Provided herein are nanoengineered biomaterial inks used to 3D print a biocompatible, flexible electronic device, for example, a hydrogel constructs a biocompatible, flexible electronic device or 3D printed wearable electronic devices. The biocompatible, flexible electronic device may be a crosslinked gelatin-SH-2D-MoS2 nanoassembly. Also provided are methods for nanoengineering a biomaterial ink and for determining a treatment for a subject in need thereof utilizing the biocompatible, flexible electronic device.
B01J 13/00 - Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided forMaking microcapsules or microballoons
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
An example method of predicting a phenotype of interest of a subject includes generating apluralityofbiomarkers; selectingasubsetofbiomarkersfromthepluralityofbiomarkers;anddeterminin garelationshipbetweenthesubsetofbiomarkersandthephenotypeofinterest;receivingsample biomarkers;where thesample biomarkerscomprise oneor more measurementsofthesubject;andpredictingthephenotypeofinterestofthesubjectbasedonthesampleb iomarkers and the relationship between the subsetof biomarkers and the phenotype of interest.
A bioreactor device may include a housing assembly having a body defining a bioreactor cavity with an opening, a lid to be received by the opening and including rack openings, and a port coupled to the bioreactor cavity. The bioreactor device may also include racks respectively received by the rack openings. Each of the racks may include a vertical arm, vertically spaced supports coupled to the vertical arm, and substrates respectively carried by the vertically spaced supports, each substrate having culture media thereon. The bioreactor device may also include a control unit coupled to the port and configured to selectively supply culture medium to the bioreactor cavity based upon a characteristic within the bioreactor cavity.
The present disclosure provides compositions and methods for increasing mitochondrial function or decreasing cellular oxidative stress. The present disclosure further provides nanomaterial structures comprising high atomic vacancy concentrations. Aspects of the disclosure further relate to methods for treating diseases or disorders associated with decreased mitochondrial function or increased cellular oxidative stress.
A61K 33/00 - Medicinal preparations containing inorganic active ingredients
A61K 33/04 - Sulfur, selenium or telluriumCompounds thereof
A61K 47/52 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an inorganic compound, e.g. an inorganic ion that is complexed with the active ingredient
An example system for predicting a phenotypic measurement includes a remote sensing platform comprising a remote sensor configured to capture image data, where the image data comprises a plurality of temporally-spaced images of a plant; and a computing device operably coupled to the remote sensing platform, where the computing device includes at least one processor and memory, the memory having computer-executable instructions stored thereon that, when executed by the at least one processor, cause the at least one processor to: input the image data into a prediction model; and determine, using the prediction model, a phenotypic measurement.
An instrumented blanket includes an insulative material and a temperature control structure integrated with the insulative material. The heating structure is configured to produce a heat or a cooling output in response to an input signal. The temperature-control blanket further includes an optical sensor including an optical fiber integrated with the insulative material along the heating structure. The optical sensor is configured to detect a change in an optical property measured from a plurality of intervals along a length of the optical fiber. The change in the optical property is indicative of a temperature of the temperature-control blanket at a respective interval of the plurality of intervals.
G01K 11/3206 - Measuring temperature based on physical or chemical changes not covered by group , , , or using changes in transmittance, scattering or luminescence in optical fibres at discrete locations in the fibre, e.g. using Bragg scattering
G01K 7/02 - Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat using thermoelectric elements, e.g. thermocouples
7.
SYSTEMS AND METHODS FOR DETECTING AND PREDICTING PHENOTYPIC MEASUREMENTS AND PHENOTYPES
An example system for predicting a phenotypic measurement includes a remote sensing platform comprising a remote sensor configured to capture image data, where the image data comprises a plurality of temporally-spaced images of a plant; and a computing device operably coupled to the remote sensing platform, where the computing device includes at least one processor and memory, the memory having computer-executable instructions stored thereon that, when executed by the at least one processor, cause the at least one processor to: input the image data into a prediction model; and determine, using the prediction model, a phenotypic measurement.
G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
An example method of predicting a phenotype of interest of a subject includes generating a plurality of biomarkers; selecting a subset of biomarkers from the plurality of biomarkers; and determining a relationship between the subset of biomarkers and the phenotype of interest; receiving sample biomarkers; where the sample biomarkers comprise one or more measurements of the subject; and predicting the phenotype of interest of the subject based on the sample biomarkers and the relationship between the subset of biomarkers and the phenotype of interest.
G16B 5/00 - ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
G16B 25/10 - Gene or protein expression profilingExpression-ratio estimation or normalisation
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
9.
ELECTROCHEMICAL STORAGE INCORPORATING SIZE- AND MORPHOLOGY-CONTROLLED METASTABLE VANADIUM PENTOXIDE AS A CATHODE MATERIAL FOR ION BATTERIES
The Li-ion paradigm of battery technology is fundamentally constrained by the monovalency of the Li-ion. A straightforward solution is to transition to multivalent ion chemistries, with Mg2+ the most obvious candidate due to considerations of size and mass. Despite early interest, the realization of Mg batteries has faced myriad obstacles, including a sparse selection of cathode materials demonstrating the ability to reversibly insert divalent ions. Disclosed herein is evidence of reversible topochemical and electrochemical insertion of Mg2+ into a metastable one-dimensional polymorph of V2O5. Not only does ζ-V2O5 represent a rare addition to the pantheon of functional Mg battery cathode materials, but is also distinctive in exhibiting a combination of high stability, high specific capacity due to ion insertion, and moderately high operating voltage.
In an embodiment. the present disclosure pertains to environmental biospecimen recovery after in-droplet gel encapsulation (eBRIDGE) platforms for co-culturing multiple microorganisms in gel microspheres and then transferring single-cell-derived clonal populations from within the gel microspheres into separate water-in-oil emulsion droplets for further processing and analysis. In some embodiments. the gel-encapsulated bacteria are released by lysing the gel matrix using an enzyme. The methods of the present disclosure provide a single workflow that goes from environmental microbial harvesting and amplification to functional interrogation of their characteristics.
A wearable biosensor for real-time quantification of a biomarker in a biofluid includes at least one functional module. The functional module includes an iontophoresis induction module, a microfluidic layer, a plurality of multimodal biosensors, and a paperfluidic layer.
A61B 5/1477 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means non-invasive
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
12.
SMART SINGLE-DOMAIN INTRABODIES WITH PRECISION SWITCHES FOR BIOMEDICAL APPLICATIONS
The present disclosure provides intrabody compositions comprising i) an intrabody and ii) one or more inserts. The disclosure also provides methods for activating and deactivating intracellular and extracellular interactions utilizing the compositions, for instance via chemical and/or light.
C07K 14/71 - ReceptorsCell surface antigensCell surface determinants for growth factorsReceptorsCell surface antigensCell surface determinants for growth regulators
A61K 47/65 - Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
13.
PHYSIOLOGICALLY RELEVANT PUMPS AND ASSOCIATED SYSTEMS AND METHODS
A physiologically relevant pump includes a support frame, a flexible bladder sealingly coupled to the support frame, a mechanical drive coupled to at least one of the support frame, and a pump motor coupled to the support frame and the mechanical drive and configured, in response to receiving a control signal, to displace, through the mechanical drive, a first end of the flexible bladder relative to a second end of the flexible bladder to alter an internal volume of the flexible bladder whereby a desired fluid pressure in an internal chamber of the flexible bladder is achieved.
G05D 7/06 - Control of flow characterised by the use of electric means
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
A61B 6/58 - Testing, adjusting or calibrating thereof
14.
CYNOBACTERIA CULTIVATION, SEDIMENTATION, AND UTILIZATION
The present invention is related to the fields of bioplastics. In particular, a strain of photosynthetic cyanobacteria (i.e. blue-green algae) having a high growth rate was engineered to overexpress limonene synthase. These engineered cyanobacteria improve auto-sedimentation for biomass harvest and provide for plastic bioremediation capture. Further, machine-learning methods are provided for improving some of the aspects of cultivating cyanobacteria including, but not limited to, assessing real-time light availability and predicting real-time algae growth rates to increase a cyanobacteria biomass.
In an embodiment, the present disclosure pertains to a method of deposition of nanostructures with engineered patterns. In an additional embodiment, the present disclosure pertains to a method of preparing colloidal suspensions of hybrid nanoparticle systems (HNMS). In a further embodiment, the present disclosure pertains to a method of making a cellulose nanocrystal (CNC)-bonded carbon nanotube carbon fiber reinforced polymer (CNT-CFRP) hybrid composite. In another embodiment, the present disclosure pertains to a method of making a cellulose nanocrystal (CNC)-bonded graphene nanoplatelets (GNP) carbon fiber reinforced polymer (GNP-CFRP) hybrid composite. In a further embodiment, the present disclosure pertains to a method of making a hybrid cellulose nanocrystal (CNC)-graphene nanoplatelet(boron nitride nanobarb) (GNP-(BNNB))-carbon fiber (CF)Zpolyether ether ketone (PEEK) using spray-coating.
A wearable biosensing system includes a case, a contact carriage, a biosensor, and a contact pressure management unit. The case is adapted to be fixed to a skin surface of a user. The contact carriage is mounted for movement relative to the case into contact with the skin surface of the user to apply a contact pressure to the skin surface of the user. The biosensor is configured to measure physiological signals of the user. The contact pressure management includes at least one pressure sensor configured to output pressure data.
A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
A61B 5/0295 - Measuring blood flow using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
41 - Education, entertainment, sporting and cultural services
Goods & Services
41 - Educational services, namely, providing courses of instruction at the college level; entertainment services, namely, organizing and conducting college sports events, lectures, college graduation ceremonies; providing news and information in the field of sports and academics; providing a website featuring blogs and non-downloadable publications in the nature of articles and information in the fields of academics, alumni achievements, athletics, research, service, and student life
41 - Education, entertainment, sporting and cultural services
Goods & Services
41 - Educational services, namely, providing courses of instruction at the college level; entertainment services, namely, organizing and conducting college sports events, lectures, college graduation ceremonies; providing news and information in the field of sports and academics; providing a website featuring blogs and non-downloadable publications in the nature of articles and information in the fields of academics, alumni achievements, athletics, research, service, and student life
19.
CEASELESS INDUSTRY FEARLESS INVESTIGATION UNFETTERED THOUGHT UNSELFISH SERVICE EAST TEXAS A&M UNIVERSITY 1889
41 - Education, entertainment, sporting and cultural services
Goods & Services
Educational services, namely, providing courses of instruction at the college level; entertainment services, namely, organizing and conducting college graduation ceremonies.
41 - Education, entertainment, sporting and cultural services
Goods & Services
41 - Educational services, namely, providing courses of instruction at the college level; entertainment services, namely, organizing and conducting college sports events, lectures, college graduation ceremonies; providing news and information in the field of sports and academics; providing a website featuring blogs and non-downloadable publications in the nature of articles and information in the fields of academics, alumni achievements, athletics, research, service, and student life
41 - Education, entertainment, sporting and cultural services
Goods & Services
Educational services, namely, providing courses of instruction at the college level; entertainment services, namely, organizing and conducting college sports events, lectures, college graduation ceremonies; providing news and information in the field of sports and academics; providing a website featuring blogs and non-downloadable publications in the nature of articles and information in the fields of academics, alumni achievements, athletics, research, service, and student life.
41 - Education, entertainment, sporting and cultural services
Goods & Services
Educational services, namely, providing courses of instruction at the college level; entertainment services, namely, organizing and conducting college sports events, lectures, college graduation ceremonies; providing news and information in the field of sports and academics; providing a website featuring blogs and non-downloadable publications in the nature of articles and information in the fields of academics, alumni achievements, athletics, research, service, and student life
41 - Education, entertainment, sporting and cultural services
Goods & Services
41 - Educational services, namely, providing courses of instruction at the college level; entertainment services, namely, organizing and conducting lectures; providing news and information in the field of academics
41 - Education, entertainment, sporting and cultural services
Goods & Services
Educational services, namely, providing courses of instruction at the college level; entertainment services, namely, organizing and conducting college sports events, lectures, college graduation ceremonies; providing news and information in the field of sports and academics; providing a website featuring blogs and non-downloadable publications in the nature of articles and information in the fields of academics, alumni achievements, athletics, research, service, and student life.
41 - Education, entertainment, sporting and cultural services
Goods & Services
Educational services, namely, providing courses of instruction at the college level; entertainment services, namely, organizing and conducting college sports events, lectures, college graduation ceremonies; providing news and information in the field of sports and academics; providing a website featuring blogs and non-downloadable publications in the nature of articles and information in the fields of academics, alumni achievements, athletics, research, service, and student life.
26.
SYNTHETIC PROTEIN SCAFFOLDS TO TARGET AND REMOVE BACTERIAL VIRULENCE PILI
Synthetic bacterial phage maturation (Mat) protein scaffolds, compositions, and methods of use to decrease bacterial virulence, treat and prevent bacterial infections, and lower the incidence of bacterial gene transfers to combat the spread of treatment-resistant bacterial strains. Scaffolds include at least a portion of an apical domain of a Mat protein and can decrease type IV pili (T4P) attachment for reduction of bacterial virulence.
An apparatus for surgical lighting is disclosed. The apparatus includes a light emitting element formed with a light source encapsulated within an outer layer. The outer layer includes a biocompatible material. A power supply is coupled to the light source. The apparatus includes an actuating mechanism that controls power from the power supply to the light source to emit light along a surgical area. The light emitting element provides enhanced illumination and other surgical advantages.
A61B 90/30 - Devices for illuminating a surgical field, the devices having an interrelation with other surgical devices or with a surgical procedure
A61B 17/00 - Surgical instruments, devices or methods
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
F21S 2/00 - Systems of lighting devices, not provided for in main groups or , e.g. of modular construction
A passive infrared (PIR) sensor system, includes a PIR sensor configured to produce an output signal in response to receiving infrared (IR) radiation, an electronic shutter positionable in a field of view (FOV) of the PIR sensor, wherein the electronic shutter includes a liquid crystal (LC) material, wherein the electronic shutter includes a first state providing a first transmissivity of IR radiation through the electronic shutter and a second state providing a second transmissivity of IR radiation through the electronic shutter that is less than the first transmissivity, and a shutter actuator configured to apply an actuation signal to the electronic shutter to actuate the electronic shutter between the first state and the second state.
G01J 5/0875 - WindowsArrangements for fastening thereof
G01J 5/34 - Radiation pyrometry, e.g. infrared or optical thermometry using electric radiation detectors using capacitors, e.g. pyroelectric capacitors
Described herein are compounds and methods for the treatment of coronavirus infection. The compounds can function as an inhibitor of the main protease (Mpro) of coronaviruses. The compounds can include diphenylmethyl piperazine derivatives, diphenylmethyl piperidine derivatives, diphenylmethylidene piperidine derivatives, tricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen derivatives, tricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,9,12,14-heptaen derivatives, 6,11-dihydrobenzo[c][1]benzoxepin derivatives, 6,11-dihydrobenzo[c][1]benzothiepin derivatives, 5,5-dioxo-6,11-dihydrobenzo[c][1]benzothiepin derivatives, and 6-oxo-5,11-dihydrobenzo[c][1]benzazepin derivatives, as well as pharmaceutically acceptable salts, hydrates, and prodrugs thereof.
A61K 31/444 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
A61K 31/4545 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
A61K 31/4995 - Pyrazines or piperazines forming part of bridged ring systems
A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
C07D 409/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 409/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
The current disclosure provides polypeptides and peptides comprising SEQ ID NO: 1. Antibodies or antigen binding fragments thereof specifically bind to a polypeptide comprising SEQ ID NO: 1 or peptide fragments thereof (e.g., SEQ ID NOs: 2 and/or 3) are also provided. Accordingly, the current disclosure provides polypeptides and peptides comprising ant one of SEQ ID NOs: 1-6 or fragments thereof. The antibodies or antigen binding fragments thereof can be monoclonal antibodies (Mab), chimeric antibodies, single chain antibodies, single chain fragment variable (scFv) antibodies, or fragment antigen-binding (Fab fragment). The antibodies or antigen binding fragments thereof can be labeled with an enzyme, a radioisotope, a fluorescent label, or a bioluminescent label and/or used in diagnostic assays. Diagnostic assays and vaccines using the disclosed polypeptides or fragments thereof are also provided.
Provided are compositions and methods for modifying a plant genome. Methods and compositions are also provided for delivering genome editing components across graft junctions and generating genome modified plants in the presence of a selection agent without integration of a selectable marker gene into the genome. Recombinant DNA constructs for modifying a plant genome and plants comprising the same are further provided.
Toyota Motor Engineering & Manufacturing North America, Inc. (USA)
Toyota Jidosha Kabushiki Kaisha (Japan)
The Texas A&M University System (USA)
Inventor
Ponce Valderrama, Victor
Marjuban, Shaik Merkatur Hakim
Castaneda-Lopez, Homero
Eich, Heather M.
Tarr, Walter D.
Abstract
A corrosion monitoring system includes a processor, and a memory in communication with the processor and having a control module, a potentiostat, coupled to a clamp with a first plate and a second plate. The control module includes instructions that, when executed by the processor, cause the processor to control the potentiostat to apply a voltage to the first plate and the second plate during an EIS test of a coating on a metal substrate disposed between the first plate and the second plate. The corrosion monitoring system also monitors or detects a change in at least one of a phase angle and an impedance of the applied voltage, and identifies a change in corrosion activation at the substrate for any coating system based, at least in part, on the change in the at least one of the phase angle and the impedance.
A system for identifying one or more substances in a liquid sample using micro¬ plasma induced breakdown spectroscopy (MIBS) includes a system controller including a processor and memory encoded with instructions that, when executed by the processor, cause the processer to activate one or more pulse generators to apply one or more electrical pulses to a plasma electrode whereby a plasma discharge is generated in the liquid sample when the liquid sample is received in the plasma receptacle, wherein the voltage of each of the one or more electrical pulses applied to the plasma electrode is between 13 kilovolts (kV) and 40 kV, and activate an optical detector to identify the one or more substances in the liquid sample based on an optical signal from the plasma discharge that is collected by an optical collector.
G01N 21/73 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light thermally excited using plasma burners or torches
G01N 21/75 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
G01N 21/85 - Investigating moving fluids or granular solids
G01N 21/71 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light thermally excited
H05H 1/16 - Arrangements for confining plasma by electric or magnetic fieldsArrangements for heating plasma using applied electric and magnetic fields
H05H 1/18 - Arrangements for confining plasma by electric or magnetic fieldsArrangements for heating plasma using applied electric and magnetic fields wherein the fields oscillate at a very high frequency, e.g. in the microwave range
34.
A NONPERTURBING SENSOR FOR CONTINUOUS MONITORING OF IMMUNE BIOMARKERS IN BIOFLUIDS
A biosensor for in situ continuous monitoring of molecular biomarkers includes a flexible organic or inorganic layer, and a biorecognition element microarray placed on the organic or inorganic layer. In some aspects, the flexible layer is placed upon a disk that may be made of, for example, one or more of poly dimethylsiloxane (PDMS), silicone, polyurethane, polymers, and hydrogels. The organic or inorganic layer enables the immobilization of biorecognition elements, such as polystyrene (PS) film comprises functional groups from Gamma irradiation to increase biorecognition element binding. The biorecognition elements may include, for example, one or more of an antibody, aptamer, peptide, molecularly imprinted polymers, nucleic acid.
G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
B81C 1/00 - Manufacture or treatment of devices or systems in or on a substrate
C07K 16/24 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
A61K 31/4406 - Non-condensed pyridinesHydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A61K 31/4545 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
A61K 31/4985 - Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
C07D 417/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
36.
COMPOSITIONS AND METHODS FOR GENOME EDITING ACROSS GRAFT-JUNCTIONS
Provided are compositions and methods for modifying a plant genome. Methods and compositions are also provided for delivering genome editing components across graft junctions and generating genome modified plants in the presence of a selection agent without integration of a selectable marker gene into the genome. Recombinant DNA constructs for modifying a plant genome and plants comprising the same are further provided.
C12Q 1/6827 - Hybridisation assays for detection of mutation or polymorphism
C12Q 1/6895 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae
A01H 4/00 - Plant reproduction by tissue culture techniques
Disclosed herein are antisense oligonucleotides that are capable of inducing expression of ubiquitin-protein ligase E3A (UBE3A) from the paternal allele in animal or human neurons. The oligonucleotides target the suppressor of the UBE3A paternal allele by hybridization to SNHG14 long non-coding RNA at the 5′-end of UBE3A-AS, which is downstream of SNORD115-45 snoRNA. Also disclosed are pharmaceutical compositions and methods for treatment of Angelman syndrome.
C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
Board of Regents, The University of Texas System (USA)
Inventor
Haas, Derek
Robison, Jordan
Biegalski, Steven
Head, Timothy
Towell, Rusty
Clarno, Kevin
Petrovic, Bojan
Tsvetkov, Pavel
Scherr, Jonathan
Kimber, Mark
Abstract
An integral molten salt nuclear reactor includes a drain tank section configured to hold a volume of fuel salt. The integral molten salt nuclear reactor further includes a reactor section configured to receive the volume of fuel salt from the drain tank and cause fission reactions that heats the molten salt. The integral molten salt nuclear reactor further includes a heat exchange section configured to receive a flow of the heated fuel salt from the reactor section and remove heat therefrom.
G21C 1/32 - Integral reactors, i.e. reactors wherein parts functionally associated with the reactor but not essential to the reaction, e.g. heat exchangers, are disposed inside the enclosure with the core
G21C 7/30 - Control of nuclear reaction by displacement of reactor fuel or fuel elements
39.
CORN ENDOTYPE-DERIVED POLYPEPTIDES CAPABLE OF METABOLIZING FUMONISIN
Polynucleotides and polypeptides conferring the ability to detoxify or metabolize the mycotoxin fumonisin are provided, as are constructs, compositions, and plants comprising the polynucleotides and polypeptides. Also provided are plants having the ability to detoxify fumonisin, methods of conferring fumonisin detoxification, methods of controlling fumonisin contamination, and kits and methods for identification of plants having the ability to detoxify fumonisin.
C12Q 1/6895 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (USA)
Inventor
Haas, Derek
Robison, Jordan
Biegalski, Steven
Head, Timothy
Towell, Rusty
Clarno, Kevin
Petrovic, Bojan
Tsvetkov, Pavel
Scherr, Jonathan
Kimber, Mark
Abstract
An integral molten salt nuclear reactor includes a drain tank section configured to hold a volume of fuel salt. The integral molten salt nuclear reactor further includes a reactor section configured to receive the volume of fuel salt from the drain tank and cause fission reactions that heats the molten salt. The integral molten salt nuclear reactor further includes a heat exchange section configured to receive a flow of the heated fuel salt from the reactor section and remove heat therefrom.
G01C 3/30 - Measuring distances in line of sightOptical rangefinders using a parallactic triangle with fixed angles and a base of variable length at, near, or formed by, the object with provision for reduction of the distance into the horizontal plane with adaptation to the measurement of the height of an object, e.g. tacheometers
G21C 3/54 - Fused salt, oxide, or hydroxide compositions
G21C 7/30 - Control of nuclear reaction by displacement of reactor fuel or fuel elements
G21C 9/00 - Emergency protection arrangements structurally associated with the reactor
G21C 9/02 - Means for effecting very rapid reduction of the reactivity factor under fault conditions, e.g. reactor fuse
Embodiments of the disclosure include compositions comprising peptides with an N-terminal capping motif or with the combination of an N-terminal capping motif and a C-terminal capping motif, and methods for synthesizing the peptides. The capping motifs can impart helicity to peptides that otherwise do not exhibit helicity. The helix capping motifs are conformationally rigid, improve peptide serum stability, and increase cell permeability of peptides.
Polynucleotides and polypeptides conferring the ability to detoxify or metabolize the mycotoxin fumonisin are provided, as are constructs, compositions, and plants comprising the polynucleotides and polypeptides. Also provided are plants having the ability to detoxify fumonisin, methods of conferring fumonisin detoxification, methods of controlling fumonisin contamination, and kits and methods for identification of plants having the ability to detoxify fumonisin.
The present disclosure pertains to a circulating tumor cell (CTC) microfluidic platform that is used for the detection of CTCs, enumeration of CTCs in a sample, characterization of biophysical properties, CTC cell size, CTC cell membrane deformability, stresses on CTC cell membranes, adhesion stress on CTC cells, normal stress of CTC cells, or combinations thereof.
Embodiments of the disclosure include compositions comprising peptides with C-terminal capping motifs, and methods for making the compositions. The capping motifs impart helicity to C-termini of peptides that otherwise do not exhibit helicity. The helix capping motifs are conformationally rigid, stable in serum, and increase cell permeability of peptides.
In an embodiment, the present disclosure pertains to a droplet system, apparatus, or fluid sample testing system to accomplish high-precision and high-efficiency droplet manipulation (e.g., greater than 99% platform operation efficiency). In some embodiments, the droplet system, apparatus, or fluid sample testing system includes at least one microfluidic channel or chamber and at least one interdigitated electrode (IDE) that can create a localized electric field below and/or within at least one fluidic channel or chamber. In some embodiments, this allows size-specific and/or size-dependent droplet manipulation.
Board of Regents, The University of Texas System (USA)
Inventor
Kelly, Ryan
Biegalski, Steven
Brownfield, Ryan
Farrar, Kraig
Gates, Tyler
Haas, Derek
Scherr, Jonathan
Shoemate, Jack
Tsvetkov, Pavel
Abstract
A method and system for calibrating nuclear instrumentation of a reactor is disclosed. The system comprises a reactor configured to operate at a low power level and an external heater configured to heat the reactor to its operating temperature and maintain the reactor in a critical state. The reactor maintains its temperature at a steady state by repeating steps of reducing the heater's power and increasing the reactor's power by changing one or more reactivity settings, wherein the reduced heater's power is compensated by using the increased power generated by the reactor itself. The nuclear instrumentation is configured to measure the reactor's output power and compare it with the calculated reactor's power. Based on the discrepancy between the calculated power and the measured power exceeds a threshold; and the nuclear instrumentation is appropriately calibrated by adjusting one or more settings.
Disclosed are RNA inhibitors, such as small interfering RNAs (siRNAs) and short hairpin RNAs (shRNAs) specific for RND3, alternatively referred to as RhoE. Also disclosed are methods of treating subjects by administering RNA inhibitors. Further disclosed are methods of detecting potential modulators of RND3.
C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
G01N 33/573 - ImmunoassayBiospecific binding assayMaterials therefor for enzymes or isoenzymes
48.
CERVICAL SPINAL FIXATION ASSEMBLY FOR LAMINAR SCREWS
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (USA)
THE TEXAS A&M UNIVERSITY SYSTEM (USA)
Inventor
Tatsui, Claudio E.
Bird, Justin E.
Rhines, Laurence D.
North, Robert Y.
Alvarez-Breckenridge, Christopher A.
Bohle, Kihoon
Mansfield, Hunter
Abstract
A spinal fixation assembly for use with a cervical fixation rod and methods of use thereof. The spinal fixation assembly can comprise a washer comprising a first side and a second side opposing the first side, the first side comprising a first set of teeth arranged longitudinally, the second side comprising a second set of teeth arranged circumferentially and a laminar wing comprising a slot configured to receive a fastener therethrough, wherein the laminar wing extends laterally from the cervical fixation rod when coupled thereto, the laminar wing adjustably coupled to the cervical fixation rod via the washer such that the first set of teeth are configured to allow a longitudinal position of the laminar wing to be adjusted relative to the cervical fixation rod and the second set of teeth are configured to allow an orientation of the laminar wing to be adjusted relative to the cervical fixation rod.
Methods and compositions for the treatment of Brucella induced diseases and disorders are disclosed herein. In preferred embodiments, the invention relates to a vaccine compositions and methods of vaccinating comprising: a Brucella canis comprising one or more attenuating gene knockouts; and a pharmaceutically acceptable vaccine carrier.
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (USA)
Inventor
Kelly, Ryan
Haas, Derek
Scherr, Jonathan
Shoemate, Jack
Tsvetkov, Pavel
Biegalski, Steven
Brownfield, Ryan
Farrar, Kraig
Gates, Tyler
Abstract
A method and system for calibrating nuclear instrumentation of a reactor is disclosed. The system comprises a reactor configured to operate at a low power level and an external heater configured to heat the reactor to its operating temperature and maintain the reactor in a critical state. The reactor maintains its temperature at a steady state by repeating steps of reducing the heater's power and increasing the reactor's power by changing one or more reactivity settings, wherein the reduced heater's power is compensated by using the increased power generated by the reactor itself. The nuclear instrumentation is configured to measure the reactor's output power and compare it with the calculated reactor's power. Based on the discrepancy between the calculated power and the measured power exceeds a threshold; and the nuclear instrumentation is appropriately calibrated by adjusting one or more settings.
A method of producing a lignin composition comprising contacting a lignin obtained from a renewable resource with an aqueous fluid a plurality of times to produce a washed lignin; contacting the washed lignin with an acid under conditions suitable for formation of an acid washed lignin; contacting the acid washed lignin with one or more cellulases to form a pretreated lignin; and fermenting the pretreated lignin to form a crosslinked high molecular weight lignin. A composite material comprising a high molecular weight crosslinked lignin and at least one material selected from the group consisting of carbon fiber, polymers, a precursor for carbon-based materials, nanomaterials, cement, concrete and combinations thereof.
A metal hydride storage system (MHSS) and a method for refueling the MHSS includes obtaining a parameter vector comprising a first state of a metal hydride storage system (MHSS), and a measurable output of the MHSS; sending the parameter vector to a control algorithm, wherein the control algorithm includes a first data structure and a second data structure, wherein the first data structure corresponds to a plurality of critical regions, wherein the second data structure corresponds to a plurality of piecewise affine functions, wherein the affine functions corresponds to a control action; searching the first data structure with the parameter vector; selecting a critical region based on searching the first data structure; selecting, from the second data structure, a piecewise affine function corresponding to the selected critical region; and calculating a control action based on the affine function, where the control action comprises controlling at least one controlled parameter.
Chalcogenide waveguides with high width-to-height aspect ratios and a smooth exposed surfaces can serve as mid-infrared evanescent-absorption-based sensors for detecting and identifying volatile organic compounds and/or determining their concentration, optionally in real-time. The waveguide sensors may be manufactured using a modified sputtering process in which the sputtering target and waveguide substrate are titled and/or laterally offset relative to each other and the substrate is continuously rotated.
Systems and methods for automated separation and recovery of compounds from solution are disclosed herein. In some embodiments, the system can use a pump in fluid/air communication with a chromatography column to dissolve and recover astatine from a solution containing astatine, bismuth, and nitric acid. The system can be in communication with a controller that can automate and/or remotely signal each component of the system to execute the recovery without manual user inputs.
Blood coagulation testing can be performed by measuring, based on video of a blood sample flowing in a microfluidic channel, the time it takes until flow stops due to clotting. In various embodiments, such measurements are enabled by a low-cost testing system that includes a microfluidic cartridge and uses a smartphone or similar device for video acquisition, in conjunction with a lighting module for illuminating the microfluidic channel and a 3D-printed platform for holding and positioning and orienting the cartridge, lighting module, and smartphone in fixed special relation to each other.
Disclosed are example efficient circuits that produce spark discharges for hydrocarbon conversion (or treatment of other mixtures) using a high-voltage rectified DC supply to discharge a capacitor (either internal or external) across a two-electrode gap, optimized to minimize waste energy by operating in a constant current, approximately-constant current, or constant power mode. The circuits may operate off of a standard electrical supply line (e.g. 120 VAC or 240 VAC, 60 Hz, single-phase or multi-phase). The disclosed approach is scalable to any number of discharge gaps while maintaining similar pulse characteristics and electrical efficiency.
C10G 15/08 - Cracking of hydrocarbon oils by electric means, electromagnetic or mechanical vibrations, by particle radiation or with gases superheated in electric arcs by electric means or by electromagnetic or mechanical vibrations
B01J 19/08 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor
57.
EUKARYOTIC ELONGATION FACTOR-2 KINASE AS A CYTOTOXIC T LYMPHOCYTES BOOSTER
In an embodiment, the present disclosure pertains to a method of reducing cytocidal activity of cells. In some embodiments, the method includes altering eukaryotic elongation factor-2 kinase (eEF-2K) in a subject and inducing a reduction of cytocidal activity of cytotoxic T cells (CTLs) in the subject. In some embodiments, the altering of eEF-2K in the subject can include a decrease of eEF-2K in the subject.
In one aspect, the disclosure relates to a universal method for biomarker extraction and detection from clinical samples using magnetic nanoparticles (MNPs) coupled with a locked aptamer-initiator approach. The MNP bound locked aptamer undergoes a conformational change in the presence of the target biomarker and the unfolded initiator triggers a hybridization chain reaction with a structurally stabilized catalytic trimeric triplex DNAzyme hairpin. Amplicons from the hybridization chain reaction can be incubated with hemin to obtain a stable triplex structure that has horseradish peroxidase-like activity in the presence of H2O2 and a substrate molecule. The intensity of the signal is directly proportional to the amount of biomarker present. Binding one or more reagents on a nanoparticle can be coupled with this approach for use in a microfluidic or paper fluidic platform. In any of these aspects, the assay can detect as low as femtogram amounts of biomarker from the clinical sample.
In an embodiment, the present disclosure pertains to a wearable sensor. In some embodiments, the wearable sensor includes a double-sided adhesive layer, a paper microfluidic layer, and an encapsulation layer. In an additional embodiment, the present disclosure pertains to a method of biochemical analysis. In general, the method includes collecting biofluid from a subject via a wearable sensor and quantifying the biofluid. In some embodiments, the wearable sensor includes a double-sided adhesive layer and a paper microfluidic layer having a microfluidic channel in a serpentine configuration. In some embodiments the microfluidic channel includes an inlet to receive the biofluid, an outlet to collect the excess biofluid, and a plurality of plasmonic sensors.
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
Method and systems for situational awareness are disclosed. An example method includes receiving a first set of sensor data from a plurality of internal data sources that describes geospatial locations of objects within an airspace. The method also includes receiving event data from an external data source over a network describing publicly available information affecting the airspace. The method also includes receiving a second set of sensor data from another external data source operated by a user that describes the geospatial location of a user-operated object. The method also includes generating object metadata based on the first and second sets of sensor data and the event data. The method also includes streaming at least a subset of the object metadata to the computing device of the user. The object metadata is processed to generate a real-time three-dimensional rendering of the airspace, including the objects and the user-operated object.
A method and system for decoding low density parity check (LDPC) codes. A method includes performing block parallel processing that initiates processing all non-zero block columns of a plurality (M) of rows of a layer of an LDPC matrix in each clock cycle, where M≤p, and p is a total number of rows in a layer of the LDPC matrix; and updating a P message responsive to determination of a final state for each row of the LDPC matrix. The LDPC matrix includes layers, each comprising a plurality (M) of rows that are processed per clock cycle. Each of the plurality of rows of each of the layers is datawise independent of the rows processed during a previous NP_MAX clock cycles and at least one row in each layer is datawise dependent on a row of an immediately preceding layer, and NP_MAX is greater than one.
H03M 13/11 - Error detection or forward error correction by redundancy in data representation, i.e. code words containing more digits than the source words using block codes, i.e. a predetermined number of check bits joined to a predetermined number of information bits using multiple parity bits
H03M 13/00 - Coding, decoding or code conversion, for error detection or error correctionCoding theory basic assumptionsCoding boundsError probability evaluation methodsChannel modelsSimulation or testing of codes
A method for reconstructing a three-dimensional (3D) of a sample includes displacing an outer surface of the sample at a desired sample, repeatedly activating an ultraviolet stroboscopic illuminator to produce ultraviolet excitation light at a frequency that is based on the speed of the sample, repeatedly activating a pair of laterally spaced cameras of a stereoscopic imaging unit as the outer surface of the sample is displaced to capture a plurality of 2D images of different sections of the outer surface of the sample, and reconstructing a 3D image of the sample from the plurality of 2D images of the different sections captured by the pair of cameras.
H04N 13/167 - Synchronising or controlling image signals
H04N 13/239 - Image signal generators using stereoscopic image cameras using two 2D image sensors having a relative position equal to or related to the interocular distance
H04N 13/254 - Image signal generators using stereoscopic image cameras in combination with electromagnetic radiation sources for illuminating objects
63.
RECYCLING CARBON FIBER COMPOSITES USING ELECTROMAGNETIC FIELDS
In an embodiment, the present disclosure pertains to a method of recycling that includes applying an electromagnetic field to a composite material having carbon fiber therein, heating the composition, degrading a matrix of the composite material, and recovering the carbon fiber from the composite material. In an additional embodiment, the present disclosure pertains to a method of non-contact recycling that includes applying an electromagnetic field to a composite material having carbon fiber therein with an electromagnetic applicator via at least one of direct current or alternating current, heating the composition, degrading a matrix of the composite material, and recovering the carbon fiber from the composite material. In some embodiments, the electromagnetic field is applied in a non-contact manner. In some embodiments, the heating is locally induced heating that includes increasing the temperature inside the composite material via an inside-out method thereby initiating pyrolysis within the composite material.
B29K 105/08 - Condition, form or state of moulded material containing reinforcements, fillers or inserts of continuous length, e.g. cords, rovings, mats, fabrics, strands or yarns
BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM (USA)
UT- BATTELLE, LLC (USA)
Inventor
Varanasi, Venu
Aswath, Pranesh
Maginot, Megen
Lavrik, Nickolay V.
Abstract
Amorphous SiOx (SiO2), SiONx, silicon nitride (Si3N4), surface treatments are provided, on both metal (titanium) and non-metal surfaces. Amorphous silicon-film surface treatments are shown to enhance osteoblast and osteoblast progenitor cell bioactivity, including biomineral formation and osteogenic gene panel expression, as well as enhanced surface hydroxyapatite (HA) formation. A mineralized tissue interface is provided using the amorphous silicon-based surface treatments in the presence of osteoblasts and provides improved bone cell generation/repair and improved interface for secure attachment/bonding to bone. Methods for providing PEVCD-based silicon overlays onto surfaces are provided. Methods of increasing antioxidant enzyme (e.g., superoxide dismutase) expression at a treated surface for enhanced healing are also provided. Continuous generation and release of Si4+ ion into an in vitro or in vivo environment in the presence of osteoblasts/osteoblast progenitor cells, methods of employing same for enhancing the rate of bone healing/bone regeneration, is also described.
The digital human workplace solution is deployed in a customer service setting and involves a computer programmed with a digital human that is displayed to interact with the customer and adapt to inputs providing information about the user or the environment. The digital human workforce solution is also programmed to interface with one or more databases of information that can be used during the customer service interaction.
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
66.
METHOD FOR CREATING CRUDE OIL SYNTHESIZED FLUID HAVING SURFACTANT AND DEMULSIFICATION PROPERTIES
A high voltage discharge generating a plasma wave front is disposed within a headspace over an oil-containing liquid in order to create various chemical changes within the headspace, and ultimately within the liquid in order to inactivate various microbes, synthesize new chemicals, speed separation of a mixture, and aid in oil extraction. Such a discharge may be repeated at an optimum duration and duty-cycle to maximize the chemical effects of the non-equilibrium plasma at a substantially lower temperature than for an equilibrium plasma.
C10G 33/02 - De-watering or demulsification of hydrocarbon oils with electrical or magnetic means
B01J 19/00 - Chemical, physical or physico-chemical processes in generalTheir relevant apparatus
B01J 19/08 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor
C09K 8/584 - Compositions for enhanced recovery methods for obtaining hydrocarbons, i.e. for improving the mobility of the oil, e.g. displacing fluids characterised by the use of specific surfactants
C10G 33/04 - De-watering or demulsification of hydrocarbon oils with chemical means
The digital human workplace solution is deployed in a customer service setting and involves a computer programmed with a digital human that is displayed to interact with the customer and adapt to inputs providing information about the user or the environment. The digital human workforce solution is also programmed to interface with one or more databases of information that can be used during the customer service interaction.
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
G06F 3/0487 - Interaction techniques based on graphical user interfaces [GUI] using specific features provided by the input device, e.g. functions controlled by the rotation of a mouse with dual sensing arrangements, or of the nature of the input device, e.g. tap gestures based on pressure sensed by a digitiser
A computer-implemented method for defect identification based on a defect category driven image analysis. The method includes receiving an image of a product having a manufacturing process applied to the product; categorizing the image based on an attribute of the product in the image; selecting, based on the categorizing, a subset of image processing methods; initiating application of the selected subset of image processing methods to the image; receiving output images, each from the application of one of the selected subset of image processing methods; determining scores, each for one of the subset of the image processing methods, wherein each of the scores is based on metrics associated with different image qualities of a respective one of the output images; selecting an image processing method from the subset of imaging processing methods based on the scores; and identifying a defect in the product based on the selected imaging processing method.
The present disclosure provides a vascular graft comprising i) one or more extracellular matrix compositions and ii) one or more hydrogels. In particular, the vascular grafts of the present disclosure can be functionalized and/or be completely biologic. The disclosure also provides methods of administering the vascular grafts as well as methods for forming the vascular grafts.
A61L 27/54 - Biologically active materials, e.g. therapeutic substances
A61L 33/00 - Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of bloodMaterials for such treatment
70.
METHODS AND COMPOSITIONS TARGETING NUCLEUS ACCUMBENS-ASSOCIATED PROTEIN-1 FOR TREATMENT OF AUTOIMMUNE DISORDERS AND CANCERS
Provided herein are methods of for enhancing or inducing an anti-tumor response or treating an autoimmune disorder by administering a therapeutically effective amount of an inhibitor of NAC 1. Also, provided herein are methods of enhancing effectiveness of a vaccine in a subject by administering to the subject a therapeutically effective amount of an inhibitor of NAC 1. Inhibitors of NAC1 can include a chemical agent, such as a composition containing NIC3, or a biological agent that inhibit the function of NAC1 protein, such as an isolated antibody or its binding fragment thereof that binds to NAC1. Inhibitors of NAC 1 can include a biological agent that reduces the expression of NAC1 gene, such as a NAC 1-targeted siRNA administered as a nanoliposome or a CRISPR/Cas-based genome editing composition targeting the NAC1 Gene.
The present invention provides a copolymer, preferably a degradable copolymer, comprising at least first and second repeat units and/or derived from at least first, second, and third monomers.
In an embodiment, a method for measuring parameters of a liquid, where the method includes measuring pressure drops across a flow meter, measuring pressure upstream of the flow meter, and identifying at least one liquid parameter based, at least in part, on a correlation of a change in a multiphase flow parameter to pulse output. In an additional embodiment, a measuring apparatus for measuring parameters of a liquid, where the measuring apparatus includes an electronic control operable to measure pressure drops across the measuring apparatus, measure pressure upstream of the measuring apparatus, and correlate a change in a multiphase parameter to measured pulse output of the measuring apparatus.
G01F 1/10 - Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by using mechanical effects using rotating vanes with axial admission
G01F 1/34 - Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by using mechanical effects by measuring pressure or differential pressure
The present invention provides a polymer, preferably a degradable polymer, derived from monomers (A) and (B) and/or comprising a repeat unit of formula (ii) and at least one terminal group of formula (II).
Disclosed are methods and compositions for detecting glomerular disease in dogs and effectively treating dogs with glomerular diseases such as membranoproliferative immune complex-mediated glomerulonephritis (MPGN). Methods and compositions for detecting glomerular or tubular damage in cats and effectively treating cats with glomerular or tubular damage are also provided.
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
A61K 31/573 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
An autonomous landing system includes a vertical landing aircraft, a visual cue coupled to an offshore landing platform and including a visual indicator located that extends vertically across a horizon and is maintained parallel with the horizon, and an autonomous control system configured to control a position of the aircraft with respect to the visual indicator to maneuver the aircraft into a hovering, predefined landing position above the offshore landing platform, and control the position of the aircraft with respect to the visual indicator to cause the aircraft to descend from the landing position and land on the offshore landing platform.
The present invention provides a copolymer, preferably a degradable copolymer, comprising at least first and second repeat units and/or derived from at least first, second, and third monomers.
Tumor resection is commonly practiced to prevent the progression of cancer. However, there are post-surgery concerns including the formation of a void that can allow cancer cells to escape at the surgery site, which increases the risk of metastasis. To counter this challenge, an embodiment includes a polyurethane-based shape memory foam as a tissue void-filling device that can also release anti-cancer drugs. Such foams may activate at body temperature and become malleable. Such properties may enable the foam to be shaped to precisely seal the tissue void and then serve as a drug-eluting device. Based on the drug composition with poly vinyl alcohol (PVA), the drug release profile from the foam may be altered depending on the application.
A combination micro/macro-fluidic analysis system with one or more of a droplet transition unit, a droplet cleaving unit, a droplet synchronization, and a merging unit to enable highly efficient complex droplet microfluidic assays.
A method for predictive fire control, comprising identifying a plurality of wildfire risk points on a power grid, calculating a route for an unmanned aerial vehicle (UAV) to intersect with a maximum number of points as a function of a range of the UAV, controlling the UAV to traverse the route, monitoring one or more sensors for an indication of a wildfire event and controlling the UAV to release a fire retardant on the fire.
A62C 3/02 - Fire prevention, containment or extinguishing specially adapted for particular objects or places for area conflagrations, e.g. forest fires, subterranean fires
B64D 1/16 - Dropping or releasing powdered, liquid or gaseous matter, e.g. for fire-fighting
G05D 1/656 - Interaction with payloads or external entities
G05D 105/55 - Specific applications of the controlled vehicles for emergency activities, e.g. search and rescue, traffic accidents or fire fighting
Augmented-reality (AR) instructions for assembly of a physical object may be based on an assembly sequence divided into multiple assembly phases, using separate computational three-dimensional (3D) registration models (e.g., object recognition models) for the different phases. A user may be guided step by step through the assembly sequence, using a step counter to keep track of where in the assembly sequence the user is. In each step, an AR image may be created by rendering, overlaid onto the camera image, a virtual model of a part of the physical object to be added during the step, spatially registered with the physical object in its partially assembled state.
G06F 3/04815 - Interaction with a metaphor-based environment or interaction object displayed as three-dimensional, e.g. changing the user viewpoint with respect to the environment or object
G06T 5/60 - Image enhancement or restoration using machine learning, e.g. neural networks
G06T 17/20 - Wire-frame description, e.g. polygonalisation or tessellation
G06T 19/20 - Editing of 3D images, e.g. changing shapes or colours, aligning objects or positioning parts
G06V 10/24 - Aligning, centring, orientation detection or correction of the image
G06V 20/20 - ScenesScene-specific elements in augmented reality scenes
G06F 3/0484 - Interaction techniques based on graphical user interfaces [GUI] for the control of specific functions or operations, e.g. selecting or manipulating an object, an image or a displayed text element, setting a parameter value or selecting a range
G06V 10/75 - Organisation of the matching processes, e.g. simultaneous or sequential comparisons of image or video featuresCoarse-fine approaches, e.g. multi-scale approachesImage or video pattern matchingProximity measures in feature spaces using context analysisSelection of dictionaries
G09B 5/02 - Electrically-operated educational appliances with visual presentation of the material to be studied, e.g. using film strip
H04N 23/63 - Control of cameras or camera modules by using electronic viewfinders
In an embodiment, the present disclosure pertains to a supercapacitor composed of a cathode material, a gel electrolyte, and a zinc foil anode. In some embodiments, the cathode material, the gel electrolyte, and the zinc foil anode are in a multilayered configuration. In some embodiments, the cathode and anode materials provide load-bearing capability. In an additional embodiment, the present disclosure pertains to a method of making a supercapacitor. In general, the method includes fabricating a cathode material, preparing a gel electrolyte, coating a zinc foil electrode with the gel electrolyte, and sandwiching the zinc foil electrode with the cathode material. In some embodiments, the sandwiching forms a multilayered configuration composed of the cathode material, the gel electrolyte, and the zinc foil anode.
A mechanical and electrochemical testing apparatus includes a tensile frame having a first grip and a second grip. An electrochemical cell is disposed between the first grip and the second grip. The electrochemical cell includes a working electrode port and a counter electrode port. An electrolyte is disposed in the electrochemical cell. A working electrode is coupled to the first grip and the second grip. The working electrode is in contact with the electrolyte in the working electrode port. A counter electrode is disposed in the counter electrode port. A potentiostat is coupled to the working electrode and the counter electrode.
G01N 27/27 - Association of two or more measuring systems or cells, each measuring a different parameter, where the measurement results may be either used independently, the systems or cells being physically associated, or combined to produce a value for a further parameter
G01N 3/08 - Investigating strength properties of solid materials by application of mechanical stress by applying steady tensile or compressive forces
G01N 27/49 - Systems involving the determination of the current at a single specific value, or small range of values, of applied voltage for producing selective measurement of one or more particular ionic species
H01M 10/42 - Methods or arrangements for servicing or maintenance of secondary cells or secondary half-cells
85.
SELECTIVE DEPOSITION AND FUSION ADDITIVE MANUFACTURING METHOD WITH REDUCED BINDER CONTENT
A SDFAM method includes forming a patterned layer of metallic paste on a build structure. The metallic paste has a solvent and a binder. The method also includes removing the solvent and the binder from the metallic paste to generate a patterned layer of metallic powder. The SDFAM method also includes applying thermal energy to the patterned layer of metallic powder to fuse the patterned layer of metallic powder into a patterned layer of solid metallic build material, and repeating the forming, the removing, and the applying to form a plurality of patterned layers of solid metallic build material to create an object.
AAAR antagonist BQ123 only blocks but is not able to reverse the vasoconstriction to ET-1. In contrast, ROCK inhibitors (e.g., H-1152) effectively reverse arteriolar constriction to ET-1. Therefore, ROCK inhibition is a potent and specific choice for treating coronary ischemic diseases (abnormal vasoconstriction) associated with microvascular dysfunction with overproduced ET-1. ROCK inhibitors may also be used to treat microvascular diseases related to diabetic retinopathy and microvascular dysfunction from cancer therapy or immunosuppressive medications. Since H-1152 can also reduce the basal tone of the microvasculature, ROCK inhibitors are also good diagnostic agent(s) when used during angiogram or by noninvasive methods.
Disclosed are methods and compositions for detecting glomerular disease in dogs and effectively treating dogs with glomerular diseases such as amyloidosis, glomerulosclerosis, or immune complex-mediated glomerulonephritis. miRNAs associated with glomerular disease are also provided, as are kits, and methods of use.
Architectures of millimeter-wave (mm-wave) fully-integrated frequency-division duplex (FDD) transmitting-receiving (T/R) front-end (FE) modules include a duplexer (DUX), power amplifier (PA), and low noise amplifier (LNA) on a single semiconductor substrate to facilitate the development of system on a chip (SoC) for mm-wave 5th Generation (5G) wireless communications applications. The first FE module adopts a passive DUX consisting of Wilkinson power divider and ground-center-tap transformer to achieve high isolation between PA output and LNA inputs. Another FE module combines the advantages of passive DUX and power-efficient cancellation circuits to accomplish high TX-RX isolation and low noise performance at the same time. The DUX can stand alone as a single unit in a system and is used together with external PA and LNA provided in the system, or it can include its own internal PA and LNA to form a DUX FE module.
A method of characterizing brain activity includes receiving an electroencephalogram (EEG) output. In addition, the method includes determining a mathematical model of a brain using the EEG output, wherein the mathematical model comprises a plurality of ordinary differential equations (ODEs) that are determined based on the EEG output. Further, the method includes characterizing brain activity of a subject using the mathematical model.
A method of fabrication processing a pre-preg material includes applying electromagnetic heating to a composition including a fiber and a resin. The electromagnetic heating is conducted with at least one fringing field capacitor utilizing radio frequency (RF) alternating current (AC) and controlling cross-linking of the resin in the composition via the electromagnetic heating.
B29B 13/08 - Conditioning or physical treatment of the material to be shaped by using wave energy or particle radiation
B29B 11/16 - Making preforms characterised by structure or composition comprising fillers or reinforcements
B29C 35/08 - Heating or curing, e.g. crosslinking or vulcanising by wave energy or particle radiation
B29C 70/50 - Shaping or impregnating by compression for producing articles of indefinite length, e.g. prepregs, sheet moulding compounds [SMC] or cross moulding compounds [XMC]
C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules
C08J 3/28 - Treatment by wave energy or particle radiation
C08J 5/24 - Impregnating materials with prepolymers which can be polymerised in situ, e.g. manufacture of prepregs
The present disclosure provides pharmaceutical compositions comprising a live attenuated bacterial strain of Brucella melitensis, in particular a live attenuated bacterial strain of Brucella melitensis is Brucella melitensis 16M ΔvjbR (BmΔvjbR). Methods of utilizing the live attenuated bacterial strain of Brucella melitensis for treatment of a patient are also provided, including wherein the patient is in need of treatment for cancer, an autoimmune disorder, and/or an inflammatory disorder.
Technologies for multimodal sensing include a wearable device having a flexible substrate and at least one multimodal sensor coupled to the flexible substrate. The multimodal sensor includes a photoplethysmography sensor and a bioimpedance sensor. The wearable device may include context sensors such as an accelerometer, a gyroscope, a temperature sensor, or a pressure sensor. The multimodal sensor may include an integrated pressure sensor. A processor of the wearable device is configured to receive sensor data from the photoplethysmography sensor and the bioimpedance sensor of the multimodal sensor that is indicative of a pulse curve of a user. The processor is further configured to correct the sensor data based on data received from the context sensors and to determine blood pressure data based on the corrected sensor data. The processor may be configured to store the blood pressure data or to transmit the blood pressure data to a remote computing device.
Low-Loss Switching for Circuits, Low-Loss Switching for Nuclear Magnetic Resonance Radio Frequency Coils, Methods of Use, Methods of Making, Systems, and Devices
The present provides for a stimuli-responsive switches, circuits including a stimuli-responsive switch, systems include the circuit, method of switching frequencies in a nuclear magnetic resonance system, and the like. The stimuli-responsive switch can be made of a stimuli-responsive material, where a conductive material can be moved and brought in contact with disconnected conductive paths by the stimuli-responsive material so that upon stimulation a conductive path can be achieved.
G01R 33/36 - Electrical details, e.g. matching or coupling of the coil to the receiver
H01H 36/00 - Switches actuated by change of magnetic field or of electric field, e.g. by change of relative position of magnet and switch, by shielding
A process for continuously upgrading heavy oil to produce light hydrocarbon gases which are recycled in the process as a carrier gas used in spark-discharge hydrocarbon cracking within the process. The process also produces light hydrocarbon liquids which are used to upgrade the heavy oil. An apparatus for continuously upgrading heavy oil to produce light hydrocarbon gases which are recycled in the as a carrier gas used in spark-discharge hydrocarbon cracking within the apparatus. The apparatus also produces light hydrocarbon liquids which are used to upgrade the heavy oil.
C10G 15/12 - Cracking of hydrocarbon oils by electric means, electromagnetic or mechanical vibrations, by particle radiation or with gases superheated in electric arcs with gases superheated in an electric arc, e.g. plasma
C10G 55/04 - Treatment of hydrocarbon oils, in the absence of hydrogen, by at least one refining process and at least one cracking process plural serial stages only including at least one thermal cracking step
96.
SELECTIVE SMALL MOLECULE AGONISTS AND PARTIAL AGONISTS OF TRK RECEPTORS
The present disclosure relates to macrocyclic compounds, pharmaceutical compositions containing macrocyclic compounds, and methods of using macrocyclic compounds to treat disease, such as diseases of the eye.
C07K 5/062 - Dipeptides the side chain of the first amino acid being acyclic, e.g. Gly, Ala
C07K 5/072 - Dipeptides the side chain of the first amino acid containing more carboxyl groups than amino groups, or derivatives thereof, e.g. Asp, Glu, Asn
C07K 5/083 - Tripeptides the side chain of the first amino acid being acyclic, e.g. Gly, Ala
C07K 5/103 - Tetrapeptides the side chain of the first amino acid being acyclic, e.g. Gly, Ala
97.
Genetically Engineered Eukaryotic Cells and Cell Lines and Uses Thereof
Provided herein are stably-modified cell lines such as HEK293 cell lines. The cell lines are modified with an insertion, such as, a transposon containing an inducible recombinase and a promoter and one of a DNA cassette encoding an excisable mitogen, a DNA cassette encoding an inducible gene of interest or a DNA cassette encoding the excisable mitogen and the inducible gene of interest. The stably-modified cell lines are used in methods for producing a biological medical product, for example, in a scalable process for producing biopharmaceuticals.
A method of forming a composition having exfoliated nanoplatelets functionalized with covalently bound surface-modifiers, includes exfoliating a layered nanoclay is exfoliated with a surfactant. The method also includes reacting the exfoliated layered nanoclay with a surface modifier comprising one or more of an epoxide, a silane, or an isocyanate.
A system for customer notification system based on outage state of risk prediction, comprising a correlator system operating on a processor and configured to receive uncorrelated outage data, weather data and graph data and to generate geographically and temporally correlated outage data, weather data and graph data. A machine learning system operating on a processor and configured to receive geographically and temporally correlated outage data, weather data and graph data and forecast data and to generate prediction data. A state of risk system operating on a processor and configured to receive the prediction data and to generate state of risk data. A customer notification system operating on a processor and configured to receive the state of risk data and to generate customer notifications as a function of the state of risk.
G06Q 10/04 - Forecasting or optimisation specially adapted for administrative or management purposes, e.g. linear programming or "cutting stock problem"
100.
DEVELOPMENT OF SPECIFICALLY TARGETED BINDERS AND ANTIMICROBIAL PEPTIDES (STAMPS) TO CONTROL CANDIDATUS LIBERIBACTER SPP.
The subject invention pertains to controlling and/or treating infections of Candidates Liberibacter spp. that leads to citrus greening in citrus plants, such as orange trees, grapefruit trees, lime trees, lemon trees and the like and potato zebra chip disease in potato and other tuber plants using specifically targeted antimicrobial peptides (STAMPs).
