Abstract

The prediction of the tumor stage is very difficult and is notably problematic to carry out a proper follow-up of the treatment of the tumor. The Applicant has found a way to circumvent such problem by proposing a computer tool which is adapted to predict the tumor stage of a subject, based on original parameters; a volume of the tumor calculated based on images obtained by one modality, at least one parameter relative to the interaction between a chemical agent and the tumor, and t least one parameter relative to the presence of tumor vessels in a volume containing the tumor.

IPC Classes  ?

• G06T 7/00 - Image analysis

Abstract

In cases of acute and chronic kidney damage, BET (Bromodomain and Extra-Terminal domain) inhibitors, such as the JQ1 molecule, can be used to inhibit the UPR (Unfolded Protein Response) pathway and other inflammatory and pro-fibrotic pathways, thus improving tissue damage and restoring kidney function. Nevertheless, JQ1 exhibits toxicity and low specificity, so that in order to achieve a suitable therapeutic effect, high doses that are incompatible with a low degree of toxicity must be used. The present invention proposes a solution to the poor pharmacokinetic profile of JQ1 and its low oral availability that comprises designing and developing lipid-based nanoparticles that make it possible to encapsulate and selectively administer the JQ1 inhibitor in sufficient quantity to achieve the desired therapeutic effect and at the same time reduce its toxicity.

IPC Classes  ?

• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61P 13/12 - Drugs for disorders of the urinary system of the kidneys

Abstract

The present invention relates to the chemical synthesis and production of compounds derived from imidazo[1,2-a]pyridine of formula I, wherein R2, R3, R5, R6and R7 have the meanings indicated in the description; a method for obtaining same; and the therapeutic use thereof as a pharmaceutical composition for anti-inflammatory use in vitro and in vivo in diseases involving inflammatory and pro-fibrotic processes.

IPC Classes  ?

• C07D 471/04 - Ortho-condensed systems
• A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]

Abstract

Method, product and blocking element of short wavelengths in LED-type light sources consisting of a substrate with a pigment distributed on its surface and, in that said pigment has an optical density such that it allows the selective absorption of short wavelengths between 380 nm and 500 nm in a range between 1 and 99%.

IPC Classes  ?

• G02B 5/22 - Absorbing filters
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
• A61F 2/16 - Intraocular lenses
• G01J 1/02 - Photometry, e.g. photographic exposure meter Details
• G01J 1/42 - Photometry, e.g. photographic exposure meter using electric radiation detectors
• G01J 9/00 - Measuring optical phase differenceDetermining degree of coherenceMeasuring optical wavelength
• G02B 5/20 - Filters
• G02B 19/00 - Condensers
• G09F 9/33 - Indicating arrangements for variable information in which the information is built-up on a support by selection or combination of individual elements in which the desired character or characters are formed by combining individual elements being semiconductor devices, e.g. diodes
• H01L 33/44 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by the coatings, e.g. passivation layer or anti-reflective coating
• H04N 9/64 - Circuits for processing colour signals

Abstract

The invention relates to an optoelectronic device for simultaneously determining the absolute retardance and the rotation angle of the fast eigenstate of an optical retarder (4). The device comprises a light source (1), a polarisation control system (2), an interferometer (3) capable of producing two different polarisation states, a system for rotating the optical retarder (4) to be characterised, a second polarisation control system (5), a photodetection system (6) and a data processing system (7). The invention also relates to methods for simultaneously calculating the absolute retardance and the rotation angle of the fast axis of an optical retarder (4) from measurements of the rotation angle of the retarder (4) and measurements from the photodetection system (6).

IPC Classes  ?

• G01B 9/02 - Interferometers

Abstract

The present disclosure relates to the compounds of formula (I) or their pharmaceutically acceptable salts, or their stereoisomers or mixtures of stereoisomers, either of the compound of formula (I) or of any of its pharmaceutically acceptable salts which are NPM1 inhibitors. It also relates to pharmaceutical compositions containing them, and to their use in medicine, in particular in the treatment and/or prevention of cancer.

IPC Classes  ?

• C07D 209/90 - Benzo [c, d] indolesHydrogenated benzo [c, d] indoles
• A61K 31/403 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
• A61P 35/02 - Antineoplastic agents specific for leukemia

Abstract

The invention relates to a pharmaceutical combination comprising bevacizumab (BVZ) and delta-9-tetrahydrocannabinol (THC) for use in the treatment of glioma, in particular glioblastoma, and a combination comprising bevacizumab (BVZ), temozolomide (TMZ) and the mixture of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in the ratio of 1:1 for use in the treatment of glioma, in particular glioblastoma.

IPC Classes  ?

• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61K 31/53 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention relates to a coagulation factor V-deficient non-human animal model that includes an amino acid replacement in the FV protein that reproduces the human mutation Thr1898Met. In particular, the present invention relates to a mouse animal model, with the mutation located in Thr1857Met of the murine FV protein. The invention includes heterozygous and homozygous mutants for this mutation, producing viable litters and subjects with mild clinical signs of the disease which do not cause the animal to suffer. The present invention further relates, on the one hand, to a method for producing non-human coagulation factor V-deficient animals using gene editing and assisted reproduction techniques using zygote microinjection and, on the other hand, to the use of the animal model in the study of drugs for the treatment of coagulation factor V deficiency.

IPC Classes  ?

• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression

Abstract

The invention relates to a method for obtaining coacervates comprising a polymer and spores of at least one fungus used for the biocontrol of agricultural pests, for use thereof as a tool in the biocontrol of plant diseases and pests, the method comprising the steps of dissolving a polymer in a weak acid buffer, adding spores of at least one fungus used as a biocontrol agent, agitating to obtain a homogenous dispersion, and adding an aqueous solution at a basic pH to the previous solution.

IPC Classes  ?

• A01N 25/28 - Microcapsules
• A01N 63/30 - Microbial fungiSubstances produced thereby or obtained therefrom
• C12N 11/10 - Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
• C12N 1/04 - Preserving or maintaining viable microorganisms
• A01P 5/00 - Nematocides
• C12R 1/165 - Corynebacterium poinsettiae

Abstract

The present invention relates to an in vitro diagnostic method to differentiate African Swine Fever Virus (ASFV) infected animals from animals which have been vaccinated against ASFV using an immunogenic composition comprising an attenuated ASFV in which the EP153R gene and the EP402R gene have been inactivated and wherein the region of the ASFV genome comprising the EP402R and the EP153R genes is replaced by a heterologous gene.

IPC Classes  ?

• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Abstract

The present invention relates to African Swine Fever (ASF) attenuated viruses wherein the genes EP402R and EP153R have been inactivated, which can be used as a vaccine. The attenuated viruses protect pigs against subsequent challenge with virulent virus. The present invention also relates to the use of such attenuated viruses to treat and/or prevent ASF.

IPC Classes  ?

• A61K 39/12 - Viral antigens
• A61P 31/20 - Antivirals for DNA viruses
• C12N 7/04 - Inactivation or attenuationProducing viral sub-units

Abstract

A chemiresistive sensor has a low limit for detecting NO2 at ambient temperature. An active layer of the sensor includes a few-layer graphene material. The response of the sensor is not altered by relative humidity, and the sensor also demonstrates very low interference with ammonia, allowing this interference to be disregarded in the measurements.

IPC Classes  ?

• G01N 27/12 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon absorption of a fluidInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon reaction with a fluid
• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups

Abstract

The present invention relates to a non-human animal model of chronic glaucoma. In addition, the invention refers to a method for the preparation of said animal model, as well as to the use thereof.

IPC Classes  ?

• A01K 67/027 - New or modified breeds of vertebrates
• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61K 31/573 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
• A61K 38/39 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]

Abstract

The present invention refers to a peptide, comprising or consisting of SEQ ID NO: 1 (CAYMTMKIRN), for use as a medicament, preferably in the prevention and/or treatment of cardiac damage arising after ischemia followed by reperfusion, or in the prevention and/or treatment of the inflammatory response following acute myocardial infarction. In a preferred embodiment, the peptide is conjugated with a nanoparticle.

IPC Classes  ?

• A61K 47/62 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61P 9/00 - Drugs for disorders of the cardiovascular system

Abstract

The invention relates to a method for enhancing the osteogenic differentiation of mesenchymal stromal cells (MSCs) by culturing same in an osteogenic medium with an added EphB3-receptor blocking reagent. The blocking reagent may be selected from polyclonal antibodies, monoclonal antibodies, fusion proteins or a combination thereof. The invention also relates to the cells of the osteogenic lineage obtained using the described method and to the EphB3-receptor blocking reagents, for use in the treatment of bone diseases causing bony tissue deficiency and/or bone fractures. The invention also relates to pharmaceutical compositions containing the cells of the osteogenic lineage obtained using the method and/or the EphB3-receptor blocking reagents.

IPC Classes  ?

• C12N 5/077 - Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
• A61K 35/28 - Bone marrowHaematopoietic stem cellsMesenchymal stem cells of any origin, e.g. adipose-derived stem cells

Abstract

The present invention relates to novel water-soluble BODIPY dyes by means of simple boron functionalisation. The known hydrophobicity of BODIPYs and most common analogues thereof represents an important limitation to its optimal use in some applications that require water solubility, meaning that it is of interest to obtain BODIPYs that are soluble in water or in highly hydrophilic media from conventional precursor BODIPYs. The invention relates to the structural design, synthetic access and water solubility of a novel group of hydrophilic molecular dyes belonging to the BODIPY family, which are advantageous due to the generality and ease of obtainment thereof from conventional BODIPY dyes (F-BODIPY-based), said production entailing the minimal disturbance of the photophysical properties of the starting dye, as well as a significant chemical and photophysical robustness, which implies the potential use thereof in photonic, physical and chemical applications in aqueous or highly hydrophilic media.

IPC Classes  ?

• C07F 5/02 - Boron compounds
• C09B 57/00 - Other synthetic dyes of known constitution
• C09K 11/07 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials having chemically-interreactive components, e.g. reactive chemiluminescent compositions
• G03C 1/735 - Organo-metallic compounds

Abstract

Current treatments for surgical site infections that are caused by fungi or bacteria with antibiotics and antifungal agents are usually based on the prolonged intravenous administration or use of polymethyl methacrylate cements after removing the prosthesis and cleaning the surrounding tissue, which requires another surgical procedure. However, an administration system that avoids high body exposure to the antimicrobial agent and prevents the patient from having to undergo a new surgery would be more desirable. The present invention discloses 3D printed implants with biocompatible and biodegradable polymers comprising medicinal drugs with immediate-sustained release, having a reduced haemolytic profile, which easily adhere to the prostheses, exhibit a good in vitro efficacy profile against different fungal and bacterial strains and can be sterilised by means of UV light due to the thinness thereof.

IPC Classes  ?

• A61B 17/56 - Surgical instruments or methods for treatment of bones or jointsDevices specially adapted therefor

Abstract

The present invention relates to compounds of formula (I), in addition to the use thereof for the treatment and/or prevention of diseases caused by protozoa, especially those belonging to the genus Leishmania or Trypanosoma. The present invention likewise relates to pharmaceutical compositions comprising said compounds. (I)

IPC Classes  ?

• A61K 31/4184 - 1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
• A61K 31/4402 - Non-condensed pyridinesHydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
• A61K 31/444 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
• C07D 235/14 - Radicals substituted by nitrogen atoms
• C07D 213/06 - Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom

Abstract

Controlling blood glucose is a difficult task that diabetic people usually need to carry out on their own. An accurate and timely prediction is vital to make decisions and recommend corrective actions. For this reason, there is a need to develop methods for efficiently and accurately predicting the glucose value that enables blood glucose control systems to be implemented safely using simple devices that are comfortable for the patient. The present invention discloses a non-invasive method and system for predicting glucose values, based on the estimation from a number of variables measured with an activity wristband. The system uses variables that are not directly related with glucose to estimate and predict glucose values and it generates warnings in dangerous cases of hypoglycaemia and hyperglycaemia.

IPC Classes  ?

• G16H 50/00 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
• A61B 5/15 - Devices for taking samples of blood
• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders

Abstract

The present disclosure relates to the compounds of formula (I) or their pharmaceutically acceptable salts, or their stereoisomers or mixtures of stereoisomers, either of the compound of formula (I) or of any of its pharmaceutically acceptable salts which are NPM1 inhibitors. It also relates to pharmaceutical compositions containing them, and to their use in medicine, in particular in the treatment and/or prevention of cancer.

IPC Classes  ?

• C07D 209/88 - CarbazolesHydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
• C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 403/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 409/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring- member bond
• A61K 31/40 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
• A61P 35/02 - Antineoplastic agents specific for leukemia

Abstract

The present invention relates to a sensor device that comprises a sensor chip for sensing magnetic fields which has a sensor cell and further comprises a casing made of an encapsulation material, wherein the sensor chip for sensing magnetic fields is arranged and the sensor cell is not covered by the encapsulation material. The sensor device further comprises a layer of biomolecules that are arranged on the sensor cell and wherein said biomolecules are designed to capture a specific genetic or biochemical material present in a sample to then perform the subsequent anchoring of magnetic particles modified with the same capture biomolecules. Thus, the target genetic or biochemical material will be detected by analysing the magnetic field disturbance of the sensor based on the magnetic particles anchored to the surface of the sensor in a manner that is directly proportional to the amount of the target genetic or biochemical material present in the sample.

IPC Classes  ?

• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters

Abstract

The present invention relates to a system for housing laboratory animals, which can be adapted to small animals (mice, rats, hamsters, guinea pigs, gerbils) or medium-size animals (rabbits, ferrets). For small animals, five peripheral trays (2) which each comprise a trough (21) are used, in addition to a separate trough (11). These six structures are arranged radially, thereby providing a central hexagonal tray (1) in communication with the peripheral trays (2) by means of a contact hole (3) located in a central wall (23) of each peripheral tray (2). For medium-size animals, the troughs (21) are eliminated and the separate trough (11) is replaced by a sixth peripheral tray (2). In both cases, the six elements are fitted, by means of bottom flanges, into grooves (61) made in a base plate (6).

IPC Classes  ?

• A01K 1/03 - Housing for domestic or laboratory animals

Abstract

Electronic devices are available on the market with a multitude of forms and applications that essentially supply information from a transmitter/receiver. It is usually necessary for these devices to be linked to other compatible equipment. In order to prevent health problems due to poor posture, it is desirable for these devices to incorporate a simple system which allows the ergonomic posture of both the eyes and the body to be monitored and which does not have to be linked to other devices. The present invention relates to a simple accessory, without connections to other devices, for monitoring the posture of the eyes and body, incorporating accelerometers for calculating the position of the body and vibration sensors as a warning system.

IPC Classes  ?

• A61B 5/103 - Measuring devices for testing the shape, pattern, size or movement of the body or parts thereof, for diagnostic purposes
• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb

Abstract

The present invention refers to the treatment of fungal infections or diseases by using specific affinity reagents, such as nanobodies, which specifically bind the fungal β-1,3- glucanosyltransferase gel4.

IPC Classes  ?

• A61P 31/10 - Antimycotics
• C07K 16/14 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from fungi, algae or lichens

Abstract

A formulation comprising amphotericin B based on collapsed microparticles for administration by inhalation and which additionally comprises oligosaccharides and monosaccharides, as well as amino acids, as excipients, whereby the oligosaccharides and monosaccharides are γ-cyclodextrin and mannose, and the amino acid is leucine. The formulation can be administered using dry powder inhalers or aerosols.

IPC Classes  ?

• A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
• A61K 47/40 - CyclodextrinsDerivatives thereof
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
• A61K 9/72 - Medicinal preparations characterised by special physical form for smoking or inhaling
• A61P 31/10 - Antimycotics

Abstract

Bullet-proof vests consisting of polymeric shielding change their properties over time, as they are subjected to conditions of humidity, temperature, light, body heat, among others. This affects their resistance to the impact of a bullet, and therefore their reliability as protective systems. To discover their deterioration with the passage of time, ageing tests are usually performed under controlled artificial conditions; however, the correlation between natural ageing and accelerated ageing is a highly controversial subject; a method to provide reliable, objective information in real time on the condition of a protective vest would be highly desirable, in order to calculate its reliability and its remaining useful life.

IPC Classes  ?

• F41H 1/00 - Personal protection-gear

Abstract

Method, product and blocking element of short wavelengths in LED-type light sources consisting of a substrate with a pigment distributed on its surface and, in that said pigment has an optical density such that it allows the selective absorption of short wavelengths between 380 nm and 500 nm in a range between 1 and 99%.

IPC Classes  ?

• G02B 5/22 - Absorbing filters
• G01J 1/42 - Photometry, e.g. photographic exposure meter using electric radiation detectors
• G02B 19/00 - Condensers
• H01L 33/44 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by the coatings, e.g. passivation layer or anti-reflective coating
• A61F 2/16 - Intraocular lenses
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G01J 1/02 - Photometry, e.g. photographic exposure meter Details
• H04N 9/64 - Circuits for processing colour signals
• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
• G02B 5/20 - Filters
• G09F 9/33 - Indicating arrangements for variable information in which the information is built-up on a support by selection or combination of individual elements in which the desired character or characters are formed by combining individual elements being semiconductor devices, e.g. diodes
• G01J 9/00 - Measuring optical phase differenceDetermining degree of coherenceMeasuring optical wavelength

Abstract

Meyerozyma guilliermondiiM. guilliermondiiM. guilliermondiiM. guilliermondii.

IPC Classes  ?

• C12N 1/19 - YeastsCulture media therefor modified by introduction of foreign genetic material
• A01N 63/32 - Yeast

Abstract

Method, product and blocking element of short wavelengths in LED-type light sources consisting of a substrate with a pigment distributed on its surface and, in that said pigment has an optical density such that it allows the selective absorption of short wavelengths between 380 nm and 500 nm in a range between 1 and 99%.

IPC Classes  ?

• G01J 1/02 - Photometry, e.g. photographic exposure meter Details
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G01J 1/42 - Photometry, e.g. photographic exposure meter using electric radiation detectors
• G02B 5/22 - Absorbing filters
• G02B 19/00 - Condensers
• H04N 9/64 - Circuits for processing colour signals
• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
• A61F 2/16 - Intraocular lenses
• G01J 9/00 - Measuring optical phase differenceDetermining degree of coherenceMeasuring optical wavelength
• G02B 5/20 - Filters
• G09F 9/33 - Indicating arrangements for variable information in which the information is built-up on a support by selection or combination of individual elements in which the desired character or characters are formed by combining individual elements being semiconductor devices, e.g. diodes
• H01L 33/44 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by the coatings, e.g. passivation layer or anti-reflective coating

Abstract

The invention relates to a method for finishing artificial slopes, for controlling surface water erosion and for promoting the revegetation (or natural plant colonisation) of these surfaces, by making parallel and continuous furrows (1), oriented according to the maximum gradient of the slope. The base of the furrows (1) may have a secondary cut intended for decompacting the soil in the desired manner. The invention also relates to bucket teeth for earth and rock moving machines with which to carry out this method.

IPC Classes  ?

• E02D 17/20 - Securing of slopes or inclines
• E02F 9/28 - Small metalwork for digging elements, e.g. teeth

Abstract

The present invention discloses a device enabling the measurement of the apparent temperature felt by a subject in the face of different stimuli. Hitherto, it has only been possible to measure apparent temperature in a qualitative manner, using measurement methods that present difficulties. The present invention discloses an innovative method and device to quantify the thermal sensations of a subject, and reveals how the subject interprets the apparent temperature felt, and how he/she conceptualises the physical magnitudes related to that sensation. To this end, measurements are taken that link neuroreceptive data and statements by the subject concerning these thermal concepts, in such a way that it is possible to quantify the perception of temperature by the continuous collection of data, eliminating subjectivity and enabling the establishment of a link between different variables such as sensations, verbalisations, and quantitative and qualitative scales.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G16H 10/20 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires

Abstract

A tool and method for the decompaction of the surface of slopes. The present invention relates to a tool for preparing the soil during the completion stage of the construction of slopes and other slope maintenance operations, particularly that of aiding revegetation and reducing erosion. The tool presents a roller (1) into which diametrically symmetric rods (8) are inserted, forming pairs of spikes (2), asymmetric diametrical rods (7) or radial rods (6) that generate spikes (2) that project from the surface of the roller (1). The roller is inserted into a fork (4) by means of bearings (3) that enable it to rotate freely, with no need for mechanical traction and elements for the coupling thereof to the articulated arm of a civil works or agricultural machine. The invention likewise relates to a method for preparing or maintaining the surface of slopes that includes the use of the tool of the invention.

IPC Classes  ?

• E02D 17/20 - Securing of slopes or inclines
• A01B 45/02 - Machines for treating meadows or lawns for aerating

Abstract

22 at ambient temperature, an active layer of said sensor comprising a few-layer graphene material. The response of the sensor is not altered by relative humidity, and the sensor also demonstrates very low interference with ammonia, allowing this interference to be disregarded in the measurements.

IPC Classes  ?

• G01N 27/04 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
• C01B 32/182 - Graphene

Abstract

Structurally simple organic compounds with antitumour activity by acting on mitochondria through various action mechanisms hold substantial promise for development as cancer treatment agents. The present invention relates to new compounds with F-BODIPY structure capable of specific accumulation in mitochondria, of exhibiting photocytotoxicity without the need to involve heavy atoms or other functional residues capable of interacting in biological processes, and with the potential for developing new teragnostic agents for clinical use. Furthermore, it relates to their obtainment process and their application as fluorescent markers of mitochondria, and as photocytotoxic agents for photodynamic therapy (PDT) and phototheragnostics based on mitochondrial accumulation.

IPC Classes  ?

• C07F 5/02 - Boron compounds
• C09B 57/00 - Other synthetic dyes of known constitution
• C09K 11/07 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials having chemically-interreactive components, e.g. reactive chemiluminescent compositions

Abstract

A synthetic multi-epitope chimera as a vaccine and treatment against leishmaniasis in mammals. Synthetic chimera which includes four multi-epitope peptides against Leishmania. Each of the peptides has been selected from a Leishmania infantum protein. These are nucleosomal histones H2A, H2B, H3 and H4. The invention also relates to a pharmaceutical composition which includes the synthetic chimera. It also concerns a prophylactic and/or therapeutic vaccine against Leishmania spp. for use in mammals and especially in humans and dogs.

IPC Classes  ?

• C07K 19/00 - Hybrid peptides
• C12N 15/30 - Genes encoding protozoal proteins, e.g. from Plasmodium, Trypanosoma, Eimeria
• A61K 39/008 - Leishmania antigens
• A61P 37/02 - Immunomodulators

Abstract

in vitroin vitro in vitro wherein the new mutation has been corrected, as well as kits that include the guide pairs used in the CRISPR/Cas9 method to recover the expression of the F5 gene with said mutation.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• C12N 15/90 - Stable introduction of foreign DNA into chromosome
• C12N 5/22 - Human cells
• A61P 7/02 - Antithrombotic agentsAnticoagulantsPlatelet aggregation inhibitors
• C07K 14/745 - Blood coagulation or fibrinolysis factors

Abstract

The present invention describes a chemical composition that solves the progressive loss of antisepsis of biocidal agents for antiseptic use. This composition is a unique combination of three biocidal substances, free from any adverse or harmful effects and with legally recognised indication and action. It consists of a unique combination of three biocidal substances and water wherein one biocidal agent is an alcohol, another biocidal agent is a halogenated compound, and a third substance is an antimicrobial food additive. The immediate and sustained antiseptic effectiveness of the hydroalcoholic formulation described is far superior to other commonly used antiseptics on the market. The antiseptic may be used for domestic or sanitary purposes.

IPC Classes  ?

• A61K 8/34 - Alcohols
• A61K 8/43 - Guanidines
• A61K 8/36 - Carboxylic acidsSalts or anhydrides thereof
• A61P 31/02 - Local antiseptics
• A61Q 19/10 - Washing or bathing preparations

Abstract

A method and system for the implementation thereof is disclosed, which rapidly provides simultaneous information on the functioning of both the external and internal retina. It comprises the brief dazzling of the eye of a subject with a light source, to cause a temporary insensitivity to contrast, and to psychophysically, automatedly measure the contrast during a period of time and the moment in time when said subject detects successive visual stimuli, modulated in contrast and presented against a background of mesopic luminance. The responses provided by the subject during the recovery of the contrast sensitivity, measured by the cones of the retina, are recorded in order to obtain distinguishing parameters of this dynamics of recovery, and to compare them with a standardised database to detect disturbances in visual function typical of neurodegenerative diseases of the retina.

IPC Classes  ?

• A61B 3/06 - Subjective types, i.e. testing apparatus requiring the active assistance of the patient for testing light sensitivity, e.g. adaptationSubjective types, i.e. testing apparatus requiring the active assistance of the patient for testing colour vision
• A61B 3/02 - Subjective types, i.e. testing apparatus requiring the active assistance of the patient
• A61B 3/024 - Subjective types, i.e. testing apparatus requiring the active assistance of the patient for determining the visual field, e.g. perimeter types

Abstract

The invention relates to a refractive surface for blocking short- and medium-wavelength visible-spectrum radiation that affects human physiology. The refractive surface selectively absorbs short wavelengths between 380 nm and 500 nm, between a maximum and a minimum absorption threshold, and selectively absorbs medium wavelengths between 500 nm and 590 nm, between a maximum and a minimum absorption threshold, the selective absorption of short and medium wavelengths between 380 nm and 590 nm not completely blocking the passage of visible light in this range. Other embodiments include an LED screen, a software product and an electronic device, and ophthalmic, intraocular or sunglass lenses.

IPC Classes  ?

• G09G 3/00 - Control arrangements or circuits, of interest only in connection with visual indicators other than cathode-ray tubes
• G02B 5/22 - Absorbing filters
• A61F 9/06 - Masks, shields or hoods for welders
• G02C 7/10 - Filters, e.g. for facilitating adaptation of the eyes to the darkSunglasses

Abstract

The automatic detection of emotions via eating habits. Emotional states are related to eating patterns that affect us in our daily lives. For this reason, it is of interest to develop models that relate emotions with eating behaviour and changes therein. Most of the models require an interpretation of the emotion by the subject himself or by an observer. The present invention proposes the automatic detection of the user's emotion by using the so-called "Internet of Things". Specifically, the method is based on the use of a smart kitchen cupboard equipped with sensors and a data processing board capable of detecting the user's eating habit behaviour or changes therein, based on the food removed from the cupboard by the user.

IPC Classes  ?

• G06F 9/44 - Arrangements for executing specific programs
• G06F 7/00 - Methods or arrangements for processing data by operating upon the order or content of the data handled
• G06N 5/00 - Computing arrangements using knowledge-based models
• G05B 15/02 - Systems controlled by a computer electric

Abstract

The present invention relates to a non-human animal model of chronic glaucoma. In addition, the invention refers to a method for the preparation of said animal model, as well as to the use thereof.

IPC Classes  ?

• A01K 67/027 - New or modified breeds of vertebrates
• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61K 31/573 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
• C07K 14/78 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]

Abstract

The invention relates to germacrone derivatives that exhibit biocidal activity and can be used as antifeedants. In particular, it has been proven that these derivatives exhibit greater activity than germacrone in relation to certain types of mites and insects.

IPC Classes  ?

• A01N 35/06 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing keto or thioketo groups as part of a ring, e.g. cyclohexanone, quinoneDerivatives thereof, e.g. ketals
• A01N 31/06 - Oxygen or sulfur directly attached to a cycloaliphatic ring system

Abstract

The invention relates to the production of a icephobic surface, using the sol-gel method without fluorides, on commercial polyurethane paints and describes a new method for preparing a coating having excellent icephobic characteristics. The method is simple, easy to scale, uses low-cost raw materials and can be applied to commercial polyurethane-based paints. The method comprises preparing a sol-gel that is deposited to form a heterogeneous film of drops on a smooth and homogeneous previous layer of commercial paint. The coating allows the adhesion strength of the ice to be reduced by up to 80%. The icephobic surfaces of this invention can be used to protect surfaces in various sectors, such as aeronautics, wind, energy or telecommunications, where other anti-ice systems would not be easily applicable.

IPC Classes  ?

• C09K 3/18 - Materials not provided for elsewhere for application to surface to minimize adherence of ice, mist or water theretoThawing or antifreeze materials for application to surfaces
• C09D 183/04 - Polysiloxanes
• C09D 175/04 - Polyurethanes

Abstract

The invention relates to an endoprosthesis that is custom-designed as an implant to be anchored to a long bone of an animal, which is adaptable and customisable to the size of the medullary canal of the bone. The endoprosthesis comprises two parts that allow primary anchoring to the bone by pressure: a first part (1) made by additive manufacturing using polyether-ether-ketone (PEEK) or PEEK compounds with a hollow (12) interior; and a rod (2) made of surgical metal. The first part (1) includes an intramedullary zone (A) with mechanisms for secondary anchoring to the bone (cavities, tabs, ridges, helices) and an extramedullary zone (B) with an umbrella-shaped projection (3) having a proximal base on which rests the cortical bone into which the endoprosthesis is inserted, which also has elements for cancelling out the relative rotation of the rod on the PEEK part.

IPC Classes  ?

• A61F 2/78 - Means for protecting prostheses or for attaching them to the body, e.g. bandages, harnesses, straps, or stockings for the limb stump

Abstract

The present invention provides a new series of compounds derived from 4-hydroxyphenyl phosphonium. The invention also relates to a pharmaceutical composition comprising the compounds and to the use thereof in the treatment or prevention of diseases caused by parasites, preferably trypanosomatid parasites. In particular, these compounds have demonstrated effectiveness in vivo for the treatment of visceral leishmaniasis in a mouse model. These diseases can occur in humans and in animals.

IPC Classes  ?

• C07F 9/54 - Quaternary phosphonium compounds
• A61K 31/66 - Phosphorus compounds

Abstract

ncc ,, , ≥ 1.340; characterized in that at least one of the two longitudinal surfaces of the device comprises a photosensitizer covalently linked to said surface. This tubular medical device allows for the easy, rapid, and effective sterilization of its surface after irradiation with an external light source.

IPC Classes  ?

• A61L 2/08 - Radiation
• A61L 29/06 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• A61L 29/14 - Materials characterised by their function or physical properties
• A61L 29/16 - Biologically active materials, e.g. therapeutic substances
• A61L 31/06 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• A61L 31/14 - Materials characterised by their function or physical properties
• A61L 31/16 - Biologically active materials, e.g. therapeutic substances

Abstract

The present invention relates to a method for visually identifying the degree of suitability of a sample isolated from blood for the validation of its subsequent clinical analysis, taking into consideration the degree of hemolysis of the sample. The method includes the comparison of the plasma of the sample with a degraded, continuous scale divided into seven stages that are distributed, with an equal size, from 55° to 00° and from 00° to 351°, 00° being red in the colour wheel of the double-cone model. The invention also relates to the degraded scale and to a device containing same, which can be made of different materials (for example, paper, card, foam board, plastic or metal).

IPC Classes  ?

• A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value

Abstract

The present invention describes a tag comprising a magnetic element in the form of a microwire of 80-250 microns with giant magnetoimpedance which, when joined to an object, allows for the wireless detection of same by modulating the reflectivity of the microwire. Detection is performed by using a system that emits an electromagnetic wave that has a frequency between 1 and 20 GHz and a low frequency magnetic field (0.01-50 Hz), and detects the modulation of the reflectivity of the microwire. Thus, objects at distances greater than 1 m can be detected.

IPC Classes  ?

• G06K 19/06 - Record carriers for use with machines and with at least a part designed to carry digital markings characterised by the kind of the digital marking, e.g. shape, nature, code
• G01V 15/00 - Tags attached to, or associated with, an object, in order to enable detection of the object
• G08B 13/24 - Electrical actuation by interference with electromagnetic field distribution

Abstract

22S/Ag heterodimers with femtosecond laser pulses that lead to the formation of a protective AgCI shell. This reduces the surface traps while minimizing dot-to-medium transfer via non-radiative events. The Ag2S superdots generated as a result of this process outperform all currently available NIR-II contrast agents, enabling whole body in vivo imaging at ultra-low excitation intensities.

IPC Classes  ?

• C01G 5/00 - Compounds of silver
• B82Y 15/00 - Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• B82Y 40/00 - Manufacture or treatment of nanostructures
• C01B 17/20 - Methods for preparing sulfides or polysulfides, in general
• G01N 21/64 - FluorescencePhosphorescence
• A61K 49/00 - Preparations for testing in vivo
• C09K 11/58 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing copper, silver or gold

Abstract

The present invention in particular relates to the field of micro- and nanoparticles, more in particular to coated nanoparticles. The coatings of the present invention in particular comprise surfactant protein B (SP-B) and one or more lipids. The invention further relates to such coated particles and compositions comprising them for use as a medicament, in particular for use in the treatment of various disorders. Furthermore, the invention provides the use of the compositions of the current invention for delivering one or more agents, such as small interfacing RNA (siRNA) molecules, to the target tissue or cells.

IPC Classes  ?

• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61K 9/51 - Nanocapsules

Abstract

The present invention relates to a permanent magnet that comprises hard magnetic particles and a soft magnetic structure with an aspect ratio greater than or equal to 3 and with a single-domain magnetic structure. Furthermore, the present invention relates to the method for obtaining such a magnet and to the use of such a magnet as part of a generator or a motor vehicle. The present invention belongs to the sector of magnetic materials and their industrial applications.

IPC Classes  ?

• H01F 7/02 - Permanent magnets
• H01F 41/00 - Apparatus or processes specially adapted for manufacturing or assembling magnets, inductances or transformersApparatus or processes specially adapted for manufacturing materials characterised by their magnetic properties
• C25C 1/00 - Electrolytic production, recovery or refining of metals by electrolysis of solutions

Abstract

A relevant technological challenge is the low cost and abundant materials development for silicon surface passivation for applications in optoelectronic devices, in particular in solar cells by scalable industrial methods. In the present invention, a new hybrid material comprising PEDOT:PSS and transparent conducting oxide nanostructures is developed and a method is proposed to fabricate the composite material that passivates well the silicon surface to be used by means of a thin composite film of thickness below 200 nm.

IPC Classes  ?

• H01L 31/18 - Processes or apparatus specially adapted for the manufacture or treatment of these devices or of parts thereof
• H01L 31/04 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof adapted as photovoltaic [PV] conversion devices
• C09D 5/34 - Filling pastes
• C09D 165/00 - Coating compositions based on macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chainCoating compositions based on derivatives of such polymers
• C09D 7/61 - Additives non-macromolecular inorganic
• C09D 7/40 - Additives
• C09D 7/45 - Anti-settling agents
• C09D 5/24 - Electrically-conducting paints

Abstract

The present invention concerns aminobenzylguanidine derivative ligands specifically targeting neuroblastoma cells with an improved cellular uptake. The improved cellular uptake provides for the therapeutic and diagnostic use of the ligands in neuroblastoma-related diseases.

IPC Classes  ?

• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention provides sustained release polymeric nanocapsules capable of releasing proteases such as collagenase with a controlled kinetic and a prolonged and sustainable effect over time(up to more than 10 days). Additionally, these nanocapsules protect the housed protease, preferably collagenase,against external aggressions maintaining its catalytic activity. In this way, this invention overcomes the currents problems associated with collagenase administration using a precise combination of monomers and cross-linkers, as described in the claims that allow the formation of degradable polymeric nanocapsules with collagenase embedded within. These capsules provide a sustained release of the housed enzyme thus providing a therapeutic improvement in comparison to current therapies thus decreasing the need for repeated injections or high collagenase doses.

IPC Classes  ?

• B01J 13/14 - Polymerisation, crosslinking
• A61K 38/48 - Hydrolases (3) acting on peptide bonds (3.4)
• A61K 9/51 - Nanocapsules

Abstract

Normal writing desks used in classrooms exist in the form of a flat table with a chair connected thereto, the desk having a fixed size for a group of students of a given age but who have different heights, preventing correct posture and ergonomics, which can be harmful in the long term. The present invention proposes a writing desk that allows height, slope and lighting to be changed, adjusting to the needs of the user. In addition, the device can be produced using lightweight materials so that same can be transported, and it can also include a computer device.

IPC Classes  ?

• A47B 83/02 - Tables combined with seats
• A47B 39/02 - Adjustable forms

Abstract

The invention relates to a method for producing an encryption system having a public key and a digital signature with polynomials of few variables, based on vector exponentiation. In the field of public key cryptography, there is a growing interest in developing encryption that is secure against current attacks and also against attacks from future quantum computers. The present invention describes a novel multivariate public key cryptosystem (MPKC) that uses a novel method for building the central reversible applications, which can be used to obtain a public key with polynomials of very few variables, thereby guaranteeing high efficiency and speed in encryption, decryption and digital signature processes.

IPC Classes  ?

• H04L 9/00 - Arrangements for secret or secure communicationsNetwork security protocols

Abstract

TrypanosomatidaeTrichomonadidaeTrichomonadidae families, such as Chagas disease, leishmaniasis and trichomoniasis.

IPC Classes  ?

• C07D 231/56 - BenzopyrazolesHydrogenated benzopyrazoles
• A61K 31/416 - 1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
• A61P 33/02 - Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis

Abstract

The invention relates to a refractive surface for blocking short- and medium-wavelength visible-spectrum radiation that affects human physiology. The refractive surface selectively absorbs short wavelengths between 380 nm and 500 nm, between a maximum and a minimum absorption threshold, and selectively absorbs medium wavelengths between 500 nm and 590 nm, between a maximum and a minimum absorption threshold, the selective absorption of short and medium wavelengths between 380 nm and 590 nm not completely blocking the passage of visible light in this range. Other embodiments include an LED screen, a software product and an electronic device, and ophthalmic, intraocular or sunglass lenses.

IPC Classes  ?

• G02B 5/22 - Absorbing filters
• A61F 9/06 - Masks, shields or hoods for welders
• G02C 7/10 - Filters, e.g. for facilitating adaptation of the eyes to the darkSunglasses

Abstract

The present invention relates to new biphenylsulfoximine compounds and, in particular, to their activity as positive allosteric modulators of the dopamine D1 receptor and to their use for the treatment of pathological states for which a stimulator of this receptor activity is indicated. The invention further relates to pharmaceutical compositions containing them and to a process for the preparation of such compounds.

IPC Classes  ?

• C07C 317/14 - SulfonesSulfoxides having sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings
• A61K 31/222 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
• A61P 25/16 - Anti-Parkinson drugs

Abstract

Neospora caninum. In particular, the present invention relates to a protein composition comprising the proteins specified in Table A in an amount of at least about 2 times (fold change) higher than the same protein present in the whole tachyzoite, as calculated by quantitative label-free liquid chromatography-tandem mass spectrometry (LC-MS/MS).

IPC Classes  ?

• A61K 39/002 - Protozoa antigens
• A61K 39/012 - Coccidia antigens
• C07K 14/44 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from protozoa
• C12N 1/10 - ProtozoaCulture media therefor
• A61P 33/02 - Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

The present invention relates to a method for the diagnosis of frontotemporal dementia, a method for the diagnosis of a neurodegenerative disease, wherein the neurodegenerative disease is frontotemporal dementia or Alzheimer's disease, a method for the differential diagnosis of frontotemporal dementia and Alzheimer's, and a method for the diagnosis of Alzheimer's, said methods being based on Raman and/or infrared spectroscopy comprising recording a Raman and/or infrared spectrum of a blood sample.

IPC Classes  ?

• G01N 21/3577 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing liquids, e.g. polluted water
• G01N 21/65 - Raman scattering
• G01N 33/49 - Physical analysis of biological material of liquid biological material blood
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The invention relates to a microorganism belonging to the micro-algae species Tetraselmis mediterranea TmmRU sp. (BEA/IDA/0062), and to the use of said strain to increase the isotope ratio 235U/238U of a solution in relation to a starting solution containing residual uranium with a lower ratio 235U/238U, as well as the method for obtaining said solution which is more enriched in 235U.

IPC Classes  ?

• C12N 1/12 - Unicellular algaeCulture media therefor
• C02F 3/32 - Biological treatment of water, waste water, or sewage characterised by the animals or plants used, e.g. algae
• B01D 59/36 - Separation by biological methods
• C22B 3/18 - Extraction of metal compounds from ores or concentrates by wet processes with the aid of microorganisms or enzymes, e.g. bacteria or algae
• C22B 60/02 - Obtaining thorium, uranium or other actinides
• G21F 9/18 - Processing by biological processes
• C12R 1/89 - Algae

Goods & Services

Printed matter; Bookbinding material; Photographs; Stationery; Adhesives for stationery or household purposes; Artists' materials; Paint brushes; Office requisites; Instructional and teaching material (except apparatus); Printers' type; Paper; Paperboard; Boxes of cardboard or paper; Posters; Scrapbooks; Cards; Books; Newspapers; Prospectuses; Pamphlets; Calendars; Writing instruments; Engravings; Lithographic works of art; Paintings [pictures], framed or unframed; Patterns for dressmaking; Drawings; Paper stationery; Handkerchiefs of paper; Face towels of paper; Table linen of paper; Hygienic paper; Bags [envelopes, pouches] of paper or plastics, for packaging; Garbage bags of paper or of plastics. Clothing; Footwear; Headgear; Shirts; Leather clothing; Belts [clothing]; Furs [clothing]; Gloves [clothing]; Scarves; Neckties; Hosiery; Socks; Slippers; Beach shoes; Ski boots; Athletics shoes; Underwear. Advertising; Business management; Business administration; Office functions; Direct mail advertising; Arranging newspaper subscriptions for others; Arranging subscriptions to telecommunication services for others; Presentation of goods on communication media, for retail purposes; Business management and organization consultancy; Accounting; Document reproduction; Employment agencies; Business management for freelance service providers; Computerized file management; Web site traffic optimization; Organization of exhibitions for commercial or advertising purposes; On-line advertising on a computer network; Rental of advertising time on communication media; Publication of publicity texts; Rental of advertising space; Dissemination of advertising matter; Consultancy regarding advertising communications strategy; Public relations services; Consultancy regarding public relations communications strategy; Business auditing; Commercial intermediation services. Telecommunications; Information about telecommunication; Communications by computer terminals; Communications by fibre optic networks; Radio communications; Communications by telephone; Communications by cellular phones; Providing user access to global computer networks; Provision of on-line forums; Providing access to databases; Electronic bulletin board services [telecommunications services]; Providing telecommunications connections to a global computer network; News agencies; News agencies; Rental of telecommunication equipment; Radio broadcasting; Television broadcasting; Teleconferencing services; Videoconferencing; Electronic messaging; Rental of access time to global computer networks. Education; Providing of training; Entertainment; Sporting and cultural activities; Entertainment information; Education information; Vocational retraining; Recreation facilities (Providing -); Publication of books; Library services; Providing films, not downloadable, via video-on-demand transmission services; Production of cinematographic films; Hire of televisions; Rental of show scenery; Photography; Organisation of competitions [education or entertainment]; Arranging and conducting of colloquiums; Arranging and conducting of conferences; Arranging and conducting of congresses; Arranging of exhibitions for cultural or educational purposes; Booking of seats for shows; Game services provided on-line from a computer network; Gambling; Publication of electronic books and journals on-line. Technical assessments relating to design; Scientific research; Technical research; Design of computers for others; Development of computers; Computer software design; Software development; Research and development for others; Conducting technical project studies; Architecture; Design of interior decor; Computer software design; Installation of software; Maintenance of software; Updating of computer software; Rental of software; Computer programming; Computer system analysis; Computer system design; Consultancy in the design and development of computer hardware; Digitization of documents; Software as a service [SaaS]; Cloud computing; Information technology [IT] consultancy; Server hosting; Testing [inspection] of vehicles for roadworthiness; Graphic art design; Styling [industrial design]; Authenticating works of art; Energy auditing; Electronic data storage. Legal services; Mediation; Security services for the protection of property and individuals; Marriage agencies; Conducting religious ceremonies; Horoscope casting; Funerary undertaking; Crematorium services; Night guard services; Monitoring of burglar and security alarms; Physical security consultancy; Opening of security locks; Rental of clothing; Detective agency services; Legal research; Intellectual property consultancy; Leasing of internet domain names; On-line social networking services; Baby sitting.

Abstract

The invention relates to a material formed by a polymer substrate and a hydrogel based on vinyl-lactams and ionic methacrylates. The invention also relates to a method for producing this material and to the use thereof for cell culture and cell monolayer engineering, for preparing 3D scaffolds and manufacturing thermosensitive mechanical actuators.

IPC Classes  ?

• C08F 26/06 - Homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a heterocyclic ring containing nitrogen
• C08F 26/10 - N-Vinyl-pyrrolidone
• C08J 7/04 - Coating
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor

Abstract

The present invention relates to a method for obtaining neural stem cells and neural progenitor cells (NSC/NPC) from ovarian cortical tissue of pre-pubescent female mammals, without needing to add factors for inducing and/or expanding the neural line to the culture medium. The method of the invention can be used to obtain NSC/NPC after 8–21 days of incubation, improving the results by adding follicle stimulating hormone (FSH) to the culture medium. The NSC/NPC obtained using this method can be used in experimental models of in-vitro neurogenesis, in directed NSC/NPC differentiation to generate different types of nerve cells of interest in medicine for regenerating the nervous system, with use in autologous transplantation in cell therapy of neurodegenerative diseases, and to evaluate the neurotoxicity of different drugs, contaminants and chemical compounds.

IPC Classes  ?

• C12N 5/079 - Neural cells
• C12N 5/0797 - Stem cellsProgenitor cells
• A61K 35/12 - Materials from mammalsCompositions comprising non-specified tissues or cellsCompositions comprising non-embryonic stem cellsGenetically modified cells
• A61K 35/54 - OvariesOvaOvulesEmbryosFoetal cellsGerm cells

Abstract

The present invention in particular relates to the field of micro- and nanoparticles, more in particular to coated nanoparticles. The coatings of the present invention in particular comprise surfactant protein B (SP-B) and one or more lipids. The invention further relates to such coated particles and compositions comprising them for use as a medicament, in particular for use in the treatment of various disorders. Furthermore, the invention provides the use of the compositions of the current invention for delivering one or more agents, such as small interfering RNA (siRNA) molecules, to the target tissue or cells.

IPC Classes  ?

• A61K 9/51 - Nanocapsules
• C07K 14/785 - Alveolar surfactant peptidesPulmonary surfactant peptides

Abstract

The present disclosure relates to a memory hierarchy for a system-in-package. An example memory hierarchy is connectable to a processor via a memory management unit arranged for translating a virtual address sent by the processor into a physical address. The memory hierarchy has a data cache memory and a memory structure having at least a L1 memory array comprising at least one cluster. The memory structure comprises a first data access controller arranged for managing one or more banks of scratchpad memory of at least one of the clusters of at least the L1 memory array, comprising a data port for receiving at least one physical address and arranged for checking at run-time, for each received physical address, bits of the physical address to see if the physical address is present in the one or more banks of the at least one cluster of at least the L1 memory array.

IPC Classes  ?

• G06F 12/00 - Accessing, addressing or allocating within memory systems or architectures
• G06F 12/1045 - Address translation using associative or pseudo-associative address translation means, e.g. translation look-aside buffer [TLB] associated with a data cache
• G06F 12/0897 - Caches characterised by their organisation or structure with two or more cache hierarchy levels
• G06F 12/1009 - Address translation using page tables, e.g. page table structures
• G06F 12/0811 - Multiuser, multiprocessor or multiprocessing cache systems with multilevel cache hierarchies
• G06F 12/122 - Replacement control using replacement algorithms of the least frequently used [LFU] type, e.g. with individual count value
• G06F 12/128 - Replacement control using replacement algorithms adapted to multidimensional cache systems, e.g. set-associative, multicache, multiset or multilevel
• G06F 12/0864 - Addressing of a memory level in which the access to the desired data or data block requires associative addressing means, e.g. caches using pseudo-associative means, e.g. set-associative or hashing
• G06F 12/08 - Addressing or allocationRelocation in hierarchically structured memory systems, e.g. virtual memory systems
• G06F 12/02 - Addressing or allocationRelocation

Abstract

A relevant technological challenge is the low cost and abundant materials development for silicon surface passivation for applications in optoelectronic devices,in particular in solar cells by scalable industrial methods. In the present invention, a new hybrid material comprising PEDOT:PSS and transparent conducting oxide nanostructures is developed and a method is proposed to fabricate the composite material that passivates well the silicon surface to be used by means of a thin composite film of thickness below 200nm.

IPC Classes  ?

• H01L 51/00 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof

Abstract

The invention relates to equipment for carrying out degradation tests on components exposed to molten media at a high temperature and pressure, which guarantees the maintenance of stable testing conditions over the duration thereof, in particular in terms of the influence of the gaseous medium on the reactivity of the molten medium. The equipment includes an auxiliary system for the circulation of gases, a second auxiliary system for subjecting the agitated reactor to controlled pressure cycles, as well as being provided with an external casing for the circulation of cooling agents in order to subject the exposed materials to temperature-programmed forced cooling cycles.

IPC Classes  ?

• G01N 17/00 - Investigating resistance of materials to the weather, to corrosion or to light

Abstract

The present invention describes a label comprising a magnetic element in the form of a micro-thread of 80-250 microns with giant magnetoimpedance which, joined to an object, allows the wireless detection of same by modulating the reflectivity of the micro-thread. Detection is performed by using a system that emits an electromagnetic wave having a frequency between 1 and 20 GHz and a low-frequency magnetic field (0.01-50 Hz), and detects the modulation of the reflectivity of the micro-thread. Thus, objects at distances greater than 1 m can be detected.

IPC Classes  ?

• G06K 1/00 - Methods or arrangements for marking the record carrier in digital fashion

Abstract

The invention relates to the use of acylethanolamides in the production of a drug or nutraceutical for the prevention, relief and/or treatment of alcohol use disorders in general, and of alcohol poisoning or pathological intoxication, and alcohol dependence syndrome in particular.

IPC Classes  ?

• A61K 31/64 - Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide

Abstract

A non-invasive, ring-shaped sensor (1) for determining blood oxygen saturation and heart rate of a person performing a physical exercise comprises a signal transmitter that transmits signals through the tissue and the arterial blood volume in the finger of the person, a receiver for receiving the transmitted signals and a first communication unit (4) that sends these signals wirelessly to a second communication unit (9) of a remote electronic device (7). In the device (7) the maximum lactate concentration, in the case of the performance of a progressive and intense exercise, and the training heart rate range are determined on the basis of the oxygen desaturation value in the arterial blood volume. The invention also relates to a system that comprises a sensor (1) and a device (7), as well as to the method for determining working zones using this system.

IPC Classes  ?

• A61B 5/024 - Measuring pulse rate or heart rate
• A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters

Abstract

The present invention describes a method for determining in real time the degree of activation of the trigeminovascular system. In particular, the invention can be applied in the field of medical devices capable of determining the activation index of the trigeminovascular system, mainly on the basis of the use of biomedical signals of hemodynamic character. The method establishes objective criteria for determining the degree of activation and is described as the result of the application of modelling and data fusion techniques. The method is also based on another type of signals, such as ambient signals, in order to improve statistically in real time the degree of activation determined.

IPC Classes  ?

• G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)
• G08B 21/02 - Alarms for ensuring the safety of persons

Abstract

The invention relates to a method and electronic device for: detecting the light emission level that a light source emits to the ocular system of a user; measuring the user’s level of aversion to the quantity of light received in his/her ocular system, by analysing his/her ocular reaction; and comparing the level of aversion to the quantity of light received by the user’s ocular system, measured in step (b), with the level of aversion that is acceptable to said user and stored in a memory (102) of an electronic device (100).

IPC Classes  ?

• A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
• G01J 1/44 - Electric circuits
• G01J 1/18 - Photometry, e.g. photographic exposure meter by comparison with reference light or electric value using electric radiation detectors using comparison with a reference electric value

Abstract

The invention relates to a micro-composite material based on permanent magnets formed from magnetically hard ceramic particles of hexagonal ferrite and magnetically soft particles of metal alloys, and to the method for producing same by means of mechanical alloying in the presence of a coupling agent. Nanoparticle-based permanent magnets without rare earth elements have a complex and costly industrial production method. The invention describes the production of a composite material based on micro-scale (non-nano-scale) ferrite and metallic alloys, by means of mechanical grinding methods. A product is obtained using a low-cost, industrialisable, easily scalable production method, with which composite materials with favourable micro-structural and magnetic properties are obtained, said materials being characterised in that they have an increase in maximum energy product (BHmax) of up to 30% with respect to the main component of ferrite.

IPC Classes  ?

• H01F 7/02 - Permanent magnets
• H01F 41/00 - Apparatus or processes specially adapted for manufacturing or assembling magnets, inductances or transformersApparatus or processes specially adapted for manufacturing materials characterised by their magnetic properties

Abstract

The present invention relates to new protein compositions, methods for producing said protein compositions, pharmaceutical compositions comprising said protein compositions and methods for treating infections caused by Neospora caninum. In particular, the present invention relates to a protein composition comprising the proteins specified in Table A in an amount of at least about 2 times (fold change) higher than the same protein present in the whole tachyzoite, as calculated by quantitative label-free liquid chromatography-tandem mass spectrometry (LC-MS/MS).

IPC Classes  ?

• A61K 39/002 - Protozoa antigens
• C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• C07K 14/44 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from protozoa

Abstract

The present invention relates to new protein compositions, methods for producing said protein compositions, pharmaceutical compositions comprising said protein compositions and methods for treating infections caused by Neospora caninum. In particular, the present invention relates to a protein composition comprising the proteins specified in Table A in an amount of at least about 2 times (fold change) higher than the same protein present in the whole tachyzoite, as calculated by quantitative label-free liquid chromatography-tandem mass spectrometry (LC-MS/MS).

IPC Classes  ?

• A61K 39/002 - Protozoa antigens
• C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• C07K 14/44 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from protozoa

Abstract

The invention relates to two families of 5-nitroindazole derivatives that have antiparasitic properties and to the use thereof for the production of a drug, preferably for the treatment of infections caused by pathogenic protozoa from the Trypanosomatidae and Trichomonadidae families, such as Chagas disease, leishmaniasis and trichomoniasis.

IPC Classes  ?

• C07D 231/56 - BenzopyrazolesHydrogenated benzopyrazoles
• A61K 31/416 - 1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole

Abstract

The invention relates to a method for producing a cementitious composite, comprising: 1) a first step of conditioning silica nanoparticles, in which the nanoparticles are heated to a temperature of between 85-235°C for a sufficiently long time interval so as to obtain a maximum moisture content of 0,3% relative to the total weight of the material resulting from the first step; 2) a dry dispersion step, in which the nanoparticles conditioned in step 1) are dispersed over cement and in which inert grinding balls are used; 3) a step of conditioning the cementitious composite obtained in step 2), in which the grinding balls are separated from the cementitious composite produced. The invention also relates to the resulting composite, to cement derivatives comprising said composite, preferably mortars and concrete, to the production method thereof and to the use of these materials in industry.

IPC Classes  ?

• C04B 14/04 - Silica-rich materialsSilicates
• C04B 28/00 - Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements

Abstract

The present invention relates to a sensor that is able to perform joint measurements of electrochemical impedance and noise and of resistance to polarisation, enabling continuous, reliable control of general and localised corrosion processes. This monitoring system is suitable for low- and high-temperature industrial or process atmospheres in which a melted, gas or liquid phase is present, be it, for example, from metals, alloys, salts or glass, all in melted state.

IPC Classes  ?

• G01N 17/02 - Electrochemical measuring systems for weathering, corrosion or corrosion-protection measurement
• G01N 27/02 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance

Abstract

The invention relates to diruthenium compounds with an open-paddlewheel structure, to the stabilisation thereof, to the production method thereof, and to methods for using said compounds in the analysis of the secondary and tertiary structure of RNA, particularly in the determination of intersections between helices or the transition between helices and loops. The invention also relates to a kit containing diruthenium compounds with an open-paddlewheel structure and to the appropriate means for using same in the analysis of the structure of RNA.

IPC Classes  ?

• C07F 15/00 - Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
• G01N 33/48 - Biological material, e.g. blood, urineHaemocytometers

Abstract

The invention relates to a refractive surface for blocking short- and medium- wavelength visible-spectrum radiation that affects human physiology. The refractive surface selectively absorbs short wavelengths between 380 nm and 500 nm, between a maximum and a minimum absorption threshold, and selectively absorbs medium wavelengths between 500 nm and 590 nm, between between a maximum and a minimum absorption threshold, the selective absorption of short and medium wavelengths between 380 nm and 590 nm not completely blocking the passage of visible light in this range. Other embodiments include an LED screen, a software product and an electronic device, and ophthalmic, intraocular or sunglass lenses.

IPC Classes  ?

• A61F 9/00 - Methods or devices for treatment of the eyesDevices for putting in contact-lensesDevices to correct squintingApparatus to guide the blindProtective devices for the eyes, carried on the body or in the hand

Abstract

The present invention relates to an in vitro method for the prognosis or prediction of the response to treatment with anti-psychotic drugs in subjects who have suffered first episode psychosis (FEP), and specifically to the use of the expression value, in a biological sample isolated from said subjects, of the ratio formed by two of the isoforms – active isoform and truncated isoform – of the receptor (TrKB) of the nerve growth factor BDNF, named TrKB-FL and TrkB-T, respectively. The present invention also describes kits and uses of same to implement the method of the invention.

IPC Classes  ?

• G01N 33/536 - ImmunoassayBiospecific binding assayMaterials therefor with immune complex formed in liquid phase
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The invention relates to bioactive hydrogels produced with natural-origin ingredients, which are cross-linked via electrostatic-type interactions and which include bone morphogenetic proteins (BMP), and to the method for producing said hydrogels. The invention also relates to the application of these bioactive hydrogels for producing sanitary products, pharmaceutical compositions and/or polymeric implants for bone and cartilage regeneration.

IPC Classes  ?

• A61L 27/52 - Hydrogels or hydrocolloids

Abstract

The invention relates to an optoelectronic device for determining the degree of collimation of a light beam, which can also be used for collimating beams by means of the incorporation of a collimation element (2). The device comprises a diffraction grating (3), a mask (5) including a plurality of windows (4) each having a diffraction grating, said diffraction gratings of the windows (4) being out of phase with one another, a matrix (7) of photodetectors (8), the number of which can be greater than or equal to the number of windows (4) of the mask (5) or which can be located in a matrix with two-dimensional distribution (CMOS or CCD), and one or more data processing elements (8). The invention also relates to methods for determining the degree of collimation of a light beam or for collimating a beam.

IPC Classes  ?

• G02B 27/30 - Collimators
• G01B 11/00 - Measuring arrangements characterised by the use of optical techniques
• G02B 23/10 - Telescopes, e.g. binocularsPeriscopesInstruments for viewing the inside of hollow bodiesViewfindersOptical aiming or sighting devices involving prisms or mirrors reflecting into the field of view additional indications, e.g. from collimator
• G01T 1/29 - Measurement performed on radiation beams, e.g. position or section of the beamMeasurement of spatial distribution of radiation

Abstract

The invention relates to an apparatus for carrying out degradation tests on materials exposed to melted means, which ensures continuous stable test conditions throughout the duration of the testing, in a specific manner, in terms of the influence of the gaseous medium on the reactivity of the melted medium. To this end, the apparatus has an auxiliary gas circulation system that can capture the gaseous effluents generated, condense and purge the unwanted fractions and recirculate them into the test chamber. The apparatus allows closed-loop operation with different melted media and in-line corrosion monitoring sensors can be inserted.

IPC Classes  ?

• G01N 17/00 - Investigating resistance of materials to the weather, to corrosion or to light

Abstract

The invention relates to a method for sterilising materials that have been biologically contaminated, using CO2 and water. More concretely, the invention has been devised for cases where the materials being sterilised are sensitive materials, such as electronic and optical materials and technical apparel. The invention also relates to the apparatus developed for implementing the sterilisation method according to the invention. The conditions under which the treatment is performed preserve the properties of the sterilised materials and therefore allow said materials to be reused.

IPC Classes  ?

• A01N 59/04 - Carbon disulfideCarbon monoxideCarbon dioxide

Abstract

The invention relates to a gene construct for amplifying the response to signals that activate the cell integrity pathway (CWI) in Saccharomyces cerevisiae. It comprises a hyperactive allele of the MAPKK of this pathway, under the control of the promoter of a gene inducible by Rlm1, which involves the creation of a positive feedback loop, the stimulation of which leads to cell death. The invention also relates to the methods for detecting agents that alter the cell wall or the function of components of the pathway itself, which allows the detection of pharmacological antifungal and/or antitumour compounds.

IPC Classes  ?

• C12N 15/80 - Vectors or expression systems specially adapted for eukaryotic hosts for fungi
• C12Q 1/25 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving enzymes not classifiable in groups

Abstract

The invention relates to nanocrystalline titanium dioxide with mixing of anatase and rutile phases in proportion and/or spatial distribution controlled by means of laser irradiation. Titanium dioxide is a material with a wide range of applications for which a certain polymorphism is required, owing to which it is necessary to find methods for controlling the anatase-rutile phase transition, which allow the mixing of the two phases to be regulated. The invention also relates to the production of nanocrystalline titanium oxide with mixing of anatase and rutile phases controlled quantitatively and/or spatially with micrometric resolution by means of laser stamping. This phase control allows multifunctional and polyvalent devices to be designed on the basis of nanocrystalline titanium oxide and the different properties of the anatase and rutile phases thereof.

IPC Classes  ?

• G01N 21/65 - Raman scattering
• C09C 1/36 - Compounds of titanium
• C01G 23/08 - DryingCalcining

Abstract

Some applications of titanium oxide in the anatase phase are limited when they transition into the rutile phase when the temperature is increased, rendering of interest the existence of methods for controlling the anatase-rutile transition, which allow the mixing of the phases to be controlled and increase the range of working temperatures of the pure anatase in the form of nanoparticles. The present invention relates to the production of titanium dioxide with controlled mixing of the anatase-rutile phases based on doping with Al and Fe without incorporating other additives. The titanium oxide produced in this way can be applied to developments for catalysis, functional coatings, materials for energy, optoelectronic devices and different types of sensors.

IPC Classes  ?

• C01G 23/047 - Titanium dioxide
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites

Abstract

The present invention shows extremely small iron oxide nanoparticles, 2 nm core size, 68Ga core-doped through a microwave driven synthesis that provides an expedited protocol with radiolabelling efficiency yield of around 90%, optimal for short half-lived isotopes. In vivo hot spot MRI (T1 weighted contrast) and PET imaging are demonstrated with unprecedented quality for iron oxide-based dual modality probes. The results incorporated herein show, for the first time, a new concept for dual-modality nanoparticle production and effective probe production with single core integration of both sources of contrast that will sury boost a large number of cardiovascular applications.

IPC Classes  ?

• H01F 1/00 - Magnets or magnetic bodies characterised by the magnetic materials thereforSelection of materials for their magnetic properties
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• A61K 49/00 - Preparations for testing in vivo
• A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
• A61K 49/18 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
• B82B 3/00 - Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units

Abstract

Wireless sensor for detecting pressure. The invention relates to a wireless pressure-detecting sensor comprising a closed ring of amorphous magnetoelastic microwire. The invention also relates to a device for detecting the pressure exerted by a fluid flowing through a conduit or tube that has rigid or flexible walls and comprises said sensor, and to a method used to detect the pressure in the conduit or tube.

IPC Classes  ?

• G05D 16/08 - Control of liquid pressure
• C22C 45/04 - Amorphous alloys with nickel or cobalt as the major constituent
• A61B 5/021 - Measuring pressure in heart or blood vessels
• A61B 5/03 - Measuring fluid pressure within the body other than blood pressure, e.g. cerebral pressure
• A61F 2/06 - Blood vessels

Abstract

The invention relates to a calibration method for magnetic probes for magnetic needle interfacial shear rheometers, comprising: taking measurements (202) of the movement of the magnetic probe (14) in a film-free water-air interface within a range of frequencies ω; obtaining (204) the deformation/force amplitude ratio AR(ω) and the phase difference δ(ω) between the voltage σ applied to the coils (3) of the rheometer (9) and the surface deformation γ produced by the movement (d) of the magnetic probe (14); setting initial values for the unit conversion constant C and the effective elastic constant of the oscillator k; obtaining the speed profile in the sub-phase (206) by numerically solving the speed field equations; obtaining (210) a distance D(Cj, kj) between the theoretical deformation/force amplitude ratio ART ratio and the experimental deformation/force amplitude ratio ARE for different values of C and k; selecting (212) the pair (Cmin, kmin) that minimises the distance D(Cj, kj).

IPC Classes  ?

• G01N 11/16 - Investigating flow properties of materials, e.g. viscosity or plasticityAnalysing materials by determining flow properties by moving a body within the material by measuring damping effect upon oscillatory body

Abstract

The invention relates to a roll-on device which can be used to dispense exact doses of liquid and/or semi-solid formulations onto a surface, from a multi-dose container. The invention includes a non-return valve (4) that allows a volumetric space (2) to be filled, while preventing the dose, or part of the dose, from returning into the multi-dose container. The volumetric space (2) is defined by a sphere (1) contained inside a cylinder (3) and by a base (11), and houses an exact dose of the substance of interest. In addition, the invention relates to a filler material contained in the volumetric space (2) inside the roll-on device in order to allow the application of both liquid and semi-solid formulations in exact doses and in a constant manner.

IPC Classes  ?

• B05C 1/00 - Apparatus in which liquid or other fluent material is applied to the surface of the work by contact with a member carrying the liquid or other fluent material, e.g. a porous member loaded with a liquid to be applied as a coating
• A45D 34/00 - Containers or accessories specially adapted for handling liquid toiletry or cosmetic substances, e.g. perfumes

Abstract

The invention relates to an established cell line of canine inflammatory mammary carcinoma, of triple-negative basal epithelial cells. The invention also relates to a method for achieving stable xenotransplants of canine inflammatory mammary carcinoma in animals for testing, and to the use of the cell line and xenotransplants in the study of both canine inflammatory mammary carcinoma and human inflammatory breast carcinoma and to the use thereof for the in vitro identification of therapeutically useful compounds for the treatment of human inflammatory breast cancer. The invention further relates to a kit for the in vitro study of canine IMC and/or human IBC, of pharmaceuticals that are potentially useful against human IBC, including the cell line of the invention.

IPC Classes  ?

• C12N 5/09 - Tumour cells

Abstract

The concentration of butanol in fermentation broths is low and, consequently, butanol recovery with traditional techniques requires a large amount of energy. The invention relates to a low-energy-consumption method for the recovery of butanol. The method consists of an adsorption/desorption process using a polymer resin as an adsorbent. The desorption step is performed more efficiently and combined with condensation and decantation steps.

IPC Classes  ?

• C07C 29/74 - SeparationPurificationStabilisationUse of additives
• B01D 15/00 - Separating processes involving the treatment of liquids with solid sorbentsApparatus therefor
• C12F 3/00 - Recovery of by-products

Abstract

Method, device (100) and system (200) for detection and quantification of the variation of eye damage caused by the blue and violet light of the visible spectrum comprising the steps of detecting the incident radiation on an individual's visual system; calculating the incident radiation within the range between 380 and 500 nm; establishing at least one threshold of incident radiation within said range; detecting if at least one threshold established for said range has been exceeded; warning of the excess of at least one threshold; measuring the exposure time to incident radiation; and inferring in the different ocular structures of an individual the effect of incident radiation and warning of such effect.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G02B 5/22 - Absorbing filters
• A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
• H04N 9/64 - Circuits for processing colour signals
• G02B 19/00 - Condensers
• G01J 1/02 - Photometry, e.g. photographic exposure meter Details
• G01J 1/42 - Photometry, e.g. photographic exposure meter using electric radiation detectors
• A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• A61B 5/024 - Measuring pulse rate or heart rate
• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
• H01L 33/44 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by the coatings, e.g. passivation layer or anti-reflective coating
• G02B 5/20 - Filters

Abstract

The invention relates to a novel implant based on titanium, consisting of a titanium coating formed over biomaterials, applicable in bone implantology. The nanotopographical characteristics of said implants inhibit bacterial adhesion and formation of bacterial biofilm on the surface, the implants simultaneously exhibiting suitable properties for the adhesion, extension, and proliferation of the bone-forming cells. The invention also relates to a method for producing the implant by means of oblique incidence techniques and to the use thereof in bone implantology.

IPC Classes  ?

• A61C 13/00 - Dental prosthesesMaking same
• A61L 27/06 - Titanium or titanium alloys
• A61L 27/30 - Inorganic materials
• A61F 2/28 - Bones
• C23C 14/16 - Metallic material, boron or silicon on metallic substrates or on substrates of boron or silicon
• C23C 14/35 - Sputtering by application of a magnetic field, e.g. magnetron sputtering

Abstract

The invention relates to a compound material comprising inorganic salts of nitrate and chloride anions, which can also comprise sulfates, carbonates and/or nitrites and inorganic and organic nanoparticles, such as graphene, and cations of the chemical groups of the alkali metals, alkaline-earth metals, icosagens, crystallogens and/or chalcogens. Said formulations have physical and chemical characteristics, such as the heat capacity, heat stability and heat conductivity thereof, which render them optimum for using as alternatives to the commercial binary mixture in solar concentration plants.

IPC Classes  ?

• C09K 5/00 - Heat-transfer, heat-exchange or heat-storage materials, e.g. refrigerantsMaterials for the production of heat or cold by chemical reactions other than by combustion
• C09K 5/12 - Molten materials, i.e. materials solid at room temperature, e.g. metals or salts

Abstract

Method, product and blocking element of short wavelengths in LED-type light sources consisting of a substrate with a pigment distributed on its surface and, in that said pigment has an optical density such that it allows the selective absorption of short wavelengths between 380 nm and 500 nm in a range between 1 and 99 %.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G01J 1/02 - Photometry, e.g. photographic exposure meter Details
• G01J 1/42 - Photometry, e.g. photographic exposure meter using electric radiation detectors
• G02B 19/00 - Condensers
• H04N 9/64 - Circuits for processing colour signals
• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
• G02B 5/20 - Filters
• G02B 5/22 - Absorbing filters
• H01L 33/44 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by the coatings, e.g. passivation layer or anti-reflective coating