Abstract

The invention relates to temperature-stable core-shell particles for the production of stimuli-responsive structural color materials. During processing, the cores self-assemble in the soft shell matrix, forming a photonic crystal. High temperature (processing) stability is achieved via optimizations of the particle architecture, regarding an optimized core proportion of 40 to 45 vol% and a reduced amount of cross-linker in the interlayer. The invention is further directed to a process for synthesizing said particles in starved-feed emulsion polymerization and to prepare a particle composition comprising the particles and at least one antioxidant. The invention further includes the use of the thereby obtained particle composition in common polymer processing techniques, especially 3D printing with the fused filament fabrication technique. The use of the invented particles and particle composition allows for preparing geometrically complex objects and detailed 3D structures with structural colors.

IPC Classes  ?

• C08F 285/00 - Macromolecular compounds obtained by polymerising monomers on to preformed graft polymers
• B33Y 70/00 - Materials specially adapted for additive manufacturing
• C08K 3/04 - Carbon
• C08K 5/134 - Phenols containing ester groups

Abstract

In one aspect, the disclosure relates to compounds effective in the treatment of multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis as well as drug-sensitive tuberculosis, methods of making the same, pharmaceutical compositions comprising the same, and methods of treating bacterial infections caused by Mycobacterium tuberculosis using the same. In an aspect, the compounds and pharmaceutical compositions are not cytotoxic. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

IPC Classes  ?

• C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
• A61K 31/4196 - 1,2,4-Triazoles
• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61P 31/06 - Antibacterial agents for tuberculosis
• C07D 249/12 - Oxygen or sulfur atoms
• C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
• C07D 403/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
• C07D 413/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

The invention pertains to compounds and compositions comprising inhibitors of Dickkopf like protein 3 (DKK3) for use in the treatment of lung diseases, in particular of idiopathic pulmonary fibrosis (IPF). Further provided are methods for the diagnosis, stratification, and monitoring of a therapy response of such lung diseases.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
• A61K 38/00 - Medicinal preparations containing peptides
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

The invention relates to a method for producing a dielectric elastomer actuator (10, 20) comprising an elastomer actuator film (1), the method comprising the following steps: • providing (S1, S2) the elastomer actuator film (1) which comprises a dielectric elastic polymer layer (2) coated on one side with a conductive electrode layer (3); • testing (S3) a dielectric strength of the elastomer film (1) by applying a test voltage in order to form a field intensity in the dielectric layer (2), which field intensity is below a breakdown field intensity of the material of the dielectric layer; • localising (S4) at least one breakdown point (46) using an optical method; • repairing (S5) the at least one localised breakdown point (46) by exclusively applying a curable adhesive (45) in addition to subsequent curing and/or by applying a repair film (44) to a side of the dielectric layer (2) opposite the electrode layer (3).

IPC Classes  ?

• H10N 30/02 - Forming enclosures or casings
• H10N 30/88 - MountsSupportsEnclosuresCasings
• H10N 30/05 - Manufacture of multilayered piezoelectric or electrostrictive devices, or parts thereof, e.g. by stacking piezoelectric bodies and electrodes
• H10N 30/857 - Macromolecular compositions

Abstract

characterized bycharacterized by overproduction of lysine.

IPC Classes  ?

• C12P 13/00 - Preparation of nitrogen-containing organic compounds
• C12N 9/10 - Transferases (2.)
• C12N 9/06 - Oxidoreductases (1.), e.g. luciferase acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7)
• C12N 15/77 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for CorynebacteriumVectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Brevibacterium

Abstract

The invention relates to an alloy having the following composition: NiaNi CuaCu NbbNb TabTa ZrcZr HfcHf TicTi FedFe CrdCr CodCo MndMn VeV MoeMo SnfSn AgfAg ZnfZn AlfAl SifSi GefGe SbfSb BgB CgC OhO HhH NhN Pi, with 30.00 wt.% ≤ aNi + aCu ≤ 55.00 wt.%, 35.00 wt.% ≤ bNb + bTa ≤ 68.00 wt.%, 0 wt.% ≤ cZr + cHf + cTi ≤ 12.50 wt.%, 0 wt.% ≤ dFe + dCr + dCo + dMn ≤ 8.50 wt.%, 0 wt.% ≤ eV + eMo ≤ 10.00 wt.%, 0 wt.% ≤ fSn + fAg + fZn + fAl + fSi + fGe + fSb ≤ 10.00 wt.%, 0 wt.% ≤ gB + gC ≤ 0.60 wt.%, 0 wt.% ≤ hO + hH + hN ≤ 0.10 wt.%, 0 wt.% < i ≤ 2.40 wt.%, wherein the sum of all wt.% aNi + aCu + bNb + bTa + cZr + cHf + cTi + dFe + dCr + dCo + dMn + eV + eMo + fSn + fAg + fZn + fAl + fSi + fGe + fSb + gB + gC + hO + hH + hN + i = 100 wt.% and the wt.% are each based on the total weight of the alloy, with the exception of the following alloys: Ni51,20Nb48,36P0,44, Ni51,65Nb47,47P0,88, Ni52,11Nb46,56P1,33, Ni47,58Nb50,22P2,20, Ni44,91Nb41,47Ta11,54P2,08, Ni42,52Nb33,66Ta21,85P1,97, Ni40,38Nb26,63Ta31,12P1,87, Ni36,68Nb14,51Ta47,11P1,70, Ni35,07Nb9,25Ta54,06P1,62, Ni33,59Nb4,43Ta60,42P1,56.

IPC Classes  ?

• C22C 19/03 - Alloys based on nickel or cobalt based on nickel
• C22C 27/02 - Alloys based on vanadium, niobium or tantalum
• C22C 30/00 - Alloys containing less than 50% by weight of each constituent
• C22C 45/04 - Amorphous alloys with nickel or cobalt as the major constituent
• C22C 45/10 - Amorphous alloys with molybdenum, tungsten, niobium, tantalum, titanium, or zirconium as the major constituent

Abstract

A dielectric transducer for use in a sensor, actuator or generator comprising a plurality of layers of transducer foils, wherein an electrically contactable and conductive layer forming an electrode layer is applied to at least one side of each transducer foil. Expediently, at least two contact elements are provided, each of which is arranged at least partially in a recess or in a through-channel and extends over at least one layer of transducer foils, adjacent electrode layers being electrically conductively connected to different contact elements. Since adjacent electrode layers are connected to different contact elements, intended use is possible, and bringing together several contact lines is advantageously not necessary. Furthermore, the invention relates to a method for producing a multilayer dielectric transducer for use in a sensor, an actuator or a generator, as well as an actuator, a sensor or a generator.

IPC Classes  ?

• H10N 30/87 - Electrodes or interconnections, e.g. leads or terminals
• H10N 30/057 - Manufacture of multilayered piezoelectric or electrostrictive devices, or parts thereof, e.g. by stacking piezoelectric bodies and electrodes by stacking bulk piezoelectric or electrostrictive bodies and electrodes
• H10N 30/063 - Forming interconnections, e.g. connection electrodes of multilayered piezoelectric or electrostrictive parts
• H10N 30/50 - Piezoelectric or electrostrictive devices having a stacked or multilayer structure
• H10N 30/857 - Macromolecular compositions

Abstract

The invention relates to a method for processing a separation product, containing carboxylic acids, of a separation process, in particular a process for separating fish oil and/or algae oil, in which method polyunsaturated hydrocarbons are produced at least from some of the carboxylic acids by means of microbes. Advantageously, the polyunsaturated hydrocarbons are or comprise omega-3 fatty acids and/or omega-6 fatty acids, preferably EPA, DHA and/or DPA. In an embodiment of the invention, the microbes are or comprise yeast, fungus, bacteria and/or in particular marine protists, preferably microalgae. The yeast is preferably a yeast of the Yarrowia lipolytica species and the marine protist is preferably a microalga of the Schizochytrium genus, preferably Schizochytrium limacinum SR21. The invention further relates to biomass which is produced from microbes and comprises polyunsaturated hydrocarbons.

IPC Classes  ?

• C12P 7/6432 - Eicosapentaenoic acids [EPA]
• C12P 7/6434 - Docosahexenoic acids [DHA]
• C12P 7/6427 - Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
• C12R 1/89 - Algae
• C12R 1/645 - Fungi

Abstract

The invention relates to a translatory actuation unit (1, 100), comprising: - a dielectric elastomer actuator (DEA) (3, 103), which can be brought from a non-activated state to an activated state by application of an electric voltage, with a length change occurring in at least one deflection direction (A) between two connection points; - an actuation element (5, 105) for providing an actuation travel and/or an actuation force in a translatory actuation direction (S); - a linear transmission (4, 104), which connects the DEA (3, 103) to the actuation element (5, 105) with a step-down transmission ratio or a step-up transmission ratio; - a spring device, which is mechanically coupled to the DEA (3, 103) and/or to the linear transmission (4, 104), the spring device (6, 106) having an at least partially negative spring constant characteristic, so that in the activated state a deflection in the deflection direction (A) is supported with a greater force or a smaller force counteracts the deflection than in the non-activated state.

IPC Classes  ?

• H02N 2/00 - Electric machines in general using piezoelectric effect, electrostriction or magnetostriction
• H02N 2/04 - Constructional details

Abstract

The invention relates to a system (110) comprising an input projection layer (111), at least one second digital artificial neural network (50), and at least one semiconductor chip (40) having an analogous artificial neural network (10) being mapped from a trained first digital artificial network (17) wherein the analogous electrical circuit comprises at least one input (20) being configured to receive at least one input signal and at least one output (26) being configured to provide at least one analogous output signal, wherein the analogous artificial neural network (10) electrically connects the input (20) to the output (26), wherein the semiconductor chip (40) is recursively coupled to the second digital artificial neural network (50) such that the output of the semiconductor chip (40) is provided to at least one hidden layer of the second digital artificial neural network (50) and wherein the input (20) of the semiconductor chip (40) and an input layer of the second digital artificial network (50) are electrically connected to the input projection layer (111). The invention provides a fast processing artificial neural network (10) that operates faster than the second digital artificial neural network. Thus, the analogous artificial neural network provides output to influence the operation of the second digital artificial neural network before the second digital artificial neural network provides output.

IPC Classes  ?

• G06N 3/045 - Combinations of networks
• G06N 3/063 - Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons using electronic means
• G06N 3/08 - Learning methods

Abstract

The present invention relates to compounds of formula (Ia) and the use thereof as inhibitors of P. aeruginosa virulence factor LasB. Formula (Ia). These compounds are useful in the treatment of bacterial infections, especially caused by P. aeruginosa. The present invention relates to compounds of formula (Ia) and the use thereof as inhibitors of P. aeruginosa virulence factor LasB. Formula (Ia). These compounds are useful in the treatment of bacterial infections, especially caused by P. aeruginosa.

IPC Classes  ?

• A61K 31/675 - Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 31/662 - Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
• A61K 31/428 - Thiazoles condensed with carbocyclic rings
• A61K 31/426 - 1,3-Thiazoles
• A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
• A61K 31/4406 - Non-condensed pyridinesHydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
• A61K 31/4184 - 1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles

Abstract

The invention relates to a method and a device for producing particles and to a particle dispersion.

IPC Classes  ?

• B01J 2/14 - Processes or devices for granulating materials, in generalRendering particulate materials free flowing in general, e.g. making them hydrophobic in rotating dishes or pans
• A61K 9/50 - Microcapsules
• B01J 13/04 - Making microcapsules or microballoons by physical processes, e.g. drying, spraying

Abstract

The invention relates to a device (10) for manipulating biological cells, the device (10) comprising: at least one container (22) for cultivating biological cells, the container (22) having an interior space (11), and at least one electrode (14) for manipulating the biological cells, wherein the device (10) comprises at least one separator layer (20), the at least one separator layer (20) being arranged at least between the at least one electrode (14) and the interior space (11) such that the at least one electrode (14) is arranged outside of the interior space (11). The invention further relates to a method (300) for manipulating biological cells. The invention provides a device (10) and a method (300) for manipulating biological cells that avoids the degradation of the cells in containers (22) during the manipulation of the cells with electric fields.

IPC Classes  ?

• C12M 1/32 - Inoculator or sampler multiple field or continuous type
• C12M 1/00 - Apparatus for enzymology or microbiology
• C12M 1/26 - Inoculator or sampler
• C12M 1/42 - Apparatus for the treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic wave

Abstract

Mycobacterium tuberculosisMycobacterium tuberculosis using the same. In an aspect, the compounds and pharmaceutical compositions are not cytotoxic. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

IPC Classes  ?

• A61K 31/4196 - 1,2,4-Triazoles
• A61K 31/395 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
• A61K 31/422 - Oxazoles not condensed and containing further heterocyclic rings
• A61K 31/33 - Heterocyclic compounds

Abstract

The present invention relates to a composition suitable for use as an electrolyte in a battery, comprising (i) at least one ionic liquid comprising an organic cation and (ii) at least one redox active organic compound, wherein the composition is free of solvent.

IPC Classes  ?

• H01M 8/18 - Regenerative fuel cells, e.g. redox flow batteries or secondary fuel cells

Abstract

A process of structuring a diamond substrate, comprising the steps of (a) depositing an adhesion layer on a face of the diamond substrate; (b) coating a resist layer on the adhesion layer; (c) removing parts of the resist layer so as to expose parts of the adhesion layer and form a corresponding structuring mask; (d) etching the adhesion layer and the diamond substrate (2) through the structuring mask so as to structure the diamond substrate; wherein the adhesion layer is a non-metallic compound comprising oxides.

IPC Classes  ?

• G03F 7/11 - Photosensitive materials characterised by structural details, e.g. supports, auxiliary layers having cover layers or intermediate layers, e.g. subbing layers
• C30B 33/12 - Etching in gas atmosphere or plasma
• C30B 29/04 - Diamond
• G03F 7/075 - Silicon-containing compounds
• G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor

Abstract

The present invention relates to the production of bacteriocins, and in particular the production of bacteriocins of class I or II by recombinant expression in coryneform bacteria as the bacterial cell host. Also provided are modified coryneform bacteria for use as production hosts for production of bacteriocins.

IPC Classes  ?

• A61P 31/04 - Antibacterial agents
• A61K 35/74 - Bacteria
• C12N 1/00 - Microorganisms, e.g. protozoaCompositions thereofProcesses of propagating, maintaining or preserving microorganisms or compositions thereofProcesses of preparing or isolating a composition containing a microorganismCulture media therefor

Abstract

Provided are methods in a system of at least a second and a third artificial intelligence unit, comprising: inputting first input values to at least one second artificial intelligence unit, and obtaining output values based on the input values from the at least one second artificial intelligence unit; at least temporarily storing situation data, the situation data comprising first input values and/or second output values of the at least one second unit; using the situation data as input values of the third artificial intelligence unit, the third artificial intelligence unit generating third output values in response to the input values; and checking whether the second output values of the at least one second unit satisfy one or more predetermined conditions based on the third output values. Also provided is a system for carrying out such a method.

IPC Classes  ?

• G06N 3/04 - Architecture, e.g. interconnection topology
• G06N 3/08 - Learning methods

Abstract

Provided is a method in a system of at least two artificial intelligence units, comprising inputting input values to at least a first artificial intelligence unit and a second artificial intelligence unit; obtaining first output values of the first artificial intelligence unit; forming one or more modulation functions based on the output values of the first artificial intelligence unit; applying the formed one or more modulation functions to one or more parameters of the second artificial intelligence unit, the one or more parameters influencing the processing of input values and the obtaining of output values in the second artificial intelligence unit; and finally obtaining second output values of the second artificial intelligence unit.

IPC Classes  ?

• G06N 3/04 - Architecture, e.g. interconnection topology
• G06N 3/08 - Learning methods

Abstract

The present invention provides a method for detecting structural variations (SV) within genomes of single cells or population of single cells by integrating a three-layered information of sequencing read depth, read strand orientation and haplotype phase. The method of the invention can detect deletions, duplications, polyploidies, translocations, inversions, and copy number neutral loss of heterozygosity (CNN-LOH), and more. The method of the invention can fully karyotype a genome comprehensively, and may be applied in research and clinical approaches. For example, the methods of the invention are useful for analysing cellular samples of patients for diagnosing or aiding a diagnosis, in reproductive medicine to detect embryonic abnormalities, or during therapeutic approaches based on cellular therapies to quality control genetically engineered cells, such as in adoptive T cell therapy and others. The method of the invention may further be applied in research to decipher the karyotypes of cellular models (cell lines), patient samples, or to further unravel genetic and mechanistic pathways leading to the generation of any SV within genomes.

IPC Classes  ?

• G16B 20/20 - Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
• G16B 30/00 - ICT specially adapted for sequence analysis involving nucleotides or amino acids
• G16B 50/00 - ICT programming tools or database systems specially adapted for bioinformatics

Abstract

Disclosed are Synovial Sarcoma X breakpoint 2 binding molecules and methods for their use in the detection and treatment of cancer.

IPC Classes  ?

• C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals

Abstract

A method for processing search queries directed at a database containing medical sample data and/or samples from a plurality of samples of persons comprises the steps of entering a search query with a request profile directed at retrieving at least one sample with sample data that has predetermined queried search parameters into an AI processor device, searching for at least one selected sample using the AI processor device, the at least one selected sample satisfying the request profile at least with a given probability, and outputting identification data for the at least one selected sample. A search platform device configured to process search queries directed at a database containing medical sample data and/or samples from a plurality of samples of persons is also described.

IPC Classes  ?

• G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
• G06F 17/00 - Digital computing or data processing equipment or methods, specially adapted for specific functions
• G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms

Abstract

An avatar apparatus that is designed to represent a person and to process person-related data of the person comprises an AI processor device designed for machine-learning of individual mental reaction features of the person by means of a data training, wherein the AI processor device is configured to react to questions by generating semantic responses on the basis of the mental reaction features, a first storage device that is coupled to the AI processor device and arranged to store the mental reaction features of the person, an input device that is coupled to the AI processor device and designed to interact with the person and/or to receive questions relating to the person, and an output device that is designed to output signals that represent the responses generated by the AI processor device. An avatar system having multiple avatar apparatuses, applications of the avatar apparatus and an avatar method for operating an avatar apparatus are also described.

IPC Classes  ?

• G06Q 50/00 - Information and communication technology [ICT] specially adapted for implementation of business processes of specific business sectors, e.g. utilities or tourism

Abstract

The invention relates to a method implemented in a controller of a machine for processing input values in an overall system having a working level and a rating level, comprising inputting first input values to the working level and determining first output values; forming first situation data; inputting the first situation data to the rating level and determining first ratings that indicate whether the first situation data meet predefined first conditions; influencing the determination of the first output values based on the first ratings; inputting second input values to the working level and determining second output values, wherein the determination of the second output values is influenced by the first output values; forming second situation data; inputting the second situation data to the rating level and determining second ratings that indicate whether the second situation data meet predefined second conditions, wherein the determination of the second ratings is influenced by the first ratings; influencing the determination of the second output values based on the second ratings; wherein the first and/or the second output values are used as overall output values of the overall system.

IPC Classes  ?

• G05B 19/042 - Programme control other than numerical control, i.e. in sequence controllers or logic controllers using digital processors
• B60W 30/00 - Purposes of road vehicle drive control systems not related to the control of a particular sub-unit, e.g. of systems using conjoint control of vehicle sub-units
• G05B 13/02 - Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric
• G06N 3/04 - Architecture, e.g. interconnection topology
• G06Q 50/04 - Manufacturing

Abstract

b) are provided for movement into the working position. With the at least two restoring means, a total restoring means characteristic curve, which is composed of portions of the individual, preferably preloaded restoring means as well as a portion of a variable stiffness of the actuator element, can be advantageously tailored.

IPC Classes  ?

• F03G 7/06 - Mechanical-power-producing mechanisms, not otherwise provided for or using energy sources not otherwise provided for using expansion or contraction of bodies due to heating, cooling, moistening, drying, or the like
• F16D 121/18 - Electric or magnetic
• F16K 31/02 - Operating meansReleasing devices electricOperating meansReleasing devices magnetic

Abstract

A sample collection kit (100) for collecting plant samples, in particular algae samples for biomedical applications, comprises at least one sample receptacle (10) designed to receive plant samples, a sensor arrangement (20) having multiple sensors that can be used to capture sample data, a data recording device (30) designed to record the sample data, a tool arrangement (40, 50) having collection tools, which are designed for harvesting the plant samples, and having processing tools, which are designed for processing the plant samples, a receptacle device (70) designed to receive the tool arrangement and the device arrangement in a state that is isolated from the surroundings, and identification markings (80) that contain identification data and are attached to the at least one sample receptacle, the collection tools and the processing tools, wherein there is provision for an authentication device (90) that contains an electronically readable data carrier containing authentication data that represent a state of the sample collection kit (100), and the authentication device (90) is attached to at least one from the receptacle device (70), the at least one sample container, the collection tools and the processing tools. An authentication arrangement (300) and a method for checking a state of a sample collection kit are also described.

IPC Classes  ?

• H04L 9/40 - Network security protocols
• B01L 1/00 - EnclosuresChambers
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

The present invention relates to compounds of formula (la) and the use thereof as inhibitors of P. aeruginosa virulence factor LasB. Formula (la). These compounds are useful in the treatment of bacterial infections, especially caused by P. aeruginosa.

IPC Classes  ?

• C07C 323/60 - Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
• C07D 213/74 - Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
• C07D 277/82 - Nitrogen atoms
• C07D 333/36 - Nitrogen atoms
• C07F 9/38 - Phosphonic acids [R—P(:O)(OH)2]Thiophosphonic acids
• C07F 9/40 - Esters thereof
• A61K 31/095 - Sulfur, selenium or tellurium compounds, e.g. thiols
• A61K 31/10 - SulfidesSulfoxidesSulfones
• A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
• A61K 31/426 - 1,3-Thiazoles
• A61K 31/428 - Thiazoles condensed with carbocyclic rings
• A61K 31/4406 - Non-condensed pyridinesHydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
• A61K 31/4184 - 1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
• A61P 31/04 - Antibacterial agents
• C07D 235/30 - Nitrogen atoms not forming part of a nitro radical
• C07D 277/46 - Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof

Abstract

The invention relates to a method for producing microparticles, having the steps of: A) producing a solution of a surfactant in a polar solvent, B) adding a meltable precursor of a polysiloxane-glass hybrid in order to produce a mixture of the meltable precursor and the surfactant solution, C) heating the mixture above the melting temperature of the meltable precursor in order to produce an emulsion from droplets of the meltable precursor, and D) adding a catalyst in order to initiate a crosslinking reaction on the surface of the droplets, thereby producing microparticles. The invention additionally relates to unconsolidated and consolidated microparticles which can be produced using the method, to the use of the microparticles, and to a component comprising a conversion layer comprising the microparticles.

IPC Classes  ?

• B01J 13/14 - Polymerisation, crosslinking
• A61K 9/50 - Microcapsules
• C09B 67/02 - Dyestuff preparations characterised by special physical forms, e.g. tablets, films
• C11D 3/50 - Perfumes

Abstract

The present invention relates to a method for determining a cancer therapy based on at least one antibody drug, comprising: a) determining at least one parameter selected from the absolute number of at least one receptor per cell, the mean receptor density of at least one receptor per cell, the cumulative frequency of mean receptor densities of at least one receptor per cell, the average receptor density of at least one receptor of cells of a subject and cumulative or statistical distributions thereof, b) determining the at least one antibody drug and/or a personalized dosage of the at least one antibody drug for the subject on the basis of the parameter/parameters determined in a).

IPC Classes  ?

• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
• G01N 33/563 - ImmunoassayBiospecific binding assayMaterials therefor involving antibody fragments
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• H01J 37/22 - Optical or photographic arrangements associated with the tube

Abstract

The invention relates to a method for producing a thermoelastic arrangement for an energy converter, wherein thermoelastic strand elements (6) with a constant elongation are fixed between at least two retaining elements (7, 7a, 7b) in order to obtain a bundle of strand elements (6) extending in the longitudinal direction and having identical pre-elongation.

IPC Classes  ?

• F03G 7/06 - Mechanical-power-producing mechanisms, not otherwise provided for or using energy sources not otherwise provided for using expansion or contraction of bodies due to heating, cooling, moistening, drying, or the like

Abstract

A composition precursor including a three-dimensional network consisting of partially cross-linked monomer units and an alkoxy-terminated oligo- or polysiloxane, wherein the monomer units comprise at least one trialkoxysilane and at least one dialkoxysilane. Also disclosed are a composition, a method for producing a composition precursor and a composition, use of a composition and a component.

IPC Classes  ?

• C08G 77/06 - Preparatory processes
• C08L 83/04 - Polysiloxanes
• H01L 33/56 - Materials, e.g. epoxy or silicone resin

Abstract

t).

IPC Classes  ?

• G01N 1/40 - Concentrating samples
• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups

Abstract

The invention relates to a device for removing a gas from an aqueous liquid, in particular a blood liquid, said device having: a first compartment, through which the aqueous liquid flows during operation of the device; a second compartment, through which a purge gas flows during operation of the device, the first compartment and the second compartment being separated from one another by a semi-permeable membrane; and a third compartment, through which a liquid proton donor which is an organic or inorganic acid flows during operation of the device, the first compartment and the third compartment being separated from one another by a membrane that is permeable to ions, the membrane that is permeable to ions having at least one cation conductor.

IPC Classes  ?

• B01D 63/02 - Hollow fibre modules
• A61M 1/16 - Dialysis systemsArtificial kidneysBlood oxygenators with membranes
• A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
• B01D 63/04 - Hollow fibre modules comprising multiple hollow fibre assemblies
• B01D 71/26 - Polyalkenes
• B01D 71/36 - Polytetrafluoroethene

Abstract

The invention relates to a device for the improved induction of noise by means of electromagnetic radiation, comprising: a substrate layer; a first substance, which has a reflective property with respect to electromagnetic radiation of a predetermined wavelength spectrum; and a second substance, which has an absorbing property with respect to electromagnetic radiation of the predetermined wavelength spectrum; the first substance being located in a region between the substrate layer and the second substance. A corresponding method is also provided.

IPC Classes  ?

• A61N 5/06 - Radiation therapy using light
• H04R 25/00 - Deaf-aid sets

Abstract

The invention relates to a method for operating a gas sensor system (1) having a gas sensor (3) with an active sensor surface (31) in a diagnostic mode and in a measurement mode, the following steps being carried out in the diagnostic mode: - operating (S7) the gas sensor (3) in a high-temperature phase, said high-temperature phase taking place at a temperature at which bonding of oxygen ions to points on the surface of the active sensor surface (31) is effected; - detecting (S8) a change to an electrical measurement variable, in particular electrical conductivity, of the gas sensor (3) occurring during the high-temperature phase, which change specifies an oxidation rate of an enrichment of the active sensor surface (31) with oxygen ions; - determining (S9) a degradation of the gas sensor (3) according to the profile or the change to the electrical measurement variable of the gas sensor (3); the gas sensor system (1) being operated in the measurement mode depending on the degradation.

IPC Classes  ?

• G01N 27/12 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon absorption of a fluidInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon reaction with a fluid
• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups

Abstract

The invention relates to a dielectric transducer (1; 1a; 1b) for use in a sensor, actuator or generator, comprising multiple layers of transducer foils (2, 3, 4; 2a, 3a, 4a; 2b, 3b, 4b, 20), wherein an electrically contactable and conductive layer forming an electrode layer (6, 7; 6a, 7a; 6b, 7b, 20) is applied to at least one side of each transducer foil (2, 3, 4; 2a, 3a, 4a; 2b, 3b, 4b, 20). According to the intended use, at least two contact elements (11, 12; 11a; 11b) are provided, each of which is arranged at least partially in a recess (9, 10; 9a) or in a through channel and extends over at least one layer of transducer foils (2, 3, 4; 2a, 3a, 4a; 2b, 3b, 4b, 20), wherein neighbouring electrode layers (6, 7; 6a, 7a; 6b, 7b, 20) are electrically conductively connected to different contact elements (11, 12; 11a; 11b). Given that neighbouring electrode layers are connected to different contact elements, the intended use is possible and a joining of multiple contact lines is advantageously not required. The invention also relates to a method for producing a multi-layer dielectric transducer for use in a sensor, an actuator or a generator, as well as an actuator, a sensor or a generator.

IPC Classes  ?

• H01L 41/047 - Electrodes
• H01L 41/083 - Piezo-electric or electrostrictive elements having a stacked or multilayer structure
• H01L 41/193 - Macromolecular compositions
• H01L 41/27 - Manufacturing multilayered piezo-electric or electrostrictive devices or parts thereof, e.g. by stacking piezo-electric bodies and electrodes
• H01L 41/293 - Connection electrodes of multilayered piezo-electric or electrostrictive parts

Abstract

The invention relates to a device (1) for determining a pressure acting on a surface (2) or a wall of a body (4) arranged in a flow channel (3-3b) or a change of pressure over time acting on a surface (2) or a wall of a body (4) arranged in a flow channel (3-3b), which device comprises at least one means for detecting the pressure or the change of pressure over time, the detection means having a sensor chip (5-5b) with at least one sensor (6-6b). The sensor chip (5-5b) is expediently provided in order to form a wall portion of the body (4). Advantageously the body itself does not have to be changed in order to detect a pressure acting on the surface or the wall or a change of pressure in the flow channel acting on the surface or the wall. A change to the body which influences the flow conditions, in particular in the boundary layer, is advantageously prevented. Furthermore, the invention relates to a method for producing a sensor chip (6-6b) and to a sensor chip (6-6b).

IPC Classes  ?

• G01L 9/00 - Measuring steady or quasi-steady pressure of a fluid or a fluent solid material by electric or magnetic pressure-sensitive elementsTransmitting or indicating the displacement of mechanical pressure-sensitive elements, used to measure the steady or quasi-steady pressure of a fluid or fluent solid material, by electric or magnetic means
• G01L 27/00 - Testing or calibrating of apparatus for measuring fluid pressure
• G01M 9/06 - Measuring arrangements specially adapted for aerodynamic testing

Abstract

The invention relates to a thermal actuator arrangement (1) for moving an actuator (4) between a first actuating position (S1) and a second actuating position (S2), comprising: - a first partial actuator (2) having a first thermal actuator element (21), to which a first opposing force (F1) is applied; - a second partial actuator (3) having a second thermal actuator element (31), to which a second opposing force (F2) is applied, wherein the actuator elements (21, 31) are designed to modify their shape against the opposing force (F1, F2) in each case as a result of a temperature modification; - an actuator (4), which is coupled to the first partial actuator (2) such that, when the first actuator element (21) is deactivated, the actuator (4) is held in the first actuating position (S1) when a holding force takes effect and, when the holding force (H) is eliminated, the actuator (4) moves to the second actuating position (S2) due to the effect of the first opposing force (F1); - a safety element (5), which is coupled to the second partial actuator in order to provide the holding force (H) when the second actuator element (31) is in the deactivated state and to reduce or eliminate the holding force (H) when the second actuator element (31) is in the activated state.

IPC Classes  ?

• F03G 7/06 - Mechanical-power-producing mechanisms, not otherwise provided for or using energy sources not otherwise provided for using expansion or contraction of bodies due to heating, cooling, moistening, drying, or the like

Abstract

The invention is directed to a process of structuring a diamond substrate (2), comprising the steps of (a) depositing an adhesion layer (14) on a face of the diamond substrate (2); (b) coating a resist layer (16) on the adhesion layer (14); (c) removing parts of the resist layer (16) so as to expose parts of the adhesion layer and form a corresponding structuring mask (24); (d) etching the adhesion layer (14) and the diamond substrate (2) through the structuring mask (24) so as to structure (28) said diamond substrate (2); wherein the adhesion layer (14) is a non-metallic compound comprising oxides.

IPC Classes  ?

• C30B 29/04 - Diamond
• C30B 33/12 - Etching in gas atmosphere or plasma
• G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor
• G03F 7/075 - Silicon-containing compounds
• G03F 7/11 - Photosensitive materials characterised by structural details, e.g. supports, auxiliary layers having cover layers or intermediate layers, e.g. subbing layers
• G03F 7/16 - Coating processesApparatus therefor
• G03F 7/40 - Treatment after imagewise removal, e.g. baking

Goods & Services

Scientific instruments; Computer programs for the recording and management of medical data; Software for producing study protocols, in particular study protocols for clinical trials; Software for creating standardised procedural processes, in particular standard operation procedures for clinical trials; Software for creating electronic protocols for use in clinical trials, in particular creating so-called case report forms; Computer programs for processing image data, in particular medical image data; Computer programs for processing image data by means of artificial intelligence. Data management services. Data transmission via computer networks; Providing of access to a computer network and electronic exchange of data in a computer network, in particular access to a computer program for the recording and management of medical data. Organising and arranging of training courses for the use of computer programs; Arranging of training for planning, creating, and conducting clinical trials and for good clinical practice (GCP). Electronic data storage and data back-up services, In particular storage and security of clinical trial results; Computer software for the statistical evaluation of data, in particular data from clinical trials; Experiment planning for clinical trials, in particular computerised or computer-assisted; Scientific services relating to planning, creating and conducting clinical trials, in particular for collecting or processing data for conducting clinical trials; Installation, updating, maintenance and care of computer software; Design and development of data management software; Design services for computer programs; Rental of computers and computer software for data processing; Providing electronic memory space on the Internet; Management of databases, in particular of the aforesaid, containing medical data; Scientific services relating to creating case report forms; Scientific consultancy relating to the design of clinical trials; Technical consultancy relating to the operation of software, in particular personal, by means of telephone or video chat; Processing the time process plan for clinical trials; Technical consultancy relating to data management for the non-medical sector; Graphic illustration services for others, In particular graphic presentations of the process of clinical trials.

Goods & Services

Scientific instruments; Computer programs for the recording and management of medical data; Software for producing study protocols, in particular study protocols for clinical trials; Software for creating standardised procedural processes, in particular standard operation procedures for clinical trials; Software for creating electronic protocols for use in clinical trials, in particular creating so-called case report forms; Computer programs for processing image data, in particular medical image data; Computer programs for processing image data by means of artificial intelligence. Data management services. Data transfer via a computer network; Providing of access to a computer network and electronic exchange of data in a computer network, in particular access to a computer program for the recording and management of medical data. Organising and arranging of training courses for the use of computer programs; Arranging of training for planning, creating, and conducting clinical trials and for good clinical practice (GCP). Electronic data storage and data back-up services, In particular storage and security of clinical trial results; Computer software for the statistical evaluation of data, in particular data from clinical trials; Experiment planning for clinical trials, in particular computerised or computer-assisted; Scientific services relating to planning, creating and conducting clinical trials, in particular for collecting or processing data for conducting clinical trials; Installation, updating, maintenance and care of computer software; Design and development of data management software; Design services for computer programs; Rental of computers and computer software for data processing; Providing electronic memory space on the Internet; Management of databases, in particular of the aforesaid, containing medical data; Scientific services relating to creating case report forms; Scientific consultancy relating to the design of clinical trials; Technical consultancy relating to the operation of software, in particular personal, by means of telephone or video chat; Processing the time process plan for clinical trials; Technical consultancy relating to data management for the non-medical sector; Graphic illustration services for others, In particular graphic presentations of the process of clinical trials.

Abstract

The present invention relates to an active substance delivery system, preferably an anti- cancer agent delivery system, comprising one or more active substances included in nanoparticles and a method for producing such a delivery system.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/51 - Nanocapsules
• A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers

Abstract

The invention relates to a method in a system formed by at least two artificial learning units, comprising: inputting input values at at least one first artificial learning unit and a second artificial learning unit; obtaining first output values from the first artificial learning unit; forming one or more modulation functions on the basis of the output values of the first artificial learning unit; applying the formed one or more modulation functions to one or more parameters of the second artificial learning unit, wherein the one or more parameters influence the processing of input values and the obtaining of output values in the second artificial learning unit; and finally, obtaining second output values from the second artificial learning unit.

IPC Classes  ?

• G06N 3/04 - Architecture, e.g. interconnection topology
• G06N 3/08 - Learning methods

Abstract

The invention relates to a method in a system consisting of at least one second and a third artificially learning unit, having the steps of: inputting first input values on at least one second artificially learning unit and obtaining output values based on the input values from the at least one second artificially learning unit; at least temporarily storing situation data, said situation data comprising first input values and/or second output values of the at least one second unit; using the situation data as input values for the third artificially learning unit, said third artificially learning unit generating third output values in response to the input values; and checking whether the second output values of the at least one second unit satisfy one or more specified conditions on the basis of the third output values. The invention additionally relates to a system for carrying out such a method.

IPC Classes  ?

• G06N 3/04 - Architecture, e.g. interconnection topology
• G06N 3/08 - Learning methods

Abstract

The invention relates to a thermoelastic energy converter (1), in particular for use in a thermoelastic heating/cooling apparatus or in a combined heat-and-power coupling system, comprising: - an arrangement comprising a plurality of converter devices (3a, 3b), wherein each of the converter devices (3a, 3b) has one or more thermoelastic elements (4) arranged in a direction of extension; - a loading device, in order to load the thermoelastic elements (4) of each of the plurality of converter devices (3a, 3b) so as to have a temporally variable power curve; - a coupling which is designed such that the loading device actuates the converter devices (3a, 3b) in a phase-offset manner with respect to their cyclic loading and unloading.

IPC Classes  ?

• F03G 7/06 - Mechanical-power-producing mechanisms, not otherwise provided for or using energy sources not otherwise provided for using expansion or contraction of bodies due to heating, cooling, moistening, drying, or the like
• F25B 21/00 - Machines, plants or systems, using electric or magnetic effects
• F25B 23/00 - Machines, plants or systems, with a single mode of operation not covered by groups , e.g. using selective radiation effect

Abstract

8, n are as defined in the claims and in the description. The present invention also relates to a polymer comprising in copolymerized form at least one compound of formula (I) and an organopolysiloxane and to novel compounds of formula (I).

IPC Classes  ?

• C08G 77/442 - Block- or graft-polymers containing polysiloxane sequences containing vinyl polymer sequences
• C07D 471/06 - Peri-condensed systems
• C09B 69/10 - Polymeric dyesReaction products of dyes with monomers or with macromolecular compounds
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
• H01L 33/50 - Wavelength conversion elements

Abstract

A computer-implemented method for processing a database transaction in a network of database nodes, comprising the steps: Receiving, at a first database node, instructions specifying a database transaction from a database client; determining an effect of the received instructions; among all nodes, forming a consensus on the determined effect.

IPC Classes  ?

• G06F 21/64 - Protecting data integrity, e.g. using checksums, certificates or signatures
• G06F 16/27 - Replication, distribution or synchronisation of data between databases or within a distributed database systemDistributed database system architectures therefor
• H04L 9/32 - Arrangements for secret or secure communicationsNetwork security protocols including means for verifying the identity or authority of a user of the system

Abstract

[1] The present invention provides a method for detecting structural variations (SV) within genomes of single cells or population of single cells by integrating a three-layered information of sequencing read depth, read strand orientation and haplotype phase. The method of the invention can detect deletions, duplications, polyploidies, translocations, inversions, and copy number neutral loss of heterozygosity (CNN-LOH), and more. The method of the invention can fully karyotype a genome comprehensively, and may be applied in research and clinical approaches. For example, the methods of the invention are useful for analysing cellular samples of patients for diagnosing or aiding a diagnosis, in reproductive medicine to detect embryonic abnormalities, or during therapeutic approaches based on cellular therapies to quality control genetically engineered cells, such as in adoptive T cell therapy and others. The method of the invention may further be applied in research to decipher the karyotypes of cellular models (cell lines), patient samples, or to further unravel genetic and mechanistic pathways leading to the generation of any SV within genomes.

IPC Classes  ?

• G16B 20/20 - Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
• G16B 30/10 - Sequence alignmentHomology search
• G16B 50/10 - OntologiesAnnotations

Abstract

The invention relates to an actuator (1), which can be moved from a starting position into a working position, and which has at least one actuator element (2) that can be changed with respect to its dimensions by way of an electrical signal, and in particular is made of a dielectric elastomer or a shape-memory alloy. At least two restoring means (20, 30) acting on the actuator element are provided for the movement into the working position, in particular a non-linear snap spring (20) and a linear helical spring (30). By way of the restoring means, a total restoring means characteristic curve, which is composed of portions of the individual, preferably prestressed restoring means and a portion of variable rigidity of the actuator element, can be advantageously tailored.

IPC Classes  ?

• H01L 41/09 - Piezo-electric or electrostrictive elements with electrical input and mechanical output
• H01L 41/053 - Mounts, supports, enclosures or casings
• F03G 7/06 - Mechanical-power-producing mechanisms, not otherwise provided for or using energy sources not otherwise provided for using expansion or contraction of bodies due to heating, cooling, moistening, drying, or the like

Abstract

A sulfurous, metallic glass forming alloy and a method for the production thereof are described.

IPC Classes  ?

• C22C 45/10 - Amorphous alloys with molybdenum, tungsten, niobium, tantalum, titanium, or zirconium as the major constituent
• C22C 45/00 - Amorphous alloys
• C22C 1/00 - Making non-ferrous alloys

Abstract

The present invention relates to methods for diagnosing a Parkinson's syndrome (PS), Parkinson's disease (PD), or Parkinsonism in an individual. Further, the present invention relates to a method for differential diagnosing between PD and Parkinsonism. Furthermore, the present invention relates to methods for monitoring the course of a Parkinson's syndrome, Parkinson's disease (PD), or Parkinsonism in an individual. In addition, the present invention relates to kits suitable to carry out the above described methods.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor

Abstract

The present invention relates to a method of monitoring or determining the fitness level of a subject. The present invention further relates to a method of determining the training mode of a subject. The present invention also relates to a method of optimizing personal training of a subject. In addition, the present invention relates to a kit for carrying out the above-described methods.

IPC Classes  ?

• C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
• C12Q 1/6881 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes

Abstract

144, X, n, p, q, r and s are defined in the description.

IPC Classes  ?

• C07C 391/00 - Compounds containing selenium
• A61K 31/095 - Sulfur, selenium or tellurium compounds, e.g. thiols
• A61K 31/12 - Ketones
• A61K 31/277 - NitrilesIsonitriles having a ring, e.g. verapamil
• A61P 31/04 - Antibacterial agents
• A61P 35/00 - Antineoplastic agents

Abstract

The invention relates to a modular cannula device in various embodiments, which cannula device comprises an external tubular cannula, a first tubular guide part, which has a narrowing distal end and can be inserted into the cannula such that the outer wall of the first guide part lies tightly against the inner wall of the cannula, and a second tubular guide part, which has a narrowing, tapered distal end and can be inserted into the first guide part such that the outer wall of the second guide part lies tightly against the inner wall of the first guide part.

IPC Classes  ?

• A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
• A61M 1/16 - Dialysis systemsArtificial kidneysBlood oxygenators with membranes
• A61M 25/00 - CathetersHollow probes

Abstract

The invention relates to a composition precursor comprising a three-dimensional network consisting of partially cross-linked monomer units and an alkoxy-terminated oligo- or polysiloxane, wherein the monomer units comprise at least one trialkoxysilane and at least one dialkoxysilane. The invention further relates to a composition, to a method for producing a composition precursor and to a composition, to a use of a composition and to a component.

IPC Classes  ?

• C08G 77/04 - Polysiloxanes
• C08G 77/06 - Preparatory processes
• C08L 83/04 - Polysiloxanes
• H01L 23/29 - Encapsulation, e.g. encapsulating layers, coatings characterised by the material

Abstract

The invention relates to a conversion element (100) for an optoelectronic component (1000), comprising at least one conversion material (1) that is designed for wavelength conversion, a polymer matrix material (2) produced by condensation reaction of trialkoxysilane- and dialkoxysilane monomer units (3, 4), the conversion material (1) being embedded in the matrix material (2).

IPC Classes  ?

• C08L 83/06 - Polysiloxanes containing silicon bound to oxygen-containing groups
• C09D 183/06 - Polysiloxanes containing silicon bound to oxygen-containing groups
• H01L 33/50 - Wavelength conversion elements

Abstract

The present invention is in the field of processes for the generation of thin inorganic films on substrates, in particular atomic layer deposition processes. It relates to a process for preparing metal- or semimetal-containing films comprising (a) depositing a metal- or semimetal-containing compound from the gaseous state onto a solid substrate and (b) bringing the solid substrate with the deposited metal- or semimetal-containing compound in contact with compound of general formula (II), (III), or (IV), wherein E is Ge or Sn, R is an alkyl group, an alkenyl group, an aryl group, or a silyl group, R' are an alkyl group, an alkenyl group, an aryl group, or a silyl group, X is nothing, hydrogen, a halide, an alkyl group, an alkylene group, an aryl group, an alkoxy group, an aryl oxy group, an amino group, or a amidinate group, or an guanidinate group, L is an alkyl group, an alkenyl group, an aryl group, or a silyl group.

IPC Classes  ?

• C23C 16/18 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the deposition of metallic material from metallo-organic compounds
• C23C 16/06 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the deposition of metallic material
• C23C 16/455 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for introducing gases into the reaction chamber or for modifying gas flows in the reaction chamber

Abstract

The invention relates to an apparatus (1; 1a; 1b; 1c; 1d; 1e) for producing a cast part (36) formed from an amorphous or partially amorphous metal, which comprises a cast part mold (3; 3a; 3b; 3c; 3d; 3e) having at least one fill opening (16; 16a; 16b, 41; 16c: 16d; 16e) for introducing a casting material (15; 15a; 15b; 15c; 15d; 15e) forming the cast part (36) and a device for melting the casting material (15; 15a; 15b; 15c; 15d; 15e). The melting device expediently has at least one region (13; 13; 13b; 40, 13c; 13d; 13e) which is provided for melting the casting material (15; 15a; 15b; 15c; 15d; 15e). According to the invention, an apparatus is advantageously created which enables particularly precise introduction of melt energy into the casting material. In one embodiment, the melting device has means for forming at least one electric arc (30; 30a, 39) in the at least one melting region (13; 13; 13b; 40, 13c; 13d; 13e), which particularly comprises at least two electrodes arranged at a distance from each other (32; 32a, 38; 32b; 32c), between which the at least one electric arc (30; 30a, 39) can be formed.

IPC Classes  ?

• B22D 17/12 - Cold chamber machines, i.e. with unheated press chamber into which molten metal is ladled with vertical press motion
• B22D 17/20 - AccessoriesPressure die casting or injection die casting, i.e. casting in which the metal is forced into a mould under high pressure Details
• B22D 17/28 - Melting pots
• B22D 17/30 - Accessories for supplying molten metal, e.g. in rations
• B22D 27/04 - Influencing the temperature of the metal, e.g. by heating or cooling the mould
• C22C 1/00 - Making non-ferrous alloys
• C22C 1/02 - Making non-ferrous alloys by melting

Abstract

ttt).

IPC Classes  ?

• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
• G01N 1/40 - Concentrating samples

Abstract

The present invention relates a method for detecting high grade dysplasia, for assaying the potential for the development of carcinoma and for verifying whether a sample, which was determined to contain cells with high grad dysplasia, indeed contains cells with high grade dysplasia. Further provided is the use of agents for the detection of Sec62 and Ki67 in an in vitro-method for the detection of high grade dysplasia and for the reduction of false-positive results. Furthermore, a kit for the detection of high grad dysplasia is provided as well.

IPC Classes  ?

• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer

Abstract

The present invention relates to a polynucleotide encoding NCgl0464, a host cell comprising said polynucleotide and optionally further polynucleotides. It also provides for a use of the polynucleotides, vectors or host cell for the production of glutarate and methods for producing glutarate. NCgl0464 is a 5-aminovalerate permease to be overexpressed and the further polynucleotides may encode gabT, gabA, gabB and/or gabT to be overexpressed. Also, a polynucleotide encoding lysE may be inactivated in the host cell.

IPC Classes  ?

• C12N 15/09 - Recombinant DNA-technology
• C12R 1/13 - Brevibacterium
• C07K 14/395 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from fungi from yeasts from Saccharomyces

Abstract

The present invention relates to a mi R-34a modulating compound for use in the treatment of a disease accompanied by an impaired T-cell receptor signaling. Further, the present invention relates to a method of determining whether a patient responds to a treatment of a disease accompanied by an impaired T-cell receptor signaling. Furthermore, the present invention relates to a mi R-34a binding molecule for use in the treatment of a disease accompanied by an impaired calcium signaling. In addition, the present invention relates to a method of determining whether a patient responds to a treatment of a disease accompanied by an impaired calcium signaling.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides

Abstract

The invention relates to a method for the leakage measurement of a test object (2) that is filled or can be filled with a test fluid (21), said method comprising the following steps: arranging (S1) the test object (2) in a sealed test chamber (3) filled with a reference fluid (31), in order to enrich potentially escaping test fluid (21) in the reference fluid (31) in the test chamber (3); operating (S3, S6) a fluid sensor (91, 91') that is sensitive to at least one constituent of the test fluid (21) in order to energise same with a power supply and to form a quantity of a chemical reaction partner exceeding a thermodynamic equilibrium on a sensor surface of the fluid sensor (91, 91'), the quantity of chemical reaction partner exceeding a thermodynamic equilibrium influencing an electrical property of the fluid sensor (91, 91'); following a successful energising of the fluid sensor (91, 91'), applying (S7) at least part of the reference fluid (31) potentially contaminated with test fluid (21) to the sensor surface (93) over a measurement period such that an electrical property is modified as a result of an interaction of the test fluid (21) with the reaction partners; and determining (S8, S9) a leakage indication according to the modification of the electrical property of the fluid sensor (91, 91') as a result of the application of the contaminated reference fluid (31) to the sensor surface (93).

IPC Classes  ?

• G01M 3/04 - Investigating fluid tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point
• G01M 3/18 - Investigating fluid tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using electric detection means for pipes, cables, or tubesInvestigating fluid tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using electric detection means for pipe joints or sealsInvestigating fluid tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using electric detection means for valves
• G01M 3/22 - Investigating fluid tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using special tracer materials, e.g. dye, fluorescent material, radioactive material for pipes, cables, or tubesInvestigating fluid tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using special tracer materials, e.g. dye, fluorescent material, radioactive material for pipe joints or sealsInvestigating fluid tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using special tracer materials, e.g. dye, fluorescent material, radioactive material for valves

Abstract

233-alkenyl-substituted compound of formula (I) wherein m is 1,2 or 3; Rm1, Rm2, Rm3and Rm461412461411010- alkylene; R5, R661414-aryl, or R5and R6together are a diradical of the formula A; A is a diradical of the formulae A.1 or A.2 wherein R7233-alkenyl; R8, n are are as defined in the claims and in the description. The present invention also relates to a polymer comprising in copolymerized form at least one compound of formula I and an organopolysiloxane and to novel compounds of formula (I).

IPC Classes  ?

• C07D 471/06 - Peri-condensed systems

Abstract

The present invention relates to methods for determining Alzheimer's Disease (AD) in a patient. Further, the present invention relates to uses of polynucleotides for detecting mi RNAs in a blood sample isolated from a patient for determining Alzheimer's Disease in the patient. Furthermore, the invention relates to kits for determining Alzheimer's Disease in a patient.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

The invention relates to alloys forming metallic glasses containing sulphur and a method for the production thereof.

IPC Classes  ?

• C22C 1/00 - Making non-ferrous alloys
• B22F 9/00 - Making metallic powder or suspensions thereofApparatus or devices specially adapted therefor
• C22C 45/00 - Amorphous alloys
• C22C 45/02 - Amorphous alloys with iron as the major constituent
• C22C 45/04 - Amorphous alloys with nickel or cobalt as the major constituent
• C22C 45/10 - Amorphous alloys with molybdenum, tungsten, niobium, tantalum, titanium, or zirconium as the major constituent

Abstract

The present invention relates to a method for diagnosing Parkinson's disease (PD) in an individual. Further, the present invention relates to a method for determining the course of Parkinson's disease (PD) in an individual having PD. Furthermore, the present invention relates to a method for determining the risk for developing Parkinson's disease (PD) in an individual. In addition, the present invention relates to the use of at least one polynucleotide for detecting at least one miRNA in a biological sample isolated from an individual for diagnosing Parkinson's disease (PD) in the individual, the use of at least one polynucleotide for detecting at least one miRNA in a biological sample isolated from an individual having Parkinson's disease (PD) for determining the course of PD in the individual, and/or the use of at least one polynucleotide for detecting at least one miRNA in a biological sample isolated from an individual for determining the risk of the individual to develop Parkinson's disease (PD). Moreover, the present invention relates to a kit for diagnosing Parkinson's disease (PD) in an individual, for determining the course of Parkinson's disease (PD) in an individual having PD, and/or for determining the risk for developing Parkinson's disease (PD) in an individual.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

The invention relates to a coating or a body provided with a coating. The coating is at least partly made of a composite material which comprises a porous support that has a metal core surrounded with a metal oxide. According to the invention, a polyphosphazene is bonded to the support. Expediently, the polyphosphazene is chemically bonded to the support, preferably via a covalent bond, and has poly(bis(trifluoroethoxy)phosphazene (PTFEP). In one embodiment of the invention, the support has a plurality of nanowires which are crosslinked preferably with one another. The metal of the metal oxide and the metal of the core are expediently a metal of the third main group, preferably the metal of the core is aluminum or gallium, and the metal oxide is aluminum oxide or gallium oxide. In one embodiment of the invention, the polyphosphazene coats the support, in particular the nanowires, in a thin layer such that the structure formed by the nanowires remains at least on the surface of the coating. The invention further relates to a method for producing the coating or the body.

IPC Classes  ?

• B05D 5/08 - Processes for applying liquids or other fluent materials to surfaces to obtain special surface effects, finishes or structures to obtain an anti-friction or anti-adhesive surface
• A61L 27/04 - Metals or alloys
• A61L 27/34 - Macromolecular materials
• A61L 27/50 - Materials characterised by their function or physical properties
• A61L 33/00 - Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of bloodMaterials for such treatment
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• C08G 79/025 - Polyphosphazenes
• C08L 85/02 - Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing atoms other than silicon, sulfur, nitrogen, oxygen, and carbonCompositions of derivatives of such polymers containing phosphorus
• B05D 1/18 - Processes for applying liquids or other fluent materials performed by dipping

Abstract

The invention relates to methods for diagnosing Parkinson's Disease PAD) with miRNA markers. Towards the identification of biomarkers for diagnosis of PD, a comprehensive analysis of miRNA expression patterns was obtained. Significantly deregulated miRNAs were identified.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• G16B 25/00 - ICT specially adapted for hybridisationICT specially adapted for gene or protein expression
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

Conversion of organic educts, in particular biomass feedstock, into useful organic compounds via pyrolysis and biocatalysts.

IPC Classes  ?

• C12P 7/44 - Polycarboxylic acids
• C10B 53/02 - Destructive distillation, specially adapted for particular solid raw materials or solid raw materials in special form of cellulose-containing material
• C10C 5/00 - Production of pyroligneous acid
• C07C 39/08 - Dihydroxy benzenesAlkylated derivatives thereof
• C07C 4/04 - Thermal processes
• C07C 63/26 - 1,4-Benzenedicarboxylic acid
• C07D 201/08 - Preparation of lactams from carboxylic acids or derivatives thereof, e.g. hydroxy carboxylic acids, lactones, nitriles
• C08L 77/06 - Polyamides derived from polyamines and polycarboxylic acids
• C12N 1/21 - BacteriaCulture media therefor modified by introduction of foreign genetic material
• C12N 15/01 - Preparation of mutants without inserting foreign genetic material thereinScreening processes therefor

Abstract

The present invention generally relates to the field of virology and cellular biology. Specifically, the invention provides novel means and methods for cultivating BK polyomavirus. Also provided are novel screening methods for potential inhibitors of BK polyomavirus replication.

IPC Classes  ?

• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof
• C12N 7/02 - Recovery or purification
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
• A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
• A61K 31/203 - Retinoic acids

Abstract

The present invention relates generally to a sensor for tumor tissue and a local release system for releasing therapeutic agents/diagnostic agents for targeted tumor therapy and diagnosis. More specifically, the invention relates to a cation-stabilised biopolymer gel, in particular an alginate gel, for use as a carrier matrix for a tumor therapeutic agent and/or tumor diagnostic agent, characterised in that the gel destabilises in the presence of a stimulus, in particular lysyl oxidase (LOX), generated by tumor cells or tumor tissue and the tumor therapeutic agent and/or tumor diagnostic agent can be released, and a pharmaceutical composition that comprises this cation-stabilised biopolymer gel with incorporated tumor therapeutic agent and/or tumor diagnostic agent and optionally an additional reporter substance. An associated aspect of the invention relates to an in vitro method for determining the presence and/or amount of a tumor-specific product in the body of a patient, characterised in that a physiological sample from a patient to whom a pharmaceutical composition according to the invention has been administered is examined to ascertain the presence and/or amount of a reporter substance that has been released after destabilisation of the gel as a result of contact with the tumor-specific product to be determined, and optionally compared with reference values.

IPC Classes  ?

• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• C12Q 1/26 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving oxidoreductase
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• A61P 35/00 - Antineoplastic agents

Abstract

In one embodiment the invention relates to a method of preparing a polyrotaxane, said method comprising: performing a radical copolymerization of at least (a) a first polymerizable monomer having a stopper group, and of at least (b) a second polymerizable hydrophobic monomer, wherein said second monomer is complexed by a ring-shaped molecule, and of at least (c) a third polymerizable hydrophilic monomer; wherein during said copolymerization a copolymer threading said ring-shaped molecule is formed, wherein during said copolymerization said first monomer having a stopper group is incorporated into the chain of said copolymer at least partially between the ends thereof, and wherein said stopper groups prevent said ring-shaped molecule from disassembling from the copolymer; and wherein the amount of said first monomer having a stopper group is of from 0.1 mol % to 20 mol % based on 100 mol % of the total amount of polymerizable monomers. In another embodiment the invention relates to a method of preparing a polyrotaxane, said method comprising: performing a radical copolymerization of at least (a) a first polymerizable monomer having a stopper group, and of at least (b) a second polymerizable partially hydrophilic monomer, wherein said second monomer is complexed by a ring-shaped molecule, and wherein said second monomer has a solubility in water at 20°C of from 5 g/L to 40 g/L; wherein during said copolymerization a copolymer threading said ring-shaped molecule is formed, wherein during said copolymerization said first monomer having a stopper group is incorporated into the chain of said copolymer at least partially between the ends thereof, and wherein said stopper groups prevent said ring-shaped molecule from disassembling from the copolymer; and wherein the amount of said first monomer having a stopper group is of from 0.1 mol % to 20 mol % based on 100 mol % of the total amount of polymerizable monomers. Furthermore, the present invention relates to methods of preparing cross-linked polyrotaxanes and cross-linked polyrotaxanes which can be prepared using such methods. Thus, the present invention also relates to polyrotaxane and crosslinked polyrotaxanes. The invention also relates to products which contain the polyrotaxanes or cross- linked polyrotaxanes or which can be prepared from the polyrotaxanes or the cross-linked polyrotaxanes. The present invention further relates to the use of polyrotaxanes or cross-linked polyrotaxanes in various applications, such as the use as a self-healing material.

IPC Classes  ?

• C08G 83/00 - Macromolecular compounds not provided for in groups
• C08J 3/075 - Macromolecular gels
• C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules

Abstract

The present invention is in the field of processes for the generation of thin inorganic films on substrates. In particular, the present invention relates to a process for producing an inorganic silicon-containing film comprising depositing the compound of general formula (I) onto a solid substrate, wherein R1, R2, R3 and R4 are an alkyl group, an alkenyl group, an aryl group, a silyl group, or an amine group, and wherein at least one of R1 and R2 and at least one of R3 and R4 is a branched group containing at least five non-hydrogen atoms and wherein not more than one of R1 and R2 and not more than one of R3 and R4 is an amine group.

IPC Classes  ?

• C23C 16/34 - Nitrides
• C07F 7/08 - Compounds having one or more C—Si linkages
• C23C 16/40 - Oxides
• C23C 16/455 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for introducing gases into the reaction chamber or for modifying gas flows in the reaction chamber

Abstract

The present invention relates to methods for predicting whether a pre-implanted embryo will be embedded into the endometrium of a female. The present invention further relates to a kit for predicting whether a pre-implanted embryo will be embedded into the endometrium of a female.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• C12Q 1/6888 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms

Abstract

The invention is directed to a method and a device for controlling images in a head mounted display equipped with an eye tracker and worn by a user, comprising the following steps: detecting, with the eye-tracker, an eye gaze of at least one of the eyes of the user; controlling the images depending on the detected eye gaze; wherein the step of controlling the images comprises not rendering or not updating pixels (22) of the images that are not visible by the user at the detected eye gaze.

IPC Classes  ?

• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer

Abstract

The invention relates to a refrigerated vehicle (200), which is configured for transporting samples at a temperature below - 80°C, which refrigerated vehicle comprises a refrigerated container (100) and a chassis (60) to which the refrigerated container (100) is fixedly connected, wherein the refrigerated container (100) comprises an inner container (10) enclosing an interior space (11) for receiving the samples, a refrigeration unit device (20) which is configured for passive cooling of the interior space (11), container walls (30) which delimit the inner container (10) on horizontal sides and on a base side, and a container lid (40) by which the inner container (10) can be closed on a top side of the refrigerated vehicle (100), wherein the container walls (30) have a layer structure with a plurality of wall layers which comprise at least one thermal insulation layer and an outer impact protection layer, and at least one of the container walls (30) has a hollow space which, in different operating phases of the refrigerated vehicle (200), in each case can be evacuated or can be supplied with a working gas. The invention further relates to a method for transporting samples at a temperature below -80°C by the refrigerated vehicle.

IPC Classes  ?

• F25D 3/10 - Devices using other cold materialsDevices using cold-storage bodies using liquefied gases, e.g. liquid air
• F28F 13/00 - Arrangements for modifying heat transfer, e.g. increasing, decreasing
• F25D 3/00 - Devices using other cold materialsDevices using cold-storage bodies

Abstract

The invention relates to a refrigerated container (100), which is configured for storing and/or transporting samples at a temperature below -80 °C, and which comprises an inner container (10) enclosing an interior space (11) for receiving the samples, a refrigeration unit device (20) which is configured for passive cooling of the interior space (11), container walls (30) which delimit the inner container (10) on horizontal sides and on a base side, and a container lid (40) by which the inner container (10) can be closed on a top side of the refrigerated vehicle (100), wherein the container walls (30) have a layer structure with a plurality of wall layers which comprise at least one thermal insulation layer and an outer impact protection layer, and at least one of the container walls (30) has a hollow space which, in different operating phases of the refrigerated vehicle (200), in each case can be evacuated (52) or can be supplied with a working gas (53). The invention further relates to a method for storing and/or for transporting samples at a temperature below -80°C by the refrigerated container.

IPC Classes  ?

• F25D 3/10 - Devices using other cold materialsDevices using cold-storage bodies using liquefied gases, e.g. liquid air
• F25D 3/00 - Devices using other cold materialsDevices using cold-storage bodies
• F28F 13/00 - Arrangements for modifying heat transfer, e.g. increasing, decreasing

Abstract

A white gold alloy of the composition (Au1-a-bAga(Pd1-cPtc)b)100-x-y(Cu1-d- eLdMe)x(Si1-fGef)y has been produced in which L represents In, Ga or Sn or Ld represents L1 d1L2 d2 or L1 d1L2 d2L3 d3, wherein L1, L2 and L3 are selected from the elements In, Ga, or Sn; M represents one or more elements of the elements Ni, Co, and Fe; x and y are at%, wherein x = 10 - 30 at% and y = 10 - 16.3 at%; (100-x-y), x, and y can contain unavoidable trace impurities; a, b, c, d, e, and f are a fraction of 1; a = 0.02 - 0.20, b = 0 - 0.1, c = 0 - 1, d = 0.02 -0.40, d1 = 0 to 0.4; d2 = 0 to 0.4; and d3 = 0 to 0.4, where d1 + d2 + d3 = d, e = 0 - 0.12 (total fraction of the elements Ni, Co, and Fe) and f = 0 - 0.40. The white gold alloy is suitable for a broad range of solid glass forming processes and for jewelry applications.

IPC Classes  ?

• C22C 5/02 - Alloys based on gold
• C22C 45/00 - Amorphous alloys

Abstract

In a computer-implemented method for improving the quality of medical ultrasound images, ultrasound data of a test person are obtained. The obtained data are subjected to an automated analysis as to whether a change of a parameter for detection of the ultrasound data, in particular an administration of ultrasound contrast medium to the test person, a change of the contrast setting, a signal amplification, the irradiated wavelength, or the received wavelength, improves a given quality standard of the ultrasound based on the ultrasound data. Lastly, an indicator is output to a user, based on the analysis of whether the change of the parameter improves a quality of the ultrasound data.

IPC Classes  ?

• G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)

Abstract

The invention relates to an actuator device (1) for providing at least two actuator positions, comprising an elastic bending element (2), which at at least one fastening point (31, 32, 34) is held such that by exerting a switching torque at the fastening point (31, 32, 34), an elastic deformation of the bending element (2) leads to a change from a first actuator position into a second actuator position, and comprising at least one actuator element (41, 42) having a shape memory wire, wherein by heating, the shape memory wire generates a tractive force, and is thus coupled to a section of the bending element (2) at the fastening point (31, 32, 34), such that the tractive force causes the switching moment to be brought about at the fastening point (31, 32, 34) in order to move the bending element (2) from the first actuator position into the second actuator position.

IPC Classes  ?

• F03G 7/06 - Mechanical-power-producing mechanisms, not otherwise provided for or using energy sources not otherwise provided for using expansion or contraction of bodies due to heating, cooling, moistening, drying, or the like
• G05G 1/02 - Controlling members for hand-actuation by linear movement, e.g. push buttons
• G05G 5/06 - Means for preventing, limiting or returning the movements of parts of a control mechanism, e.g. locking controlling member for holding members in one or a limited number of definite positions only
• H01L 41/09 - Piezo-electric or electrostrictive elements with electrical input and mechanical output

Abstract

In a method and an evaluation device for the evaluation of projection data of an object being examined, which are determined along a trajectory in a multiplicity of projection positions relative to a co-ordinate origin, a particular trajectory function is determined for the projection positions, for each of a multiplicity of positions from a reconstruction region of dimension n by establishing an offset (d) and a direction vector at the co-ordinate origin, establishing a hyperplane of dimension n−1 which runs perpendicular to the direction vector and has an offset to the co-ordinate origin, establishing a number of intersection points where the hyperplane intersects the trajectory, establishing a derivative vector of the trajectory according to its trajectory path and calculating the derivative vector in the projection position, and establishing an absolute value of a scalar product between the derivative vector and the position and dividing the absolute value by the number. The determined trajectory functions are transformed to a frequency domain of dimension n and the projection data are evaluated by means of the transformed trajectory functions.

IPC Classes  ?

• G06T 11/00 - 2D [Two Dimensional] image generation

Abstract

According to some aspects, a method is provided of producing multicolor objects via additive fabrication by forming a plurality of layers on a substrate from a plurality of materials each having a respective color, the method comprising obtaining image data, the image data indicating a color for each of a plurality of positions, determining a plurality of color stacks based on the image data, each color stack being determined based on the color associated with one of the plurality of positions of the image data, and each color stack specifying a sequence of materials, where each material in the sequence is selected from amongst the plurality of materials, and forming, via additive fabrication, a plurality of layers from the plurality of materials according to the specified sequence of materials associated with each color stack.

IPC Classes  ?

• B05D 5/06 - Processes for applying liquids or other fluent materials to surfaces to obtain special surface effects, finishes or structures to obtain multicolour or other optical effects
• B29C 35/08 - Heating or curing, e.g. crosslinking or vulcanising by wave energy or particle radiation
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 50/02 - Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
• H04N 1/60 - Colour correction or control

Abstract

The invention is directed to an object (2) with a three-dimensional shape made of a folded sheet (4) so as to form at least one face (6), at least one corner (10) and/or at least one edge (8), the object comprising electrically conductive traces (14) printed on the sheet (4); and at least one functional area (12) printed on one of the at least one face (6), adjacent to one of the at least one edge (8), or adjacent to one of the at least one corner (10), the at least one functional area (12) being electrically connected to the conductive traces (14) and forming at least one control for a touch input, for a display output, and/or for sensing a change of shape of the object.

IPC Classes  ?

• H05K 1/02 - Printed circuits Details
• H05K 1/11 - Printed elements for providing electric connections to or between printed circuits
• H05K 1/16 - Printed circuits incorporating printed electric components, e.g. printed resistor, capacitor, inductor
• H01G 4/33 - Thin- or thick-film capacitors
• G09F 9/30 - Indicating arrangements for variable information in which the information is built-up on a support by selection or combination of individual elements in which the desired character or characters are formed by combining individual elements
• G06F 3/044 - Digitisers, e.g. for touch screens or touch pads, characterised by the transducing means by capacitive means
• H05K 3/00 - Apparatus or processes for manufacturing printed circuits
• G06T 17/00 - 3D modelling for computer graphics
• H05K 1/03 - Use of materials for the substrate
• H05K 3/12 - Apparatus or processes for manufacturing printed circuits in which conductive material is applied to the insulating support in such a manner as to form the desired conductive pattern using printing techniques to apply the conductive material

Abstract

The present invention relates to the field of biotechnology. It involves the decomposition and conversion of organic educts, in particular biomass feedstock, lignin, guaiacol; p-coumaryl alcohol; coniferyl alcohol; sinapyl alcohol; cresol; phenol; catechol; polysaccharides; cellulose hemicellulose; xylose; glucose; fructose; proteins; amino acids; triacylglycerides and/or fatty acids into useful organic compounds with the help of biocatalysts. A method of producing an organic product comprises i) fluid-assisted decomposition of an organic educt under sub- or supercritical conditions ii) obtaining an intermediate product from step i) iii) subjecting the intermediate product to biocatalytic conversion, by contacting the intermediate product obtained in step ii) with a biocatalyst, wherein said biocatalyst is a host cell selected from the group consisting of bacteria, yeast, filamentous fungi, cyanobacteria, algae, and plant cells. Further, a host cell is provided herein that can advantageously be employed in the methods of the invention.

IPC Classes  ?

• C12P 7/10 - Ethanol, i.e. non-beverage produced as by-product or from waste or cellulosic material substrate substrate containing cellulosic material
• C12P 7/44 - Polycarboxylic acids
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase

Abstract

The present invention relates to methods for diagnosis and/or prognosis of a HPV- induced precancerous lesion or a HPV-induced cancer. Also provided are methods for detecting cells of the transition zones zone of the cervix uteri, anorectal region, oropharynx, penis or vulva. In addition, the present invention encompasses uses of LGR6, LGR5 and/or LGR4 and kits comprising means for detecting these marker(s).

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving virus or bacteriophage
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer

Abstract

The present invention relates to a method of converting an alcohol into a corresponding halide. This method comprises reacting the alcohol with an optionally substituted aromatic carboxylic acid halide in presence of an N-substituted formamide to replace a hydroxyl group of the alcohol by a halogen atom. The present invention also relates to a method of converting an alcohol into a corresponding substitution product. The second method comprises: (a) performing the method of the invention of converting an alcohol into the corresponding halide; and (b) reacting the corresponding halide with a nucleophile to convert the halide into the nucleophilic substitution product.

IPC Classes  ?

• C07C 17/16 - Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
• C07C 22/04 - Cyclic compounds containing halogen atoms bound to an acyclic carbon atom having unsaturation in the rings containing six-membered aromatic rings
• C07C 21/067 - Allyl chlorideMethallyl chloride
• C07B 39/00 - Halogenation

Abstract

The present invention relates to a method of preparing a polyrotaxane, said method comprising: performing a radical copolymerization of at least (a) a first polymerizable monomer having a stopper group, and of at least (b) a second polymerizable monomer, wherein said second monomer is complexed by a ring-shaped molecule; wherein during said copolymerization a copolymer threading said ring-shaped molecule is formed, wherein during said copolymerization said first monomer having a stopper group is incorporated into the chain of said copolymer at least partially between the ends thereof, and wherein said stopper groups prevent said ring-shaped molecule from disassembling from the copolymer; and wherein the amount of said first monomer having a stopper group is of from 0.1 mol % to 20 mol % based on 100 mol % of the total amount of polymerizable monomers. The present invention also relates to polyrotaxanes which can be prepared by using such a method. The present invention further relates to cross-linked polyrotaxanes, products which contain polyrotaxanes or cross-linked polyrotaxanes or which can be prepared from polyrotaxanes or cross- linked polyrotaxanes, and the use of polyrotaxanes or cross-linked polyrotaxanes.

IPC Classes  ?

• C08G 83/00 - Macromolecular compounds not provided for in groups
• C08F 236/04 - Copolymers of compounds having one or more unsaturated aliphatic radicals, at least one having two or more carbon-to-carbon double bonds the radical having only two carbon-to-carbon double bonds conjugated
• C08F 236/08 - Isoprene
• C08J 3/075 - Macromolecular gels
• C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules
• C08L 53/02 - Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bondsCompositions of derivatives of such polymers of vinyl aromatic monomers and conjugated dienes

Abstract

The present invention provides means and methods for diagnosing or treating B-cell malignancies. Novel conjugates for reverse targeting of B-cell receptors on malignant B cells are provided. The conjugates comprise a BCR antigen and a diagnostic or therapeutic agent. Also provided herein is a method for identifying patients disposed to respond favorably to treatment with a BCR antigen conjugate of the invention.

IPC Classes  ?

• A61K 47/48 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
• A61P 35/00 - Antineoplastic agents

Abstract

The invention relates to a method and a device for optical in vitro detection of a movement in a biological sample with a spatial extent in the form of a three-dimensional cell and/or tissue culture or a cell cluster or a sample made of freely swimming microorganisms. The method comprises the following steps: (a) providing a receptacle for the sample (1), a light beam source (6), an optical unit (7, 8) and a detector (2), (a1) wherein the optical unit (7, 8) is embodied to illuminate the whole sample (1) in the receptacle with radiation emanating from the light beam source and to guide at least some of the radiation (11) of the light beam source (6), which is changed at any point within the sample (1) by an interaction with the sample (1) in terms of the beam direction thereof, the polarization state thereof and/or the diffraction pattern thereof, to a detection surface (2a) of the detector (2), and (a2) wherein the detector (2) is embodied to generate a measurement signal (9) in a manner dependent on the detected radiation, the time profile of which measurement signal specifies a time profile of an intensity of the detected radiation (11) and/or from which the time profile of the intensity of the detected radiation (11) is derivable; (b) illuminating the sample (1) with radiation from the light beam source; and (c) detecting a movement in the biological sample (1) in a manner dependent on a temporal change in the measurement signal (9).

IPC Classes  ?

• G01N 21/21 - Polarisation-affecting properties
• G01P 13/00 - Indicating or recording presence or absence of movementIndicating or recording of direction of movement
• G01N 21/47 - Scattering, i.e. diffuse reflection
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• G01N 21/49 - Scattering, i.e. diffuse reflection within a body or fluid

Abstract

We present sandbox mining, a technique to confine an computer program to computing resources accessed during automatic testing. Sandbox mining first explores software behavior by means of automatic test generation, and extracts the set of resources accessed during these tests. This set is then used as a sandbox, blocking access to resources not used during testing. The mined sandbox thus protects against behavior changes such as the activation of latent malware, infections, targeted attacks, or malicious updates. The use of test generation makes sandbox mining a fully automatic process that can be run by vendors and end users alike.

IPC Classes  ?

• G06F 21/53 - Monitoring users, programs or devices to maintain the integrity of platforms, e.g. of processors, firmware or operating systems during program execution, e.g. stack integrity, buffer overflow or preventing unwanted data erasure by executing in a restricted environment, e.g. sandbox or secure virtual machine

Abstract

The present invention relates to a method and a device for emulating frame rates in video or motion picture.

IPC Classes  ?

• G09G 3/20 - Control arrangements or circuits, of interest only in connection with visual indicators other than cathode-ray tubes for presentation of an assembly of a number of characters, e.g. a page, by composing the assembly by combination of individual elements arranged in a matrix
• G06T 3/40 - Scaling of whole images or parts thereof, e.g. expanding or contracting
• H04N 5/262 - Studio circuits, e.g. for mixing, switching-over, change of character of image, other special effects
• H04N 7/01 - Conversion of standards
• H04N 21/4402 - Processing of video elementary streams, e.g. splicing a video clip retrieved from local storage with an incoming video stream or rendering scenes according to encoded video stream scene graphs involving reformatting operations of video signals for household redistribution, storage or real-time display
• H03H 17/06 - Non-recursive filters

Abstract

A method for displaying an input frame on an edge-lit display lit by a multitude of light emitting diodes (LED) placed only along one or more sides of the display, comprises the steps of determining a brightness level for each LED of the multitude of LEDs, based on the input frame and an influence of each LED on the brightness of a pixel of the display, such that the brightness of the pixel essentially corresponds to the brightness level required by the input frame and an energy consumption of the LEDs and / or a difference between a resulting backlight and the input frame is essentially minimal, according to a given measure; dimming the light emitting diodes (LED), based on at least one input frame; and displaying the input frame on the display. According to the invention, a relation between at least two different LEDs of the multitude of LEDs, in particular between their respective brightness levels, is taken into account in the determination of the brightness levels.

IPC Classes  ?

• G09G 3/34 - Control arrangements or circuits, of interest only in connection with visual indicators other than cathode-ray tubes for presentation of an assembly of a number of characters, e.g. a page, by composing the assembly by combination of individual elements arranged in a matrix by control of light from an independent source

Abstract

growing the production organism in the presence of a fermentable carbon source whereby one or more polyunsaturated fatty acids are produced, and optionally recovering the one or more polyunsaturated fatty acids.

IPC Classes  ?

• C12P 7/64 - FatsFatty oilsEster-type waxesHigher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl groupOxidised oils or fats
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C12N 9/10 - Transferases (2.)
• C12N 15/52 - Genes encoding for enzymes or proenzymes

Abstract

The invention relates to a method and an analyzing device for analyzing projection data (g) of an object (f) to be examined, said projection data being ascertained along a trajectory (φ) in multiple projection positions (λ) relative to a coordinate origin (O). A respective trajectory function is ascertained for each projection position (λ), wherein a distance (d) and a directional vector (r) relative to the coordinate origin (O) are determined for multiple positions (y) from a reconstruction region (Ω) of the dimension n; a dimension n-1 hyperplane (H), which runs perpendicular to the directional vector (r) and has the distance (d) to the coordinate origin (O), is determined; a number (s) of intersections (S) between the hyperplane (H) and the trajectory (φ) is determined; a derivation vector of the trajectory (φ) is determined according to the trajectory curve and calculated in the projection position (λ); and an absolute value of the scalar product between the derivation vector and the position (y) is determined and divided by the number (s). The ascertained trajectory functions are transformed into a frequency domain of the dimension n, and the projection data (g) is analyzed using the transformed trajectory functions.

IPC Classes  ?

• G06T 11/00 - 2D [Two Dimensional] image generation

Abstract

The invention provides novel cyclodextrin compounds. Specifically, the invention relates to cyclodextrin derivatives with thioether groups at the primary hydroxy I positions and various substituents at the secondary hydroxy I groups. The invented cyclodextrin compounds are preferably water-soluble, show high binding potential of active ingredients and do not form micelles in water. Therefore, said compounds are envisaged for complexation and eventually solubilization of a variety of active agents, including pharmaceutically active ingredients. The invention further provides a method for preparing the inventive cyclodextrin compounds as well as composition comprising the cyclodextrin compounds of the invention.

IPC Classes  ?

• C08B 37/16 - CyclodextrinDerivatives thereof

Abstract

The invention relates to methods for diagnosing Parkinson's Disease PAD) with miRNA markers. Towards the identification of biomarkers for diagnosis of PD, a comprehensive analysis of miRNA expression patterns was obtained. Significantly deregulated miRNAs were identified.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• G01N 33/567 - ImmunoassayBiospecific binding assayMaterials therefor using specific carrier or receptor proteins as ligand binding reagent utilising isolate of tissue or organ as binding agent
• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• G06F 19/20 - for hybridisation or gene expression, e.g. microarrays, sequencing by hybridisation, normalisation, profiling, noise correction models, expression ratio estimation, probe design or probe optimisation
• G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

A method for compensating Doppler shifts (v) in a mobile communication system comprises the steps of: - receiving a mobile communication signal (y); - transforming the signal in order to compensate a Doppler shift (vp) of at least one propagation path (p) of the signal (y); and - outputting the compensated signal. A matching pursuit (MP) algorithm is used for estimating Doppler shifts of propagation paths (p) of the signal.

IPC Classes  ?

• H04L 25/02 - Baseband systems Details
• H04L 25/03 - Shaping networks in transmitter or receiver, e.g. adaptive shaping networks

Abstract

A method for compensating Doppler shifts (v) in a mobile communication system comprises the steps of: receiving a mobile communication signal (y); transforming the signal in order to compensate a Doppler shift (vp) of at least one propagation path (p) of the signal (y); and outputting the compensated signal. A matching pursuit (MP) algorithm is used for estimating Doppler shifts of propagation paths (p) of the signal.

IPC Classes  ?

• H04L 27/00 - Modulated-carrier systems

Abstract

A method for displaying pixels on display devices, comprising the steps of (a) Providing virtual pixel storage means, preferably one or more virtual frame buffers (6), for temporarily storing the pixel data, (b) Receiving pixel data into the virtual pixel storage means (6) from one or more pixel sources (5), (c) Processing the pixel data stored in the virtual pixel storage means, based on characteristic display parameters characterizing the display devices; and (d) Transmitting the pixel data from the virtual pixel storage means (6) to one or more virtual displays attached to the virtual pixel storage means via a network (7), based on a network transmission protocol. The invention further relates to a system for displaying pixels on display devices.

IPC Classes  ?

• G09G 5/00 - Control arrangements or circuits for visual indicators common to cathode-ray tube indicators and other visual indicators
• G09G 5/12 - Synchronisation between the display unit and other units, e.g. other display units, video-disc players
• G06F 3/14 - Digital output to display device
• G09G 5/04 - Control arrangements or circuits for visual indicators common to cathode-ray tube indicators and other visual indicators characterised by the way in which colour is displayed using circuits for interfacing with colour displays