Abrégé

In cases of acute and chronic kidney damage, BET (Bromodomain and Extra-Terminal domain) inhibitors, such as the JQ1 molecule, can be used to inhibit the UPR (Unfolded Protein Response) pathway and other inflammatory and pro-fibrotic pathways, thus improving tissue damage and restoring kidney function. Nevertheless, JQ1 exhibits toxicity and low specificity, so that in order to achieve a suitable therapeutic effect, high doses that are incompatible with a low degree of toxicity must be used. The present invention proposes a solution to the poor pharmacokinetic profile of JQ1 and its low oral availability that comprises designing and developing lipid-based nanoparticles that make it possible to encapsulate and selectively administer the JQ1 inhibitor in sufficient quantity to achieve the desired therapeutic effect and at the same time reduce its toxicity.

Classes IPC  ?

• A61K 9/127 - Liposomes
• A61P 13/12 - Médicaments pour le traitement des troubles du système urinaire des reins

Abrégé

The present invention relates to the chemical synthesis and production of compounds derived from imidazo[1,2-a]pyridine of formula I, wherein R2, R3, R5, R6and R7 have the meanings indicated in the description; a method for obtaining same; and the therapeutic use thereof as a pharmaceutical composition for anti-inflammatory use in vitro and in vivo in diseases involving inflammatory and pro-fibrotic processes.

Classes IPC  ?

• C07D 471/04 - Systèmes condensés en ortho
• A61K 31/437 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à cinq chaînons ayant l'azote comme hétéro-atome du cycle, p.ex. indolizine, bêta-carboline
• A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p.ex. agents antirhumatismaux; Médicaments anti-inflammatoires non stéroïdiens [AINS]

Abrégé

Method, product and blocking element of short wavelengths in LED-type light sources consisting of a substrate with a pigment distributed on its surface and, in that said pigment has an optical density such that it allows the selective absorption of short wavelengths between 380 nm and 500 nm in a range between 1 and 99%.

Classes IPC  ?

• G02B 5/22 - Filtres absorbants
• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
• A61B 5/11 - Mesure du mouvement du corps entier ou de parties de celui-ci, p.ex. tremblement de la tête ou des mains ou mobilité d'un membre
• A61F 2/16 - Lentilles intraoculaires
• G01J 1/02 - Photométrie, p.ex. posemètres photographiques - Parties constitutives
• G01J 1/42 - Photométrie, p.ex. posemètres photographiques en utilisant des détecteurs électriques de radiations
• G01J 9/00 - Mesure du déphasage des rayons lumineux; Recherche du degré de cohérence; Mesure de la longueur d'onde des rayons lumineux
• G02B 5/20 - Filtres
• G02B 19/00 - Condenseurs
• G09F 9/33 - Dispositifs d'affichage d'information variable, dans lesquels l'information est formée sur un support, par sélection ou combinaison d'éléments individuels dans lesquels le ou les caractères désirés sont formés par une combinaison d'éléments individuels à semi-conducteurs, p.ex. à diodes
• H01L 33/44 - DISPOSITIFS À SEMI-CONDUCTEURS NON COUVERTS PAR LA CLASSE - Détails caractérisés par les revêtements, p.ex. couche de passivation ou revêtement antireflet
• H04N 9/64 - Circuits pour le traitement de signaux de couleur

Abrégé

The invention relates to an optoelectronic device for simultaneously determining the absolute retardance and the rotation angle of the fast eigenstate of an optical retarder (4). The device comprises a light source (1), a polarisation control system (2), an interferometer (3) capable of producing two different polarisation states, a system for rotating the optical retarder (4) to be characterised, a second polarisation control system (5), a photodetection system (6) and a data processing system (7). The invention also relates to methods for simultaneously calculating the absolute retardance and the rotation angle of the fast axis of an optical retarder (4) from measurements of the rotation angle of the retarder (4) and measurements from the photodetection system (6).

Classes IPC  ?

• G01B 9/02 - Interféromètres

Abrégé

The present disclosure relates to the compounds of formula (I) or their pharmaceutically acceptable salts, or their stereoisomers or mixtures of stereoisomers, either of the compound of formula (I) or of any of its pharmaceutically acceptable salts which are NPM1 inhibitors. It also relates to pharmaceutical compositions containing them, and to their use in medicine, in particular in the treatment and/or prevention of cancer.

Classes IPC  ?

• C07D 209/90 - Benzo [c, d] indoles; Benzo [c, d] indoles hydrogénés
• A61K 31/403 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p.ex. sulpiride, succinimide, tolmétine, buflomédil condensés avec des carbocycles, p.ex. carbazole
• A61P 35/02 - Agents anticancéreux spécifiques pour le traitement de la leucémie

Abrégé

The invention relates to a pharmaceutical combination comprising bevacizumab (BVZ) and delta-9-tetrahydrocannabinol (THC) for use in the treatment of glioma, in particular glioblastoma, and a combination comprising bevacizumab (BVZ), temozolomide (TMZ) and the mixture of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in the ratio of 1:1 for use in the treatment of glioma, in particular glioblastoma.

Classes IPC  ?

• A61K 39/395 - Anticorps; Immunoglobulines; Immunsérum, p.ex. sérum antilymphocitaire
• A61K 31/53 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec trois azote comme seuls hétéro-atomes d'un cycle, p.ex. chlorazanil, mélamine
• A61K 31/352 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p.ex. fungichromine ayant des cycles à six chaînons avec un oxygène comme seul hétéro-atome d'un cycle condensés avec des carbocycles, p.ex. cannabinols, méthanthéline
• A61P 35/00 - Agents anticancéreux

Abrégé

The present invention relates to a coagulation factor V-deficient non-human animal model that includes an amino acid replacement in the FV protein that reproduces the human mutation Thr1898Met. In particular, the present invention relates to a mouse animal model, with the mutation located in Thr1857Met of the murine FV protein. The invention includes heterozygous and homozygous mutants for this mutation, producing viable litters and subjects with mild clinical signs of the disease which do not cause the animal to suffer. The present invention further relates, on the one hand, to a method for producing non-human coagulation factor V-deficient animals using gene editing and assisted reproduction techniques using zygote microinjection and, on the other hand, to the use of the animal model in the study of drugs for the treatment of coagulation factor V deficiency.

Classes IPC  ?

• C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales
• C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteurs; Vecteurs; Utilisation d'hôtes pour ceux-ci; Régulation de l'expression

Abrégé

The invention relates to a method for obtaining coacervates comprising a polymer and spores of at least one fungus used for the biocontrol of agricultural pests, for use thereof as a tool in the biocontrol of plant diseases and pests, the method comprising the steps of dissolving a polymer in a weak acid buffer, adding spores of at least one fungus used as a biocontrol agent, agitating to obtain a homogenous dispersion, and adding an aqueous solution at a basic pH to the previous solution.

Classes IPC  ?

• A01N 25/28 - Microcapsules
• A01N 63/30 - Champignons microscopiques; Substances produites par des champignons microscopiques ou obtenues à partir de ceux-ci
• C12N 11/10 - Enzymes ou cellules microbiennes immobilisées sur ou dans un support organique le support étant un hydrate de carbone
• C12N 1/04 - Conservation des micro-organismes à l'état viable
• A01P 5/00 - Nématicides
• C12R 1/165 - Corynebacterium poinsettiae

Abrégé

The present invention relates to an in vitro diagnostic method to differentiate African Swine Fever Virus (ASFV) infected animals from animals which have been vaccinated against ASFV using an immunogenic composition comprising an attenuated ASFV in which the EP153R gene and the EP402R gene have been inactivated and wherein the region of the ASFV genome comprising the EP402R and the EP153R genes is replaced by a heterologous gene.

Classes IPC  ?

• G01N 33/569 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour micro-organismes, p.ex. protozoaires, bactéries, virus

Abrégé

The present invention relates to African Swine Fever (ASF) attenuated viruses wherein the genes EP402R and EP153R have been inactivated, which can be used as a vaccine. The attenuated viruses protect pigs against subsequent challenge with virulent virus. The present invention also relates to the use of such attenuated viruses to treat and/or prevent ASF.

Classes IPC  ?

• A61K 39/12 - Antigènes viraux
• A61P 31/20 - Antiviraux pour le traitement des virus ADN
• C12N 7/04 - Inactivation ou atténuation; Production de parties élémentaires de virus

Abrégé

A chemiresistive sensor has a low limit for detecting NO2 at ambient temperature. An active layer of the sensor includes a few-layer graphene material. The response of the sensor is not altered by relative humidity, and the sensor also demonstrates very low interference with ammonia, allowing this interference to be disregarded in the measurements.

Classes IPC  ?

• G01N 27/12 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance en recherchant la résistance d'un corps solide dépendant de la réaction avec un fluide
• G01N 33/00 - Recherche ou analyse des matériaux par des méthodes spécifiques non couvertes par les groupes

Abrégé

The present invention relates to a non-human animal model of chronic glaucoma. In addition, the invention refers to a method for the preparation of said animal model, as well as to the use thereof.

Classes IPC  ?

• A01K 67/027 - Nouvelles races de vertébrés
• A61K 9/16 - Agglomérés; Granulés; Microbilles
• A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrène; Leurs dérivés, p.ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p.ex. prégnane ou progestérone substitués en position 21, p.ex. cortisone, dexaméthasone, prednisone ou aldostérone
• A61K 38/39 - Peptides du tissu connectif, p.ex. collagène, élastine, laminine, fibronectine, vitronectine, globuline insoluble à froid [CIG]

Abrégé

The present invention refers to a peptide, comprising or consisting of SEQ ID NO: 1 (CAYMTMKIRN), for use as a medicament, preferably in the prevention and/or treatment of cardiac damage arising after ischemia followed by reperfusion, or in the prevention and/or treatment of the inflammatory response following acute myocardial infarction. In a preferred embodiment, the peptide is conjugated with a nanoparticle.

Classes IPC  ?

• A61K 47/62 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant une protéine, un peptide ou un acide polyaminé
• A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p.ex. émulsion, particule, complexe d’inclusion, stent ou kit
• A61P 9/00 - Médicaments pour le traitement des troubles du système cardiovasculaire

Abrégé

The invention relates to a method for enhancing the osteogenic differentiation of mesenchymal stromal cells (MSCs) by culturing same in an osteogenic medium with an added EphB3-receptor blocking reagent. The blocking reagent may be selected from polyclonal antibodies, monoclonal antibodies, fusion proteins or a combination thereof. The invention also relates to the cells of the osteogenic lineage obtained using the described method and to the EphB3-receptor blocking reagents, for use in the treatment of bone diseases causing bony tissue deficiency and/or bone fractures. The invention also relates to pharmaceutical compositions containing the cells of the osteogenic lineage obtained using the method and/or the EphB3-receptor blocking reagents.

Classes IPC  ?

• C12N 5/077 - Cellules mésenchymateuses, p.ex. cellules osseuses, cellules de cartilage, cellules stromales médulaires, cellules adipeuses ou cellules musculaires
• A61K 35/28 - Moelle osseuse; Cellules souches hématopoïétiques; Cellules souches mésenchymateuses de toutes origines, p.ex. cellules souches dérivées de tissu adipeux

Abrégé

The present invention relates to novel water-soluble BODIPY dyes by means of simple boron functionalisation. The known hydrophobicity of BODIPYs and most common analogues thereof represents an important limitation to its optimal use in some applications that require water solubility, meaning that it is of interest to obtain BODIPYs that are soluble in water or in highly hydrophilic media from conventional precursor BODIPYs. The invention relates to the structural design, synthetic access and water solubility of a novel group of hydrophilic molecular dyes belonging to the BODIPY family, which are advantageous due to the generality and ease of obtainment thereof from conventional BODIPY dyes (F-BODIPY-based), said production entailing the minimal disturbance of the photophysical properties of the starting dye, as well as a significant chemical and photophysical robustness, which implies the potential use thereof in photonic, physical and chemical applications in aqueous or highly hydrophilic media.

Classes IPC  ?

• C07F 5/02 - Composés du bore
• C09B 57/00 - Autres colorants synthétiques de structure connue
• C09K 11/07 - Substances luminescentes, p.ex. électroluminescentes, chimiluminescentes contenant des substances organiques luminescentes ayant des constituants réagissant chimiquement entre eux, p.ex. compositions chimi-luminescentes réactives
• G03C 1/735 - Composés organo-métalliques

Abrégé

Current treatments for surgical site infections that are caused by fungi or bacteria with antibiotics and antifungal agents are usually based on the prolonged intravenous administration or use of polymethyl methacrylate cements after removing the prosthesis and cleaning the surrounding tissue, which requires another surgical procedure. However, an administration system that avoids high body exposure to the antimicrobial agent and prevents the patient from having to undergo a new surgery would be more desirable. The present invention discloses 3D printed implants with biocompatible and biodegradable polymers comprising medicinal drugs with immediate-sustained release, having a reduced haemolytic profile, which easily adhere to the prostheses, exhibit a good in vitro efficacy profile against different fungal and bacterial strains and can be sterilised by means of UV light due to the thinness thereof.

Classes IPC  ?

• A61B 17/56 - Instruments ou procédés chirurgicaux pour le traitement des os ou des articulations; Dispositifs spécialement adaptés à cet effet

Abrégé

The present invention relates to compounds of formula (I), in addition to the use thereof for the treatment and/or prevention of diseases caused by protozoa, especially those belonging to the genus Leishmania or Trypanosoma. The present invention likewise relates to pharmaceutical compositions comprising said compounds. (I)

Classes IPC  ?

• A61K 31/4184 - 1,3-Diazoles condensés avec des carbocycles, p.ex. benzimidazoles
• A61K 31/4402 - Pyridines non condensées; Leurs dérivés hydrogénés substituées uniquement en position 2, p.ex. phéniramine, bisacodyl
• A61K 31/444 - Pyridines non condensées; Leurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p.ex. amrinone
• C07D 235/14 - Radicaux substitués par des atomes d'azote
• C07D 213/06 - Composés hétérocycliques contenant des cycles à six chaînons, non condensés avec d'autres cycles, ne comportant qu'un atome d'azote comme unique hétéro-atome du cycle et avec au moins trois doubles liaisons entre chaînons cycliques ou entre chaînons comportant trois liaisons doubles ne comportant pas de liaison entre l'atome d'azote du cycle et un chaînon non cyclique ou ne comportant que des atomes d'hydrogène ou de carbone liés directement à l'atome d'azote du cycle contenant uniquement des atomes d'hydrogène et de carbone en plus de l'atome d'azote du cycle

Abrégé

Controlling blood glucose is a difficult task that diabetic people usually need to carry out on their own. An accurate and timely prediction is vital to make decisions and recommend corrective actions. For this reason, there is a need to develop methods for efficiently and accurately predicting the glucose value that enables blood glucose control systems to be implemented safely using simple devices that are comfortable for the patient. The present invention discloses a non-invasive method and system for predicting glucose values, based on the estimation from a number of variables measured with an activity wristband. The system uses variables that are not directly related with glucose to estimate and predict glucose values and it generates warnings in dangerous cases of hypoglycaemia and hyperglycaemia.

Classes IPC  ?

• G16H 50/00 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies
• A61B 5/15 - Dispositifs de prélèvement d'échantillons de sang
• G16H 50/50 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour la simulation ou la modélisation des troubles médicaux

Abrégé

The present disclosure relates to the compounds of formula (I) or their pharmaceutically acceptable salts, or their stereoisomers or mixtures of stereoisomers, either of the compound of formula (I) or of any of its pharmaceutically acceptable salts which are NPM1 inhibitors. It also relates to pharmaceutical compositions containing them, and to their use in medicine, in particular in the treatment and/or prevention of cancer.

Classes IPC  ?

• C07D 209/88 - Carbazoles; Carbazoles hydrogénés avec des hétéro-atomes ou des atomes de carbone comportant trois liaisons à des hétéro-atomes avec au plus une liaison à un halogène, p.ex. radicaux ester ou nitrile, liés directement aux atomes de carbone du système cyclique
• C07D 401/04 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
• C07D 403/04 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
• C07D 409/04 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
• A61K 31/40 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p.ex. sulpiride, succinimide, tolmétine, buflomédil
• A61P 35/02 - Agents anticancéreux spécifiques pour le traitement de la leucémie

Abrégé

The present invention relates to a sensor device that comprises a sensor chip for sensing magnetic fields which has a sensor cell and further comprises a casing made of an encapsulation material, wherein the sensor chip for sensing magnetic fields is arranged and the sensor cell is not covered by the encapsulation material. The sensor device further comprises a layer of biomolecules that are arranged on the sensor cell and wherein said biomolecules are designed to capture a specific genetic or biochemical material present in a sample to then perform the subsequent anchoring of magnetic particles modified with the same capture biomolecules. Thus, the target genetic or biochemical material will be detected by analysing the magnetic field disturbance of the sensor based on the magnetic particles anchored to the surface of the sensor in a manner that is directly proportional to the amount of the target genetic or biochemical material present in the sample.

Classes IPC  ?

• C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p.ex. par des compteurs de colonies

Abrégé

The present invention relates to a system for housing laboratory animals, which can be adapted to small animals (mice, rats, hamsters, guinea pigs, gerbils) or medium-size animals (rabbits, ferrets). For small animals, five peripheral trays (2) which each comprise a trough (21) are used, in addition to a separate trough (11). These six structures are arranged radially, thereby providing a central hexagonal tray (1) in communication with the peripheral trays (2) by means of a contact hole (3) located in a central wall (23) of each peripheral tray (2). For medium-size animals, the troughs (21) are eliminated and the separate trough (11) is replaced by a sixth peripheral tray (2). In both cases, the six elements are fitted, by means of bottom flanges, into grooves (61) made in a base plate (6).

Classes IPC  ?

• A01K 1/03 - Logements pour animaux domestiques ou de laboratoire

Abrégé

Electronic devices are available on the market with a multitude of forms and applications that essentially supply information from a transmitter/receiver. It is usually necessary for these devices to be linked to other compatible equipment. In order to prevent health problems due to poor posture, it is desirable for these devices to incorporate a simple system which allows the ergonomic posture of both the eyes and the body to be monitored and which does not have to be linked to other devices. The present invention relates to a simple accessory, without connections to other devices, for monitoring the posture of the eyes and body, incorporating accelerometers for calculating the position of the body and vibration sensors as a warning system.

Classes IPC  ?

• A61B 5/103 - Dispositifs de mesure pour le contrôle de la forme, du dessin, de la dimension ou du mouvement du corps ou de parties de celui-ci, à des fins de diagnostic
• A61B 5/11 - Mesure du mouvement du corps entier ou de parties de celui-ci, p.ex. tremblement de la tête ou des mains ou mobilité d'un membre

Abrégé

The present invention refers to the treatment of fungal infections or diseases by using specific affinity reagents, such as nanobodies, which specifically bind the fungal β-1,3- glucanosyltransferase gel4.

Classes IPC  ?

• A61P 31/10 - Antifongiques
• C07K 16/14 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de champignons, d'algues ou de lichens

Abrégé

A formulation comprising amphotericin B based on collapsed microparticles for administration by inhalation and which additionally comprises oligosaccharides and monosaccharides, as well as amino acids, as excipients, whereby the oligosaccharides and monosaccharides are γ-cyclodextrin and mannose, and the amino acid is leucine. The formulation can be administered using dry powder inhalers or aerosols.

Classes IPC  ?

• A61K 31/7048 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'oxygène comme hétéro-atome d'un cycle, p.ex. leucoglucosane, hespéridine, érythromycine, nystatine
• A61K 47/40 - Cyclodextrines; Leurs dérivés
• A61K 47/26 - Hydrates de carbone, p.ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharides; Leurs dérivés, p.ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
• A61K 47/18 - Amines; Amides; Urées; Composés d’ammonium quaternaire; Acides aminés; Oligopeptides ayant jusqu’à cinq acides aminés
• A61K 9/72 - Préparations médicinales caractérisées par un aspect particulier à fumer ou inhaler
• A61P 31/10 - Antifongiques

Abrégé

Bullet-proof vests consisting of polymeric shielding change their properties over time, as they are subjected to conditions of humidity, temperature, light, body heat, among others. This affects their resistance to the impact of a bullet, and therefore their reliability as protective systems. To discover their deterioration with the passage of time, ageing tests are usually performed under controlled artificial conditions; however, the correlation between natural ageing and accelerated ageing is a highly controversial subject; a method to provide reliable, objective information in real time on the condition of a protective vest would be highly desirable, in order to calculate its reliability and its remaining useful life.

Classes IPC  ?

• F41H 1/00 - Equipement de protection individuelle

Abrégé

Method, product and blocking element of short wavelengths in LED-type light sources consisting of a substrate with a pigment distributed on its surface and, in that said pigment has an optical density such that it allows the selective absorption of short wavelengths between 380 nm and 500 nm in a range between 1 and 99%.

Classes IPC  ?

• G02B 5/22 - Filtres absorbants
• G01J 1/42 - Photométrie, p.ex. posemètres photographiques en utilisant des détecteurs électriques de radiations
• G02B 19/00 - Condenseurs
• H01L 33/44 - DISPOSITIFS À SEMI-CONDUCTEURS NON COUVERTS PAR LA CLASSE - Détails caractérisés par les revêtements, p.ex. couche de passivation ou revêtement antireflet
• A61F 2/16 - Lentilles intraoculaires
• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
• G01J 1/02 - Photométrie, p.ex. posemètres photographiques - Parties constitutives
• H04N 9/64 - Circuits pour le traitement de signaux de couleur
• A61B 5/11 - Mesure du mouvement du corps entier ou de parties de celui-ci, p.ex. tremblement de la tête ou des mains ou mobilité d'un membre
• G02B 5/20 - Filtres
• G09F 9/33 - Dispositifs d'affichage d'information variable, dans lesquels l'information est formée sur un support, par sélection ou combinaison d'éléments individuels dans lesquels le ou les caractères désirés sont formés par une combinaison d'éléments individuels à semi-conducteurs, p.ex. à diodes
• G01J 9/00 - Mesure du déphasage des rayons lumineux; Recherche du degré de cohérence; Mesure de la longueur d'onde des rayons lumineux

Abrégé

Meyerozyma guilliermondiiM. guilliermondiiM. guilliermondiiM. guilliermondii.

Classes IPC  ?

• C12N 1/19 - Levures; Leurs milieux de culture modifiés par l'introduction de matériel génétique étranger
• A01N 63/32 - Levure

Abrégé

Method, product and blocking element of short wavelengths in LED-type light sources consisting of a substrate with a pigment distributed on its surface and, in that said pigment has an optical density such that it allows the selective absorption of short wavelengths between 380 nm and 500 nm in a range between 1 and 99%.

Classes IPC  ?

• G01J 1/02 - Photométrie, p.ex. posemètres photographiques - Parties constitutives
• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
• G01J 1/42 - Photométrie, p.ex. posemètres photographiques en utilisant des détecteurs électriques de radiations
• G02B 5/22 - Filtres absorbants
• G02B 19/00 - Condenseurs
• H04N 9/64 - Circuits pour le traitement de signaux de couleur
• A61B 5/11 - Mesure du mouvement du corps entier ou de parties de celui-ci, p.ex. tremblement de la tête ou des mains ou mobilité d'un membre
• A61F 2/16 - Lentilles intraoculaires
• G01J 9/00 - Mesure du déphasage des rayons lumineux; Recherche du degré de cohérence; Mesure de la longueur d'onde des rayons lumineux
• G02B 5/20 - Filtres
• G09F 9/33 - Dispositifs d'affichage d'information variable, dans lesquels l'information est formée sur un support, par sélection ou combinaison d'éléments individuels dans lesquels le ou les caractères désirés sont formés par une combinaison d'éléments individuels à semi-conducteurs, p.ex. à diodes
• H01L 33/44 - DISPOSITIFS À SEMI-CONDUCTEURS NON COUVERTS PAR LA CLASSE - Détails caractérisés par les revêtements, p.ex. couche de passivation ou revêtement antireflet

Abrégé

The invention relates to a method for finishing artificial slopes, for controlling surface water erosion and for promoting the revegetation (or natural plant colonisation) of these surfaces, by making parallel and continuous furrows (1), oriented according to the maximum gradient of the slope. The base of the furrows (1) may have a secondary cut intended for decompacting the soil in the desired manner. The invention also relates to bucket teeth for earth and rock moving machines with which to carry out this method.

Classes IPC  ?

• E02D 17/20 - Stabilisation de talus ou de rampes
• E02F 9/28 - Petites pièces métalliques pour éléments de creusement, p.ex. dents

Abrégé

The present invention discloses a device enabling the measurement of the apparent temperature felt by a subject in the face of different stimuli. Hitherto, it has only been possible to measure apparent temperature in a qualitative manner, using measurement methods that present difficulties. The present invention discloses an innovative method and device to quantify the thermal sensations of a subject, and reveals how the subject interprets the apparent temperature felt, and how he/she conceptualises the physical magnitudes related to that sensation. To this end, measurements are taken that link neuroreceptive data and statements by the subject concerning these thermal concepts, in such a way that it is possible to quantify the perception of temperature by the continuous collection of data, eliminating subjectivity and enabling the establishment of a link between different variables such as sensations, verbalisations, and quantitative and qualitative scales.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
• G16H 10/20 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des essais ou des questionnaires cliniques électroniques

Abrégé

A tool and method for the decompaction of the surface of slopes. The present invention relates to a tool for preparing the soil during the completion stage of the construction of slopes and other slope maintenance operations, particularly that of aiding revegetation and reducing erosion. The tool presents a roller (1) into which diametrically symmetric rods (8) are inserted, forming pairs of spikes (2), asymmetric diametrical rods (7) or radial rods (6) that generate spikes (2) that project from the surface of the roller (1). The roller is inserted into a fork (4) by means of bearings (3) that enable it to rotate freely, with no need for mechanical traction and elements for the coupling thereof to the articulated arm of a civil works or agricultural machine. The invention likewise relates to a method for preparing or maintaining the surface of slopes that includes the use of the tool of the invention.

Classes IPC  ?

• E02D 17/20 - Stabilisation de talus ou de rampes
• A01B 45/02 - Machines pour le traitement des prairies ou des pelouses pour aérer

Abrégé

22 at ambient temperature, an active layer of said sensor comprising a few-layer graphene material. The response of the sensor is not altered by relative humidity, and the sensor also demonstrates very low interference with ammonia, allowing this interference to be disregarded in the measurements.

Classes IPC  ?

• G01N 27/04 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance en recherchant la résistance
• C01B 32/182 - Graphène

Abrégé

Structurally simple organic compounds with antitumour activity by acting on mitochondria through various action mechanisms hold substantial promise for development as cancer treatment agents. The present invention relates to new compounds with F-BODIPY structure capable of specific accumulation in mitochondria, of exhibiting photocytotoxicity without the need to involve heavy atoms or other functional residues capable of interacting in biological processes, and with the potential for developing new teragnostic agents for clinical use. Furthermore, it relates to their obtainment process and their application as fluorescent markers of mitochondria, and as photocytotoxic agents for photodynamic therapy (PDT) and phototheragnostics based on mitochondrial accumulation.

Classes IPC  ?

• C07F 5/02 - Composés du bore
• C09B 57/00 - Autres colorants synthétiques de structure connue
• C09K 11/07 - Substances luminescentes, p.ex. électroluminescentes, chimiluminescentes contenant des substances organiques luminescentes ayant des constituants réagissant chimiquement entre eux, p.ex. compositions chimi-luminescentes réactives

Abrégé

A synthetic multi-epitope chimera as a vaccine and treatment against leishmaniasis in mammals. Synthetic chimera which includes four multi-epitope peptides against Leishmania. Each of the peptides has been selected from a Leishmania infantum protein. These are nucleosomal histones H2A, H2B, H3 and H4. The invention also relates to a pharmaceutical composition which includes the synthetic chimera. It also concerns a prophylactic and/or therapeutic vaccine against Leishmania spp. for use in mammals and especially in humans and dogs.

Classes IPC  ?

• C07K 19/00 - Peptides hybrides
• C12N 15/30 - Gènes codant pour des protéines protozoaires, p.ex. Plasmodium, Trypanosoma, Eiméria
• A61K 39/008 - Antigènes de Leishmania
• A61P 37/02 - Immunomodulateurs

Abrégé

in vitroin vitro in vitro wherein the new mutation has been corrected, as well as kits that include the guide pairs used in the CRISPR/Cas9 method to recover the expression of the F5 gene with said mutation.

Classes IPC  ?

• A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiques; Thérapie génique
• C12N 15/90 - Introduction stable d'ADN étranger dans le chromosome
• C12N 5/22 - Cellules humaines
• A61P 7/02 - Agents antithrombotiques; Anticoagulants; Anti-agrégants plaquettaires
• C07K 14/745 - Facteurs de coagulation sanguine ou de fibrinolyse

Abrégé

The present invention describes a chemical composition that solves the progressive loss of antisepsis of biocidal agents for antiseptic use. This composition is a unique combination of three biocidal substances, free from any adverse or harmful effects and with legally recognised indication and action. It consists of a unique combination of three biocidal substances and water wherein one biocidal agent is an alcohol, another biocidal agent is a halogenated compound, and a third substance is an antimicrobial food additive. The immediate and sustained antiseptic effectiveness of the hydroalcoholic formulation described is far superior to other commonly used antiseptics on the market. The antiseptic may be used for domestic or sanitary purposes.

Classes IPC  ?

• A61K 8/34 - Alcools
• A61K 8/43 - Guanidines
• A61K 8/36 - Acides carboxyliques; Leurs sels ou anhydrides
• A61P 31/02 - Antiseptiques locaux
• A61Q 19/10 - Préparations pour le nettoyage ou le bain

Abrégé

A method and system for the implementation thereof is disclosed, which rapidly provides simultaneous information on the functioning of both the external and internal retina. It comprises the brief dazzling of the eye of a subject with a light source, to cause a temporary insensitivity to contrast, and to psychophysically, automatedly measure the contrast during a period of time and the moment in time when said subject detects successive visual stimuli, modulated in contrast and presented against a background of mesopic luminance. The responses provided by the subject during the recovery of the contrast sensitivity, measured by the cones of the retina, are recorded in order to obtain distinguishing parameters of this dynamics of recovery, and to compare them with a standardised database to detect disturbances in visual function typical of neurodegenerative diseases of the retina.

Classes IPC  ?

• A61B 3/06 - Appareils pour l'examen optique des yeux; Appareils pour l'examen clinique des yeux du type à mesure subjective, c. à d. appareils de d’examen nécessitant la participation active du patient pour examen de vision des couleurs
• A61B 3/02 - Appareils pour l'examen optique des yeux; Appareils pour l'examen clinique des yeux du type à mesure subjective, c. à d. appareils de d’examen nécessitant la participation active du patient
• A61B 3/024 - Appareils pour l'examen optique des yeux; Appareils pour l'examen clinique des yeux du type à mesure subjective, c. à d. appareils de d’examen nécessitant la participation active du patient pour la détermination du champ de vision, p.ex. périmètres

Abrégé

The invention relates to a refractive surface for blocking short- and medium-wavelength visible-spectrum radiation that affects human physiology. The refractive surface selectively absorbs short wavelengths between 380 nm and 500 nm, between a maximum and a minimum absorption threshold, and selectively absorbs medium wavelengths between 500 nm and 590 nm, between a maximum and a minimum absorption threshold, the selective absorption of short and medium wavelengths between 380 nm and 590 nm not completely blocking the passage of visible light in this range. Other embodiments include an LED screen, a software product and an electronic device, and ophthalmic, intraocular or sunglass lenses.

Classes IPC  ?

• G09G 3/00 - Dispositions ou circuits de commande présentant un intérêt uniquement pour l'affichage utilisant des moyens de visualisation autres que les tubes à rayons cathodiques
• G02B 5/22 - Filtres absorbants
• A61F 9/06 - Masques, écrans ou cagoules pour soudeurs
• G02C 7/10 - Filtres, p.ex. pour faciliter l'adaptation des yeux à l'obscurité; Lunettes de soleil

Abrégé

The automatic detection of emotions via eating habits. Emotional states are related to eating patterns that affect us in our daily lives. For this reason, it is of interest to develop models that relate emotions with eating behaviour and changes therein. Most of the models require an interpretation of the emotion by the subject himself or by an observer. The present invention proposes the automatic detection of the user's emotion by using the so-called "Internet of Things". Specifically, the method is based on the use of a smart kitchen cupboard equipped with sensors and a data processing board capable of detecting the user's eating habit behaviour or changes therein, based on the food removed from the cupboard by the user.

Classes IPC  ?

• G06F 9/44 - Dispositions pour exécuter des programmes spécifiques
• G06F 7/00 - Procédés ou dispositions pour le traitement de données en agissant sur l'ordre ou le contenu des données maniées
• G06N 5/00 - Agencements informatiques utilisant des modèles fondés sur la connaissance
• G05B 15/02 - Systèmes commandés par un calculateur électriques

Abrégé

The present invention relates to a non-human animal model of chronic glaucoma. In addition, the invention refers to a method for the preparation of said animal model, as well as to the use thereof.

Classes IPC  ?

• A01K 67/027 - Nouvelles races de vertébrés
• A61K 9/16 - Agglomérés; Granulés; Microbilles
• A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrène; Leurs dérivés, p.ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p.ex. prégnane ou progestérone substitués en position 21, p.ex. cortisone, dexaméthasone, prednisone ou aldostérone
• C07K 14/78 - Peptides du tissu connectif, p.ex. collagène, élastine, laminine, fibronectine, vitronectine, globuline insoluble à froid (CIG)

Abrégé

The invention relates to germacrone derivatives that exhibit biocidal activity and can be used as antifeedants. In particular, it has been proven that these derivatives exhibit greater activity than germacrone in relation to certain types of mites and insects.

Classes IPC  ?

• A01N 35/06 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques comportant un atome de carbone possédant deux liaisons à des hétéro-atomes, avec au plus une liaison à un ha contenant des groupes cétone ou thiocétone faisant partie d'un cycle, p.ex. cyclohexanone, quinone; Leurs dérivés, p.ex. cétals
• A01N 31/06 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques de l'oxygène ou du soufre l'atome d'oxygène ou de soufre étant lié directement à un système cyclique cycloaliphatique

Abrégé

The invention relates to the production of a icephobic surface, using the sol-gel method without fluorides, on commercial polyurethane paints and describes a new method for preparing a coating having excellent icephobic characteristics. The method is simple, easy to scale, uses low-cost raw materials and can be applied to commercial polyurethane-based paints. The method comprises preparing a sol-gel that is deposited to form a heterogeneous film of drops on a smooth and homogeneous previous layer of commercial paint. The coating allows the adhesion strength of the ice to be reduced by up to 80%. The icephobic surfaces of this invention can be used to protect surfaces in various sectors, such as aeronautics, wind, energy or telecommunications, where other anti-ice systems would not be easily applicable.

Classes IPC  ?

• C09K 3/18 - Substances non couvertes ailleurs à appliquer sur des surfaces pour y minimiser l'adhérence de la glace, du brouillard ou de l'eau; Substances antigel ou provoquant le dégel pour application sur des surfaces
• C09D 183/04 - Polysiloxanes
• C09D 175/04 - Polyuréthanes

Abrégé

The invention relates to an endoprosthesis that is custom-designed as an implant to be anchored to a long bone of an animal, which is adaptable and customisable to the size of the medullary canal of the bone. The endoprosthesis comprises two parts that allow primary anchoring to the bone by pressure: a first part (1) made by additive manufacturing using polyether-ether-ketone (PEEK) or PEEK compounds with a hollow (12) interior; and a rod (2) made of surgical metal. The first part (1) includes an intramedullary zone (A) with mechanisms for secondary anchoring to the bone (cavities, tabs, ridges, helices) and an extramedullary zone (B) with an umbrella-shaped projection (3) having a proximal base on which rests the cortical bone into which the endoprosthesis is inserted, which also has elements for cancelling out the relative rotation of the rod on the PEEK part.

Classes IPC  ?

• A61F 2/78 - Moyens pour protéger les prothèses ou pour les assujettir au corps, p.ex. bandages, harnais, courroies ou bas pour moignons

Abrégé

The present invention provides a new series of compounds derived from 4-hydroxyphenyl phosphonium. The invention also relates to a pharmaceutical composition comprising the compounds and to the use thereof in the treatment or prevention of diseases caused by parasites, preferably trypanosomatid parasites. In particular, these compounds have demonstrated effectiveness in vivo for the treatment of visceral leishmaniasis in a mouse model. These diseases can occur in humans and in animals.

Classes IPC  ?

• C07F 9/54 - Composés de phosphonium quaternaire
• A61K 31/66 - Composés du phosphore

Abrégé

ncc ,, , ≥ 1.340; characterized in that at least one of the two longitudinal surfaces of the device comprises a photosensitizer covalently linked to said surface. This tubular medical device allows for the easy, rapid, and effective sterilization of its surface after irradiation with an external light source.

Classes IPC  ?

• A61L 2/08 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contact; Accessoires à cet effet utilisant des phénomènes physiques des radiations
• A61L 29/06 - Matériaux macromoléculaires obtenus autrement que par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone
• A61L 29/14 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
• A61L 29/16 - Matériaux biologiquement actifs, p.ex. substances thérapeutiques
• A61L 31/06 - Matériaux macromoléculaires obtenus autrement que par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone
• A61L 31/14 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
• A61L 31/16 - Matériaux biologiquement actifs, p.ex. substances thérapeutiques

Abrégé

The present invention relates to a method for visually identifying the degree of suitability of a sample isolated from blood for the validation of its subsequent clinical analysis, taking into consideration the degree of hemolysis of the sample. The method includes the comparison of the plasma of the sample with a degraded, continuous scale divided into seven stages that are distributed, with an equal size, from 55° to 00° and from 00° to 351°, 00° being red in the colour wheel of the double-cone model. The invention also relates to the degraded scale and to a device containing same, which can be made of different materials (for example, paper, card, foam board, plastic or metal).

Classes IPC  ?

• A61B 5/145 - Mesure des caractéristiques du sang in vivo, p.ex. de la concentration des gaz dans le sang, de la valeur du pH du sang

Abrégé

The present invention describes a tag comprising a magnetic element in the form of a microwire of 80-250 microns with giant magnetoimpedance which, when joined to an object, allows for the wireless detection of same by modulating the reflectivity of the microwire. Detection is performed by using a system that emits an electromagnetic wave that has a frequency between 1 and 20 GHz and a low frequency magnetic field (0.01-50 Hz), and detects the modulation of the reflectivity of the microwire. Thus, objects at distances greater than 1 m can be detected.

Classes IPC  ?

• G06K 19/06 - Supports d'enregistrement pour utilisation avec des machines et avec au moins une partie prévue pour supporter des marques numériques caractérisés par le genre de marque numérique, p.ex. forme, nature, code
• G01V 15/00 - Marques d'identification fixées ou associées à un objet afin de permettre la détection de l'objet
• G08B 13/24 - Déclenchement électrique par une interférence avec la distribution d'un champ électromagnétique

Abrégé

22S/Ag heterodimers with femtosecond laser pulses that lead to the formation of a protective AgCI shell. This reduces the surface traps while minimizing dot-to-medium transfer via non-radiative events. The Ag2S superdots generated as a result of this process outperform all currently available NIR-II contrast agents, enabling whole body in vivo imaging at ultra-low excitation intensities.

Classes IPC  ?

• C01G 5/00 - Composés de l'argent
• B82Y 15/00 - Nanotechnologie pour l’interaction, la détection ou l'actionnement, p.ex. points quantiques comme marqueurs en dosages protéiques ou moteurs moléculaires
• B82Y 30/00 - Nanotechnologie pour matériaux ou science des surfaces, p.ex. nanocomposites
• B82Y 40/00 - Fabrication ou traitement des nanostructures
• C01B 17/20 - Méthodes pour préparer les sulfures ou les polysulfures en général
• G01N 21/64 - Fluorescence; Phosphorescence
• A61K 49/00 - Préparations pour examen in vivo
• C09K 11/58 - Substances luminescentes, p.ex. électroluminescentes, chimiluminescentes contenant des substances inorganiques luminescentes contenant du cuivre, de l'argent ou de l'or

Abrégé

The present invention in particular relates to the field of micro- and nanoparticles, more in particular to coated nanoparticles. The coatings of the present invention in particular comprise surfactant protein B (SP-B) and one or more lipids. The invention further relates to such coated particles and compositions comprising them for use as a medicament, in particular for use in the treatment of various disorders. Furthermore, the invention provides the use of the compositions of the current invention for delivering one or more agents, such as small interfacing RNA (siRNA) molecules, to the target tissue or cells.

Classes IPC  ?

• A61K 38/17 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains
• A61P 11/00 - Médicaments pour le traitement des troubles du système respiratoire
• A61K 9/51 - Nanocapsules

Abrégé

The present invention relates to a permanent magnet that comprises hard magnetic particles and a soft magnetic structure with an aspect ratio greater than or equal to 3 and with a single-domain magnetic structure. Furthermore, the present invention relates to the method for obtaining such a magnet and to the use of such a magnet as part of a generator or a motor vehicle. The present invention belongs to the sector of magnetic materials and their industrial applications.

Classes IPC  ?

• H01F 7/02 - Aimants permanents
• H01F 41/00 - Appareils ou procédés spécialement adaptés à la fabrication ou à l'assemblage des aimants, des inductances ou des transformateurs; Appareils ou procédés spécialement adaptés à la fabrication des matériaux caractérisés par leurs propriétés magnétiques
• C25C 1/00 - Production, récupération ou affinage électrolytique des métaux par électrolyse de solutions

Abrégé

A relevant technological challenge is the low cost and abundant materials development for silicon surface passivation for applications in optoelectronic devices, in particular in solar cells by scalable industrial methods. In the present invention, a new hybrid material comprising PEDOT:PSS and transparent conducting oxide nanostructures is developed and a method is proposed to fabricate the composite material that passivates well the silicon surface to be used by means of a thin composite film of thickness below 200 nm.

Classes IPC  ?

• H01L 31/18 - Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de ces dispositifs ou de leurs parties constitutives
• H01L 31/04 - Dispositifs à semi-conducteurs sensibles aux rayons infrarouges, à la lumière, au rayonnement électromagnétique d'ondes plus courtes, ou au rayonnement corpusculaire, et spécialement adaptés, soit comme convertisseurs de l'énergie dudit rayonnement e; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de ces dispositifs ou de leurs parties constitutives; Leurs détails adaptés comme dispositifs de conversion photovoltaïque [PV]
• C09D 5/34 - Apprêts en pâte
• C09D 165/00 - Compositions de revêtement à base de composés macromoléculaires obtenus par des réactions créant une liaison carbone-carbone dans la chaîne principale; Compositions de revêtement à base de dérivés de tels polymères 
• C09D 7/61 - Adjuvants non macromoléculaires inorganiques
• C09D 7/40 - Adjuvants
• C09D 7/45 - Agents de suspension
• C09D 5/24 - Peintures électriquement conductrices

Abrégé

The present invention concerns aminobenzylguanidine derivative ligands specifically targeting neuroblastoma cells with an improved cellular uptake. The improved cellular uptake provides for the therapeutic and diagnostic use of the ligands in neuroblastoma-related diseases.

Classes IPC  ?

• A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique
• A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p.ex. émulsion, particule, complexe d’inclusion, stent ou kit
• A61P 35/00 - Agents anticancéreux

Abrégé

The present invention provides sustained release polymeric nanocapsules capable of releasing proteases such as collagenase with a controlled kinetic and a prolonged and sustainable effect over time(up to more than 10 days). Additionally, these nanocapsules protect the housed protease, preferably collagenase,against external aggressions maintaining its catalytic activity. In this way, this invention overcomes the currents problems associated with collagenase administration using a precise combination of monomers and cross-linkers, as described in the claims that allow the formation of degradable polymeric nanocapsules with collagenase embedded within. These capsules provide a sustained release of the housed enzyme thus providing a therapeutic improvement in comparison to current therapies thus decreasing the need for repeated injections or high collagenase doses.

Classes IPC  ?

• B01J 13/14 - Polymérisation, réticulation
• A61K 38/48 - Hydrolases (3) agissant sur des liaisons peptidiques (3.4)
• A61K 9/51 - Nanocapsules

Abrégé

Normal writing desks used in classrooms exist in the form of a flat table with a chair connected thereto, the desk having a fixed size for a group of students of a given age but who have different heights, preventing correct posture and ergonomics, which can be harmful in the long term. The present invention proposes a writing desk that allows height, slope and lighting to be changed, adjusting to the needs of the user. In addition, the device can be produced using lightweight materials so that same can be transported, and it can also include a computer device.

Classes IPC  ?

• A47B 83/02 - Tables et sièges combinés
• A47B 39/02 - Banquettes réglables

Abrégé

The invention relates to a method for producing an encryption system having a public key and a digital signature with polynomials of few variables, based on vector exponentiation. In the field of public key cryptography, there is a growing interest in developing encryption that is secure against current attacks and also against attacks from future quantum computers. The present invention describes a novel multivariate public key cryptosystem (MPKC) that uses a novel method for building the central reversible applications, which can be used to obtain a public key with polynomials of very few variables, thereby guaranteeing high efficiency and speed in encryption, decryption and digital signature processes.

Classes IPC  ?

• H04L 9/00 - Dispositions pour les communications secrètes ou protégées; Protocoles réseaux de sécurité

Abrégé

TrypanosomatidaeTrichomonadidaeTrichomonadidae families, such as Chagas disease, leishmaniasis and trichomoniasis.

Classes IPC  ?

• C07D 231/56 - Benzopyrazoles; Benzopyrazoles hydrogénés
• A61K 31/416 - 1,2-Diazoles condensés avec des systèmes carbocycliques, p.ex. indazole
• A61P 33/02 - Antiprotozoaires, p.ex. pour le traitement de la leishmaniose, de la trichomonase, de la toxoplasmose

Abrégé

The invention relates to a refractive surface for blocking short- and medium-wavelength visible-spectrum radiation that affects human physiology. The refractive surface selectively absorbs short wavelengths between 380 nm and 500 nm, between a maximum and a minimum absorption threshold, and selectively absorbs medium wavelengths between 500 nm and 590 nm, between a maximum and a minimum absorption threshold, the selective absorption of short and medium wavelengths between 380 nm and 590 nm not completely blocking the passage of visible light in this range. Other embodiments include an LED screen, a software product and an electronic device, and ophthalmic, intraocular or sunglass lenses.

Classes IPC  ?

• G02B 5/22 - Filtres absorbants
• A61F 9/06 - Masques, écrans ou cagoules pour soudeurs
• G02C 7/10 - Filtres, p.ex. pour faciliter l'adaptation des yeux à l'obscurité; Lunettes de soleil

Abrégé

The present invention relates to new biphenylsulfoximine compounds and, in particular, to their activity as positive allosteric modulators of the dopamine D1 receptor and to their use for the treatment of pathological states for which a stimulator of this receptor activity is indicated. The invention further relates to pharmaceutical compositions containing them and to a process for the preparation of such compounds.

Classes IPC  ?

• C07C 317/14 - Sulfones; Sulfoxydes ayant des groupes sulfone ou sulfoxyde liés à des atomes de carbone de cycles aromatiques à six chaînons
• A61K 31/222 - Esters, p.ex. nitroglycérine, sélénocyanates d'acides carboxyliques d'acides acycliques, p.ex. pravastatine avec des composés ayant des groupes aromatiques, p.ex. dipivéfrine, ibopamine
• A61P 25/16 - Antiparkinsoniens

Abrégé

Neospora caninum. In particular, the present invention relates to a protein composition comprising the proteins specified in Table A in an amount of at least about 2 times (fold change) higher than the same protein present in the whole tachyzoite, as calculated by quantitative label-free liquid chromatography-tandem mass spectrometry (LC-MS/MS).

Classes IPC  ?

• A61K 39/002 - Antigènes de protozoaires 
• A61K 39/012 - Antigènes de Coccidia
• C07K 14/44 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains provenant de protozoaires
• C12N 1/10 - Protozoaires; Leurs milieux de culture
• A61P 33/02 - Antiprotozoaires, p.ex. pour le traitement de la leishmaniose, de la trichomonase, de la toxoplasmose
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps

Abrégé

The present invention relates to a method for the diagnosis of frontotemporal dementia, a method for the diagnosis of a neurodegenerative disease, wherein the neurodegenerative disease is frontotemporal dementia or Alzheimer's disease, a method for the differential diagnosis of frontotemporal dementia and Alzheimer's, and a method for the diagnosis of Alzheimer's, said methods being based on Raman and/or infrared spectroscopy comprising recording a Raman and/or infrared spectrum of a blood sample.

Classes IPC  ?

• G01N 21/3577 - Couleur; Propriétés spectrales, c. à d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p.ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge pour l'analyse de liquides, p.ex. l'eau polluée
• G01N 21/65 - Diffusion de Raman
• G01N 33/49 - Analyse physique de matériau biologique de matériau biologique liquide de sang
• G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

The invention relates to a microorganism belonging to the micro-algae species Tetraselmis mediterranea TmmRU sp. (BEA/IDA/0062), and to the use of said strain to increase the isotope ratio 235U/238U of a solution in relation to a starting solution containing residual uranium with a lower ratio 235U/238U, as well as the method for obtaining said solution which is more enriched in 235U.

Classes IPC  ?

• C12N 1/12 - Algues unicellulaires; Leurs milieux de culture
• C02F 3/32 - Traitement biologique de l'eau, des eaux résiduaires ou des eaux d'égout caractérisé par les animaux ou végétaux utilisés, p.ex. les algues
• B01D 59/36 - Séparation par méthodes biologiques
• C22B 3/18 - Extraction de composés métalliques par voie humide à partir de minerais ou de concentrés à l'aide de micro-organismes ou d'enzymes, p.ex. de bactéries ou d'algues
• C22B 60/02 - Obtention du thorium, de l'uranium ou des autres actinides
• G21F 9/18 - Traitements par procédés biologiques
• C12R 1/89 - Algues

Produits et services

Printed matter; Bookbinding material; Photographs; Stationery; Adhesives for stationery or household purposes; Artists' materials; Paint brushes; Office requisites; Instructional and teaching material (except apparatus); Printers' type; Paper; Paperboard; Boxes of cardboard or paper; Posters; Scrapbooks; Cards; Books; Newspapers; Prospectuses; Pamphlets; Calendars; Writing instruments; Engravings; Lithographic works of art; Paintings [pictures], framed or unframed; Patterns for dressmaking; Drawings; Paper stationery; Handkerchiefs of paper; Face towels of paper; Table linen of paper; Hygienic paper; Bags [envelopes, pouches] of paper or plastics, for packaging; Garbage bags of paper or of plastics. Clothing; Footwear; Headgear; Shirts; Leather clothing; Belts [clothing]; Furs [clothing]; Gloves [clothing]; Scarves; Neckties; Hosiery; Socks; Slippers; Beach shoes; Ski boots; Athletics shoes; Underwear. Advertising; Business management; Business administration; Office functions; Direct mail advertising; Arranging newspaper subscriptions for others; Arranging subscriptions to telecommunication services for others; Presentation of goods on communication media, for retail purposes; Business management and organization consultancy; Accounting; Document reproduction; Employment agencies; Business management for freelance service providers; Computerized file management; Web site traffic optimization; Organization of exhibitions for commercial or advertising purposes; On-line advertising on a computer network; Rental of advertising time on communication media; Publication of publicity texts; Rental of advertising space; Dissemination of advertising matter; Consultancy regarding advertising communications strategy; Public relations services; Consultancy regarding public relations communications strategy; Business auditing; Commercial intermediation services. Telecommunications; Information about telecommunication; Communications by computer terminals; Communications by fibre optic networks; Radio communications; Communications by telephone; Communications by cellular phones; Providing user access to global computer networks; Provision of on-line forums; Providing access to databases; Electronic bulletin board services [telecommunications services]; Providing telecommunications connections to a global computer network; News agencies; News agencies; Rental of telecommunication equipment; Radio broadcasting; Television broadcasting; Teleconferencing services; Videoconferencing; Electronic messaging; Rental of access time to global computer networks. Education; Providing of training; Entertainment; Sporting and cultural activities; Entertainment information; Education information; Vocational retraining; Recreation facilities (Providing -); Publication of books; Library services; Providing films, not downloadable, via video-on-demand transmission services; Production of cinematographic films; Hire of televisions; Rental of show scenery; Photography; Organisation of competitions [education or entertainment]; Arranging and conducting of colloquiums; Arranging and conducting of conferences; Arranging and conducting of congresses; Arranging of exhibitions for cultural or educational purposes; Booking of seats for shows; Game services provided on-line from a computer network; Gambling; Publication of electronic books and journals on-line. Technical assessments relating to design; Scientific research; Technical research; Design of computers for others; Development of computers; Computer software design; Software development; Research and development for others; Conducting technical project studies; Architecture; Design of interior decor; Computer software design; Installation of software; Maintenance of software; Updating of computer software; Rental of software; Computer programming; Computer system analysis; Computer system design; Consultancy in the design and development of computer hardware; Digitization of documents; Software as a service [SaaS]; Cloud computing; Information technology [IT] consultancy; Server hosting; Testing [inspection] of vehicles for roadworthiness; Graphic art design; Styling [industrial design]; Authenticating works of art; Energy auditing; Electronic data storage. Legal services; Mediation; Security services for the protection of property and individuals; Marriage agencies; Conducting religious ceremonies; Horoscope casting; Funerary undertaking; Crematorium services; Night guard services; Monitoring of burglar and security alarms; Physical security consultancy; Opening of security locks; Rental of clothing; Detective agency services; Legal research; Intellectual property consultancy; Leasing of internet domain names; On-line social networking services; Baby sitting.

Abrégé

The invention relates to a material formed by a polymer substrate and a hydrogel based on vinyl-lactams and ionic methacrylates. The invention also relates to a method for producing this material and to the use thereof for cell culture and cell monolayer engineering, for preparing 3D scaffolds and manufacturing thermosensitive mechanical actuators.

Classes IPC  ?

• C08F 26/06 - Homopolymères ou copolymères de composés contenant un ou plusieurs radicaux aliphatiques non saturés, chaque radical ne contenant qu'une seule liaison double carbone-carbone et l'un au moins étant terminé par une liaison simple ou double à l'azote ou par un hétérocycle contenant de l'azote
• C08F 26/10 - N-Vinylpyrrolidone
• C08J 7/04 - Revêtement
• C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p.ex. lignées cellulaires; Tissus; Leur culture ou conservation; Milieux de culture à cet effet

Abrégé

The present invention relates to a method for obtaining neural stem cells and neural progenitor cells (NSC/NPC) from ovarian cortical tissue of pre-pubescent female mammals, without needing to add factors for inducing and/or expanding the neural line to the culture medium. The method of the invention can be used to obtain NSC/NPC after 8–21 days of incubation, improving the results by adding follicle stimulating hormone (FSH) to the culture medium. The NSC/NPC obtained using this method can be used in experimental models of in-vitro neurogenesis, in directed NSC/NPC differentiation to generate different types of nerve cells of interest in medicine for regenerating the nervous system, with use in autologous transplantation in cell therapy of neurodegenerative diseases, and to evaluate the neurotoxicity of different drugs, contaminants and chemical compounds.

Classes IPC  ?

• C12N 5/079 - Cellules neurales
• C12N 5/0797 - Cellules souches; Cellules progénitrices
• A61K 35/12 - Substances provenant de mammifères; Compositions comprenant des tissus ou des cellules non spécifiés; Compositions comprenant des cellules souches non embryonnaires; Cellules génétiquement modifiées
• A61K 35/54 - Ovaires; Ovules fécondés; Ovules; Embryons; Cellules fœtales; Cellules germinales

Abrégé

The present invention in particular relates to the field of micro- and nanoparticles, more in particular to coated nanoparticles. The coatings of the present invention in particular comprise surfactant protein B (SP-B) and one or more lipids. The invention further relates to such coated particles and compositions comprising them for use as a medicament, in particular for use in the treatment of various disorders. Furthermore, the invention provides the use of the compositions of the current invention for delivering one or more agents, such as small interfering RNA (siRNA) molecules, to the target tissue or cells.

Classes IPC  ?

• A61K 9/51 - Nanocapsules
• C07K 14/785 - Peptides du surfactif alvéolaire; Peptides du surfactif pulmonaire

Abrégé

The present disclosure relates to a memory hierarchy for a system-in-package. An example memory hierarchy is connectable to a processor via a memory management unit arranged for translating a virtual address sent by the processor into a physical address. The memory hierarchy has a data cache memory and a memory structure having at least a L1 memory array comprising at least one cluster. The memory structure comprises a first data access controller arranged for managing one or more banks of scratchpad memory of at least one of the clusters of at least the L1 memory array, comprising a data port for receiving at least one physical address and arranged for checking at run-time, for each received physical address, bits of the physical address to see if the physical address is present in the one or more banks of the at least one cluster of at least the L1 memory array.

Classes IPC  ?

• G06F 12/00 - Accès à, adressage ou affectation dans des systèmes ou des architectures de mémoires
• G06F 12/1045 - Traduction d'adresses utilisant des moyens de traduction d’adresse associatifs ou pseudo-associatifs, p.ex. un répertoire de pages actives [TLB] associée à une mémoire cache de données
• G06F 12/0897 - Mémoires cache caractérisées par leur organisation ou leur structure avec plusieurs niveaux de hiérarchie de mémoire cache
• G06F 12/1009 - Traduction d'adresses avec tables de pages, p.ex. structures de table de page
• G06F 12/0811 - Systèmes de mémoire cache multi-utilisateurs, multiprocesseurs ou multitraitement avec hiérarchies de mémoires cache multi-niveaux
• G06F 12/122 - Commande de remplacement utilisant des algorithmes de remplacement du type le moins fréquemment utilisé [LFU], p.ex. avec valeur de comptage individuelle
• G06F 12/128 - Commande de remplacement utilisant des algorithmes de remplacement adaptée aux systèmes de mémoires cache multidimensionnelles, p.ex. associatives d’ensemble, à plusieurs mémoires cache, multi-ensembles ou multi-niveaux
• G06F 12/0864 - Adressage d’un niveau de mémoire dans lequel l’accès aux données ou aux blocs de données désirés nécessite des moyens d’adressage associatif, p.ex. mémoires cache utilisant des moyens pseudo-associatifs, p.ex. associatifs d’ensemble ou de hachage
• G06F 12/08 - Adressage ou affectation; Réadressage dans des systèmes de mémoires hiérarchiques, p.ex. des systèmes de mémoire virtuelle
• G06F 12/02 - Adressage ou affectation; Réadressage

Abrégé

The invention relates to equipment for carrying out degradation tests on components exposed to molten media at a high temperature and pressure, which guarantees the maintenance of stable testing conditions over the duration thereof, in particular in terms of the influence of the gaseous medium on the reactivity of the molten medium. The equipment includes an auxiliary system for the circulation of gases, a second auxiliary system for subjecting the agitated reactor to controlled pressure cycles, as well as being provided with an external casing for the circulation of cooling agents in order to subject the exposed materials to temperature-programmed forced cooling cycles.

Classes IPC  ?

• G01N 17/00 - Recherche de la résistance des matériaux aux intempéries, à la corrosion ou à la lumière

Abrégé

A relevant technological challenge is the low cost and abundant materials development for silicon surface passivation for applications in optoelectronic devices,in particular in solar cells by scalable industrial methods. In the present invention, a new hybrid material comprising PEDOT:PSS and transparent conducting oxide nanostructures is developed and a method is proposed to fabricate the composite material that passivates well the silicon surface to be used by means of a thin composite film of thickness below 200nm.

Classes IPC  ?

• H01L 51/00 - Dispositifs à l'état solide qui utilisent des matériaux organiques comme partie active, ou qui utilisent comme partie active une combinaison de matériaux organiques et d'autres matériaux; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de tels dispositifs ou de leurs parties constitutives

Abrégé

The present invention describes a label comprising a magnetic element in the form of a micro-thread of 80-250 microns with giant magnetoimpedance which, joined to an object, allows the wireless detection of same by modulating the reflectivity of the micro-thread. Detection is performed by using a system that emits an electromagnetic wave having a frequency between 1 and 20 GHz and a low-frequency magnetic field (0.01-50 Hz), and detects the modulation of the reflectivity of the micro-thread. Thus, objects at distances greater than 1 m can be detected.

Classes IPC  ?

• G06K 1/00 - Méthodes ou dispositions pour marquer les supports d'enregistrement sous la forme numérique

Abrégé

The invention relates to the use of acylethanolamides in the production of a drug or nutraceutical for the prevention, relief and/or treatment of alcohol use disorders in general, and of alcohol poisoning or pathological intoxication, and alcohol dependence syndrome in particular.

Classes IPC  ?

• A61K 31/64 - Sulfonylurées, p.ex. glibenclamide, tolbutamide, chlorpropamide

Abrégé

A non-invasive, ring-shaped sensor (1) for determining blood oxygen saturation and heart rate of a person performing a physical exercise comprises a signal transmitter that transmits signals through the tissue and the arterial blood volume in the finger of the person, a receiver for receiving the transmitted signals and a first communication unit (4) that sends these signals wirelessly to a second communication unit (9) of a remote electronic device (7). In the device (7) the maximum lactate concentration, in the case of the performance of a progressive and intense exercise, and the training heart rate range are determined on the basis of the oxygen desaturation value in the arterial blood volume. The invention also relates to a system that comprises a sensor (1) and a device (7), as well as to the method for determining working zones using this system.

Classes IPC  ?

• A61B 5/024 - Mesure du pouls ou des pulsations cardiaques
• A61B 5/1455 - Mesure des caractéristiques du sang in vivo, p.ex. de la concentration des gaz dans le sang, de la valeur du pH du sang en utilisant des capteurs optiques, p.ex. des oxymètres à photométrie spectrale

Abrégé

The present invention describes a method for determining in real time the degree of activation of the trigeminovascular system. In particular, the invention can be applied in the field of medical devices capable of determining the activation index of the trigeminovascular system, mainly on the basis of the use of biomedical signals of hemodynamic character. The method establishes objective criteria for determining the degree of activation and is described as the result of the application of modelling and data fusion techniques. The method is also based on another type of signals, such as ambient signals, in order to improve statistically in real time the degree of activation determined.

Classes IPC  ?

• G06F 19/00 - Équipement ou méthodes de traitement de données ou de calcul numérique, spécialement adaptés à des applications spécifiques (spécialement adaptés à des fonctions spécifiques G06F 17/00;systèmes ou méthodes de traitement de données spécialement adaptés à des fins administratives, commerciales, financières, de gestion, de surveillance ou de prévision G06Q;informatique médicale G16H)
• G08B 21/02 - Alarmes pour assurer la sécurité des personnes

Abrégé

The invention relates to a method and electronic device for: detecting the light emission level that a light source emits to the ocular system of a user; measuring the user’s level of aversion to the quantity of light received in his/her ocular system, by analysing his/her ocular reaction; and comparing the level of aversion to the quantity of light received by the user’s ocular system, measured in step (b), with the level of aversion that is acceptable to said user and stored in a memory (102) of an electronic device (100).

Classes IPC  ?

• A61B 3/10 - Appareils pour l'examen optique des yeux; Appareils pour l'examen clinique des yeux du type à mesure objective, c. à d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient
• G01J 1/44 - Circuits électriques
• G01J 1/18 - Photométrie, p.ex. posemètres photographiques par comparaison avec une lumière de référence ou avec une valeur électrique de référence en utilisant des détecteurs électriques de radiations en utilisant une comparaison avec une valeur électrique de référence

Abrégé

The invention relates to a micro-composite material based on permanent magnets formed from magnetically hard ceramic particles of hexagonal ferrite and magnetically soft particles of metal alloys, and to the method for producing same by means of mechanical alloying in the presence of a coupling agent. Nanoparticle-based permanent magnets without rare earth elements have a complex and costly industrial production method. The invention describes the production of a composite material based on micro-scale (non-nano-scale) ferrite and metallic alloys, by means of mechanical grinding methods. A product is obtained using a low-cost, industrialisable, easily scalable production method, with which composite materials with favourable micro-structural and magnetic properties are obtained, said materials being characterised in that they have an increase in maximum energy product (BHmax) of up to 30% with respect to the main component of ferrite.

Classes IPC  ?

• H01F 7/02 - Aimants permanents
• H01F 41/00 - Appareils ou procédés spécialement adaptés à la fabrication ou à l'assemblage des aimants, des inductances ou des transformateurs; Appareils ou procédés spécialement adaptés à la fabrication des matériaux caractérisés par leurs propriétés magnétiques

Abrégé

The present invention relates to new protein compositions, methods for producing said protein compositions, pharmaceutical compositions comprising said protein compositions and methods for treating infections caused by Neospora caninum. In particular, the present invention relates to a protein composition comprising the proteins specified in Table A in an amount of at least about 2 times (fold change) higher than the same protein present in the whole tachyzoite, as calculated by quantitative label-free liquid chromatography-tandem mass spectrometry (LC-MS/MS).

Classes IPC  ?

• A61K 39/002 - Antigènes de protozoaires 
• C07K 14/435 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains
• C07K 14/44 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains provenant de protozoaires

Abrégé

The invention relates to two families of 5-nitroindazole derivatives that have antiparasitic properties and to the use thereof for the production of a drug, preferably for the treatment of infections caused by pathogenic protozoa from the Trypanosomatidae and Trichomonadidae families, such as Chagas disease, leishmaniasis and trichomoniasis.

Classes IPC  ?

• C07D 231/56 - Benzopyrazoles; Benzopyrazoles hydrogénés
• A61K 31/416 - 1,2-Diazoles condensés avec des systèmes carbocycliques, p.ex. indazole

Abrégé

The present invention relates to new protein compositions, methods for producing said protein compositions, pharmaceutical compositions comprising said protein compositions and methods for treating infections caused by Neospora caninum. In particular, the present invention relates to a protein composition comprising the proteins specified in Table A in an amount of at least about 2 times (fold change) higher than the same protein present in the whole tachyzoite, as calculated by quantitative label-free liquid chromatography-tandem mass spectrometry (LC-MS/MS).

Classes IPC  ?

• A61K 39/002 - Antigènes de protozoaires 
• C07K 14/435 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains
• C07K 14/44 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains provenant de protozoaires

Abrégé

The invention relates to a method for producing a cementitious composite, comprising: 1) a first step of conditioning silica nanoparticles, in which the nanoparticles are heated to a temperature of between 85-235°C for a sufficiently long time interval so as to obtain a maximum moisture content of 0,3% relative to the total weight of the material resulting from the first step; 2) a dry dispersion step, in which the nanoparticles conditioned in step 1) are dispersed over cement and in which inert grinding balls are used; 3) a step of conditioning the cementitious composite obtained in step 2), in which the grinding balls are separated from the cementitious composite produced. The invention also relates to the resulting composite, to cement derivatives comprising said composite, preferably mortars and concrete, to the production method thereof and to the use of these materials in industry.

Classes IPC  ?

• C04B 14/04 - Matières riches en silice; Silicates
• C04B 28/00 - Compositions pour mortiers, béton ou pierre artificielle, contenant des liants inorganiques ou contenant le produit de réaction d'un liant inorganique et d'un liant organique, p.ex. contenant des ciments de polycarboxylates

Abrégé

The present invention relates to a sensor that is able to perform joint measurements of electrochemical impedance and noise and of resistance to polarisation, enabling continuous, reliable control of general and localised corrosion processes. This monitoring system is suitable for low- and high-temperature industrial or process atmospheres in which a melted, gas or liquid phase is present, be it, for example, from metals, alloys, salts or glass, all in melted state.

Classes IPC  ?

• G01N 17/02 - Systèmes de mesure électro-chimique de l'action due aux intempéries, de la corrosion ou de la protection contre la corrosion
• G01N 27/02 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance

Abrégé

The invention relates to diruthenium compounds with an open-paddlewheel structure, to the stabilisation thereof, to the production method thereof, and to methods for using said compounds in the analysis of the secondary and tertiary structure of RNA, particularly in the determination of intersections between helices or the transition between helices and loops. The invention also relates to a kit containing diruthenium compounds with an open-paddlewheel structure and to the appropriate means for using same in the analysis of the structure of RNA.

Classes IPC  ?

• C07F 15/00 - Composés contenant des éléments des groupes 8, 9, 10 ou 18 de la classification périodique
• G01N 33/48 - Matériau biologique, p.ex. sang, urine; Hémocytomètres

Abrégé

The invention relates to a refractive surface for blocking short- and medium- wavelength visible-spectrum radiation that affects human physiology. The refractive surface selectively absorbs short wavelengths between 380 nm and 500 nm, between a maximum and a minimum absorption threshold, and selectively absorbs medium wavelengths between 500 nm and 590 nm, between between a maximum and a minimum absorption threshold, the selective absorption of short and medium wavelengths between 380 nm and 590 nm not completely blocking the passage of visible light in this range. Other embodiments include an LED screen, a software product and an electronic device, and ophthalmic, intraocular or sunglass lenses.

Classes IPC  ?

• A61F 9/00 - Procédés ou dispositifs pour le traitement des yeux; Dispositifs pour mettre en place des verres de contact; Dispositifs pour corriger le strabisme; Appareils pour guider les aveugles; Dispositifs protecteurs pour les yeux, portés sur le corps ou dans la main

Abrégé

The present invention relates to an in vitro method for the prognosis or prediction of the response to treatment with anti-psychotic drugs in subjects who have suffered first episode psychosis (FEP), and specifically to the use of the expression value, in a biological sample isolated from said subjects, of the ratio formed by two of the isoforms – active isoform and truncated isoform – of the receptor (TrKB) of the nerve growth factor BDNF, named TrKB-FL and TrkB-T, respectively. The present invention also describes kits and uses of same to implement the method of the invention.

Classes IPC  ?

• G01N 33/536 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec formation d'un complexe immunologique en phase liquide
• G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

The invention relates to bioactive hydrogels produced with natural-origin ingredients, which are cross-linked via electrostatic-type interactions and which include bone morphogenetic proteins (BMP), and to the method for producing said hydrogels. The invention also relates to the application of these bioactive hydrogels for producing sanitary products, pharmaceutical compositions and/or polymeric implants for bone and cartilage regeneration.

Classes IPC  ?

• A61L 27/52 - Hydrogels ou hydrocolloïdes

Abrégé

The invention relates to an optoelectronic device for determining the degree of collimation of a light beam, which can also be used for collimating beams by means of the incorporation of a collimation element (2). The device comprises a diffraction grating (3), a mask (5) including a plurality of windows (4) each having a diffraction grating, said diffraction gratings of the windows (4) being out of phase with one another, a matrix (7) of photodetectors (8), the number of which can be greater than or equal to the number of windows (4) of the mask (5) or which can be located in a matrix with two-dimensional distribution (CMOS or CCD), and one or more data processing elements (8). The invention also relates to methods for determining the degree of collimation of a light beam or for collimating a beam.

Classes IPC  ?

• G02B 27/30 - Collimateurs
• G01B 11/00 - Dispositions pour la mesure caractérisées par l'utilisation de techniques optiques
• G02B 23/10 - Télescopes ou lunettes d'approche, p.ex. jumelles; Périscopes; Instruments pour voir à l'intérieur de corps creux; Viseurs; Pointage optique ou appareils de visée comprenant des prismes ou des miroirs projetant dans le champ de vision des indications supplémentaires, p.ex. données par des collimateurs
• G01T 1/29 - Mesure effectuée sur des faisceaux de radiations, p.ex. sur la position ou la section du faisceau; Mesure de la distribution spatiale de radiations

Abrégé

The invention relates to an apparatus for carrying out degradation tests on materials exposed to melted means, which ensures continuous stable test conditions throughout the duration of the testing, in a specific manner, in terms of the influence of the gaseous medium on the reactivity of the melted medium. To this end, the apparatus has an auxiliary gas circulation system that can capture the gaseous effluents generated, condense and purge the unwanted fractions and recirculate them into the test chamber. The apparatus allows closed-loop operation with different melted media and in-line corrosion monitoring sensors can be inserted.

Classes IPC  ?

• G01N 17/00 - Recherche de la résistance des matériaux aux intempéries, à la corrosion ou à la lumière

Abrégé

The invention relates to a method for sterilising materials that have been biologically contaminated, using CO2 and water. More concretely, the invention has been devised for cases where the materials being sterilised are sensitive materials, such as electronic and optical materials and technical apparel. The invention also relates to the apparatus developed for implementing the sterilisation method according to the invention. The conditions under which the treatment is performed preserve the properties of the sterilised materials and therefore allow said materials to be reused.

Classes IPC  ?

• A01N 59/04 - Sulfure de carbone; Oxyde de carbone; Gaz carbonique

Abrégé

The invention relates to a gene construct for amplifying the response to signals that activate the cell integrity pathway (CWI) in Saccharomyces cerevisiae. It comprises a hyperactive allele of the MAPKK of this pathway, under the control of the promoter of a gene inducible by Rlm1, which involves the creation of a positive feedback loop, the stimulation of which leads to cell death. The invention also relates to the methods for detecting agents that alter the cell wall or the function of components of the pathway itself, which allows the detection of pharmacological antifungal and/or antitumour compounds.

Classes IPC  ?

• C12N 15/80 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour champignons
• C12Q 1/25 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des enzymes qui ne peuvent pas être classées dans les groupes

Abrégé

The invention relates to nanocrystalline titanium dioxide with mixing of anatase and rutile phases in proportion and/or spatial distribution controlled by means of laser irradiation. Titanium dioxide is a material with a wide range of applications for which a certain polymorphism is required, owing to which it is necessary to find methods for controlling the anatase-rutile phase transition, which allow the mixing of the two phases to be regulated. The invention also relates to the production of nanocrystalline titanium oxide with mixing of anatase and rutile phases controlled quantitatively and/or spatially with micrometric resolution by means of laser stamping. This phase control allows multifunctional and polyvalent devices to be designed on the basis of nanocrystalline titanium oxide and the different properties of the anatase and rutile phases thereof.

Classes IPC  ?

• G01N 21/65 - Diffusion de Raman
• C09C 1/36 - Composés du titane
• C01G 23/08 - Séchage; Calcination

Abrégé

Some applications of titanium oxide in the anatase phase are limited when they transition into the rutile phase when the temperature is increased, rendering of interest the existence of methods for controlling the anatase-rutile transition, which allow the mixing of the phases to be controlled and increase the range of working temperatures of the pure anatase in the form of nanoparticles. The present invention relates to the production of titanium dioxide with controlled mixing of the anatase-rutile phases based on doping with Al and Fe without incorporating other additives. The titanium oxide produced in this way can be applied to developments for catalysis, functional coatings, materials for energy, optoelectronic devices and different types of sensors.

Classes IPC  ?

• C01G 23/047 - Dioxyde de titane
• B82Y 30/00 - Nanotechnologie pour matériaux ou science des surfaces, p.ex. nanocomposites

Abrégé

The present invention shows extremely small iron oxide nanoparticles, 2 nm core size, 68Ga core-doped through a microwave driven synthesis that provides an expedited protocol with radiolabelling efficiency yield of around 90%, optimal for short half-lived isotopes. In vivo hot spot MRI (T1 weighted contrast) and PET imaging are demonstrated with unprecedented quality for iron oxide-based dual modality probes. The results incorporated herein show, for the first time, a new concept for dual-modality nanoparticle production and effective probe production with single core integration of both sources of contrast that will sury boost a large number of cardiovascular applications.

Classes IPC  ?

• H01F 1/00 - Aimants ou corps magnétiques, caractérisés par les matériaux magnétiques appropriés; Emploi de matériaux spécifiés pour leurs propriétés magnétiques
• B82Y 30/00 - Nanotechnologie pour matériaux ou science des surfaces, p.ex. nanocomposites
• A61K 49/00 - Préparations pour examen in vivo
• A61K 51/12 - Préparations contenant des substances radioactives utilisées pour la thérapie ou pour l'examen in vivo caractérisées par un aspect physique particulier, p.ex. émulsion, microcapsules, liposomes
• A61K 49/18 - Préparations de contraste pour la résonance magnétique nucléaire (RMN); Préparations de contraste pour l'imagerie par résonance magnétique (IRM) caractérisées par un aspect physique particulier, p.ex. émulsions, microcapsules, liposomes
• B82B 3/00 - Fabrication ou traitement des nanostructures par manipulation d’atomes ou de molécules, ou d’ensembles limités d’atomes ou de molécules un à un comme des unités individuelles

Abrégé

Wireless sensor for detecting pressure. The invention relates to a wireless pressure-detecting sensor comprising a closed ring of amorphous magnetoelastic microwire. The invention also relates to a device for detecting the pressure exerted by a fluid flowing through a conduit or tube that has rigid or flexible walls and comprises said sensor, and to a method used to detect the pressure in the conduit or tube.

Classes IPC  ?

• G05D 16/08 - Commande de la pression d'un liquide
• C22C 45/04 - Alliages amorphes avec le nickel ou le cobalt comme constituant majeur
• A61B 5/021 - Mesure de la pression dans le cœur ou dans les vaisseaux sanguins
• A61B 5/03 - Mesure de la pression des fluides à l'intérieur du corps autre que la pression du sang, p.ex. de la pression cérébrale
• A61F 2/06 - Vaisseaux sanguins

Abrégé

The invention relates to a calibration method for magnetic probes for magnetic needle interfacial shear rheometers, comprising: taking measurements (202) of the movement of the magnetic probe (14) in a film-free water-air interface within a range of frequencies ω; obtaining (204) the deformation/force amplitude ratio AR(ω) and the phase difference δ(ω) between the voltage σ applied to the coils (3) of the rheometer (9) and the surface deformation γ produced by the movement (d) of the magnetic probe (14); setting initial values for the unit conversion constant C and the effective elastic constant of the oscillator k; obtaining the speed profile in the sub-phase (206) by numerically solving the speed field equations; obtaining (210) a distance D(Cj, kj) between the theoretical deformation/force amplitude ratio ART ratio and the experimental deformation/force amplitude ratio ARE for different values of C and k; selecting (212) the pair (Cmin, kmin) that minimises the distance D(Cj, kj).

Classes IPC  ?

• G01N 11/16 - Recherche des propriétés d'écoulement des matériaux, p.ex. la viscosité, la plasticité; Analyse des matériaux en déterminant les propriétés d'écoulement en déplaçant un corps à l'intérieur du matériau en mesurant l'effet d'amortissement sur un corps oscillant

Abrégé

The invention relates to a roll-on device which can be used to dispense exact doses of liquid and/or semi-solid formulations onto a surface, from a multi-dose container. The invention includes a non-return valve (4) that allows a volumetric space (2) to be filled, while preventing the dose, or part of the dose, from returning into the multi-dose container. The volumetric space (2) is defined by a sphere (1) contained inside a cylinder (3) and by a base (11), and houses an exact dose of the substance of interest. In addition, the invention relates to a filler material contained in the volumetric space (2) inside the roll-on device in order to allow the application of both liquid and semi-solid formulations in exact doses and in a constant manner.

Classes IPC  ?

• B05C 1/00 - Appareillages dans lesquels un liquide ou autre matériau fluide est appliqué à la surface de l'ouvrage par contact avec un élément portant le liquide ou autre matériau fluide, p.ex. un élément poreux imprégné du liquide à appliquer sous forme de revê
• A45D 34/00 - Récipients ou accessoires spécialement conçus pour l'emploi de produits de toilette ou cosmétiques liquides, p.ex. de parfums

Abrégé

The invention relates to an established cell line of canine inflammatory mammary carcinoma, of triple-negative basal epithelial cells. The invention also relates to a method for achieving stable xenotransplants of canine inflammatory mammary carcinoma in animals for testing, and to the use of the cell line and xenotransplants in the study of both canine inflammatory mammary carcinoma and human inflammatory breast carcinoma and to the use thereof for the in vitro identification of therapeutically useful compounds for the treatment of human inflammatory breast cancer. The invention further relates to a kit for the in vitro study of canine IMC and/or human IBC, of pharmaceuticals that are potentially useful against human IBC, including the cell line of the invention.

Classes IPC  ?

• C12N 5/09 - Cellules tumorales

Abrégé

The concentration of butanol in fermentation broths is low and, consequently, butanol recovery with traditional techniques requires a large amount of energy. The invention relates to a low-energy-consumption method for the recovery of butanol. The method consists of an adsorption/desorption process using a polymer resin as an adsorbent. The desorption step is performed more efficiently and combined with condensation and decantation steps.

Classes IPC  ?

• C07C 29/74 - Séparation; Purification; Stabilisation; Emploi d'additifs
• B01D 15/00 - Procédés de séparation comportant le traitement de liquides par des adsorbants ou des absorbants solides; Appareillages pour ces procédés
• C12F 3/00 - Récupération des sous-produits

Abrégé

Method, device (100) and system (200) for detection and quantification of the variation of eye damage caused by the blue and violet light of the visible spectrum comprising the steps of detecting the incident radiation on an individual's visual system; calculating the incident radiation within the range between 380 and 500 nm; establishing at least one threshold of incident radiation within said range; detecting if at least one threshold established for said range has been exceeded; warning of the excess of at least one threshold; measuring the exposure time to incident radiation; and inferring in the different ocular structures of an individual the effect of incident radiation and warning of such effect.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
• G02B 5/22 - Filtres absorbants
• A61B 3/10 - Appareils pour l'examen optique des yeux; Appareils pour l'examen clinique des yeux du type à mesure objective, c. à d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient
• H04N 9/64 - Circuits pour le traitement de signaux de couleur
• G02B 19/00 - Condenseurs
• G01J 1/02 - Photométrie, p.ex. posemètres photographiques - Parties constitutives
• G01J 1/42 - Photométrie, p.ex. posemètres photographiques en utilisant des détecteurs électriques de radiations
• A61B 5/0205 - Evaluation simultanée de l'état cardio-vasculaire et de l'état d'autres parties du corps, p.ex. de l'état cardiaque et respiratoire
• A61B 5/024 - Mesure du pouls ou des pulsations cardiaques
• A61B 5/11 - Mesure du mouvement du corps entier ou de parties de celui-ci, p.ex. tremblement de la tête ou des mains ou mobilité d'un membre
• H01L 33/44 - DISPOSITIFS À SEMI-CONDUCTEURS NON COUVERTS PAR LA CLASSE - Détails caractérisés par les revêtements, p.ex. couche de passivation ou revêtement antireflet
• G02B 5/20 - Filtres

Abrégé

The invention relates to a novel implant based on titanium, consisting of a titanium coating formed over biomaterials, applicable in bone implantology. The nanotopographical characteristics of said implants inhibit bacterial adhesion and formation of bacterial biofilm on the surface, the implants simultaneously exhibiting suitable properties for the adhesion, extension, and proliferation of the bone-forming cells. The invention also relates to a method for producing the implant by means of oblique incidence techniques and to the use thereof in bone implantology.

Classes IPC  ?

• A61C 13/00 - Prothèses dentaires; Leurs procédés de fabrication
• A61L 27/06 - Titane ou alliages de titane
• A61L 27/30 - Matériaux inorganiques
• A61F 2/28 - Os
• C23C 14/16 - Matériau métallique, bore ou silicium sur des substrats métalliques, en bore ou en silicium
• C23C 14/35 - Pulvérisation cathodique par application d'un champ magnétique, p.ex. pulvérisation au moyen d'un magnétron

Abrégé

The invention relates to a compound material comprising inorganic salts of nitrate and chloride anions, which can also comprise sulfates, carbonates and/or nitrites and inorganic and organic nanoparticles, such as graphene, and cations of the chemical groups of the alkali metals, alkaline-earth metals, icosagens, crystallogens and/or chalcogens. Said formulations have physical and chemical characteristics, such as the heat capacity, heat stability and heat conductivity thereof, which render them optimum for using as alternatives to the commercial binary mixture in solar concentration plants.

Classes IPC  ?

• C09K 5/00 - Substances pour le transfert de chaleur, pour l'échange de chaleur ou pour le stockage de la chaleur, p.ex. réfrigérants; Substances pour la production de chaleur ou de froid par des réactions chimiques autres que la combustion
• C09K 5/12 - Substances fondues, c.à d. substances solides à température ambiante, p.ex. métaux ou sels

Abrégé

Method, product and blocking element of short wavelengths in LED-type light sources consisting of a substrate with a pigment distributed on its surface and, in that said pigment has an optical density such that it allows the selective absorption of short wavelengths between 380 nm and 500 nm in a range between 1 and 99 %.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic ; Identification des individus
• G01J 1/02 - Photométrie, p.ex. posemètres photographiques - Parties constitutives
• G01J 1/42 - Photométrie, p.ex. posemètres photographiques en utilisant des détecteurs électriques de radiations
• G02B 19/00 - Condenseurs
• H04N 9/64 - Circuits pour le traitement de signaux de couleur
• A61B 5/11 - Mesure du mouvement du corps entier ou de parties de celui-ci, p.ex. tremblement de la tête ou des mains ou mobilité d'un membre
• G02B 5/20 - Filtres
• G02B 5/22 - Filtres absorbants
• H01L 33/44 - DISPOSITIFS À SEMI-CONDUCTEURS NON COUVERTS PAR LA CLASSE - Détails caractérisés par les revêtements, p.ex. couche de passivation ou revêtement antireflet

Abrégé

The present invention refers to a prognosis method for determining the severity of autoimmune diseases, e.g. rheumatoid arthritis, spondyloarthritis and systemic lupus erythematosus, characterized in that said method detects certain genetic polymorphisms of the VIP gene found between rs35643203, rs71575932 and/or rs7755568. The method according to the invention is also useful for establishing a customized patient treatment. The invention relatse to the use of genetic polymorphisms of the VIP gene, described in the invention, as biomarkers of said diseases, as well as a kit comprising primers or probes for detecting said polymorphisms and the use thereof for the same purpose.

Classes IPC  ?

• C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques