Abrégé

The invention relates to temperature-stable core-shell particles for the production of stimuli-responsive structural color materials. During processing, the cores self-assemble in the soft shell matrix, forming a photonic crystal. High temperature (processing) stability is achieved via optimizations of the particle architecture, regarding an optimized core proportion of 40 to 45 vol% and a reduced amount of cross-linker in the interlayer. The invention is further directed to a process for synthesizing said particles in starved-feed emulsion polymerization and to prepare a particle composition comprising the particles and at least one antioxidant. The invention further includes the use of the thereby obtained particle composition in common polymer processing techniques, especially 3D printing with the fused filament fabrication technique. The use of the invented particles and particle composition allows for preparing geometrically complex objects and detailed 3D structures with structural colors.

Classes IPC  ?

• C08F 285/00 - Composés macromoléculaires obtenus par polymérisation de monomères sur des polymères greffés préformés
• B33Y 70/00 - Matériaux spécialement adaptés à la fabrication additive
• C08K 3/04 - Carbone
• C08K 5/134 - Phénols contenant des groupes ester

Abrégé

In one aspect, the disclosure relates to compounds effective in the treatment of multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis as well as drug-sensitive tuberculosis, methods of making the same, pharmaceutical compositions comprising the same, and methods of treating bacterial infections caused by Mycobacterium tuberculosis using the same. In an aspect, the compounds and pharmaceutical compositions are not cytotoxic. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Classes IPC  ?

• C07D 401/04 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
• A61K 31/4196 - 1,2,4-Triazoles
• A61K 31/4439 - Pyridines non condenséesLeurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p. ex. oméprazole
• A61P 31/06 - Agents antibactériens pour le traitement de la tuberculose
• C07D 249/12 - Atomes d'oxygène ou de soufre
• C07D 401/14 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant au moins trois hétérocycles
• C07D 403/04 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
• C07D 405/14 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant au moins trois hétérocycles
• C07D 413/14 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle contenant au moins trois hétérocycles

Abrégé

The invention pertains to compounds and compositions comprising inhibitors of Dickkopf like protein 3 (DKK3) for use in the treatment of lung diseases, in particular of idiopathic pulmonary fibrosis (IPF). Further provided are methods for the diagnosis, stratification, and monitoring of a therapy response of such lung diseases.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• A61K 31/7088 - Composés ayant au moins trois nucléosides ou nucléotides
• A61K 38/00 - Préparations médicinales contenant des peptides
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique

Abrégé

The invention relates to a method for producing a dielectric elastomer actuator (10, 20) comprising an elastomer actuator film (1), the method comprising the following steps: • providing (S1, S2) the elastomer actuator film (1) which comprises a dielectric elastic polymer layer (2) coated on one side with a conductive electrode layer (3); • testing (S3) a dielectric strength of the elastomer film (1) by applying a test voltage in order to form a field intensity in the dielectric layer (2), which field intensity is below a breakdown field intensity of the material of the dielectric layer; • localising (S4) at least one breakdown point (46) using an optical method; • repairing (S5) the at least one localised breakdown point (46) by exclusively applying a curable adhesive (45) in addition to subsequent curing and/or by applying a repair film (44) to a side of the dielectric layer (2) opposite the electrode layer (3).

Classes IPC  ?

• H10N 30/02 - Formation d'enceintes ou d'enveloppes
• H10N 30/88 - MonturesSupportsEnveloppesBoîtiers
• H10N 30/05 - Fabrication de dispositifs piézo-électriques ou électrostrictifs multicouches ou de leurs parties constitutives, p. ex. en empilant des corps piézo-électriques et des électrodes
• H10N 30/857 - Compositions macromoléculaires

Abrégé

characterized bycharacterized by overproduction of lysine.

Classes IPC  ?

• C12P 13/00 - Préparation de composés organiques contenant de l'azote
• C12N 9/10 - Transférases (2.)
• C12N 9/06 - Oxydoréductases (1.), p. ex. luciférase agissant sur des composés contenant de l'azote comme donneurs (1.4, 1.5, 1.7)
• C12N 15/77 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes procaryotes autres que E. coli, p. ex. Lactobacillus, Micromonospora pour CorynebacteriumVecteurs ou systèmes d'expression spécialement adaptés aux hôtes procaryotes autres que E. coli, p. ex. Lactobacillus, Micromonospora pour Brevibacterium

Abrégé

The invention relates to an alloy having the following composition: NiaNi CuaCu NbbNb TabTa ZrcZr HfcHf TicTi FedFe CrdCr CodCo MndMn VeV MoeMo SnfSn AgfAg ZnfZn AlfAl SifSi GefGe SbfSb BgB CgC OhO HhH NhN Pi, with 30.00 wt.% ≤ aNi + aCu ≤ 55.00 wt.%, 35.00 wt.% ≤ bNb + bTa ≤ 68.00 wt.%, 0 wt.% ≤ cZr + cHf + cTi ≤ 12.50 wt.%, 0 wt.% ≤ dFe + dCr + dCo + dMn ≤ 8.50 wt.%, 0 wt.% ≤ eV + eMo ≤ 10.00 wt.%, 0 wt.% ≤ fSn + fAg + fZn + fAl + fSi + fGe + fSb ≤ 10.00 wt.%, 0 wt.% ≤ gB + gC ≤ 0.60 wt.%, 0 wt.% ≤ hO + hH + hN ≤ 0.10 wt.%, 0 wt.% < i ≤ 2.40 wt.%, wherein the sum of all wt.% aNi + aCu + bNb + bTa + cZr + cHf + cTi + dFe + dCr + dCo + dMn + eV + eMo + fSn + fAg + fZn + fAl + fSi + fGe + fSb + gB + gC + hO + hH + hN + i = 100 wt.% and the wt.% are each based on the total weight of the alloy, with the exception of the following alloys: Ni51,20Nb48,36P0,44, Ni51,65Nb47,47P0,88, Ni52,11Nb46,56P1,33, Ni47,58Nb50,22P2,20, Ni44,91Nb41,47Ta11,54P2,08, Ni42,52Nb33,66Ta21,85P1,97, Ni40,38Nb26,63Ta31,12P1,87, Ni36,68Nb14,51Ta47,11P1,70, Ni35,07Nb9,25Ta54,06P1,62, Ni33,59Nb4,43Ta60,42P1,56.

Classes IPC  ?

• C22C 19/03 - Alliages à base de nickel ou de cobalt, seuls ou ensemble à base de nickel
• C22C 27/02 - Alliages à base de vanadium, niobium ou tantale
• C22C 30/00 - Alliages contenant moins de 50% en poids de chaque constituant
• C22C 45/04 - Alliages amorphes avec le nickel ou le cobalt comme constituant majeur
• C22C 45/10 - Alliages amorphes avec le molybdène, le tungstène, le niobium, le tantale, le titane ou le zirconium comme constituant majeur

Abrégé

A dielectric transducer for use in a sensor, actuator or generator comprising a plurality of layers of transducer foils, wherein an electrically contactable and conductive layer forming an electrode layer is applied to at least one side of each transducer foil. Expediently, at least two contact elements are provided, each of which is arranged at least partially in a recess or in a through-channel and extends over at least one layer of transducer foils, adjacent electrode layers being electrically conductively connected to different contact elements. Since adjacent electrode layers are connected to different contact elements, intended use is possible, and bringing together several contact lines is advantageously not necessary. Furthermore, the invention relates to a method for producing a multilayer dielectric transducer for use in a sensor, an actuator or a generator, as well as an actuator, a sensor or a generator.

Classes IPC  ?

• H10N 30/87 - Électrodes ou interconnexions, p. ex. connexions électriques ou bornes
• H10N 30/057 - Fabrication de dispositifs piézo-électriques ou électrostrictifs multicouches ou de leurs parties constitutives, p. ex. en empilant des corps piézo-électriques et des électrodes par empilement de corps massifs piézo-électriques ou électrostrictifs et d’électrodes
• H10N 30/063 - Formation d’interconnexions, p. ex. d’électrodes de connexion de parties piézo-électriques ou électrostrictives multicouches
• H10N 30/50 - Dispositifs piézo-électriques ou électrostrictifs avec une structure empilée ou multicouche
• H10N 30/857 - Compositions macromoléculaires

Abrégé

The invention relates to a method for processing a separation product, containing carboxylic acids, of a separation process, in particular a process for separating fish oil and/or algae oil, in which method polyunsaturated hydrocarbons are produced at least from some of the carboxylic acids by means of microbes. Advantageously, the polyunsaturated hydrocarbons are or comprise omega-3 fatty acids and/or omega-6 fatty acids, preferably EPA, DHA and/or DPA. In an embodiment of the invention, the microbes are or comprise yeast, fungus, bacteria and/or in particular marine protists, preferably microalgae. The yeast is preferably a yeast of the Yarrowia lipolytica species and the marine protist is preferably a microalga of the Schizochytrium genus, preferably Schizochytrium limacinum SR21. The invention further relates to biomass which is produced from microbes and comprises polyunsaturated hydrocarbons.

Classes IPC  ?

• C12P 7/6432 - Acides eicosapentaénoïques
• C12P 7/6434 - Acides docosahexaénoïques
• C12P 7/6427 - Acides gras polyinsaturés, c.-à-d. ayant plusieurs liaisons doubles dans leur chaîne carbonée
• C12R 1/89 - Algues
• C12R 1/645 - Champignons

Abrégé

The invention relates to a translatory actuation unit (1, 100), comprising: - a dielectric elastomer actuator (DEA) (3, 103), which can be brought from a non-activated state to an activated state by application of an electric voltage, with a length change occurring in at least one deflection direction (A) between two connection points; - an actuation element (5, 105) for providing an actuation travel and/or an actuation force in a translatory actuation direction (S); - a linear transmission (4, 104), which connects the DEA (3, 103) to the actuation element (5, 105) with a step-down transmission ratio or a step-up transmission ratio; - a spring device, which is mechanically coupled to the DEA (3, 103) and/or to the linear transmission (4, 104), the spring device (6, 106) having an at least partially negative spring constant characteristic, so that in the activated state a deflection in the deflection direction (A) is supported with a greater force or a smaller force counteracts the deflection than in the non-activated state.

Classes IPC  ?

• H02N 2/00 - Machines électriques en général utilisant l'effet piézo-électrique, l'électrostriction ou la magnétostriction
• H02N 2/04 - Détails de structure

Abrégé

The invention relates to a system (110) comprising an input projection layer (111), at least one second digital artificial neural network (50), and at least one semiconductor chip (40) having an analogous artificial neural network (10) being mapped from a trained first digital artificial network (17) wherein the analogous electrical circuit comprises at least one input (20) being configured to receive at least one input signal and at least one output (26) being configured to provide at least one analogous output signal, wherein the analogous artificial neural network (10) electrically connects the input (20) to the output (26), wherein the semiconductor chip (40) is recursively coupled to the second digital artificial neural network (50) such that the output of the semiconductor chip (40) is provided to at least one hidden layer of the second digital artificial neural network (50) and wherein the input (20) of the semiconductor chip (40) and an input layer of the second digital artificial network (50) are electrically connected to the input projection layer (111). The invention provides a fast processing artificial neural network (10) that operates faster than the second digital artificial neural network. Thus, the analogous artificial neural network provides output to influence the operation of the second digital artificial neural network before the second digital artificial neural network provides output.

Classes IPC  ?

• G06N 3/045 - Combinaisons de réseaux
• G06N 3/063 - Réalisation physique, c.-à-d. mise en œuvre matérielle de réseaux neuronaux, de neurones ou de parties de neurone utilisant des moyens électroniques
• G06N 3/08 - Méthodes d'apprentissage

Abrégé

The present invention relates to compounds of formula (Ia) and the use thereof as inhibitors of P. aeruginosa virulence factor LasB. Formula (Ia). These compounds are useful in the treatment of bacterial infections, especially caused by P. aeruginosa. The present invention relates to compounds of formula (Ia) and the use thereof as inhibitors of P. aeruginosa virulence factor LasB. Formula (Ia). These compounds are useful in the treatment of bacterial infections, especially caused by P. aeruginosa.

Classes IPC  ?

• A61K 31/675 - Composés du phosphore ayant l'azote comme hétéro-atome d'un cycle, p. ex. phosphate de pyridoxal
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
• A61K 31/662 - Acides du phosphore ou leurs esters ayant des liaisons P-C, p. ex. foscarnet, trichlorfon
• A61K 31/428 - Thiazoles condensés avec des carbocycles
• A61K 31/426 - 1,3-Thiazoles
• A61K 31/381 - Composés hétérocycliques ayant le soufre comme hétéro-atome d'un cycle ayant des cycles à cinq chaînons
• A61K 31/4406 - Pyridines non condenséesLeurs dérivés hydrogénés substituées uniquement en position 3, p. ex. zimeldine
• A61K 31/4184 - 1,3-Diazoles condensés avec des carbocycles, p. ex. benzimidazoles

Abrégé

The invention relates to a method and a device for producing particles and to a particle dispersion.

Classes IPC  ?

• B01J 2/14 - Procédés ou dispositifs pour la granulation de substances, en généralTraitement de matériaux particulaires leur permettant de s'écouler librement, en général, p. ex. en les rendant hydrophobes sur des disques ou plateaux rotatifs
• A61K 9/50 - Microcapsules
• B01J 13/04 - Fabrication de microcapsules ou de microbilles par des procédés physiques, p. ex. séchage, pulvérisation

Abrégé

The invention relates to a device (10) for manipulating biological cells, the device (10) comprising: at least one container (22) for cultivating biological cells, the container (22) having an interior space (11), and at least one electrode (14) for manipulating the biological cells, wherein the device (10) comprises at least one separator layer (20), the at least one separator layer (20) being arranged at least between the at least one electrode (14) and the interior space (11) such that the at least one electrode (14) is arranged outside of the interior space (11). The invention further relates to a method (300) for manipulating biological cells. The invention provides a device (10) and a method (300) for manipulating biological cells that avoids the degradation of the cells in containers (22) during the manipulation of the cells with electric fields.

Classes IPC  ?

• C12M 1/32 - Inoculateur ou échantillonneur du type à champs multiples ou en continu
• C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
• C12M 1/26 - Inoculateur ou échantillonneur
• C12M 1/42 - Appareils pour le traitement de micro-organismes ou d'enzymes au moyen d'énergie électrique ou ondulatoire, p. ex. magnétisme, ondes sonores

Abrégé

Mycobacterium tuberculosisMycobacterium tuberculosis using the same. In an aspect, the compounds and pharmaceutical compositions are not cytotoxic. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Classes IPC  ?

• A61K 31/4196 - 1,2,4-Triazoles
• A61K 31/395 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines
• A61K 31/422 - Oxazoles non condensés et contenant d'autres hétérocycles
• A61K 31/33 - Composés hétérocycliques

Abrégé

The present invention relates to a composition suitable for use as an electrolyte in a battery, comprising (i) at least one ionic liquid comprising an organic cation and (ii) at least one redox active organic compound, wherein the composition is free of solvent.

Classes IPC  ?

• H01M 8/18 - Éléments à combustible à régénération, p. ex. batteries à flux REDOX ou éléments à combustible secondaires

Abrégé

A process of structuring a diamond substrate, comprising the steps of (a) depositing an adhesion layer on a face of the diamond substrate; (b) coating a resist layer on the adhesion layer; (c) removing parts of the resist layer so as to expose parts of the adhesion layer and form a corresponding structuring mask; (d) etching the adhesion layer and the diamond substrate (2) through the structuring mask so as to structure the diamond substrate; wherein the adhesion layer is a non-metallic compound comprising oxides.

Classes IPC  ?

• G03F 7/11 - Matériaux photosensibles caractérisés par des détails de structure, p. ex. supports, couches auxiliaires avec des couches de recouvrement ou des couches intermédiaires, p. ex. couches d'ancrage
• C30B 33/12 - Gravure dans une atmosphère gazeuse ou un plasma
• C30B 29/04 - Diamant
• G03F 7/075 - Composés contenant du silicium
• G03F 7/00 - Production par voie photomécanique, p. ex. photolithographique, de surfaces texturées, p. ex. surfaces impriméesMatériaux à cet effet, p. ex. comportant des photoréservesAppareillages spécialement adaptés à cet effet

Abrégé

The present invention relates to the production of bacteriocins, and in particular the production of bacteriocins of class I or II by recombinant expression in coryneform bacteria as the bacterial cell host. Also provided are modified coryneform bacteria for use as production hosts for production of bacteriocins.

Classes IPC  ?

• A61P 31/04 - Agents antibactériens
• A61K 35/74 - Bactéries
• C12N 1/00 - Micro-organismes, p. ex. protozoairesCompositions les contenantProcédés de culture ou de conservation de micro-organismes, ou de compositions les contenantProcédés de préparation ou d'isolement d'une composition contenant un micro-organismeLeurs milieux de culture

Abrégé

Provided are methods in a system of at least a second and a third artificial intelligence unit, comprising: inputting first input values to at least one second artificial intelligence unit, and obtaining output values based on the input values from the at least one second artificial intelligence unit; at least temporarily storing situation data, the situation data comprising first input values and/or second output values of the at least one second unit; using the situation data as input values of the third artificial intelligence unit, the third artificial intelligence unit generating third output values in response to the input values; and checking whether the second output values of the at least one second unit satisfy one or more predetermined conditions based on the third output values. Also provided is a system for carrying out such a method.

Classes IPC  ?

• G06N 3/04 - Architecture, p. ex. topologie d'interconnexion
• G06N 3/08 - Méthodes d'apprentissage

Abrégé

Provided is a method in a system of at least two artificial intelligence units, comprising inputting input values to at least a first artificial intelligence unit and a second artificial intelligence unit; obtaining first output values of the first artificial intelligence unit; forming one or more modulation functions based on the output values of the first artificial intelligence unit; applying the formed one or more modulation functions to one or more parameters of the second artificial intelligence unit, the one or more parameters influencing the processing of input values and the obtaining of output values in the second artificial intelligence unit; and finally obtaining second output values of the second artificial intelligence unit.

Classes IPC  ?

• G06N 3/04 - Architecture, p. ex. topologie d'interconnexion
• G06N 3/08 - Méthodes d'apprentissage

Abrégé

The present invention provides a method for detecting structural variations (SV) within genomes of single cells or population of single cells by integrating a three-layered information of sequencing read depth, read strand orientation and haplotype phase. The method of the invention can detect deletions, duplications, polyploidies, translocations, inversions, and copy number neutral loss of heterozygosity (CNN-LOH), and more. The method of the invention can fully karyotype a genome comprehensively, and may be applied in research and clinical approaches. For example, the methods of the invention are useful for analysing cellular samples of patients for diagnosing or aiding a diagnosis, in reproductive medicine to detect embryonic abnormalities, or during therapeutic approaches based on cellular therapies to quality control genetically engineered cells, such as in adoptive T cell therapy and others. The method of the invention may further be applied in research to decipher the karyotypes of cellular models (cell lines), patient samples, or to further unravel genetic and mechanistic pathways leading to the generation of any SV within genomes.

Classes IPC  ?

• G16B 20/20 - Détection d’allèles ou de variantes, p. ex. détection de polymorphisme d’un seul nucléotide
• G16B 30/00 - TIC spécialement adaptées à l’analyse de séquences impliquant des nucléotides ou des aminoacides
• G16B 50/00 - TIC pour la programmation d’outils ou de systèmes de bases de données spécialement adaptées à la bio-informatique

Abrégé

Disclosed are Synovial Sarcoma X breakpoint 2 binding molecules and methods for their use in the detection and treatment of cancer.

Classes IPC  ?

• C07K 16/30 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire provenant de cellules de tumeurs
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères

Abrégé

A method for processing search queries directed at a database containing medical sample data and/or samples from a plurality of samples of persons comprises the steps of entering a search query with a request profile directed at retrieving at least one sample with sample data that has predetermined queried search parameters into an AI processor device, searching for at least one selected sample using the AI processor device, the at least one selected sample satisfying the request profile at least with a given probability, and outputting identification data for the at least one selected sample. A search platform device configured to process search queries directed at a database containing medical sample data and/or samples from a plurality of samples of persons is also described.

Classes IPC  ?

• G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p. ex. pour des analyses d’échantillon de patient
• G06F 17/00 - Équipement ou méthodes de traitement de données ou de calcul numérique, spécialement adaptés à des fonctions spécifiques
• G16H 40/20 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion ou l’administration de ressources ou d’établissements de soins de santé, p. ex. pour la gestion du personnel hospitalier ou de salles d’opération

Abrégé

An avatar apparatus that is designed to represent a person and to process person-related data of the person comprises an AI processor device designed for machine-learning of individual mental reaction features of the person by means of a data training, wherein the AI processor device is configured to react to questions by generating semantic responses on the basis of the mental reaction features, a first storage device that is coupled to the AI processor device and arranged to store the mental reaction features of the person, an input device that is coupled to the AI processor device and designed to interact with the person and/or to receive questions relating to the person, and an output device that is designed to output signals that represent the responses generated by the AI processor device. An avatar system having multiple avatar apparatuses, applications of the avatar apparatus and an avatar method for operating an avatar apparatus are also described.

Classes IPC  ?

• G06Q 50/00 - Technologies de l’information et de la communication [TIC] spécialement adaptées à la mise en œuvre des procédés d’affaires d’un secteur particulier d’activité économique, p. ex. aux services d’utilité publique ou au tourisme

Abrégé

The invention relates to a method implemented in a controller of a machine for processing input values in an overall system having a working level and a rating level, comprising inputting first input values to the working level and determining first output values; forming first situation data; inputting the first situation data to the rating level and determining first ratings that indicate whether the first situation data meet predefined first conditions; influencing the determination of the first output values based on the first ratings; inputting second input values to the working level and determining second output values, wherein the determination of the second output values is influenced by the first output values; forming second situation data; inputting the second situation data to the rating level and determining second ratings that indicate whether the second situation data meet predefined second conditions, wherein the determination of the second ratings is influenced by the first ratings; influencing the determination of the second output values based on the second ratings; wherein the first and/or the second output values are used as overall output values of the overall system.

Classes IPC  ?

• G05B 19/042 - Commande à programme autre que la commande numérique, c.-à-d. dans des automatismes à séquence ou dans des automates à logique utilisant des processeurs numériques
• B60W 30/00 - Fonctions des systèmes d'aide à la conduite des véhicules routiers non liées à la commande d'un sous-ensemble particulier, p. ex. de systèmes comportant la commande conjuguée de plusieurs sous-ensembles du véhicule
• G05B 13/02 - Systèmes de commande adaptatifs, c.-à-d. systèmes se réglant eux-mêmes automatiquement pour obtenir un rendement optimal suivant un critère prédéterminé électriques
• G06N 3/04 - Architecture, p. ex. topologie d'interconnexion
• G06Q 50/04 - Fabrication

Abrégé

b) are provided for movement into the working position. With the at least two restoring means, a total restoring means characteristic curve, which is composed of portions of the individual, preferably preloaded restoring means as well as a portion of a variable stiffness of the actuator element, can be advantageously tailored.

Classes IPC  ?

• F03G 7/06 - Mécanismes produisant une puissance mécanique, non prévus ailleurs ou utilisant une source d'énergie non prévue ailleurs utilisant la dilatation ou la contraction des corps produites par le chauffage, le refroidissement, l'humidification, le séchage ou par des phénomènes similaires
• F16D 121/18 - Électrique ou magnétique
• F16K 31/02 - Moyens de fonctionnementDispositifs de retour à la position de repos électriquesMoyens de fonctionnementDispositifs de retour à la position de repos magnétiques

Abrégé

A sample collection kit (100) for collecting plant samples, in particular algae samples for biomedical applications, comprises at least one sample receptacle (10) designed to receive plant samples, a sensor arrangement (20) having multiple sensors that can be used to capture sample data, a data recording device (30) designed to record the sample data, a tool arrangement (40, 50) having collection tools, which are designed for harvesting the plant samples, and having processing tools, which are designed for processing the plant samples, a receptacle device (70) designed to receive the tool arrangement and the device arrangement in a state that is isolated from the surroundings, and identification markings (80) that contain identification data and are attached to the at least one sample receptacle, the collection tools and the processing tools, wherein there is provision for an authentication device (90) that contains an electronically readable data carrier containing authentication data that represent a state of the sample collection kit (100), and the authentication device (90) is attached to at least one from the receptacle device (70), the at least one sample container, the collection tools and the processing tools. An authentication arrangement (300) and a method for checking a state of a sample collection kit are also described.

Classes IPC  ?

• H04L 9/40 - Protocoles réseaux de sécurité
• B01L 1/00 - EnceintesChambres
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes

Abrégé

The present invention relates to compounds of formula (la) and the use thereof as inhibitors of P. aeruginosa virulence factor LasB. Formula (la). These compounds are useful in the treatment of bacterial infections, especially caused by P. aeruginosa.

Classes IPC  ?

• C07C 323/60 - Thiols, sulfures, hydropolysulfures ou polysulfures substitués par des halogènes, des atomes d'oxygène ou d'azote ou par des atomes de soufre ne faisant pas partie de groupes thio contenant des groupes thio et des groupes carboxyle liés au même squelette carboné ayant les atomes de soufre des groupes thio liés à des atomes de carbone acycliques du squelette carboné avec l'atome de carbone d'au moins un des groupes carboxyle lié à des atomes d'azote
• C07D 213/74 - Radicaux amino ou imino substitués par des radicaux hydrocarbonés ou par des radicaux hydrocarbonés substitués
• C07D 277/82 - Atomes d'azote
• C07D 333/36 - Atomes d'azote
• C07F 9/38 - Acides phosphoniques [R—P(:O)(OH)2]Acides thiophosphoniques
• C07F 9/40 - Leurs esters
• A61K 31/095 - Composés du soufre, du sélénium ou du tellure, p. ex. thiols
• A61K 31/10 - SulfuresSulfoxydesSulfones
• A61K 31/167 - Amides, p. ex. acides hydroxamiques ayant des cycles aromatiques, p. ex. colchicine, aténolol, progabide ayant l'atome d'azote d'un groupe carboxamide lié directement au cycle aromatique, p. ex. lidocaïne, paracétamol
• A61K 31/426 - 1,3-Thiazoles
• A61K 31/428 - Thiazoles condensés avec des carbocycles
• A61K 31/4406 - Pyridines non condenséesLeurs dérivés hydrogénés substituées uniquement en position 3, p. ex. zimeldine
• A61K 31/4184 - 1,3-Diazoles condensés avec des carbocycles, p. ex. benzimidazoles
• A61P 31/04 - Agents antibactériens
• C07D 235/30 - Atomes d'azote ne faisant pas partie d'un radical nitro
• C07D 277/46 - Radicaux amino ou imino acylés par les acides carboxyliques ou par leurs analogues du soufre ou de l'azote

Abrégé

The invention relates to a method for producing microparticles, having the steps of: A) producing a solution of a surfactant in a polar solvent, B) adding a meltable precursor of a polysiloxane-glass hybrid in order to produce a mixture of the meltable precursor and the surfactant solution, C) heating the mixture above the melting temperature of the meltable precursor in order to produce an emulsion from droplets of the meltable precursor, and D) adding a catalyst in order to initiate a crosslinking reaction on the surface of the droplets, thereby producing microparticles. The invention additionally relates to unconsolidated and consolidated microparticles which can be produced using the method, to the use of the microparticles, and to a component comprising a conversion layer comprising the microparticles.

Classes IPC  ?

• B01J 13/14 - Polymérisation, réticulation
• A61K 9/50 - Microcapsules
• C09B 67/02 - Préparations tinctoriales caractérisées par un aspect physique particulier, p. ex. tablettes, feuilles
• C11D 3/50 - Parfums

Abrégé

The present invention relates to a method for determining a cancer therapy based on at least one antibody drug, comprising: a) determining at least one parameter selected from the absolute number of at least one receptor per cell, the mean receptor density of at least one receptor per cell, the cumulative frequency of mean receptor densities of at least one receptor per cell, the average receptor density of at least one receptor of cells of a subject and cumulative or statistical distributions thereof, b) determining the at least one antibody drug and/or a personalized dosage of the at least one antibody drug for the subject on the basis of the parameter/parameters determined in a).

Classes IPC  ?

• G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
• G01N 33/563 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet faisant intervenir des fragments d'anticorps
• G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
• H01J 37/22 - Dispositifs optiques ou photographiques associés au tube

Abrégé

The invention relates to a method for producing a thermoelastic arrangement for an energy converter, wherein thermoelastic strand elements (6) with a constant elongation are fixed between at least two retaining elements (7, 7a, 7b) in order to obtain a bundle of strand elements (6) extending in the longitudinal direction and having identical pre-elongation.

Classes IPC  ?

• F03G 7/06 - Mécanismes produisant une puissance mécanique, non prévus ailleurs ou utilisant une source d'énergie non prévue ailleurs utilisant la dilatation ou la contraction des corps produites par le chauffage, le refroidissement, l'humidification, le séchage ou par des phénomènes similaires

Abrégé

A composition precursor including a three-dimensional network consisting of partially cross-linked monomer units and an alkoxy-terminated oligo- or polysiloxane, wherein the monomer units comprise at least one trialkoxysilane and at least one dialkoxysilane. Also disclosed are a composition, a method for producing a composition precursor and a composition, use of a composition and a component.

Classes IPC  ?

• C08G 77/06 - Procédés de préparation
• C08L 83/04 - Polysiloxanes
• H01L 33/56 - Matériaux, p.ex. résine époxy ou silicone

Abrégé

t).

Classes IPC  ?

• G01N 1/40 - Concentration des échantillons
• G01N 33/00 - Recherche ou analyse des matériaux par des méthodes spécifiques non couvertes par les groupes

Abrégé

The invention relates to a device for removing a gas from an aqueous liquid, in particular a blood liquid, said device having: a first compartment, through which the aqueous liquid flows during operation of the device; a second compartment, through which a purge gas flows during operation of the device, the first compartment and the second compartment being separated from one another by a semi-permeable membrane; and a third compartment, through which a liquid proton donor which is an organic or inorganic acid flows during operation of the device, the first compartment and the third compartment being separated from one another by a membrane that is permeable to ions, the membrane that is permeable to ions having at least one cation conductor.

Classes IPC  ?

• B01D 63/02 - Modules à fibres creuses
• A61M 1/16 - Systèmes de dialyseReins artificielsOxygénateurs du sang avec membranes
• A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p. ex. adaptation de la température, irradiation
• B01D 63/04 - Modules à fibres creuses comprenant plusieurs ensembles à fibres creuses
• B01D 71/26 - Polyalcènes
• B01D 71/36 - Polytétrafluoro-éthylène

Abrégé

The invention relates to a device for the improved induction of noise by means of electromagnetic radiation, comprising: a substrate layer; a first substance, which has a reflective property with respect to electromagnetic radiation of a predetermined wavelength spectrum; and a second substance, which has an absorbing property with respect to electromagnetic radiation of the predetermined wavelength spectrum; the first substance being located in a region between the substrate layer and the second substance. A corresponding method is also provided.

Classes IPC  ?

• A61N 5/06 - Thérapie par radiations utilisant un rayonnement lumineux
• H04R 25/00 - Appareils pour sourds

Abrégé

The invention relates to a method for operating a gas sensor system (1) having a gas sensor (3) with an active sensor surface (31) in a diagnostic mode and in a measurement mode, the following steps being carried out in the diagnostic mode: - operating (S7) the gas sensor (3) in a high-temperature phase, said high-temperature phase taking place at a temperature at which bonding of oxygen ions to points on the surface of the active sensor surface (31) is effected; - detecting (S8) a change to an electrical measurement variable, in particular electrical conductivity, of the gas sensor (3) occurring during the high-temperature phase, which change specifies an oxidation rate of an enrichment of the active sensor surface (31) with oxygen ions; - determining (S9) a degradation of the gas sensor (3) according to the profile or the change to the electrical measurement variable of the gas sensor (3); the gas sensor system (1) being operated in the measurement mode depending on the degradation.

Classes IPC  ?

• G01N 27/12 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance en recherchant la résistance d'un corps solide dépendant de l'absorption d'un fluideRecherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance en recherchant la résistance d'un corps solide dépendant de la réaction avec un fluide
• G01N 33/00 - Recherche ou analyse des matériaux par des méthodes spécifiques non couvertes par les groupes

Abrégé

The invention relates to a dielectric transducer (1; 1a; 1b) for use in a sensor, actuator or generator, comprising multiple layers of transducer foils (2, 3, 4; 2a, 3a, 4a; 2b, 3b, 4b, 20), wherein an electrically contactable and conductive layer forming an electrode layer (6, 7; 6a, 7a; 6b, 7b, 20) is applied to at least one side of each transducer foil (2, 3, 4; 2a, 3a, 4a; 2b, 3b, 4b, 20). According to the intended use, at least two contact elements (11, 12; 11a; 11b) are provided, each of which is arranged at least partially in a recess (9, 10; 9a) or in a through channel and extends over at least one layer of transducer foils (2, 3, 4; 2a, 3a, 4a; 2b, 3b, 4b, 20), wherein neighbouring electrode layers (6, 7; 6a, 7a; 6b, 7b, 20) are electrically conductively connected to different contact elements (11, 12; 11a; 11b). Given that neighbouring electrode layers are connected to different contact elements, the intended use is possible and a joining of multiple contact lines is advantageously not required. The invention also relates to a method for producing a multi-layer dielectric transducer for use in a sensor, an actuator or a generator, as well as an actuator, a sensor or a generator.

Classes IPC  ?

• H01L 41/047 - Electrodes
• H01L 41/083 - Eléments piézo-électriques ou électrostrictifs avec une structure empilée ou multicouche
• H01L 41/193 - Compositions macromoléculaires
• H01L 41/27 - Fabrication de dispositifs piézo-électriques ou électrostrictifs multicouches ou de leurs parties constitutives, p.ex. en empilant des corps piézo-électriques et des électrodes
• H01L 41/293 - Formation d’électrodes, de connexions électriques ou de dispositions de bornes Électrodes de connexion de parties piézo-électriques ou électrostrictives multicouches

Abrégé

The invention relates to a device (1) for determining a pressure acting on a surface (2) or a wall of a body (4) arranged in a flow channel (3-3b) or a change of pressure over time acting on a surface (2) or a wall of a body (4) arranged in a flow channel (3-3b), which device comprises at least one means for detecting the pressure or the change of pressure over time, the detection means having a sensor chip (5-5b) with at least one sensor (6-6b). The sensor chip (5-5b) is expediently provided in order to form a wall portion of the body (4). Advantageously the body itself does not have to be changed in order to detect a pressure acting on the surface or the wall or a change of pressure in the flow channel acting on the surface or the wall. A change to the body which influences the flow conditions, in particular in the boundary layer, is advantageously prevented. Furthermore, the invention relates to a method for producing a sensor chip (6-6b) and to a sensor chip (6-6b).

Classes IPC  ?

• G01L 9/00 - Mesure de la pression permanente, ou quasi permanente d’un fluide ou d’un matériau solide fluent par des éléments électriques ou magnétiques sensibles à la pressionTransmission ou indication par des moyens électriques ou magnétiques du déplacement des éléments mécaniques sensibles à la pression, utilisés pour mesurer la pression permanente ou quasi permanente d’un fluide ou d’un matériau solide fluent
• G01L 27/00 - Test ou étalonnage des appareils pour la mesure de la pression des fluides
• G01M 9/06 - Dispositions pour la mesure spécialement adaptées aux tests aérodynamiques

Abrégé

The invention relates to a thermal actuator arrangement (1) for moving an actuator (4) between a first actuating position (S1) and a second actuating position (S2), comprising: - a first partial actuator (2) having a first thermal actuator element (21), to which a first opposing force (F1) is applied; - a second partial actuator (3) having a second thermal actuator element (31), to which a second opposing force (F2) is applied, wherein the actuator elements (21, 31) are designed to modify their shape against the opposing force (F1, F2) in each case as a result of a temperature modification; - an actuator (4), which is coupled to the first partial actuator (2) such that, when the first actuator element (21) is deactivated, the actuator (4) is held in the first actuating position (S1) when a holding force takes effect and, when the holding force (H) is eliminated, the actuator (4) moves to the second actuating position (S2) due to the effect of the first opposing force (F1); - a safety element (5), which is coupled to the second partial actuator in order to provide the holding force (H) when the second actuator element (31) is in the deactivated state and to reduce or eliminate the holding force (H) when the second actuator element (31) is in the activated state.

Classes IPC  ?

• F03G 7/06 - Mécanismes produisant une puissance mécanique, non prévus ailleurs ou utilisant une source d'énergie non prévue ailleurs utilisant la dilatation ou la contraction des corps produites par le chauffage, le refroidissement, l'humidification, le séchage ou par des phénomènes similaires

Abrégé

The invention is directed to a process of structuring a diamond substrate (2), comprising the steps of (a) depositing an adhesion layer (14) on a face of the diamond substrate (2); (b) coating a resist layer (16) on the adhesion layer (14); (c) removing parts of the resist layer (16) so as to expose parts of the adhesion layer and form a corresponding structuring mask (24); (d) etching the adhesion layer (14) and the diamond substrate (2) through the structuring mask (24) so as to structure (28) said diamond substrate (2); wherein the adhesion layer (14) is a non-metallic compound comprising oxides.

Classes IPC  ?

• C30B 29/04 - Diamant
• C30B 33/12 - Gravure dans une atmosphère gazeuse ou un plasma
• G03F 7/00 - Production par voie photomécanique, p. ex. photolithographique, de surfaces texturées, p. ex. surfaces impriméesMatériaux à cet effet, p. ex. comportant des photoréservesAppareillages spécialement adaptés à cet effet
• G03F 7/075 - Composés contenant du silicium
• G03F 7/11 - Matériaux photosensibles caractérisés par des détails de structure, p. ex. supports, couches auxiliaires avec des couches de recouvrement ou des couches intermédiaires, p. ex. couches d'ancrage
• G03F 7/16 - Procédés de couchageAppareillages à cet effet
• G03F 7/40 - Traitement après le dépouillement selon l'image, p. ex. émaillage

Produits et services

Scientific instruments; Computer programs for the recording and management of medical data; Software for producing study protocols, in particular study protocols for clinical trials; Software for creating standardised procedural processes, in particular standard operation procedures for clinical trials; Software for creating electronic protocols for use in clinical trials, in particular creating so-called case report forms; Computer programs for processing image data, in particular medical image data; Computer programs for processing image data by means of artificial intelligence. Data management services. Data transmission via computer networks; Providing of access to a computer network and electronic exchange of data in a computer network, in particular access to a computer program for the recording and management of medical data. Organising and arranging of training courses for the use of computer programs; Arranging of training for planning, creating, and conducting clinical trials and for good clinical practice (GCP). Electronic data storage and data back-up services, In particular storage and security of clinical trial results; Computer software for the statistical evaluation of data, in particular data from clinical trials; Experiment planning for clinical trials, in particular computerised or computer-assisted; Scientific services relating to planning, creating and conducting clinical trials, in particular for collecting or processing data for conducting clinical trials; Installation, updating, maintenance and care of computer software; Design and development of data management software; Design services for computer programs; Rental of computers and computer software for data processing; Providing electronic memory space on the Internet; Management of databases, in particular of the aforesaid, containing medical data; Scientific services relating to creating case report forms; Scientific consultancy relating to the design of clinical trials; Technical consultancy relating to the operation of software, in particular personal, by means of telephone or video chat; Processing the time process plan for clinical trials; Technical consultancy relating to data management for the non-medical sector; Graphic illustration services for others, In particular graphic presentations of the process of clinical trials.

Produits et services

Scientific instruments; Computer programs for the recording and management of medical data; Software for producing study protocols, in particular study protocols for clinical trials; Software for creating standardised procedural processes, in particular standard operation procedures for clinical trials; Software for creating electronic protocols for use in clinical trials, in particular creating so-called case report forms; Computer programs for processing image data, in particular medical image data; Computer programs for processing image data by means of artificial intelligence. Data management services. Data transfer via a computer network; Providing of access to a computer network and electronic exchange of data in a computer network, in particular access to a computer program for the recording and management of medical data. Organising and arranging of training courses for the use of computer programs; Arranging of training for planning, creating, and conducting clinical trials and for good clinical practice (GCP). Electronic data storage and data back-up services, In particular storage and security of clinical trial results; Computer software for the statistical evaluation of data, in particular data from clinical trials; Experiment planning for clinical trials, in particular computerised or computer-assisted; Scientific services relating to planning, creating and conducting clinical trials, in particular for collecting or processing data for conducting clinical trials; Installation, updating, maintenance and care of computer software; Design and development of data management software; Design services for computer programs; Rental of computers and computer software for data processing; Providing electronic memory space on the Internet; Management of databases, in particular of the aforesaid, containing medical data; Scientific services relating to creating case report forms; Scientific consultancy relating to the design of clinical trials; Technical consultancy relating to the operation of software, in particular personal, by means of telephone or video chat; Processing the time process plan for clinical trials; Technical consultancy relating to data management for the non-medical sector; Graphic illustration services for others, In particular graphic presentations of the process of clinical trials.

Abrégé

The present invention relates to an active substance delivery system, preferably an anti- cancer agent delivery system, comprising one or more active substances included in nanoparticles and a method for producing such a delivery system.

Classes IPC  ?

• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 9/51 - Nanocapsules
• A61K 47/34 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyesters, acides polyaminés, polysiloxanes, polyphosphazines, copolymères de polyalkylène glycol ou de poloxamères

Abrégé

The invention relates to a method in a system formed by at least two artificial learning units, comprising: inputting input values at at least one first artificial learning unit and a second artificial learning unit; obtaining first output values from the first artificial learning unit; forming one or more modulation functions on the basis of the output values of the first artificial learning unit; applying the formed one or more modulation functions to one or more parameters of the second artificial learning unit, wherein the one or more parameters influence the processing of input values and the obtaining of output values in the second artificial learning unit; and finally, obtaining second output values from the second artificial learning unit.

Classes IPC  ?

• G06N 3/04 - Architecture, p. ex. topologie d'interconnexion
• G06N 3/08 - Méthodes d'apprentissage

Abrégé

The invention relates to a method in a system consisting of at least one second and a third artificially learning unit, having the steps of: inputting first input values on at least one second artificially learning unit and obtaining output values based on the input values from the at least one second artificially learning unit; at least temporarily storing situation data, said situation data comprising first input values and/or second output values of the at least one second unit; using the situation data as input values for the third artificially learning unit, said third artificially learning unit generating third output values in response to the input values; and checking whether the second output values of the at least one second unit satisfy one or more specified conditions on the basis of the third output values. The invention additionally relates to a system for carrying out such a method.

Classes IPC  ?

• G06N 3/04 - Architecture, p. ex. topologie d'interconnexion
• G06N 3/08 - Méthodes d'apprentissage

Abrégé

The invention relates to a thermoelastic energy converter (1), in particular for use in a thermoelastic heating/cooling apparatus or in a combined heat-and-power coupling system, comprising: - an arrangement comprising a plurality of converter devices (3a, 3b), wherein each of the converter devices (3a, 3b) has one or more thermoelastic elements (4) arranged in a direction of extension; - a loading device, in order to load the thermoelastic elements (4) of each of the plurality of converter devices (3a, 3b) so as to have a temporally variable power curve; - a coupling which is designed such that the loading device actuates the converter devices (3a, 3b) in a phase-offset manner with respect to their cyclic loading and unloading.

Classes IPC  ?

• F03G 7/06 - Mécanismes produisant une puissance mécanique, non prévus ailleurs ou utilisant une source d'énergie non prévue ailleurs utilisant la dilatation ou la contraction des corps produites par le chauffage, le refroidissement, l'humidification, le séchage ou par des phénomènes similaires
• F25B 21/00 - Machines, installations ou systèmes utilisant des effets électriques ou magnétiques
• F25B 23/00 - Machines, installations ou systèmes ayant un seul principe de fonctionnement non compris dans les groupes , p. ex. utilisant l'effet de radiation sélective

Abrégé

8, n are as defined in the claims and in the description. The present invention also relates to a polymer comprising in copolymerized form at least one compound of formula (I) and an organopolysiloxane and to novel compounds of formula (I).

Classes IPC  ?

• C08G 77/442 - Polymères séquencés ou greffés contenant des segments de polysiloxanes contenant des segments de polymères vinyliques
• C07D 471/06 - Systèmes condensés en péri
• C09B 69/10 - Colorants polymèresProduits de réactions de colorants avec des monomères ou avec des composés macromoléculaires
• C09K 11/06 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances organiques luminescentes
• H01L 33/50 - DISPOSITIFS À SEMI-CONDUCTEURS NON COUVERTS PAR LA CLASSE - Détails caractérisés par les éléments du boîtier des corps semi-conducteurs Éléments de conversion de la longueur d'onde

Abrégé

A computer-implemented method for processing a database transaction in a network of database nodes, comprising the steps: Receiving, at a first database node, instructions specifying a database transaction from a database client; determining an effect of the received instructions; among all nodes, forming a consensus on the determined effect.

Classes IPC  ?

• G06F 21/64 - Protection de l’intégrité des données, p. ex. par sommes de contrôle, certificats ou signatures
• G06F 16/27 - Réplication, distribution ou synchronisation de données entre bases de données ou dans un système de bases de données distribuéesArchitectures de systèmes de bases de données distribuées à cet effet
• H04L 9/32 - Dispositions pour les communications secrètes ou protégéesProtocoles réseaux de sécurité comprenant des moyens pour vérifier l'identité ou l'autorisation d'un utilisateur du système

Abrégé

[1] The present invention provides a method for detecting structural variations (SV) within genomes of single cells or population of single cells by integrating a three-layered information of sequencing read depth, read strand orientation and haplotype phase. The method of the invention can detect deletions, duplications, polyploidies, translocations, inversions, and copy number neutral loss of heterozygosity (CNN-LOH), and more. The method of the invention can fully karyotype a genome comprehensively, and may be applied in research and clinical approaches. For example, the methods of the invention are useful for analysing cellular samples of patients for diagnosing or aiding a diagnosis, in reproductive medicine to detect embryonic abnormalities, or during therapeutic approaches based on cellular therapies to quality control genetically engineered cells, such as in adoptive T cell therapy and others. The method of the invention may further be applied in research to decipher the karyotypes of cellular models (cell lines), patient samples, or to further unravel genetic and mechanistic pathways leading to the generation of any SV within genomes.

Classes IPC  ?

• G16B 20/20 - Détection d’allèles ou de variantes, p. ex. détection de polymorphisme d’un seul nucléotide
• G16B 30/10 - Alignement de séquenceRecherche d’homologie
• G16B 50/10 - OntologiesAnnotations

Abrégé

The invention relates to an actuator (1), which can be moved from a starting position into a working position, and which has at least one actuator element (2) that can be changed with respect to its dimensions by way of an electrical signal, and in particular is made of a dielectric elastomer or a shape-memory alloy. At least two restoring means (20, 30) acting on the actuator element are provided for the movement into the working position, in particular a non-linear snap spring (20) and a linear helical spring (30). By way of the restoring means, a total restoring means characteristic curve, which is composed of portions of the individual, preferably prestressed restoring means and a portion of variable rigidity of the actuator element, can be advantageously tailored.

Classes IPC  ?

• H01L 41/09 - Eléments piézo-électriques ou électrostrictifs à entrée électrique et sortie mécanique
• H01L 41/053 - Montures, supports, enveloppes ou boîtiers
• F03G 7/06 - Mécanismes produisant une puissance mécanique, non prévus ailleurs ou utilisant une source d'énergie non prévue ailleurs utilisant la dilatation ou la contraction des corps produites par le chauffage, le refroidissement, l'humidification, le séchage ou par des phénomènes similaires

Abrégé

A sulfurous, metallic glass forming alloy and a method for the production thereof are described.

Classes IPC  ?

• C22C 45/10 - Alliages amorphes avec le molybdène, le tungstène, le niobium, le tantale, le titane ou le zirconium comme constituant majeur
• C22C 45/00 - Alliages amorphes
• C22C 1/00 - Fabrication des alliages non ferreux

Abrégé

The present invention relates to methods for diagnosing a Parkinson's syndrome (PS), Parkinson's disease (PD), or Parkinsonism in an individual. Further, the present invention relates to a method for differential diagnosing between PD and Parkinsonism. Furthermore, the present invention relates to methods for monitoring the course of a Parkinson's syndrome, Parkinson's disease (PD), or Parkinsonism in an individual. In addition, the present invention relates to kits suitable to carry out the above described methods.

Classes IPC  ?

• C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
• G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet

Abrégé

The present invention relates to a method of monitoring or determining the fitness level of a subject. The present invention further relates to a method of determining the training mode of a subject. The present invention also relates to a method of optimizing personal training of a subject. In addition, the present invention relates to a kit for carrying out the above-described methods.

Classes IPC  ?

• C12Q 1/6876 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes
• C12Q 1/6881 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour le typage de tissu ou de cellule, p. ex. sondes d’antigène leucocytaire humain [HLA]

Abrégé

144, X, n, p, q, r and s are defined in the description.

Classes IPC  ?

• C07C 391/00 - Composés contenant du sélenium
• A61K 31/095 - Composés du soufre, du sélénium ou du tellure, p. ex. thiols
• A61K 31/12 - Cétones
• A61K 31/277 - NitrilesIsonitriles ayant un cycle, p. ex. vérapamil
• A61P 31/04 - Agents antibactériens
• A61P 35/00 - Agents anticancéreux

Abrégé

The invention relates to a modular cannula device in various embodiments, which cannula device comprises an external tubular cannula, a first tubular guide part, which has a narrowing distal end and can be inserted into the cannula such that the outer wall of the first guide part lies tightly against the inner wall of the cannula, and a second tubular guide part, which has a narrowing, tapered distal end and can be inserted into the first guide part such that the outer wall of the second guide part lies tightly against the inner wall of the first guide part.

Classes IPC  ?

• A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p. ex. adaptation de la température, irradiation
• A61M 1/16 - Systèmes de dialyseReins artificielsOxygénateurs du sang avec membranes
• A61M 25/00 - CathétersSondes creuses

Abrégé

The invention relates to a composition precursor comprising a three-dimensional network consisting of partially cross-linked monomer units and an alkoxy-terminated oligo- or polysiloxane, wherein the monomer units comprise at least one trialkoxysilane and at least one dialkoxysilane. The invention further relates to a composition, to a method for producing a composition precursor and to a composition, to a use of a composition and to a component.

Classes IPC  ?

• C08G 77/04 - Polysiloxanes
• C08G 77/06 - Procédés de préparation
• C08L 83/04 - Polysiloxanes
• H01L 23/29 - Encapsulations, p. ex. couches d’encapsulation, revêtements caractérisées par le matériau

Abrégé

The invention relates to a conversion element (100) for an optoelectronic component (1000), comprising at least one conversion material (1) that is designed for wavelength conversion, a polymer matrix material (2) produced by condensation reaction of trialkoxysilane- and dialkoxysilane monomer units (3, 4), the conversion material (1) being embedded in the matrix material (2).

Classes IPC  ?

• C08L 83/06 - Polysiloxanes contenant du silicium lié à des groupes contenant de l'oxygène
• C09D 183/06 - Polysiloxanes contenant du silicium lié à des groupes contenant de l'oxygène
• H01L 33/50 - DISPOSITIFS À SEMI-CONDUCTEURS NON COUVERTS PAR LA CLASSE - Détails caractérisés par les éléments du boîtier des corps semi-conducteurs Éléments de conversion de la longueur d'onde

Abrégé

The present invention is in the field of processes for the generation of thin inorganic films on substrates, in particular atomic layer deposition processes. It relates to a process for preparing metal- or semimetal-containing films comprising (a) depositing a metal- or semimetal-containing compound from the gaseous state onto a solid substrate and (b) bringing the solid substrate with the deposited metal- or semimetal-containing compound in contact with compound of general formula (II), (III), or (IV), wherein E is Ge or Sn, R is an alkyl group, an alkenyl group, an aryl group, or a silyl group, R' are an alkyl group, an alkenyl group, an aryl group, or a silyl group, X is nothing, hydrogen, a halide, an alkyl group, an alkylene group, an aryl group, an alkoxy group, an aryl oxy group, an amino group, or a amidinate group, or an guanidinate group, L is an alkyl group, an alkenyl group, an aryl group, or a silyl group.

Classes IPC  ?

• C23C 16/18 - Revêtement chimique par décomposition de composés gazeux, ne laissant pas de produits de réaction du matériau de la surface dans le revêtement, c.-à-d. procédés de dépôt chimique en phase vapeur [CVD] caractérisé par le dépôt d'un matériau métallique à partir de composés organométalliques
• C23C 16/06 - Revêtement chimique par décomposition de composés gazeux, ne laissant pas de produits de réaction du matériau de la surface dans le revêtement, c.-à-d. procédés de dépôt chimique en phase vapeur [CVD] caractérisé par le dépôt d'un matériau métallique
• C23C 16/455 - Revêtement chimique par décomposition de composés gazeux, ne laissant pas de produits de réaction du matériau de la surface dans le revêtement, c.-à-d. procédés de dépôt chimique en phase vapeur [CVD] caractérisé par le procédé de revêtement caractérisé par le procédé utilisé pour introduire des gaz dans la chambre de réaction ou pour modifier les écoulements de gaz dans la chambre de réaction

Abrégé

The invention relates to an apparatus (1; 1a; 1b; 1c; 1d; 1e) for producing a cast part (36) formed from an amorphous or partially amorphous metal, which comprises a cast part mold (3; 3a; 3b; 3c; 3d; 3e) having at least one fill opening (16; 16a; 16b, 41; 16c: 16d; 16e) for introducing a casting material (15; 15a; 15b; 15c; 15d; 15e) forming the cast part (36) and a device for melting the casting material (15; 15a; 15b; 15c; 15d; 15e). The melting device expediently has at least one region (13; 13; 13b; 40, 13c; 13d; 13e) which is provided for melting the casting material (15; 15a; 15b; 15c; 15d; 15e). According to the invention, an apparatus is advantageously created which enables particularly precise introduction of melt energy into the casting material. In one embodiment, the melting device has means for forming at least one electric arc (30; 30a, 39) in the at least one melting region (13; 13; 13b; 40, 13c; 13d; 13e), which particularly comprises at least two electrodes arranged at a distance from each other (32; 32a, 38; 32b; 32c), between which the at least one electric arc (30; 30a, 39) can be formed.

Classes IPC  ?

• B22D 17/12 - Machines à chambre froide, c.-à-d. dont la chambre de presse où on verse le métal liquide, n'est pas préchauffée avec mouvement vertical de la presse
• B22D 17/20 - AccessoiresCoulée sous pression ou moulage par injection, c.-à-d. moulage en introduisant le métal dans le moule sous haute pression Parties constitutives
• B22D 17/28 - Creusets
• B22D 17/30 - Accessoires pour l'alimentation en métal liquide, p. ex. en quantités bien définies
• B22D 27/04 - Action sur la température du métal, p. ex. par chauffage ou refroidissement du moule
• C22C 1/00 - Fabrication des alliages non ferreux
• C22C 1/02 - Fabrication des alliages non ferreux par fusion

Abrégé

ttt).

Classes IPC  ?

• G01N 33/00 - Recherche ou analyse des matériaux par des méthodes spécifiques non couvertes par les groupes
• G01N 1/40 - Concentration des échantillons

Abrégé

The present invention relates a method for detecting high grade dysplasia, for assaying the potential for the development of carcinoma and for verifying whether a sample, which was determined to contain cells with high grad dysplasia, indeed contains cells with high grade dysplasia. Further provided is the use of agents for the detection of Sec62 and Ki67 in an in vitro-method for the detection of high grade dysplasia and for the reduction of false-positive results. Furthermore, a kit for the detection of high grad dysplasia is provided as well.

Classes IPC  ?

• G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer

Abrégé

The present invention relates to a polynucleotide encoding NCgl0464, a host cell comprising said polynucleotide and optionally further polynucleotides. It also provides for a use of the polynucleotides, vectors or host cell for the production of glutarate and methods for producing glutarate. NCgl0464 is a 5-aminovalerate permease to be overexpressed and the further polynucleotides may encode gabT, gabA, gabB and/or gabT to be overexpressed. Also, a polynucleotide encoding lysE may be inactivated in the host cell.

Classes IPC  ?

• C12N 15/09 - Technologie d'ADN recombinant
• C12R 1/13 - Brevibacterium
• C07K 14/395 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de champignons provenant de levures provenant de Saccharomyces

Abrégé

The present invention relates to a mi R-34a modulating compound for use in the treatment of a disease accompanied by an impaired T-cell receptor signaling. Further, the present invention relates to a method of determining whether a patient responds to a treatment of a disease accompanied by an impaired T-cell receptor signaling. Furthermore, the present invention relates to a mi R-34a binding molecule for use in the treatment of a disease accompanied by an impaired calcium signaling. In addition, the present invention relates to a method of determining whether a patient responds to a treatment of a disease accompanied by an impaired calcium signaling.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• A61K 31/7088 - Composés ayant au moins trois nucléosides ou nucléotides

Abrégé

The invention relates to a method for the leakage measurement of a test object (2) that is filled or can be filled with a test fluid (21), said method comprising the following steps: arranging (S1) the test object (2) in a sealed test chamber (3) filled with a reference fluid (31), in order to enrich potentially escaping test fluid (21) in the reference fluid (31) in the test chamber (3); operating (S3, S6) a fluid sensor (91, 91') that is sensitive to at least one constituent of the test fluid (21) in order to energise same with a power supply and to form a quantity of a chemical reaction partner exceeding a thermodynamic equilibrium on a sensor surface of the fluid sensor (91, 91'), the quantity of chemical reaction partner exceeding a thermodynamic equilibrium influencing an electrical property of the fluid sensor (91, 91'); following a successful energising of the fluid sensor (91, 91'), applying (S7) at least part of the reference fluid (31) potentially contaminated with test fluid (21) to the sensor surface (93) over a measurement period such that an electrical property is modified as a result of an interaction of the test fluid (21) with the reaction partners; and determining (S8, S9) a leakage indication according to the modification of the electrical property of the fluid sensor (91, 91') as a result of the application of the contaminated reference fluid (31) to the sensor surface (93).

Classes IPC  ?

• G01M 3/04 - Examen de l'étanchéité des structures ou ouvrages vis-à-vis d'un fluide par utilisation d'un fluide ou en faisant le vide par détection de la présence du fluide à l'emplacement de la fuite
• G01M 3/18 - Examen de l'étanchéité des structures ou ouvrages vis-à-vis d'un fluide par utilisation d'un fluide ou en faisant le vide par détection de la présence du fluide à l'emplacement de la fuite en utilisant des moyens de détection électrique pour tuyaux, câbles ou tubesExamen de l'étanchéité des structures ou ouvrages vis-à-vis d'un fluide par utilisation d'un fluide ou en faisant le vide par détection de la présence du fluide à l'emplacement de la fuite en utilisant des moyens de détection électrique pour raccords ou étanchéité de tuyauxExamen de l'étanchéité des structures ou ouvrages vis-à-vis d'un fluide par utilisation d'un fluide ou en faisant le vide par détection de la présence du fluide à l'emplacement de la fuite en utilisant des moyens de détection électrique pour soupapes
• G01M 3/22 - Examen de l'étanchéité des structures ou ouvrages vis-à-vis d'un fluide par utilisation d'un fluide ou en faisant le vide par détection de la présence du fluide à l'emplacement de la fuite en utilisant des révélateurs particuliers, p. ex. teinture, produits fluorescents, produits radioactifs pour tuyaux, câbles ou tubesExamen de l'étanchéité des structures ou ouvrages vis-à-vis d'un fluide par utilisation d'un fluide ou en faisant le vide par détection de la présence du fluide à l'emplacement de la fuite en utilisant des révélateurs particuliers, p. ex. teinture, produits fluorescents, produits radioactifs pour raccords ou étanchéité de tuyauxExamen de l'étanchéité des structures ou ouvrages vis-à-vis d'un fluide par utilisation d'un fluide ou en faisant le vide par détection de la présence du fluide à l'emplacement de la fuite en utilisant des révélateurs particuliers, p. ex. teinture, produits fluorescents, produits radioactifs pour soupapes

Abrégé

233-alkenyl-substituted compound of formula (I) wherein m is 1,2 or 3; Rm1, Rm2, Rm3and Rm461412461411010- alkylene; R5, R661414-aryl, or R5and R6together are a diradical of the formula A; A is a diradical of the formulae A.1 or A.2 wherein R7233-alkenyl; R8, n are are as defined in the claims and in the description. The present invention also relates to a polymer comprising in copolymerized form at least one compound of formula I and an organopolysiloxane and to novel compounds of formula (I).

Classes IPC  ?

• C07D 471/06 - Systèmes condensés en péri

Abrégé

The present invention relates to methods for determining Alzheimer's Disease (AD) in a patient. Further, the present invention relates to uses of polynucleotides for detecting mi RNAs in a blood sample isolated from a patient for determining Alzheimer's Disease in the patient. Furthermore, the invention relates to kits for determining Alzheimer's Disease in a patient.

Classes IPC  ?

• C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique

Abrégé

The invention relates to alloys forming metallic glasses containing sulphur and a method for the production thereof.

Classes IPC  ?

• C22C 1/00 - Fabrication des alliages non ferreux
• B22F 9/00 - Fabrication des poudres métalliques ou de leurs suspensionsAppareils ou dispositifs spécialement adaptés à cet effet
• C22C 45/00 - Alliages amorphes
• C22C 45/02 - Alliages amorphes avec le fer comme constituant majeur
• C22C 45/04 - Alliages amorphes avec le nickel ou le cobalt comme constituant majeur
• C22C 45/10 - Alliages amorphes avec le molybdène, le tungstène, le niobium, le tantale, le titane ou le zirconium comme constituant majeur

Abrégé

The present invention relates to a method for diagnosing Parkinson's disease (PD) in an individual. Further, the present invention relates to a method for determining the course of Parkinson's disease (PD) in an individual having PD. Furthermore, the present invention relates to a method for determining the risk for developing Parkinson's disease (PD) in an individual. In addition, the present invention relates to the use of at least one polynucleotide for detecting at least one miRNA in a biological sample isolated from an individual for diagnosing Parkinson's disease (PD) in the individual, the use of at least one polynucleotide for detecting at least one miRNA in a biological sample isolated from an individual having Parkinson's disease (PD) for determining the course of PD in the individual, and/or the use of at least one polynucleotide for detecting at least one miRNA in a biological sample isolated from an individual for determining the risk of the individual to develop Parkinson's disease (PD). Moreover, the present invention relates to a kit for diagnosing Parkinson's disease (PD) in an individual, for determining the course of Parkinson's disease (PD) in an individual having PD, and/or for determining the risk for developing Parkinson's disease (PD) in an individual.

Classes IPC  ?

• C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique

Abrégé

The invention relates to a coating or a body provided with a coating. The coating is at least partly made of a composite material which comprises a porous support that has a metal core surrounded with a metal oxide. According to the invention, a polyphosphazene is bonded to the support. Expediently, the polyphosphazene is chemically bonded to the support, preferably via a covalent bond, and has poly(bis(trifluoroethoxy)phosphazene (PTFEP). In one embodiment of the invention, the support has a plurality of nanowires which are crosslinked preferably with one another. The metal of the metal oxide and the metal of the core are expediently a metal of the third main group, preferably the metal of the core is aluminum or gallium, and the metal oxide is aluminum oxide or gallium oxide. In one embodiment of the invention, the polyphosphazene coats the support, in particular the nanowires, in a thin layer such that the structure formed by the nanowires remains at least on the surface of the coating. The invention further relates to a method for producing the coating or the body.

Classes IPC  ?

• B05D 5/08 - Procédés pour appliquer des liquides ou d'autres matériaux fluides aux surfaces pour obtenir des effets, finis ou des structures de surface particuliers pour obtenir une surface antifriction ou anti-adhésive
• A61L 27/04 - Métaux ou alliages
• A61L 27/34 - Matériaux macromoléculaires
• A61L 27/50 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
• A61L 33/00 - Traitement antithrombogénique d'articles chirurgicaux, p. ex. de sutures, cathéters, prothèses ou d'articles pour la manipulation ou le conditionnement du sangMatériaux pour un tel traitement
• B82Y 30/00 - Nanotechnologie pour matériaux ou science des surfaces, p. ex. nanocomposites
• C08G 79/025 - Polyphosphazènes
• C08L 85/02 - Compositions contenant des composés macromoléculaires obtenus par des réactions créant dans la chaîne principale de la macromolécule une liaison contenant des atomes autres que le silicium, le soufre, l'azote, l'oxygène et le carboneCompositions contenant des dérivés de tels polymères contenant du phosphore
• B05D 1/18 - Procédés pour appliquer des liquides ou d'autres matériaux fluides aux surfaces par immersion

Abrégé

The invention relates to methods for diagnosing Parkinson's Disease PAD) with miRNA markers. Towards the identification of biomarkers for diagnosis of PD, a comprehensive analysis of miRNA expression patterns was obtained. Significantly deregulated miRNAs were identified.

Classes IPC  ?

• C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
• G16B 25/00 - TIC spécialement adaptées à l’hybridationTIC spécialement adaptées à l’expression de gènes ou de protéines
• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux

Abrégé

Conversion of organic educts, in particular biomass feedstock, into useful organic compounds via pyrolysis and biocatalysts.

Classes IPC  ?

• C12P 7/44 - Acides polycarboxyliques
• C10B 53/02 - Distillation destructive spécialement conçue pour des matières premières solides particulières ou sous forme spéciale de matières contenant de la cellulose
• C10C 5/00 - Production d'acide pyroligneux
• C07C 39/08 - DihydroxybenzènesLeurs dérivés alkylés
• C07C 4/04 - Procédés thermiques
• C07C 63/26 - Acide benzènedicarboxylique-1, 4
• C07D 201/08 - Préparation des lactames à partir d'acides carboxyliques ou de leurs dérivés, p. ex. d'acides hydroxycarboxyliques, de lactones, de nitriles
• C08L 77/06 - Polyamides dérivés des polyamines et des acides polycarboxyliques
• C12N 1/21 - BactériesLeurs milieux de culture modifiés par l'introduction de matériel génétique étranger
• C12N 15/01 - Préparation de mutants sans introduction de matériel génétique étrangerProcédés de criblage à cet effet

Abrégé

The present invention generally relates to the field of virology and cellular biology. Specifically, the invention provides novel means and methods for cultivating BK polyomavirus. Also provided are novel screening methods for potential inhibitors of BK polyomavirus replication.

Classes IPC  ?

• C12N 5/071 - Cellules ou tissus de vertébrés, p. ex. cellules humaines ou tissus humains
• C12N 7/00 - Virus, p. ex. bactériophagesCompositions les contenantLeur préparation ou purification
• C12N 7/02 - Isolement ou purification
• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
• A61K 31/167 - Amides, p. ex. acides hydroxamiques ayant des cycles aromatiques, p. ex. colchicine, aténolol, progabide ayant l'atome d'azote d'un groupe carboxamide lié directement au cycle aromatique, p. ex. lidocaïne, paracétamol
• A61K 31/192 - Acides carboxyliques, p. ex. acide valproïque ayant des groupes aromatiques, p. ex. sulindac, acides 2-aryl-propioniques, acide éthacrynique
• A61K 31/203 - Acides rétinoïques

Abrégé

The present invention relates generally to a sensor for tumor tissue and a local release system for releasing therapeutic agents/diagnostic agents for targeted tumor therapy and diagnosis. More specifically, the invention relates to a cation-stabilised biopolymer gel, in particular an alginate gel, for use as a carrier matrix for a tumor therapeutic agent and/or tumor diagnostic agent, characterised in that the gel destabilises in the presence of a stimulus, in particular lysyl oxidase (LOX), generated by tumor cells or tumor tissue and the tumor therapeutic agent and/or tumor diagnostic agent can be released, and a pharmaceutical composition that comprises this cation-stabilised biopolymer gel with incorporated tumor therapeutic agent and/or tumor diagnostic agent and optionally an additional reporter substance. An associated aspect of the invention relates to an in vitro method for determining the presence and/or amount of a tumor-specific product in the body of a patient, characterised in that a physiological sample from a patient to whom a pharmaceutical composition according to the invention has been administered is examined to ascertain the presence and/or amount of a reporter substance that has been released after destabilisation of the gel as a result of contact with the tumor-specific product to be determined, and optionally compared with reference values.

Classes IPC  ?

• A61K 9/48 - Préparations en capsules, p. ex. de gélatine, de chocolat
• C12Q 1/26 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une oxydoréductase
• G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
• A61P 35/00 - Agents anticancéreux

Abrégé

In one embodiment the invention relates to a method of preparing a polyrotaxane, said method comprising: performing a radical copolymerization of at least (a) a first polymerizable monomer having a stopper group, and of at least (b) a second polymerizable hydrophobic monomer, wherein said second monomer is complexed by a ring-shaped molecule, and of at least (c) a third polymerizable hydrophilic monomer; wherein during said copolymerization a copolymer threading said ring-shaped molecule is formed, wherein during said copolymerization said first monomer having a stopper group is incorporated into the chain of said copolymer at least partially between the ends thereof, and wherein said stopper groups prevent said ring-shaped molecule from disassembling from the copolymer; and wherein the amount of said first monomer having a stopper group is of from 0.1 mol % to 20 mol % based on 100 mol % of the total amount of polymerizable monomers. In another embodiment the invention relates to a method of preparing a polyrotaxane, said method comprising: performing a radical copolymerization of at least (a) a first polymerizable monomer having a stopper group, and of at least (b) a second polymerizable partially hydrophilic monomer, wherein said second monomer is complexed by a ring-shaped molecule, and wherein said second monomer has a solubility in water at 20°C of from 5 g/L to 40 g/L; wherein during said copolymerization a copolymer threading said ring-shaped molecule is formed, wherein during said copolymerization said first monomer having a stopper group is incorporated into the chain of said copolymer at least partially between the ends thereof, and wherein said stopper groups prevent said ring-shaped molecule from disassembling from the copolymer; and wherein the amount of said first monomer having a stopper group is of from 0.1 mol % to 20 mol % based on 100 mol % of the total amount of polymerizable monomers. Furthermore, the present invention relates to methods of preparing cross-linked polyrotaxanes and cross-linked polyrotaxanes which can be prepared using such methods. Thus, the present invention also relates to polyrotaxane and crosslinked polyrotaxanes. The invention also relates to products which contain the polyrotaxanes or cross- linked polyrotaxanes or which can be prepared from the polyrotaxanes or the cross-linked polyrotaxanes. The present invention further relates to the use of polyrotaxanes or cross-linked polyrotaxanes in various applications, such as the use as a self-healing material.

Classes IPC  ?

• C08G 83/00 - Composés macromoléculaires non prévus dans les groupes
• C08J 3/075 - Gels macromoléculaires
• C08J 3/24 - Réticulation, p. ex. vulcanisation, de macromolécules

Abrégé

The present invention is in the field of processes for the generation of thin inorganic films on substrates. In particular, the present invention relates to a process for producing an inorganic silicon-containing film comprising depositing the compound of general formula (I) onto a solid substrate, wherein R1, R2, R3 and R4 are an alkyl group, an alkenyl group, an aryl group, a silyl group, or an amine group, and wherein at least one of R1 and R2 and at least one of R3 and R4 is a branched group containing at least five non-hydrogen atoms and wherein not more than one of R1 and R2 and not more than one of R3 and R4 is an amine group.

Classes IPC  ?

• C23C 16/34 - Nitrures
• C07F 7/08 - Composés comportant une ou plusieurs liaisons C—Si
• C23C 16/40 - Oxydes
• C23C 16/455 - Revêtement chimique par décomposition de composés gazeux, ne laissant pas de produits de réaction du matériau de la surface dans le revêtement, c.-à-d. procédés de dépôt chimique en phase vapeur [CVD] caractérisé par le procédé de revêtement caractérisé par le procédé utilisé pour introduire des gaz dans la chambre de réaction ou pour modifier les écoulements de gaz dans la chambre de réaction

Abrégé

The present invention relates to methods for predicting whether a pre-implanted embryo will be embedded into the endometrium of a female. The present invention further relates to a kit for predicting whether a pre-implanted embryo will be embedded into the endometrium of a female.

Classes IPC  ?

• C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
• C12Q 1/6888 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes

Abrégé

The invention is directed to a method and a device for controlling images in a head mounted display equipped with an eye tracker and worn by a user, comprising the following steps: detecting, with the eye-tracker, an eye gaze of at least one of the eyes of the user; controlling the images depending on the detected eye gaze; wherein the step of controlling the images comprises not rendering or not updating pixels (22) of the images that are not visible by the user at the detected eye gaze.

Classes IPC  ?

• G06F 3/01 - Dispositions d'entrée ou dispositions d'entrée et de sortie combinées pour l'interaction entre l'utilisateur et le calculateur

Abrégé

The invention relates to a refrigerated vehicle (200), which is configured for transporting samples at a temperature below - 80°C, which refrigerated vehicle comprises a refrigerated container (100) and a chassis (60) to which the refrigerated container (100) is fixedly connected, wherein the refrigerated container (100) comprises an inner container (10) enclosing an interior space (11) for receiving the samples, a refrigeration unit device (20) which is configured for passive cooling of the interior space (11), container walls (30) which delimit the inner container (10) on horizontal sides and on a base side, and a container lid (40) by which the inner container (10) can be closed on a top side of the refrigerated vehicle (100), wherein the container walls (30) have a layer structure with a plurality of wall layers which comprise at least one thermal insulation layer and an outer impact protection layer, and at least one of the container walls (30) has a hollow space which, in different operating phases of the refrigerated vehicle (200), in each case can be evacuated or can be supplied with a working gas. The invention further relates to a method for transporting samples at a temperature below -80°C by the refrigerated vehicle.

Classes IPC  ?

• F25D 3/10 - Dispositifs utilisant d'autres agents froidsDispositifs utilisant des récipients conservant le froid utilisant des gaz liquéfiés, p. ex. de l'air liquide
• F28F 13/00 - Dispositions pour modifier le transfert de chaleur, p. ex. accroissement, diminution
• F25D 3/00 - Dispositifs utilisant d'autres agents froidsDispositifs utilisant des récipients conservant le froid

Abrégé

The invention relates to a refrigerated container (100), which is configured for storing and/or transporting samples at a temperature below -80 °C, and which comprises an inner container (10) enclosing an interior space (11) for receiving the samples, a refrigeration unit device (20) which is configured for passive cooling of the interior space (11), container walls (30) which delimit the inner container (10) on horizontal sides and on a base side, and a container lid (40) by which the inner container (10) can be closed on a top side of the refrigerated vehicle (100), wherein the container walls (30) have a layer structure with a plurality of wall layers which comprise at least one thermal insulation layer and an outer impact protection layer, and at least one of the container walls (30) has a hollow space which, in different operating phases of the refrigerated vehicle (200), in each case can be evacuated (52) or can be supplied with a working gas (53). The invention further relates to a method for storing and/or for transporting samples at a temperature below -80°C by the refrigerated container.

Classes IPC  ?

• F25D 3/10 - Dispositifs utilisant d'autres agents froidsDispositifs utilisant des récipients conservant le froid utilisant des gaz liquéfiés, p. ex. de l'air liquide
• F25D 3/00 - Dispositifs utilisant d'autres agents froidsDispositifs utilisant des récipients conservant le froid
• F28F 13/00 - Dispositions pour modifier le transfert de chaleur, p. ex. accroissement, diminution

Abrégé

A white gold alloy of the composition (Au1-a-bAga(Pd1-cPtc)b)100-x-y(Cu1-d- eLdMe)x(Si1-fGef)y has been produced in which L represents In, Ga or Sn or Ld represents L1 d1L2 d2 or L1 d1L2 d2L3 d3, wherein L1, L2 and L3 are selected from the elements In, Ga, or Sn; M represents one or more elements of the elements Ni, Co, and Fe; x and y are at%, wherein x = 10 - 30 at% and y = 10 - 16.3 at%; (100-x-y), x, and y can contain unavoidable trace impurities; a, b, c, d, e, and f are a fraction of 1; a = 0.02 - 0.20, b = 0 - 0.1, c = 0 - 1, d = 0.02 -0.40, d1 = 0 to 0.4; d2 = 0 to 0.4; and d3 = 0 to 0.4, where d1 + d2 + d3 = d, e = 0 - 0.12 (total fraction of the elements Ni, Co, and Fe) and f = 0 - 0.40. The white gold alloy is suitable for a broad range of solid glass forming processes and for jewelry applications.

Classes IPC  ?

• C22C 5/02 - Alliages à base d'or
• C22C 45/00 - Alliages amorphes

Abrégé

In a computer-implemented method for improving the quality of medical ultrasound images, ultrasound data of a test person are obtained. The obtained data are subjected to an automated analysis as to whether a change of a parameter for detection of the ultrasound data, in particular an administration of ultrasound contrast medium to the test person, a change of the contrast setting, a signal amplification, the irradiated wavelength, or the received wavelength, improves a given quality standard of the ultrasound based on the ultrasound data. Lastly, an indicator is output to a user, based on the analysis of whether the change of the parameter improves a quality of the ultrasound data.

Classes IPC  ?

• G06F 19/00 - Équipement ou méthodes de traitement de données ou de calcul numérique, spécialement adaptés à des applications spécifiques (spécialement adaptés à des fonctions spécifiques G06F 17/00;systèmes ou méthodes de traitement de données spécialement adaptés à des fins administratives, commerciales, financières, de gestion, de surveillance ou de prévision G06Q;informatique médicale G16H)

Abrégé

The invention relates to an actuator device (1) for providing at least two actuator positions, comprising an elastic bending element (2), which at at least one fastening point (31, 32, 34) is held such that by exerting a switching torque at the fastening point (31, 32, 34), an elastic deformation of the bending element (2) leads to a change from a first actuator position into a second actuator position, and comprising at least one actuator element (41, 42) having a shape memory wire, wherein by heating, the shape memory wire generates a tractive force, and is thus coupled to a section of the bending element (2) at the fastening point (31, 32, 34), such that the tractive force causes the switching moment to be brought about at the fastening point (31, 32, 34) in order to move the bending element (2) from the first actuator position into the second actuator position.

Classes IPC  ?

• F03G 7/06 - Mécanismes produisant une puissance mécanique, non prévus ailleurs ou utilisant une source d'énergie non prévue ailleurs utilisant la dilatation ou la contraction des corps produites par le chauffage, le refroidissement, l'humidification, le séchage ou par des phénomènes similaires
• G05G 1/02 - Organes de commande actionnés à la main par un mouvement linéaire, p. ex. boutons poussoirs
• G05G 5/06 - Moyens pour empêcher, limiter ou inverser le mouvement de certaines pièces d'un mécanisme de commande, p. ex. verrouillage des organes de commande pour maintenir les organes de commande, seulement sur une ou sur un nombre limité de positions définies
• H01L 41/09 - Eléments piézo-électriques ou électrostrictifs à entrée électrique et sortie mécanique

Abrégé

In a method and an evaluation device for the evaluation of projection data of an object being examined, which are determined along a trajectory in a multiplicity of projection positions relative to a co-ordinate origin, a particular trajectory function is determined for the projection positions, for each of a multiplicity of positions from a reconstruction region of dimension n by establishing an offset (d) and a direction vector at the co-ordinate origin, establishing a hyperplane of dimension n−1 which runs perpendicular to the direction vector and has an offset to the co-ordinate origin, establishing a number of intersection points where the hyperplane intersects the trajectory, establishing a derivative vector of the trajectory according to its trajectory path and calculating the derivative vector in the projection position, and establishing an absolute value of a scalar product between the derivative vector and the position and dividing the absolute value by the number. The determined trajectory functions are transformed to a frequency domain of dimension n and the projection data are evaluated by means of the transformed trajectory functions.

Classes IPC  ?

• G06T 11/00 - Génération d'images bidimensionnelles [2D]

Abrégé

According to some aspects, a method is provided of producing multicolor objects via additive fabrication by forming a plurality of layers on a substrate from a plurality of materials each having a respective color, the method comprising obtaining image data, the image data indicating a color for each of a plurality of positions, determining a plurality of color stacks based on the image data, each color stack being determined based on the color associated with one of the plurality of positions of the image data, and each color stack specifying a sequence of materials, where each material in the sequence is selected from amongst the plurality of materials, and forming, via additive fabrication, a plurality of layers from the plurality of materials according to the specified sequence of materials associated with each color stack.

Classes IPC  ?

• B05D 5/06 - Procédés pour appliquer des liquides ou d'autres matériaux fluides aux surfaces pour obtenir des effets, finis ou des structures de surface particuliers pour obtenir des effets multicolores ou d'autres effets optiques
• B29C 35/08 - Chauffage ou durcissement, p. ex. réticulation ou vulcanisation utilisant l'énergie ondulatoire ou un rayonnement corpusculaire
• B33Y 10/00 - Procédés de fabrication additive
• B33Y 50/02 - Acquisition ou traitement de données pour la fabrication additive pour la commande ou la régulation de procédés de fabrication additive
• H04N 1/60 - Correction ou commande des couleurs

Abrégé

The invention is directed to an object (2) with a three-dimensional shape made of a folded sheet (4) so as to form at least one face (6), at least one corner (10) and/or at least one edge (8), the object comprising electrically conductive traces (14) printed on the sheet (4); and at least one functional area (12) printed on one of the at least one face (6), adjacent to one of the at least one edge (8), or adjacent to one of the at least one corner (10), the at least one functional area (12) being electrically connected to the conductive traces (14) and forming at least one control for a touch input, for a display output, and/or for sensing a change of shape of the object.

Classes IPC  ?

• H05K 1/02 - Circuits imprimés Détails
• H05K 1/11 - Éléments imprimés pour réaliser des connexions électriques avec ou entre des circuits imprimés
• H05K 1/16 - Circuits imprimés comprenant des composants électriques imprimés incorporés, p. ex. une résistance, un condensateur, une inductance imprimés
• H01G 4/33 - Condensateurs à film mince ou à film épais
• G09F 9/30 - Dispositifs d'affichage d'information variable, dans lesquels l'information est formée sur un support, par sélection ou combinaison d'éléments individuels dans lesquels le ou les caractères désirés sont formés par une combinaison d'éléments individuels
• G06F 3/044 - Numériseurs, p. ex. pour des écrans ou des pavés tactiles, caractérisés par les moyens de transduction par des moyens capacitifs
• H05K 3/00 - Appareils ou procédés pour la fabrication de circuits imprimés
• G06T 17/00 - Modélisation tridimensionnelle [3D] pour infographie
• H05K 1/03 - Emploi de matériaux pour réaliser le substrat
• H05K 3/12 - Appareils ou procédés pour la fabrication de circuits imprimés dans lesquels le matériau conducteur est appliqué au support isolant de manière à former le parcours conducteur recherché utilisant la technique de l'impression pour appliquer le matériau conducteur

Abrégé

The present invention relates to the field of biotechnology. It involves the decomposition and conversion of organic educts, in particular biomass feedstock, lignin, guaiacol; p-coumaryl alcohol; coniferyl alcohol; sinapyl alcohol; cresol; phenol; catechol; polysaccharides; cellulose hemicellulose; xylose; glucose; fructose; proteins; amino acids; triacylglycerides and/or fatty acids into useful organic compounds with the help of biocatalysts. A method of producing an organic product comprises i) fluid-assisted decomposition of an organic educt under sub- or supercritical conditions ii) obtaining an intermediate product from step i) iii) subjecting the intermediate product to biocatalytic conversion, by contacting the intermediate product obtained in step ii) with a biocatalyst, wherein said biocatalyst is a host cell selected from the group consisting of bacteria, yeast, filamentous fungi, cyanobacteria, algae, and plant cells. Further, a host cell is provided herein that can advantageously be employed in the methods of the invention.

Classes IPC  ?

• C12P 7/10 - Éthanol en tant que produit chimique et non en tant que boisson alcoolique préparé comme sous-produit, ou préparé à partir d'un substrat constitué par des déchets ou par des matières cellulosiques d'un substrat constitué par des matières cellulosiques
• C12P 7/44 - Acides polycarboxyliques
• C12N 9/02 - Oxydoréductases (1.), p. ex. luciférase

Abrégé

The present invention relates to methods for diagnosis and/or prognosis of a HPV- induced precancerous lesion or a HPV-induced cancer. Also provided are methods for detecting cells of the transition zones zone of the cervix uteri, anorectal region, oropharynx, penis or vulva. In addition, the present invention encompasses uses of LGR6, LGR5 and/or LGR4 and kits comprising means for detecting these marker(s).

Classes IPC  ?

• C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
• C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
• G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer

Abrégé

The present invention relates to a method of converting an alcohol into a corresponding halide. This method comprises reacting the alcohol with an optionally substituted aromatic carboxylic acid halide in presence of an N-substituted formamide to replace a hydroxyl group of the alcohol by a halogen atom. The present invention also relates to a method of converting an alcohol into a corresponding substitution product. The second method comprises: (a) performing the method of the invention of converting an alcohol into the corresponding halide; and (b) reacting the corresponding halide with a nucleophile to convert the halide into the nucleophilic substitution product.

Classes IPC  ?

• C07C 17/16 - Préparation d'hydrocarbures halogénés par remplacement par des halogènes de groupes hydroxyle
• C07C 22/04 - Composés cycliques contenant des atomes d'halogène liés à un atome de carbone acyclique ayant une insaturation dans les cycles contenant des cycles aromatiques à six chaînons
• C07C 21/067 - Chlorure d'allyleChlorure de méthallyle
• C07B 39/00 - Halogénation

Abrégé

The present invention relates to a method of preparing a polyrotaxane, said method comprising: performing a radical copolymerization of at least (a) a first polymerizable monomer having a stopper group, and of at least (b) a second polymerizable monomer, wherein said second monomer is complexed by a ring-shaped molecule; wherein during said copolymerization a copolymer threading said ring-shaped molecule is formed, wherein during said copolymerization said first monomer having a stopper group is incorporated into the chain of said copolymer at least partially between the ends thereof, and wherein said stopper groups prevent said ring-shaped molecule from disassembling from the copolymer; and wherein the amount of said first monomer having a stopper group is of from 0.1 mol % to 20 mol % based on 100 mol % of the total amount of polymerizable monomers. The present invention also relates to polyrotaxanes which can be prepared by using such a method. The present invention further relates to cross-linked polyrotaxanes, products which contain polyrotaxanes or cross-linked polyrotaxanes or which can be prepared from polyrotaxanes or cross- linked polyrotaxanes, and the use of polyrotaxanes or cross-linked polyrotaxanes.

Classes IPC  ?

• C08G 83/00 - Composés macromoléculaires non prévus dans les groupes
• C08F 236/04 - Copolymères de composés contenant plusieurs radicaux aliphatiques non saturés et l'un au moins contenant plusieurs liaisons doubles carbone-carbone le radical ne contenant que deux doubles liaisons carbone-carbone conjuguées
• C08F 236/08 - Isoprène
• C08J 3/075 - Gels macromoléculaires
• C08J 3/24 - Réticulation, p. ex. vulcanisation, de macromolécules
• C08L 53/02 - Compositions contenant des copolymères séquencés possédant au moins une séquence d'un polymère obtenu par des réactions ne faisant intervenir que des liaisons non saturées carbone-carboneCompositions contenant des dérivés de tels polymères contenant des monomères vinylaromatiques et des diènes conjugués

Abrégé

The present invention provides means and methods for diagnosing or treating B-cell malignancies. Novel conjugates for reverse targeting of B-cell receptors on malignant B cells are provided. The conjugates comprise a BCR antigen and a diagnostic or therapeutic agent. Also provided herein is a method for identifying patients disposed to respond favorably to treatment with a BCR antigen conjugate of the invention.

Classes IPC  ?

• A61K 47/48 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. supports, additifs inertes l'ingrédient non actif étant chimiquement lié à l'ingrédient actif, p.ex. conjugués polymère-médicament
• A61P 35/00 - Agents anticancéreux

Abrégé

The invention relates to a method and a device for optical in vitro detection of a movement in a biological sample with a spatial extent in the form of a three-dimensional cell and/or tissue culture or a cell cluster or a sample made of freely swimming microorganisms. The method comprises the following steps: (a) providing a receptacle for the sample (1), a light beam source (6), an optical unit (7, 8) and a detector (2), (a1) wherein the optical unit (7, 8) is embodied to illuminate the whole sample (1) in the receptacle with radiation emanating from the light beam source and to guide at least some of the radiation (11) of the light beam source (6), which is changed at any point within the sample (1) by an interaction with the sample (1) in terms of the beam direction thereof, the polarization state thereof and/or the diffraction pattern thereof, to a detection surface (2a) of the detector (2), and (a2) wherein the detector (2) is embodied to generate a measurement signal (9) in a manner dependent on the detected radiation, the time profile of which measurement signal specifies a time profile of an intensity of the detected radiation (11) and/or from which the time profile of the intensity of the detected radiation (11) is derivable; (b) illuminating the sample (1) with radiation from the light beam source; and (c) detecting a movement in the biological sample (1) in a manner dependent on a temporal change in the measurement signal (9).

Classes IPC  ?

• G01N 21/21 - Propriétés affectant la polarisation
• G01P 13/00 - Indication ou enregistrement de l'existence ou de l'absence d'un mouvementIndication ou enregistrement de la direction d'un mouvement
• G01N 21/47 - Dispersion, c.-à-d. réflexion diffuse
• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
• G01N 21/49 - Dispersion, c.-à-d. réflexion diffuse dans un corps ou dans un fluide

Abrégé

We present sandbox mining, a technique to confine an computer program to computing resources accessed during automatic testing. Sandbox mining first explores software behavior by means of automatic test generation, and extracts the set of resources accessed during these tests. This set is then used as a sandbox, blocking access to resources not used during testing. The mined sandbox thus protects against behavior changes such as the activation of latent malware, infections, targeted attacks, or malicious updates. The use of test generation makes sandbox mining a fully automatic process that can be run by vendors and end users alike.

Classes IPC  ?

• G06F 21/53 - Contrôle des utilisateurs, des programmes ou des dispositifs de préservation de l’intégrité des plates-formes, p. ex. des processeurs, des micrologiciels ou des systèmes d’exploitation au stade de l’exécution du programme, p. ex. intégrité de la pile, débordement de tampon ou prévention d'effacement involontaire de données par exécution dans un environnement restreint, p. ex. "boîte à sable" ou machine virtuelle sécurisée

Abrégé

The present invention relates to a method and a device for emulating frame rates in video or motion picture.

Classes IPC  ?

• G09G 3/20 - Dispositions ou circuits de commande présentant un intérêt uniquement pour l'affichage utilisant des moyens de visualisation autres que les tubes à rayons cathodiques pour la présentation d'un ensemble de plusieurs caractères, p. ex. d'une page, en composant l'ensemble par combinaison d'éléments individuels disposés en matrice
• G06T 3/40 - Changement d'échelle d’images complètes ou de parties d’image, p. ex. agrandissement ou rétrécissement
• H04N 5/262 - Circuits de studio, p. ex. pour mélanger, commuter, changer le caractère de l'image, pour d'autres effets spéciaux
• H04N 7/01 - Conversion des normes
• H04N 21/4402 - Traitement de flux élémentaires vidéo, p. ex. raccordement d'un clip vidéo récupéré d'un stockage local avec un flux vidéo en entrée ou rendu de scènes selon des graphes de scène du flux vidéo codé impliquant des opérations de reformatage de signaux vidéo pour la redistribution domestique, le stockage ou l'affichage en temps réel
• H03H 17/06 - Filtres non récursifs

Abrégé

A method for displaying an input frame on an edge-lit display lit by a multitude of light emitting diodes (LED) placed only along one or more sides of the display, comprises the steps of determining a brightness level for each LED of the multitude of LEDs, based on the input frame and an influence of each LED on the brightness of a pixel of the display, such that the brightness of the pixel essentially corresponds to the brightness level required by the input frame and an energy consumption of the LEDs and / or a difference between a resulting backlight and the input frame is essentially minimal, according to a given measure; dimming the light emitting diodes (LED), based on at least one input frame; and displaying the input frame on the display. According to the invention, a relation between at least two different LEDs of the multitude of LEDs, in particular between their respective brightness levels, is taken into account in the determination of the brightness levels.

Classes IPC  ?

• G09G 3/34 - Dispositions ou circuits de commande présentant un intérêt uniquement pour l'affichage utilisant des moyens de visualisation autres que les tubes à rayons cathodiques pour la présentation d'un ensemble de plusieurs caractères, p. ex. d'une page, en composant l'ensemble par combinaison d'éléments individuels disposés en matrice en commandant la lumière provenant d'une source indépendante

Abrégé

growing the production organism in the presence of a fermentable carbon source whereby one or more polyunsaturated fatty acids are produced, and optionally recovering the one or more polyunsaturated fatty acids.

Classes IPC  ?

• C12P 7/64 - GraissesHuilesCires de type esterAcides gras supérieurs, c.-à-d. ayant une chaîne continue d'au moins sept atomes de carbone liée à un groupe carboxyleHuiles ou graisses oxydées
• C12N 9/02 - Oxydoréductases (1.), p. ex. luciférase
• C12N 9/10 - Transférases (2.)
• C12N 15/52 - Gènes codant pour des enzymes ou des proenzymes

Abrégé

The invention relates to a method and an analyzing device for analyzing projection data (g) of an object (f) to be examined, said projection data being ascertained along a trajectory (φ) in multiple projection positions (λ) relative to a coordinate origin (O). A respective trajectory function is ascertained for each projection position (λ), wherein a distance (d) and a directional vector (r) relative to the coordinate origin (O) are determined for multiple positions (y) from a reconstruction region (Ω) of the dimension n; a dimension n-1 hyperplane (H), which runs perpendicular to the directional vector (r) and has the distance (d) to the coordinate origin (O), is determined; a number (s) of intersections (S) between the hyperplane (H) and the trajectory (φ) is determined; a derivation vector of the trajectory (φ) is determined according to the trajectory curve and calculated in the projection position (λ); and an absolute value of the scalar product between the derivation vector and the position (y) is determined and divided by the number (s). The ascertained trajectory functions are transformed into a frequency domain of the dimension n, and the projection data (g) is analyzed using the transformed trajectory functions.

Classes IPC  ?

• G06T 11/00 - Génération d'images bidimensionnelles [2D]

Abrégé

The invention provides novel cyclodextrin compounds. Specifically, the invention relates to cyclodextrin derivatives with thioether groups at the primary hydroxy I positions and various substituents at the secondary hydroxy I groups. The invented cyclodextrin compounds are preferably water-soluble, show high binding potential of active ingredients and do not form micelles in water. Therefore, said compounds are envisaged for complexation and eventually solubilization of a variety of active agents, including pharmaceutically active ingredients. The invention further provides a method for preparing the inventive cyclodextrin compounds as well as composition comprising the cyclodextrin compounds of the invention.

Classes IPC  ?

• C08B 37/16 - CyclodextrineSes dérivés

Abrégé

The invention relates to methods for diagnosing Parkinson's Disease PAD) with miRNA markers. Towards the identification of biomarkers for diagnosis of PD, a comprehensive analysis of miRNA expression patterns was obtained. Significantly deregulated miRNAs were identified.

Classes IPC  ?

• C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
• G01N 33/567 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet utilisant un support spécifique ou des protéines réceptrices comme réactifs pour la formation de liaisons par ligand utilisant un extrait de tissu ou d'organe comme agent de liaison
• C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
• G06F 19/20 - pour l'hybridation ou l'expression génique, p.ex. microréseaux, séquençage par hybridation, normalisation, profilage, modèles de correction de bruit, estimation du ratio d'expression, conception ou optimisation de sonde
• G06F 19/00 - Équipement ou méthodes de traitement de données ou de calcul numérique, spécialement adaptés à des applications spécifiques (spécialement adaptés à des fonctions spécifiques G06F 17/00;systèmes ou méthodes de traitement de données spécialement adaptés à des fins administratives, commerciales, financières, de gestion, de surveillance ou de prévision G06Q;informatique médicale G16H)
• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux

Abrégé

A method for compensating Doppler shifts (v) in a mobile communication system comprises the steps of: - receiving a mobile communication signal (y); - transforming the signal in order to compensate a Doppler shift (vp) of at least one propagation path (p) of the signal (y); and - outputting the compensated signal. A matching pursuit (MP) algorithm is used for estimating Doppler shifts of propagation paths (p) of the signal.

Classes IPC  ?

• H04L 25/02 - Systèmes à bande de base Détails
• H04L 25/03 - Réseaux de mise en forme pour émetteur ou récepteur, p. ex. réseaux de mise en forme adaptatifs

Abrégé

A method for compensating Doppler shifts (v) in a mobile communication system comprises the steps of: receiving a mobile communication signal (y); transforming the signal in order to compensate a Doppler shift (vp) of at least one propagation path (p) of the signal (y); and outputting the compensated signal. A matching pursuit (MP) algorithm is used for estimating Doppler shifts of propagation paths (p) of the signal.

Classes IPC  ?

• H04L 27/00 - Systèmes à porteuse modulée

Abrégé

A method for displaying pixels on display devices, comprising the steps of (a) Providing virtual pixel storage means, preferably one or more virtual frame buffers (6), for temporarily storing the pixel data, (b) Receiving pixel data into the virtual pixel storage means (6) from one or more pixel sources (5), (c) Processing the pixel data stored in the virtual pixel storage means, based on characteristic display parameters characterizing the display devices; and (d) Transmitting the pixel data from the virtual pixel storage means (6) to one or more virtual displays attached to the virtual pixel storage means via a network (7), based on a network transmission protocol. The invention further relates to a system for displaying pixels on display devices.

Classes IPC  ?

• G09G 5/00 - Dispositions ou circuits de commande de l'affichage communs à l'affichage utilisant des tubes à rayons cathodiques et à l'affichage utilisant d'autres moyens de visualisation
• G09G 5/12 - Synchronisation entre l'unité d'affichage et d'autres unités, p. ex. d'autres unités d'affichage, des lecteurs de disques vidéo
• G06F 3/14 - Sortie numérique vers un dispositif de visualisation
• G09G 5/04 - Dispositions ou circuits de commande de l'affichage communs à l'affichage utilisant des tubes à rayons cathodiques et à l'affichage utilisant d'autres moyens de visualisation caractérisés par la manière dont la couleur est visualisée utilisant des circuits comme interface avec l'affichage en couleurs