The disclosure provides for electrode systems and perfusion systems that may be configured to measure the electrical activity of an explanted heart and to provide defibrillation energy as necessary. The perfusion systems may maintain the heart in a beating state at, or near, normal physiological conditions; circulate oxygenated, nutrient enriched perfusion fluid to the heart at or near physiological temperature, pressure, and/or flow rate. These systems may include a pair of electrodes that may be placed epicardially on the right atrium and/or left ventricle of the explanted heart, and/or an electrode placed in the aortic blood path.
A01N 1/168 - Physical preservation processes using electromagnetic fields or radiationPhysical preservation processes using acoustic waves or corpuscular radiation
The invention provides, in various embodiments, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to aortic cannulas for use in perfusion systems to return perfusate to the heart or delivering perfusate from the heart while the organ is sustained ex vivo at physiologic or near-physiologic conditions.
01 - Chemical and biological materials for industrial, scientific and agricultural use
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Chemical solutions for organ preservation, maintenance, evaluation or resuscitation Downloadable computer programs and downloadable mobile device software for wireless transmission of data, namely, data for organ transplant case initiation and management, transportation, logistics, organ procurement, organ management, organ preservation, invoicing, and billing; downloadable computer programs and downloadable mobile device software for wireless cloud storage of data; downloadable computer programs and downloadable mobile device software for connecting, operating, managing, and integrating devices to record, monitor, and analyze data Portable organ preservation systems comprising an organ chamber, perfusion circuit, temperature control means, oxygenation means, and flow control means; and organ chambers and perfusion circuits for use in portable organ preservation system Training and instructional services in connection with the use of portable organ preservation systems Providing temporary use of non-downloadable computer software for wireless transmission of data, namely, data for organ transplant case initiation and management, transportation, logistics, organ procurement, organ management, organ preservation, invoicing, and billing; providing temporary use of non-downloadable software for wireless cloud storage of data; providing temporary use of non-downloadable cloud-based software for connecting, operating, managing, and integrating devices to record, monitor, and analyze data Specialized medical services, namely, assessing and managing donor organs for transport and maintaining the condition of donor organs during transport
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
39 - Transport, packaging, storage and travel services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Downloadable computer programs and downloadable mobile device software for wireless transmission of data, namely, data for organ transplant case initiation and management, transportation, logistics, organ procurement, organ management, organ preservation, invoicing, and billing; downloadable computer programs and downloadable mobile device software for wireless cloud storage of data; downloadable computer programs and downloadable mobile device software for connecting, operating, managing, and integrating devices to record, monitor, and analyze data Portable organ preservation systems comprising an organ chamber, perfusion circuit, temperature control means, oxygenation means, and flow control means; and organ chambers and perfusion circuits for use in portable organ preservation system Transportation services, namely, transportation of medical personnel and pickup, transport, delivery and storage of organs and medical, surgical, and clinical equipment and supplies; logistics planning services, namely, for surgical organ retrieval and transportation of organs, medical, surgical, and clinical equipment and supplies, and medical personnel Providing temporary use of non-downloadable computer software for wireless transmission of data, namely, data for organ transplant case initiation and management, transportation, logistics, organ procurement, organ management, organ preservation, invoicing, and billing; providing temporary use of non-downloadable software for wireless cloud storage of data; providing temporary use of non-downloadable cloud-based software for connecting, operating, managing, and integrating devices to record, monitor, and analyze data Medical services; surgical organ retrieval, transplantation, preservation, perfusion, management, logistics, and transportation; organ management using portable organ preservation systems; providing a website featuring information in the fields of organ transplantation, preservation, perfusion, transportation, and organ management using portable organ preservation systems; specialized medical services, namely, assessing and managing donor organs for transport and maintaining the condition of donor organs during transport
09 - Scientific and electric apparatus and instruments
39 - Transport, packaging, storage and travel services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Downloadable computer programs and downloadable mobile device software for use in transportation services, namely, transportation of medical personnel, and pickup, transport, delivery and storage of organs, medical equipment and supplies; downloadable computer programs and downloadable mobile device software for logistics planning services, namely, for surgical organ retrieval and transportation of organs, medical, surgical, and clinical equipment and supplies, and medical personnel; downloadable computer programs and downloadable mobile device software for medical services, organ transplantation, preservation, perfusion, and organ management using portable organ preservation systems; downloadable computer programs and downloadable mobile device software for wireless transmission of data, namely, data for organ transplant case initiation and management, transportation, logistics, organ procurement, organ management, organ preservation, invoicing, and billing; downloadable computer programs and downloadable mobile device software for wireless cloud storage of data; downloadable computer programs and downloadable mobile device software for connecting, operating, managing, and integrating devices to record, monitor, and analyze data, namely, data for organ transplant case initiation and management, transportation, logistics, organ procurement, organ management, organ preservation, invoicing, and billing Transportation services, namely, transportation of medical personnel and pickup, transport, delivery and storage of organs and medical, surgical, and clinical equipment and supplies; logistics planning services, namely, for surgical organ retrieval and transportation of organs, medical, surgical, and clinical equipment and supplies, and medical personnel Providing temporary use of non-downloadable computer software for use in transportation services, namely, transportation of medical personnel, and pickup, transport, delivery and storage of organs, medical, surgical, and clinical equipment and supplies; providing temporary use of non-downloadable computer software for logistics planning services, namely, for surgical organ retrieval and transportation of organs, medical, surgical, and clinical equipment and supplies, and medical personnel; providing temporary use of non-downloadable computer software for medical services, organ transplantation, preservation, perfusion, and organ management using portable organ preservation systems; providing temporary use of non-downloadable computer software for wireless transmission of data, namely, data for organ transplant case initiation and management, transportation, logistics, organ procurement, organ management, organ preservation, invoicing, and billing; providing temporary use of non-downloadable software for wireless cloud storage of data; providing temporary use of non-downloadable cloud-based software for connecting, operating, managing, and integrating devices to record, monitor, and analyze data, namely, data for organ transplant case initiation and management, transportation, logistics, organ procurement, organ management, organ preservation, invoicing, and billing Medical services; surgical organ retrieval, transplantation, preservation, perfusion, management, logistics, and transportation; organ management using portable organ preservation systems; providing a website featuring information in the fields of organ transplantation, preservation, perfusion, transportation, and organ management using portable organ preservation systems; specialized medical services, namely, assessing and managing donor organs for transport and maintaining the condition of donor organs during transport
The disclosure provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the disclosure relates to maintaining an organ ex-vivo at near physiologic conditions. In certain embodiments, the disclosure relates to placing an ex-vivo heart in a chamber of a portable organ care system; providing, via a pump, a pulsatile flow of a perfusion fluid to the ex-vivo heart; measuring, with a sensor, one or more physiologic characteristics of the ex-vivo heart while the ex-vivo heart is beating; and operating the pump in response to the one or more physiologic characteristics.
In a method of ventilating excised lungs, a ventilation gas is supplied to an airway of a lung and a vacuum is formed around the lung. A quality of the vacuum is varied between a lower level and a higher level to cause the lung to breathe, while the pressure of the ventilation gas supplied to the airway is regulated to maintain a positive airway pressure in the airway of the lung. The vacuum may be cyclically varied between the two vacuum levels. The levels may be maintained substantially constant over a period of time, or one or both of the lower and higher levels may be adjusted during ventilation. The lung may be placed in a sealed chamber, and a vacuum is formed in the chamber around the lung.
The disclosure provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the disclosure relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes, for example, a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate, for example, the: 1) overall perfusion status of an isolated heart; 2) metabolic status of an isolated heart; and 3) overall vascular patency of an isolated donor heart. This aspect of the present disclosure may use, for example, the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.
Apparatus for perfusion of multiple types of organs include base unit configured to removably couple with a perfusion module for perfusing an organ. The base unit has conduits for connecting a source of a perfusate to the organ to circulate the perfusate through the organ; first and second pumps coupled to the conduits for driving circulation of the perfusate in the conduits; and a controller configured and connected for controlling the first and second pumps to regulate the circulation of the perfusate through the organ. The controller is operable to control the first and second pumps to perfuse the organ in accordance with organ specific perfusion parameters. The organ specific perfusions parameters are selected based on the type of the organ, and may be selected by an operator for at least two organ types selected from the group of heart, liver, kidney and lung.
The disclosure generally relates to a system for perfusing an ex-vivo liver including a pump configured to pump a perfusion fluid through a perfusion circuit, the pump in fluid communication with a hepatic artery interface and a portal vein interface; an oxygenator; a heater; an inferior vena cava interface in fluid communication with an inferior vena cava of the ex-vivo liver; and a reservoir configured to receive the perfusion fluid from the inferior vena cava of the ex-vivo liver and store a volume of fluid.
The disclosure provides for electrode systems and perfusion systems that may be configured to measure the electrical activity of an explanted heart and to provide defibrillation energy as necessary. The perfusion systems may maintain the heart in a beating state at, or near, normal physiological conditions; circulate oxygenated, nutrient enriched perfusion fluid to the heart at or near physiological temperature, pressure, and/or flow rate. These systems may include a pair of electrodes that may be placed epicardially on the right atrium and/or left ventricle of the explanted heart, and/or an electrode placed in the aortic blood path.
A valve assembly includes a conduit comprising a first end and a second end and two control valves. Each valve comprises three ports and a spool for selectively adjusting a proportion of fluid flows through two of the ports. First ports of the valves are for connection with intake or output port of a pump respectively. Second ports of the valves are connected to the second end of the conduit for withdrawing fluid from the conduit or supplying fluid to the conduit respectively. The valve may be included in a ventilator to control the application of variable pressure to exterior surface of a lung in a sealed chamber to cause the lung to breathe.
A61M 16/20 - Valves specially adapted to medical respiratory devices
F16K 11/07 - Multiple-way valves, e.g. mixing valvesPipe fittings incorporating such valvesArrangement of valves and flow lines specially adapted for mixing fluid with all movable sealing faces moving as one unit comprising only sliding valves with linearly sliding closure members with cylindrical slides
An ex-vivo lung solution for machine perfusion of donor lungs on OCS. The solution may be mixed with whole blood or packed red blood cells to form the OCS lung perfusion solution.
The disclosure, in various embodiments, provides systems, methods, and solutions for perfusing an organ. The present application describes illustrative methods for perfusing an ex-vivo organ in a functioning state under physiological or near physiological conditions, including receiving an ex-vivo organ in an organ care system, the ex-vivo organ coupled to a perfusion circuit, infusing a solution into the system, combining the solution with a perfusion fluid to create a mixed solution, pumping the mixed solution to the ex-vivo organ, and receiving the mixed solution from the ex-vivo organ.
In a method of ventilating excised lungs, a ventilation gas is supplied to an airway of a lung and a vacuum is formed around the lung. A quality of the vacuum is varied between a lower level and a higher level to cause the lung to breathe, while the pressure of the ventilation gas supplied to the airway is regulated to maintain a positive airway pressure in the airway of the lung. The vacuum may be cyclically varied between the two vacuum levels. The levels may be maintained substantially constant over a period of time, or one or both of the lower and higher levels may be adjusted during ventilation. The lung may be placed in a sealed chamber, and a vacuum is formed in the chamber around the lung.
The invention provides, in various embodiments, a method comprising placing an ex-vivo heart in a chamber of an organ care system; connecting the ex-vivo heart to a perfusion fluid circuit of the organ care system; starting a pump configured to provide, via the perfusion fluid circuit, a perfusion fluid to the ex-vivo heart; synchronizing at least one maximum output of the pump with an r-wave of the ex-vivo heart; testing the ex-vivo heart or the organ care system; adjusting a setting of the organ care system in response to a result of the testing; and after adjusting the setting of the organ care system in response to the result of the testing, re-testing the ex-vivo heart or the organ care system.
The disclosure provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the disclosure relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes, for example, a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate, for example, the: 1) overall perfusion status of an isolated heart; 2) metabolic status of an isolated heart; and 3) overall vascular patency of an isolated donor heart. This aspect of the present disclosure may use, for example, the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Computer programs, downloadable computer programs and
downloadable mobile device software for use in case
management for assigning surgical and clinical resources to
transplant cases, for tracking and reporting on numbers of
transplant cases, for monitoring and tracking status of
organs on journey from donors to recipients, and for
communicating with team members on case logistics. Providing non-downloadable computer software for use in case
management for assigning surgical and clinical resources to
transplant cases, for tracking and reporting on numbers of
transplant cases, for monitoring and tracking status of
organs on journey from donors to recipients, and for
communicating with team members on case logistics.
20.
Apparatus and method for ex vivo lung ventilation with a varying exterior pressure
In a method of ventilating excised lungs, a ventilation gas is supplied to an airway of a lung and a vacuum is formed around the lung. A quality of the vacuum is varied between a lower level and a higher level to cause the lung to breathe, while the pressure of the ventilation gas supplied to the airway is regulated to maintain a positive airway pressure in the airway of the lung. The vacuum may be cyclically varied between the two vacuum levels. The levels may be maintained substantially constant over a period of time, or one or both of the lower and higher levels may be adjusted during ventilation. The lung may be placed in a sealed chamber, and a vacuum is formed in the chamber around the lung.
An ex-vivo lung solution for machine perfusion of donor lungs on OCS. The solution may be mixed with whole blood or packed red blood cells to form the OCS lung perfusion solution.
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Recorded computer programs, downloadable computer programs and downloadable mobile device software for use in case management for assigning surgical and clinical resources to transplant cases, for tracking and reporting on numbers of transplant cases, for monitoring and tracking status of organs on journey from donors to recipients, and for communicating with team members on case logistics Providing temporary use of non-downloadable computer software for use in case management for assigning surgical and clinical resources to transplant cases, for tracking and reporting on numbers of transplant cases, for monitoring and tracking status of organs on journey from donors to recipients, and for communicating with team members on case logistics
The disclosure generally relates to a system for perfusing an ex-vivo liver including a pump configured to pump a perfusion fluid through a perfusion circuit, the pump in fluid communication with a hepatic artery interface and a portal vein interface; an oxygenator; a heater; an inferior vena cava interface in fluid communication with an inferior vena cava of the ex-vivo liver; and a reservoir configured to receive the perfusion fluid from the inferior vena cava of the ex-vivo liver and store a volume of fluid.
The disclosure provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the disclosure relates to maintaining an organ ex-vivo at near physiologic conditions. In certain embodiments, the disclosure relates to testing properties of an ex-vivo heart or an organ care system, adjusting a property of the organ care system in response to certain results of the testing, and re-testing the ex-vivo heart or the organ care system. In certain embodiments, the disclosure relates to synchronizing at least one cycle of a pumping of a perfusion fluid with a state of the ex-vivo heart.
The invention generally relates to systems, methods, and devices for ex vivo organ care. More particularly, in various embodiments, the invention relates to caring for a liver ex vivo at physiologic or near-physiologic conditions.
An apparatus, a system, and methods for receiving, perfusing and maintaining and assessing excised donor heart physiological functionality. The system generally comprises an apparatus for receiving and holding an excised heart that is interconnected with: (i) a perfusate-processing system, (ii) a bi-directional perfusate pumping system, (iii) flow sensors for monitoring the flow of perfusate to and from an installed heart's aorta, pulmonary artery, pulmonary vein, and vena cava, (iv) an ECG apparatus interconnectable with the installed heart, and (v) probes interconnecting the installed heart with instruments for monitoring the heart's physiological functionality using load independent indices and load dependent indices.
Apparatus for perfusion of multiple types of organs include base unit configured to removably couple with a perfusion module for perfusing an organ. The base unit has conduits for connecting a source of a perfusate to the organ to circulate the perfusate through the organ; first and second pumps coupled to the conduits for driving circulation of the perfusate in the conduits; and a controller configured and connected for controlling the first and second pumps to regulate the circulation of the perfusate through the organ. The controller is operable to control the first and second pumps to perfuse the organ in accordance with organ specific perfusion parameters. The organ specific perfusions parameters are selected based on the type of the organ, and may be selected by an operator for at least two organ types selected from the group of heart, liver, kidney and lung.
The invention provides, in various embodiments, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to aortic cannulas for use in perfusion systems to return perfusate to the heart or delivering perfusate from the heart while the organ is sustained ex vivo at physiologic or near-physiologic conditions.
In a method of ventilating excised lungs, a ventilation gas is supplied to an airway of a lung and a vacuum is formed around the lung. A quality of the vacuum is varied between a lower level and a higher level to cause the lung to breathe, while the pressure of the ventilation gas supplied to the airway is regulated to maintain a positive airway pressure in the airway of the lung. The vacuum may be cyclically varied between the two vacuum levels. The levels may be maintained substantially constant over a period of time, or one or both of the lower and higher levels may be adjusted during ventilation. The lung may be placed in a sealed chamber, and a vacuum is formed in the chamber around the lung.
Disclosed is a device for supporting and connecting an excised organ (such as a heart, a pair of lungs, a kidney, or a liver) during ex vivo perfusion. The device includes a resilient and flexible sheet having a first portion for contacting and supporting the organ thereon, and a second portion comprising an opening for forming a connection between the organ and a conduit to allow fluid communication between the conduit and the organ. The device also includes a magnetic material embedded in the second portion of the sheet for magnetically securing the connection between the conduit and the organ.
Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.
2+) in the solution is from 0.18 to 0.26 mmol/L, and the pH is lower than 7.4 and higher than 6.6. A composition for preparing the solution may comprise adenosine, lidocaine, and a calcium source, wherein the molar ratio of adenosine:calcium is from 0.3:0.26 to 0.45:0.18, and the molar ratio of lidocaine:calcium is from 0.04:0.26 to 0.09:0.18. A donor heart may be reperfused with the solution. The solution may be used for reperfusion of a donor heart, such as at a temperature from about 25 to about 37° C. The donor may be a donor after circulatory death.
A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
34.
Apparatus for testing, assessment, and maintenance of harvested hearts for transplanting
An apparatus, a system, and methods for receiving, perfusing and maintaining and assessing excised donor heart physiological functionality. The system generally comprises an apparatus for receiving and holding an excised heart that is interconnected with: (i) a perfusate-processing system, (ii) a bi-directional perfusate pumping system, (iii) flow sensors for monitoring the flow of perfusate to and from an installed heart's aorta, pulmonary artery, pulmonary vein, and vena cava, (iv) an ECG apparatus interconnectable with the installed heart, and (v) probes interconnecting the installed heart with instruments for monitoring the heart's physiogical functionality using load independent indices and load dependent indices.
Medical apparatus and instruments for organ perfusion and reperfusion; medical devices for preserving human organs awaiting transplantation; portable medical devices for preserving human organs awaiting transplantation; medical devices for assessing viability of human organs awaiting transplantation; portable medical devices for assessing viability of human organs awaiting transplantation; medical devices for resuscitating human organs for organ transplantation; portable medical devices for resuscitating human organs for organ transplantation; medical apparatus and instruments for use in organ transplant; medical apparatus and instruments for resuscitation, preservation, and assessment of explanted organs; medical apparatus and instruments for resuscitation, preservation, and assessment of explanted organs, namely, hearts, lungs, livers and kidneys; heart monitors; medical ventilators; medical respirators; respirators; respirators for artificial respiration; resuscitators; magnetic connectors for medical purposes; pumps for medical purposes; pumps for medical purposes, namely, pumps for controllably circulating fluids and solutions through explanted organs, and pumps for use in perfusion circuits; perfusion pumps; valves for pumps used in the field of organ perfusion, reperfusion, preservation and transplantation; surgical and medical apparatus and instruments for assessment and transplant of organs; surgical and medical apparatus and instruments for perfusion and reperfusion of organs with fluid for the purpose of preservation, maintenance, assessment and resuscitation; portable organ preservation and transportation systems comprising an organ chamber, perfusion circuit, temperature control means, oxygenation means, and flow control means; organ chambers and perfusion circuits for use in portable organ preservation systems.
36.
Systems for monitoring and applying electrical currents in an organ perfusion system
Electrode systems have been developed for use in perfusion systems to measure the electrical activity of an explanted heart and to provide defibrillation energy as necessary. The perfusion systems maintain the heart in a beating state at, or near, normal physiological conditions; circulating oxygenated, nutrient enriched perfusion fluid to the heart at or near physiological temperature, pressure and flow rate. These systems include a pair of electrodes that are placed epicardially on the right atrium and left ventricle of the explanted heart, as well as an electrode placed in the aortic blood path.
The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.
An organ care system including a blood product heater that includes a heater inlet, a channel, and a heater outlet, wherein the heater inlet includes an inside cross-sectional area and an inside cross-sectional shape configured to flow a blood product into the blood product heater, wherein the heater outlet comprises an inside cross-sectional area and an inside cross-sectional shape configured to flow the blood product out of the blood product heater, and wherein the channel extends between the heater inlet and the heater outlet and is formed between a first flow channel plate and a second flow channel plate; and a first heater thermally coupled to the first flow channel plate configured to heat the first flow channel plate; and a pump configured to circulate a heated blood product to an organ being preserved.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
37 - Construction and mining; installation and repair services
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
Goods & Services
(1) Medical preparations and solutions for use in organ transplantation; medical preparations and solutions for preserving human organs awaiting transplantation; cardioplegic solutions; cardioplegic solutions used in cardiac surgery; blood substitutes; blood plasma substitutes; blood substitutes and blood plasma substitutes for medical purposes, namely, for use in the resuscitation, preservation, and assessment of explanted organs;
(2) Medical devices for preserving human organs awaiting transplantation; portable medical devices for preserving human organs awaiting transplantation; medical devices for assessing viability of human organs awaiting transplantation; portable medical devices for assessing viability of human organs awaiting transplantation; medical devices for resuscitating human organs for organ transplantation; portable medical devices for resuscitating human organs for organ transplantation; heart monitors; medical ventilators; medical respirators; respirators for artificial respiration; resuscitators; pumps for medical purposes, namely, pumps for controllably circulating fluids and solutions through explanted organs, and pumps for use in perfusion circuits; perfusion pumps; (1) Installation, maintenance and repair of medical and surgical devices, apparatus and instruments; Installation, maintenance and repair of medical and surgical devices, apparatus and instruments in the field of preservation, maintenance, assessment and resuscitation of organs
(2) Conducting medical training in the use of medical and surgical devices; providing training in the use of surgical and medical apparatus and instruments in the field of preservation, maintenance, assessment and resuscitation of organs
(3) Medical research; medical research laboratory services; research and development in the field of organ donation and transplantation; design and development of medical and surgical products, apparatus, equipment, instruments and preparations, and advisory services thereto; scientific research for medical purposes in the field of preservation, maintenance, assessment and resuscitation of organs;
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
37 - Construction and mining; installation and repair services
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
Goods & Services
(1) Medical preparations and solutions for use in organ transplantation; medical preparations and solutions for preserving human organs awaiting transplantation; cardioplegic solutions; cardioplegic solutions used in cardiac surgery; blood substitutes; blood plasma substitutes; blood substitutes and blood plasma substitutes for medical purposes, namely, for use in the resuscitation, preservation, and assessment of explanted organs;
(2) Medical devices for preserving human organs awaiting transplantation; portable medical devices for preserving human organs awaiting transplantation; medical devices for assessing viability of human organs awaiting transplantation; portable medical devices for assessing viability of human organs awaiting transplantation; medical devices for resuscitating human organs for organ transplantation; portable medical devices for resuscitating human organs for organ transplantation; heart monitors; medical ventilators; medical respirators; respirators for artificial respiration; resuscitators; pumps for medical purposes, namely, pumps for controllably circulating fluids and solutions through explanted organs, and pumps for use in perfusion circuits; perfusion pumps; (1) Installation, maintenance and repair of medical and surgical devices, apparatus and instruments; Installation, maintenance and repair of medical and surgical devices, apparatus and instruments in the field of preservation, maintenance, assessment and resuscitation of organs
(2) Conducting medical training in the use of medical and surgical devices; providing training in the use of surgical and medical apparatus and instruments in the field of preservation, maintenance, assessment and resuscitation of organs
(3) Medical research; medical research laboratory services; research and development in the field of organ donation and transplantation; design and development of medical and surgical products, apparatus, equipment, instruments and preparations, and advisory services thereto; scientific research for medical purposes in the field of preservation, maintenance, assessment and resuscitation of organs;
The invention provides, in various embodiments, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to aortic cannulas for use in perfusion systems to return perfusate to the heart or delivering perfusate from the heart while the organ is sustained ex vivo at physiologic or near-physiologic conditions.
The invention generally relates to systems, methods, and devices for ex vivo organ care. More particularly, in various embodiments, the invention relates to caring for a liver ex vivo at physiologic or near-physiologic conditions.
2+) in the solution is from 0.18 to 0.26 mmol/L, and the pH is lower than 7.4 and higher than 6.6. A composition for preparing the solution may comprise adenosine, lidocaine, and a calcium source, wherein the molar ratio of adenosine:calcium is from 0.3:0.26 to 0.45:0.18, and the molar ratio of lidocaine:calcium is from 0.04:0.26 to 0.09:0.18. A donor heart may be reperfused with the solution. The solution may be used for reperfusion of a donor heart, such as at a temperature from about 25 to about 37° C. The donor may be a donor after circulatory death.
A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.
Apparatus for perfusion of multiple types of organs include base unit configured to removably couple with a perfusion module for perfusing an organ. The base unit has conduits for connecting a source of a perfusate to the organ to circulate the perfusate through the organ; first and second pumps coupled to the conduits for driving circulation of the perfusate in the conduits; and a controller configured and connected for controlling the first and second pumps to regulate the circulation of the perfusate through the organ. The controller is operable to control the first and second pumps to perfuse the organ in accordance with organ specific perfusion parameters. The organ specific perfusions parameters are selected based on the type of the organ, and may be selected by an operator for at least two organ types selected from the group of heart, liver, kidney and lung.
An apparatus, a system, and methods for receiving, perfusing and maintaining and assessing excised donor heart physiological functionality. The system generally comprises an apparatus for receiving and holding an excised heart that is interconnected with: (i) a perfusate-processing system, (ii) a bi-directional perfusate pumping system, (iii) flow sensors for monitoring the flow of perfusate to and from an installed heart's aorta, pulmonary artery, pulmonary vein, and vena cava, (iv) an ECG apparatus interconnectable with the installed heart, and (v) probes interconnecting the installed heart with instruments for monitoring the heart's physiogical functionality using load independent indices and load dependent indices.
An apparatus, a system, and methods for maintaining and monitoring an excized donor heart. The apparatus comprises a first component for receiving and submerging therein an excized heart in a constantly circulating perfusate solution and a second component comprising equipment for adjusting the temperature and oxygen content of the perfusate solution. The first component comprises an integral pair of defibrillating pads. A first conduit infrastructure interconnects the first module, the second module and an aorta of the excized donor heart pushing a perfusion solution from the first module through the second module into the aorta. The second conduit infrastructure connects the first module with the right atrium and the left atrium for pushing the perfusion solution from the first module into the atria. The third conduit infrastructure connects the first module with the pulmonary artery and provides an after pressure to the flow of the perfusion solution from the pulmonary artery.
An aortic cannula for use in an ex-vivo organ care system. The aortic cannula includes a cannula body. The cannula body includes a fitting adapted to connect to an ex-vivo organ care system; and an aorta interface configured to contact an aorta. The aortic cannula includes a pivot arm comprising a pivot arm strap, and the pivot arm strap is operably connected to a pivot mount, and the pivot mount is configured to allow the pivot arm strap to contact the aorta to hold the aorta on the aorta interface. The aortic cannula includes a spring configured to apply a pressure to the pivot arm strap to hold the aorta on the aorta interface.
The invention provides, in various embodiments, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to aortic cannulas for use in perfusion systems to return perfusate to the heart or delivering perfusate from the heart while the organ is sustained ex vivo at physiologic or near-physiologic conditions.
The invention provides, in various embodiments, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to aortic cannulas for use in perfusion systems to return perfusate to the heart or delivering perfusate from the heart while the organ is sustained ex vivo at physiologic or near-physiologic conditions.
−4 mmol/L; and a pH of 6.9. The oxygenated cardioplegic composition is pre-warmed to about 35° C. and then used for immediate reperfusion of a donor heart for at least three minutes after its procurement.
Electrode systems have been developed for use in perfusion systems to measure the electrical activity of an explanted heart and to provide defibrillation energy as necessary. The perfusion systems maintain the heart in a heating state at, or near, normal physiological conditions; circulating oxygenated, nutrient enriched perfusion fluid to the heart at or near physiological temperature, pressure and flow rate. These systems include a pair of electrodes that are placed epicardially on the right atrium and left ventricle of the explanted heart, as well as an electrode placed in the aortic blood path.
The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.
The invention generally relates to systems, methods, and devices for ex vivo organ care. More particularly, in various embodiments, the invention relates to caring for a liver ex vivo at physiologic or near-physiologic conditions. Other embodiments of the disclosed subject matter are possible. Embodiments of the disclosed subject matter can provide techniques relating to portable ex vivo organ care, such as ex vivo liver organ care. In some embodiments, the liver care system can maintain the liver at, or near, normal physiological conditions. To this end, the system can circulate an oxygenated, nutrient enriched perfusion fluid to the liver at or near physiological temperature, pressure, and flow rate.
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
The invention generally relates to systems, methods, and devices for ex vivo organ care. More particularly, in various embodiment, the invention relates to caring for a liver ex vivo at physiologic or near-physiologic conditions. The below summary is exemplary only, and not limiting. Other embodiment of the disclosed subject matter are possible. Embodiment of the disclosed subject matter can provide techniques relating to portable ex vivo organ care, such as ex vivo liver organ care. In some embodiment, the liver care system can maintain the liver at, or near, normal physiological conditions. To this end, the system can circulate an oxygenated, nutrient enriched perfusion fluid to the liver at or near physiological temperature, pressure, and flow rate.
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
The invention generally relates to systems, methods, and devices for ex vivo organ care. More particularly, in various embodiment, the invention relates to caring for a liver ex vivo at physiologic or near-physiologic conditions. The below summary is exemplary only, and not limiting. Other embodiment of the disclosed subject matter are possible. Embodiment of the disclosed subject matter can provide techniques relating to portable ex vivo organ care, such as ex vivo liver organ care. In some embodiment, the liver care system can maintain the liver at, or near, normal physiological conditions. To this end, the system can circulate an oxygenated, nutrient enriched perfusion fluid to the liver at or near physiological temperature, pressure, and flow rate.
The invention generally relates to systems, methods, and devices for ex vivo organ care. More particularly, in various embodiments, the invention relates to caring for a liver ex vivo at physiologic or near-physiologic conditions.
directional perfusate pumping system, (in) flow sensors for monitoring the flow of perfusate to and from an installed heart's aorta, pulmonary artery, pulmonary vein, and vena cava, (iv) an ECG apparatus interconnectable with the installed heart, and (v) probes interconnecting the installed heart with instruments for monitoring the heart's physiogical functionality using load independent indices and load dependent indices.
Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.
An ex-vivo lung solution for machine perfusion of donor lungs on OCS. The solution may be mixed with whole blood or packed red blood cells to form the OCS lung perfusion solution.
64.
ORGAN CARE SOLUTION FOR EX-VIVO MACHINE PERFUSION OF DONOR LUNGS
An ex-vivo lung solution for machine perfusion of donor lungs on OCS. The solution may be mixed with whole blood or packed red blood cells to form the OCS lung perfusion solution.
65.
ORGAN CARE SOLUTION FOR EX-VIVO MACHINE PERFUSION OF DONOR LUNGS
An ex-vivo lung solution for machine perfusion of donor lungs on OCS. The solution may be mixed with whole blood or packed red blood cells to form the OCS lung perfusion solution.
An ex-vivo lung solution for machine perfusion of donor lungs on OCS. The solution may be mixed with whole blood or packed red blood cells to form the OCS lung perfusion solution.
A61B 19/00 - Instruments, implements or accessories for surgery or diagnosis not covered by any of the groups A61B 1/00-A61B 18/00, e.g. for stereotaxis, sterile operation, luxation treatment, wound edge protectors(protective face masks A41D 13/11; surgeons' or patients' gowns or dresses A41D 13/12; devices for carrying-off, for treatment of, or for carrying-over, body liquids A61M 1/00)
A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes
01 - Chemical and biological materials for industrial, scientific and agricultural use
10 - Medical apparatus and instruments
41 - Education, entertainment, sporting and cultural services
Goods & Services
(1) Chemical solutions for organ preservation, maintenance, evaluation and resuscitation.
(2) Portable organ preservation systems comprising an organ chamber, perfusion circuit, temperature control means, oxygenation means, and flow control means; and Organ chambers and Perfusion circuits for use in portable organ preservation systems. (1) Training and instructional services in connection with the use of portable organ preservation systems.
G01N 33/567 - ImmunoassayBiospecific binding assayMaterials therefor using specific carrier or receptor proteins as ligand binding reagent utilising isolate of tissue or organ as binding agent
A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes
A61M 16/10 - Preparation of respiratory gases or vapours
A61M 11/00 - Sprayers or atomisers specially adapted for therapeutic purposes
Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and theventilation gas. Evaluating the gas exchange capability of the lung involvesdeoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilatingthe lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex- vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.
The invention provides, in various embodiments, systems, devices and methods relating to ex-vivoorgan care. In certain embodiments, the invention relates to maintaining an organ ex- vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.
82.
SYSTEMS AND METHODS FOR EX-VIVO ORGAN CARE AND FOR USING LACTATE AS AN INDICATION OF DONOR ORGAN STATUS
The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex- vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.
Electrode systems have been developed for use in perfusion systems to measure the electrical activity of an explanted heart and to provide defibrillation energy as necessary. The perfusion systems maintain the heart in a beating state at, or near, normal physiological conditions; circulating oxygenated, nutrient enriched perfusion fluid to the heart at or near physiological temperature, pressure and flow rate. These systems include a pair of electrodes that are placed epicardially on the right atrium and left ventricle of the explanted heart, as well as an electrode placed in the aortic blood path.
C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.
The invention provides systems, methods and solutions for perfusing a lung ex vivo. A method for perfusing a lung ex vivo comprises connecting the lung within a fluid perfusion circuit, flowing a perfusion fluid into the lung through a pulmonary artery interface and away from the lung through a pulmonary vein interface, providing a respiratory gas to the lung for use in metabolism by the lung, the respiratory gas having a pre-determined composition of oxygen, and ventilating the lung through a tracheal interface.
The invention provides systems, methods and solutions for perfusing a lung ex vivo. A method for perfusing a lung ex vivo comprises connecting the lung within a fluid perfusion circuit, flowing a perfusion fluid into the lung through a pulmonary artery interface and away from the lung through a pulmonary vein interface, providing a respiratory gas to the lung for use in metabolism by the lung, the respiratory gas having a pre-determined composition of oxygen, and ventilating the lung through a tracheal interface.
01 - Chemical and biological materials for industrial, scientific and agricultural use
10 - Medical apparatus and instruments
41 - Education, entertainment, sporting and cultural services
Goods & Services
Chemical solutions for organ preservation, maintenance,
evaluation or resuscitation. Portable organ preservation systems comprising an organ
chamber, perfusion circuit, temperature control means,
oxygenation means, and flow control means; organ chambers
and perfusion circuits for use in portable organ
preservation systems. Training and instructional services in connection with the
use of portable organ preservation systems.
91.
Method of timing pulsatile flow of normothermic perfusate to the heart
The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.
01 - Chemical and biological materials for industrial, scientific and agricultural use
10 - Medical apparatus and instruments
41 - Education, entertainment, sporting and cultural services
Goods & Services
(1) Chemical solutions for organ preservation, maintenance, evaluation or resuscitation.
(2) Portable organ preservation systems comprising an organ chamber, perfusion circuit, temperature control means, oxygenation means, and flow control means; and organ chambers and perfusion circuits for use in portable organ preservation systems. (1) Training and instructional services in connection with the use of portable organ preservation systems.
Portable organ preservation systems comprising an organ chamber, perfusion circuit, temperature control means, oxygenation means, and flow control means; and organ chambers and perfusion circuits for use in portable organ preservation systems
The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.
F04B 7/00 - Piston machines or pumps characterised by having positively-driven valving
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.
The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.
The invention provides, in various embodiments, systems and devices relating to a blood product heater for use in an ex-vivo organ care. In certain embodiments, the invention relates to maintaining a perfusion fluid flowing through the heater at near-physiologic conditions.
