In a method of ventilating excised lungs, a ventilation gas is supplied to an airway of a lung and a vacuum is formed around the lung. A quality of the vacuum is varied between a lower level and a higher level to cause the lung to breathe, while the pressure of the ventilation gas supplied to the airway is regulated to maintain a positive airway pressure in the airway of the lung. The vacuum may be cyclically varied between the two vacuum levels. The levels may be maintained substantially constant over a period of time, or one or both of the lower and higher levels may be adjusted during ventilation. The lung may be placed in a sealed chamber, and a vacuum is formed in the chamber around the lung.
The disclosure provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the disclosure relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes, for example, a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate, for example, the: 1) overall perfusion status of an isolated heart; 2) metabolic status of an isolated heart; and 3) overall vascular patency of an isolated donor heart. This aspect of the present disclosure may use, for example, the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.
Apparatus for perfusion of multiple types of organs include base unit configured to removably couple with a perfusion module for perfusing an organ. The base unit has conduits for connecting a source of a perfusate to the organ to circulate the perfusate through the organ; first and second pumps coupled to the conduits for driving circulation of the perfusate in the conduits; and a controller configured and connected for controlling the first and second pumps to regulate the circulation of the perfusate through the organ. The controller is operable to control the first and second pumps to perfuse the organ in accordance with organ specific perfusion parameters. The organ specific perfusions parameters are selected based on the type of the organ, and may be selected by an operator for at least two organ types selected from the group of heart, liver, kidney and lung.
The disclosure generally relates to a system for perfusing an ex-vivo liver including a pump configured to pump a perfusion fluid through a perfusion circuit, the pump in fluid communication with a hepatic artery interface and a portal vein interface; an oxygenator; a heater; an inferior vena cava interface in fluid communication with an inferior vena cava of the ex-vivo liver; and a reservoir configured to receive the perfusion fluid from the inferior vena cava of the ex-vivo liver and store a volume of fluid.
A61M 11/00 - Pulvérisateurs ou vaporisateurs spécialement destinés à des usages médicaux
A61M 11/04 - Pulvérisateurs ou vaporisateurs spécialement destinés à des usages médicaux agissant par pression de la vapeur des liquides à pulvériser ou vaporiser
A61M 16/00 - Dispositifs pour agir sur le système respiratoire des patients par un traitement au gaz, p.ex. bouche-à-bouche; Tubes trachéaux
A61M 16/10 - Préparation de gaz ou vapeurs à respirer
6.
SYSTEMS FOR MONITORING AND APPLYING ELECTRICAL CURRENTS IN AN ORGAN PERFUSION SYSTEM
The disclosure provides for electrode systems and perfusion systems that may be configured to measure the electrical activity of an explanted heart and to provide defibrillation energy as necessary. The perfusion systems may maintain the heart in a beating state at, or near, normal physiological conditions; circulate oxygenated, nutrient enriched perfusion fluid to the heart at or near physiological temperature, pressure, and/or flow rate. These systems may include a pair of electrodes that may be placed epicardially on the right atrium and/or left ventricle of the explanted heart, and/or an electrode placed in the aortic blood path.
A valve assembly includes a conduit comprising a first end and a second end and two control valves. Each valve comprises three ports and a spool for selectively adjusting a proportion of fluid flows through two of the ports. First ports of the valves are for connection with intake or output port of a pump respectively. Second ports of the valves are connected to the second end of the conduit for withdrawing fluid from the conduit or supplying fluid to the conduit respectively. The valve may be included in a ventilator to control the application of variable pressure to exterior surface of a lung in a sealed chamber to cause the lung to breathe.
A61M 16/20 - Valves spécialement adaptées aux dispositifs respiratoires médicaux
F16K 11/07 - Soupapes ou clapets à voies multiples, p.ex. clapets mélangeurs; Raccords de tuyauteries comportant de tels clapets ou soupapes; Aménagement d'obturateurs et de voies d'écoulement spécialement conçu pour mélanger les fluides dont toutes les faces d'obturation se déplacent comme un tout comportant uniquement des tiroirs à éléments de fermeture glissant linéairement à glissières cylindriques
F15B 13/04 - Dispositifs de distribution ou d'alimentation du fluide caractérisés par leur adaptation à la commande de servomoteurs pour utilisation avec un servomoteur unique
F16K 27/04 - Structures des logements; Matériaux utilisés à cet effet des tiroirs
8.
ORGAN CARE SOLUTION FOR EX-VIVO MACHINE PERFUSION OF DONOR LUNGS
An ex-vivo lung solution for machine perfusion of donor lungs on OCS. The solution may be mixed with whole blood or packed red blood cells to form the OCS lung perfusion solution.
The disclosure, in various embodiments, provides systems, methods, and solutions for perfusing an organ. The present application describes illustrative methods for perfusing an ex-vivo organ in a functioning state under physiological or near physiological conditions, including receiving an ex-vivo organ in an organ care system, the ex-vivo organ coupled to a perfusion circuit, infusing a solution into the system, combining the solution with a perfusion fluid to create a mixed solution, pumping the mixed solution to the ex-vivo organ, and receiving the mixed solution from the ex-vivo organ.
In a method of ventilating excised lungs, a ventilation gas is supplied to an airway of a lung and a vacuum is formed around the lung. A quality of the vacuum is varied between a lower level and a higher level to cause the lung to breathe, while the pressure of the ventilation gas supplied to the airway is regulated to maintain a positive airway pressure in the airway of the lung. The vacuum may be cyclically varied between the two vacuum levels. The levels may be maintained substantially constant over a period of time, or one or both of the lower and higher levels may be adjusted during ventilation. The lung may be placed in a sealed chamber, and a vacuum is formed in the chamber around the lung.
The invention provides, in various embodiments, a method comprising placing an ex-vivo heart in a chamber of an organ care system; connecting the ex-vivo heart to a perfusion fluid circuit of the organ care system; starting a pump configured to provide, via the perfusion fluid circuit, a perfusion fluid to the ex-vivo heart; synchronizing at least one maximum output of the pump with an r-wave of the ex-vivo heart; testing the ex-vivo heart or the organ care system; adjusting a setting of the organ care system in response to a result of the testing; and after adjusting the setting of the organ care system in response to the result of the testing, re-testing the ex-vivo heart or the organ care system.
The disclosure provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the disclosure relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes, for example, a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate, for example, the: 1) overall perfusion status of an isolated heart; 2) metabolic status of an isolated heart; and 3) overall vascular patency of an isolated donor heart. This aspect of the present disclosure may use, for example, the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.
09 - Appareils et instruments scientifiques et électriques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Computer programs, downloadable computer programs and
downloadable mobile device software for use in case
management for assigning surgical and clinical resources to
transplant cases, for tracking and reporting on numbers of
transplant cases, for monitoring and tracking status of
organs on journey from donors to recipients, and for
communicating with team members on case logistics. Providing non-downloadable computer software for use in case
management for assigning surgical and clinical resources to
transplant cases, for tracking and reporting on numbers of
transplant cases, for monitoring and tracking status of
organs on journey from donors to recipients, and for
communicating with team members on case logistics.
14.
Apparatus and method for ex vivo lung ventilation with a varying exterior pressure
In a method of ventilating excised lungs, a ventilation gas is supplied to an airway of a lung and a vacuum is formed around the lung. A quality of the vacuum is varied between a lower level and a higher level to cause the lung to breathe, while the pressure of the ventilation gas supplied to the airway is regulated to maintain a positive airway pressure in the airway of the lung. The vacuum may be cyclically varied between the two vacuum levels. The levels may be maintained substantially constant over a period of time, or one or both of the lower and higher levels may be adjusted during ventilation. The lung may be placed in a sealed chamber, and a vacuum is formed in the chamber around the lung.
An ex-vivo lung solution for machine perfusion of donor lungs on OCS. The solution may be mixed with whole blood or packed red blood cells to form the OCS lung perfusion solution.
09 - Appareils et instruments scientifiques et électriques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Recorded computer programs, downloadable computer programs and downloadable mobile device software for use in case management for assigning surgical and clinical resources to transplant cases, for tracking and reporting on numbers of transplant cases, for monitoring and tracking status of organs on journey from donors to recipients, and for communicating with team members on case logistics Providing temporary use of non-downloadable computer software for use in case management for assigning surgical and clinical resources to transplant cases, for tracking and reporting on numbers of transplant cases, for monitoring and tracking status of organs on journey from donors to recipients, and for communicating with team members on case logistics
The disclosure generally relates to a system for perfusing an ex-vivo liver including a pump configured to pump a perfusion fluid through a perfusion circuit, the pump in fluid communication with a hepatic artery interface and a portal vein interface; an oxygenator; a heater; an inferior vena cava interface in fluid communication with an inferior vena cava of the ex-vivo liver; and a reservoir configured to receive the perfusion fluid from the inferior vena cava of the ex-vivo liver and store a volume of fluid.
The disclosure provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the disclosure relates to maintaining an organ ex-vivo at near physiologic conditions. In certain embodiments, the disclosure relates to testing properties of an ex-vivo heart or an organ care system, adjusting a property of the organ care system in response to certain results of the testing, and re-testing the ex-vivo heart or the organ care system. In certain embodiments, the disclosure relates to synchronizing at least one cycle of a pumping of a perfusion fluid with a state of the ex-vivo heart.
The invention generally relates to systems, methods, and devices for ex vivo organ care. More particularly, in various embodiments, the invention relates to caring for a liver ex vivo at physiologic or near-physiologic conditions.
An apparatus, a system, and methods for receiving, perfusing and maintaining and assessing excised donor heart physiological functionality. The system generally comprises an apparatus for receiving and holding an excised heart that is interconnected with: (i) a perfusate-processing system, (ii) a bi-directional perfusate pumping system, (iii) flow sensors for monitoring the flow of perfusate to and from an installed heart's aorta, pulmonary artery, pulmonary vein, and vena cava, (iv) an ECG apparatus interconnectable with the installed heart, and (v) probes interconnecting the installed heart with instruments for monitoring the heart's physiological functionality using load independent indices and load dependent indices.
Apparatus for perfusion of multiple types of organs include base unit configured to removably couple with a perfusion module for perfusing an organ. The base unit has conduits for connecting a source of a perfusate to the organ to circulate the perfusate through the organ; first and second pumps coupled to the conduits for driving circulation of the perfusate in the conduits; and a controller configured and connected for controlling the first and second pumps to regulate the circulation of the perfusate through the organ. The controller is operable to control the first and second pumps to perfuse the organ in accordance with organ specific perfusion parameters. The organ specific perfusions parameters are selected based on the type of the organ, and may be selected by an operator for at least two organ types selected from the group of heart, liver, kidney and lung.
The invention provides, in various embodiments, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to aortic cannulas for use in perfusion systems to return perfusate to the heart or delivering perfusate from the heart while the organ is sustained ex vivo at physiologic or near-physiologic conditions.
In a method of ventilating excised lungs, a ventilation gas is supplied to an airway of a lung and a vacuum is formed around the lung. A quality of the vacuum is varied between a lower level and a higher level to cause the lung to breathe, while the pressure of the ventilation gas supplied to the airway is regulated to maintain a positive airway pressure in the airway of the lung. The vacuum may be cyclically varied between the two vacuum levels. The levels may be maintained substantially constant over a period of time, or one or both of the lower and higher levels may be adjusted during ventilation. The lung may be placed in a sealed chamber, and a vacuum is formed in the chamber around the lung.
Disclosed is a device for supporting and connecting an excised organ (such as a heart, a pair of lungs, a kidney, or a liver) during ex vivo perfusion. The device includes a resilient and flexible sheet having a first portion for contacting and supporting the organ thereon, and a second portion comprising an opening for forming a connection between the organ and a conduit to allow fluid communication between the conduit and the organ. The device also includes a magnetic material embedded in the second portion of the sheet for magnetically securing the connection between the conduit and the organ.
Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.
2+) in the solution is from 0.18 to 0.26 mmol/L, and the pH is lower than 7.4 and higher than 6.6. A composition for preparing the solution may comprise adenosine, lidocaine, and a calcium source, wherein the molar ratio of adenosine:calcium is from 0.3:0.26 to 0.45:0.18, and the molar ratio of lidocaine:calcium is from 0.04:0.26 to 0.09:0.18. A donor heart may be reperfused with the solution. The solution may be used for reperfusion of a donor heart, such as at a temperature from about 25 to about 37° C. The donor may be a donor after circulatory death.
A61K 31/167 - Amides, p.ex. acides hydroxamiques ayant des cycles aromatiques, p.ex. colchicine, aténolol, progabide ayant l'atome d'azote d'un groupe carboxamide lié directement au cycle aromatique, p.ex. lidocaïne, paracétamol
28.
Apparatus for testing, assessment, and maintenance of harvested hearts for transplanting
An apparatus, a system, and methods for receiving, perfusing and maintaining and assessing excised donor heart physiological functionality. The system generally comprises an apparatus for receiving and holding an excised heart that is interconnected with: (i) a perfusate-processing system, (ii) a bi-directional perfusate pumping system, (iii) flow sensors for monitoring the flow of perfusate to and from an installed heart's aorta, pulmonary artery, pulmonary vein, and vena cava, (iv) an ECG apparatus interconnectable with the installed heart, and (v) probes interconnecting the installed heart with instruments for monitoring the heart's physiogical functionality using load independent indices and load dependent indices.
Medical apparatus and instruments for organ perfusion and reperfusion; medical devices for preserving human organs awaiting transplantation; portable medical devices for preserving human organs awaiting transplantation; medical devices for assessing viability of human organs awaiting transplantation; portable medical devices for assessing viability of human organs awaiting transplantation; medical devices for resuscitating human organs for organ transplantation; portable medical devices for resuscitating human organs for organ transplantation; medical apparatus and instruments for use in organ transplant; medical apparatus and instruments for resuscitation, preservation, and assessment of explanted organs; medical apparatus and instruments for resuscitation, preservation, and assessment of explanted organs, namely, hearts, lungs, livers and kidneys; heart monitors; medical ventilators; medical respirators; respirators; respirators for artificial respiration; resuscitators; magnetic connectors for medical purposes; pumps for medical purposes; pumps for medical purposes, namely, pumps for controllably circulating fluids and solutions through explanted organs, and pumps for use in perfusion circuits; perfusion pumps; valves for pumps used in the field of organ perfusion, reperfusion, preservation and transplantation; surgical and medical apparatus and instruments for assessment and transplant of organs; surgical and medical apparatus and instruments for perfusion and reperfusion of organs with fluid for the purpose of preservation, maintenance, assessment and resuscitation; portable organ preservation and transportation systems comprising an organ chamber, perfusion circuit, temperature control means, oxygenation means, and flow control means; organ chambers and perfusion circuits for use in portable organ preservation systems.
30.
Systems for monitoring and applying electrical currents in an organ perfusion system
Electrode systems have been developed for use in perfusion systems to measure the electrical activity of an explanted heart and to provide defibrillation energy as necessary. The perfusion systems maintain the heart in a beating state at, or near, normal physiological conditions; circulating oxygenated, nutrient enriched perfusion fluid to the heart at or near physiological temperature, pressure and flow rate. These systems include a pair of electrodes that are placed epicardially on the right atrium and left ventricle of the explanted heart, as well as an electrode placed in the aortic blood path.
The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.
An organ care system including a blood product heater that includes a heater inlet, a channel, and a heater outlet, wherein the heater inlet includes an inside cross-sectional area and an inside cross-sectional shape configured to flow a blood product into the blood product heater, wherein the heater outlet comprises an inside cross-sectional area and an inside cross-sectional shape configured to flow the blood product out of the blood product heater, and wherein the channel extends between the heater inlet and the heater outlet and is formed between a first flow channel plate and a second flow channel plate; and a first heater thermally coupled to the first flow channel plate configured to heat the first flow channel plate; and a pump configured to circulate a heated blood product to an organ being preserved.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
37 - Services de construction; extraction minière; installation et réparation
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
(1) Medical preparations and solutions for use in organ transplantation; medical preparations and solutions for preserving human organs awaiting transplantation; chemical preparations and solutions for perfusion and reperfusion of explanted organs, and for transport, storage, managing, assessment and treatment of tissues and organs; cardioplegic solutions; cardioplegic solutions used in cardiac surgery; organ perfusion solutions; solutions for resuscitation, perfusion, preservation, assessment, evaluation, transportation, and storage of explanted organs following explant and prior to transplant into a recipient; chemical solutions for organ perfusion, reperfusion, preservation, maintenance, evaluation and resuscitation; solutions for resuscitation, preservation, and assessment of explanted organs, namely, hearts, lungs, livers and kidneys; blood substitutes; blood plasma substitutes; blood substitutes and blood plasma substitutes for medical purposes, namely, for use in the resuscitation, preservation, and assessment of explanted organs; solutions for medical purposes, namely, perfusion solutions for perfusion of ex vivo organs, tissues and cells; sterile and non-toxic solutions for in-vitro perfusion, preservation, assessment, transportation, and storage of explanted organs following explant and prior to transplant into a recipient; organ preservation solutions; solutions for use in heart transplantation; solutions for use in lung transplantation; solutions for use in kidney transplantation; solutions for use in liver transplantation
(2) Medical apparatus and instruments for organ perfusion and reperfusion; medical devices for preserving human organs awaiting transplantation; portable medical devices for preserving human organs awaiting transplantation; medical devices for assessing viability of human organs awaiting transplantation; portable medical devices for assessing viability of human organs awaiting transplantation; medical devices for resuscitating human organs for organ transplantation; portable medical devices for resuscitating human organs for organ transplantation; medical apparatus and instruments for use in organ transplant; medical apparatus and instruments for resuscitation, preservation, and assessment of explanted organs; medical apparatus and instruments for resuscitation, preservation, and assessment of explanted organs, namely, hearts, lungs, livers and kidneys; heart monitors; medical ventilators; medical respirators; respirators; respirators for artificial respiration; resuscitators; magnetic connectors for medical purposes; pumps for medical purposes; pumps for medical purposes, namely, pumps for controllably circulating fluids and solutions through explanted organs, and pumps for use in perfusion circuits; perfusion pumps; valves for pumps used in the field of organ perfusion, reperfusion, preservation and transplantation; surgical and medical apparatus and instruments for assessment and transplant of organs; surgical and medical apparatus and instruments for perfusion and reperfusion of organs with fluid for the purpose of preservation, maintenance, assessment and resuscitation; portable organ preservation and transportation systems comprising an organ chamber, perfusion circuit, temperature control means, oxygenation means, and flow control means; organ chambers and perfusion circuits for use in portable organ preservation systems (1) Installation, maintenance and repair of medical and surgical devices, apparatus and instruments; Installation, maintenance and repair of medical and surgical devices, apparatus and instruments in the field of preservation, maintenance, assessment and resuscitation of organs
(2) Conducting medical training in the use of medical and surgical devices; providing training in the use of surgical and medical apparatus and instruments in the field of preservation, maintenance, assessment and resuscitation of organs
(3) Medical research; medical research laboratory services; research and development in the field of organ donation and transplantation; design and development of medical and surgical products, apparatus, equipment, instruments and preparations, and advisory services thereto; consultation services in the selection, purchase and use of medical and surgical instruments and equipment; scientific and medical research and design relating thereto; scientific research for medical purposes in the field of preservation, maintenance, assessment and resuscitation of organs
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
37 - Services de construction; extraction minière; installation et réparation
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
(1) Medical preparations and solutions for use in organ transplantation; medical preparations and solutions for preserving human organs awaiting transplantation; chemical preparations and solutions for perfusion and reperfusion of explanted organs, and for transport, storage, managing, assessment and treatment of tissues and organs; cardioplegic solutions; cardioplegic solutions used in cardiac surgery; organ perfusion solutions; solutions for resuscitation, perfusion, preservation, assessment, evaluation, transportation, and storage of explanted organs following explant and prior to transplant into a recipient; chemical solutions for organ perfusion, reperfusion, preservation, maintenance, evaluation and resuscitation; solutions for resuscitation, preservation, and assessment of explanted organs, namely, hearts, lungs, livers and kidneys; blood substitutes; blood plasma substitutes; blood substitutes and blood plasma substitutes for medical purposes, namely, for use in the resuscitation, preservation, and assessment of explanted organs; solutions for medical purposes, namely, perfusion solutions for perfusion of ex vivo organs, tissues and cells; sterile and non-toxic solutions for in-vitro perfusion, preservation, assessment, transportation, and storage of explanted organs following explant and prior to transplant into a recipient; organ preservation solutions; solutions for use in heart transplantation; solutions for use in lung transplantation; solutions for use in kidney transplantation; solutions for use in liver transplantation
(2) Medical apparatus and instruments for organ perfusion and reperfusion; medical devices for preserving human organs awaiting transplantation; portable medical devices for preserving human organs awaiting transplantation; medical devices for assessing viability of human organs awaiting transplantation; portable medical devices for assessing viability of human organs awaiting transplantation; medical devices for resuscitating human organs for organ transplantation; portable medical devices for resuscitating human organs for organ transplantation; medical apparatus and instruments for use in organ transplant; medical apparatus and instruments for resuscitation, preservation, and assessment of explanted organs; medical apparatus and instruments for resuscitation, preservation, and assessment of explanted organs, namely, hearts, lungs, livers and kidneys; heart monitors; medical ventilators; medical respirators; respirators; respirators for artificial respiration; resuscitators; magnetic connectors for medical purposes; pumps for medical purposes; pumps for medical purposes, namely, pumps for controllably circulating fluids and solutions through explanted organs, and pumps for use in perfusion circuits; perfusion pumps; valves for pumps used in the field of organ perfusion, reperfusion, preservation and transplantation; surgical and medical apparatus and instruments for assessment and transplant of organs; surgical and medical apparatus and instruments for perfusion and reperfusion of organs with fluid for the purpose of preservation, maintenance, assessment and resuscitation; portable organ preservation and transportation systems comprising an organ chamber, perfusion circuit, temperature control means, oxygenation means, and flow control means; organ chambers and perfusion circuits for use in portable organ preservation systems (1) Installation, maintenance and repair of medical and surgical devices, apparatus and instruments; Installation, maintenance and repair of medical and surgical devices, apparatus and instruments in the field of preservation, maintenance, assessment and resuscitation of organs
(2) Conducting medical training in the use of medical and surgical devices; providing training in the use of surgical and medical apparatus and instruments in the field of preservation, maintenance, assessment and resuscitation of organs
(3) Medical research; medical research laboratory services; research and development in the field of organ donation and transplantation; design and development of medical and surgical products, apparatus, equipment, instruments and preparations, and advisory services thereto; consultation services in the selection, purchase and use of medical and surgical instruments and equipment; scientific and medical research and design relating thereto; scientific research for medical purposes in the field of preservation, maintenance, assessment and resuscitation of organs
CA 03080411 2020-04-27 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 111111 1 11111111 111111 1 11 11111 1 111 11111 1 11 11111 11111 111 111111111 1111 11111111111 1 111111 International Bureau (10) International Publication Number (43) International Publication Date WO 2019/095079 Al 23 May 2019 (23.05.2019) WIPO I PCT (51) International Patent Classification: (74) Agent: SMART & BIGGAR; ATTN: James Pan, AO/NI/02 (2006.01) A61J 1/00 (2006.01) 1100-150 York St., Toronto, Ontario M5H 3S5 (CA). (21) International Application Number: (81) Designated States (unless otherwise indicated, for every PCT/CA2018/051474 kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (22) International Filing Date: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, 20 November 2018 (20.11.2018) DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (25) Filing Language: English HR, HU, ED, EL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, (26) Publication Language: English MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (30) Priority Data: OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, 62/588,727 20 November 2017 (20.11.2017) US SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (71) Applicant: TEVOSOL, INC. [CA/CA]; 4261 TEC Centre, 10230 Jasper Avenue, Edmonton, Alberta T5J 4P6 (CA). (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (72) Inventor: FREED, Darren; c/o University of Alberta Hos- GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, pital, Div. of Cardiac Surgery - 2D4.34 WMC, 8440-112 UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, St., Edmonton, Alberta T6G 2B7 (CA). TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, EE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (54) Title: APPARATUS FOR PERFUSION OF AN EXCISED ORGAN 290 200 280 1002 262 202 864 . . 976 290 -8424 290 = 222 966 224 292 226 290 4!C FIG. 2B Itcp(57) Abstract: Disclosed is a device for supporting and connecting an excised organ (such as a heart, a pair of lungs, a kidney, or a liver) during ex vivo perfusion. The device includes a resilient and flexible sheet having a first portion for contacting and supporting the organ thereon, and a second portion comprising an opening for forming a connection between the organ and a conduit to allow fluid communication between the conduit and the organ. The device also includes a magnetic material embedded in the second portion of the sheet for magnetically securing the connection between the conduit and the organ. [Continued on next page] CA 03080411 2020-04-27 WO 2019/095079 Al I11111 RINI II lIllIl 11111 11111 3E111 I 00111111 11111 TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: ¨ with international search report (Art. 21(3))
The invention provides, in various embodiments, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to aortic cannulas for use in perfusion systems to return perfusate to the heart or delivering perfusate from the heart while the organ is sustained ex vivo at physiologic or near-physiologic conditions.
The invention generally relates to systems, methods, and devices for ex vivo organ care. More particularly, in various embodiments, the invention relates to caring for a liver ex vivo at physiologic or near-physiologic conditions.
A61M 37/00 - Autres appareils pour introduire des agents dans le corps; Percutanisation, c. à d. introduction de médicaments dans le corps par diffusion à travers la peau
C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus
39.
Composition and solution with controlled calcium ion level, and related method and use for reperfusion
2+) in the solution is from 0.18 to 0.26 mmol/L, and the pH is lower than 7.4 and higher than 6.6. A composition for preparing the solution may comprise adenosine, lidocaine, and a calcium source, wherein the molar ratio of adenosine:calcium is from 0.3:0.26 to 0.45:0.18, and the molar ratio of lidocaine:calcium is from 0.04:0.26 to 0.09:0.18. A donor heart may be reperfused with the solution. The solution may be used for reperfusion of a donor heart, such as at a temperature from about 25 to about 37° C. The donor may be a donor after circulatory death.
A61K 31/167 - Amides, p.ex. acides hydroxamiques ayant des cycles aromatiques, p.ex. colchicine, aténolol, progabide ayant l'atome d'azote d'un groupe carboxamide lié directement au cycle aromatique, p.ex. lidocaïne, paracétamol
The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.
The present disclosure relates to a method of ventilating excised lungs. A ventilation gas is supplied to an airway of a lung and a vacuum is formed around the lung. A quality of the vacuum is varied between a lower level and a higher level to cause the lung to breathe, while the pressure of the ventilation gas supplied to the airway is regulated to maintain a positive airway pressure in the airway of the lung. The vacuum may be cyclically varied between the two vacuum levels. The levels may be maintained substantially constant over a period of time, or one or both of the lower and higher levels may be adjusted during ventilation. The lung may be placed in a sealed chamber, and a vacuum is formed in the chamber around the lung.
Apparatus for perfusion of multiple types of organs include base unit configured to removably couple with a perfusion module for perfusing an organ. The base unit has conduits for connecting a source of a perfusate to the organ to circulate the perfusate through the organ; first and second pumps coupled to the conduits for driving circulation of the perfusate in the conduits; and a controller configured and connected for controlling the first and second pumps to regulate the circulation of the perfusate through the organ. The controller is operable to control the first and second pumps to perfuse the organ in accordance with organ specific perfusion parameters. The organ specific perfusions parameters are selected based on the type of the organ, and may be selected by an operator for at least two organ types selected from the group of heart, liver, kidney and lung.
An apparatus, a system, and methods for receiving, perfusing and maintaining and assessing excised donor heart physiological functionality. The system generally comprises an apparatus for receiving and holding an excised heart that is interconnected with: (i) a perfusate-processing system, (ii) a bi-directional perfusate pumping system, (iii) flow sensors for monitoring the flow of perfusate to and from an installed heart's aorta, pulmonary artery, pulmonary vein, and vena cava, (iv) an ECG apparatus interconnectable with the installed heart, and (v) probes interconnecting the installed heart with instruments for monitoring the heart's physiogical functionality using load independent indices and load dependent indices.
An apparatus, a system, and methods for maintaining and monitoring an excized donor heart. The apparatus comprises a first component for receiving and submerging therein an excized heart in a constantly circulating perfusate solution and a second component comprising equipment for adjusting the temperature and oxygen content of the perfusate solution. The first component comprises an integral pair of defibrillating pads. A first conduit infrastructure interconnects the first module, the second module and an aorta of the excized donor heart pushing a perfusion solution from the first module through the second module into the aorta. The second conduit infrastructure connects the first module with the right atrium and the left atrium for pushing the perfusion solution from the first module into the atria. The third conduit infrastructure connects the first module with the pulmonary artery and provides an after pressure to the flow of the perfusion solution from the pulmonary artery.
An aortic cannula for use in an ex-vivo organ care system. The aortic cannula includes a cannula body. The cannula body includes a fitting adapted to connect to an ex-vivo organ care system; and an aorta interface configured to contact an aorta. The aortic cannula includes a pivot arm comprising a pivot arm strap, and the pivot arm strap is operably connected to a pivot mount, and the pivot mount is configured to allow the pivot arm strap to contact the aorta to hold the aorta on the aorta interface. The aortic cannula includes a spring configured to apply a pressure to the pivot arm strap to hold the aorta on the aorta interface.
The invention provides, in various embodiments, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to aortic cannulas for use in perfusion systems to return perfusate to the heart or delivering perfusate from the heart while the organ is sustained ex vivo at physiologic or near-physiologic conditions.
The invention provides, in various embodiments, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to aortic cannulas for use in perfusion systems to return perfusate to the heart or delivering perfusate from the heart while the organ is sustained ex vivo at physiologic or near-physiologic conditions.
−4 mmol/L; and a pH of 6.9. The oxygenated cardioplegic composition is pre-warmed to about 35° C. and then used for immediate reperfusion of a donor heart for at least three minutes after its procurement.
Electrode systems have been developed for use in perfusion systems to measure the electrical activity of an explanted heart and to provide defibrillation energy as necessary. The perfusion systems maintain the heart in a heating state at, or near, normal physiological conditions; circulating oxygenated, nutrient enriched perfusion fluid to the heart at or near physiological temperature, pressure and flow rate. These systems include a pair of electrodes that are placed epicardially on the right atrium and left ventricle of the explanted heart, as well as an electrode placed in the aortic blood path.
Apparatus for perfusion of multiple types of organs include base unit configured to removably couple with a perfusion module for perfusing an organ. The base unit has conduits for connecting a source of a perfusate to the organ to circulate the perfusate through the organ; first and second pumps coupled to the conduits for driving circulation of the perfusate in the conduits; and a controller configured and connected for controlling the first and second pumps to regulate the circulation of the perfusate through the organ. The controller is operable to control the first and second pumps to perfuse the organ in accordance with organ specific perfusion parameters. The organ specific perfusions parameters are selected based on the type of the organ, and may be selected by an operator for at least two organ types selected from the group of heart, liver, kidney and lung.
Apparatus for perfusion of multiple types of organs include base unit configured to removably couple with a perfusion module for perfusing an organ. The base unit has conduits for connecting a source of a perfusate to the organ to circulate the perfusate through the organ; first and second pumps coupled to the conduits for driving circulation of the perfusate in the conduits; and a controller configured and connected for controlling the first and second pumps to regulate the circulation of the perfusate through the organ. The controller is operable to control the first and second pumps to perfuse the organ in accordance with organ specific perfusion parameters. The organ specific perfusions parameters are selected based on the type of the organ, and may be selected by an operator for at least two organ types selected from the group of heart, liver, kidney and lung.
A solution comprises a preservation mixture comprising a calcium ion source; and a buffer for maintaining a pH of the solution. The molar concentration of calcium ion (Ca2+) in the solution is from 0.18 to 0.26 mmol/L, and the pH is lower than 7.4 and higher than 6.6. A composition for preparing the solution may comprise adenosine, lidocaine, and a calcium source, wherein the molar ratio of adenosine:calcium is from 0.3:0.26 to 0.45:0.18, and the molar ratio of lidocaine:calcium is from 0.04:0.26 to 0.09:0.18. A donor heart may be reperfused with the solution. The solution may be used for reperfusion of a donor heart, such as at a temperature from about 25 to about 37 °C. The donor may be a donor after circulatory death.
The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.
The invention generally relates to systems, methods, and devices for ex vivo organ care. More particularly, in various embodiments, the invention relates to caring for a liver ex vivo at physiologic or near-physiologic conditions. Other embodiments of the disclosed subject matter are possible. Embodiments of the disclosed subject matter can provide techniques relating to portable ex vivo organ care, such as ex vivo liver organ care. In some embodiments, the liver care system can maintain the liver at, or near, normal physiological conditions. To this end, the system can circulate an oxygenated, nutrient enriched perfusion fluid to the liver at or near physiological temperature, pressure, and flow rate.
A61M 1/00 - Dispositifs de succion ou de pompage à usage médical; Dispositifs pour retirer, traiter ou transporter les liquides du corps; Systèmes de drainage
The invention generally relates to systems, methods, and devices for ex vivo organ care. More particularly, in various embodiment, the invention relates to caring for a liver ex vivo at physiologic or near-physiologic conditions. The below summary is exemplary only, and not limiting. Other embodiment of the disclosed subject matter are possible. Embodiment of the disclosed subject matter can provide techniques relating to portable ex vivo organ care, such as ex vivo liver organ care. In some embodiment, the liver care system can maintain the liver at, or near, normal physiological conditions. To this end, the system can circulate an oxygenated, nutrient enriched perfusion fluid to the liver at or near physiological temperature, pressure, and flow rate.
A61M 1/00 - Dispositifs de succion ou de pompage à usage médical; Dispositifs pour retirer, traiter ou transporter les liquides du corps; Systèmes de drainage
The invention generally relates to systems, methods, and devices for ex vivo organ care. More particularly, in various embodiment, the invention relates to caring for a liver ex vivo at physiologic or near-physiologic conditions. The below summary is exemplary only, and not limiting. Other embodiment of the disclosed subject matter are possible. Embodiment of the disclosed subject matter can provide techniques relating to portable ex vivo organ care, such as ex vivo liver organ care. In some embodiment, the liver care system can maintain the liver at, or near, normal physiological conditions. To this end, the system can circulate an oxygenated, nutrient enriched perfusion fluid to the liver at or near physiological temperature, pressure, and flow rate.
The invention generally relates to systems, methods, and devices for ex vivo organ care. More particularly, in various embodiments, the invention relates to caring for a liver ex vivo at physiologic or near-physiologic conditions.
An apparatus, a system, and methods for maintaining and monitoring an excised donor heart. The apparatus comprises a first component for receiving and submerging therein an excised heart in a constantly circulating perfusate solution and a second component comprising equipment for adjusting the temperature and oxygen content of the perfusate solution. The first component comprises an integral pair of defibrillating pads. A first conduit infrastructure interconnects the first module, the second module and an aorta of the excised donor heart pushing a perfusion solution from the first module through the second module into the aorta. The second conduit infrastructure connects the first module with the right atrium and the left atrium for pushing the perfusion solution from the first module into the atria. The third conduit infrastructure connects the first module with the pulmonary artery and provides an after pressure to the flow of the perfusion solution from the pulmonary artery.
An apparatus, a system, and methods for maintaining and monitoring an excised donor heart. The apparatus comprises a first component for receiving and submerging therein an excised heart in a constantly circulating perfusate solution and a second component comprising equipment for adjusting the temperature and oxygen content of the perfusate solution. The first component comprises an integral pair of defibrillating pads. A first conduit infrastructure interconnects the first module, the second module and an aorta of the excised donor heart pushing a perfusion solution from the first module through the second module into the aorta. The second conduit infrastructure connects the first module with the right atrium and the left atrium for pushing the perfusion solution from the first module into the atria. The third conduit infrastructure connects the first module with the pulmonary artery and provides an after pressure to the flow of the perfusion solution from the pulmonary artery.
directional perfusate pumping system, (in) flow sensors for monitoring the flow of perfusate to and from an installed heart's aorta, pulmonary artery, pulmonary vein, and vena cava, (iv) an ECG apparatus interconnectable with the installed heart, and (v) probes interconnecting the installed heart with instruments for monitoring the heart's physiogical functionality using load independent indices and load dependent indices.
An apparatus, a system, and methods for receiving, perfusing and maintaining and assessing excised donor heart physiological functionality, The system generally comprises an apparatus for receiving and holding an excised heart that is interconnected with: (i) a perfusate-processing system, (ii) a bi¬ directional perfusate pumping system, (in) flow sensors for monitoring the flow of perfusate to and from an installed heart's aorta, pulmonary artery, pulmonary vein, and vena cava, (iv) an ECG apparatus interconnectable with the installed heart, and (v) probes interconnecting the installed heart with instruments for monitoring the heart's physiogical functionality using load independent indices and load dependent indices.
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaire; Accessoires à cet effet, p.ex. dispositifs de remplissage ou de nettoyage, appuis-bras
Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.
An ex-vivo lung solution for machine perfusion of donor lungs on OCS. The solution may be mixed with whole blood or packed red blood cells to form the OCS lung perfusion solution.
An ex-vivo lung solution for machine perfusion of donor lungs on OCS. The solution may be mixed with whole blood or packed red blood cells to form the OCS lung perfusion solution.
An ex-vivo lung solution for machine perfusion of donor lungs on OCS. The solution may be mixed with whole blood or packed red blood cells to form the OCS lung perfusion solution.
An ex-vivo lung solution for machine perfusion of donor lungs on OCS. The solution may be mixed with whole blood or packed red blood cells to form the OCS lung perfusion solution.
A61B 19/00 - Instruments, outillage ou accessoires pour la chirurgie ou le diagnostic non couverts par l'un des groupes A61B 1/00-A61B 18/00, p.ex. pour stéréotaxie, opération aseptique, traitement de la luxation, protecteurs des bords des blessures(masques de protection du visage A41D 13/11; blouses de chirurgien ou vêtements pour malades A41D 13/12; dispositifs pour retirer, traiter ou transporter les liquides du corps A61M 1/00)
A61M 16/00 - Dispositifs pour agir sur le système respiratoire des patients par un traitement au gaz, p.ex. bouche-à-bouche; Tubes trachéaux
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
10 - Appareils et instruments médicaux
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
(1) Chemical solutions for organ preservation, maintenance, evaluation and resuscitation.
(2) Portable organ preservation systems comprising an organ chamber, perfusion circuit, temperature control means, oxygenation means, and flow control means; and Organ chambers and Perfusion circuits for use in portable organ preservation systems. (1) Training and instructional services in connection with the use of portable organ preservation systems.
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
G01N 33/53 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet
G01N 33/567 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet utilisant un support spécifique ou des protéines réceptrices comme réactifs pour la formation de liaisons par ligand utilisant un extrait de tissu ou d'organe comme agent de liaison
A61M 16/00 - Dispositifs pour agir sur le système respiratoire des patients par un traitement au gaz, p.ex. bouche-à-bouche; Tubes trachéaux
A61M 16/10 - Préparation de gaz ou vapeurs à respirer
A61M 11/00 - Pulvérisateurs ou vaporisateurs spécialement destinés à des usages médicaux
Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus
C12Q 1/00 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions
Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus
C12Q 1/00 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions
Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus
C12Q 1/00 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions
Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
C12Q 1/02 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des micro-organismes viables
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex- vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.
The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex- vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.
The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex- vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.
The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex- vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.
Electrode systems have been developed for use in perfusion systems to measure the electrical activity of an explanted heart and to provide defibrillation energy as necessary. The perfusion systems maintain the heart in a beating state at, or near, normal physiological conditions; circulating oxygenated, nutrient enriched perfusion fluid to the heart at or near physiological temperature, pressure and flow rate. These systems include a pair of electrodes that are placed epicardially on the right atrium and left ventricle of the explanted heart, as well as an electrode placed in the aortic blood path.
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p.ex. fermenteurs commandés automatiquement
C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus
A61F 2/00 - Filtres implantables dans les vaisseaux sanguins; Prothèses, c.-à-d. éléments de substitution ou de remplacement pour des parties du corps; Appareils pour les assujettir au corps; Dispositifs maintenant le passage ou évitant l'affaissement de structures corporelles tubulaires, p.ex. stents
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p.ex. fermenteurs commandés automatiquement
The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.
The invention provides systems, methods and solutions for perfusing a lung ex vivo. A method for perfusing a lung ex vivo comprises connecting the lung within a fluid perfusion circuit, flowing a perfusion fluid into the lung through a pulmonary artery interface and away from the lung through a pulmonary vein interface, providing a respiratory gas to the lung for use in metabolism by the lung, the respiratory gas having a pre-determined composition of oxygen, and ventilating the lung through a tracheal interface.
The invention provides systems, methods and solutions for perfusing a lung ex vivo. A method for perfusing a lung ex vivo comprises connecting the lung within a fluid perfusion circuit, flowing a perfusion fluid into the lung through a pulmonary artery interface and away from the lung through a pulmonary vein interface, providing a respiratory gas to the lung for use in metabolism by the lung, the respiratory gas having a pre-determined composition of oxygen, and ventilating the lung through a tracheal interface.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
10 - Appareils et instruments médicaux
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Chemical solutions for organ preservation, maintenance,
evaluation or resuscitation. Portable organ preservation systems comprising an organ
chamber, perfusion circuit, temperature control means,
oxygenation means, and flow control means; organ chambers
and perfusion circuits for use in portable organ
preservation systems. Training and instructional services in connection with the
use of portable organ preservation systems.
95.
Method of timing pulsatile flow of normothermic perfusate to the heart
The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
10 - Appareils et instruments médicaux
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
(1) Chemical solutions for organ preservation, maintenance, evaluation or resuscitation.
(2) Portable organ preservation systems comprising an organ chamber, perfusion circuit, temperature control means, oxygenation means, and flow control means; and organ chambers and perfusion circuits for use in portable organ preservation systems. (1) Training and instructional services in connection with the use of portable organ preservation systems.
Portable organ preservation systems comprising an organ chamber, perfusion circuit, temperature control means, oxygenation means, and flow control means; and organ chambers and perfusion circuits for use in portable organ preservation systems
