Abstract

xy2z∞233 -33 2-33H-, and –Cl and optionally also substituted at least once by -COO-; where y is 1 to 3; and where z is 0 to 10.

IPC Classes  ?

• G01K 3/04 - Thermometers giving results other than momentary value of temperature giving mean valuesThermometers giving results other than momentary value of temperature giving integrated values in respect of time
• C09K 11/02 - Use of particular materials as binders, particle coatings or suspension media therefor
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
• G01K 11/20 - Measuring temperature based on physical or chemical changes not covered by group , , , or using thermoluminescent materials

Abstract

The present invention relates to a redox flow battery comprising: a first compartment comprising a negolyte in the form of an aqueous composition comprising at least one compound of formula (I) The present invention relates to a redox flow battery comprising: a first compartment comprising a negolyte in the form of an aqueous composition comprising at least one compound of formula (I) and/or a salt of the compound of formula (I), and/or a reduced form of the compound of formula (I), wherein X1, X2, X3, X4, X5, X6, X7 and X8 are independently chosen from the group consisting of a hydrogen atom, a halogen, an ether group of formula —O-A, an OH group, COOH group, -A-COOH group, —O-A-COOH group and a linear, cyclic, or branched, saturated or unsaturated hydrocarbon group comprising from 1 to 10 carbon atoms, A representing a linear, cyclic or branched, saturated or unsaturated hydrocarbon group comprising 1 to 10 carbon atoms, wherein at least one of X1, X2, X3, X4, X5, X6, X7 and X8 comprises an OH or COOH functional group; a second compartment comprising a posolyte in the form of an aqueous composition, comprising at least one electroactive molecule for example ferrocyanide ions [Fe(CN)6]4− and/or ferricyanide ions [Fe(CN)6]3−, the negolyte additionally comprising at least one solubilising base, the solubilising base being characterised in that the pKa of the conjugate acid of the solubilising base is higher than 9.5 in water at 25° C. and in that the volume of the cation of the solubilising base is between 14 and 650 cubic Angstroms.

IPC Classes  ?

• H01M 8/18 - Regenerative fuel cells, e.g. redox flow batteries or secondary fuel cells

Abstract

Method for operando characterization of the chemical composition of a battery cell, comprising the following steps: inserting an optical fiber made of chalcogenide glass through the battery cell, cycling the battery, while cycling the battery, generating an optical signal and transmitting it through the optical fiber, detecting, using an infrared spectrometer, the transmitted optical signal at an output extremity of the optical fiber, recording the detected optical signal over time, locating, using fiber evanescent wave spectroscopy, signature wavelengths for which the optical signal intensity is above a predetermined threshold within the spectrum, associating the located signature wavelengths to at least one predetermined chemical species.

IPC Classes  ?

• G01N 21/25 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
• G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
• G01N 21/35 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
• G01N 21/3563 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing solidsPreparation of samples therefor
• H01M 10/48 - Accumulators combined with arrangements for measuring, testing or indicating the condition of cells, e.g. the level or density of the electrolyte

Abstract

Elementary cell for electrolysis, the elementary anode having a channel for bubbles of a first gas, the elementary cathode having a channel for bubbles of a second gas, wherein the elementary anode and/or the elementary cathode extend locally into the elementary main channel near the mouth, along a downstream portion of the mouth in an average direction of the elementary main channel.

IPC Classes  ?

• C25B 11/03 - ElectrodesManufacture thereof not otherwise provided for characterised by shape or form perforated or foraminous
• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• C25B 9/07 - Common duct cells
• C25B 9/13 - Single electrolytic cells with circulation of an electrolyte

Abstract

The invention relates to an antenna array system (1) comprising: a main powered antenna (30) which is configured to emit a beam directed in a plurality of main directions, the main powered antenna operating in a first frequency band; a set of parasitic antennas (10.1, 10.2, 10.3, 10.4) which are arranged so as to form a first envelope by concentrically surrounding the main powered antenna (30), each antenna comprising a substrate (13.1, 13.2, 13.3, 13.4) which is made of dielectric material, has a face oriented towards the outside of the envelope and provided with a parasitic radiating element (11.1, 11.2, 11.3, 11.4), and is provided with a ground plane, the parasitic radiating element (11.1, 11.2, 11.3, 11.4) being connected to the ground plane via a reactive load (12.1, 12.2, 12.3, 12.4), each parasitic antenna being configured to emit a beam directed in a main direction, the reactive loads (12.1, 12.2, 12.3, 12.4) being configured to selectively activate electromagnetic coupling between the main powered antenna and a pair of parasitic antennas in order to modify the directivity of the main powered antenna.

IPC Classes  ?

• H01Q 3/44 - Arrangements for changing or varying the orientation or the shape of the directional pattern of the waves radiated from an antenna or antenna system varying the electric or magnetic characteristics of reflecting, refracting, or diffracting devices associated with the radiating element
• H01Q 5/40 - Imbricated or interleaved structuresCombined or electromagnetically coupled arrangements, e.g. comprising two or more non-connected fed radiating elements
• H01Q 9/36 - Vertical arrangement of element with top loading
• H01Q 21/06 - Arrays of individually energised antenna units similarly polarised and spaced apart

Abstract

The present invention relates to an iminium salt having the following formula (I) and also to a ruthenium complex having the following formula (II): The present invention relates to an iminium salt having the following formula (I) and also to a ruthenium complex having the following formula (II): The present invention relates to an iminium salt having the following formula (I) and also to a ruthenium complex having the following formula (II): as well as the use of said ruthenium complex as catalyst, in particular in olefin metathesis.

IPC Classes  ?

• C07D 209/56 - Ring systems containing three or more rings
• B01J 31/22 - Organic complexes
• C07D 209/96 - Spiro-condensed ring systems
• C07F 7/08 - Compounds having one or more C—Si linkages
• C07F 7/18 - Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
• C07F 15/00 - Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table

Abstract

The invention relates to a microwave sensor (2) for detecting at least one target gas, the sensor comprising: a substrate (4); a microwave device (5) printed on the substrate (4) and having a deposition opening (7); and a liquid substance (8) sensitive to the at least one target gas, the liquid substance (8) being arranged in the deposition opening (7) so as to be in contact with the microwave device (5), the liquid substance (8) being a deep eutectic solvent and chosen such that the presence of the at least one target gas causes at least one of a change in the dielectric characteristics or a change in the electrical characteristics of the liquid substance (8), resulting in a change in the distribution parameters of the microwave device (5).

IPC Classes  ?

• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
• G01N 22/00 - Investigating or analysing materials by the use of microwaves or radio waves, i.e. electromagnetic waves with a wavelength of one millimetre or more

Abstract

The present invention thus provides a novel family of liposomal compositions (nanocarriers), hereinafter referred to as Tetra-Acidosomes, comprising natural tetrameric acid (TA) lipids and/or novel chemically functionalized tetrameric acid (CFTA) lipids, for drug delivery applications.

IPC Classes  ?

• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• C07C 69/608 - Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a ring other than a six-membered aromatic ring in the acid moiety
• C07C 219/10 - Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to an acyclic carbon atom of a carbon skeleton containing rings
• C07D 249/04 - 1,2,3-TriazolesHydrogenated 1,2,3-triazoles
• C08G 65/00 - Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule

Abstract

The inventors have succeeded in developing urea, amide or sulfonamide compounds, in particular urea compounds, bearing two side groups, one of which carries a dialkylaryl moiety, in particular a dialkylphenyl or dialkylpyridinyl moiety. These compounds have the advantage of inhibiting IRE1 RNase activity and sensitizing cancer cells, in particular GB cells, to chemotherapy. The present invention relates to urea, amide or sulfonamide compounds, in particular urea compounds, bearing two side groups, one of which carries a dialkylaryl moiety, in particular a dialkylphenyl or dialkylpyridinyl moiety, including their pharmaceutically acceptable salts and solvates which are useful as sensitizers for chemotherapy of cancer cells, particularly in glioblastoma, and are useful as therapeutic compounds, particularly in the treatment of cancers that may be treated by alkylating agents, such as temozolomide.

IPC Classes  ?

• C07D 215/06 - Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
• C07C 275/28 - Derivatives of urea, i.e. compounds containing any of the groups the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
• C07C 311/13 - Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
• C07D 215/227 - Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
• C07D 231/56 - BenzopyrazolesHydrogenated benzopyrazoles
• C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 471/04 - Ortho-condensed systems
• A61P 35/00 - Antineoplastic agents
• A61K 31/17 - Amides, e.g. hydroxamic acids having the group N—C(O)—N or N—C(S)—N, e.g. urea, thiourea, carmustine
• A61K 31/145 - Amines, e.g. amantadine having sulfur atoms, e.g. thiurams (N—C(S)—S—C(S)—N or N—C(S)—S—S—C(S)—N)Sulfinylamines (—N=SO)Sulfonylamines (—N=SO2)
• A61K 31/407 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with heterocyclic ring systems, e.g. ketorolac, physostigmine

Abstract

The present invention relates to a catalyst composition comprising: catalyst component A comprising the meso form of a bridged metallocene compound with two indenyl groups, each indenyl being independently substituted with one or more substituents, wherein at least one of the substituents is on position 3 and/or 5 of each indenyl, and wherein at least one of the substituents is an aryl or heteroaryl; wherein the meso/rac ratio of the meso form of the bridged metallocene compound of catalyst component A is 95:5 or greater, as determined using 1H NMR; preferably wherein the aryl or heteroaryl substituent is on the 3-position of each indenyl; catalyst component B comprising a bridged metallocene compound with two indenyl groups, each indenyl being independently substituted with one or more substituents, wherein at least one of the substituents is an unsubstituted or substituted aryl or heteroaryl; and wherein the unsubstituted or substituted aryl or heteroaryl is not on position 3 and/or 5 of the indenyl; and an optional activator; an optional support; and an optional co-catalyst. The present invention also relates to a polymerization process using said composition. The invention further relates to olefin polymers at least partially catalyzed by said catalyst composition and articles comprising said olefin polymers.

IPC Classes  ?

• C08F 10/02 - Ethene

Abstract

A self-adaptive shielding device is suitable for a lens or a window of a piece of equipment provided with an electrically conductive enclosure containing an optical or RF sensor. The device includes a shielding screen having a switchable RF shielding mesh of micrometric pitch at least partially surrounded by a border of insulator-metal transition material arranged between the mesh and an electrically conductive envelope. A susceptor element is arranged facing the insulator-metal transition material and transforms incident electromagnetic energy (RFH) into activation heat for the insulator-metal transition material. The susceptor element causes a transition to the conductive state of the insulator-metal transition material under the action of the electromagnetic energy so as to electrically connect the mesh to the electrically conductive envelope when the incident electromagnetic energy exceeds a given threshold.

IPC Classes  ?

• H05K 9/00 - Screening of apparatus or components against electric or magnetic fields

Abstract

The present invention relates to a method for the electrosynthesis of substituted 1,4-naphthoquinones in an electrolytic cell, and to a method for the synthesis of substituted 1,4-naphthoquinones in a flow fuel cell. The present invention also relates to the use of said substituted 1,4-naphthoquinones as a redox molecule in the negolyte of a redox flow battery. Lastly, the present invention relates to a redox flow battery comprising a posolyte comprising a redox molecule and a negolyte comprising at least one substituted 1,4-naphthoquinone obtained by one of the methods according to the invention.

IPC Classes  ?

• C25B 3/07 - Oxygen containing compounds
• C25B 3/23 - Oxidation
• C25B 15/08 - Supplying or removing reactants or electrolytesRegeneration of electrolytes
• H01M 8/18 - Regenerative fuel cells, e.g. redox flow batteries or secondary fuel cells
• C07C 46/00 - Preparation of quinones

Abstract

The tumor microenvironment (TME) is characterized by hostile conditions that lead to the induction of the unfolded protein response (UPR) in both cancer cells and immune infiltrating cells. Mechanistically, DPM1 KO leads to reduced production of key cytokines and cell surface expression of PD-L1 (a major player in the control of adaptive immune response) through ERAD (ER-associated protein degradation). Additionally, DPM1 KO in cancer cells limited M2-like macrophages polarization overcoming immunosuppression and enhances cytotoxic T cell activity. Thus, the inventors' work reveals how tumoral UPR can limit tumor growth and suggests that DPM1 inhibition is a useful strategy for improving cancer immunotherapy. The present invention relates to a method of treating cancer in a patient in need thereof comprising administering to the patient a therapeutically effective amount of a Dolichol-phosphate mannosyltransferase (DPM1) inhibitor.

IPC Classes  ?

• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61K 31/00 - Medicinal preparations containing organic active ingredients
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 35/00 - Antineoplastic agents
• A61K 38/00 - Medicinal preparations containing peptides
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The present invention relates to a catalyst composition comprising: catalyst component A comprising the meso form of a bridged metallocene compound with two indenyl groups, each indenyl being substituted with one or more substituents, wherein at least one of the substituents is an aryl or heteroaryl; wherein the meso/rac ratio of the meso form of the bridged metallocene compound of catalyst component A is 95:5 or greater; catalyst component B comprising a bridged metallocene compound with a substituted or unsubstituted cyclopentadienyl group and a substituted or unsubstituted fluorenyl group; and an optional activator; an optional support; and an optional co-catalyst. The present invention also relates to a polymerization process using said composition. The invention further relates to olefin polymers at least partially catalyzed by said catalyst composition and articles comprising said olefin polymers. The present invention also relates to a metallocene-catalyzed ethylene polymer having: a melt index MI2 ranging from 0.1 g/10 min to 12.0 g/10 min wherein MI2 is determined according to ISO 1133:2005 Method B, condition D, at a temperature 190° C. and a 2.16 kg load using a die of 2.096 mm; a molecular weight distribution Mw/Mn, ranging from 4.0 to 12.0, with Mw being the weight-average molecular weight and Mn being the number-average molecular weight; a rheology long chain branching index grheo of at least 0.90, preferably at least 0.93, preferably at least 0.95; and preferably at least 0.30% by weight of ethyl branching with regard to the total weight of the ethylene polymer measured by 13C NMR, with the proviso that said ethyl branching is not generated from 1-butene incorporation as comonomer.

IPC Classes  ?

• C08F 10/02 - Ethene

Abstract

A device for measuring a physical quantity related to an electromagnetic field emitted by an electromagnetic source. The device is configured to simulate the electromagnetic characteristics of a reference object made of a lossy medium, e.g. a biological tissue. The device includes: a dielectric layer including an upper surface faced to the electromagnetic source and a bottom surface, the dielectric layer being at least partly transparent to the electromagnetic field emitted by the electromagnetic source; an electromagnetic field enhancing element arranged relative to the dielectric layer and configured in a manner to enhance the intensity of the electromagnetic field transmitted through the dielectric layer in a pre-determined zone; and a sensor arranged beneath the electromagnetic field enhancing element and configured to measure the physical quantity related to the electromagnetic field transmitted through the dielectric layer and the electromagnetic field enhancing element.

IPC Classes  ?

• G01R 29/08 - Measuring electromagnetic field characteristics

Abstract

The present invention relates to a passive photoelectrochemical electrochemiluminescent device, systems and methods comprising a photovoltaic element and two electrodes.

IPC Classes  ?

• G01N 21/69 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence specially adapted for fluids
• G01N 21/76 - ChemiluminescenceBioluminescence
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
• H01L 31/14 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof structurally associated with, e.g. formed in or on a common substrate with, one or more electric light sources, e.g. electroluminescent light sources, and electrically or optically coupled thereto the light source or sources being controlled by the semiconductor device sensitive to radiation, e.g. image converters, image amplifiers or image storage devices

Abstract

PIM2 kinase deregulation has been reported in several cancers. In particular, PIM2 is considered in multiple myeloma as part of the oncogenic process and several PIM kinase inhibitors have been developed showing encouraging results in preclinical studies and clinical trials. Now the inventors have developed an antisense RNA strategy based on a splice-switching oligonucleotide (SSO) so as to induce efficient knockdown of PIM2 expression. This SSO-mediated knockdown is a powerful approach to for cancer treatments. Accordingly, the present invention relates to the use of splice switching oligonucleotides for exon skipping-mediated knockdown of PIM2.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

The present invention relates to a process for the preparation of an optically pure (+) or (−) enantiomer of an iminium salt having the formula (I), aid process comprising the following steps: a) a reduction step of an iminium salt having the formula (II), said salt being in the form of a racemic mixture, in order to obtain a compound having the formula (III) in the form of a racemic mixture, b) a step of chiral HPLC separation of the compound of formula (III) in the form of a racemic mixture, for obtaining an optically pure (+) or (−) enantiomer compound having the formula (IV), and c) an oxidation step of the compound of formula (IV) for obtaining the compound of formula (I).

IPC Classes  ?

• C07D 207/20 - Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
• B01J 31/22 - Organic complexes
• C07D 471/08 - Bridged systems
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
• H10K 85/30 - Coordination compounds

Abstract

The invention relates to a device (1) which comprises an active electromechanical layer made of a semiconductor material (40), with two polymers, at least one of which is conjugated, arranged between two metal electrodes (2a, 2b) so as to be capable of generating a voltage between the two electrodes (2a, 2b) when the device is folded. The electromechanical layer (4) has a thickness of between 10 and 160 micrometres, at least one of the two electrodes (2a, 2b) being directly bonded to this layer. The electrodes are configured to be flexible and less thick than the active electromechanical layer within a multilayer structure of the device. The conductive polymer PEDOT may be one of the conjugated polymers. The flexoelectric device (1) obtained, protected if necessary in a protective assembly (7) by a flexible encapsulation material of submillimetric thickness, can be used in the form of a band in a sensor (C) for detecting a curvature or a position of an object.

IPC Classes  ?

• G01B 1/00 - Measuring instruments characterised by the selection of material therefor
• G01B 7/16 - Measuring arrangements characterised by the use of electric or magnetic techniques for measuring the deformation in a solid, e.g. by resistance strain gauge
• G01L 1/00 - Measuring force or stress, in general
• H10N 30/30 - Piezoelectric or electrostrictive devices with mechanical input and electrical output, e.g. functioning as generators or sensors
• H10N 30/077 - Forming of piezoelectric or electrostrictive parts or bodies on an electrical element or another base by depositing piezoelectric or electrostrictive layers, e.g. aerosol or screen printing by liquid phase deposition
• H10N 30/098 - Forming organic materials
• H10N 30/857 - Macromolecular compositions

Abstract

Process for the hydrochlorination of alkenes, comprising the following steps: a)- preparing an organic solution A of a compound (I) comprising at least one alkene function by dissolving it potentially in an organic solvent; b)- mixing the solution A with a aqueous solution B comprising hydrochloric acid; c)- stirring the mixture comprising solution A and solution B at stirring speed of at least 500 rpm, and at a temperature in the range from -5 to 105°C for at least half an hour.

IPC Classes  ?

• C07C 17/08 - Preparation of halogenated hydrocarbons by addition of hydrogen halides to unsaturated hydrocarbons
• C07C 29/62 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by introduction of halogenPreparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by substitution of halogen atoms by other halogen atoms
• C07C 41/22 - Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of halogenPreparation of ethers by reactions not forming ether-oxygen bonds by substitution of halogen atoms by other halogen atoms
• C07C 45/63 - Preparation of compounds having C=O groups bound only to carbon or hydrogen atomsPreparation of chelates of such compounds by reactions not involving the formation of C=O groups by introduction of halogenPreparation of compounds having C=O groups bound only to carbon or hydrogen atomsPreparation of chelates of such compounds by reactions not involving the formation of C=O groups by substitution of halogen atoms by other halogen atoms
• C07C 51/363 - Preparation of carboxylic acids or their salts, halides, or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogenPreparation of carboxylic acids or their salts, halides, or anhydrides by reactions not involving formation of carboxyl groups by substitution of halogen atoms by other halogen atoms
• C07C 67/287 - Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group by introduction of halogenPreparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group by substitution of halogen atoms by other halogen atoms
• C07C 253/30 - Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
• C07D 209/48 - Iso-indolesHydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide

Abstract

The invention relates to a method for inhibiting the nitrification process in soil, wherein one or more miRNAs are applied to the soil in order to inhibit the expression of one or more genes participating in the nitrification process in said soil, such as the genes encoding the AMO (ammonia monooxygenase) enzyme and/or the HAO (hydroxylamine oxidoreductase) enzyme.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 9/06 - Oxidoreductases (1.), e.g. luciferase acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7)
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C05G 3/00 - Mixtures of one or more fertilisers with additives not having a specifically fertilising activity
• C05G 3/90 - Mixtures of one or more fertilisers with additives not having a specifically fertilising activity for affecting the nitrification of ammonium compounds or urea in the soil
• C05G 3/60 - Biocides or preservatives, e.g. disinfectants, pesticides or herbicidesPest repellants or attractants

Abstract

Intrahepatic cholangiocarcinoma (iCCA) is a deadly cancer worldwide with an increasing incidence and limited therapeutic options. Therefore, there is an urgent need to open the field to new concepts for identifying clinically relevant therapeutic targets and biomarkers. Here, the inventors explored the role and the clinical relevance of circular RNA circLTBP2 in iCCA. In particular, CircLTBP2 (hsa_circ_0032603) was identified as a novel TGFβ-induced circRNA in several CCA cell lines. CircLTBP2 promotes tumor cell proliferation, migration and resistance to gemcitabine-induced apoptosis in vitro and tumor growth in vivo. Mechanistically, circLTBP2 acts as a competitive RNA regulating notably the activity of the tumor suppressor microRNA miR-338-3p, leading to the overexpression of its pro-metastatic targets. The restoration of miR-338-3p levels in iCCA cells reversed the pro-tumorigenic effects driven by circLTBP2, including the resistance to gemcitabine-induced apoptosis. In addition, circLTBP2 expression predicted a reduced survival, as detected in tumor tissues but also in serum exosomes isolated from patients with iCCA. In conclusion, CircLTBP2 is a novel effector of the pro-tumorigenic arm of TGFβ and a clinically relevant biomarker easily detected from liquid biopsies in iCCA. Thus, the present invention relates to the circulating RNA circLTBP2 as a biomarker and biotarget in intrahepatic cholangiocarcinomas.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

The present invention provides a method for depositing a film onto the surface of a complex three-dimensional substrate, while avoiding the fracturing and drawbacks observed in the prior art, resulting in a consistent deposition of the conductive film onto a substrate.

IPC Classes  ?

• B82Y 40/00 - Manufacture or treatment of nanostructures
• H05K 3/20 - Apparatus or processes for manufacturing printed circuits in which conductive material is applied to the insulating support in such a manner as to form the desired conductive pattern by affixing prefabricated conductor pattern
• H05K 3/22 - Secondary treatment of printed circuits

Abstract

CAMexpPP; - a pulsed light source (4) capable of generating light pulses that are intended to illuminate a measurement zone of the sample; - a synchronisation unit (5) configured to synchronise the emission of each light pulse with the exposure time of the camera according to a series of light pulses; - a unit for defining a series of light pulses (6) in order to define an increasing sequence of time intervals between two pulses; - an image construction unit (7) configured to construct a set of pairs of images in order to define an increasing sequence of time intervals between two images.

IPC Classes  ?

• H04N 23/74 - Circuitry for compensating brightness variation in the scene by influencing the scene brightness using illuminating means
• H04N 23/56 - Cameras or camera modules comprising electronic image sensorsControl thereof provided with illuminating means
• H04N 23/73 - Circuitry for compensating brightness variation in the scene by influencing the exposure time
• G01N 15/02 - Investigating particle size or size distribution
• G02B 21/00 - Microscopes
• G01N 15/14 - Optical investigation techniques, e.g. flow cytometry
• G01N 15/1433 - Signal processing using image recognition
• G01N 15/1434 - Optical arrangements
• G01N 15/10 - Investigating individual particles

Abstract

Antenna includes at least one first resonant cavity and a second resonant cavity, each resonant cavity being closed by a base at one end and including a radiating element superimposed on the base of the resonant cavity, the radiating element of the first cavity being able to transmit a signal on a first frequency band and the radiating element of the second cavity being able to transmit a signal on a second frequency band separate from the first frequency band, characterized in that a first distance between the base and radiating element of the first cavity differs from a second distance between the base and radiating element of the second cavity.

IPC Classes  ?

• H01Q 5/30 - Arrangements for providing operation on different wavebands
• H01Q 1/28 - Adaptation for use in or on aircraft, missiles, satellites, or balloons

Abstract

The present invention pertains to a method for the prognosis or clear cell renal cell carcinoma (ccRCC) based on cell clusters identified by deconvolution of a single-cell malignancy atlas. The present inventors have designed and validated a scRNA-seq protocol to characterize the malignant cells (MC) in ccRCC tumors from ccRCC patients. By applying an in silico deconvolution approach 5 to a bulk RNA-seq dataset of ccRCCs, the present inventors have shown that the predicted proportion of specific cells clusters were strongly associated with specific prognoses and notably allow for the accurate stratification of patients. The markers identified by the present inventors particularly allow identifying high-grade patients who would have erroneously been classified as low- grade according to the current classification system.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

A dual-band analogue filter that is passing for IFF signals and ADS-B signals in a first and a second frequency band, and to reject signals received outside these bands, implemented using multi-planar technology, and comprising, in succession: a layer comprising an input port and an output port, a layer comprising a ground plane having openings facing the input port and the output port, a layer comprising N band-pass resonators, a layer comprising N band-stop resonators, arranged such that: the band-pass resonators are connected in pairs by coupling, the first and the last band-pass resonator are connected to the input port and the output port by electromagnetic coupling, each band-pass resonator is connected to a band-stop resonator by electromagnetic coupling.

IPC Classes  ?

• H04B 1/00 - Details of transmission systems, not covered by a single one of groups Details of transmission systems not characterised by the medium used for transmission
• H01P 1/203 - Strip line filters

Abstract

The present invention relates to a catalyst of Formula (I) wherein R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, L1, M1, Q1 and Q2 have the meaning defined in the description and claims. The present invention also relates to a catalyst composition comprising at least one catalyst according to the invention. an optional activator: an optional support: and an optional co-catalyst. The present invention also relates to the use of a catalyst or catalyst composition according to the invention for the preparation of an olefin polymer. The present invention also relates to an olefin polymerization process. the process comprising: contacting a catalyst or a catalyst composition according to the invention, with an olefin monomer, optionally hydrogen, and optionally one or more olefin comonomers: polymerizing the monomer, and the optionally one or more olefin comonomers, in the presence of the at least one catalyst composition, and optional hydrogen, thereby obtaining an olefin polymer. The present invention also relates to olefin polymers and articles comprising said olefin polymer. The present invention relates to a catalyst of Formula (I) wherein R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, L1, M1, Q1 and Q2 have the meaning defined in the description and claims. The present invention also relates to a catalyst composition comprising at least one catalyst according to the invention. an optional activator: an optional support: and an optional co-catalyst. The present invention also relates to the use of a catalyst or catalyst composition according to the invention for the preparation of an olefin polymer. The present invention also relates to an olefin polymerization process. the process comprising: contacting a catalyst or a catalyst composition according to the invention, with an olefin monomer, optionally hydrogen, and optionally one or more olefin comonomers: polymerizing the monomer, and the optionally one or more olefin comonomers, in the presence of the at least one catalyst composition, and optional hydrogen, thereby obtaining an olefin polymer. The present invention also relates to olefin polymers and articles comprising said olefin polymer.

IPC Classes  ?

• C08F 4/76 - MetalsMetal hydridesMetallo-organic compoundsUse thereof as catalyst precursors selected from metals not provided for in group selected from refractory metals selected from titanium, zirconium, hafnium, vanadium, niobium, or tantalum
• C08F 2/06 - Organic solvent
• C08F 210/06 - Propene

Abstract

Wide-angle impedance-matching device (102) for a radiating-element array antenna, comprising:- a transmission screen (103) having a first surface intended to be positioned facing the radiating-element array parallel to the radiating aperture of the antenna and being configured to match the impedance of the antenna for an H-plane scan,- and a set of metal pins (104) placed orthogonally, on at least one surface of the transmission screen (103), at the intersection of at least some of the respective anti-symmetry planes of the electric field radiated by the antenna for an H-plane scan, for two linear polarizations in two orthogonal directions, said set of metal pins (104) being configured to match the impedance of the antenna for an E-plane scan.

IPC Classes  ?

• H01Q 1/38 - Structural form of radiating elements, e.g. cone, spiral, umbrella formed by a conductive layer on an insulating support
• H01Q 9/04 - Resonant antennas
• H01Q 15/24 - Polarising devicesPolarisation filters
• H01Q 21/06 - Arrays of individually energised antenna units similarly polarised and spaced apart
• H01Q 21/29 - Combinations of different interacting antenna units for giving a desired directional characteristic
• H03H 7/38 - Impedance-matching networks

Abstract

The present invention relates to an optically pure (+) or (−) enantiomer of a ruthenium complex having formula (I) as well as the preparation method of said enantiomer, and uses thereof as catalyst, in particular in asymmetric olefin metathesis.

IPC Classes  ?

• B01J 31/22 - Organic complexes
• B01J 37/00 - Processes, in general, for preparing catalystsProcesses, in general, for activation of catalysts
• C07C 6/04 - Metathesis reactions at an unsaturated carbon-to-carbon bond at a carbon-to-carbon double bond
• C07F 15/00 - Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table

Abstract

A method of manufacturing a composite material including at least one ply integrating at least one electronic element situated at the surface of the ply. Also, materials obtained thereof and devices including such materials. The method includes: a) preparing or providing a first substrate having at least one layer; b) applying at least one electronic element onto a face of the first substrate; c) at least partially impregnating the so-obtained product within an impregnation material to form a matrix incorporating the at least one electronic element and the first substrate; d) preparing or providing an impregnable second substrate, the second substrate being placed on top of the impregnated at least one electronic element so that the at least one electronic element is interposed between the first substrate and the second substrate; e) removing the first substrate from the impregnated product obtained; and f) recovering the composite material.

IPC Classes  ?

• B29C 70/86 - Incorporating in coherent impregnated reinforcing layers
• B29C 70/54 - Component parts, details or accessoriesAuxiliary operations
• B29L 31/34 - Electrical apparatus, e.g. sparking plugs or parts thereof

Abstract

The present invention relates to relates to a pharmaceutical composition comprising a combination of N-acetylcysteine with at least one inhibitor of regulated necrotic cell death, such as necroptosis and/or ferroptosis.

IPC Classes  ?

• A61K 31/16 - Amides, e.g. hydroxamic acids
• A61K 31/198 - Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
• A61K 31/353 - 3,4-Dihydrobenzopyrans, e.g. chroman, catechin
• A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 17/18 - Antioxidants, e.g. antiradicals

Abstract

The present invention relates to the use of a compound of formula (I) as a catalyst for the oxidation of an olefin into a ketone and to a process of oxidation of an olefin into a ketone comprising a step (a) of reacting said olefin with an oxidant in the presence of a catalyst of formula (I).

IPC Classes  ?

• C07C 45/36 - Preparation of compounds having C=O groups bound only to carbon or hydrogen atomsPreparation of chelates of such compounds by oxidation with molecular oxygen of CHx-moieties in unsaturated compounds in compounds containing six-membered aromatic rings
• C07C 49/76 - Ketones containing a keto group bound to a six-membered aromatic ring
• B01J 31/18 - Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony

Abstract

The invention relates to the field of diagnosing steatohepatitis, in particular alcoholic steatohepatitis. By following studies on a cohort of nearly 200 patients, the inventors showed that four or five specific, readily available markers, when combined in a function, make it possible, by themselves, to highly accurately diagnose steatohepatitis at the early stages of the disease, when the subject is still asymptomatic. In particular, the invention relates to a non-invasive, highly performant method of diagnosing steatohepatitis in a subject, which combines in a function the values of the age, the blood concentration of cytokeratin 18 and at least two of: the body mass index, the blood concentration of α-2-macroglobulin and a data representative of liver stiffness as obtained by an ex vivo imaging technique. The method of the invention makes it possible to identify asymptomatic patients that may then benefit from potential therapeutics and/or be motivated to reduce alcohol consumption.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

A device for controlling radiofrequency beams comprising a set of cells. Each cell comprises a support frame and an excitation element, and emits and/or receives beams in an invariant manner according to the direction of propagation of the beam. The frame is inscribed within a generally tubular shape, oriented along the axis Z of a reference frame, having a cross section of perimeter P, and comprises an entrance, an exit and a number N of slots between the exit and a position Zo located between the entrance and the exit. Each slot has a variable width along Z. The slot width has a minimum value at the position Zo, and a maximum value at the exit that is determined on the basis of the perimeter P and the number N.

IPC Classes  ?

• H01Q 13/08 - Radiating ends of two-conductor microwave transmission lines, e.g. of coaxial lines, of microstrip lines
• H04B 7/06 - Diversity systemsMulti-antenna systems, i.e. transmission or reception using multiple antennas using two or more spaced independent antennas at the transmitting station

Abstract

The invention proposes a device (10) for controlling radiofrequency beams comprising a set of cells (100). Each cell comprises a support frame (130) and an excitation element (150), and emits and/or receives beams in an invariant manner according to the direction of propagation of the beam. The frame is inscribed within a generally tubular shape, oriented along the axis Z of a reference frame (X,Y,Z), having a cross section of perimeter P, and comprises an entrance (131), an exit (132) and a number N of slots (133-n) between the exit and a position Zo located between the entrance and the exit. Each slot has a variable width along Z. The slot width has a minimum value at the position Zo, and a maximum value at the exit that is determined on the basis of the perimeter P and the number N.

IPC Classes  ?

• B33Y 10/00 - Processes of additive manufacturing
• H01Q 1/12 - SupportsMounting means
• H01Q 1/36 - Structural form of radiating elements, e.g. cone, spiral, umbrella
• H01Q 3/26 - Arrangements for changing or varying the orientation or the shape of the directional pattern of the waves radiated from an antenna or antenna system varying the relative phase or relative amplitude of energisation between two or more active radiating elementsArrangements for changing or varying the orientation or the shape of the directional pattern of the waves radiated from an antenna or antenna system varying the distribution of energy across a radiating aperture
• H01Q 21/29 - Combinations of different interacting antenna units for giving a desired directional characteristic

Abstract

A system for controlling the activation/deactivation of an electromagnetic shielding screen of a porthole or a protective window of an optoelectronic equipment, which includes, a radiofrequency electromagnetic sensor, with a bandwidth adapted to a cut-off band of said shielding screen corresponding to a range of electromagnetic fields to be blocked, connected to a detector-rectifier with a sensitivity higher than a minimum value of the power of an electromagnetic field to be blocked by means of said shielding screen and a device for activating/deactivating said electromagnetic shielding screen, said detector-rectifier being configured, in the presence of the electromagnetic field with a power exceeding said minimum value, to activate said device for activating/deactivating the electromagnetic shielding screen by capturing the electromagnetic energy supplied by said electromagnetic fields with a power exceeding said minimum value.

IPC Classes  ?

• G01J 1/02 - Photometry, e.g. photographic exposure meter Details
• H05K 9/00 - Screening of apparatus or components against electric or magnetic fields

Abstract

A quasi-optical beamformer includes a plurality N> 1 of power feeds (PF), each of the i∈[1; N] power feeds (PF) being configured to emit a respective radio-frequency beam denoted Ri, a radio-frequency transmission line (LT) fed at a first end by the power feeds and comprising at a second end a plurality of network ports (PR) that are configured to collect radio-frequency radiation, the transmission line (LT) comprising a radio-frequency waveguide (GO) that comprises at least two metal plates (PM) that are stacked so as to guide the radio-frequency beams Ri, i∈[1; N] towards the network ports (PR), the transmission line (LT) extending along a central main axis denoted axis x, a first reflector (M1) having a first centre (C1) centred on the axis x and a first effective radius of curvature and being configured to reflect the guided radio-frequency beams Ri, i∈[1; N], a second reflector (M2) having a second effective radius of curvature and being configured to reflect the radio-frequency beams (RFi) reflected by the first reflector so as to direct them towards the network ports so as to form output radio-frequency beams (RSi), the first and second effective radii of curvature and an arrangement of the power feeds (PF) with respect to the first reflector being configured so that: each of the output radio-frequency beams (RSi) is a plane wave, and a transverse amplitude distribution Ai, on the network ports (PR), of each output radio-frequency beam (RSi), is substantially identical.

IPC Classes  ?

• H01Q 19/06 - Combinations of primary active antenna elements and units with secondary devices, e.g. with quasi-optical devices, for giving the antenna a desired directional characteristic using refracting or diffracting devices, e.g. lens
• H01Q 9/04 - Resonant antennas
• H01Q 23/00 - Antennas with active circuits or circuit elements integrated within them or attached to them
• H04B 7/06 - Diversity systemsMulti-antenna systems, i.e. transmission or reception using multiple antennas using two or more spaced independent antennas at the transmitting station

Abstract

FT{ΔTenppee(ω)) (5a, 5b, 5c) from said first Fourier transform

IPC Classes  ?

• G01R 29/08 - Measuring electromagnetic field characteristics
• G01N 25/72 - Investigating presence of flaws

Abstract

Quasi-optical beamformer (1) comprising.-a plurality N > 1 of powei feeds (PF), each of the i c [1;N] power feeds (PF) being configured to emit a respective radio-frequency beam denoted Ri,- a radio-frequency transmission line (LT) fed at a first end by the power feeds and comprising at a second end a plurality of network ports (PR) that are configured to collect radio-frequency radiation, the transmission line (LT) comprising a radio-frequency waveguide (GO) that comprises at least two metal plates (PM) that are stacked so as to guide the radio-frequency beams Ri, i c [1; IV] towards the network ports (PR), the lransmission line (LT) extending along a cenlral main axis denoted axis x,- a first reflector (M1) having a first centre (C1) centred on the axis x and a first effective radius of curvature and being configured to reflect the guided radio-frequency beams Roi c [1; N],- a second reflector (M2) having a second effective radius of curvature and being configured to reflect the radio-frequency beams (RF) reflected by the first reflector so as to direct them towards the network ports so as to form output radio-frequency beams (RSi), the first and second effective radii of curvature and an arrangement of the power feeds (PF) with respect to the first reflector being configured so that- each of the output radio-frequency beams (RS,) is a plane wave, and- a transverse amplitude distribution Ai, on the network ports (PR), of each output radio-frequency beam (RS), is substantially identical

IPC Classes  ?

• H01Q 15/14 - Reflecting surfacesEquivalent structures
• H01Q 19/17 - Combinations of primary active antenna elements and units with secondary devices, e.g. with quasi-optical devices, for giving the antenna a desired directional characteristic using reflecting surfaces wherein the surfaces are concave the primary radiating source comprising two or more radiating elements
• H05K 1/02 - Printed circuits Details

Abstract

The present invention relates to a compound of the following general formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, for use as drug for inhibiting ferroptosis. The present invention relates to a compound of the following general formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, for use as drug for inhibiting ferroptosis.

IPC Classes  ?

• C07D 471/04 - Ortho-condensed systems
• A61K 31/404 - Indoles, e.g. pindolol
• A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
• A61K 31/444 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
• A61K 31/4545 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• A61P 39/06 - Free radical scavengers or antioxidants
• C07D 209/12 - Radicals substituted by oxygen atoms

Abstract

The present invention provides SOCE inhibitors that are useful as therapeutic agents in a variety of applications. The present invention also relates to pharmaceutical compositions, products and kits comprising such SOCE inhibitors, and methods of using the SOCE inhibitors in the treatment of a variety of diseases.

IPC Classes  ?

• C07D 235/04 - BenzimidazolesHydrogenated benzimidazoles
• A61P 35/00 - Antineoplastic agents

Abstract

The invention relates to a device and method for measuring an electromagnetic dosimetric quantity received by an object illuminated by an electromagnetic (EM) field (23) emitted by an electromagnetic source (2), comprising: - a screen (3) comprising a top surface (31) faced to the electromagnetic source (2) and a bottom surface (32) opposite to the top surface (31 ), said screen (3) being adapted to absorb at least a portion of the EM field emitted by the electromagnetic source (2); - the screen comprising a plurality unit cells (33); - at least one thermal sensor (5) arranged relative to the bottom surface of the screen (3) and configured to measure a physical quantity relative to the heat distribution along a surface of the screen induced due to the absorption of the electromagnetic field in the screen medium; - a processing unit (6) linked to the at least one thermal sensor (5) and configured to calculate the electromagnetic dosimetric quantities from the measured heat distribution, the information relative to the EM field emitted by the EM source, and the predetermined EM and thermal properties of the screen.

IPC Classes  ?

• G01R 29/08 - Measuring electromagnetic field characteristics

Abstract

The invention concerns a system for controlling the temperature of a microfluidic chip comprising a Peltier module (10) having a cold face (10a) and a hot face (10b) and connected to a power generator (11), a thermal regulation device (12) having a thermal regulated face (12a) applied against one of the faces of the Peltier module, at least one temperature sensor (17) being applied on the other face of the Peltier module and being intended to be applied against one of the main faces of a microfluidic chip and control means (18) configured to control the power generator (11) of the Peltier module depending on a temperature of the face of the Peltier module provided with said at least one temperature sensor and at least one temperature setting information selected from a target temperature and a target temporal temperature profile to regulate a temperature of the face of the Peltier module to said temperature setting information.

IPC Classes  ?

• B01L 7/00 - Heating or cooling apparatusHeat insulating devices
• B01L 9/00 - Supporting devicesHolding devices

Abstract

Composite material comprising a ROMP-derived polyolefin embedded in a silicone matrix The present invention relates to a composite material comprising inclusions of a polyolefin obtainable by ring-opening metathesis polymerization of at least one cycloolefin, within a silicone matrix. It is also directed to a method for the preparation of this composite material and to the use of this composite material in the manufacture of various items.

IPC Classes  ?

• C08L 83/04 - Polysiloxanes
• C08G 61/08 - Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes only aliphatic carbon atoms prepared by ring-opening of carbocyclic compounds of carbocyclic compounds containing one or more carbon-to-carbon double bonds in the ring

Abstract

The invention relates to the use of a ternary alloy having the formula SixTiyNiz, wherein x, y and z are natural numbers, for use in electrolysis and photoelectrolysis, in particular photo-oxidation of water. One aspect of the invention relates to a method for the manufacture of an electrode, the method comprising a step of heating a carrier comprising a surface having a layer of silicon on which a layer of TiO2 is disposed, the layer of TiO2 being covered with a layer of NiO; the heating step being carried out at a temperature above 1,000° C., and preferably between 1,150° C. and 1,250° C. The invention also relates to an electrode comprising a carrier, said electrode having either: an outer surface on which particles of a ternary alloy having the formula SixTiyNiz are positioned, wherein x, y and z are natural numbers, and wherein the particles form protrusions; or an outer surface consisting of a layer of said alloy, the layer comprising protrusions.

IPC Classes  ?

• C25B 11/089 - Alloys
• C25B 11/059 - Silicon
• C25B 11/087 - Photocatalytic compound
• C23C 16/40 - Oxides
• C23C 16/455 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for introducing gases into the reaction chamber or for modifying gas flows in the reaction chamber

Abstract

The invention relates to a sealed porous support comprising at least one surface, said surface being covered with a first layer comprising natural latex and a second layer comprising a natural or synthetic wax, the first layer being in contact with the at least one surface of the porous support, and the second layer being in contact with the natural or synthetic wax. The invention also relates to a method for obtaining such a support.

IPC Classes  ?

• D06M 15/693 - Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials with macromolecular compoundsSuch treatment combined with mechanical treatment with natural or synthetic rubber, or derivatives thereof
• D06N 3/18 - Artificial leather, oilcloth, or like material obtained by covering fibrous webs with macromolecular material, e.g. resins, rubber or derivatives thereof with two layers of different macromolecular materials
• D21H 19/12 - Coatings without pigments applied as a solution using water as the only solvent, e.g. in the presence of acid or alkaline compounds
• D21H 19/18 - Coatings without pigments applied in a form other than the aqueous solution defined in group comprising waxes
• D21H 19/82 - Paper comprising more than one coating superposed
• C09D 107/00 - Coating composition based on natural rubber
• C09D 191/06 - Waxes
• D21H 27/10 - Packing paper
• C08L 7/02 - Latex
• B05D 1/18 - Processes for applying liquids or other fluent materials performed by dipping
• B05D 7/22 - Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials to internal surfaces, e.g. of tubes
• B05D 7/00 - Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials

Abstract

The invention relates to a composition comprising natural latex and a natural or synthetic wax, the proportion of the natural latex to the natural or synthetic wax being 40:60 to 60:40 by weight. The invention also relates to the use of such a composition for sealing a surface.

IPC Classes  ?

• C08L 7/02 - Latex
• B32B 29/06 - Layered products essentially comprising paper or cardboard specially treated, e.g. surfaced, parchmentised
• B65D 65/40 - Applications of laminates for particular packaging purposes
• C08L 91/06 - Waxes

Abstract

The invention relates to a method for preparing a polyester polymer material, which comprises preparing a reaction medium comprising a mixture of at least one monomer chosen from ω-hydroxylated fatty acids and ω-hydroxylated fatty acid esters of an alcohol comprising an aliphatic chain comprising from 1 to 18 carbon atoms, and at least one phenolic compound, the total content of phenolic compound(s) being within a range of values from 0.3 to 42 mg equivalent of gallic acid per gram of the mixture. The method then comprises heating this reaction medium in order to carry out the polymerisation of the monomer and the phenolic compound and the cross-linking of the polymer thus formed.

IPC Classes  ?

• C08G 63/06 - Polyesters derived from hydroxy carboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxy carboxylic acids

Abstract

The present invention belongs to the field of catalytic chemistry, and more specifically to catalysed oxidation of lignin. It also relates to synthesis of catalyst compounds. The present invention belongs to the field of catalytic chemistry, and more specifically to catalysed oxidation of lignin. It also relates to synthesis of catalyst compounds. The present invention relates to new acridinium-based photoredox catalyst compounds and their use thereof in a chemical reaction, preferably in depolymerisation of lignin models and ultimately lignin. The invention also relates to the method of synthesis of the new acridinium-based photoredox catalyst compounds according to the invention.

IPC Classes  ?

• B01J 31/02 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
• B01J 35/00 - Catalysts, in general, characterised by their form or physical properties
• B01J 37/34 - Irradiation by, or application of, electric, magnetic or wave energy, e.g. ultrasonic waves
• C07D 219/02 - Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with only hydrogen, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system

Abstract

Disclosed is an absorbent structure which is a honeycomb structure extending between two end faces and which includes tubular cells, each cell having walls delimiting the cell, the walls extending between the two end faces, the walls being formed from a dielectric material, at least one cell having at least one strip of electrically conductive coating arranged in at least one wall or over a surface of at least one wall, the honeycomb structure being characterized by parameters chosen so that the absorbent structure provides an attenuation of at least 10 dB for each incident wave in a frequency range having a frequency spread greater than or equal to 15 GHz.

IPC Classes  ?

• H01Q 17/00 - Devices for absorbing waves radiated from an antenna Combinations of such devices with active antenna elements or systems

Abstract

An active light-emitting layer composition including a thermally activated delayed fluorescence (TADF) molecule with TADF properties as a host material and a luminescent molecule with circularly polarized (CP) properties as a dopant. Also, a light-emitting device, such as an organic light-emitting diodes (OLED), including the active light-emitting layer made of this composition.

IPC Classes  ?

• H10K 85/60 - Organic compounds having low molecular weight
• C09K 11/02 - Use of particular materials as binders, particle coatings or suspension media therefor
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
• C07C 255/51 - Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings containing at least two cyano groups bound to the carbon skeleton
• C07D 213/06 - Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
• C07C 211/50 - Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring having at least two amino groups bound to the carbon skeleton with at least two amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton

Abstract

The method of the invention comprises the steps of: obtaining a flexible temporary substrate made from a material capable of dissolving in a bath of liquid while remaining at the surface thereof and of returning to its initial state when dried after having been taken out of the bath; obtaining a former having at least one convex surface region capable of mating with at least one concave surface region; forming an electronic function on one face of the temporary substrate; placing the temporary substrate bearing the electronic function in the bath to form a film on the surface of the bath; transferring the electronic function and the film bearing same onto the at least one convex surface of the former; removing the former from the bath and drying same in order to cause the temporary substrate to return to its initial state; moulding the part on the former; removing the former to obtain the desired part covered with the temporary substrate, which can either be kept or removed.

IPC Classes  ?

• B29C 45/14 - Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mouldApparatus therefor incorporating preformed parts or layers, e.g. injection moulding around inserts or for coating articles
• H05K 3/00 - Apparatus or processes for manufacturing printed circuits

Abstract

A device for controlling radiofrequency beams of a given polarization, the device includes a set of at least one cell, comprising a support frame and at least one interconnection internal to the frame. The frame is inscribed within a prism, having a given axis Z′ and faces connected to one another by edges oriented along the axis Z′. The frame comprises corner elements, each having a rim coincident with an edge and being arranged such that the frame has, on each face, a slot (440-n) extending along the axis Z′. The interconnection comprises inductive rods, each comprising two ends of which a first end is connected to a rim, the second ends being connected to one another at a connection point positioned in the centre of the frame in a plane orthogonal to the axis Z′. Each cell is configured to carry out polarization-invariant transmission and/or reflection of beams.

IPC Classes  ?

• H01Q 3/46 - Active lenses or reflecting arrays

Abstract

What is proposed is a device (300) for controlling radiofrequency beams of a given polarization, the device comprising a set of at least one cell (400), comprising a support frame (420) and at least one interconnection (460) internal to the frame. The frame is inscribed within a prism, having a given axis Z' and Ar faces connected to one another by Ar edges oriented along the axis Z'. The frame comprises Ar corner elements, each having a rim coincident with an edge and being arranged such that the frame has, on each face, a slot (440-n) extending along the axis Z'. The interconnection comprises Ar inductive rods (462-n), each comprising two ends of which a first end is connected to a rim, the second ends being connected to one another at a connection point positioned in the centre of the frame in a plane orthogonal to the axis Z'. Each cell is configured to carry out polarization-invariant transmission and/or reflection of beams.

IPC Classes  ?

• H01Q 15/10 - Refracting or diffracting devices, e.g. lens, prism comprising three-dimensional array of impedance discontinuities, e.g. holes in conductive surfaces or conductive discs forming artificial dielectric

Abstract

An optically transparent electromagnetic shielding assembly exhibiting a shielding efficiency that is increased when a conducting or polarizable fluid produces a low electrical impedance value between a periphery and a central region of a window. Such shielding assembly is useful in detection systems that are exposed to varying intensities of electromagnetic radiation, such as microwave radiation.

IPC Classes  ?

• H01L 31/0203 - Containers; Encapsulations
• H01L 23/552 - Protection against radiation, e.g. light
• H01L 25/16 - Assemblies consisting of a plurality of individual semiconductor or other solid-state devices the devices being of types provided for in two or more different subclasses of , , , , or , e.g. forming hybrid circuits

Abstract

CD95L is a transmembrane glycoprotein that acts through cell contact. After cleavage by metalloproteases, a soluble CD95L (cleaved CD95L or cl-CD95L) is released into the bloodstream. This soluble ligand contributes to aggravate chronic inflammatory disorders such as systemic lupus erythematosus (SLE) and may exert pro-oncogenic functions by promoting the survival of ovarian and breast cancers and chemotherapy resistance of lung cancers. The inventors hypothesized that monoclonal antibodies targeting the Metalloprotease-Cleavage Sites of CD95L (MCSCs) encompassing amino-acid residues 103 to 145 could prevent the access to metalloproteases and inhibit CD95L shedding. Therefore, they generated antibodies covering different epitopes within MCSC and two of them (i.e., 3C7 and 9F5), efficiently abrogated the cleavage of CD95L by MMP2 and MMP3. The results indicate that these MCSC- targeting mAbs can compete with MMPs and represent original and attractive therapeutic options to block the release of the inflammatory s-CD95L.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system
• A61P 35/00 - Antineoplastic agents

Abstract

A multilayer waveguide structure (2) for a radiofrequency antenna comprises: - a stack of substrates (4) separated by each other by interface layers (10), the substrates having a permittivity larger or equal to 1, and - metal vias (12) or metal trenches formed in at least some of the substrates. Each interface layer (10) comprises a first metal layer (16), a second metal layer (18), and an adhesive layer (14) between the first metal layer (16) and the second metal layer (18). At least one of said interface layer (10) comprises patterned structures (R12), for which the adhesive layer (14) is thinner while still preventing a direct electric contact between the first and second metal layers (16, 18), and each said patterned structure (R12) is located near or at the base or the top of a metal via (12) or metal trench.

IPC Classes  ?

• H01P 5/02 - Coupling devices of the waveguide type with invariable factor of coupling
• H05K 3/46 - Manufacturing multi-layer circuits
• H01Q 1/22 - SupportsMounting means by structural association with other equipment or articles
• H01P 5/12 - Coupling devices having more than two ports

Abstract

A multilayer waveguide structure (2) for a radiofrequency antenna comprises: - a stack of substrates (4) separated by each other by interface layers (10), the substrates having a permittivity larger or equal to 1, and - metal vias (12) or metal trenches formed in at least some of the substrates. Each interface layer (10) comprises a first metal layer (16), a second metal layer (18), and an adhesive layer (14) between the first metal layer (16) and the second metal layer (18). At least one of said interface layer (10) comprises patterned structures (R12), for which the adhesive layer (14) is thinner while still preventing a direct electric contact between the first and second metal layers (16, 18), and each said patterned structure (R12) is located near or at the base or the top of a metal via (12) or metal trench.

IPC Classes  ?

• H01P 5/02 - Coupling devices of the waveguide type with invariable factor of coupling
• H01P 5/12 - Coupling devices having more than two ports
• H01Q 1/22 - SupportsMounting means by structural association with other equipment or articles
• H05K 3/46 - Manufacturing multi-layer circuits

Abstract

The present invention relates to compounds simultaneously having thermally activated delayed fluorescence (TADF), circularly polarised luminescence (CPL) and aggregation-induced emission enhancement (AIEE) properties. The invention also relates to the use of such compounds as a photocatalyst or as a dopant, in particular in the emitting layers of light-emitting diodes (OLEDs), as well as light-emitting devices or light-emitting diodes (OLEDs) comprising such compounds.

IPC Classes  ?

• H10K 85/60 - Organic compounds having low molecular weight
• C07D 491/22 - Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups , , or in which the condensed system contains four or more hetero rings
• H10K 50/11 - OLEDs or polymer light-emitting diodes [PLED] characterised by the electroluminescent [EL] layers

Abstract

The present invention relates to a redox flow battery, comprising: - a first compartment comprising a negolyte, in the form of an aqueous composition, comprising at least one compound of formula (I) and/or a salt of the compound of formula (I), and/or a reduced form of the compound of formula (I), wherein X1, X2, X3, X4, X5, X6, X7and X8are independently selected from the group consisting of a hydrogen atom, a halogen, an ether group of formula -O-A, an OH group, a COOH group, an -A-COOH group, an -O-A-COOH group and a linear, cyclic or branched, saturated or unsaturated hydrocarbon group comprising from 1 to 10 carbon atoms, A representing a linear, cyclic or branched, saturated or unsaturated hydrocarbon group comprising from 1 to 10 carbon atoms, wherein at least one of X1, X2, X3, X4, X5, X6, X7and X866]4-66]3-, the negolyte additionally comprising at least one solubilising base, the solubilising base being characterised in that the pKa of the conjugate acid of the solubilising base is higher than 9.5 in water at 25°C and in that the volume of the cation of the solubilising base is between 14 and 650 cubic Angstroms.

IPC Classes  ?

• H01M 8/18 - Regenerative fuel cells, e.g. redox flow batteries or secondary fuel cells
• C08K 5/13 - PhenolsPhenolates

Abstract

The inventors have succeeded in developing urea, oxalamide, amide, thiourea, carbamate or ester compounds, in particular urea compounds, bearing two side groups, one of which carries a hydroxyphenyl or phenyl moiety, in particular a hydroxyphenyl moiety. These compounds have the advantage of inhibiting IRE1 RNase activity and sensitizing cancer cells, in particular GB cells, to chemotherapy. The present invention relates to urea, oxalamide, amide, thiourea, carbamate or ester compounds, in particular urea compounds containing a hydroxyphenyl or phenyl moiety, in particular a hydroxyphenyl moiety, including their pharmaceutically acceptable salts and solvates which are useful as sensitizers for chemotherapy of cancer cells, particularly in glioblastoma, and are useful as therapeutic compounds, particularly in the treatment of cancers that may be treated by alkylating agents, such as temozolomide.

IPC Classes  ?

• C07D 215/38 - Nitrogen atoms
• C07D 277/82 - Nitrogen atoms
• C07C 275/00 - Derivatives of urea, i.e. compounds containing any of the groups the nitrogen atoms not being part of nitro or nitroso groups
• A61K 31/47 - QuinolinesIsoquinolines
• A61K 31/428 - Thiazoles condensed with carbocyclic rings
• A61P 35/00 - Antineoplastic agents

Abstract

The invention relates to the use of a hydroperoxy alcohol-type compound, or a 1,2,4-trioxane compound thereof, as an antimicrobial agent, making it possible for it to be used in various applications and in particular as a preservative and/or to improve the antimicrobial properties of at least one preservative, to modulate the skin microbiota, in the treatment or prevention of diseases affecting the skin, the mucous membrane and/or skin appendages or even to cleanse, sanitise, disinfect and/or sterilise a surface other than the skin, skin appendages and mucous membranes, in particular a hard surface or a textile. It also relates to a composition comprising such a compound. In addition to its antimicrobial properties, the aforementioned compound has good safety and emollient properties, making it particularly suitable for cosmetic use.

IPC Classes  ?

• A61K 31/357 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
• A61K 31/327 - Peroxy compounds, e.g. hydroperoxides, peroxides, peroxy acids
• A61Q 5/00 - Preparations for care of the hair
• A61Q 7/00 - Preparations for affecting hair growth
• A61K 8/49 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
• A61Q 5/02 - Preparations for cleaning the hair
• A61Q 19/10 - Washing or bathing preparations
• A61Q 17/00 - Barrier preparationsPreparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

The present invention provides inhibitory peptides for use in the diagnostic and/or treatment of tauopathies, in particular Alzheimer's Disease and Pick's Disease. The inhibitory peptides comprise a hexapeptide sequence that specifically inhibits interactions of the PHF6 sequence within pathological Tau protein.

IPC Classes  ?

• A61K 38/08 - Peptides having 5 to 11 amino acids
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

2wnww being the weight- average molecular weight and Mn being the number-average molecular weight; a rheology long chain branching index grheo of at least 0.90, preferably at least 0.93, preferably at least 0.95; and preferably at least 0.30 % by weight of ethyl branching with regard to the total weight of the ethylene polymer measured by 13C NMR, with the proviso that said ethyl branching is not generated from 1 -butene incorporation as comonomer.

IPC Classes  ?

• C08F 210/16 - Copolymers of ethene with alpha-alkenes, e.g. EP rubbers
• C07F 17/00 - Metallocenes
• C08F 4/659 - Component covered by group containing a transition metal-carbon bond
• C07F 7/00 - Compounds containing elements of Groups 4 or 14 of the Periodic Table

Abstract

The present invention relates to a catalyst composition comprising: catalyst component A comprising the meso form of a bridged metallocene compound with two indenyl groups, each indenyl being independently substituted with one or more substituents, wherein at least one of the substituents is on position 3 and/or 5 of each indenyl, and wherein at least one of the substituents is an aryl or heteroaryl; wherein the meso/rac ratio of the meso form of the bridged metallocene compound of catalyst component A is 95:5 or greater, as determined using 1H NMR; preferably wherein the aryl or heteroaryl substituent is on the 3- position of each indenyl; catalyst component B comprising a bridged metallocene compound with two indenyl groups, each indenyl being independently substituted with one or more substituents, wherein at least one of the substituents is an unsubstituted or substituted aryl or heteroaryl; and wherein the unsubstituted or substituted aryl or heteroaryl is not on position 3 and/or 5 of the indenyl; and an optional activator; an optional support; and an optional co-catalyst. The present invention also relates to a polymerization process using said composition. The invention further relates to olefin polymers at least partially catalyzed by said catalyst composition and articles comprising said olefin polymers.

IPC Classes  ?

• C08F 210/16 - Copolymers of ethene with alpha-alkenes, e.g. EP rubbers
• C08F 4/659 - Component covered by group containing a transition metal-carbon bond

Abstract

The present invention provides inhibitory peptides for use in the diagnostic and/or treatment of tauopathies, in particular Alzheimer's Disease and Pick's Disease. The inhibitory peptides comprise a hexapeptide sequence that specifically inhibits interactions of the PHF6 sequence within pathological Tau protein.

IPC Classes  ?

• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• A61K 38/08 - Peptides having 5 to 11 amino acids
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

Chronic inflammatory diseases are becoming a leading cause of death throughout the world. Although such diseases appear to be clinically different, they share many similarities in terms of genetic background and pathophysiological pathways. There is an interest to develop drugs for inhibiting the CD95 -mediated non-apoptotic signaling pathway that contributes to inflammation. In particular, neutralizing anti-CD95L monoclonal antibodies are highly desirable. The inventors a neutralizing anti-CD95L monoclonal antibody (mAb), designated JQ3 (IgGl K). In particular, the neutralizing effect of JQ3 was confirmed since this home-made monoclonal antibody inhibited the CD95-mediated apoptotic signaling pathway induced in T- cell line Jurkat more efficiently than NOK-1 mAb. Interestingly, JQ3 blocked the CD95- mediated Ca2+ response in neutrophils exposed to sera from various inflammatory conditions (COVID19 patients and anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) patients). The present invention thus relates to neutralizing anti-CD95L monoclonal antibodies that revie from JQ3.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61P 37/00 - Drugs for immunological or allergic disorders
• A61P 35/00 - Antineoplastic agents
• A61P 37/02 - Immunomodulators

Abstract

An isolated monoclonal antibody against the interleukin 1-alpha or beta receptor antagonist, known as IL-1RA. The antibody inhibits the interaction of IL-1RA with the membrane-binding chain thereof, the interleukin-1 receptor. Also, nucleic acid molecule encoding for a light chain of the monoclonal antibody, and a nucleic acid molecule encoding for a heavy chain of the monoclonal antibody. Also, a method for treating an inflammatory, infectious or autoimmune disease, which includes administering the isolated monoclonal antibody or a nucleic acid coding for the isolated monoclonal antibody, and a method of or the diagnosis of an inflammatory, infectious or autoimmune diseases, which includes contacting a biological sample with the isolated monoclonal antibody.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• A61P 31/04 - Antibacterial agents

Abstract

The present invention relates to an iminium salt having the following formula (I) and also to a ruthenium complex having the following formula (II): (I) (II) as well as the use of said ruthenium complex as catalyst, in particular in olefin metathesis.

IPC Classes  ?

• C07D 209/58 - [b]- or [c]-condensed

Abstract

A technique and device for managing blocks of commands intended for a microscopy imaging device configured to acquire images of a sample. Each block of commands includes driving commands serving to drive a plurality of functional modules of the imaging device. Each command is defined by at least one acquisition parameter. The technique includes executing a first, predefined block of commands to acquire first images, and upon positive verification, by image analysis of a stop condition upon executing the first block, stopping the first block to execute a second predefined block of commands to acquire second images, the commands of the second block being defined by at least one second acquisition parameter, dynamically defined depending on the image analysis.

IPC Classes  ?

• G02B 21/36 - Microscopes arranged for photographic purposes or projection purposes
• G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts

Abstract

The present invention relates to an iminium salt having the following formula (I) and also to a ruthenium complex having the following formula (II): (I) (II) as well as the use of said ruthenium complex as catalyst, in particular in olefin metathesis.

IPC Classes  ?

• C07D 209/58 - [b]- or [c]-condensed
• B01J 31/00 - Catalysts comprising hydrides, coordination complexes or organic compounds
• C07F 15/00 - Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table

Abstract

The present invention thus provides a novel family of liposomal compositions (nanocarriers), hereinafter referred to as Tetra-Acidosomes, comprising natural tetrameric acid (TA) lipids and/or novel chemically functionalized tetrameric acid (CFTA) lipids, for drug delivery applications.

IPC Classes  ?

• A61K 47/50 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
• C07C 31/27 - Polyhydroxylic alcohols containing saturated rings
• C07C 55/26 - Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms containing rings
• C07C 69/60 - Maleic acid estersFumaric acid esters
• C07C 69/608 - Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a ring other than a six-membered aromatic ring in the acid moiety
• C07C 219/10 - Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to an acyclic carbon atom of a carbon skeleton containing rings
• C07D 249/04 - 1,2,3-TriazolesHydrogenated 1,2,3-triazoles

Abstract

The present invention thus provides a novel family of liposomal compositions (nanocarriers), hereinafter referred to as Tetra-Acidosomes, comprising natural tetrameric acid (TA) lipids and/or novel chemically functionalized tetrameric acid (CFTA) lipids, for drug delivery applications.

IPC Classes  ?

• C07C 31/27 - Polyhydroxylic alcohols containing saturated rings
• C07C 55/26 - Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms containing rings
• C07C 69/60 - Maleic acid estersFumaric acid esters
• C07D 249/04 - 1,2,3-TriazolesHydrogenated 1,2,3-triazoles
• A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
• A61K 47/50 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system
• C07C 219/10 - Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to an acyclic carbon atom of a carbon skeleton containing rings
• C07C 69/608 - Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a ring other than a six-membered aromatic ring in the acid moiety

Abstract

The invention relates to a self-adaptive shielding device for a lens or a window (1) of a piece of equipment provided with an electrically conductive enclosure (10) enclosing an optical or RF sensor (20) behind said lens or said window, said device comprising, on at least one face of said lens or said window, a shielding screen comprising a switchable RF shielding mesh (2) with a micrometric pitch at least partially surrounded by an edge of metal-insulator transition material (3) arranged between said mesh and an electrically conductive envelope (11) for shielding said equipment, comprising a susceptor element (5) arranged opposite or in contact with said metal-insulator transition material and suitable for transforming incident electromagnetic energy (RFH) into an amount of heat for activating said metal-insulator transition material (3, 3a, 31), said susceptor element being dimensioned to cause a transition to the conductive state of said metal-insulator transition material (3, 3a, 31, 31a) by means of said electromagnetic energy so as to electrically connect said mesh to said electrically conductive envelope when the incident electromagnetic energy exceeds a given threshold.

IPC Classes  ?

• G02B 26/00 - Optical devices or arrangements for the control of light using movable or deformable optical elements
• H05K 9/00 - Screening of apparatus or components against electric or magnetic fields
• G01J 5/06 - Arrangements for eliminating effects of disturbing radiationArrangements for compensating changes in sensitivity

Abstract

A device (1) for measuring a physical quantity related to an electromagnetic (EM) field emitted by an electromagnetic source (2), the device configured to simulate the EM characteristics of a reference object made of a lossy medium, e.g. a biological tissue, particularly a human tissue, comprising: - at least one dielectric layer (3) comprising an upper surface faced (31) to the electromagnetic source (2) and a bottom surface (32), said dielectric layer (3) being at least partly transparent to the EM field emitted by the electromagnetic source (2); - at least one electromagnetic field enhancing element (4) arranged relative to the at least one dielectric layer (3) and configured in a manner to enhance the intensity of the electromagnetic field transmitted through the at least one dielectric layer (3) in a predetermined zone (12); - at least one sensor (5) arranged beneath the at least one electromagnetic field enhancing element (4) and configured to measure said physical quantity related to the electromagnetic field transmitted through the at least one dielectric layer (3) and the at least one electromagnetic field enhancing element (4).

IPC Classes  ?

• G01R 29/08 - Measuring electromagnetic field characteristics
• H04B 17/00 - MonitoringTesting
• G09B 23/30 - Anatomical models
• H04M 1/24 - Arrangements for testing

Abstract

A device (1) for measuring a physical quantity related to an electromagnetic (EM) field emitted by an electromagnetic source (2), the device configured to simulate at least one EM scattering characteristic of a reference object made of an EM lossy medium, in particular a biological tissue, comprising: - at least one dielectric layer (3) comprising a top surface (31) oriented to the electromagnetic source (2) and a bottom surface (32), said layer (3) being at least partly transparent to the EM field emitted by the electromagnetic source (2); - at least one aperture focusing element (4) attached to or at least partly embedded in the bottom surface (32) of the dielectric layer (3), said at least one aperture focusing element (4) configured to focus the EM field incident on the at least one aperture element (4) into a focal zone (9); - at least one sensor (5) arranged beneath the at least one aperture focusing element (4) and configured to measure the physical quantity related to the electromagnetic field transmitted through the at least one dielectric layer (3) and the aperture focusing element (4), said at least one sensor (5) being positioned in the focal zone (9).

IPC Classes  ?

• G01R 29/08 - Measuring electromagnetic field characteristics
• G09B 23/30 - Anatomical models
• H04B 17/00 - MonitoringTesting
• H04M 1/24 - Arrangements for testing

Abstract

The present invention relates to the treatment of diseases induced by Enterobacteriae. The inventors evaluated, in a multicellular in vitro model associating cells representing human enterocytes (Caco-2 cells), goblet mucus secreting cells (HT29-MTX) and M cells, whether Bacteroides fragilis, a non-enterotoxigenic strain, could be useful to limit the severity of the Salmonella Heidelberg infection, with an hypermutator phenotype, by analyzing their impact on growth and mucosal translocation. Thus, the present invention relates to a Bacteroides fragilis strain for use in the treatment of diseases induced by Enterobacteriae in a subject in need thereof.

IPC Classes  ?

• A61K 35/741 - Probiotics
• A61P 31/04 - Antibacterial agents

Abstract

111.

IPC Classes  ?

• G01R 29/08 - Measuring electromagnetic field characteristics
• G09B 23/30 - Anatomical models
• H04B 17/00 - MonitoringTesting
• H04M 1/24 - Arrangements for testing

Abstract

This method for predicting frailty of a subject, using a wearable device, comprising an accelerometer, worn in unsupervised conditions, comprising: •computing (58) a plurality of global features representative of the acceleration signals captured during a predetermined observation period, •extracting (60) segments of acceleration signals within at least one period of walking of the subject within the observation period and computing (62) a plurality of local features representative of the subject's gait, •applying a first frailty assessment module (64) on the plurality of global features to obtain a first output representative of the frailty of the subject, •applying a second frailty assessment module (66) on the plurality of local features to obtain a second output representative of the frailty of the subject, •combining (68) the first and second outputs (64, 66) to predict a status of frailty of the subject amongst the classes {robust, pre-frail, frail} for the predetermined observation period.

IPC Classes  ?

• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

A sensor for detecting a volatile compound or gas. The sensor includes a transducer having: a planar resonator including a plurality of metal tracks, on a printed circuit, of the coplanar type; and a sensitive layer deposited on a predetermined portion of the resonator. The sensitive layer is configured so that the presence of a volatile compound or of a gas to be detected implies a modification of the permittivity of the sensitive layer resulting in a modification of the features of the sensor during its electrical power supply.

IPC Classes  ?

• G01N 27/02 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

The invention relates to a device (1) for determining polarimetric information, comprising: - an excitation source (2) suitable for exciting a measurement point (31) of a sample (3) in order to cause a luminescent beam to be emitted by the measurement point; - an optical collection system (5) configured to collect the luminescence signal; - a rotary analyser (7) configured to modulate the intensity of the luminescent beam on the basis of the polarisation angle of the rotary analyser; - a detector (9) able to acquire a signal of the intensity of the modulated luminescent beam; - a synchronisation unit (11) configured to synchronise the acquisition of the signal by the detector (9) and the rotation of the rotary analyser (7) such that the signal acquisition frequency is a multiple of the rotational frequency of the analyser (7); - a data processing unit (20) configured to determine at least one piece of polarimetric information contained in the signal of the luminescent beam.

IPC Classes  ?

• G01N 21/21 - Polarisation-affecting properties
• G01N 21/64 - FluorescencePhosphorescence

Abstract

The invention relates to a supramolecular nanotube comprising at least one single-chain magnet including a coordination polymer, said coordination polymer comprising at least one linear macromolecular chain comprising repeating units containing at least one metal, said metal being coordinated by at least one ligand comprising at least one linear carbon chain, said linear carbon chain comprising more than 5 carbons, preferably the linear carbon chain comprises 6 to 30 carbons.

IPC Classes  ?

• C08L 101/12 - Compositions of unspecified macromolecular compounds characterised by physical features, e.g. anisotropy, viscosity or electrical conductivity
• B82Y 10/00 - Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic

Abstract

An antenna (100) comprising at least a first resonant cavity (110) and a second resonant cavity (120), each resonant cavity (110, 120) being closed off by a base (112, 122) at one end and comprising a radiating element (111, 121) superimposed on the base of the resonant cavity, the radiating element (111) of the first cavity (110) being able to emit a signal in a first frequency band and the radiating element (121) of the second cavity (120) being able to emit a signal in a second frequency band separate from the first frequency band, characterized in that a first distance between the base (112) and the radiating element (111) of the first cavity (110) is different from a second distance between the base (122) and the radiating element (121) of the second cavity (120).

IPC Classes  ?

• H01Q 1/28 - Adaptation for use in or on aircraft, missiles, satellites, or balloons
• H01Q 5/48 - Combinations of two or more dipole type antennas
• H01Q 19/10 - Combinations of primary active antenna elements and units with secondary devices, e.g. with quasi-optical devices, for giving the antenna a desired directional characteristic using reflecting surfaces
• H01Q 21/26 - Turnstile or like antennas comprising arrangements of three or more elongated elements disposed radially and symmetrically in a horizontal plane about a common centre

Abstract

The present invention relates to a process for the preparation of an optically pure (+) or (-) enantiomer of an iminium salt having the formula (I), aid process comprising the following steps: • a) a reduction step of an iminium salt having the formula (II), said salt being in the form of a racemic mixture, in order to obtain a compound having the formula (III) in the form of a racemic mixture, • b) a step of chiral HPLC separation of the compound of formula (III) in the form of a racemic mixture, for obtaining an optically pure (+) or (-) enantiomer compound having the formula (IV), and • c) an oxidation step of the compound of formula (IV) for obtaining the compound of formula (I).

IPC Classes  ?

• C07D 207/20 - Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
• C07D 471/08 - Bridged systems
• B01J 31/22 - Organic complexes
• C07C 6/02 - Metathesis reactions at an unsaturated carbon-to-carbon bond

Abstract

The present invention relates to a process for preparing hydroperoxy alcohols using hydrogen peroxide as an oxidant in a solvent selected from water-soluble carboxylic acids, in the presence of a metallic mixed oxide heterogeneous catalyst. It also pertains to the use of this catalyst in the synthesis of hydroperoxy alcohols.

IPC Classes  ?

• C07C 409/02 - Peroxy compounds the —O—O— group being bound between a carbon atom, not further substituted by oxygen atoms, and hydrogen, i.e. hydroperoxides
• B01J 23/00 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group

Abstract

Method for operando characterization of the chemical composition of a battery cell (12), comprising the following steps: - inserting an optical fiber (14) made of chalcogenide glass through the battery cell (12), - cycling the battery (12), - while cycling the battery (12), generating an optical signal and transmitting it through the optical fiber (14), - detecting, using an infrared spectrometer (20), the transmitted optical signal at an output extremity (14O) of the optical fiber (14), - recording the detected optical signal over time, - locating, using fiber evanescent wave spectroscopy, signature wavelengths for which the optical signal intensity is above a predetermined threshold within the spectrum, - associating said located signature wavelengths to at least one predetermined chemical species.

IPC Classes  ?

• G01N 21/27 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
• G01N 21/3577 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing liquids, e.g. polluted water
• G01N 21/552 - Attenuated total reflection
• G01N 21/75 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated

Abstract

The invention relates to a vial (100) for the cryopreservation of multiple biological samples. This vial (100) comprises: a container (110), made in one piece, defining an inner volume (112) and an opening provided with a thread (132); and a threaded cap (150), which cooperates with the thread (132) of the opening so as to selectively close the inner volume (112), in a sealed configuration of the vial (100), or allow the access to the inner volume (112), in an unsealed configuration of the vial (100). According to the invention, the container (110) includes at least one inner partition (124), configured to divide the inner volume (112) in at least two separated chambers (126), each chamber (126) being accessible from the opening (114). Each chamber is configured to receive one biological sample. The vial according to the invention is easy to handle and space-saving. Also disclosed is a mounting base comprising at least one recessed reception volume that is configured to receive such a vial.

IPC Classes  ?

• A01N 1/02 - Preservation of living parts
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• B01L 9/06 - Test-tube standsTest-tube holders
• B01L 7/00 - Heating or cooling apparatusHeat insulating devices

Abstract

A method of obtaining 3D cell structures including differentiated human hepatic cells. The method includes: a first step of culturing stem cell-derived or immortalized human hepatic progenitors in a non-adherent culture vessel, preferably a low or ultra-low attachment culture vessel; a second step of transferring the stem cell-derived or immortalized human hepatic progenitors to a culture medium including methacrylated gelatin (GelMa), thereby embedding the stem cell-derived or immortalized human hepatic progenitors in a GelMa matrix; and a third step of covering the GelMa matrix with culture medium and culturing the stem cell-derived or immortalized human hepatic progenitors embedded in the GelMa matrix, thereby obtaining 3D cell structures including differentiated human hepatic cells. Also, methods for engineering an artificial liver model or an artificial liver organ, and for assessing in vitro the metabolism, toxicity and/or therapeutic effects of a compound.

IPC Classes  ?

• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

A device for locating target points on a magnetic resonance image of the brain of a subject includes a trained neural network configured to receive as input a 3D MR image of the brain of a subject, and to output the location, on the image, of at least one determined brain target point. The neural network includes a plurality of processing stages. Each processing stage processes an image at a respective resolution, and the processing stage of lowest resolution outputs an estimate of the location of each target point. Each other processing stage is configured to receive, from a lower resolution processing stage, an estimate of the locations of the target points, crop the input image to a smaller region surrounding each estimated target point, determine an updated estimate of the location of each target point, and provide the updated estimation to the processing stage of the next higher resolution.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation

Abstract

The present invention relates to a catalyst of Formula (I) wherein R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, L1, M1, Q1, and Q2 have the meaning defined in the description and claims. The present invention also relates to a catalyst composition comprising at least one catalyst according to the invention, an optional activator; an optional support; and an optional co-catalyst. The present invention also relates to the use of a catalyst or catalyst composition according to the invention for the preparation of an olefin polymer. The present invention also relates to an olefin polymerization process, the process comprising: contacting a catalyst or a catalyst composition according to the invention, with an olefin monomer, optionally hydrogen, and optionally one or more olefin comonomers; polymerizing the monomer, and the optionally one or more olefin comonomers, in the presence of the at least one catalyst composition, and optional hydrogen, thereby obtaining an olefin polymer. The present invention also relates to olefin polymers and articles comprising said olefin polymer.

IPC Classes  ?

• C08F 4/00 - Polymerisation catalysts
• C08F 110/00 - Homopolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond
• C07F 17/00 - Metallocenes

Abstract

PIM2 kinase deregulation has been reported in several cancers. In particular, PIM2 is considered in multiple myeloma as part of the oncogenic process and several PIM kinase inhibitors have been developed showing encouraging results in preclinical studies and clinical trials. Now the inventors have developed an antisense RNA strategy based on a splice-switching oligonucleotide (SSO) so as to induce efficient knockdown of PIM2 expression. This SSO-mediated knockdown is a powerful approach to for cancer treatments. Accordingly, the present invention relates to the use of splice switching oligonucleotides for exon skipping-mediated knockdown of PIM2.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

The invention relates to an electromagnetic wave damping system including a dielectric support (7) having a first face and a second face, and at least one frequency damping element (6), characterised in that the at least one damping element comprises a first pattern (8) arranged on the first face of the support, and a second pattern (9) arranged on the second face of the support.

IPC Classes  ?

• H01Q 17/00 - Devices for absorbing waves radiated from an antenna Combinations of such devices with active antenna elements or systems
• H01Q 15/00 - Devices for reflection, refraction, diffraction or polarisation of waves radiated from an antenna, e.g. quasi-optical devices
• H01Q 1/40 - Radiating elements coated with, or embedded in, protective material

Abstract

The present invention relates to a method for selecting at least one micropeptide able to alter the microbiome influenced by roots of a plant based on identifying miRNAs secreted by said plant in a sample of the roots and/or rhizosphere. The present invention also relates to a micropeptide able to alter the microbiome influenced by roots of a plant and its use as a plant microbiome modulating agent, for example for inducing a phenotype of interest, such as a pathogen resistance and/or a water resistance.

IPC Classes  ?

• A01H 1/00 - Processes for modifying genotypes
• A01H 3/04 - Processes for modifying phenotypes by treatment with chemicals
• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
• A01N 33/00 - Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds

Abstract

The present invention relates to a method for oxidative cleavage of a substrate consisting of at least one functionalised or non-functionalised linear olefin, in particular a mono- or polyunsaturated aliphatic carboxylic acid, or one of the esters thereof, or at least one non-functionalised cyclic olefin, using hydrogen peroxide, in the presence of a metal catalyst which consists of at least one onium halooxodiperoxometallate. It also relates to a novel catalyst consisting of a specific onium halooxodiperoxometallate which can be used, in particular, in said method.

IPC Classes  ?

• C07C 51/25 - Preparation of carboxylic acids or their salts, halides, or anhydrides by oxidation with molecular oxygen of unsaturated compounds containing no six-membered aromatic ring
• B01J 31/02 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides

Abstract

The present invention relates to a method of manufacturing a composite material comprising at least one ply (400) integrating at least one electronic element (200, 201, 202) situated at the surface of said ply (400), and to said materials obtained thereof and devices comprising such materials, said method comprising the following steps: a) preparing or providing a first substrate T (100) comprising at least one layer; b) applying at least one electronic element (200, 201, 202) onto a face of the said first substrate T (100); c) at least partially impregnating the so-obtained product within an impregnation material to form a matrix (302) incorporating the at least one electronic element (200, 201, 202) and the first substrate T (100); d) preparing or providing an impregnable second substrate P (301), said second substrate P (301) being placed on top of the impregnated at least one electronic element (200, 201, 202) so that the at least one electronic element is interposed between the first substrate T (100) and the second substrate P (300); e) removing the first substrate T (100) from the impregnated product obtained in step d); f) recovering the composite material.

IPC Classes  ?

• B29C 70/86 - Incorporating in coherent impregnated reinforcing layers

Abstract

A system for controlling the activation/deactivation of an electromagnetic shielding screen (11a, 11b, 11c, 11d) of a porthole or a protective window of an optoelectronic equipment, which includes, a radiofrequency electromagnetic sensor (1), with a bandwidth adapted to a cut-off band of said shielding screen corresponding to a range of electromagnetic fields to be blocked, connected to a detector-rectifier (2) with a sensitivity higher than a minimum value of the power of an electromagnetic field to be blocked by means of said shielding screen and a device (13, 14, 15, 16) for activating/deactivating said electromagnetic shielding screen, said detector-rectifier being configured, in the presence of the electromagnetic field with a power exceeding said minimum value, to activate said device (13, 14, 15, 16) for activating/deactivating the electromagnetic shielding screen by capturing the electromagnetic energy supplied by said electromagnetic fields with a power exceeding said minimum value. Figure of the abstract: Figure 1

IPC Classes  ?

• G01J 5/06 - Arrangements for eliminating effects of disturbing radiationArrangements for compensating changes in sensitivity

Abstract

Control system for activating/deactivating an electromagnetic shielding screen (11a, 11b, 11c, 11d) of a porthole or of a window for protecting optoelectronic equipment, which comprises, a radiofrequency electromagnetic sensor (1), of passband matched to a blocking band of said shielding screen corresponding to a range of electromagnetic fields to be blocked, which is connected to a detector-rectifier (2) of sensitivity higher than a minimum value of the power of an electromagnetic field to be blocked by means of said shielding screen and a device (13, 14, 15, 16) for activating/deactivating said electromagnetic shielding screen, said detector-rectifier being configured to, in the presence of electromagnetic fields of power exceeding said minimum value, activate said device (13, 14, 15, 16) for activating/deactivating the electromagnetic shielding screen by capturing electromagnetic energy delivered by said electromagnetic fields of power exceeding said minimum value.

IPC Classes  ?

• G01J 5/06 - Arrangements for eliminating effects of disturbing radiationArrangements for compensating changes in sensitivity

Abstract

The present invention relates to a compound of the following general formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, for use as drug for inhibiting ferroptosis.

IPC Classes  ?

• A61K 31/404 - Indoles, e.g. pindolol
• A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
• A61K 31/444 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
• A61K 31/4545 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• C07D 209/12 - Radicals substituted by oxygen atoms
• C07D 471/04 - Ortho-condensed systems
• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues

Abstract

The present invention relates to a compound of the following general formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, for use as drug for inhibiting ferroptosis.

IPC Classes  ?

• A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
• A61P 9/00 - Drugs for disorders of the cardiovascular system
• A61P 25/00 - Drugs for disorders of the nervous system
• C07D 471/04 - Ortho-condensed systems