C09K 5/06 - Substances qui subissent un changement d'état physique lors de leur utilisation le changement d'état se faisant par passage de l'état liquide à l'état solide, ou vice versa
C08J 3/02 - Production de solutions, dispersions, latex ou gel par d'autres procédés que ceux utilisant les techniques de polymérisation en solution, en émulsion ou en suspension
C08J 3/20 - Formation de mélanges de polymères avec des additifs, p. ex. coloration
C08J 3/24 - Réticulation, p. ex. vulcanisation, de macromolécules
An embodiment includes a system comprising: a substrate of a medical device; an un-foamed polyurethane coating directly contacting the substrate and fixedly attached to the substrate; a thermoset polyurethane shape memory polymer (SMP) foam, having first and second states, which directly contacts the polyurethane coating and fixedly attaches to the polyurethane coating; wherein the polyurethane coating fixedly attaches the SMP foam to the substrate. Other embodiments are described herein.
A method of delivering a recombinant adeno-associated virus (rAAV) or a biologic to cytosol of a plurality of cells is described. In an embodiment, the method comprises contacting the plurality of cells with the rAAV; contacting the plurality of cells with a cationic amphiphilic drug (CAD), thereby delivering the rAAV to the cytosol of the plurality of cells. In an embodiment, the method comprises contacting the plurality of cells with the biologic; contacting the plurality of cells with cell penetrating peptides (CPP); contacting the plurality of cells with a CAD, thereby delivering the biologic to the cytosol of the plurality of cells.
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
22). Also provided are methods for detecting and monitoring physiological changes via the wearable electronic skin and for diagnosing a disease or disorder based on the physiological changes.
The present disclosure relates to anti-fibrotic sialidase-inhibitor compounds and methods of preventing or inhibiting fibrosis using such compounds. The present disclosure also relates to methods of controlling the formation of fibrocytes or their activity using such compounds. The compounds may include both antibodies as well as small molecules. The methods may involve administering the compounds to a patient with or at risk of developing fibrosis in a manner that inhibits at least one sialidase in the patient.
A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 31/196 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe amino le groupe amino étant lié directement à un cycle, p. ex. acide anthranilique, acide méfénamique, diclofénac, chlorambucil
A61K 31/215 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides carboxyliques
A61K 31/351 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à six chaînons avec un oxygène comme seul hétéro-atome d'un cycle non condensés avec un autre cycle
A61K 31/495 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec deux azote comme seuls hétéro-atomes d'un cycle, p. ex. pipérazine
A61P 11/00 - Médicaments pour le traitement des troubles du système respiratoire
A61P 19/04 - Médicaments pour le traitement des troubles du squelette des troubles non-spécifiques du tissu conjonctif
C07K 16/40 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre des enzymes
An embodiment includes a wound dressing comprising: a shape memory polymer (SMP) foam, including open cells, having first and second states; and a hydrogel (HG) included within the cells; wherein (a) in a first position a composite, including the SMP foam and the HG, is configured to be located proximate a hemorrhagic tissue with the SMP foam in the first state; (b) in a second position the composite is configured to be expanded to the second state against the hemorrhagic tissue when the SMP foam is plasticized at 37° C. depressing a glass transition temperature (Tg) of the SMP foam to below 25° C. Other embodiments are described herein.
A61L 15/18 - Bandages, pansements ou garnitures absorbant les fluides physiologiques tels que l'urine, le sang, p. ex. serviettes hygiéniques, tampons contenant des matériaux inorganiques
A61L 15/26 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carboneLeurs dérivés
A61L 15/42 - Utilisation de matériaux caractérisés par leur fonction ou leurs propriétés physiques
A61L 15/46 - Désodorisants ou produits pour neutraliser les mauvaises odeurs, p. ex. pour inhiber la formation d'ammoniac ou la multiplication de bactéries
A61L 24/00 - Adhésifs ou ciments chirurgicauxAdhésifs pour dispositifs de colostomie
A microfluidic device includes a microfluidic channel formed in the microfluidic device and defined by a floor and a ceiling positioned vertically above the floor, wherein the microfluidic channel includes at least one fluid inlet configured to receive a fluid flow and at least one fluid outlet, and wherein at least one of the ceiling and the floor of the microfluidic channel is sloped relative to a horizontal plane.
B81C 1/00 - Fabrication ou traitement de dispositifs ou de systèmes dans ou sur un substrat
C08F 2/48 - Polymérisation amorcée par énergie ondulatoire ou par rayonnement corpusculaire par la lumière ultraviolette ou visible
G03F 7/00 - Production par voie photomécanique, p. ex. photolithographique, de surfaces texturées, p. ex. surfaces impriméesMatériaux à cet effet, p. ex. comportant des photoréservesAppareillages spécialement adaptés à cet effet
An embodiment of the invention includes an expandable implant to endovascularly embolize an anatomical void or malformation, such as an aneurysm. An embodiment is comprised of a chain or linked sequence of expandable polymer foam elements. Another embodiment includes an elongated length of expandable polymer foam coupled to a backbone. Another embodiment includes a system for endovascular delivery of an expandable implant (e.g., shape memory polymer) to embolize an aneurysm. The system may include a microcatheter, a lumen-reducing collar coupled to the distal tip of the microcatheter, a flexible pushing element detachably coupled to an expandable implant, and a flexible tubular sheath inside of which the compressed implant and pushing element are pre-loaded. Other embodiments are described herein.
A61B 17/12 - Instruments, dispositifs ou procédés chirurgicaux pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p. ex. les vaisseaux sanguins ou le cordon ombilical
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
An embodiment includes a platform shape memory polymer system. Such an embodiment exhibits a blend of tunable, high performance mechanical attributes in combination with advanced processing capabilities and good biocompatibility. A post-polymerization crosslinking synthetic approach is employed that combines polyurethane and thiol-ene synthetic processes. Other embodiments are described herein.
An embodiment includes a process for treating an abdominal aortic aneurysm (AAA) endoleak with a shape memory polymer (SMP) foam device. First, a bifurcated stent graft is placed within the aneurysm while a micro guidewire is positioned within the aneurysm for future catheter access. Second, after placing the iliac graft extension, a catheter is introduced over wire to deliver embolic foams. Third, embolic foams expand and conform to the aneurysm wall. Fourth, embolic foams create a stable thrombus to prevent endoleak formation by isolating peripheral vessels from the aneurysm volume.
A61L 31/14 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
A61B 17/12 - Instruments, dispositifs ou procédés chirurgicaux pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p. ex. les vaisseaux sanguins ou le cordon ombilical
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
A61F 2/82 - Dispositifs maintenant le passage ou évitant l’affaissement de structures tubulaires du corps, p. ex. stents
A61F 2/89 - Stents ayant une forme caractérisée par des éléments filiformesStents ayant une forme caractérisée par une structure de type filet ou de type à mailles les éléments filiformes comprenant au moins deux anneaux adjacents reliés de manière flexible par des éléments séparés
A61F 2/945 - Stents conservant leur forme, c.-à-d. non déformables, après mise en place à l’endroit voulu durcissables, p. ex. stents formés in situ
A61F 2/954 - Instruments spécialement adaptés pour insérer ou retirer les stents ou les endoprothèses déployables couvertes pour insérer les stents ou les endoprothèses déployables couvertes dans une bifurcation
A61L 31/06 - Matériaux macromoléculaires obtenus autrement que par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone
A61L 31/18 - Matériaux au moins partiellement opaques aux rayons X ou au laser
11.
SHAPE-MEMORY POLYMER FOAM DEVICE FOR TREATING ANEURYSMS
A system for treating an aneurysm in a blood vessel or vein, wherein the aneurysm has a dome, an interior, and a neck. The system includes a shape memory polymer foam in the interior of the aneurysm between the dome and the neck. The shape memory polymer foam has pores that include a first multiplicity of pores having a first pore size and a second multiplicity of pores having a second pore size. The second pore size is larger than said first pore size. The first multiplicity of pores are located in the neck of the aneurysm. The second multiplicity of pores are located in the dome of the aneurysm.
A61B 17/12 - Instruments, dispositifs ou procédés chirurgicaux pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p. ex. les vaisseaux sanguins ou le cordon ombilical
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
A device for a tissue channel includes a device frame, a shape memory polymer foam segment coupled to the device frame, and an attachment structure coupled to the device frame. The device frame includes a proximal structure, a distal structure, and an intermediate structure coupled to the proximal structure and the distal structure. The proximal structure is configured to collapse to fit into a delivery structure and expand to block migration of the proximal structure. The distal structure is configured to collapse to fit into the delivery structure and expand to block migration of the distal structure. The intermediate structure is configured to fit in the tissue channel upon device deployment. The shape memory polymer foam segment is configured to compress to fit into the delivery structure and occlude the channel. The attachment structure is configured to attach and detach the device from a delivery guide.
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
41 - Educational services, namely, providing courses of instruction at the college level; entertainment services, namely, organizing and conducting lectures; providing news and information in the field of academics
Disclosed is a new variety of Prunus persica named ‘Flat Delight Three’. This new variety, which requires approximately 350 chilling units of dormancy, is considered to be a peach tree of early season maturity, which produces subacid, white-fleshed flat (pantao) fruit that are firm, with the skin covered on 50-80% of its surface with a dark pink to dark maroon blush over a light yellow ground color, and suitable for both local and long-distance shipping.
A method of removing pollutants from flue gas includes cooling the flue gas to remove condensed water. The flue gas is then compressed and dehydrated. The dehydrated flue gas is chilled to separate pollutants.
B01D 53/02 - Séparation de gaz ou de vapeursRécupération de vapeurs de solvants volatils dans les gazÉpuration chimique ou biologique des gaz résiduaires, p. ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par adsorption, p. ex. chromatographie préparatoire en phase gazeuse
B01D 53/14 - Séparation de gaz ou de vapeursRécupération de vapeurs de solvants volatils dans les gazÉpuration chimique ou biologique des gaz résiduaires, p. ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par absorption
Disclosed herein are solid-liquid composites including a crosslinked polymer network having a plurality of inclusions dispersed therein. The inclusions can be regularly spaced apart within the composite. The volume and composition of the inclusions can be controlled to give composites having a variety of different mechanical properties. The composites can be used as surgical phantoms, including cerebrovascular surgical phantoms.
An instrumented blanket includes an insulative material and a temperature control structure integrated with the insulative material. The heating structure is configured to produce a heat or a cooling output in response to an input signal. The temperature-control blanket further includes an optical sensor including an optical fiber integrated with the insulative material along the heating structure. The optical sensor is configured to detect a change in an optical property measured from a plurality of intervals along a length of the optical fiber. The change in the optical property is indicative of a temperature of the temperature-control blanket at a respective interval of the plurality of intervals.
G21C 1/03 - Réacteurs de fission rapides, c.-à-d. réacteurs n'utilisant pas de modérateur refroidis par un réfrigérant non nécessairement pressurisé, p. ex. réacteurs du type piscine
G01K 11/32 - Mesure de la température basée sur les variations physiques ou chimiques, n'entrant pas dans les groupes , , ou utilisant des changements dans la transmittance, la diffusion ou la luminescence dans les fibres optiques
G21C 3/24 - Éléments combustibles avec un matériau fissile ou surrégénérateur sous forme fluide à l'intérieur d'une enveloppe non active
B01F 23/23 - Mélange de gaz avec des liquides en introduisant des gaz dans des milieux liquides, p. ex. pour produire des liquides aérés
18.
SYSTEMS AND METHODS FOR DISCOVERY AND PREDICTING PHENOTYPES
An example method of predicting a phenotype of interest of a subject includes generating apluralityofbiomarkers; selectingasubsetofbiomarkersfromthepluralityofbiomarkers;anddeterminin garelationshipbetweenthesubsetofbiomarkersandthephenotypeofinterest;receivingsample biomarkers;where thesample biomarkerscomprise oneor more measurementsofthesubject;andpredictingthephenotypeofinterestofthesubjectbasedonthesampleb iomarkers and the relationship between the subsetof biomarkers and the phenotype of interest.
Provided herein are nanoengineered biomaterial inks used to 3D print a biocompatible, flexible electronic device, for example, a hydrogel constructs a biocompatible, flexible electronic device or 3D printed wearable electronic devices. The biocompatible, flexible electronic device may be a crosslinked gelatin-SH-2D-MoS2 nanoassembly. Also provided are methods for nanoengineering a biomaterial ink and for determining a treatment for a subject in need thereof utilizing the biocompatible, flexible electronic device.
B01J 13/00 - Chimie des colloïdes, p. ex. production de substances colloïdales ou de leurs solutions, non prévue ailleursFabrication de microcapsules ou de microbilles
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/11 - Mesure du mouvement du corps entier ou de parties de celui-ci, p. ex. tremblement de la tête ou des mains ou mobilité d'un membre
The present disclosure provides compositions and methods for increasing mitochondrial function or decreasing cellular oxidative stress. The present disclosure further provides nanomaterial structures comprising high atomic vacancy concentrations. Aspects of the disclosure further relate to methods for treating diseases or disorders associated with decreased mitochondrial function or increased cellular oxidative stress.
A61K 33/00 - Préparations médicinales contenant des ingrédients actifs inorganiques
A61K 33/04 - Soufre, sélénium ou tellureLeurs composés
A61K 47/52 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé inorganique, p. ex. un ion inorganique complexé avec l’ingrédient actif
A bioreactor device may include a housing assembly having a body defining a bioreactor cavity with an opening, a lid to be received by the opening and including rack openings, and a port coupled to the bioreactor cavity. The bioreactor device may also include racks respectively received by the rack openings. Each of the racks may include a vertical arm, vertically spaced supports coupled to the vertical arm, and substrates respectively carried by the vertically spaced supports, each substrate having culture media thereon. The bioreactor device may also include a control unit coupled to the port and configured to selectively supply culture medium to the bioreactor cavity based upon a characteristic within the bioreactor cavity.
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12M 1/06 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens d'introduction de gaz avec agitateur, p. ex. avec agitateur à turbine
C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus
B01F 101/22 - Mélange d'ingrédients pour compositions pharmaceutiques ou médicales
22.
SYSTEMS AND METHODS FOR DETECTING AND PREDICTING PHENOTYPIC MEASUREMENTS AND PHENOTYPES
An example system for predicting a phenotypic measurement includes a remote sensing platform comprising a remote sensor configured to capture image data, where the image data comprises a plurality of temporally-spaced images of a plant; and a computing device operably coupled to the remote sensing platform, where the computing device includes at least one processor and memory, the memory having computer-executable instructions stored thereon that, when executed by the at least one processor, cause the at least one processor to: input the image data into a prediction model; and determine, using the prediction model, a phenotypic measurement.
A01G 7/06 - Traitement des arbres ou des plantes en cours de croissance, p. ex. pour prévenir la décomposition du bois, pour teinter les fleurs ou le bois, pour prolonger la vie des plantes
G01N 21/84 - Systèmes spécialement adaptés à des applications particulières
G01N 33/00 - Recherche ou analyse des matériaux par des méthodes spécifiques non couvertes par les groupes
An instrumented blanket includes an insulative material and a temperature control structure integrated with the insulative material. The heating structure is configured to produce a heat or a cooling output in response to an input signal. The temperature-control blanket further includes an optical sensor including an optical fiber integrated with the insulative material along the heating structure. The optical sensor is configured to detect a change in an optical property measured from a plurality of intervals along a length of the optical fiber. The change in the optical property is indicative of a temperature of the temperature-control blanket at a respective interval of the plurality of intervals.
G01K 11/3206 - Mesure de la température basée sur les variations physiques ou chimiques, n'entrant pas dans les groupes , , ou utilisant des changements dans la transmittance, la diffusion ou la luminescence dans les fibres optiques en des endroits distincts de la fibre, p. ex. utilisant la diffusion de Bragg
G01K 7/02 - Mesure de la température basée sur l'utilisation d'éléments électriques ou magnétiques directement sensibles à la chaleur utilisant des éléments thermo-électriques, p. ex. des thermocouples
24.
SYSTEMS AND METHODS FOR DETECTING AND PREDICTING PHENOTYPIC MEASUREMENTS AND PHENOTYPES
An example system for predicting a phenotypic measurement includes a remote sensing platform comprising a remote sensor configured to capture image data, where the image data comprises a plurality of temporally-spaced images of a plant; and a computing device operably coupled to the remote sensing platform, where the computing device includes at least one processor and memory, the memory having computer-executable instructions stored thereon that, when executed by the at least one processor, cause the at least one processor to: input the image data into a prediction model; and determine, using the prediction model, a phenotypic measurement.
G06V 10/764 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant la classification, p. ex. des objets vidéo
An example method of predicting a phenotype of interest of a subject includes generating a plurality of biomarkers; selecting a subset of biomarkers from the plurality of biomarkers; and determining a relationship between the subset of biomarkers and the phenotype of interest; receiving sample biomarkers; where the sample biomarkers comprise one or more measurements of the subject; and predicting the phenotype of interest of the subject based on the sample biomarkers and the relationship between the subset of biomarkers and the phenotype of interest.
G16B 5/00 - TIC spécialement adaptées à la modélisation ou aux simulations dans la biologie des systèmes, p. ex. réseaux de régulation génétique, réseaux d’interaction entre protéines ou réseaux métaboliques
G16B 25/10 - Profilage de l’expression de gènes ou de protéinesEstimation ou normalisation de ratio d’expression
G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p. ex. pour des analyses d’échantillon de patient
G16H 20/10 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p. ex. pour s’assurer de l’administration correcte aux patients
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
26.
ELECTROCHEMICAL STORAGE INCORPORATING SIZE- AND MORPHOLOGY-CONTROLLED METASTABLE VANADIUM PENTOXIDE AS A CATHODE MATERIAL FOR ION BATTERIES
The Li-ion paradigm of battery technology is fundamentally constrained by the monovalency of the Li-ion. A straightforward solution is to transition to multivalent ion chemistries, with Mg2+ the most obvious candidate due to considerations of size and mass. Despite early interest, the realization of Mg batteries has faced myriad obstacles, including a sparse selection of cathode materials demonstrating the ability to reversibly insert divalent ions. Disclosed herein is evidence of reversible topochemical and electrochemical insertion of Mg2+ into a metastable one-dimensional polymorph of V2O5. Not only does ζ-V2O5 represent a rare addition to the pantheon of functional Mg battery cathode materials, but is also distinctive in exhibiting a combination of high stability, high specific capacity due to ion insertion, and moderately high operating voltage.
A wearable biosensor for real-time quantification of a biomarker in a biofluid includes at least one functional module. The functional module includes an iontophoresis induction module, a microfluidic layer, a plurality of multimodal biosensors, and a paperfluidic layer.
A61B 5/1477 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang en utilisant des procédés chimiques ou électrochimiques, p. ex. par des moyens polarographiques non invasifs
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
28.
ENVIRONMENTAL BIOSPECIMEN RECOVERY AFTER IN-DROPLET GEL ENCAPSULATION
In an embodiment. the present disclosure pertains to environmental biospecimen recovery after in-droplet gel encapsulation (eBRIDGE) platforms for co-culturing multiple microorganisms in gel microspheres and then transferring single-cell-derived clonal populations from within the gel microspheres into separate water-in-oil emulsion droplets for further processing and analysis. In some embodiments. the gel-encapsulated bacteria are released by lysing the gel matrix using an enzyme. The methods of the present disclosure provide a single workflow that goes from environmental microbial harvesting and amplification to functional interrogation of their characteristics.
G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
C12N 11/04 - Enzymes ou cellules microbiennes immobilisées sur ou dans un support organique piégées à l’intérieur du support, p. ex. dans un gel ou dans des fibres creuses
29.
SMART SINGLE-DOMAIN INTRABODIES WITH PRECISION SWITCHES FOR BIOMEDICAL APPLICATIONS
The present disclosure provides intrabody compositions comprising i) an intrabody and ii) one or more inserts. The disclosure also provides methods for activating and deactivating intracellular and extracellular interactions utilizing the compositions, for instance via chemical and/or light.
C07K 14/71 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire pour des facteurs de croissanceRécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire pour des régulateurs de croissance
A61K 47/65 - Séquences de liaison, liants ou bras-espaceurs peptidiques, p. ex. séquences de liaison peptidiques vulnérable aux protéases
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
C07K 16/10 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus de virus à ARN
30.
PHYSIOLOGICALLY RELEVANT PUMPS AND ASSOCIATED SYSTEMS AND METHODS
A physiologically relevant pump includes a support frame, a flexible bladder sealingly coupled to the support frame, a mechanical drive coupled to at least one of the support frame, and a pump motor coupled to the support frame and the mechanical drive and configured, in response to receiving a control signal, to displace, through the mechanical drive, a first end of the flexible bladder relative to a second end of the flexible bladder to alter an internal volume of the flexible bladder whereby a desired fluid pressure in an internal chamber of the flexible bladder is achieved.
G05D 7/06 - Commande de débits caractérisée par l'utilisation de moyens électriques
G16H 50/50 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour la simulation ou la modélisation des troubles médicaux
In an embodiment, the present disclosure pertains to a method of deposition of nanostructures with engineered patterns. In an additional embodiment, the present disclosure pertains to a method of preparing colloidal suspensions of hybrid nanoparticle systems (HNMS). In a further embodiment, the present disclosure pertains to a method of making a cellulose nanocrystal (CNC)-bonded carbon nanotube carbon fiber reinforced polymer (CNT-CFRP) hybrid composite. In another embodiment, the present disclosure pertains to a method of making a cellulose nanocrystal (CNC)-bonded graphene nanoplatelets (GNP) carbon fiber reinforced polymer (GNP-CFRP) hybrid composite. In a further embodiment, the present disclosure pertains to a method of making a hybrid cellulose nanocrystal (CNC)-graphene nanoplatelet(boron nitride nanobarb) (GNP-(BNNB))-carbon fiber (CF)Zpolyether ether ketone (PEEK) using spray-coating.
The present invention is related to the fields of bioplastics. In particular, a strain of photosynthetic cyanobacteria (i.e. blue-green algae) having a high growth rate was engineered to overexpress limonene synthase. These engineered cyanobacteria improve auto-sedimentation for biomass harvest and provide for plastic bioremediation capture. Further, machine-learning methods are provided for improving some of the aspects of cultivating cyanobacteria including, but not limited to, assessing real-time light availability and predicting real-time algae growth rates to increase a cyanobacteria biomass.
A wearable biosensing system includes a case, a contact carriage, a biosensor, and a contact pressure management unit. The case is adapted to be fixed to a skin surface of a user. The contact carriage is mounted for movement relative to the case into contact with the skin surface of the user to apply a contact pressure to the skin surface of the user. The biosensor is configured to measure physiological signals of the user. The contact pressure management includes at least one pressure sensor configured to output pressure data.
A61B 5/0205 - Évaluation simultanée de l'état cardio-vasculaire et de l'état d'autres parties du corps, p. ex. de l'état cardiaque et respiratoire
A61B 5/0295 - Mesure du débit sanguin utilisant la pléthysmographie, c.-à-d. par mesure des variations du volume d'une partie du corps induites par la circulation du sang qui traverse cette partie, p. ex. pléthysmographie par impédance
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
41 - Educational services, namely, providing courses of instruction at the college level; entertainment services, namely, organizing and conducting college sports events, lectures, college graduation ceremonies; providing news and information in the field of sports and academics; providing a website featuring blogs and non-downloadable publications in the nature of articles and information in the fields of academics, alumni achievements, athletics, research, service, and student life
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
41 - Educational services, namely, providing courses of instruction at the college level; entertainment services, namely, organizing and conducting college sports events, lectures, college graduation ceremonies; providing news and information in the field of sports and academics; providing a website featuring blogs and non-downloadable publications in the nature of articles and information in the fields of academics, alumni achievements, athletics, research, service, and student life
36.
CEASELESS INDUSTRY FEARLESS INVESTIGATION UNFETTERED THOUGHT UNSELFISH SERVICE EAST TEXAS A&M UNIVERSITY 1889
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Educational services, namely, providing courses of instruction at the college level; entertainment services, namely, organizing and conducting college graduation ceremonies.
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
41 - Educational services, namely, providing courses of instruction at the college level; entertainment services, namely, organizing and conducting college sports events, lectures, college graduation ceremonies; providing news and information in the field of sports and academics; providing a website featuring blogs and non-downloadable publications in the nature of articles and information in the fields of academics, alumni achievements, athletics, research, service, and student life
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Educational services, namely, providing courses of instruction at the college level; entertainment services, namely, organizing and conducting college sports events, lectures, college graduation ceremonies; providing news and information in the field of sports and academics; providing a website featuring blogs and non-downloadable publications in the nature of articles and information in the fields of academics, alumni achievements, athletics, research, service, and student life.
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Educational services, namely, providing courses of instruction at the college level; entertainment services, namely, organizing and conducting college sports events, lectures, college graduation ceremonies; providing news and information in the field of sports and academics; providing a website featuring blogs and non-downloadable publications in the nature of articles and information in the fields of academics, alumni achievements, athletics, research, service, and student life
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
41 - Educational services, namely, providing courses of instruction at the college level; entertainment services, namely, organizing and conducting lectures; providing news and information in the field of academics
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Educational services, namely, providing courses of instruction at the college level; entertainment services, namely, organizing and conducting college sports events, lectures, college graduation ceremonies; providing news and information in the field of sports and academics; providing a website featuring blogs and non-downloadable publications in the nature of articles and information in the fields of academics, alumni achievements, athletics, research, service, and student life.
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Educational services, namely, providing courses of instruction at the college level; entertainment services, namely, organizing and conducting college sports events, lectures, college graduation ceremonies; providing news and information in the field of sports and academics; providing a website featuring blogs and non-downloadable publications in the nature of articles and information in the fields of academics, alumni achievements, athletics, research, service, and student life.
43.
SYNTHETIC PROTEIN SCAFFOLDS TO TARGET AND REMOVE BACTERIAL VIRULENCE PILI
Synthetic bacterial phage maturation (Mat) protein scaffolds, compositions, and methods of use to decrease bacterial virulence, treat and prevent bacterial infections, and lower the incidence of bacterial gene transfers to combat the spread of treatment-resistant bacterial strains. Scaffolds include at least a portion of an apical domain of a Mat protein and can decrease type IV pili (T4P) attachment for reduction of bacterial virulence.
A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes
C07K 14/21 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries provenant de Pseudomonadaceae (F)
C12N 15/62 - Séquences d'ADN codant pour des protéines de fusion
C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteursVecteurs Utilisation d'hôtes pour ceux-ciRégulation de l'expression
C12N 15/79 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes
An apparatus for surgical lighting is disclosed. The apparatus includes a light emitting element formed with a light source encapsulated within an outer layer. The outer layer includes a biocompatible material. A power supply is coupled to the light source. The apparatus includes an actuating mechanism that controls power from the power supply to the light source to emit light along a surgical area. The light emitting element provides enhanced illumination and other surgical advantages.
A61B 90/30 - Dispositifs pour éclairer une zone chirurgicale, les dispositifs ayant une corrélation avec d’autres dispositifs chirurgicaux ou avec une intervention chirurgicale
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
F21S 2/00 - Systèmes de dispositifs d'éclairage non prévus dans les groupes principaux ou , p. ex. à construction modulaire
A passive infrared (PIR) sensor system, includes a PIR sensor configured to produce an output signal in response to receiving infrared (IR) radiation, an electronic shutter positionable in a field of view (FOV) of the PIR sensor, wherein the electronic shutter includes a liquid crystal (LC) material, wherein the electronic shutter includes a first state providing a first transmissivity of IR radiation through the electronic shutter and a second state providing a second transmissivity of IR radiation through the electronic shutter that is less than the first transmissivity, and a shutter actuator configured to apply an actuation signal to the electronic shutter to actuate the electronic shutter between the first state and the second state.
G01J 5/34 - Pyrométrie des radiations, p. ex. thermométrie infrarouge ou optique en utilisant des détecteurs électriques de radiations en utilisant des condensateurs, p. ex. des condensateurs pyroélectriques
Described herein are compounds and methods for the treatment of coronavirus infection. The compounds can function as an inhibitor of the main protease (Mpro) of coronaviruses. The compounds can include diphenylmethyl piperazine derivatives, diphenylmethyl piperidine derivatives, diphenylmethylidene piperidine derivatives, tricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen derivatives, tricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,9,12,14-heptaen derivatives, 6,11-dihydrobenzo[c][1]benzoxepin derivatives, 6,11-dihydrobenzo[c][1]benzothiepin derivatives, 5,5-dioxo-6,11-dihydrobenzo[c][1]benzothiepin derivatives, and 6-oxo-5,11-dihydrobenzo[c][1]benzazepin derivatives, as well as pharmaceutically acceptable salts, hydrates, and prodrugs thereof.
A61K 31/444 - Pyridines non condenséesLeurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p. ex. amrinone
A61K 31/4545 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pipampérone, anabasine
A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p. ex. rifampine, thiothixène ou sparfloxacine
A61K 31/4995 - Pyrazines ou pipérazines formant une partie de systèmes cycliques pontés
A61K 31/55 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
C07D 409/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 409/14 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre comme uniques hétéro-atomes du cycle contenant au moins trois hétérocycles
C07D 519/00 - Composés hétérocycliques contenant plusieurs systèmes de plusieurs hétérocycles déterminants condensés entre eux ou condensés avec un système carbocyclique commun non prévus dans les groupes ou
The current disclosure provides polypeptides and peptides comprising SEQ ID NO: 1. Antibodies or antigen binding fragments thereof specifically bind to a polypeptide comprising SEQ ID NO: 1 or peptide fragments thereof (e.g., SEQ ID NOs: 2 and/or 3) are also provided. Accordingly, the current disclosure provides polypeptides and peptides comprising ant one of SEQ ID NOs: 1-6 or fragments thereof. The antibodies or antigen binding fragments thereof can be monoclonal antibodies (Mab), chimeric antibodies, single chain antibodies, single chain fragment variable (scFv) antibodies, or fragment antigen-binding (Fab fragment). The antibodies or antigen binding fragments thereof can be labeled with an enzyme, a radioisotope, a fluorescent label, or a bioluminescent label and/or used in diagnostic assays. Diagnostic assays and vaccines using the disclosed polypeptides or fragments thereof are also provided.
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
48.
COMPOSITIONS AND METHODS FOR GENOME EDITING ACROSS GRAFT-JUNCTIONS
Provided are compositions and methods for modifying a plant genome. Methods and compositions are also provided for delivering genome editing components across graft junctions and generating genome modified plants in the presence of a selection agent without integration of a selectable marker gene into the genome. Recombinant DNA constructs for modifying a plant genome and plants comprising the same are further provided.
Toyota Motor Engineering & Manufacturing North America, Inc. (USA)
Toyota Jidosha Kabushiki Kaisha (Japon)
The Texas A&M University System (USA)
Inventeur(s)
Ponce Valderrama, Victor
Marjuban, Shaik Merkatur Hakim
Castaneda-Lopez, Homero
Eich, Heather M.
Tarr, Walter D.
Abrégé
A corrosion monitoring system includes a processor, and a memory in communication with the processor and having a control module, a potentiostat, coupled to a clamp with a first plate and a second plate. The control module includes instructions that, when executed by the processor, cause the processor to control the potentiostat to apply a voltage to the first plate and the second plate during an EIS test of a coating on a metal substrate disposed between the first plate and the second plate. The corrosion monitoring system also monitors or detects a change in at least one of a phase angle and an impedance of the applied voltage, and identifies a change in corrosion activation at the substrate for any coating system based, at least in part, on the change in the at least one of the phase angle and the impedance.
A biosensor for in situ continuous monitoring of molecular biomarkers includes a flexible organic or inorganic layer, and a biorecognition element microarray placed on the organic or inorganic layer. In some aspects, the flexible layer is placed upon a disk that may be made of, for example, one or more of poly dimethylsiloxane (PDMS), silicone, polyurethane, polymers, and hydrogels. The organic or inorganic layer enables the immobilization of biorecognition elements, such as polystyrene (PS) film comprises functional groups from Gamma irradiation to increase biorecognition element binding. The biorecognition elements may include, for example, one or more of an antibody, aptamer, peptide, molecularly imprinted polymers, nucleic acid.
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
B81C 1/00 - Fabrication ou traitement de dispositifs ou de systèmes dans ou sur un substrat
C07K 16/24 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des cytokines, des lymphokines ou des interférons
51.
SYSTEMS AND METHODS FOR IDENTIFYING ONE OR MORE SUBSTANCES USING MICRO-PLASMA INDUCED BREAKDOWN SPECTROSCOPY
A system for identifying one or more substances in a liquid sample using micro¬ plasma induced breakdown spectroscopy (MIBS) includes a system controller including a processor and memory encoded with instructions that, when executed by the processor, cause the processer to activate one or more pulse generators to apply one or more electrical pulses to a plasma electrode whereby a plasma discharge is generated in the liquid sample when the liquid sample is received in the plasma receptacle, wherein the voltage of each of the one or more electrical pulses applied to the plasma electrode is between 13 kilovolts (kV) and 40 kV, and activate an optical detector to identify the one or more substances in the liquid sample based on an optical signal from the plasma discharge that is collected by an optical collector.
G01N 21/73 - Systèmes dans lesquels le matériau analysé est excité de façon à ce qu'il émette de la lumière ou qu'il produise un changement de la longueur d'onde de la lumière incidente excité thermiquement en utilisant des brûleurs ou torches à plasma
G01N 21/75 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé
G01N 21/85 - Analyse des fluides ou solides granulés en mouvement
G01N 21/71 - Systèmes dans lesquels le matériau analysé est excité de façon à ce qu'il émette de la lumière ou qu'il produise un changement de la longueur d'onde de la lumière incidente excité thermiquement
H05H 1/16 - Dispositions pour confiner le plasma au moyen de champs électriques ou magnétiquesDispositions pour chauffer le plasma utilisant des champs électriques et magnétiques
H05H 1/18 - Dispositions pour confiner le plasma au moyen de champs électriques ou magnétiquesDispositions pour chauffer le plasma utilisant des champs électriques et magnétiques dans lesquels les champs oscillent à très haute fréquence, p. ex. dans la bande des micro-ondes
A61K 31/4406 - Pyridines non condenséesLeurs dérivés hydrogénés substituées uniquement en position 3, p. ex. zimeldine
A61K 31/4439 - Pyridines non condenséesLeurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p. ex. oméprazole
A61K 31/4545 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pipampérone, anabasine
A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p. ex. rifampine, thiothixène ou sparfloxacine
A61K 31/4985 - Pyrazines ou pipérazines condensées en ortho ou en péri avec des systèmes hétérocycliques
C07D 417/04 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
C07D 519/00 - Composés hétérocycliques contenant plusieurs systèmes de plusieurs hétérocycles déterminants condensés entre eux ou condensés avec un système carbocyclique commun non prévus dans les groupes ou
53.
COMPOSITIONS AND METHODS FOR GENOME EDITING ACROSS GRAFT-JUNCTIONS
Provided are compositions and methods for modifying a plant genome. Methods and compositions are also provided for delivering genome editing components across graft junctions and generating genome modified plants in the presence of a selection agent without integration of a selectable marker gene into the genome. Recombinant DNA constructs for modifying a plant genome and plants comprising the same are further provided.
C12Q 1/6827 - Tests d’hybridation pour la détection de mutation ou de polymorphisme
C12Q 1/6895 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les plantes, les champignons ou les algues
A01H 4/00 - Reproduction de plantes par des techniques de culture de tissus
Disclosed herein are antisense oligonucleotides that are capable of inducing expression of ubiquitin-protein ligase E3A (UBE3A) from the paternal allele in animal or human neurons. The oligonucleotides target the suppressor of the UBE3A paternal allele by hybridization to SNHG14 long non-coding RNA at the 5′-end of UBE3A-AS, which is downstream of SNORD115-45 snoRNA. Also disclosed are pharmaceutical compositions and methods for treatment of Angelman syndrome.
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
C07H 21/04 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le désoxyribosyle comme radical saccharide
Board of Regents, The University of Texas System (USA)
Inventeur(s)
Haas, Derek
Robison, Jordan
Biegalski, Steven
Head, Timothy
Towell, Rusty
Clarno, Kevin
Petrovic, Bojan
Tsvetkov, Pavel
Scherr, Jonathan
Kimber, Mark
Abrégé
An integral molten salt nuclear reactor includes a drain tank section configured to hold a volume of fuel salt. The integral molten salt nuclear reactor further includes a reactor section configured to receive the volume of fuel salt from the drain tank and cause fission reactions that heats the molten salt. The integral molten salt nuclear reactor further includes a heat exchange section configured to receive a flow of the heated fuel salt from the reactor section and remove heat therefrom.
G21C 1/32 - Réacteurs du type intégré, c.-à-d. réacteurs dans lesquels des parties associées de façon fonctionnelle avec le réacteur, mais non essentielles à la réaction, p. ex. des échangeurs de chaleur, sont disposées à l'intérieur de l'enveloppe avec le cœur
G21C 7/30 - Commande de la réaction nucléaire par déplacement du combustible du réacteur ou des éléments combustibles
56.
CORN ENDOTYPE-DERIVED POLYPEPTIDES CAPABLE OF METABOLIZING FUMONISIN
Polynucleotides and polypeptides conferring the ability to detoxify or metabolize the mycotoxin fumonisin are provided, as are constructs, compositions, and plants comprising the polynucleotides and polypeptides. Also provided are plants having the ability to detoxify fumonisin, methods of conferring fumonisin detoxification, methods of controlling fumonisin contamination, and kits and methods for identification of plants having the ability to detoxify fumonisin.
C12Q 1/6895 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les plantes, les champignons ou les algues
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (USA)
Inventeur(s)
Haas, Derek
Robison, Jordan
Biegalski, Steven
Head, Timothy
Towell, Rusty
Clarno, Kevin
Petrovic, Bojan
Tsvetkov, Pavel
Scherr, Jonathan
Kimber, Mark
Abrégé
An integral molten salt nuclear reactor includes a drain tank section configured to hold a volume of fuel salt. The integral molten salt nuclear reactor further includes a reactor section configured to receive the volume of fuel salt from the drain tank and cause fission reactions that heats the molten salt. The integral molten salt nuclear reactor further includes a heat exchange section configured to receive a flow of the heated fuel salt from the reactor section and remove heat therefrom.
G01C 3/30 - Mesure des distances dans la ligne de viséeTélémètres optiques en utilisant un triangle parallactique ayant des angles fixes et une base de longueur variable, se trouvant sur l'objet, au voisinage de celui-ci, ou constitué par l'objet lui-même avec des dispositions permettant la réduction de la distance dans le plan horizontal avec adaptation à la mesure de la hauteur d'un objet, p. ex. tachéomètres
G21C 3/54 - Sels fondus, compositions oxydes ou hydroxydes
G21C 7/30 - Commande de la réaction nucléaire par déplacement du combustible du réacteur ou des éléments combustibles
G21C 9/00 - Dispositions pour la protection d'urgence structurellement associées avec le réacteur
G21C 9/02 - Moyens pour effectuer une réduction très rapide du facteur de réactivité dans des conditions défectueuses, p. ex. fusible pour réacteur
Embodiments of the disclosure include compositions comprising peptides with an N-terminal capping motif or with the combination of an N-terminal capping motif and a C-terminal capping motif, and methods for synthesizing the peptides. The capping motifs can impart helicity to peptides that otherwise do not exhibit helicity. The helix capping motifs are conformationally rigid, improve peptide serum stability, and increase cell permeability of peptides.
Polynucleotides and polypeptides conferring the ability to detoxify or metabolize the mycotoxin fumonisin are provided, as are constructs, compositions, and plants comprising the polynucleotides and polypeptides. Also provided are plants having the ability to detoxify fumonisin, methods of conferring fumonisin detoxification, methods of controlling fumonisin contamination, and kits and methods for identification of plants having the ability to detoxify fumonisin.
The present disclosure pertains to a circulating tumor cell (CTC) microfluidic platform that is used for the detection of CTCs, enumeration of CTCs in a sample, characterization of biophysical properties, CTC cell size, CTC cell membrane deformability, stresses on CTC cell membranes, adhesion stress on CTC cells, normal stress of CTC cells, or combinations thereof.
G01B 11/16 - Dispositions pour la mesure caractérisées par l'utilisation de techniques optiques pour mesurer la déformation dans un solide, p. ex. indicateur optique de déformation
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
Embodiments of the disclosure include compositions comprising peptides with C-terminal capping motifs, and methods for making the compositions. The capping motifs impart helicity to C-termini of peptides that otherwise do not exhibit helicity. The helix capping motifs are conformationally rigid, stable in serum, and increase cell permeability of peptides.
Board of Regents, The University of Texas System (USA)
Inventeur(s)
Kelly, Ryan
Biegalski, Steven
Brownfield, Ryan
Farrar, Kraig
Gates, Tyler
Haas, Derek
Scherr, Jonathan
Shoemate, Jack
Tsvetkov, Pavel
Abrégé
A method and system for calibrating nuclear instrumentation of a reactor is disclosed. The system comprises a reactor configured to operate at a low power level and an external heater configured to heat the reactor to its operating temperature and maintain the reactor in a critical state. The reactor maintains its temperature at a steady state by repeating steps of reducing the heater's power and increasing the reactor's power by changing one or more reactivity settings, wherein the reduced heater's power is compensated by using the increased power generated by the reactor itself. The nuclear instrumentation is configured to measure the reactor's output power and compare it with the calculated reactor's power. Based on the discrepancy between the calculated power and the measured power exceeds a threshold; and the nuclear instrumentation is appropriately calibrated by adjusting one or more settings.
Disclosed are RNA inhibitors, such as small interfering RNAs (siRNAs) and short hairpin RNAs (shRNAs) specific for RND3, alternatively referred to as RhoE. Also disclosed are methods of treating subjects by administering RNA inhibitors. Further disclosed are methods of detecting potential modulators of RND3.
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
A61K 31/713 - Acides nucléiques ou oligonucléotides à structure en double-hélice
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
G01N 33/573 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour enzymes ou isoenzymes
64.
INTERDIGITATED ELECTRODE-BASED DROPLET MANIPULATION IN MICROFLUIDIC SYSTEMS
In an embodiment, the present disclosure pertains to a droplet system, apparatus, or fluid sample testing system to accomplish high-precision and high-efficiency droplet manipulation (e.g., greater than 99% platform operation efficiency). In some embodiments, the droplet system, apparatus, or fluid sample testing system includes at least one microfluidic channel or chamber and at least one interdigitated electrode (IDE) that can create a localized electric field below and/or within at least one fluidic channel or chamber. In some embodiments, this allows size-specific and/or size-dependent droplet manipulation.
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (USA)
THE TEXAS A&M UNIVERSITY SYSTEM (USA)
Inventeur(s)
Tatsui, Claudio E.
Bird, Justin E.
Rhines, Laurence D.
North, Robert Y.
Alvarez-Breckenridge, Christopher A.
Bohle, Kihoon
Mansfield, Hunter
Abrégé
A spinal fixation assembly for use with a cervical fixation rod and methods of use thereof. The spinal fixation assembly can comprise a washer comprising a first side and a second side opposing the first side, the first side comprising a first set of teeth arranged longitudinally, the second side comprising a second set of teeth arranged circumferentially and a laminar wing comprising a slot configured to receive a fastener therethrough, wherein the laminar wing extends laterally from the cervical fixation rod when coupled thereto, the laminar wing adjustably coupled to the cervical fixation rod via the washer such that the first set of teeth are configured to allow a longitudinal position of the laminar wing to be adjusted relative to the cervical fixation rod and the second set of teeth are configured to allow an orientation of the laminar wing to be adjusted relative to the cervical fixation rod.
A61B 17/70 - Dispositifs de mise en position ou de stabilisation de la colonne vertébrale, p. ex. stabilisateurs comprenant un liquide de remplissage dans un implant
Methods and compositions for the treatment of Brucella induced diseases and disorders are disclosed herein. In preferred embodiments, the invention relates to a vaccine compositions and methods of vaccinating comprising: a Brucella canis comprising one or more attenuating gene knockouts; and a pharmaceutically acceptable vaccine carrier.
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (USA)
Inventeur(s)
Kelly, Ryan
Haas, Derek
Scherr, Jonathan
Shoemate, Jack
Tsvetkov, Pavel
Biegalski, Steven
Brownfield, Ryan
Farrar, Kraig
Gates, Tyler
Abrégé
A method and system for calibrating nuclear instrumentation of a reactor is disclosed. The system comprises a reactor configured to operate at a low power level and an external heater configured to heat the reactor to its operating temperature and maintain the reactor in a critical state. The reactor maintains its temperature at a steady state by repeating steps of reducing the heater's power and increasing the reactor's power by changing one or more reactivity settings, wherein the reduced heater's power is compensated by using the increased power generated by the reactor itself. The nuclear instrumentation is configured to measure the reactor's output power and compare it with the calculated reactor's power. Based on the discrepancy between the calculated power and the measured power exceeds a threshold; and the nuclear instrumentation is appropriately calibrated by adjusting one or more settings.
A method of producing a lignin composition comprising contacting a lignin obtained from a renewable resource with an aqueous fluid a plurality of times to produce a washed lignin; contacting the washed lignin with an acid under conditions suitable for formation of an acid washed lignin; contacting the acid washed lignin with one or more cellulases to form a pretreated lignin; and fermenting the pretreated lignin to form a crosslinked high molecular weight lignin. A composite material comprising a high molecular weight crosslinked lignin and at least one material selected from the group consisting of carbon fiber, polymers, a precursor for carbon-based materials, nanomaterials, cement, concrete and combinations thereof.
A metal hydride storage system (MHSS) and a method for refueling the MHSS includes obtaining a parameter vector comprising a first state of a metal hydride storage system (MHSS), and a measurable output of the MHSS; sending the parameter vector to a control algorithm, wherein the control algorithm includes a first data structure and a second data structure, wherein the first data structure corresponds to a plurality of critical regions, wherein the second data structure corresponds to a plurality of piecewise affine functions, wherein the affine functions corresponds to a control action; searching the first data structure with the parameter vector; selecting a critical region based on searching the first data structure; selecting, from the second data structure, a piecewise affine function corresponding to the selected critical region; and calculating a control action based on the affine function, where the control action comprises controlling at least one controlled parameter.
Systems and methods for automated separation and recovery of compounds from solution are disclosed herein. In some embodiments, the system can use a pump in fluid/air communication with a chromatography column to dissolve and recover astatine from a solution containing astatine, bismuth, and nitric acid. The system can be in communication with a controller that can automate and/or remotely signal each component of the system to execute the recovery without manual user inputs.
Blood coagulation testing can be performed by measuring, based on video of a blood sample flowing in a microfluidic channel, the time it takes until flow stops due to clotting. In various embodiments, such measurements are enabled by a low-cost testing system that includes a microfluidic cartridge and uses a smartphone or similar device for video acquisition, in conjunction with a lighting module for illuminating the microfluidic channel and a 3D-printed platform for holding and positioning and orienting the cartridge, lighting module, and smartphone in fixed special relation to each other.
Disclosed are example efficient circuits that produce spark discharges for hydrocarbon conversion (or treatment of other mixtures) using a high-voltage rectified DC supply to discharge a capacitor (either internal or external) across a two-electrode gap, optimized to minimize waste energy by operating in a constant current, approximately-constant current, or constant power mode. The circuits may operate off of a standard electrical supply line (e.g. 120 VAC or 240 VAC, 60 Hz, single-phase or multi-phase). The disclosed approach is scalable to any number of discharge gaps while maintaining similar pulse characteristics and electrical efficiency.
C10G 15/08 - Craquage des huiles d'hydrocarbures par des moyens électriques, par des vibrations électromagnétiques ou mécaniques, par des radiations particulaires ou avec des gaz surchauffés dans des arcs électriques par des moyens électriques ou par des vibrations électromagnétiques ou mécaniques
B01J 19/08 - Procédés utilisant l'application directe de l'énergie ondulatoire ou électrique, ou un rayonnement particulaireAppareils à cet usage
73.
MID-INFRARED WAVEGUIDE SENSORS FOR VOLATILE ORGANIC COMPOUNDS
Chalcogenide waveguides with high width-to-height aspect ratios and a smooth exposed surfaces can serve as mid-infrared evanescent-absorption-based sensors for detecting and identifying volatile organic compounds and/or determining their concentration, optionally in real-time. The waveguide sensors may be manufactured using a modified sputtering process in which the sputtering target and waveguide substrate are titled and/or laterally offset relative to each other and the substrate is continuously rotated.
In one aspect, the disclosure relates to a universal method for biomarker extraction and detection from clinical samples using magnetic nanoparticles (MNPs) coupled with a locked aptamer-initiator approach. The MNP bound locked aptamer undergoes a conformational change in the presence of the target biomarker and the unfolded initiator triggers a hybridization chain reaction with a structurally stabilized catalytic trimeric triplex DNAzyme hairpin. Amplicons from the hybridization chain reaction can be incubated with hemin to obtain a stable triplex structure that has horseradish peroxidase-like activity in the presence of H2O2 and a substrate molecule. The intensity of the signal is directly proportional to the amount of biomarker present. Binding one or more reagents on a nanoparticle can be coupled with this approach for use in a microfluidic or paper fluidic platform. In any of these aspects, the assay can detect as low as femtogram amounts of biomarker from the clinical sample.
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
75.
EUKARYOTIC ELONGATION FACTOR-2 KINASE AS A CYTOTOXIC T LYMPHOCYTES BOOSTER
In an embodiment, the present disclosure pertains to a method of reducing cytocidal activity of cells. In some embodiments, the method includes altering eukaryotic elongation factor-2 kinase (eEF-2K) in a subject and inducing a reduction of cytocidal activity of cytotoxic T cells (CTLs) in the subject. In some embodiments, the altering of eEF-2K in the subject can include a decrease of eEF-2K in the subject.
In an embodiment, the present disclosure pertains to a wearable sensor. In some embodiments, the wearable sensor includes a double-sided adhesive layer, a paper microfluidic layer, and an encapsulation layer. In an additional embodiment, the present disclosure pertains to a method of biochemical analysis. In general, the method includes collecting biofluid from a subject via a wearable sensor and quantifying the biofluid. In some embodiments, the wearable sensor includes a double-sided adhesive layer and a paper microfluidic layer having a microfluidic channel in a serpentine configuration. In some embodiments the microfluidic channel includes an inlet to receive the biofluid, an outlet to collect the excess biofluid, and a plurality of plasmonic sensors.
A61B 5/1455 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang en utilisant des capteurs optiques, p. ex. des oxymètres à photométrie spectrale
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
A method and system for decoding low density parity check (LDPC) codes. A method includes performing block parallel processing that initiates processing all non-zero block columns of a plurality (M) of rows of a layer of an LDPC matrix in each clock cycle, where M≤p, and p is a total number of rows in a layer of the LDPC matrix; and updating a P message responsive to determination of a final state for each row of the LDPC matrix. The LDPC matrix includes layers, each comprising a plurality (M) of rows that are processed per clock cycle. Each of the plurality of rows of each of the layers is datawise independent of the rows processed during a previous NP_MAX clock cycles and at least one row in each layer is datawise dependent on a row of an immediately preceding layer, and NP_MAX is greater than one.
H03M 13/11 - Détection d'erreurs ou correction d'erreurs transmises par redondance dans la représentation des données, c.-à-d. mots de code contenant plus de chiffres que les mots source utilisant un codage par blocs, c.-à-d. un nombre prédéterminé de bits de contrôle ajouté à un nombre prédéterminé de bits d'information utilisant plusieurs bits de parité
H03M 13/00 - Codage, décodage ou conversion de code pour détecter ou corriger des erreursHypothèses de base sur la théorie du codageLimites de codageMéthodes d'évaluation de la probabilité d'erreurModèles de canauxSimulation ou test des codes
Method and systems for situational awareness are disclosed. An example method includes receiving a first set of sensor data from a plurality of internal data sources that describes geospatial locations of objects within an airspace. The method also includes receiving event data from an external data source over a network describing publicly available information affecting the airspace. The method also includes receiving a second set of sensor data from another external data source operated by a user that describes the geospatial location of a user-operated object. The method also includes generating object metadata based on the first and second sets of sensor data and the event data. The method also includes streaming at least a subset of the object metadata to the computing device of the user. The object metadata is processed to generate a real-time three-dimensional rendering of the airspace, including the objects and the user-operated object.
A method for reconstructing a three-dimensional (3D) of a sample includes displacing an outer surface of the sample at a desired sample, repeatedly activating an ultraviolet stroboscopic illuminator to produce ultraviolet excitation light at a frequency that is based on the speed of the sample, repeatedly activating a pair of laterally spaced cameras of a stereoscopic imaging unit as the outer surface of the sample is displaced to capture a plurality of 2D images of different sections of the outer surface of the sample, and reconstructing a 3D image of the sample from the plurality of 2D images of the different sections captured by the pair of cameras.
H04N 13/167 - Synchronisation ou commande des signaux d’images
H04N 13/239 - Générateurs de signaux d’images utilisant des caméras à images stéréoscopiques utilisant deux capteurs d’images 2D dont la position relative est égale ou en correspondance à l’intervalle oculaire
H04N 13/254 - Générateurs de signaux d’images utilisant des caméras à images stéréoscopiques en combinaison avec des sources de rayonnement électromagnétique pour l’éclairage du sujet
80.
Amorphous Silicon Oxide, Amorphous Silicon Oxynitride, and Amorphous Silicon Nitride Thin Films and Uses Thereof
BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM (USA)
UT- BATTELLE, LLC (USA)
Inventeur(s)
Varanasi, Venu
Aswath, Pranesh
Maginot, Megen
Lavrik, Nickolay V.
Abrégé
Amorphous SiOx (SiO2), SiONx, silicon nitride (Si3N4), surface treatments are provided, on both metal (titanium) and non-metal surfaces. Amorphous silicon-film surface treatments are shown to enhance osteoblast and osteoblast progenitor cell bioactivity, including biomineral formation and osteogenic gene panel expression, as well as enhanced surface hydroxyapatite (HA) formation. A mineralized tissue interface is provided using the amorphous silicon-based surface treatments in the presence of osteoblasts and provides improved bone cell generation/repair and improved interface for secure attachment/bonding to bone. Methods for providing PEVCD-based silicon overlays onto surfaces are provided. Methods of increasing antioxidant enzyme (e.g., superoxide dismutase) expression at a treated surface for enhanced healing are also provided. Continuous generation and release of Si4+ ion into an in vitro or in vivo environment in the presence of osteoblasts/osteoblast progenitor cells, methods of employing same for enhancing the rate of bone healing/bone regeneration, is also described.
In an embodiment, the present disclosure pertains to a method of recycling that includes applying an electromagnetic field to a composite material having carbon fiber therein, heating the composition, degrading a matrix of the composite material, and recovering the carbon fiber from the composite material. In an additional embodiment, the present disclosure pertains to a method of non-contact recycling that includes applying an electromagnetic field to a composite material having carbon fiber therein with an electromagnetic applicator via at least one of direct current or alternating current, heating the composition, degrading a matrix of the composite material, and recovering the carbon fiber from the composite material. In some embodiments, the electromagnetic field is applied in a non-contact manner. In some embodiments, the heating is locally induced heating that includes increasing the temperature inside the composite material via an inside-out method thereby initiating pyrolysis within the composite material.
B29B 17/02 - Séparation de matières plastiques des autres matières
B29B 17/04 - Désintégration des matières plastiques
B29K 105/08 - Présentation, forme ou état de la matière moulée contenant des agents de renforcement, charges ou inserts de grande longueur, p. ex. ficelles, mèches, mats, tissus ou fils
The digital human workplace solution is deployed in a customer service setting and involves a computer programmed with a digital human that is displayed to interact with the customer and adapt to inputs providing information about the user or the environment. The digital human workforce solution is also programmed to interface with one or more databases of information that can be used during the customer service interaction.
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/0205 - Évaluation simultanée de l'état cardio-vasculaire et de l'état d'autres parties du corps, p. ex. de l'état cardiaque et respiratoire
83.
METHOD FOR CREATING CRUDE OIL SYNTHESIZED FLUID HAVING SURFACTANT AND DEMULSIFICATION PROPERTIES
A high voltage discharge generating a plasma wave front is disposed within a headspace over an oil-containing liquid in order to create various chemical changes within the headspace, and ultimately within the liquid in order to inactivate various microbes, synthesize new chemicals, speed separation of a mixture, and aid in oil extraction. Such a discharge may be repeated at an optimum duration and duty-cycle to maximize the chemical effects of the non-equilibrium plasma at a substantially lower temperature than for an equilibrium plasma.
C10G 33/02 - Déshydratation ou désémulsification des huiles d'hydrocarbures par des moyens électriques ou magnétiques
B01J 19/00 - Procédés chimiques, physiques ou physico-chimiques en généralAppareils appropriés
B01J 19/08 - Procédés utilisant l'application directe de l'énergie ondulatoire ou électrique, ou un rayonnement particulaireAppareils à cet usage
C09K 8/584 - Compositions pour les méthodes de récupération assistée pour l'extraction d'hydrocarbures, c.-à-d. pour améliorer la mobilité de l'huile, p. ex. fluides de déplacement caractérisées par l'utilisation de tensio-actifs spécifiques
C10G 33/04 - Déshydratation ou désémulsification des huiles d'hydrocarbures par des moyens chimiques
The digital human workplace solution is deployed in a customer service setting and involves a computer programmed with a digital human that is displayed to interact with the customer and adapt to inputs providing information about the user or the environment. The digital human workforce solution is also programmed to interface with one or more databases of information that can be used during the customer service interaction.
G16H 40/20 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion ou l’administration de ressources ou d’établissements de soins de santé, p. ex. pour la gestion du personnel hospitalier ou de salles d’opération
G06F 3/0487 - Techniques d’interaction fondées sur les interfaces utilisateur graphiques [GUI] utilisant des caractéristiques spécifiques fournies par le périphérique d’entrée, p. ex. des fonctions commandées par la rotation d’une souris à deux capteurs, ou par la nature du périphérique d’entrée, p. ex. des gestes en fonction de la pression exercée enregistrée par une tablette numérique
G06Q 30/01 - Services de relation avec la clientèle
G06V 40/16 - Visages humains, p. ex. parties du visage, croquis ou expressions
85.
DEFECT IDENTIFICATION FRAMEWORK FOR MANUFACTURING APPLICATIONS
A computer-implemented method for defect identification based on a defect category driven image analysis. The method includes receiving an image of a product having a manufacturing process applied to the product; categorizing the image based on an attribute of the product in the image; selecting, based on the categorizing, a subset of image processing methods; initiating application of the selected subset of image processing methods to the image; receiving output images, each from the application of one of the selected subset of image processing methods; determining scores, each for one of the subset of the image processing methods, wherein each of the scores is based on metrics associated with different image qualities of a respective one of the output images; selecting an image processing method from the subset of imaging processing methods based on the scores; and identifying a defect in the product based on the selected imaging processing method.
G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
The present disclosure provides a vascular graft comprising i) one or more extracellular matrix compositions and ii) one or more hydrogels. In particular, the vascular grafts of the present disclosure can be functionalized and/or be completely biologic. The disclosure also provides methods of administering the vascular grafts as well as methods for forming the vascular grafts.
A61L 27/36 - Matériaux pour prothèses ou pour revêtement de prothèses contenant des constituants de constitution indéterminée ou leurs produits réactionnels
A61L 27/54 - Matériaux biologiquement actifs, p. ex. substances thérapeutiques
A61L 33/00 - Traitement antithrombogénique d'articles chirurgicaux, p. ex. de sutures, cathéters, prothèses ou d'articles pour la manipulation ou le conditionnement du sangMatériaux pour un tel traitement
87.
METHODS AND COMPOSITIONS TARGETING NUCLEUS ACCUMBENS-ASSOCIATED PROTEIN-1 FOR TREATMENT OF AUTOIMMUNE DISORDERS AND CANCERS
Provided herein are methods of for enhancing or inducing an anti-tumor response or treating an autoimmune disorder by administering a therapeutically effective amount of an inhibitor of NAC 1. Also, provided herein are methods of enhancing effectiveness of a vaccine in a subject by administering to the subject a therapeutically effective amount of an inhibitor of NAC 1. Inhibitors of NAC1 can include a chemical agent, such as a composition containing NIC3, or a biological agent that inhibit the function of NAC1 protein, such as an isolated antibody or its binding fragment thereof that binds to NAC1. Inhibitors of NAC 1 can include a biological agent that reduces the expression of NAC1 gene, such as a NAC 1-targeted siRNA administered as a nanoliposome or a CRISPR/Cas-based genome editing composition targeting the NAC1 Gene.
The present invention provides a copolymer, preferably a degradable copolymer, comprising at least first and second repeat units and/or derived from at least first, second, and third monomers.
In an embodiment, a method for measuring parameters of a liquid, where the method includes measuring pressure drops across a flow meter, measuring pressure upstream of the flow meter, and identifying at least one liquid parameter based, at least in part, on a correlation of a change in a multiphase flow parameter to pulse output. In an additional embodiment, a measuring apparatus for measuring parameters of a liquid, where the measuring apparatus includes an electronic control operable to measure pressure drops across the measuring apparatus, measure pressure upstream of the measuring apparatus, and correlate a change in a multiphase parameter to measured pulse output of the measuring apparatus.
G01F 1/10 - Mesure du débit volumétrique ou du débit massique d'un fluide ou d'un matériau solide fluent, dans laquelle le fluide passe à travers un compteur par un écoulement continu en utilisant des effets mécaniques en utilisant des aubes tournantes avec admission axiale
G01F 1/34 - Mesure du débit volumétrique ou du débit massique d'un fluide ou d'un matériau solide fluent, dans laquelle le fluide passe à travers un compteur par un écoulement continu en utilisant des effets mécaniques en mesurant la pression ou la différence de pression
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
C12N 1/21 - BactériesLeurs milieux de culture modifiés par l'introduction de matériel génétique étranger
The present invention provides a polymer, preferably a degradable polymer, derived from monomers (A) and (B) and/or comprising a repeat unit of formula (ii) and at least one terminal group of formula (II).
Disclosed are methods and compositions for detecting glomerular disease in dogs and effectively treating dogs with glomerular diseases such as membranoproliferative immune complex-mediated glomerulonephritis (MPGN). Methods and compositions for detecting glomerular or tubular damage in cats and effectively treating cats with glomerular or tubular damage are also provided.
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
A61K 31/192 - Acides carboxyliques, p. ex. acide valproïque ayant des groupes aromatiques, p. ex. sulindac, acides 2-aryl-propioniques, acide éthacrynique
A61K 31/5377 - 1,4-Oxazines, p. ex. morpholine non condensées et contenant d'autres hétérocycles, p. ex. timolol
A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone substitués en position 21, p. ex. cortisone, dexaméthasone, prednisone ou aldostérone
An autonomous landing system includes a vertical landing aircraft, a visual cue coupled to an offshore landing platform and including a visual indicator located that extends vertically across a horizon and is maintained parallel with the horizon, and an autonomous control system configured to control a position of the aircraft with respect to the visual indicator to maneuver the aircraft into a hovering, predefined landing position above the offshore landing platform, and control the position of the aircraft with respect to the visual indicator to cause the aircraft to descend from the landing position and land on the offshore landing platform.
G08G 5/02 - Aides pour l'atterrissage automatique, c. à d. systèmes dans lesquels les données des vols d'avions arrivant sont traitées de façon à fournir les données d'atterrissage
The present invention provides a copolymer, preferably a degradable copolymer, comprising at least first and second repeat units and/or derived from at least first, second, and third monomers.
Tumor resection is commonly practiced to prevent the progression of cancer. However, there are post-surgery concerns including the formation of a void that can allow cancer cells to escape at the surgery site, which increases the risk of metastasis. To counter this challenge, an embodiment includes a polyurethane-based shape memory foam as a tissue void-filling device that can also release anti-cancer drugs. Such foams may activate at body temperature and become malleable. Such properties may enable the foam to be shaped to precisely seal the tissue void and then serve as a drug-eluting device. Based on the drug composition with poly vinyl alcohol (PVA), the drug release profile from the foam may be altered depending on the application.
A61L 27/18 - Matériaux macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone
A61L 27/54 - Matériaux biologiquement actifs, p. ex. substances thérapeutiques
A combination micro/macro-fluidic analysis system with one or more of a droplet transition unit, a droplet cleaving unit, a droplet synchronization, and a merging unit to enable highly efficient complex droplet microfluidic assays.
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
A61P 1/16 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des troubles de la vésicule biliaire ou du foie, p. ex. protecteurs hépatiques, cholagogues, cholélitholytiques
98.
SELF-SUFFICIENT LOW-COST MITIGATION MODEL TO IMPROVE RESILIENCE IN POWER UTILITY WILDFIRE RESPONSE
A method for predictive fire control, comprising identifying a plurality of wildfire risk points on a power grid, calculating a route for an unmanned aerial vehicle (UAV) to intersect with a maximum number of points as a function of a range of the UAV, controlling the UAV to traverse the route, monitoring one or more sensors for an indication of a wildfire event and controlling the UAV to release a fire retardant on the fire.
A62C 3/02 - Prévention, limitation ou extinction des incendies spécialement adaptées pour des objets ou des endroits particuliers pour des zones d'embrasement, p. ex. des incendies de forêts, des feux souterrains
B64D 1/16 - Largage en vol d'une matière poudreuse, liquide ou gazeuse, p. ex. pour la lutte contre l'incendie
G05D 1/656 - Interaction avec des charges utiles ou des entités externes
G05D 105/55 - Applications spécifiques des véhicules commandés pour les opérations d’urgence, p. ex. recherche et sauvetage, interventions en cas d’accidents de la circulation ou lutte contre les incendies
Augmented-reality (AR) instructions for assembly of a physical object may be based on an assembly sequence divided into multiple assembly phases, using separate computational three-dimensional (3D) registration models (e.g., object recognition models) for the different phases. A user may be guided step by step through the assembly sequence, using a step counter to keep track of where in the assembly sequence the user is. In each step, an AR image may be created by rendering, overlaid onto the camera image, a virtual model of a part of the physical object to be added during the step, spatially registered with the physical object in its partially assembled state.
G06F 3/04815 - Interaction s’effectuant dans un environnement basé sur des métaphores ou des objets avec un affichage tridimensionnel, p. ex. modification du point de vue de l’utilisateur par rapport à l’environnement ou l’objet
G06T 5/60 - Amélioration ou restauration d'image utilisant l’apprentissage automatique, p. ex. les réseaux neuronaux
G06T 17/20 - Description filaire, p. ex. polygonalisation ou tessellation
G06T 19/20 - Édition d'images tridimensionnelles [3D], p. ex. modification de formes ou de couleurs, alignement d'objets ou positionnements de parties
G06V 10/24 - Alignement, centrage, détection de l’orientation ou correction de l’image
G06V 20/20 - ScènesÉléments spécifiques à la scène dans les scènes de réalité augmentée
G06F 3/0484 - Techniques d’interaction fondées sur les interfaces utilisateur graphiques [GUI] pour la commande de fonctions ou d’opérations spécifiques, p. ex. sélection ou transformation d’un objet, d’une image ou d’un élément de texte affiché, détermination d’une valeur de paramètre ou sélection d’une plage de valeurs
G06T 7/33 - Détermination des paramètres de transformation pour l'alignement des images, c.-à-d. recalage des images utilisant des procédés basés sur les caractéristiques
G06V 10/75 - Organisation de procédés de l’appariement, p. ex. comparaisons simultanées ou séquentielles des caractéristiques d’images ou de vidéosApproches-approximative-fine, p. ex. approches multi-échellesAppariement de motifs d’image ou de vidéoMesures de proximité dans les espaces de caractéristiques utilisant l’analyse de contexteSélection des dictionnaires
G09B 5/02 - Matériel à but éducatif à commande électrique avec présentation visuelle du sujet à étudier, p. ex. en utilisant une bande filmée
H04N 23/63 - Commande des caméras ou des modules de caméras en utilisant des viseurs électroniques
In an embodiment, the present disclosure pertains to a supercapacitor composed of a cathode material, a gel electrolyte, and a zinc foil anode. In some embodiments, the cathode material, the gel electrolyte, and the zinc foil anode are in a multilayered configuration. In some embodiments, the cathode and anode materials provide load-bearing capability. In an additional embodiment, the present disclosure pertains to a method of making a supercapacitor. In general, the method includes fabricating a cathode material, preparing a gel electrolyte, coating a zinc foil electrode with the gel electrolyte, and sandwiching the zinc foil electrode with the cathode material. In some embodiments, the sandwiching forms a multilayered configuration composed of the cathode material, the gel electrolyte, and the zinc foil anode.
