provided.

IPC Classes  ?

• A61K 35/00 - Medicinal preparations containing materials or reaction products thereof with undetermined constitution
• A61K 35/28 - Bone marrowHaematopoietic stem cellsMesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• A61K 35/12 - Materials from mammalsCompositions comprising non-specified tissues or cellsCompositions comprising non-embryonic stem cellsGenetically modified cells
• A61K 35/30 - NervesBrainEyesCorneal cellsCerebrospinal fluidNeuronal stem cellsNeuronal precursor cellsGlial cellsOligodendrocytesSchwann cellsAstrogliaAstrocytesChoroid plexusSpinal cord tissue
• A61K 35/545 - Embryonic stem cellsPluripotent stem cellsInduced pluripotent stem cellsUncharacterised stem cells
• C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
• C12M 1/42 - Apparatus for the treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic wave
• C12M 1/00 - Apparatus for enzymology or microbiology
• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues

Abstract

The present invention provides a solution-processable self-healing hydrolytically stable elastomer, a method for the preparation thereof, and articles of manufacture comprising the elastomer. The elastomer comprises polymeric chains comprising units of formula (A1), wherein R is a polybutadiene-containing polyurethane; R1 and R1′ are independently selected from the group consisting of: —H, (C1-C20)alkyl, (C5-C14)aryl, —OR4, —(CO)R5, —O(CO)R6, —(SO)R7, CO—R8, —COOR9, —NO2, and halogen; R2, R2′, R3 and R3′ are independently selected from the group consisting of: —H, (C1-C20)alkyl, and (C5-C14)aryl; R4 to R9 are the same or different, and are independently selected from the group consisting of: —H, (C1-C20)alkyl, and (C5-C14)aryl; m is 4; wherein the elastomer is dynamically crosslinked by aromatic disulfide metathesis, and wherein the elastomer has a water contact angle of above 100 #. The present invention provides a solution-processable self-healing hydrolytically stable elastomer, a method for the preparation thereof, and articles of manufacture comprising the elastomer. The elastomer comprises polymeric chains comprising units of formula (A1), wherein R is a polybutadiene-containing polyurethane; R1 and R1′ are independently selected from the group consisting of: —H, (C1-C20)alkyl, (C5-C14)aryl, —OR4, —(CO)R5, —O(CO)R6, —(SO)R7, CO—R8, —COOR9, —NO2, and halogen; R2, R2′, R3 and R3′ are independently selected from the group consisting of: —H, (C1-C20)alkyl, and (C5-C14)aryl; R4 to R9 are the same or different, and are independently selected from the group consisting of: —H, (C1-C20)alkyl, and (C5-C14)aryl; m is 4; wherein the elastomer is dynamically crosslinked by aromatic disulfide metathesis, and wherein the elastomer has a water contact angle of above 100 #.

IPC Classes  ?

• C08G 75/14 - Polysulfides
• G01L 1/22 - Measuring force or stress, in general by measuring variations in ohmic resistance of solid materials or of electrically-conductive fluidsMeasuring force or stress, in general by making use of electrokinetic cells, i.e. liquid-containing cells wherein an electrical potential is produced or varied upon the application of stress using resistance strain gauges
• G01N 27/414 - Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS

Abstract

The present invention relates to a paste comprising amorphous calcium carbonate (ACC) doped with divalent alkaline-earth metal ions, e.g., magnesium ions, or transition metal ions: a dry three-dimensional model made of such a paste, e.g., by 3D-printing process such as robocasting 3D-printing process; and a process for the preparation of said paste.

IPC Classes  ?

• C04B 22/10 - Acids or salts thereof containing carbon in the anion, e.g. carbonates
• C04B 26/04 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
• B28B 1/00 - Producing shaped articles from the material
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 70/00 - Materials specially adapted for additive manufacturing
• B33Y 80/00 - Products made by additive manufacturing
• B33Y 40/20 - Post-treatment, e.g. curing, coating or polishing

Abstract

The present invention provides a pharmaceutical composition including one or more cannabinoids, and methods of using same, such as for treating estrogen receptor-related diseases. The present invention further provides combination therapy comprising one or more cannabinoids and an estrogen receptor activation inhibitor and use thereof in sensitizing subjects that are resistance to treatment with the estrogen receptor activation inhibitor alone.

IPC Classes  ?

• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61K 31/138 - Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
• A61P 35/00 - Antineoplastic agents
• A61P 5/32 - Antioestrogens

Abstract

The present invention provides methods of diagnosing cancer in a test subject, comprising exposing an array of chemically sensitive sensors comprising a material selected from the group consisting of conductive nanostructures coated with an organic coating, a conducting polymer and a conductive polymer composite, to a blood sample and a urine sample obtained from the test subject, and analyzing output signals of the chemically sensitive sensors upon exposure of the array to the blood sample and the urine sample. The array of the chemically sensitive sensors can be a part of a portable medical device. Further provided is a method of diagnosing cancer in a test subject, comprising measuring and analyzing levels of a set of volatile organic compounds (VOCs) in a blood sample and a urine sample obtained from the test subject.

IPC Classes  ?

• G01N 33/497 - Physical analysis of biological material of gaseous biological material, e.g. breath
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G01N 27/414 - Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
• G01N 30/88 - Integrated analysis systems specially adapted therefor, not covered by a single one of groups
• A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
• G01N 30/02 - Column chromatography
• G01N 30/72 - Mass spectrometers

Abstract

The present invention provides a composite material and a sensing platform unit comprising a self-healing polymer matrix and at least two conductive nanomaterials embedded therein. The polymer matrix has a multi-layer structure comprising a first layer comprising a network of a first nanomaterial, which resistance changes in response to a mechanical damage inflicted on the polymer matrix; and a second layer comprising a network of a second nanomaterial, configured to generate heat under applied voltage. The network of the first nanomaterial and the network of the second nanomaterial are electrically connected to a mutual control circuit which is configured to apply voltage to the second nanomaterial upon a change in resistance of the first nanomaterial. The sensing platform unit further comprises a third layer comprising a network of a third nanomaterial configured to detect at least one of pressure, strain, temperature, pH, humidity, and volatile organic compounds (VOCs).

IPC Classes  ?

• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• G01N 27/12 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon absorption of a fluidInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon reaction with a fluid
• C08K 3/08 - Metals

Abstract

A device comprising: plurality of Stationary Nanoliter Droplet Array (SNDA) components; each SNDA component comprising: at least one primary channel; at least one secondary channel; and a plurality of nano-wells that are each open to the primary channel and are each connected by one or more vents to the secondary channel; the vents are configured to enable passage of air solely from the nano-wells to the secondary channel, such that when a liquid is introduced into the primary channel it fills the nano-wells, and the originally accommodated air is evacuated via the vents and the secondary channel/s; an inlet port and a distribution channel configured to enable a simultaneous introduction of the liquid into all primary channels; and an outlet port and an evacuation channel configured to enable a simultaneous evacuation of the air out of all the secondary channels.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

An optical digital to analog converter (oDAC) that may include (a) multiple optical paths that are parallel to each other; (b) a combiner, (c) a splitter that is configured to receive an optical signal at a splitter input and split the optical signal between multiple splitter outputs to provide multiple path input signals to the multiple optical paths. The multiple optical paths are configured to optically process, in parallel, path input signals to provide path output signals. Each optical path is configured to apply an optical process that comprises applying optical modulation, by an optical gate of the optical path and under a control of an electrical modulator, to provide an optical signal having a value selected out of multiple constellation levels. The combiner is configured to add the multiple path output signals to provide an oDAC output signal having a value selected from values of a single quadrature constellation.

IPC Classes  ?

• H04B 10/50 - Transmitters
• H04B 10/516 - Details of coding or modulation

Abstract

The present invention provides a pharmaceutical composition including one or more cannabinoids, and methods of using same, such as for treating NOTCH-related diseases.

IPC Classes  ?

• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61K 36/185 - Magnoliopsida (dicotyledons)
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• A61P 9/00 - Drugs for disorders of the cardiovascular system
• A61P 17/06 - Antipsoriatics
• A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
• A61P 19/04 - Drugs for skeletal disorders for non-specific disorders of the connective tissue
• A61P 35/00 - Antineoplastic agents

Abstract

in vivo in vivo functional imaging of the human ear and measurement of nanometer scale motion of the tympanic membrane under various acoustic excitations, and identification of vibration patterns that vary between human subjects in response to sound. By combining spectrally encoded imaging with phase-sensitive spectral-domain interferometry, high-resolution imaging of the membrane surface is obtained within a fraction of a second, through a handheld imaging probe. The detailed physiological data obtained allows measuring a wide range of clinically relevant parameters for patient diagnosis, and provides a new tool for studying middle and inner ear physiology. Use of a line measurement technique, without mechanically scanning the probe beam, enables characteristics of the membrane vibration to be measured, in a time scale of tenths of a second, thereby reducing the possibility of inaccuracy because of movements of the hand-held instrument.

IPC Classes  ?

• A61B 1/227 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor for ears, i.e. otoscopes
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G01B 9/02 - Interferometers
• G01N 21/47 - Scattering, i.e. diffuse reflection

Abstract

An airfoil surface skin, comprising a network of a solid material, embedded in a base of deformable solid material. Fluid pressure applied to the interface between the network and the surrounding embedding material, opens an internal network of channels by viscous peeling of the surrounding solid from the network. The network is offset from the centerline the surround material, such that pressure driven viscous flow through the narrow channels generates two types of deformation of the skin—an in-plane elongation and a curvature of the skin plane itself. The shape of the internal solid core element and its material, and the material of the encompassing solid are chosen to achieve a desired integral structural rigidity. The injected fluid pressure determines the extent of extension and bending. Use of this skin enables shape amending airfoils having reduced drag compared with similar airfoils having conventional flap mechanisms.

IPC Classes  ?

• B64C 3/26 - Construction, shape, or attachment of separate skins, e.g. panels
• B64C 3/48 - Varying camber by relatively-movable parts of wing structures
• B64C 3/44 - Varying camber

Abstract

The invention disclosed herein generally contemplates novel microelectrodes and methods of preparing same.

IPC Classes  ?

• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• C25B 11/02 - ElectrodesManufacture thereof not otherwise provided for characterised by shape or form
• C25B 11/031 - Porous electrodes
• C25B 11/054 - Electrodes comprising electrocatalysts supported on a carrier
• C25B 11/061 - Metal or alloy
• C25B 11/065 - Carbon
• C25B 11/075 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of a single catalytic element or catalytic compound
• C25B 11/077 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of a single catalytic element or catalytic compound the compound being a non-noble metal oxide
• B01J 21/00 - Catalysts comprising the elements, oxides or hydroxides of magnesium, boron, aluminium, carbon, silicon, titanium, zirconium or hafnium

Abstract

The present invention provides a vapor-permeable flexible sensing platform unit comprising: a first porous membrane, wherein said membrane is substantially flexible and hydrophobic; and a volatile organic compounds (VOCs) sensor disposed on said membrane, the VOCs sensor comprising an electrode array and a conducting polymer porous film being in electric contact with said electrode array, wherein the VOCs sensor is insensitive to lateral strain. Further provided are a method of preparation of said platform unit and a lift-off, float-on (LOFO) method for the preparation of protonically doped polyaniline (PANI) thin films.

IPC Classes  ?

• G01N 27/12 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon absorption of a fluidInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon reaction with a fluid
• G01K 7/18 - Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat using resistive elements the element being a linear resistance, e.g. platinum resistance thermometer
• G01L 19/00 - Details of, or accessories for, apparatus for measuring steady or quasi-steady pressure of a fluent medium insofar as such details or accessories are not special to particular types of pressure gauges
• G01N 33/497 - Physical analysis of biological material of gaseous biological material, e.g. breath

Abstract

The invention dislosed herein concerns an amperometric enzyme-based biosensor which exhibits high accuracy, high bioelectrocatalytic currents, linear response, low overpotentials and stability.

IPC Classes  ?

• G01N 27/327 - Biochemical electrodes

Abstract

A method for non-blocking multithreading, the method may include (a) providing, during a deep neural network (DNN) calculation iteration, to a shared computational resource, input information units related to multiple DNN threads; (b) determining whether to reduce a numerical precision of one or more DNN calculations related to at least one of the multiple DNN threads, and (c) executing, based on the determining, DNN calculations on at least some of the input information units to provide one or more results of the DNN processing.

IPC Classes  ?

• G06F 9/52 - Program synchronisationMutual exclusion, e.g. by means of semaphores
• G06N 3/04 - Architecture, e.g. interconnection topology

Abstract

The present invention provides methods and systems for enhanced production and/or secretion of extracellular vesicles (EVs) from muscle cells utilizing various dynamic mechanical loading profiles thereon, cultured on three-dimensional (3D) scaffolds. The scaffolds may comprise a plurality of layers, wherein each layer comprises a plurality of elastic microfibers, and wherein the microfibers are aligned in parallel to a longitudinal axis and to each other. The elastic 3D scaffold may be configured to undergo dynamic mechanical loading profiles and support an expansion of a population of muscle cells cultured thereon into a 3D multi-layer structure of muscle cells, wherein said 3D multi- layer structure is configured to produce and/or secret extracellular vesicles into a medium.

IPC Classes  ?

• C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
• C12M 1/00 - Apparatus for enzymology or microbiology
• C12M 1/42 - Apparatus for the treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic wave
• C12N 5/077 - Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
• A61K 35/34 - MusclesSmooth muscle cellsHeartCardiac stem cellsMyoblastsMyocytesCardiomyocytes

Abstract

The invention provides a system for continuous generation of gases, the system comprising an electrochemical device and an active- material regeneration device.

IPC Classes  ?

• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• C25B 9/21 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof with diaphragms two or more diaphragms
• C25B 9/30 - Cells comprising movable electrodes, e.g. rotary electrodesAssemblies of constructional parts thereof
• C25B 9/60 - Constructional parts of cells
• C25B 9/75 - Assemblies comprising two or more cells of the filter-press type having bipolar electrodes
• C25B 9/77 - Assemblies comprising two or more cells of the filter-press type having diaphragms
• C25B 15/02 - Process control or regulation

Abstract

The invention provides a system for continuous generation of gases, the system comprising an electrochemical device and an active- material regeneration device.

IPC Classes  ?

• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• C25B 9/21 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof with diaphragms two or more diaphragms
• C25B 9/30 - Cells comprising movable electrodes, e.g. rotary electrodesAssemblies of constructional parts thereof
• C25B 9/60 - Constructional parts of cells
• C25B 9/75 - Assemblies comprising two or more cells of the filter-press type having bipolar electrodes
• C25B 9/77 - Assemblies comprising two or more cells of the filter-press type having diaphragms
• C25B 15/02 - Process control or regulation

Abstract

The present disclosure provides mTOR agonists that selectively modulate proteasome dynamics, compositions, methods and uses thereof for modulation of stress-induced proteasome dynamics and related pathological conditions. The present disclosure specifically provides therapeutic methods for treating disorders associated with cytosolic accumulation of the proteasome. The invention further provides prognostic methods for detection and monitoring drug resistant cancers, as well as methods for screening for modulators of proteasome dynamics.

IPC Classes  ?

• A61K 31/198 - Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
• A61P 35/00 - Antineoplastic agents
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

The present disclosure provides mTOR agonists that selectively modulate proteasome dynamics, compositions, methods and uses thereof for modulation of stress-induced proteasome dynamics and related pathological conditions. The present disclosure specifically provides therapeutic methods for treating disorders associated with cytosolic accumulation of the proteasome. The invention further provides prognostic methods for detection and monitoring drug resistant cancers, as well as methods for screening for modulators of proteasome dynamics.

IPC Classes  ?

• A61K 31/198 - Alpha-amino acids, e.g. alanine or edetic acid [EDTA]

Abstract

There may be provided a radiation sensing device that includes a first TMOS with temperature dependent electrical parameters; wherein the first TMOS is exposed to radiation, and a second TMOS transistor that is sheltered from radiation. The radiation sensing device performs a differential measurement, and applied various measures for noise reduction, and maintaining the stability of the radiation sensing device.

IPC Classes  ?

• G01T 1/24 - Measuring radiation intensity with semiconductor detectors

Abstract

The present invention relates to pharmaceutical compositions containing certain phytocannabinoids and their use in treating or preventing headaches, particularly migraine headaches.

IPC Classes  ?

• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61K 36/185 - Magnoliopsida (dicotyledons)
• A61P 25/06 - Antimigraine agents

Abstract

An electro-optic system, the electro-optic system that may include an input port that is configured to receive a bandpass signal that conveys information; wherein the bandpass signal is a radio frequency (RF) signal; an optical carrier source that is configured to generate an optical carrier signal having an optical carrier frequency; at least one electrical bias circuit that is configured to generate at least one electrical bias signal; an electro-optic modulation circuit that is linear at the optical field; a manipulator that is configured to (a) receive the at least one electrical bias signal and the bandpass signal, (b) generate, based on the at least one electrical bias signal and the bandpass signal, at least one modulating signal; wherein the electro-optic modulation circuit is configured to modulate the optical carrier by the at least one modulating signal to provide an output optical signal that comprises at least one optical pilot tone and at least one optical sideband that conveys the information.

IPC Classes  ?

• H04B 10/25 - Arrangements specific to fibre transmission
• H04B 10/2575 - Radio-over-fibre, e.g. radio frequency signal modulated onto an optical carrier
• H04B 10/532 - Polarisation modulation
• G02B 6/293 - Optical coupling means having data bus means, i.e. plural waveguides interconnected and providing an inherently bidirectional system by mixing and splitting signals with wavelength selective means
• G02B 6/28 - Optical coupling means having data bus means, i.e. plural waveguides interconnected and providing an inherently bidirectional system by mixing and splitting signals
• G02B 6/42 - Coupling light guides with opto-electronic elements

Abstract

The present disclosure provides devices, systems, kits and methods for rapid, simple self-sampling and self-performing detection of nucleic acid sequence of interest in a sample, specifically, nucleic acid sequences of pathogenic agents.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• C12Q 1/6865 - Promoter-based amplification, e.g. nucleic acid sequence-based amplification [NASBA], self-sustained sequence replication [3SR] or transcription-based amplification system [TAS]

Abstract

A laser source is presented a plurality of unit cells of a selected number of partially physically coupled lasing units arranged within a plane and configured to form a topological structure, wherein each of the lasing units is configured to emit radiation component substantially perpendicular to said plane, said plurality of the unit cells comprising at least a first sub-array of the unit cells located in a first region interfacing with a second region of a different type than said first region, thereby defining an arrangement of optically coupled lasing units along an interface region between the first and second adjacent regions, forming at least one topological state along a topological path within said interface region.

IPC Classes  ?

• H01S 5/183 - Surface-emitting [SE] lasers, e.g. having both horizontal and vertical cavities having only vertical cavities, e.g. vertical cavity surface-emitting lasers [VCSEL]
• H01S 5/40 - Arrangement of two or more semiconductor lasers, not provided for in groups

Abstract

The present invention relates to methods for selective separation of ionic species from an ionic solution based on said species' ionic hydrated size, the method comprising, inter alia, passing an ionic solution comprising ions having distinct hydrated sizes, through an electrode capacitor assembly comprising at least one carbon-based electrode which is modified with negatively or positively charged surface groups. Further provided is a method for selective separation of ionic species from an ionic solution comprising passing the ionic solution comprising a first positively charged ion and a second positively charged in through an electrode capacitor assembly, wherein the first modified electrode comprises carbon modified with sulfonate surface groups.

IPC Classes  ?

• C02F 1/469 - Treatment of water, waste water, or sewage by electrochemical methods by electrochemical separation, e.g. by electro-osmosis, electrodialysis, electrophoresis
• H01G 11/32 - Carbon-based
• H01G 11/26 - Electrodes characterised by their structure, e.g. multi-layered, porosity or surface features

Abstract

The invention proposes an approach utilizing novel and artificially intelligent hybrid sensor arrays with multiplexed detection capabilities for disease-specific biomarkers from the exhaled breath of a subject. The technology provides a rapid and highly accurate diagnosis in various COVID-19 infection and transmission scenarios.

IPC Classes  ?

• G01N 33/497 - Physical analysis of biological material of gaseous biological material, e.g. breath
• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• A61B 5/083 - Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption

Abstract

A system for extracting water from the atmosphere is disclosed. The system has a vapor absorber vessel, an absorption cycle pump, a flash drum vapor desorber, a vapor condenser, an output conduit, and a heat exchanger. The vessel has an atmospheric air inlet and outlet ports, at least one liquid desiccant inlet port, at least two liquid desiccant outlet ports, and a surface on which the liquid desiccant flows between the at least one liquid desiccant inlet port and the at least two liquid desiccant outlet ports. The pump is adapted to circulate a first portion of the liquid desiccant from a first of the outlet ports to the at least one inlet port. The desorber is adapted to receive a second portion of the liquid desiccant from a second of the outlet ports, after passage through an expansion valve, the desorber incorporates a heat exchanger for supplying heat to liquid desiccant therein. The condenser receives desorbed vapor from the desorber, the condenser incorporates condensation surfaces adapted to be cooled to a temperature of less than 20° C., for enabling the condensing of the desorbed vapor to water. The output conduit collects water condensed in the condenser. The heat exchanger is located such that it receives desorbed heated liquid desiccant from the desorber and transfers part of its sensible heat to vapor-charged liquid desiccant passing from the vessel to the desorber.

IPC Classes  ?

• E03B 3/28 - Methods or installations for obtaining or collecting drinking water or tap water from humid air
• B01D 53/26 - Drying gases or vapours

Abstract

The present invention provides methods of detecting cell-to-cell signaling in cancer cells and methods of diagnosing, prognosing and monitoring cancer comprising the use of volatile organic compounds, which are indicative of cell-to-cell signaling in cancer cells.

IPC Classes  ?

• G01N 33/84 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving inorganic compounds or pH
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• G01N 30/72 - Mass spectrometers

Abstract

A novel structural arrangement for the various components of an Ultra-Micro Gas Turbine Generator, based on a single part impeller element which comprises the compressor, the turbine and the electrical generator core in a single annular structure, produced as a single piece by an additive manufacturing process. The single annular structure has a hollow shell structure, with a supporting structure within in. The internal hollow space of the shell structure provides for a flow of cooling air from the outside through the internal space, for cooling the turbine region of the impeller. This air flow could be assisted by the use of internal blades, which can also serve as the supporting structure to increase the strength of the shell structure. The air flow can either be ejected at the center of the turbine, or can provide a high pressure supply for air bearings of the impeller element.

IPC Classes  ?

• F01D 1/16 - Non-positive-displacement machines or engines, e.g. steam turbines with stationary working-fluid guiding means and bladed or like rotor characterised by having both reaction stages and impulse stages
• F01D 25/16 - Arrangement of bearingsSupporting or mounting bearings in casings
• F01D 25/22 - Lubricating arrangements using working fluid or other gaseous fluid as lubricant
• F02C 7/06 - Arrangement of bearingsLubricating
• H02K 7/18 - Structural association of electric generators with mechanical driving motors, e.g.with turbines

Abstract

The present invention provides a self-healing field-effect transistor (FET) device comprising a self-healing substrate and a self-healing dielectric layer, said substrate and said layer comprising a disulfide-containing poly(urea-urethane) (PUU) polymer, wherein the dielectric layer has a thickness of less than about 10 μm, a gate electrode, at least one source electrode, and at least one drain electrode, said electrodes comprising electrically conductive elongated nanostructures; and at least one channel comprising semi-conducting elongated nanostructures. Further provided is a method for fabricating the FET device.

IPC Classes  ?

• H01L 29/786 - Thin-film transistors
• H01L 29/06 - Semiconductor bodies characterised by the shapes, relative sizes, or dispositions of the semiconductor regions
• H01L 29/16 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only elements of Group IV of the Periodic System in uncombined form
• H01L 29/24 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only inorganic semiconductor materials not provided for in groups , ,  or
• H01L 29/423 - Electrodes characterised by their shape, relative sizes or dispositions not carrying the current to be rectified, amplified or switched
• H01L 29/66 - Types of semiconductor device

Abstract

The present invention provides methods and systems for enhanced production and/or secretion of extracellular vesicles from at least one three-dimensional porous scaffold having a population of stem cells cultured thereon, utilizing various shear stress conditions on a variety of stem cells.

IPC Classes  ?

• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues

Abstract

A molecular data storage system is presented for encoding data-block(s). The system includes one or more populations of molecular sequences, each population encoding a respective one of the data-blocks. Each molecular sequence comprises a data encoding section comprising a sequence of similar predetermined length N of short k-mers, whereby in each population the data encoding sections of all molecular sequences have the similar predetermined length N. The short k-mers serve as data encoding building blocks of the data encoding sections, whereby valid short k-mers serving as data encoding building blocks form a subset of a building-block-set consisting of a number Z of different preselected short k-mers each presenting a unique combination of a number k of bases of a preselected set of bases, characterized in that all the Z types of short k-mers in said building-block-set have a similar predetermined size k≥2 (plurality) of bases. The data encoding sections collectively encode a sequence of encoded alphabet letters S = (π1, π2,..., πn..., πΝ-1, πΝ). Each valid encoded alphabet letter πn at location n of the sequence S of alphabet letters is characterized by occurrence of a predetermined plurality of different types of short k-mers of the building-block-set in a corresponding location n along the data encoding sections of the plurality of molecular sequences of said population.

IPC Classes  ?

• G06N 3/12 - Computing arrangements based on biological models using genetic models
• G16B 30/00 - ICT specially adapted for sequence analysis involving nucleotides or amino acids
• H03M 13/19 - Single error correction without using particular properties of the cyclic codes, e.g. Hamming codes, extended or generalised Hamming codes

Abstract

A data storage system and method are provided, as well as systems and methods for fabrication, and writing and reading of data therein. The data storage system includes at least one population of molecular sequences including chains of basic molecular building-blocks, and defining at least one respective data-block encoding data in the data storage system. The data of the data-block is encoded in a sequence S=(π1, π2, . . . , πk . . . , πK-1, πK) of encoded letters {πk} associated with an alphabet Σ≡{σm}|m=1 to M, which are encoded according to the types of basic molecular building-blocks appearing at k respective location along storage segments of the molecular sequences of the population. The molecular sequences include a number Z of different types of basic molecular building-blocks {En}|n=1 to Z, while the alphabet Σ has a size M strictly greater than the number Z of types of building-blocks. Each alphabet letter σm is associated with a vector {Pmn}|n=1 to Z indicative of occurrences of basic molecular building-block En of type n in the alphabet letter σm. Accordingly each encoded letter πk at location k in the storage segments of molecular sequences of the data-block/population, is mapped to a corresponding alphabet letter σm by determining a match between the occurrence of basic molecular building-blocks of different types at that locations k of the molecular sequences of the population, with the vector {Pmn}|n=1 to Z associated with the alphabet letter σm. In some implementations the component Pmn of the vector {Pmn}m|n=1 to Z associated with alphabet letter σm is indicative of a probability that a basic molecular building-block En of type n, 1≤n≤Z, appears at the location k of the storage segment of a molecular strand of the at least one population in case the letter πk encoded at that location k corresponds to the alphabet letter σm.

IPC Classes  ?

• G06F 3/06 - Digital input from, or digital output to, record carriers

Abstract

The present invention discloses a scintillator structure and to a method for producing an output optical signal at a specific wavelength range. The scintillator structure comprises a multilayer nanostructure formed by at least one pair of alternating first and second layered material being arranged along one or more principal axes. The multi-layer nanostructure defines predetermined geometrical parameters and the structure is made of at least two different material compositions. At least one of the first layered material, the second layered material, or the combination of both, define scintillation properties. The invention also discloses a detector system for detecting an input radiation comprising a scintillator structure being as defined above and being configured and operable to collect most of the emitted optical signal.

IPC Classes  ?

• G01T 1/20 - Measuring radiation intensity with scintillation detectors
• G01T 3/06 - Measuring neutron radiation with scintillation detectors
• G01N 23/00 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or

Abstract

nln2n2 layers of said second layer type generating a selected lattice periodicity of said layers. The lattice periodicity is selected such that said multilayered crystal structure responds to the charged particle beam of predetermined parameters by coherent emission of X-ray radiation having selected spectral content and emission direction.

IPC Classes  ?

• H01J 35/10 - Rotary anodesArrangements for rotating anodesCooling rotary anodes
• H01J 35/08 - AnodesAnticathodes
• G01N 23/04 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by transmitting the radiation through the material and forming images of the material

Abstract

The invention provides a method for treating cancer in which a level of reduced folate carrier (RFC) or folylpolyglutamate synthetase (FPGS) in cancer cells of the biopsy is determined. If the level of RFC or FPGS in the cancer cells is below a threshold value, the cancer is treated with an inhibitor of serine-hydroxymethyl-transferase (SHMT)1. If the level of RFC or FPGS in the cancer cells is above the threshold value, the cancer is treated with an inhibitor of SHMT2.

IPC Classes  ?

• A61K 31/4162 - 1,2-Diazoles condensed with heterocyclic ring systems
• A61P 35/00 - Antineoplastic agents
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer

Abstract

The present invention provides pharmaceutical compositions comprising membrane vesicles, including extracellular vesicles including those referred to as exosomes, loaded with an exogenous Phosphatase and tensin homolog (PTEN) inhibitor. Methods of treating neurological diseases, disorders or conditions using the extracellular vesicles are provided. Isolated extracellular vesicles loaded with an exogenous Phosphatase and tensin homolog (PTEN) inhibitor are provided as well.

IPC Classes  ?

• C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
• C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61K 35/28 - Bone marrowHaematopoietic stem cellsMesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• A61K 38/51 - Lyases (4)
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 9/50 - Microcapsules
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant

Abstract

A high-efficiency, motorless purge system for closed-cycle absorption heat pumps, adapted for both absorption heat transformers and absorption chillers, using a series of valves to control the entry and exit of absorbent solution into a low-pressure, secondary absorption vessel. A small percentage of the total circulating solution is forced under pressure into the secondary absorption vessel via a spray nozzle, causing adiabatic absorption of absorbate vapor by the solution. Non-condensable gases accumulate in the secondary absorber until a certain vapor pressure is reached, upon which, gas, and possibly liquid, are transferred to an exhaust vessel having an exit vent for non-condensable gases. In an absorption chiller system, the secondary absorber has an internal heat exchanger to lower the temperature of the solution within, to facilitate the absorption process.

IPC Classes  ?

• F25B 43/04 - Arrangements for separating or purifying gases or liquidsArrangements for vaporising the residuum of liquid refrigerant, e.g. by heat for withdrawing non-condensible gases
• F25B 15/06 - Sorption machines, plants or systems, operating continuously, e.g. absorption type without inert gas the refrigerant being water vapour evaporated from a salt solution, e.g. lithium bromide
• F25B 30/04 - Heat pumps of the sorption type

Abstract

Provided are electrochemical cells and methods for generating hydrogen gas and oxygen gas.

IPC Classes  ?

• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• C25B 9/70 - Assemblies comprising two or more cells
• C25B 15/02 - Process control or regulation

Abstract

A thermochemical recuperation (TCR) system that may use a water-alcohol mixture as an engine liquid coolant; that may include a TCR reformer configured to output a TCR product at pressure no less than twenty bars; a pressure regulator; and an TCR product accumulator configured to separate an outputting of the TCR product by the TCR reformer from a provision of the TCR product to the pressure regulator; wherein the pressure regulator is configured to provide the TCR product to a direct injector of an engine, thereby enabling the direct injector to inject the TCR product at a high pressure level – for example at a pressure level that exceeds twenty bars.

IPC Classes  ?

• F01N 5/02 - Exhaust or silencing apparatus combined or associated with devices profiting by exhaust energy the devices using heat
• F02G 5/04 - Profiting from waste heat of exhaust gases in combination with other waste heat from combustion engines
• F02M 25/12 - Engine-pertinent apparatus for adding non-fuel substances or small quantities of secondary fuel to combustion-air, main fuel or fuel-air mixture adding acetylene, non-waterborne hydrogen, non-airborne oxygen, or ozone the apparatus having means for generating such gases
• F02M 27/02 - Apparatus for treating combustion-air, fuel, or fuel-air mixture, by catalysts, electric means, magnetism, rays, sonic waves, or the like by catalysts

Abstract

A device having a nano-wire array and a method for manufacturing an array of nano-wires. The method includes spraying on a substrate droplets of a suspension that comprises nano-wires and at least a partially volatile solvent; and evaporating the at least partially volatile solvent of the droplets to form the array of nano-wires. At least one of the spraying and the evaporating comprises executing at least one aggregation reduction measure for limiting a formation of three dimensional aggregations of nano-wires on the substrate.

IPC Classes  ?

• H01L 21/00 - Processes or apparatus specially adapted for the manufacture or treatment of semiconductor or solid-state devices, or of parts thereof
• H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
• B82Y 40/00 - Manufacture or treatment of nanostructures
• H01L 29/786 - Thin-film transistors

Abstract

The present invention provides methods and systems for enhanced production and/or secretion of extracellular vesicles from at least one three-dimensional porous scaffold having a population of stem cells cultured thereon, utilizing various shear stress conditions on a variety of stem cells.

IPC Classes  ?

• C12N 5/0775 - Mesenchymal stem cellsAdipose-tissue derived stem cells
• A61K 35/28 - Bone marrowHaematopoietic stem cellsMesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
• C12M 1/18 - Multiple fields or compartments

Abstract

A system and method for determining the condition of a thermal barrier coating on a base metal component, comprising the use of an induction coil to input into the metallic base layer through the coating layer, a temporally varying heat waveform, and measuring the temperature of the coating surface layer resulting from the input of the heat waveform using a temperature sensor disposed close to the surface of the coating layer. A controller correlates a signal from the temporally varying output of the temperature sensor with a signal corresponding to the temporally varying heat waveform, to determine the phase angle between the signals. The controller uses a mathematical relationship between the phase angle and the frequency of the heat waveform to determine the thermal properties of the non- metallic coating. Both the thermal diffusivity and the barrier coating thickness can be accurately obtained by this method and apparatus.

IPC Classes  ?

• F01D 5/28 - Selecting particular materialsMeasures against erosion or corrosion
• F01D 5/08 - Heating, heat-insulating, or cooling means
• G01J 5/00 - Radiation pyrometry, e.g. infrared or optical thermometry
• H05B 6/02 - Induction heating
• G01N 25/72 - Investigating presence of flaws

Abstract

A method for sensing gas by a gas sensing device, the method may include generating, by a semiconductor temperature sensing element that is spaced apart from a gas reactive element and is thermally coupled to the gas reactive element, detection signals that are indicative of a temperature of the gas reactive element; wherein the gas reactive element and the semiconductor temperature sensing element are of microscopic scale; and processing, by a readout circuit of the gas sensing device, the detection signals to provide information about a gas that affected the temperature of the gas reactive element.

IPC Classes  ?

• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
• G01N 25/30 - Investigating or analysing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity on combustion or catalytic oxidation, e.g. of components of gas mixtures the rise in temperature of the gases resulting from combustion being measured directly using electric temperature-responsive elements

Abstract

A robotic shoe which provides real-time feedback regarding forces acting on the foot of the user, in order to modify these forces in a corrective or diagnostic manner. The shoe comprises an insole equipped with embedded pressure sensors enabling it to continuously monitor the ground reaction forces (GRF) and the foot center of pressure (COP) while the user is standing, walking, and running. The insole COP and GRF readings are input to a programmable system that shifts the COP trajectory dynamically in a patient-specific manner via the robotic platform of the shoe. The robotic platform contains motors that control elements whose movement manipulates the forces acting on the foot and lower limb, resulting in modification of the GRF. Closed loop feedback enables a dynamic fit of an optimal COP. The COP and GRF information can be stored for analysis and diagnosis of gait and instability events accruing during locomotion.

IPC Classes  ?

• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
• A43B 17/00 - Insoles for insertion, e.g. footbeds or inlays, for attachment to the shoe after the upper has been joined
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

1 11205144567892223 31205144 912051414)aryl; m is 4; wherein the elastomer is dynamically crosslinked by aromatic disulfide metathesis, and wherein the elastomer has a water contact angle of above 100⁰.

IPC Classes  ?

• C08L 75/08 - Polyurethanes from polyethers
• C09D 175/08 - Polyurethanes from polyethers
• C09D 175/04 - Polyurethanes
• C09J 175/02 - Polyureas
• C09J 175/04 - Polyurethanes
• C08K 3/08 - Metals
• C08G 18/10 - Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
• C08G 18/32 - Polyhydroxy compoundsPolyaminesHydroxy amines
• C08G 18/48 - Polyethers
• C08G 18/65 - Low-molecular-weight compounds having active hydrogen with high-molecular-weight compounds having active hydrogen
• C08G 18/75 - Polyisocyanates or polyisothiocyanates cyclic cycloaliphatic
• G01N 27/00 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
• G01N 27/12 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon absorption of a fluidInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon reaction with a fluid
• B82Y 15/00 - Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors

Abstract

A method for detecting or monitoring the respiratory or cardiac health of a patient, including: measuring any intravascular or intracardiac pressure (IVP) of a patient over a period of time, said IVP including a measured respiratory wave; defining the respiratory effort of the patient as a peak-to-peak amplitude of the respiratory wave; and using the respiratory effort to detect or monitor the respiratory and cardiac health of the patient by comparing the respiratory effort with a known respiratory effort value or by monitoring changes in the respiratory effort of the patient over another period of time.

IPC Classes  ?

• A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition

Abstract

There is provided a gas sensing device for sensing a certain gas that is associated with a certain spectral band, the gas sensing device may include a passive gas sensor that is configured to generate passive gas sensor detection signals that are responsive to the certain spectral band; a passive dummy sensor that is configured to generate passive dummy sensor detection signals that are indifferent to the certain spectral hand; and at least one circuit that is configured to detect a presence or absence of the certain gas within a certain volume that is located within the fields of view of the passive gas sensor and the passive dummy sensor based on a comparison between the passive gas sensor detection signals and the passive dummy sensor detection signals.

IPC Classes  ?

• G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups

Abstract

The present invention provides a vapor-permeable flexible sensing platform unit comprising: a first porous membrane, wherein said membrane is substantially flexible and hydrophobic; and a volatile organic compounds (VOCs) sensor disposed on said membrane, the VOCs sensor comprising an electrode array and a conducting polymer porous film being in electric contact with said electrode array, wherein the VOCs sensor is insensitive to lateral strain. Further provided are a method of preparation of said platform unit and a lift-off, float-on (LOFO) method for the preparation of protonically doped polyaniline (PANI) thin films.

IPC Classes  ?

• G01N 33/497 - Physical analysis of biological material of gaseous biological material, e.g. breath
• G01K 7/18 - Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat using resistive elements the element being a linear resistance, e.g. platinum resistance thermometer
• G01L 19/00 - Details of, or accessories for, apparatus for measuring steady or quasi-steady pressure of a fluent medium insofar as such details or accessories are not special to particular types of pressure gauges

Abstract

An airfoil surface skin, comprising a network of a solid material, embedded in a base of deformable solid material. Fluid pressure applied to the interface between the network and the surrounding embedding material, opens an internal network of channels by viscous peeling of the surrounding solid from the network. The network is offset from the centerline the surround material, such that pressure driven viscous flow through the narrow channels generates two types of deformation of the skin - an in-plane elongation and a curvature of the skin plane itself. The shape of the internal solid core element and its material, and the material of the encompassing solid are chosen to achieve a desired integral structural rigidity. The injected fluid pressure determines the extent of extension and bending. Use of this skin enables shape amending airfoils having reduced drag compared with similar airfoils having conventional flap mechanisms.

IPC Classes  ?

• B64C 3/00 - Wings
• B64C 3/44 - Varying camber

Abstract

A ptychography system is presented for imaging an object located in an object plane. The ptychography system comprises an optical system, and a detection device. The optical system comprises a single shot ptychography arrangement configured and operable to create light response patterns from the object in the object plane on a pixel matrix of the detection device during the same exposure session of the detection device, wherein the optical system further comprises at least one light coding device configured and operable to apply at least one predetermined coding function to at least one of illuminating light and the light response of the object being collected, and said detection device is configured and operable with a predetermined duration of the exposure session during which the pixel matrix detects the collected light, such that image data indicative of the detected light during a single exposure session is in the form of a coded light response of the object being illuminated.

IPC Classes  ?

• H04N 9/47 - Colour synchronisation for sequential signals
• G02B 21/36 - Microscopes arranged for photographic purposes or projection purposes
• G02B 21/00 - Microscopes

Abstract

A topological laser system is described. The laser system comprises an array of optical elements arranged in an array and coupled between them such that the array is configured for supporting one or more topological modes. The plurality of optical elements comprises optical elements carrying gain material configured for emitting optical radiation in response to pumping energy. The laser system further comprises a pumping unit configured to provide pumping of a group of the optical elements of the array within at least a portion of the spatial region corresponding with said topological mode; and at least one output port optically coupled to one or more of the optical elements associated with said topological mode. The at least one output ports is configured for extracting a portion of light intensity from said laser system.

IPC Classes  ?

• H01S 5/40 - Arrangement of two or more semiconductor lasers, not provided for in groups
• G02B 6/122 - Basic optical elements, e.g. light-guiding paths
• H01S 5/04 - Processes or apparatus for excitation, e.g. pumping
• H01S 5/10 - Construction or shape of the optical resonator
• H01S 5/11 - Comprising a photonic bandgap structure
• H01S 5/343 - Structure or shape of the active regionMaterials used for the active region comprising quantum well or superlattice structures, e.g. single quantum well [SQW] lasers, multiple quantum well [MQW] lasers or graded index separate confinement heterostructure [GRINSCH] lasers in AIIIBV compounds, e.g. AlGaAs-laser
• H01S 5/02251 - Out-coupling of light using optical fibres

Abstract

A gas sensing device, comprising a bulk and an array of gas sensing elements that are thermally isolated from the bulk, wherein each gas sensing element of a plurality of gas sensing elements of the array comprises (i) a gas reactive element that has a gas dependent temperature parameter; (ii) a semiconductor temperature sensing element that is thermally coupled to the gas reactive element and is configured to generate detection signals that are responsive to a temperature of the gas reactive element; and (iii) multiple heating elements that are configured to heat the gas reactive element to at least one predefined temperature.

IPC Classes  ?

• G01N 27/16 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of an electrically-heated body in dependence upon change of temperature caused by burning or catalytic oxidation of surrounding material to be tested, e.g. of gas
• G01N 25/20 - Investigating or analysing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity
• G01N 25/30 - Investigating or analysing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity on combustion or catalytic oxidation, e.g. of components of gas mixtures the rise in temperature of the gases resulting from combustion being measured directly using electric temperature-responsive elements
• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
• G01K 7/01 - Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat using semiconducting elements having PN junctions
• H01L 21/764 - Air gaps

Abstract

Highly efficient digital domain sub-band based receivers and transmitters.

IPC Classes  ?

• H04L 25/03 - Shaping networks in transmitter or receiver, e.g. adaptive shaping networks
• H03H 11/52 - One-port networks simulating negative resistances
• H04B 17/364 - Delay profiles
• H03H 21/00 - Adaptive networks
• H03H 17/02 - Frequency-selective networks
• H04L 27/26 - Systems using multi-frequency codes
• H04L 25/02 - Baseband systems Details
• H04B 7/005 - Control of transmissionEqualising
• H04B 7/0452 - Multi-user MIMO systems
• H04B 7/0413 - MIMO systems

Abstract

The invention relates to an activating composition comprising a cell, which may be any cell type used for cell therapy, wherein the cell is activated by a chemotherapy agent. Further, there is provided an activating composition comprising a supernatant of a composition comprising a cell, which may be any cell type used for cell therapy, wherein the cell is activated by a chemotherapy agent and wherein the supernatant is used as a therapy. The invention further provides methods for treating or preventing a disease or a condition comprising the use of the activated composition.

IPC Classes  ?

• A61K 35/14 - BloodArtificial blood
• A61K 35/16 - Blood plasmaBlood serum

Abstract

The invention relates to an activating composition comprising a cell, which may be any cell type used for cell therapy, wherein the cell is activated by a chemotherapy agent. Further, there is provided an activating composition comprising a supernatant of a composition comprising a cell, which may be any cell type used for cell therapy, wherein the cell is activated by a chemotherapy agent and wherein the supernatant is used as a therapy. The invention further provides methods for treating or preventing a disease or a condition comprising the use of the activated composition.

IPC Classes  ?

• A61K 35/14 - BloodArtificial blood
• A61K 35/16 - Blood plasmaBlood serum

Abstract

inter alia inter alia, passing an ionic solution comprising ions having distinct hydrated sizes, through an electrode capacitor assembly comprising at least one carbon-based electrode which is modified with negatively or positively charged surface groups. Further provided is a method for selective separation of ionic species from an ionic solution comprising passing the ionic solution comprising a first positively charged ion and a second positively charged in through an electrode capacitor assembly, wherein the first modified electrode comprises carbon modified with sulfonate surface groups.

IPC Classes  ?

• C02F 1/469 - Treatment of water, waste water, or sewage by electrochemical methods by electrochemical separation, e.g. by electro-osmosis, electrodialysis, electrophoresis
• H01G 11/30 - Electrodes characterised by their material
• C02F 103/08 - Seawater, e.g. for desalination

Abstract

The present invention provides a self-healing field-effect transistor (FET) device comprising a self-healing substrate and a self-healing dielectric layer, said substrate and said layer comprising a disulfide-containing poly(urea-urethane) (PUU) polymer, wherein the dielectric layer has a thickness of less than about 10 µm, a gate electrode, at least one source electrode, and at least one drain electrode, said electrodes comprising electrically conductive elongated nanostructures; and at least one channel comprising semi-conducting elongated nanostructures. Further provided is a method for fabricating the FET device.

IPC Classes  ?

• G01N 27/12 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon absorption of a fluidInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon reaction with a fluid
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites

Abstract

Embodiments of the invention are directed to a method of separating and encapsulating an analyte on a microfluidic device in order to extract the analyte. A microfluidic device is provided having a main microchannel and a set of one or more auxiliary microchannels, each branching to the main microchannel at respective junctions therewith. A mixture is introduced as a single phase in the main microchannel in order to electrokinetically separate an analyte from the introduced mixture, and in order to confine the separated analyte in a microchannel portion of the main microchannel. The microchannel portion adjoins one of the junctions. One or more encapsulating volumes of an encapsulating phase are injected in the main microchannel via one or more of the auxiliary microchannels. The encapsulating phase is immiscible with said single phase. The encapsulated analyte is extracted from the main microchannel via one or more of the auxiliary microchannels.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• G01N 27/447 - Systems using electrophoresis
• C07K 1/28 - Isoelectric focusing